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JOURNAL ARTICLE
Brisa Rodope Alarcón-Sánchez, Osiris Germán Idelfonso-García, Dafne Guerrero-Escalera, Carolina Piña-Vázquez, Guillermo de Anda-Jáuregui, José Luis Pérez-Hernández, Mireya de la Garza, Francisco García-Sierra, Yesennia Sánchez-Pérez, Rafael Baltiérrez-Hoyos, Verónica Rocío Vásquez-Garzón, Pablo Muriel, Julio Isael Pérez-Carreón, Saúl Villa-Treviño, Jaime Arellanes-Robledo
The worst-case scenario related to alcoholic liver disease (ALD) arises after a long period of exposure to the harmful effect of alcohol consumption along with other hepatotoxics. ALD encompasses a broad spectrum of liver-associated disorders, such as steatosis, steatohepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Based on the chronic administration of different hepatotoxics, including ethanol, sucrose, lipopolysaccharide, and low doses of diethylnitrosamine over a short period, here we aimed to develop a multiple hepatotoxic (MHT)-ALD model in the mouse that recapitulates the human ALD-associated disorders...
April 13, 2024: Biochemical Pharmacology
#2
JOURNAL ARTICLE
Sittarthan Viswanathan, Thennavan Arumugam, Kavimani Subramanian, Rengaraj Sivaraj, Vimalavathini Ramesh, A Hannah Rachel Vasanthi
Flavonoids are promising therapeutics for the treatment of Alzheimer's disease (AD). Therefore, it is of interest to study the anti-AD potential of 35 flavonoids towards the inhibition of AchE and BACE-1. Hence, the physicochemical, pharmacokinetic parameters, toxicity risk and drug-likeliness of the selected 35 flavonoids were computed. Further, the molecular docking analysis of flavonoids with AChE and BACE-1 were completed. A binding energy of -10.42 kcal/mol Epicatechin gallate, -10.16 kcal/mol sterubin and -10...
2024: Bioinformation
#3
JOURNAL ARTICLE
Sabina Akter, Bader Y Alhatlani, Emad M Abdallah, Supriyo Saha, Jannatul Ferdous, Md Emdad Hossain, Ferdausi Ali, Sarkar M A Kawsar
The pursuit of innovative combinations for the development of novel antimicrobial and antiviral medications has garnered worldwide interest among scientists in recent times. Monosaccharides and their glycosides, such as methyl α-d-mannopyranoside derivatives, play a significant role in the potential treatment of viral respiratory pathologies. This study was undertaken to investigate and assess the synthesis and spectral characterization of methyl α-d-mannopyranoside derivatives 2 - 6 , incorporating various aliphatic and aromatic groups...
December 7, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
#4
JOURNAL ARTICLE
Juan A Hernández-Aceves, Jacquelynne Cervantes-Torres, Diana Torres-García, Francisco J Zuñiga-Flores, Osiris J Patiño-Chávez, Jorge A Peña Agudelo, José Eduardo Aguayo-Flores, Yonathan Garfias, Laura Montero-León, Laura Romero-Romero, Armando Pérez-Torres, Gladis Fragoso, Edda Sciutto
Breast cancer is the leading malignancy in women worldwide, both in terms of incidence and mortality. Triple-negative breast cancer (TNBC) is the type with the worst clinical outcomes and with fewer therapeutic options than other types of breast cancer. GK-1 is a peptide that in the experimental model of the metastatic 4T1 breast cancer has demonstrated anti-tumor and anti-metastatic properties. Herein, GK-1 (5 mg/kg, i.v.) weekly administrated not only decreases tumor growth and the number of lung macro-metastases but also lung and lymph nodes micro-metastases...
September 22, 2023: Cancer Immunology, Immunotherapy: CII
#5
JOURNAL ARTICLE
Heba Ali Hassan, Sayed F Abdelwahab, Ahmad Al-Khdhairawi, Mrtatha K Al Zrkani, Hafiz Muzzammel Rehman, Islam M Abdel-Rahman, Azza A K El-Sheikh, Mahmoud M Abdelhamid
The recent outbreak of the Ebola virus (EBOV) has marked it as one of the most severe health threats globally. Among various anti-EBOV inhibitors studied, galidesivir (BCX4430) has shown remarkable efficacy. This study aims to identify novel potential anti-EBOV drugs among galidesivir analogs, focusing on the Zaire ebolavirus (Z-EBOV), which exhibits a mortality rate of 90%. We subjected 200 candidate compounds to molecular docking calculations, followed by an evaluation of the bioactivity of the top 25 compounds using the OSIRIS Property Explorer...
July 21, 2023: Journal of Biomolecular Structure & Dynamics
#6
JOURNAL ARTICLE
Osiris González Romero
This research aims to conceptualize cognitive liberty and the psychedelic humanities by examining their constitutive elements. The importance of this study lies in the fact that it is widespread to talk about psychedelic science nowadays, but there is a significant gap in the research. For instance, the role and importance of the humanities need to be acknowledged. Regarding cognitive liberty, this research considers that people have the right to use or refrain from using emerging neurotechnologies and psychedelics...
2023: Frontiers in Psychology
#7
JOURNAL ARTICLE
Mohammad I Hosen, Yousef E Mukhrish, Ahmed Hussain Jawhari, Ismail Celik, Meryem Erol, Emad M Abdallah, Mohammed Al-Ghorbani, Mohammed Baashen, Faisal A Almalki, Hamid Laaroussi, Taibi Ben Hadda, Sarkar M A Kawsar
Due to the uneven distribution of glycosidase enzyme expression across bacteria and fungi, glycoside derivatives of antimicrobial compounds provide prospective and promising antimicrobial materials. Therefore, herein, we report the synthesis and characterization of six novel methyl 4,6- O -benzylidene-α-d-glucopyranoside (MBG) derivatives ( 2 - 7 ). The structures were ascertained using spectroscopic techniques and elemental analyses. Antimicrobial tests (zone of inhibition, MIC and MBC) were carried out to determine their ability to inhibit the growth of different Gram-positive, Gram-negative bacteria and fungi...
March 13, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
#8
JOURNAL ARTICLE
Zeenat Mirza, Sajjad Karim
Identifying cancer biomarkers is imperative, as upregulated genes offer a better microenvironment for the tumor; hence, targeted inhibition is preferred. The theme of our study is to predict molecular interactions between cancer biomarker proteins and selected natural compounds. We identified an overexpressed potential molecular target (AKT1) and computationally evaluated its inhibition by four dietary ligands (isoliquiritigenin, shogaol, tehranolide, and theophylline). The three-dimensional structures of protein and phytochemicals were retrieved from the RCSB PDB database (4EKL) and NCBI's PubChem, respectively...
March 13, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
#9
JOURNAL ARTICLE
Anthony Gutiérrez-Martínez, Luis López-Zabala, Melanie Moronta-Franco, Osiris Fernández-Betances, Raúl López-Fañas, Danny Arias-Díaz, Fiodor Tejada-Toribio, Fausto Warden, Persio López, Franklyn Colón-Arias
OBJECTIVE: To identify the procoagulant phenomenon in SARS-CoV-2 patients and propose sustainable therapeutic guidance for low-income countries. METHODS: A systematic review was conducted. It identified 5 observational studies from a scrutiny from 78 results. 712 patients were examined and the results were grouped according to mortality and severity. The comparison of the groups was interpreted using descriptive statistics. RESULTS: D-dimer values were significantly associated with greater severity and mortality...
February 6, 2023: Revista de Salud Pública
#10
JOURNAL ARTICLE
David O Oladejo, Gbolahan O Duselu, Titilope M Dokunmu, Itunuoluwa Isewon, Jelili Oyelade, Esther Okafor, Emeka Ej Iweala, Ezekiel Adebiyi
Plasmodium falciparum Apicomplexan Apetala 2 Invasion ( Pf AP2-I) transcription factor (TF) is a protein that regulates the expression of a subset of gene families involved in P. falciparum red blood cell (RBC) invasion. Inhibiting Pf AP2-I TF with small molecules represents a potential new antimalarial therapeutic target to combat drug resistance, which this study aims to achieve. The 3D model structure of Pf AP2-I was predicted ab initio using ROBETTA prediction tool and was validated using Save server 6...
2023: Bioinformatics and Biology Insights
#11
JOURNAL ARTICLE
Gleison Gonçalves Ferreira, Ana Carolina Sousa Quaresma, Dayse Lúcia do Nascimento Brandão, Andrey Moacir do Rosario Marinho, José Edson de Sousa Siqueira, Kamila Leal Correa, José Otávio Carréra Silva-Júnior, Sandro Percario, Maria Fâni Dolabela
Cancer is a multifactorial organic dysfunction for which great efforts are being devoted in searching for new treatments and therapeutic adjuvants. Annona muricata is a fruit that has promising activity against several types of cancer, as it contains acetogenins, the metabolite group associated with this action. Thus, the objective of this study was to evaluate, in experimental models, the toxic behavior of an extract and fraction rich in acetogenins from A. muricata seeds and study the acetogenin, Annonacin, in silico...
December 27, 2022: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
#12
JOURNAL ARTICLE
Senem Akkoc, Halis Karatas, Muhammed Tilahun Muhammed, Zülbiye Kökbudak, Ahmet Ceylan, Faisal Almalki, Hamid Laaroussi, Taibi Ben Hadda
Since Schiff base derivatives have a wide range of biological activities, novel Schiff base derivatives were designed and synthesized in satisfactory yields. 1 H NMR, 13 C NMR, IR, mass and elemental analysis were used to provide a complete structural characterization of the new synthesized Schiff bases ( 3-6 ). The antiproliferative activity properties of compounds were tested against two human cancer cell lines including breast (MDA-MB-231) and colon (DLD-1). The compounds overall did not show high cytotoxic activity against both cancer cell lines compared to the positive control drug cisplatin...
August 13, 2022: Journal of Biomolecular Structure & Dynamics
#13
JOURNAL ARTICLE
Megha P Nambiar, N Ashwanikumar, Anakuthil Anoop, A R Biju
Epilepsy is a severe neurological disorder that occurs when the communication between the neurons is disturbed. Gamma-amino butyric acid-associated protein (GABARAP) plays a key role in balancing Gamma-aminobutyric acid-A (GABA(A)) receptor functions of inhibiting the neurotransmission and controlling the seizure. In this study, we introduce the derivatives of the selected anti-epileptic drugs, namely Felbamate and Clobazam, by substituting different hydrophilic and hydrophobic groups at the specified positions...
August 9, 2022: Journal of Biomolecular Structure & Dynamics
#14
JOURNAL ARTICLE
David Oladejo, Gbolahan Oduselu, Titilope Dokunmu, Itunuoluwa Isewon, Esther Okafor, Emeka E J Iweala, Ezekiel F Adebiyi
Recent treatment failures observed for Artemisinin-based combination therapy (ACT) have raised concerns about the efficacy of the front-line drug to treat malaria and the need to develop a new antimalarial drug regimen. Plasmodium falciparum Apicomplexan Apetala 2 Invasion (PfAP2-I) transcription factor (TF) is a protein that regulates the expression of a subset of gene families involved in Plasmodium falciparum red blood cell (RBC) invasion. Inhibiting PfAP2-I TF with small molecules represents a potential new antimalarial therapeutic target to combat drug resistance, which is the aim of this study...
May 2022: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
#15
JOURNAL ARTICLE
Armando Zepeda-Bastida, Juan Ocampo-López, Brisa Rodope Alarcón-Sánchez, Osiris Germán Idelfonso-García, Sandra Rosas-Madrigal, Diana Ivette Aparicio-Bautista, Julio Isael Pérez-Carreón, Saúl Villa-Treviño, Jaime Arellanes-Robledo
Hepatocellular carcinoma (HCC), which is the most frequent primary liver malignancy, is ranked as the sixth most common cancer and the third leading cause of cancer-related deaths worldwide, with its incidence expected to continue rising. One of the reasons is that most patients are diagnosed at an advanced stage when therapeutic options are ineffective. The development of HCC is attributed to a chronic exposition to either one or a combination of low amounts of different hepatotoxins, such as in hepatitis virus infection, alcohol consumption, aflatoxin from contaminated foods, metabolic factors, and exposure to chemical carcinogens from tobacco smoke (Forner et al...
December 15, 2021: Journal of Zhejiang University. Science. B
#16
JOURNAL ARTICLE
Angie Herrera-R, Wilson Castrillón, Manuel Pastrana, Andres F Yepes, Wilson Cardona-G
We synthesized twelve hybrids, S -allyl Cysteine methyl, ethyl and propyl ester-based non-steroidal anti-inflammatory drugs and their structures were elucidated by spectroscopic analysis. The chemopreventive potential of all compounds was evaluated against SW480 human colon adenocarcinoma cells and the non-malignant CHO-K1 cell line. Among the tested compounds, hybrids 10b-c , 11b and 12b displayed the best anticancer activity with IC50 values between 0.131-0.183 mM and selectivity indices higher than 1 after 48 h of treatment...
2021: Iranian Journal of Pharmaceutical Research: IJPR
#17
JOURNAL ARTICLE
Emilie Cloatre, Nayeli Urquiza-Haas, Michael Ashworth
The practice of healing by anyone other than qualified doctors or pharmacists has been allegedly illegal in France since the nineteenth century. In this judicial order, the state delegated the power to oversee the boundaries of medicine to doctors and pharmacists, allowing them, with support from criminal courts, to determine which therapeutic techniques should remain their exclusive right. In practice, this apparently neat legal system was never clear-cut; therapists without medical qualifications continued to infringe upon spaces that doctors and pharmacists saw as their preserve, often carving out zones of juridical tolerance...
2021: Osiris
#18
JOURNAL ARTICLE
Ivan Delgado-Enciso, Juan Paz-Garcia, Carlos E Barajas-Saucedo, Karen A Mokay-Ramírez, Carmen Meza-Robles, Rodrigo Lopez-Flores, Marina Delgado-Machuca, Efren Murillo-Zamora, Jose A Toscano-Velazquez, Josuel Delgado-Enciso, Valery Melnikov, Mireya Walle-Guillen, Hector R Galvan-Salazar, Osiris G Delgado-Enciso, Ariana Cabrera-Licona, Eduardo J Danielewicz-Mata, Pablo J Mandujano-Diaz, José Guzman-Esquivel, Daniel A Montes-Galindo, Henry Perez-Martinez, Jesus M Jimenez-Villegaz, Alejandra E Hernandez-Rangel, Patricia Montes-Diaz, Iram P Rodriguez-Sanchez, Margarita L Martinez-Fierro, Idalia Garza-Veloz, Daniel Tiburcio-Jimenez, Sergio A Zaizar-Fregoso, Fidadelfo Gonzalez-Alcaraz, Laydi Gutierrez-Gutierrez, Luciano Diaz-Lopez, Mario Ramirez-Flores, Hannah P Guzman-Solorzano, Gustavo Gaytan-Sandoval, Carlos R Martinez-Perez, Francisco Espinoza-Gómez, Fabián Rojas-Larios, Michael J Hirsch-Meillon, Luz M Baltazar-Rodriguez, Enrique Barrios-Navarro, Vladimir Oviedo-Rodriguez, Martha A Mendoza-Hernandez, Emilio Prieto-Diaz-Chavez, Brenda A Paz-Michel
Coronavirus disease 2019 (COVID-19) is currently the major public health problem worldwide. Neutral electrolyzed saline solution that contains reactive chlorine and oxygen species may be an effective therapeutic. In the present study, the treatment efficacy of intravenous and/or nebulized neutral electrolyzed saline combined with usual medical care vs. usual medical care alone was evaluated in ambulatory patients with COVID-19. A prospective, 2-arm, parallel-group, randomized, open-label, multi-center, phase I-II clinical trial including 214 patients was performed...
September 2021: Experimental and Therapeutic Medicine
#19
JOURNAL ARTICLE
Carlos I Ponte-Negretti, Fernando S Wyss, Daniel Piskorz, Raul D Santos, Raul Villar, Alberto Lorenzatti, Patricio López-Jaramillo, Peter P. Toth, A Juan J Amaro, Alfonso K Rodrigo, Fernando Lanas, Miguel Urina-Triana, Jofre Lara, T Osiris Valdés, José R Gomez-Mancebo, Alfonso Bryce, Leonardo Cobos S, Adriana Puente-Barragan, Vladimir E Ullauri-Solórzano, Felix A Medina-Palomino, Alfredo F Lozada, Maritza Duran, Percy Berrospi, David Miranda, Juan J Badimon, J José R González, Peter Libby
BACKGROUND: Hypertension, hyperglycemia, dyslipidemia, overweight, obesity, and tobacco (smoking, chewing, and vaping), together with a pro-inflammatory and procoagulant state, are the main risk factors related to atherosclerotic cardiovascular disease. OBJECTIVE AND METHODS: A group of experts from the Americas, based on their clinical expertise in cardiology, cardiovascular prevention, and cardiometabolic (CM) diseases, joined together to develop these practical recommendations for the optimal evaluation and treatment of residual CM risk factors in Latin America, using a modified Delphi methodology (details in electronic TSI) to generate a comprehensive CM risk reduction guideline, and through personalized medicine and patient-centered decision, considering the cost-benefit ratio The process was well defined to avoid conflicts of interest that could bias the discussion and recommendations...
January 3, 2022: Archivos de Cardiología de México
#20
JOURNAL ARTICLE
Valery Melnikov, Daniel Tiburcio-Jimenez, Martha A Mendoza-Hernandez, Josuel Delgado-Enciso, Luis De-Leon-Zaragoza, Jose Guzman-Esquivel, Iram P Rodriguez-Sanchez, Margarita L Martinez-Fierro, Agustin Lara-Esqueda, Osiris G Delgado-Enciso, Ivan Jacinto-Cortes, Sergio A Zaizar-Fregoso, Brenda A Paz-Michel, Efren Murillo-Zamora, Ivan Delgado-Enciso, Hector R Galvan-Salazar
Inflammation is an essential component of prostate cancer (PCa), and mefenamic acid has been reported to decrease its biochemical progression. The current standard therapy for PCa is androgen deprivation therapy (ADT), which has side effects such as cognitive dysfunction, risk of Alzheimer's disease, and dementia. Published results of in vitro tests and animal models studies have shown that mefenamic acid could be used as a neuroprotector. Objective: Examine the therapeutic potential of mefenamic acid in cognitive impairment used in a controlled clinical trial...
2021: American Journal of Translational Research
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