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JOURNAL ARTICLE
Lisa Pilgram, Thierry Meurers, Bradley Malin, Elke Schaeffner, Kai-Uwe Eckardt, Fabian Prasser
BACKGROUND: Sharing data from clinical studies can accelerate scientific progress, improve transparency, and increase the potential for innovation and collaboration. However, privacy concerns remain a barrier to data sharing. Certain concerns, such as reidentification risk, can be addressed through the application of anonymization algorithms, whereby data are altered so that it is no longer reasonably related to a person. Yet, such alterations have the potential to influence the data set's statistical properties, such that the privacy-utility trade-off must be considered...
April 24, 2024: Journal of Medical Internet Research
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JOURNAL ARTICLE
Abdulnaser Nourallah, Abdulrahman Alshehri, Ayman Alhejazi, Binyam Usman, Ghada ElGohary, Hafiz Malhan, Ibraheem Motabi, Khalil Al Farsi, Mohammed Alshuaibi, Mustaqeem Siddiqui, Rasha Ghonema, Ruba Yasin Taha, Tarek Abouzeid, Wesam Ahmed, Mohanad Diab, Ahmad Alhuraiji, Magdy Rabea, Mohamed Zahir Chouikrat
BACKGROUND: Multiple myeloma (MM) is the second-most common cancer among hematological malignancies. Patients with active disease may experience several comorbidities, including renal insufficiency and asthma, which may lead to treatment failure. The treatment of relapsed or refractory MM (RRMM) has been associated with multiple factors, causing a decline in progression-free survival as well as overall survival with subsequent lines of therapy. Data about the characteristics of this group of patients in the Greater Gulf region are lacking...
April 24, 2024: JMIR Research Protocols
#3
JOURNAL ARTICLE
Francesco Bagnasco, Camilla Canepa, Paolo Pesce, Giada Rezzano, Nicoletta Contegiacomo, Maria Menini
PURPOSE: To evaluate peri-implant tissue health and bone resorption in patients with implant-supported fixed partial rehabilitations. In particular, possible correlations between plaque accumulation and bone loss, as well as other periimplant health parameters, were investigated. MATERIALS AND METHODS: A total of 44 patients rehabilitated with fixed implant-supported partial rehabilitations were included. The following parameters were recorded: spontaneous bleeding (SB), suppuration, bleeding on probing (BOP), plaque index (PI), and probing depth (PD)...
April 24, 2024: International Journal of Oral & Maxillofacial Implants
#4
COMPARATIVE STUDY
A D Navarro-Vergara, A S Portillo-Candia, C L Sánchez-Silva, R A Arréllaga-Alonso, A A Portillo-Vanni
INTRODUCTION: health promotion policy requires the identification of barriers to the adoption of public policies. Paraguay's national healthcare system is inequitable, expensive, and inefficient. The Ministry of Public Health and Social Welfare (MSPyBS) is the entity responsible for covering the needs of a significant portion of the population. In January 2022, the MSPyBS financed the purchase of titanium elastic nails through a National Public Tender for Osteosynthesis Materials (LPN 02/22) to provide them for free in the pediatric service...
2024: Acta Ortopédica Mexicana
#5
JOURNAL ARTICLE
Yuta Ito, Amira Marouf, Yasunori Kogure, Junji Koya, Raphaël Liévin, Julie Bruneau, Mariko Tabata, Yuki Saito, Sumito Shingaki, Mitsuhiro Yuasa, Kentaro Yamaguchi, Koichi Murakami, Robert Weil, Manon Vavasseur, Guillaume P Andrieu, Mehdi Latiri, Layla Veleanu, Michaël Dussiot, Isabelle André, Akshay Joshi, Chantal Lagresle-Peyrou, Aude Magerus, Sammara Chaubard, David Lavergne, Emmanuel Bachy, Erika Brunet, Virginie Fataccioli, Chantal Brouzes, Camille Laurent, Laurence De Leval, Alexandra Traverse-Glehen, Céline Bossard, Marie-Cécile Parrens, Véronique Meignin, Laure Philippe, Julien Rossignol, Felipe Suarez, Jean-Marie Michot, Olivier Tournilhac, Gandhi Damaj, François Lemonnier, Christine Bôle-Feysot, Patrick Nitschké, Bruno Tesson, Cécile Laurent, Thierry Molina, Vahid Asnafi, Yosaku Watatani, Kenichi Chiba, Ai Okada, Yuichi Shiraishi, Sachiko Tsukita, Koji Izutsu, Hiroaki Miyoshi, Koichi Ohshima, Seiji Sakata, Akito Dobashi, Kengo Takeuchi, Masashi Sanada, Philippe Gaulard, Arnaud Jaccard, Seishi Ogawa, Olivier Hermine, Keisuke Kataoka, Lucile Couronné
Extranodal NK/T-cell lymphoma (ENKTCL) is an Epstein-Barr virus (EBV)-related neoplasm with male dominance and a poor prognosis. A better understanding of the genetic alterations and their functional roles in ENKTCL could help improve patient stratification and treatments. Here, we performed comprehensive genetic analysis of 177 ENKTCL cases to delineate the landscape of mutations, copy number alterations (CNAs), and structural variations, identifying 34 driver genes including six previously unappreciated ones, namely HLA-B, HLA-C, ROBO1, CD58, POT1, and MAP2K1...
April 24, 2024: Cancer Research
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JOURNAL ARTICLE
Remy Hoek Spaans, Albert Mkumbwa, Peter Nasoni, Christopher M Jones, Michelle C Stanton
Indoor residual spraying (IRS) is one of the main vector control tools used in malaria prevention. This study evaluates IRS in the context of a privately run campaign conducted across a low-lying, irrigated, sugarcane estate from Illovo Sugar, in the Chikwawa district of Malawi. The effect of Actellic 300CS annual spraying over four years (2015-2018) was assessed using a negative binomial mixed effects model, in an area where pyrethroid resistance has previously been identified. With an unadjusted incidence rate ratio (IRR) of 0...
2024: PLOS Glob Public Health
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JOURNAL ARTICLE
Sheina Tarlovski, Anat Bar Kadmon, Eran Goldberg, Dadi Segal, Dov Gavish, David Stepensky
Background: Over the last years, there is a dramatic increase in the use of medical cannabis products for an expanding range of clinical indications. The type of the drug product and its administration route affect substantially the rate and the extent of absorption of cannabinoids and the effects induced by them in the patients. The current challenge for the cannabis pharmaceutical industry is to develop formulations that allow predictable and stable absorption of cannabinoids. This article reports the results of the clinical trial that investigated the pharmacokinetics (PKs) of innovative cannabis products in healthy volunteers...
April 24, 2024: Cannabis and Cannabinoid Research
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JOURNAL ARTICLE
Birgith Engelst Grove, Annette de Thurah, Per Ivarsen, Ann Katrine Kvisgaard, Niels Henrik Hjollund, Regine Grytnes, Liv Marit Valen Schougaard
BACKGROUND: In Denmark, outpatient follow-up for patients with chronic kidney disease (CKD) is changing from in-hospital visits toward more remote health care delivery. The nonuse of remote patient-reported outcomes (PROs) is a well-known challenge, and it can be difficult to explain which mechanisms of interventions influence the outcome. Process evaluation may, therefore, be used to answer important questions on how and why interventions work, aiming to enhance the implications for clinical practice...
April 24, 2024: JMIR Formative Research
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JOURNAL ARTICLE
Jiayi Lin, Hrayer Aprahamian, George Golovko
We consider the problem of targeted mass screening of heterogeneous populations under limited testing capacity. Mass screening is an essential tool that arises in various settings, e.g., ensuring a safe supply of blood, reducing prevalence of sexually transmitted diseases, and mitigating the spread of infectious disease outbreaks. The goal of mass screening is to classify whole population groups as positive or negative for an infectious disease as efficiently and accurately as possible. Under limited testing capacity, it is not possible to screen the entire population and hence administrators must reserve testing and target those among the population that are most in need or most susceptible...
April 24, 2024: Health Care Management Science
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JOURNAL ARTICLE
María Suárez-Redondo, Manuel Fuertes-Recuero, Alba Guzmán-Soltero, Delia Aguado, María Del Carmen Martín-Espada, Jorge Espinel-Rupérez, Gustavo Ortiz-Diez
Mastectomy is a common and painful procedure in dogs. Wound soaker catheters (WSC) are frequently used to reduce postoperative pain, including pain after mastectomy. The objectives of this case series were to describe the use of WSC for owner administration of postoperative local analgesia in dogs with mammary tumors treated surgically, to identify complications associated with WSC and to determine the frequency of bacterial colonization of the catheters. Twelve WSC were placed in 11 dogs during mastectomy surgery, left in place for three days, protected by a dressing and successfully managed by owners at home...
April 24, 2024: Veterinary Research Communications
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JOURNAL ARTICLE
James W Antoon, Tess Stopczynski, Justin Z Amarin, Laura S Stewart, Julie A Boom, Leila C Sahni, Marian G Michaels, John V Williams, Janet A Englund, Eileen J Klein, Mary A Staat, Elizabeth P Schlaudecker, Rangaraj Selvarangan, Jennifer E Schuster, Geoffrey A Weinberg, Peter G Szilagyi, Ariana Perez, Heidi L Moline, Andrew J Spieker, Carlos G Grijalva, Samantha M Olson, Natasha B Halasa
IMPORTANCE: Studies of influenza in children commonly rely on coded diagnoses, yet the ability of International Classification of Diseases, Ninth Revision codes to identify influenza in the emergency department (ED) and hospital is highly variable. The accuracy of newer International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10) codes to identify influenza in children is unknown. OBJECTIVE: To determine the accuracy of ICD-10 influenza discharge diagnosis codes in the pediatric ED and inpatient settings...
April 1, 2024: JAMA Network Open
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JOURNAL ARTICLE
Zhibin Tan, Daryl Yin Keong Lo, Kaavya Narasimhalu
INTRODUCTION: Conus medullaris infarction (CMI) is a rare vascular phenomenon that has been scarcely reported in the literature. While previous studies have described the clinical and radiological features of CMI, little attention has been paid to its associated neurophysiological findings. METHODS: We present a case of idiopathic CMI and its neurophysiological findings, then present our findings from a systematic review of other reports of CMI with neurophysiological features found via PubMed search...
April 24, 2024: Acta Neurologica Belgica
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JOURNAL ARTICLE
Xiaoxia Zhang, Yujie Wei, Fanqi Wu, Mei Li, Cong Han, Chengdong Huo, Zhi Li, Futian Tang, Wenting He, Yang Zhao, Yumin Li
PURPOSE: Gastric cancer (GC) is prevalent as one of the most common malignant tumors globally, with a particularly high incidence in China. The role of UBE2L3 in the initiation and progression of various cancers has been well documented, but its specific significance in GC is not yet fully elucidated. The objective of this study is to examine the expression and importance of UBE2L3 in human gastric cancer tissues. METHODS: Immunohistochemical staining and survival analysis were conducted on 125 cases of GC...
April 24, 2024: Journal of Cancer Research and Clinical Oncology
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JOURNAL ARTICLE
Greg Noe, Kaushal Shah, Samantha Ongchuan, Sahil Munjal
BACKGROUND: Among prescribers, bupropion is considered a substance of low misuse potential, with some studies showing lesser misuse potential than caffeine. However, several case reports exist of recreational bupropion misuse and diversion. Our goal is to understand at-risk populations, clinical courses, interventions, and outcomes after acute ingestion of bupropion via oral, intravenous route, and insufflation. METHODS: The systematic review was registered with PROSPERO on August 5, 2023...
April 24, 2024: Journal of Clinical Psychopharmacology
#15
JOURNAL ARTICLE
Yi Jin, Cuiyang Feng, Rong Yuan, Jialiang Yang, Paul Behrens
Large volumes of water are used in energy production for both primary (e.g., fuel extraction) and secondary energy (e.g., electricity). In countries such as China, with a large internal trade in fuels and long-distance transmission grids, this can result in considerable water inequalities. Previous research focused on the water impacts of energy production at the national and provincial levels, which is too coarse to identify the spatial differences and make specific case studies. Here, we take the next step toward a spatially explicit economically integrated water-use for energy assessment by combining a bottom-up assessment approach with a city-level multiregional input-output model...
April 24, 2024: Environmental Science & Technology
#16
JOURNAL ARTICLE
Anquan Hu, Heyan Qin, Shina Wu, Xiaolin Zhao, Yumeng Li, Feng Chen, Tao Liu
We aimed to develop a prognostic model for primary pontine hemorrhage (PPH) patients and validate the predictive value of the model for a good prognosis at 90 days. A total of 254 PPH patients were included for screening of the independent predictors of prognosis, and data were analyzed by univariate and multivariable logistic regression tests. The cases were then divided into training cohort (n=219) and validation cohort (n=35) based on the two centers. A nomogram was developed using independent predictors from the training cohort to predict the 90-day good outcome and was validated from the validation cohort...
2024: Brazilian Journal of Medical and Biological Research
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REVIEW
E M S Martins, L C Nascimento da Silva, M S Carmo
Acute diarrhea is the second leading cause of morbidity and mortality attributed to infections in children under five years of age worldwide, with 1.7 million annual estimated cases and more than 500,000 deaths. Although hydroelectrolytic replacement is the gold standard in treating diarrhea, it does not interfere with the restoration of the intestinal microbiota. Several studies have searched for an adequate alternative in restructuring intestinal homeostasis, finding that treatments based on probiotics, prebiotics, and synbiotics are effective, which made such treatments increasingly present in clinical practice by reducing illness duration with minimal side effects...
2024: Brazilian Journal of Medical and Biological Research
#18
JOURNAL ARTICLE
Rocío Santos-Martínez, Elia Nora Arganis Juárez
This study aims to describe and analyze the medical pluralism and the type of hegemony-subordination relation between forms of care or knowledge in the treatment of a patient with glaucoma to show the articulatory and transactional process between several therapeutic resources and understand which structural elements shaped the treatment itinerary and option. This is a qualitative research that used a narrative case study. To reconstruct the narrative, a semi-structured interview was conducted based on a thematic script previously established by a set of a priori categories to later transcribe the data and perform hermeneutic triangulation...
2024: Cadernos de Saúde Pública
#19
JOURNAL ARTICLE
Rebeca Nascimento Dos Santos Mascarenhas, Vitória Valéria Cristo Santos, Bruno Silva de Santana, Anne Alencar Monteiro, Telmara Menezes Couto, Anderson Reis de Sousa, Danilo Martins Roque Pereira, Lilian Conceição Guimarães de Almeida
This study aims to analyze the experiences of a transgender man during the gestational-puerperal period and the perspective of obstetric nurses in training based on the dynamics and organization of obstetric healthcare in a hospital setting. This qualitative study is based on a case study approach, employing interviews and direct observations to collect data. The analysis was based on the theoretical and normative framework of the Nursing Process, the Theory of Caring, and the theoretical/critical perspective of transfeminism...
April 2024: Ciência & Saúde Coletiva
#20
JOURNAL ARTICLE
Undine Falkenhagen, Larisa H Cavallari, Julio D Duarte, Charlotte Kloft, Stephan Schmidt, Wilhelm Huisinga
Warfarin dosing remains challenging due to substantial inter-individual variability, which can lead to unsafe or ineffective therapy with standard dosing. Model-informed precision dosing (MIPD) can help individualize warfarin dosing, requiring the selection of a suitable model. For models developed from clinical data, the dependence on the study design and population raises questions about generalizability. Quantitative system pharmacology (QSP) models promise better extrapolation abilities; however, their complexity and lack of validation on clinical data raise questions about applicability in MIPD...
April 24, 2024: Clinical Pharmacology and Therapeutics
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