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https://www.readbyqxmd.com/read/28432657/in-vitro-assay-for-measuring-real-time-topotecan-release-from-liposomes-release-kinetics-and-cellular-internalization
#1
Roger Gilabert-Oriol, Lina Chernov, Malathi Anantha, Wieslawa H Dragowska, Marcel B Bally
Topotecan is a drug that is under investigation for the treatment of neuroblastoma and has been encapsulated into liposomes to improve its therapeutic efficacy. However, liposomal formulations still need to be optimized for drug retention and new techniques to measure drug release are required to better understand this process. Here, a novel in vitro method based on fluorescence de-quenching and an automated microscopy imaging platform were developed for monitoring, in real time, the release of topotecan from a liposomal formulation...
April 21, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28420898/comparison-of-kidney-function-between-gestational-hypertension-and-preeclampsia
#2
Etsuko Nobumoto, Hisashi Masuyama, Jota Maki, Takeshi Eguchi, Shoko Tamada, Takashi Mitsui, Eriko Eto, Kei Hayata, Yuji Hiramatsu
Although gestational hypertension (GH) is thought to be different from preeclampsia (PE), in Japan GH and PE are usually treated as the same disease (i.e., pregnancy-induced hypertension). Here we sought to determine whether there are any differences in fetal growth and maternal kidney function between pregnancies with PE and those with GH. We retrospectively analyzed 61 GH patients and 60 PE patients with singleton pregnancies who delivered at Okayama University Hospital (2008-2015). We compared maternal and perinatal outcomes and maternal kidney function parameters between the GH and PE pregnancies...
April 2017: Acta Medica Okayama
https://www.readbyqxmd.com/read/28420502/the-impact-of-situation-background-assessment-recommendation-sbar-on-safety-attitudes-in-the-obstetrics-department
#3
Wan-Hua Ting, Fu-Shiang Peng, Ho-Hsiung Lin, Sheng-Mou Hsiao
OBJECTIVE: Previous studies evaluating the situation-background-assessment-recommendation (SBAR) have been shown to increase effective nurse-physician communication and collaboration. The purpose of this study is to evaluate the impact of the SBAR technique on safety attitudes in the obstetrics department. MATERIALS AND METHODS: This study implemented the SBAR Collaborative Communication Education course and was conducted in a medical center from February 2012 to March 2015, which included an educational session on fetal heart rate monitoring, a case-based discussion, and a video demonstration on traditional and SBAR communication...
April 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28420215/a-phonocardiographic-based-fiber-optic-sensor-and-adaptive-filtering-system-for-noninvasive-continuous-fetal-heart-rate-monitoring
#4
Radek Martinek, Jan Nedoma, Marcel Fajkus, Radana Kahankova, Jaromir Konecny, Petr Janku, Stanislav Kepak, Petr Bilik, Homer Nazeran
This paper focuses on the design, realization, and verification of a novel phonocardiographic- based fiber-optic sensor and adaptive signal processing system for noninvasive continuous fetal heart rate (fHR) monitoring. Our proposed system utilizes two Mach-Zehnder interferometeric sensors. Based on the analysis of real measurement data, we developed a simplified dynamic model for the generation and distribution of heart sounds throughout the human body. Building on this signal model, we then designed, implemented, and verified our adaptive signal processing system by implementing two stochastic gradient-based algorithms: the Least Mean Square Algorithm (LMS), and the Normalized Least Mean Square (NLMS) Algorithm...
April 18, 2017: Sensors
https://www.readbyqxmd.com/read/28419111/time-resolved-and-label-free-monitoring-of-extracellular-metabolites-by-surface-enhanced-raman-spectroscopy
#5
Victoria Shalabaeva, Laura Lovato, Rosanna La Rocca, Gabriele C Messina, Michele Dipalo, Ermanno Miele, Michela Perrone, Francesco Gentile, Francesco De Angelis
Metabolomics is an emerging field of cell biology that aims at the comprehensive identification of metabolite levels in biological fluids or cells in a specific functional state. Currently, the major tools for determining metabolite concentrations are mass spectrometry coupled with chromatographic techniques and nuclear magnetic resonance, which are expensive, time consuming and destructive for the samples. Here, we report a time resolved approach to monitor metabolite dynamics in cell cultures, based on Surface Enhanced Raman Scattering (SERS)...
2017: PloS One
https://www.readbyqxmd.com/read/28410419/the-electrical-heart-axis-and-st-events-in-fetal-monitoring-a-post-hoc-analysis-following-a-multicentre-randomised-controlled-trial
#6
Rik Vullings, Kim M J Verdurmen, Alexandra D J Hulsenboom, Stephanie Scheffer, Hinke de Lau, Anneke Kwee, Pieter F F Wijn, Isis Amer-Wåhlin, Judith O E H van Laar, S Guid Oei
OBJECTIVE: Reducing perinatal morbidity and mortality is one of the major challenges in modern health care. Analysing the ST segment of the fetal electrocardiogram was thought to be the breakthrough in fetal monitoring during labour. However, its implementation in clinical practice yields many false alarms and ST monitoring is highly dependent on cardiotocogram assessment, limiting its value for the prediction of fetal distress during labour. This study aims to evaluate the relation between physiological variations in the orientation of the fetal electrical heart axis and the occurrence of ST events...
2017: PloS One
https://www.readbyqxmd.com/read/28407851/time-dependent-changes-and-prognostic-value-of-lactatemia-during-the-first-24%C3%A2-h-of-life-in-brachycephalic-newborn-dogs
#7
C Castagnetti, M Cunto, C Bini, J Mariella, S Capolongo, D Zambelli
Blood lactate concentration is known to be a good prognostic indicator associated with the severity of illness and the patient's outcome both in human and veterinary medicine. It also plays a significant role in the assessment of the newborn, being a good indicator of fetal hypoxia and the ideal predictor of morbidity at term in babies. In veterinary neonatal medicine, hyperlactatemia is considered a valid prognostic marker in critically ill foals; moreover, blood lactate measurement has been proposed for the evaluation of newborn viability and the assessment of fetal distress during delivery in dogs...
May 2017: Theriogenology
https://www.readbyqxmd.com/read/28405345/lower-glycemic-load-meals-reduce-diurnal-glycemic-oscillations-in-women-with-risk-factors-for-gestational-diabetes
#8
Nathalie V Kizirian, Janina Goletzke, Shannon Brodie, Fiona S Atkinson, Tania P Markovic, Glynis P Ross, Anette Buyken, Jennie P Brand-Miller
OBJECTIVE: Maternal glycemia plays a key role in fetal growth. We hypothesized that lower glycemic load (GL) meals (lower glycemic index, modestly lower carbohydrate) would substantially reduce day-long glucose variability in women at risk of gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS: A crossover study of 17 women (mean±SD age 34.8±4 years; gestational weeks 29.3±1.3; body mass index 23.8±4.7 kg/m(2)) who consumed a low GL or a high GL diet in random order, 1-day each, over 2 consecutive days...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28403965/understanding-fetal-physiology-and-second-line-monitoring-during-labor
#9
REVIEW
C Garabedian, J De Jonckheere, L Butruille, P Deruelle, L Storme, V Houfflin-Debarge
Cardiotocography (CTG) is a technique used to monitor intrapartum fetal condition and is one of the most common obstetric procedures. Second line methods of fetal monitoring have been developed in an attempt to reduce unnecessary interventions due to continuous cardiotocography and to better identify fetuses at risk of intrapartum asphyxia. The acid-base balance of the fetus is evaluated by fetal blood scalp samples, the modification of the myocardial oxygenation by the fetal ECG ST-segment analysis (STAN) and the autonomic nervous system by the power spectral analysis of the fetal heart variability...
February 2017: J Gynecol Obstet Hum Reprod
https://www.readbyqxmd.com/read/28403428/maternal-and-fetal-outcomes-of-admission-for-delivery-in-women-with-congenital-heart-disease
#10
Robert M Hayward, Elyse Foster, Zian H Tseng
Background: Women with congenital heart disease (CHD) may be at increased risk for adverse events during pregnancy and delivery. Objective: To compare delivery outcomes between women with and without CHD. Design, Setting, and Participants: This retrospective study of inpatient delivery admissions in the Healthcare Cost and Utilization Project's California State Inpatient Database compared maternal and fetal outcomes between women with and without CHD by using multivariate logistic regression...
April 12, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28401353/maternal-fetal-loss-history-and-increased-acute-leukemia-subtype-risk-in-subsequent-offspring-a-systematic-review-and-meta-analysis
#11
REVIEW
M A Karalexi, N Dessypris, A Skalkidou, S -I Biniaris-Georgallis, Ε Ι Kalogirou, T P Thomopoulos, E Herlenius, L G Spector, D Loutradis, G P Chrousos, E Th Petridou
PURPOSE: History of fetal loss including miscarriage and stillbirth has been inconsistently associated with childhood (0-14 years) leukemia in subsequent offspring. A quantitative synthesis of the inconclusive literature by leukemia subtype was therefore conducted. METHODS: Eligible studies (N = 32) were identified through the screening of over 3500 publications. Random-effects meta-analyses were conducted on the association of miscarriage/stillbirth history with overall (AL; 18,868 cases/35,685 controls), acute lymphoblastic (ALL; 16,150 cases/38,655 controls), and myeloid (AML; 3042 cases/32,997 controls) leukemia...
April 11, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28398679/ebola-virus-disease-and-pregnancy-a-review-of-the-current-knowledge-of-ebola-virus-pathogenesis-maternal-and-neonatal-outcomes
#12
REVIEW
Lisa M Bebell, Titilope Oduyebo, Laura E Riley
The 2014 to 2016 Ebola virus disease (EVD) outbreak in West Africa devastated local health systems and caused thousands of deaths. Historical reports from Zaire ebolavirus outbreaks suggested pregnancy was associated with an increased risk of severe illness and death, with mortality rates from 74 to 100%. In total, 111 cases of pregnant patients with EVD are reported in the literature, with an aggregate maternal mortality of 86%. Pregnancy-specific data published from the recent outbreak include four small descriptive cohort studies and five case reports...
March 15, 2017: Birth Defects Res
https://www.readbyqxmd.com/read/28395331/immune-response-to-a-model-shared-placenta-tumor-associated-antigen-reduces-cancer-risk-in-parous-mice%C3%A2
#13
Susmita Jasti, Mina Farahbakhsh, Sean Nguyen, Brian K Petroff, Margaret G Petroff
During human pregnancy, paternally inherited antigens expressed by the fetal-placental unit can elicit expansion of antigen-specific CD8+ T cells. These cells can persist for years as memory T cells, but their effects on long-term maternal health are unknown. Shared placenta/tumor-associated antigens are expressed by placenta and tumors, but are minimally expressed or absent in normal adult tissues. We hypothesized that maternal T cells elicited against these antigens can alter risk of cancers expressing the same antigen after pregnancy, and tested this in mice using chicken ovalbumin (OVA) as a surrogate shared placenta/tumor antigen...
January 1, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28392944/monitoring-fetal-heart-rate-during-labor-a-comparison-of-three-methods
#14
Tammy Y Euliano, Shalom Darmanjian, Minh Tam Nguyen, John D Busowski, Neil Euliano, Anthony R Gregg
The purpose of the study was to compare the accuracy of a noninvasive fetal heart rate monitor with that of ultrasound, using a fetal scalp electrode as the gold standard, in laboring women of varying body habitus, throughout labor and delivery. Laboring women requiring fetal scalp electrode were monitored simultaneously with the investigational device (noninvasive fetal ECG), ultrasound, and fetal scalp electrode. An algorithm extracted the fetal heart rate from the noninvasive fetal ECG signal. Each noninvasive device recording was compared with fetal scalp electrode with regard to reliability by positive percent agreement and accuracy by root mean squared error...
2017: Journal of Pregnancy
https://www.readbyqxmd.com/read/28391212/tracking-fetal-movement-through-source-localization-from-multisensor-magnetocardiographic-recordings
#15
Recep Avci, James Wilson, Diana Escalona-Vargas, Hari Eswaran
Due to its high spatial and temporal resolution, fetal magnetocardiography (fMCG) measurements have been used for fetal movement (FM) detection in several studies which considered the changes in the amplitude and/or morphology of measured fMCG signals. Using source localization for fMCG measurements, we propose a novel method to fit a magnetic dipole moment to fetal heart signals and investigate the positional changes of magnetic dipole in order to detect FMs. We first split each fMCG recording into 6-second time windows...
April 4, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28390564/systemic-lupus-erythematosus-and-pregnancy
#16
REVIEW
Aisha Lateef, Michelle Petri
Systemic lupus erythematosus (SLE) is an autoimmune disease with a strong female predilection. Pregnancy remains a commonly encountered but high-risk situation in this setting. Both maternal and fetal mortality and morbidity are still significantly increased despite improvements in outcomes. Maternal morbidity includes higher risk of disease flares, preeclampsia and other pregnancy-related complications. Fetal issues include higher rates of preterm birth, intrauterine growth restriction, and neonatal lupus syndromes...
May 2017: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/28390562/preconception-counseling
#17
REVIEW
Monika Østensen
Chronic rheumatic disease may interfere with procreation in women of childbearing age. Female patients should have counseling in regard to family planning and parenting. Preconception counseling requires risk assessment of possible maternal or fetal risks, screening for biomarkers with predictive value for adverse pregnancy outcomes, adjustment of therapy, and a schedule for monitoring and follow-up during pregnancy. Delivering comprehensive information and addressing all patient concerns are both essential for enabling patients to engage actively in decision making...
May 2017: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/28384079/maternal-cancer-during-pregnancy-and-risks-of-stillbirth-and-infant-mortality
#18
Donghao Lu, Jonas F Ludvigsson, Karin E Smedby, Katja Fall, Unnur Valdimarsdóttir, Sven Cnattingius, Fang Fang
Purpose To examine whether maternal cancer during pregnancy is associated with increased risks of stillbirth and infant mortality. Methods On the basis of nationwide health registers, we conducted a study of 3,947,215 singleton births in Sweden from 1973 through 2012. Exposure was defined as maternal cancer diagnosed during pregnancy (number of births = 984) or during the year after pregnancy (number of births = 2,723). We calculated incidence rate ratios (IRRs) for stillbirth and infant mortality, comparing exposed births to unexposed births...
March 6, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28383834/-vaginal-delivery-of-bi-scarred-uterus
#19
REVIEW
Y Christiane, P Emonts
Despite awareness of obstetricians to the constant increase in the number of caesarean sections in recent years, certain dogmas concerning uterine scar still persist in our practices and influence clinical decisions. Fear of a uterine scar rupture, a major obstetric complication, is always in mind. As for bi-uterine scar, it was considered, until recently in Belgium, as a full and definitive indication against an attempted vaginal delivery. However, several previous clinical studies clearly showed that, under certain conditions, vaginal birth after two caesarean sections was usually successful with very good results in terms of maternal and fetal morbidities...
September 2016: Revue Médicale de Liège
https://www.readbyqxmd.com/read/28381180/follow-up-of-gestational-trophoblastic-disease-neoplasia-via-quantification-of-circulating-nucleic-acids-of-placental-origin-using-c19mc-micrornas-hypermethylated-rassf1a-and-sry-sequences
#20
Ilona Hromadnikova, Katerina Kotlabova, Ladislav Krofta, Filip Hron
The aim of the study was to evaluate the effectiveness of placental-specific markers, extracellular fetal DNA (sex-determining region Y and hypermethylated RASSF1A sequences) and circulating C19MC microRNAs (miR-516-5p, miR-517-5p, miR-518b, miR-520a-5p, miR-520h, miR-525, and miR-526a) for the diagnosis and consecutive follow-up of gestational trophoblastic disease/neoplasia. Increased levels of extracellular fetal DNA and C19MC microRNAs were detected in patients with active disease when compared with the period when the patients reached remission of the disease...
April 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
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