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JOURNAL ARTICLE
Yu Fujiwara, Shumei Kato, Daisuke Nishizaki, Hirotaka Miyashita, Suzanna Lee, Mary K Nesline, Jeffrey M Conroy, Paul DePietro, Sarabjot Pabla, Scott M Lippman, Razelle Kurzrock
Indoleamine 2,3-dioxygenase 1 (IDO1), which catabolizes tryptophan, is a potential target to unlock the immunosuppressive tumor microenvironment. Correlations between IDO1 and immune checkpoint inhibitor (ICI) efficacy remain unclear. Herein, we investigated IDO1 transcript expression across cancers and clinical outcome correlations. High IDO1 transcripts were more frequent in uterine (54.2%) and ovarian cancer (37.2%) but varied between and within malignancies. High IDO1 RNA expression was associated with high expression of PD-L1 (immune checkpoint ligand), CXCL10 (an effector T cell recruitment chemokine), and STAT1 (a component of the JAK-STAT pathway) (all multivariable p < 0...
April 19, 2024: IScience
#2
JOURNAL ARTICLE
Louise Emmett, Shalini Subramaniam, Megan Crumbaker, Andrew Nguyen, Anthony M Joshua, Andrew Weickhardt, Sze-Ting Lee, Siobhan Ng, Roslyn J Francis, Jeffrey C Goh, David A Pattison, Thean Hsiang Tan, Ian D Kirkwood, Craig Gedye, Natalie K Rutherford, Shahneen Sandhu, Aravind Ravi Kumar, David Pook, Shakher Ramdave, David P Nadebaum, Mark Voskoboynik, Andrew D Redfern, William Macdonald, Laurence Krieger, Geoff Schembri, Wei Chua, Peter Lin, Lisa Horvath, Patricia Bastick, Patrick Butler, Alison Yan Zhang, Sonia Yip, Hayley Thomas, Ailsa Langford, Michael S Hofman, Margaret McJannett, Andrew James Martin, Martin R Stockler, Ian D Davis
BACKGROUND: Enzalutamide and lutetium-177 [177 Lu]Lu-prostate-specific membrane antigen (PSMA)-617 both improve overall survival in patients with metastatic castration-resistant prostate cancer. Androgen and PSMA receptors have a close intracellular relationship, with data suggesting complementary benefit if targeted concurrently. In this study, we assessed the activity and safety of enzalutamide plus adaptive-dosed [177 Lu]Lu-PSMA-617 versus enzalutamide alone as first-line treatment for metastatic castration-resistant prostate cancer...
April 12, 2024: Lancet Oncology
#3
Suying Liu, Sarah E Adams, Haotian Zheng, Juliana Ehnot, Seul K Jung, Greer Jeffrey, Theresa Menna, Louise E Purton, Hongzhe Lee, Peter Kurre
Hematopoietic dysfunction has been associated with a reduction in the number of active precursors. However, precursor quantification at homeostasis and under diseased conditions is constrained by the scarcity of available methods. To address this issue, we optimized a method for quantifying a wide range of hematopoietic precursors. Assuming the random induction of a stable label in precursors following a binomial distribution, the estimation depends on the inverse correlation between precursor numbers and the variance of precursor labeling among independent samples...
April 3, 2024: bioRxiv
#4
Samantha Madala, Yicheng K Bao, Jun Hui Lee, Jeffrey Gluckstein, Jessica Chang, Sandy Zhang-Nunes
PURPOSE: To report a case of retrograde embolism of cosmetic injection of platelet-rich plasma (PRP) to the ophthalmic artery, resulting in orbital ischemia, blindness, and eventual phthisis bulbi. OBSERVATIONS: A 37-year-old woman presented with two days of vision loss OS beginning seconds after undergoing cosmetic PRP filler injections to the face at an outside clinic. Immediately after injection to the left medial forehead, the patient reported bleeding, transient loss of consciousness, and complete vision loss OS...
June 2024: American Journal of Ophthalmology Case Reports
#5
JOURNAL ARTICLE
Yue Zhou, Gregory A Phelps, Mikayla M Mangrum, Jemma McLeish, Elise K Phillips, Jinchao Lou, Christelle F Ancajas, Jeffrey M Rybak, Peter M Oelkers, Richard E Lee, Michael D Best, Todd B Reynolds
UNLABELLED: Systemic infections by Candida spp. are associated with high mortality rates, partly due to limitations in current antifungals, highlighting the need for novel drugs and drug targets. The fungal phosphatidylserine synthase, Cho1, from Candida albicans is a logical antifungal drug target due to its importance in virulence, absence in the host, and conservation among fungal pathogens. Inhibitors of Cho1 could serve as lead compounds for drug development, so we developed a target-based screen for inhibitors of purified Cho1...
April 9, 2024: MBio
#6
Aaron M Miller, Jonathan M Holmes, Rui Wu, Raymond T Kraker, Eric R Crouch, Katherine A Lee, Monte A Del Monte, Justin D Marsh, Courtney L Kraus, David K Wallace, Jeffrey D Colburn, Pavlina S Kemp, Susan A Cotter
No abstract text is available yet for this article.
April 2, 2024: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
#7
JOURNAL ARTICLE
E Rosenberg, T I Andersen, R Samajdar, A Petukhov, J C Hoke, D Abanin, A Bengtsson, I K Drozdov, C Erickson, P V Klimov, X Mi, A Morvan, M Neeley, C Neill, R Acharya, R Allen, K Anderson, M Ansmann, F Arute, K Arya, A Asfaw, J Atalaya, J C Bardin, A Bilmes, G Bortoli, A Bourassa, J Bovaird, L Brill, M Broughton, B B Buckley, D A Buell, T Burger, B Burkett, N Bushnell, J Campero, H-S Chang, Z Chen, B Chiaro, D Chik, J Cogan, R Collins, P Conner, W Courtney, A L Crook, B Curtin, D M Debroy, A Del Toro Barba, S Demura, A Di Paolo, A Dunsworth, C Earle, L Faoro, E Farhi, R Fatemi, V S Ferreira, L Flores Burgos, E Forati, A G Fowler, B Foxen, G Garcia, É Genois, W Giang, C Gidney, D Gilboa, M Giustina, R Gosula, A Grajales Dau, J A Gross, S Habegger, M C Hamilton, M Hansen, M P Harrigan, S D Harrington, P Heu, G Hill, M R Hoffmann, S Hong, T Huang, A Huff, W J Huggins, L B Ioffe, S V Isakov, J Iveland, E Jeffrey, Z Jiang, C Jones, P Juhas, D Kafri, T Khattar, M Khezri, M Kieferová, S Kim, A Kitaev, A R Klots, A N Korotkov, F Kostritsa, J M Kreikebaum, D Landhuis, P Laptev, K-M Lau, L Laws, J Lee, K W Lee, Y D Lensky, B J Lester, A T Lill, W Liu, A Locharla, S Mandrà, O Martin, S Martin, J R McClean, M McEwen, S Meeks, K C Miao, A Mieszala, S Montazeri, R Movassagh, W Mruczkiewicz, A Nersisyan, M Newman, J H Ng, A Nguyen, M Nguyen, M Y Niu, T E O'Brien, S Omonije, A Opremcak, R Potter, L P Pryadko, C Quintana, D M Rhodes, C Rocque, N C Rubin, N Saei, D Sank, K Sankaragomathi, K J Satzinger, H F Schurkus, C Schuster, M J Shearn, A Shorter, N Shutty, V Shvarts, V Sivak, J Skruzny, W Clarke Smith, R D Somma, G Sterling, D Strain, M Szalay, D Thor, A Torres, G Vidal, B Villalonga, C Vollgraff Heidweiller, T White, B W K Woo, C Xing, Z Jamie Yao, P Yeh, J Yoo, G Young, A Zalcman, Y Zhang, N Zhu, N Zobrist, H Neven, R Babbush, D Bacon, S Boixo, J Hilton, E Lucero, A Megrant, J Kelly, Y Chen, V Smelyanskiy, V Khemani, S Gopalakrishnan, T Prosen, P Roushan
Understanding universal aspects of quantum dynamics is an unresolved problem in statistical mechanics. In particular, the spin dynamics of the one-dimensional Heisenberg model were conjectured as to belong to the Kardar-Parisi-Zhang (KPZ) universality class based on the scaling of the infinite-temperature spin-spin correlation function. In a chain of 46 superconducting qubits, we studied the probability distribution of the magnetization transferred across the chain's center, [Formula: see text]. The first two moments of [Formula: see text] show superdiffusive behavior, a hallmark of KPZ universality...
April 5, 2024: Science
#8
JOURNAL ARTICLE
Paolo Cadinu, Kisha N Sivanathan, Aditya Misra, Rosalind J Xu, Davide Mangani, Evan Yang, Joseph M Rone, Katherine Tooley, Yoon-Chul Kye, Lloyd Bod, Ludwig Geistlinger, Tyrone Lee, Randall T Mertens, Noriaki Ono, Gang Wang, Liliana Sanmarco, Francisco J Quintana, Ana C Anderson, Vijay K Kuchroo, Jeffrey R Moffitt, Roni Nowarski
Gut inflammation involves contributions from immune and non-immune cells, whose interactions are shaped by the spatial organization of the healthy gut and its remodeling during inflammation. The crosstalk between fibroblasts and immune cells is an important axis in this process, but our understanding has been challenged by incomplete cell-type definition and biogeography. To address this challenge, we used multiplexed error-robust fluorescence in situ hybridization (MERFISH) to profile the expression of 940 genes in 1...
April 1, 2024: Cell
#9
JOURNAL ARTICLE
Jeffrey K Lee, Abhik Roy, Christopher D Jensen, Jennifer T Chan, Wei K Zhao, Theodore R Levin, Jessica Chubak, Ethan A Halm, Celette S Skinner, Joanne E Schottinger, Nirupa R Ghai, Andrea N Burnett-Hartman, Aruna Kamineni, Natalia Udaltsova, Douglas A Corley
IMPORTANCE: Postpolypectomy surveillance is a common colonoscopy indication in older adults; however, guidelines provide little direction on when to stop surveillance in this population. OBJECTIVE: To estimate surveillance colonoscopy yields in older adults. DESIGN, SETTING, AND PARTICIPANTS: This population-based cross-sectional study included individuals 70 to 85 years of age who received surveillance colonoscopy at a large, community-based US health care system between January 1, 2017, and December 31, 2019; had an adenoma detected 12 or more months previously; and had at least 1 year of health plan enrollment before surveillance...
April 1, 2024: JAMA Network Open
#10
JOURNAL ARTICLE
Ayse Bahar Ercan, Melyssa Aronson, Nicholas R Fernandez, Yuan Chang, Adrian Levine, Zhihui Amy Liu, Logine Negm, Melissa Edwards, Vanessa Bianchi, Lucie Stengs, Jiil Chung, Abeer Al-Battashi, Agnes Reschke, Alex Lion, Alia Ahmad, Alvaro Lassaletta, Alyssa T Reddy, Amir F Al-Darraji, Amish C Shah, An Van Damme, Anne Bendel, Aqeela Rashid, Ashley S Margol, Bethany L Kelly, Bojana Pencheva, Brandie Heald, Brianna Lemieux-Anglin, Bruce Crooks, Carl Koschmann, Catherine Gilpin, Christopher C Porter, David Gass, David Samuel, David S Ziegler, Deborah T Blumenthal, Dennis John Kuo, Dima Hamideh, Donald Basel, Dong-Anh Khuong-Quang, Duncan Stearns, Enrico Opocher, Fernando Carceller, Hagit Baris Feldman, Helen Toledano, Ira Winer, Isabelle Scheers, Ivana Fedorakova, Jack M Su, Jaime Vengoechea, Jaroslav Sterba, Jeffrey Knipstein, Jordan R Hansford, Julieta Rita Gonzales-Santos, Kanika Bhatia, Kevin J Bielamowicz, Khurram Minhas, Kim E Nichols, Kristina A Cole, Lynette Penney, Magnus Aasved Hjort, Magnus Sabel, Maria Joao Gil-da-Costa, Matthew J Murray, Matthew Miller, Maude L Blundell, Maura Massimino, Maysa Al-Hussaini, Mazin F Al-Jadiry, Melanie A Comito, Michael Osborn, Michael P Link, Michal Zapotocky, Mithra Ghalibafian, Najma Shaheen, Naureen Mushtaq, Nicolas Waespe, Nobuko Hijiya, Noemi Fuentes-Bolanos, Olfat Ahmad, Omar Chamdine, Paromita Roy, Pavel N Pichurin, Per Nyman, Rachel Pearlman, Rebecca C Auer, Reghu K Sukumaran, Rejin Kebudi, Rina Dvir, Robert Raphael, Ronit Elhasid, Rose B McGee, Rose Chami, Ryan Noss, Ryuma Tanaka, Salmo Raskin, Santanu Sen, Scott Lindhorst, Sebastien Perreault, Shani Caspi, Shazia Riaz, Shlomi Constantini, Sophie Albert, Stanley Chaleff, Stefan Bielack, Stefano Chiaravalli, Stuart Louis Cramer, Sumita Roy, Suzanne Cahn, Suzanne Penna, Syed Ahmer Hamid, Tariq Ghafoor, Uzma Imam, Valerie Larouche, Vanan Magimairajan Issai, William D Foulkes, Yi Yen Lee, Paul C Nathan, Yosef E Maruvka, Mary-Louise C Greer, Carol Durno, Adam Shlien, Birgit Ertl-Wagner, Anita Villani, David Malkin, Cynthia Hawkins, Eric Bouffet, Anirban Das, Uri Tabori
BACKGROUND: Constitutional mismatch repair deficiency (CMMRD) syndrome is a rare and aggressive cancer predisposition syndrome. Because a scarcity of data on this condition contributes to management challenges and poor outcomes, we aimed to describe the clinical spectrum, cancer biology, and impact of genetics on patient survival in CMMRD. METHODS: In this cohort study, we collected cross-sectional and longitudinal data on all patients with CMMRD, with no age limits, registered with the International Replication Repair Deficiency Consortium (IRRDC) across more than 50 countries...
March 26, 2024: Lancet Oncology
#11
JOURNAL ARTICLE
Juan A Perez-Bermejo, Oghene Efagene, William M Matern, Jeffrey K Holden, Shaheen Kabir, Glen M Chew, Gaia Andreoletti, Eniola Catton, Craig L Ennis, Angelica Garcia, Trevor L Gerstenberg, Kaisle A Hill, Aayami Jain, Kristina Krassovsky, Cassandra D Lalisan, Daniel Lord, B Joy Quejarro, Jade Sales-Lee, Meet Shah, Brian J Silva, Jason Skowronski, Yuri G Strukov, Joshua Thomas, Michael Veraz, Twaritha Vijay, Kirby A Wallace, Yue Yuan, Jane L Grogan, Beeke Wienert, Premanjali Lahiri, Sebastian Treusch, Daniel P Dever, Vanessa B Soros, James R Partridge, Kristen L Seim
Homology Directed Repair (HDR) enables precise genome editing, but the implementation of HDR-based therapies is hindered by limited efficiency in comparison to methods that exploit alternative DNA repair routes, such as Non-Homologous End Joining (NHEJ). In this study, we develop a functional, pooled screening platform to identify protein-based reagents that improve HDR in human hematopoietic stem and progenitor cells (HSPCs). We leverage this screening platform to explore sequence diversity at the binding interface of the NHEJ inhibitor i53 and its target, 53BP1, identifying optimized variants that enable new intermolecular bonds and robustly increase HDR...
March 23, 2024: Nature Communications
#12
JOURNAL ARTICLE
X Mi, A A Michailidis, S Shabani, K C Miao, P V Klimov, J Lloyd, E Rosenberg, R Acharya, I Aleiner, T I Andersen, M Ansmann, F Arute, K Arya, A Asfaw, J Atalaya, J C Bardin, A Bengtsson, G Bortoli, A Bourassa, J Bovaird, L Brill, M Broughton, B B Buckley, D A Buell, T Burger, B Burkett, N Bushnell, Z Chen, B Chiaro, D Chik, C Chou, J Cogan, R Collins, P Conner, W Courtney, A L Crook, B Curtin, A G Dau, D M Debroy, A Del Toro Barba, S Demura, A Di Paolo, I K Drozdov, A Dunsworth, C Erickson, L Faoro, E Farhi, R Fatemi, V S Ferreira, L F Burgos, E Forati, A G Fowler, B Foxen, É Genois, W Giang, C Gidney, D Gilboa, M Giustina, R Gosula, J A Gross, S Habegger, M C Hamilton, M Hansen, M P Harrigan, S D Harrington, P Heu, M R Hoffmann, S Hong, T Huang, A Huff, W J Huggins, L B Ioffe, S V Isakov, J Iveland, E Jeffrey, Z Jiang, C Jones, P Juhas, D Kafri, K Kechedzhi, T Khattar, M Khezri, M Kieferová, S Kim, A Kitaev, A R Klots, A N Korotkov, F Kostritsa, J M Kreikebaum, D Landhuis, P Laptev, K-M Lau, L Laws, J Lee, K W Lee, Y D Lensky, B J Lester, A T Lill, W Liu, A Locharla, F D Malone, O Martin, J R McClean, M McEwen, A Mieszala, S Montazeri, A Morvan, R Movassagh, W Mruczkiewicz, M Neeley, C Neill, A Nersisyan, M Newman, J H Ng, A Nguyen, M Nguyen, M Y Niu, T E O'Brien, A Opremcak, A Petukhov, R Potter, L P Pryadko, C Quintana, C Rocque, N C Rubin, N Saei, D Sank, K Sankaragomathi, K J Satzinger, H F Schurkus, C Schuster, M J Shearn, A Shorter, N Shutty, V Shvarts, J Skruzny, W C Smith, R Somma, G Sterling, D Strain, M Szalay, A Torres, G Vidal, B Villalonga, C V Heidweiller, T White, B W K Woo, C Xing, Z J Yao, P Yeh, J Yoo, G Young, A Zalcman, Y Zhang, N Zhu, N Zobrist, H Neven, R Babbush, D Bacon, S Boixo, J Hilton, E Lucero, A Megrant, J Kelly, Y Chen, P Roushan, V Smelyanskiy, D A Abanin
Engineered dissipative reservoirs have the potential to steer many-body quantum systems toward correlated steady states useful for quantum simulation of high-temperature superconductivity or quantum magnetism. Using up to 49 superconducting qubits, we prepared low-energy states of the transverse-field Ising model through coupling to dissipative auxiliary qubits. In one dimension, we observed long-range quantum correlations and a ground-state fidelity of 0.86 for 18 qubits at the critical point. In two dimensions, we found mutual information that extends beyond nearest neighbors...
March 22, 2024: Science
#13
JOURNAL ARTICLE
Kathryn P Goggin, Lu Lu, Danielle E Lee, Carrie R Howell, Deokumar Srivastava, Tara M Brinkman, Gregory T Armstrong, Nickhill Bhakta, Leslie L Robison, Mathew J Ehrhardt, Melissa M Hudson, Kevin R Krull, Ching-Hon Pui, Jeffrey Rubnitz, Kirsten K Ness, Joshua Wolf
IMPORTANCE: Children undergoing treatment for leukemia are at increased risk of severe sepsis, a dysregulated immune response to infection leading to acute organ dysfunction. As cancer survivors, they face a high burden of long-term adverse effects. The association between sepsis during anticancer therapy and long-term organ dysfunction in adult survivors of childhood cancer has not been examined. OBJECTIVE: To determine whether severe sepsis during therapy for leukemia in childhood is associated with subsequent chronic health conditions in adult survivors...
March 4, 2024: JAMA Network Open
#14
Pavithra Nagarajan, Thomas W Winkler, Amy R Bentley, Clint L Miller, Aldi T Kraja, Karen Schwander, Songmi Lee, Wenyi Wang, Michael R Brown, John L Morrison, Ayush Giri, Jeffrey R O'Connell, Traci M Bartz, Lisa de Las Fuentes, Valborg Gudmundsdottir, Xiuqing Guo, Sarah E Harris, Zhijie Huang, Mart Kals, Minjung Kho, Christophe Lefevre, Jian'an Luan, Leo-Pekka Lyytikäinen, Massimo Mangino, Yuri Milaneschi, Nicholette D Palmer, Varun Rao, Rainer Rauramaa, Botong Shen, Stefan Stadler, Quan Sun, Jingxian Tang, Sébastien Thériault, Adriaan van der Graaf, Peter J van der Most, Yujie Wang, Stefan Weiss, Kenneth E Westerman, Qian Yang, Tabara Yasuharu, Wei Zhao, Wanying Zhu, Drew Altschul, Md Abu Yusuf Ansari, Pramod Anugu, Anna D Argoty-Pantoja, Michael Arzt, Hugues Aschard, John R Attia, Lydia Bazzanno, Max A Breyer, Jennifer A Brody, Brian E Cade, Hung-Hsin Chen, Yii-Der Ida Chen, Zekai Chen, Paul S de Vries, Latchezar M Dimitrov, Anh Do, Jiawen Du, Charles T Dupont, Todd L Edwards, Michele K Evans, Tariq Faquih, Stephan B Felix, Susan P Fisher-Hoch, James S Floyd, Mariaelisa Graff, Charles Gu, Dongfeng Gu, Kristen G Hairston, Anthony J Hanley, Iris M Heid, Sami Heikkinen, Heather M Highland, Michelle M Hood, Mika Kähönen, Carrie A Karvonen-Gutierrez, Takahisa Kawaguchi, Setoh Kazuya, Tanika N Kelly, Pirjo Komulainen, Daniel Levy, Henry J Lin, Peter Y Liu, Pedro Marques-Vidal, Joseph B McCormick, Hao Mei, James B Meigs, Cristina Menni, Kisung Nam, Ilja M Nolte, Natasha L Pacheco, Lauren E Petty, Hannah G Polikowsky, Michael A Province, Bruce M Psaty, Laura M Raffield, Olli T Raitakari, Stephen S Rich, Renata L Riha, Lorenz Risch, Martin Risch, Edward A Ruiz-Narvaez, Rodney J Scott, Colleen M Sitlani, Jennifer A Smith, Tamar Sofer, Maris Teder-Laving, Uwe Völker, Peter Vollenweider, Guanchao Wang, Ko Willems van Dijk, Otis D Wilson, Rui Xia, Jie Yao, Kristin L Young, Ruiyuan Zhang, Xiaofeng Zhu, Jennifer E Below, Carsten A Böger, David Conen, Simon R Cox, Marcus Dörr, Mary F Feitosa, Ervin R Fox, Nora Franceschini, Sina A Gharib, Vilmundur Gudnason, Sioban D Harlow, Jiang He, Elizabeth G Holliday, Zoltan Kutalik, Timo A Lakka, Deborah A Lawlor, Seunggeun Lee, Terho Lehtimäki, Changwei Li, Ching-Ti Liu, Reedik Mägi, Fumihiko Matsuda, Alanna C Morrison, Brenda Wjh Penninx, Patricia A Peyser, Jerome I Rotter, Harold Snieder, Tim D Spector, Lynne E Wagenknecht, Nicholas J Wareham, Alan B Zonderman, Kari E North, Myriam Fornage, Adriana M Hung, Alisa K Manning, James Gauderman, Han Chen, Patricia B Munroe, Dabeeru C Rao, Diana van Heemst, Susan Redline, Raymond Noordam, Heming Wang
Although both short and long sleep duration are associated with elevated hypertension risk, our understanding of their interplay with biological pathways governing blood pressure remains limited. To address this, we carried out genome-wide cross-population gene-by-short-sleep and long-sleep duration interaction analyses for three blood pressure traits (systolic, diastolic, and pulse pressure) in 811,405 individuals from diverse population groups. We discover 22 novel gene-sleep duration interaction loci for blood pressure, mapped to genes involved in neurological, thyroidal, bone metabolism, and hematopoietic pathways...
March 8, 2024: medRxiv
#15
JOURNAL ARTICLE
Jeremy C Heard, Teeto Ezeonu, Yunsoo Lee, Rajkishen Narayanan, Tariq Issa, Cordero McCall, Yoni Dulitzki, Dylan Resnick, Jeffrey Zucker, Alexander Shaer, Mark Kurd, Alan S Hilibrand, Alexander R Vaccaro, Christopher K Kepler, Gregory D Schroeder, Jose A Canseco
STUDY DESIGN: Retrospective cohort study. OBJECTIVE: The purpose of this study is to investigate whether weekday lumbar spine fusion surgery has an impact on surgical and inpatient physical therapy (PT) outcomes. SUMMARY OF BACKGROUND DATA: Timing of surgery has been implicated as a factor that may impact outcomes after spine surgery. Previous literature suggests that there may be an adverse effect to having surgery on the weekend. METHODS: All patients ≥18 years who underwent primary lumbar spinal fusion from 2014 to 2020 were retrospectively identified...
March 12, 2024: Clinical Spine Surgery
#16
JOURNAL ARTICLE
Marilyn S Lee, Jennifer A Lee, John R Biondo, Jeffrey E Lux, Rebecca M Raig, Pierce N Berger, Casey B Bernhards, Danielle L Kuhn, Maneesh K Gupta, Matthew W Lux
While synthetic biology has advanced complex capabilities such as sensing and molecular synthesis in aqueous solutions, important applications may also be pursued for biological systems in solid materials. Harsh processing conditions used to produce many synthetic materials such as plastics make the incorporation of biological functionality challenging. One technology that shows promise in circumventing these issues is cell-free protein synthesis (CFPS), where core cellular functionality is reconstituted outside the cell...
March 11, 2024: ACS Synthetic Biology
#17
JOURNAL ARTICLE
Justin Leung, Dimitrios Pollalis, Gopa K G Nair, Jeffrey K Bailey, Britney O Pennington, Amir I Khan, Kaitlin R Kelly, Ashley K Yeh, Kartik S Sundaram, Dennis O Clegg, Chen-Ching Peng, Liya Xu, Sun Young Lee
PURPOSE: Isolating extracellular vesicles (EVs) with high yield, replicable purity, and characterization remains a bottleneck in the development of EV therapeutics. To address these challenges, the current study aims to establish the necessary framework for preclinical and clinical studies in the development of stem cell-derived intraocular EV therapeutics. METHODS: Small EVs (sEVs) were separated from the conditioned cell culture medium (CCM) of the human embryogenic stem cell-derived fully polarized retinal pigment epithelium (hESC-RPE-sEV) by a commercially available microfluidic tangential flow filtration (TFF) device ExoDisc (ED) or differential ultracentrifugation (dUC)...
March 5, 2024: Investigative Ophthalmology & Visual Science
#18
JOURNAL ARTICLE
Alaina M Bever, Dong Hang, Dong Hoon Lee, Fred K Tabung, Tomotaka Ugai, Shuji Ogino, Jeffrey A Meyerhardt, Andrew T Chan, A Heather Eliassen, Liming Liang, Meir J Stampfer, Mingyang Song
BACKGROUND: Inflammation and metabolic dysregulation are associated with increased risk of colorectal cancer (CRC); the underlying mechanisms are not fully understood. We characterized metabolomic signatures of inflammation and metabolic dysregulation and evaluated the association of the signatures and individual metabolites with CRC risk. METHODS: Among 684 incident CRC cases and 684 age-matched controls in the Nurses' Health Study (n = 818 women) and Health Professionals Follow-up Study (n = 550 men), we applied reduced rank and elastic net regression to 277 metabolites for markers of inflammation (CRP, IL6, TNFRSF1B, and GDF15) or metabolic dysregulation (body mass index, waist circumference, C-peptide, and adiponectin) to derive metabolomic signatures...
March 1, 2024: Journal of the National Cancer Institute
#19
JOURNAL ARTICLE
Sutton B Richmond, Rachael D Seidler, Jeffrey J Iliff, Daniel L Schwartz, Madison Luther, Lisa C Silbert, Scott J Wood, Jacob J Bloomberg, Edwin Mulder, Jessica K Lee, Alberto De Luca, Juan Piantino
During long-duration spaceflight, astronauts experience headward fluid shifts and expansion of the cerebral perivascular spaces (PVS). A major limitation to our understanding of the changes in brain structure and physiology induced by spaceflight stems from the logistical difficulties of studying astronauts. The current study aimed to determine whether PVS changes also occur on Earth with the spaceflight analog head-down tilt bed rest (HDBR). We examined how the number and morphology of magnetic resonance imaging-visible PVS (MV-PVS) are affected by HDBR with and without elevated carbon dioxide (CO2 )...
March 1, 2024: NPJ Microgravity
#20
JOURNAL ARTICLE
Douglas A Mata, Jessica K Lee, Vignesh Shanmugam, Chelsea B Marcus, Alexa B Schrock, Erik A Williams, Lauren L Ritterhouse, Richard A Hickman, Tyler Janovitz, Nimesh R Patel, Benjamin R Kroger, Jeffrey S Ross, Kamran M Mirza, Geoffrey R Oxnard, Jo-Anne Vergilio, Julia A Elvin, Jamal K Benhamida, Brennan Decker, Mina L Xu
AIMS: Liquid biopsy (LBx)-based next-generation sequencing (NGS) of circulating tumour DNA (ctDNA) can facilitate molecular profiling of haematopoietic neoplasms (HNs), particularly when tissue-based NGS is infeasible. METHODS AND RESULTS: We studied HN LBx samples tested with FoundationOne Liquid CDx, FoundationOne Liquid, or FoundationACT between July 2016 and March 2022. We identified 271 samples: 89 non-Hodgkin lymphoma (NHL), 43 plasma-cell neoplasm (PCN), 41 histiocytoses, 27 myelodysplastic syndrome (MDS), 25 diffuse large B-cell lymphoma (DLBCL), 22 myeloproliferative neoplasm (MPN), 14 Hodgkin lymphoma (HL), and 10 acute myeloid leukaemia (AML)...
February 29, 2024: Histopathology
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