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https://www.readbyqxmd.com/read/27890647/reducing-preterm-birth-by-a-state-wide-multifaceted-program-an-implementation-study
#1
John P Newnham, Scott W White, Suzanne Meharry, Han-Shin Lee, Michelle K Pedretti, Catherine A Arrese, Jeffrey A Keelan, Matthew W Kemp, Jan E Dickinson, Dorota A Doherty
BACKGROUND: A comprehensive preterm birth prevention program was introduced in the state of Western Australia encompassing new clinical guidelines, an outreach program for health care practitioners, a public health program for women and their families based on print and social media, and a new clinic at the state's sole tertiary level perinatal center for referral of those pregnant women at highest risk. The initiative had the single aim of safely lowering the rate of preterm birth. OBJECTIVE: The objective of the study was to evaluate the outcomes of the initiative on the rates of preterm birth both state-wide and in the single tertiary level perinatal referral center...
November 25, 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27870408/sex-specific-effects-of-the-huntington-gene-on-normal-neurodevelopment
#2
Jessica K Lee, Yue Ding, Amy L Conrad, Elena Cattaneo, Eric Epping, Kathy Mathews, Pedro Gonzalez-Alegre, Larry Cahill, Vincent Magnotta, Bradley L Schlaggar, Joel S Perlmutter, Regina E Y Kim, Jeffrey D Dawson, Peg Nopoulos
Huntington disease is a neurodegenerative disorder caused by a gene (HTT) with a unique feature of trinucleotide repeats ranging from 10 to 35 in healthy people; when expanded beyond 39 repeats, Huntington disease develops. Animal models demonstrate that HTT is vital to brain development; however, this has not been studied in humans. Moreover, evidence suggests that triplet repeat genes may have been vital in evolution of the human brain. Here we evaluate brain structure using magnetic resonance imaging and brain function using cognitive tests in a sample of school-aged children ages 6 to 18 years old...
January 2, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27843641/esmo-asco-recommendations-for-a-global-curriculum-in-medical-oncology-edition-2016
#3
REVIEW
Christian Dittrich, Michael Kosty, Svetlana Jezdic, Doug Pyle, Rossana Berardi, Jonas Bergh, Nagi El-Saghir, Jean-Pierre Lotz, Pia Österlund, Nicholas Pavlidis, Gunta Purkalne, Ahmad Awada, Susana Banerjee, Smita Bhatia, Jan Bogaerts, Jan Buckner, Fatima Cardoso, Paolo Casali, Edward Chu, Julia Lee Close, Bertrand Coiffier, Roisin Connolly, Sarah Coupland, Luigi De Petris, Maria De Santis, Elisabeth G E de Vries, Don S Dizon, Jennifer Duff, Linda R Duska, Alexandru Eniu, Marc Ernstoff, Enriqueta Felip, Martin F Fey, Jill Gilbert, Nicolas Girard, Andor W J M Glaudemans, Priya K Gopalan, Axel Grothey, Stephen M Hahn, Diana Hanna, Christian Herold, Jørn Herrstedt, Krisztian Homicsko, Dennie V Jones, Lorenz Jost, Ulrich Keilholz, Saad Khan, Alexander Kiss, Claus-Henning Köhne, Rainer Kunstfeld, Heinz-Josef Lenz, Stuart Lichtman, Lisa Licitra, Thomas Lion, Saskia Litière, Lifang Liu, Patrick J Loehrer, Merry Jennifer Markham, Ben Markman, Marius Mayerhoefer, Johannes G Meran, Olivier Michielin, Elizabeth Charlotte Moser, Giannis Mountzios, Timothy Moynihan, Torsten Nielsen, Yuichiro Ohe, Kjell Öberg, Antonio Palumbo, Fedro Alessandro Peccatori, Michael Pfeilstöcker, Chandrajit Raut, Scot C Remick, Mark Robson, Piotr Rutkowski, Roberto Salgado, Lidia Schapira, Eva Schernhammer, Martin Schlumberger, Hans-Joachim Schmoll, Lowell Schnipper, Cristiana Sessa, Charles L Shapiro, Julie Steele, Cora N Sternberg, Friedrich Stiefel, Florian Strasser, Roger Stupp, Richard Sullivan, Josep Tabernero, Luzia Travado, Marcel Verheij, Emile Voest, Everett Vokes, Jamie Von Roenn, Jeffrey S Weber, Hans Wildiers, Yosef Yarden
The European Society for Medical Oncology (ESMO) and the American Society of Clinical Oncology (ASCO) are publishing a new edition of the ESMO/ASCO Global Curriculum (GC) thanks to contribution of 64 ESMO-appointed and 32 ASCO-appointed authors. First published in 2004 and updated in 2010, the GC edition 2016 answers to the need for updated recommendations for the training of physicians in medical oncology by defining the standard to be fulfilled to qualify as medical oncologists. At times of internationalisation of healthcare and increased mobility of patients and physicians, the GC aims to provide state-of-the-art cancer care to all patients wherever they live...
2016: ESMO Open
https://www.readbyqxmd.com/read/27794500/local-control-and-toxicity-of-a-simultaneous-integrated-boost-for-dose-escalation-in-locally-advanced-esophageal-cancer-interim-results-from-a-prospective-phase-i-ii-trial
#4
James W Welsh, Steven N Seyedin, Pamela K Allen, Wayne L Hofstetter, Jaffer A Ajani, Joe Y Chang, Daniel R Gomez, Arya Amini, Stephen G Swisher, Mariela A Blum, Ahmed I Younes, Quynh-Nhu Nguyen, Bruce D Minsky, Jeremy J Erasmus, Jeffrey H Lee, Manoop Bhutani, Ritsuko U Komaki
INTRODUCTION: Approximately 50% of recurrences after standard-dose chemoradiation for locally advanced esophageal cancer occur within the gross tumor volume (GTV). In this prospective phase I/II clinical trial, we explored use of a simultaneous integrated boost (SIB) dose to the GTV. METHODS: Forty-four patients with unresectable esophageal cancer received chemoradiation with an SIB of 58.8-63 Gy to the GTV and 50.4 Gy to the PTV, all in 28 fractions, with 5 weeks of concurrent docetaxel and fluorouracil or capecitabine...
October 26, 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27793025/hedgehog-pathway-dysregulation-contributes-to-the-pathogenesis-of-human-gastrointestinal-stromal-tumors-via-gli-mediated-activation-of-kit-expression
#5
Chih-Min Tang, Tracy E Lee, Sabriya A Syed, Adam M Burgoyne, Stephanie Y Leonard, Fei Gao, Jonathan C Chan, Eileen Shi, Juliann Chmielecki, Deborah Morosini, Kai Wang, Jeffrey S Ross, Michael L Kendrick, Michael R Bardsley, Martina De Siena, Junhao Mao, Olivier Harismendy, Tamas Ordog, Jason K Sicklick
Gastrointestinal stromal tumors (GIST) arise within the interstitial cell of Cajal (ICC) lineage due to activating KIT/PDGFRA mutations. Both ICC and GIST possess primary cilia (PC), which coordinate PDGFRA and Hedgehog signaling, regulators of gastrointestinal mesenchymal development. Therefore, we hypothesized that Hedgehog signaling may be altered in human GIST and controls KIT expression. Quantitative RT-PCR, microarrays, and next generation sequencing were used to describe Hedgehog/PC-related genes in purified human ICC and GIST...
October 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27792790/phactr1-is-a-genetic-susceptibility-locus-for-fibromuscular-dysplasia-supporting-its-complex-genetic-pattern-of-inheritance
#6
Soto Romuald Kiando, Nathan R Tucker, Luis-Jaime Castro-Vega, Alexander Katz, Valentina D'Escamard, Cyrielle Tréard, Daniel Fraher, Juliette Albuisson, Daniella Kadian-Dodov, Zi Ye, Erin Austin, Min-Lee Yang, Kristina Hunker, Cristina Barlassina, Daniele Cusi, Pilar Galan, Jean-Philippe Empana, Xavier Jouven, Anne-Paule Gimenez-Roqueplo, Patrick Bruneval, Esther Soo Hyun Kim, Jeffrey W Olin, Heather L Gornik, Michel Azizi, Pierre-François Plouin, Patrick T Ellinor, Iftikhar J Kullo, David J Milan, Santhi K Ganesh, Pierre Boutouyrie, Jason C Kovacic, Xavier Jeunemaitre, Nabila Bouatia-Naji
Fibromuscular dysplasia (FMD) is a nonatherosclerotic vascular disease leading to stenosis, dissection and aneurysm affecting mainly the renal and cerebrovascular arteries. FMD is often an underdiagnosed cause of hypertension and stroke, has higher prevalence in females (~80%) but its pathophysiology is unclear. We analyzed ~26K common variants (MAF>0.05) generated by exome-chip arrays in 249 FMD patients and 689 controls. We replicated 13 loci (P<10-4) in 402 cases and 2,537 controls and confirmed an association between FMD and a variant in the phosphatase and actin regulator 1 gene (PHACTR1)...
October 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27788309/the-role-of-rare-protein-coding-variants-to-anti-tnf-treatment-response-in-rheumatoid-arthritis
#7
Jing Cui, Dorothee Diogo, Eli A Stahl, Helena Canhao, Xavier Mariette, Jeffrey D Greenberg, Yukinori Okada, Dimitrios A Pappas, Robert S Fulton, Paul P Tak, Michael T Nurmohamed, Annette Lee, David E Larson, Fina Kurreeman, Tracie L Deluca, Michelle O'Laughlin, Catrina C Fronick, Lucinda L Fulton, Elaine R Mardis, Irene E van der Horst-Bruinsma, Gert-Jan Wolbink, Peter K Gregersen, Joel M Kremer, J Bart A Crusius, Niek de Vries, Tom W J Huizinga, João Eurico Fonseca, Corinne Miceli-Richard, Elizabeth W Karlson, Marieke Jh Coenen, Anne Barton, Robert M Plenge, Soumya Raychaudhuri
Objective Many rheumatoid arthritis (RA) patients have their disease controlled with anti-tumor necrosis factor alpha (anti-TNF) biologic therapies. However, a significant number of RA patients fail to respond to anti-TNF therapy. Here, we hypothesized that rare and low-frequency variants might influence anti-TNF treatment response. Methods We sequenced the coding region of 750 genes in 1,094 RA patients of European ancestry treated with anti-TNF medications. After quality control, we included 690 genes in the analysis...
October 27, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27782940/effects-of-obesity-and-leptin-deficiency-on-morphine-pharmacokinetics-in-a-mouse-model
#8
Nicholas M Dalesio, Craig W Hendrix, Douglas Hale McMichael, Carol B Thompson, Carlton K K Lee, Huy Pho, Rafael S Arias, Rachael Rzasa Lynn, Jeffrey Galinkin, Myron Yaster, Robert H Brown, Alan R Schwartz
BACKGROUND: Obesity causes multiorgan dysfunction, specifically metabolic abnormalities in the liver. Obese patients are opioid-sensitive and have high rates of respiratory complications after surgery. Obesity also has been shown to cause resistance to leptin, an adipose-derived hormone that is key in regulating hunger, metabolism, and respiratory stimulation. We hypothesized that obesity and leptin deficiency impair opioid pharmacokinetics (PK) independently of one another. METHODS: Morphine PK were characterized in C57BL/6J wild-type (WT), diet-induced obese (DIO), and leptin-deficient (ob/ob) mice, and in ob/ob mice given leptin-replacement (LR) therapy...
December 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27773052/identification-of-a-pathogenic-variant-in-trex1-in-early-onset-cerebral-sle-by-whole-exome-sequencing
#9
Julia I Ellyard, Rebekka Jerjen, Jaime L Martin, Adrian Lee, Matthew A Field, Simon H Jiang, Jean Cappello, Svenja K Naumann, T Daniel Andrews, Hamish S Scott, Marco G Casarotto, Christopher C Goodnow, Jeffrey Chaitow, Virginia Pascual, Paul Hertzog, Stephen I Alexander, Matthew C Cook, Carola G Vinuesa
No abstract text is available yet for this article.
February 2016: Pathology
https://www.readbyqxmd.com/read/27769517/recommendations-on-fecal-immunochemical-testing-to-screen-for-colorectal-neoplasia-a-consensus-statement-by-the-us-multi-society-task-force-on-colorectal-cancer
#10
Douglas J Robertson, Jeffrey K Lee, C Richard Boland, Jason A Dominitz, Francis M Giardiello, David A Johnson, Tonya Kaltenbach, David Lieberman, Theodore R Levin, Douglas K Rex
The use of the fecal occult blood test (FOBT) for colorectal cancer (CRC) screening is supported by randomized trials demonstrating effectiveness in cancer prevention and widely recommended by guidelines for this purpose. The fecal immunochemical test (FIT), as a direct measure of human hemoglobin in stool has a number of advantages relative to conventional FOBT and is increasingly used relative to that test. This review summarizes current evidence for FIT in colorectal neoplasia detection and the comparative effectiveness of FIT relative to other commonly used CRC screening modalities...
October 18, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27769516/recommendations-on-fecal-immunochemical-testing-to-screen-for%C3%A2-colorectal-neoplasia-a-consensus-statement-by-the-us-multi-society-task-force-on-colorectal-cancer
#11
Douglas J Robertson, Jeffrey K Lee, C Richard Boland, Jason A Dominitz, Francis M Giardiello, David A Johnson, Tonya Kaltenbach, David Lieberman, Theodore R Levin, Douglas K Rex
No abstract text is available yet for this article.
October 4, 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27768789/impact-of-genetic-loci-identified-in-genome-wide-association-studies-on-diabetic-retinopathy-in-chinese-patients-with-type-2-diabetes
#12
Chloe Y Y Cheung, Elaine Y L Hui, Chi-Ho Lee, Kelvin H M Kwok, Rita A Gangwani, Kenneth K W Li, Jeffrey C W Chan, Yu-Cho Woo, Wing-Sun Chow, Michele M A Yuen, Rachel L C Wong, Carol H Y Fong, Aimin Xu, David S H Wong, Pak-Chung Sham, Karen S L Lam
Purpose: Diabetic retinopathy (DR) is a common microvascular complication of type 2 diabetes (T2DM). Genome-wide association studies (GWAS) had identified novel DR-susceptibility genetic variants in various populations. We examined the associations of these DR-associated single nucleotide polymorphisms (SNPs) with severe DR in a Chinese T2DM cohort. Methods: Cross-sectional case-control studies on sight-threatening DR (STDR) and proliferative DR (PDR) were performed...
October 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27753435/recommendations-on-fecal-immunochemical-testing-to-screen-for-colorectal-neoplasia-a-consensus-statement-by-the-us-multi-society-task-force-on-colorectal-cancer
#13
Douglas J Robertson, Jeffrey K Lee, C Richard Boland, Jason A Dominitz, Francis M Giardiello, David A Johnson, Tonya Kaltenbach, David Lieberman, Theodore R Levin, Douglas K Rex
The use of the fecal occult blood test (FOBT) for colorectal cancer (CRC) screening is supported by randomized trials demonstrating effectiveness in cancer prevention and widely recommended by guidelines for this purpose. The fecal immunochemical test (FIT), as a direct measure of human hemoglobin in stool has a number of advantages relative to conventional FOBT and is increasingly used relative to that test. This review summarizes current evidence for FIT in colorectal neoplasia detection and the comparative effectiveness of FIT relative to other commonly used CRC screening modalities...
October 18, 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27753113/the-qt-interval-as-a-noninvasive-marker-of-atrial-refractoriness
#14
Kaylin T Nguyen, Rachel A Gladstone, Jonathan W Dukes, Babak Nazer, Eric Vittinghoff, Nitish Badhwar, Vasanth Vedantham, Edward P Gerstenfeld, Byron K Lee, Randall J Lee, Zian H Tseng, Jeffrey E Olgin, Melvin M Scheinman, Gregory M Marcus
BACKGROUND: Atrial refractoriness may be an important determinant of atrial fibrillation (AF) risk, but its measurement is not clinically accessible. Because the QT interval predicts incident AF and the atrium and ventricle share repolarizing ion currents, we investigated the association between an individual's QT interval and atrial effective refractory period (AERP). METHODS: In paroxysmal AF patients presenting for catheter ablation, the QT interval was measured from the surface 12-lead electrocardiogram...
October 18, 2016: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/27743204/the-cranial-sagittal-vertical-axis-crsva-is-a-better-radiographic-measure-to-predict-clinical-outcomes-in-adult-spinal-deformity-surgery-than-the-c7-sva-a-monocentric-study
#15
Yong-Chan Kim, Lawrence G Lenke, Seon-Jong Lee, Jeffrey L Gum, Sirichai Wilartratsami, Kathy M Blanke
PURPOSE: Our study aimed to confirm the correlation between the Cranial Sagittal Vertical Axis (CrSVA) and patient-reported outcomes and to compare clinical correlation between CrSVA and C7 SVA in adult spinal deformity (ASD) patients. METHODS: 108 consecutive ASD patients were evaluated using the EOS(®) 2D/3D radio-imaging device. A vertical plumb line from the cranial center was utilized to measure the distance to the posterior corner of S1 (CrSVA-S), and to the centers of the hip (CrSVA-H), the knee (CrSVA-K), and ankle (CrSVA-A), as well as measuring the standard C7 SVA...
October 14, 2016: European Spine Journal
https://www.readbyqxmd.com/read/27742123/the-relationship-of-nosocomial-infection-reduction-to-changes-in-neonatal-intensive-care-unit-rates-of-bronchopulmonary-dysplasia
#16
Wannasiri Lapcharoensap, Peiyi Kan, Richard J Powers, Gary M Shaw, David K Stevenson, Jeffrey B Gould, David D Wirtschafter, Henry C Lee
OBJECTIVE: To examine whether recent reductions in rates of nosocomial infection have contributed to changes in rates of bronchopulmonary dysplasia (BPD) in a population-based cohort. STUDY DESIGN: This was a retrospective, population-based cohort study that used the California Perinatal Quality Care Collaborative database from 2006 to 2013. Eligible infants included those less than 30 weeks' gestational age and less than 1500 g who survived to 3 days of life. Primary variables of interest were rates of nosocomial infections and BPD...
October 11, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27730401/externalized-stents-for-pancreatoduodenectomy-provide-value-only-in-high-risk-scenarios
#17
Matthew T McMillan, Brett L Ecker, Stephen W Behrman, Mark P Callery, John D Christein, Jeffrey A Drebin, Douglas L Fraker, Tara S Kent, Major K Lee, Robert E Roses, Michael H Sprys, Charles M Vollmer
BACKGROUND: Evidence suggests externalized trans-anastomotic stents may be beneficial as a fistula mitigation strategy for pancreatoduodenectomy (PD); however, previous studies have not been rigorously risk-adjusted. METHODS: From 2001 to 2015, PDs were performed at three institutions, with externalized stents placed at the surgeon's discretion. The Fistula Risk Score (FRS) and the Modified Accordion Severity Grading System were used to analyze occurrence and severity of clinically relevant postoperative pancreatic fistula (CR-POPF) across various risk scenarios...
October 11, 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/27725679/imaging-biomarker-roadmap-for-cancer-studies
#18
James P B O'Connor, Eric O Aboagye, Judith E Adams, Hugo J W L Aerts, Sally F Barrington, Ambros J Beer, Ronald Boellaard, Sarah E Bohndiek, Michael Brady, Gina Brown, David L Buckley, Thomas L Chenevert, Laurence P Clarke, Sandra Collette, Gary J Cook, Nandita M deSouza, John C Dickson, Caroline Dive, Jeffrey L Evelhoch, Corinne Faivre-Finn, Ferdia A Gallagher, Fiona J Gilbert, Robert J Gillies, Vicky Goh, John R Griffiths, Ashley M Groves, Steve Halligan, Adrian L Harris, David J Hawkes, Otto S Hoekstra, Erich P Huang, Brian F Hutton, Edward F Jackson, Gordon C Jayson, Andrew Jones, Dow-Mu Koh, Denis Lacombe, Philippe Lambin, Nathalie Lassau, Martin O Leach, Ting-Yim Lee, Edward L Leen, Jason S Lewis, Yan Liu, Mark F Lythgoe, Prakash Manoharan, Ross J Maxwell, Kenneth A Miles, Bruno Morgan, Steve Morris, Tony Ng, Anwar R Padhani, Geoff J M Parker, Mike Partridge, Arvind P Pathak, Andrew C Peet, Shonit Punwani, Andrew R Reynolds, Simon P Robinson, Lalitha K Shankar, Ricky A Sharma, Dmitry Soloviev, Sigrid Stroobants, Daniel C Sullivan, Stuart A Taylor, Paul S Tofts, Gillian M Tozer, Marcel van Herk, Simon Walker-Samuel, James Wason, Kaye J Williams, Paul Workman, Thomas E Yankeelov, Kevin M Brindle, Lisa M McShane, Alan Jackson, John C Waterton
Imaging biomarkers (IBs) are integral to the routine management of patients with cancer. IBs used daily in oncology include clinical TNM stage, objective response and left ventricular ejection fraction. Other CT, MRI, PET and ultrasonography biomarkers are used extensively in cancer research and drug development. New IBs need to be established either as useful tools for testing research hypotheses in clinical trials and research studies, or as clinical decision-making tools for use in healthcare, by crossing 'translational gaps' through validation and qualification...
October 11, 2016: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/27693681/do-no-harm-except-to-ourselves-a-survey-of-symptoms-and-injuries-in-oncologic-surgeons-and-pilot-study-of-an-intraoperative-ergonomic-intervention
#19
Rachel K Voss, Yi-Ju Chiang, Kate D Cromwell, Diana L Urbauer, Jeffrey E Lee, Janice N Cormier, Chee-Chee H Stucky
BACKGROUND: Occupational symptoms and injuries incurred over a surgical career are underreported yet impact daily surgical practice. We assessed the frequency, consequences, and risk factors for occupational injury in oncologic surgeons and evaluated the feasibility of intraoperative foot mat use to mitigate occupational symptoms. STUDY DESIGN: Oncologic surgeons completed a survey of demographic information and occupational symptoms and injuries. Multivariate logistic regression was used to identify factors associated with occupational symptoms and injuries...
September 29, 2016: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/27693347/genome-wide-association-study-identifies-african-specific-susceptibility-loci-in-african-americans-with-inflammatory-bowel-disease
#20
Steven R Brant, David T Okou, Claire L Simpson, David J Cutler, Talin Haritunians, Jonathan P Bradfield, Pankaj Chopra, Jarod Prince, Ferdouse Begum, Archana Kumar, Chengrui Huang, Suresh Venkateswaran, Lisa W Datta, Zhi Wei, Kelly Thomas, Lisa J Herrinton, Jan-Micheal A Klapproth, Antonio J Quiros, Jenifer Seminerio, Zhenqiu Liu, Jonathan S Alexander, Robert N Baldassano, Sharon Dudley-Brown, Raymond K Cross, Themistocles Dassopoulos, Lee A Denson, Tanvi A Dhere, Gerald W Dryden, John S Hanson, Jason K Hou, Sunny Z Hussain, Jeffrey S Hyams, Kim L Isaacs, Howard Kader, Michael D Kappelman, Jeffry Katz, Richard Kellermayer, Barbara S Kirschner, John F Kuemmerle, John H Kwon, Mark Lazarev, Ellen Li, David Mack, Peter Mannon, Dedrick E Moulton, Rodney D Newberry, Bankole O Osuntokun, Ashish S Patel, Shehzad A Saeed, Stephan R Targan, John F Valentine, Ming-Hsi Wang, Martin Zonca, John D Rioux, Richard H Duerr, Mark S Silverberg, Judy H Cho, Hakon Hakonarson, Michael E Zwick, Dermot P B McGovern, Subra Kugathasan
BACKGROUND & AIMS: The inflammatory bowel diseases (IBD) ulcerative colitis (UC) and Crohn's disease (CD) cause significant morbidity and are increasing in prevalence among all populations, including African Americans. More than 200 susceptibility loci have been identified in populations of predominantly European ancestry, but few loci have been associated with IBD in other ethnicities. METHODS: We performed 2 high-density, genome-wide scans comprising 2345 cases of African Americans with IBD (1646 with CD, 583 with UC, and 116 inflammatory bowel disease unclassified) and 5002 individuals without IBD (controls, identified from the Health Retirement Study and Kaiser Permanente database)...
September 28, 2016: Gastroenterology
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