Angelica A Gallardo, Mikaela Rose Gutierrez, Lyka Alexandrea J Gomez, Patricia Arielle O Delos Reyes, Sophia Allison A Dones, Maria Mikaela U Dumbrique, Heather Eena Lim, Maria Isabel H Liquido, Mary Margaret L Macawile, Ella Denese Anne B Maglaqui, Angelica Mae G Manalo, Mark Kevin P Devanadera, Alexis M Labrador
OBJECTIVE: The purpose of this study is to comparatively analyze the anticancer properties of Tetrahydrocannabinol (THC), Cannabidiol (CBD), and Tetrahydrocannabivarin (THCV) using In silico tools. METHODS: Using SwissADME and pkCSM, the physicochemical and pharmacokinetics properties of the cannabinoids were evaluated. Protox-II was utilized for the assessment of their cytotoxicity. The chemical-biological interactions of the cannabinoids were also predicted using the Way2Drug Predictive Server which comprises Acute Rat Toxicity, Adver-Pred, CLC-Pred, and Pass Target Prediction...
March 1, 2024: Asian Pacific Journal of Cancer Prevention: APJCP