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JOURNAL ARTICLE
Clara Podmore, Kevin Selby, Christopher D Jensen, Wei K Zhao, Noel S Weiss, Theodore R Levin, Joanne Schottinger, Chyke A Doubeni, Douglas A Corley
IMPORTANCE: Organized screening outreach can reduce differences in colorectal cancer (CRC) incidence and mortality between demographic subgroups. Outcomes associated with additional outreach, beyond universal outreach, are not well known. OBJECTIVE: To compare CRC screening completion by race and ethnicity, age, and sex after universal automated outreach and additional personalized outreach. DESIGN, SETTING, AND PARTICIPANTS: This observational cohort study included screening-eligible individuals aged 50 to 75 years assessed during 2019 in a community-based organized CRC screening program within the Kaiser Permanente Northern California (KPNC) integrated health care delivery setting...
April 1, 2024: JAMA Network Open
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JOURNAL ARTICLE
Jeffrey K Lee, Abhik Roy, Christopher D Jensen, Jennifer T Chan, Wei K Zhao, Theodore R Levin, Jessica Chubak, Ethan A Halm, Celette S Skinner, Joanne E Schottinger, Nirupa R Ghai, Andrea N Burnett-Hartman, Aruna Kamineni, Natalia Udaltsova, Douglas A Corley
IMPORTANCE: Postpolypectomy surveillance is a common colonoscopy indication in older adults; however, guidelines provide little direction on when to stop surveillance in this population. OBJECTIVE: To estimate surveillance colonoscopy yields in older adults. DESIGN, SETTING, AND PARTICIPANTS: This population-based cross-sectional study included individuals 70 to 85 years of age who received surveillance colonoscopy at a large, community-based US health care system between January 1, 2017, and December 31, 2019; had an adenoma detected 12 or more months previously; and had at least 1 year of health plan enrollment before surveillance...
April 1, 2024: JAMA Network Open
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JOURNAL ARTICLE
Joanna E Moodie, Sarah E Harris, Mathew A Harris, Colin R Buchanan, Gail Davies, Adele Taylor, Paul Redmond, David C M Liewald, Maria Del C Valdés Hernández, Susan Shenkin, Tom C Russ, Susana Muñoz Maniega, Michelle Luciano, Janie Corley, Aleks Stolicyn, Xueyi Shen, Douglas Steele, Gordon Waiter, Anca-Larisa Sandu, Mark E Bastin, Joanna M Wardlaw, Andrew McIntosh, Heather Whalley, Elliot M Tucker-Drob, Ian J Deary, Simon R Cox
Gene expression varies across the brain. This spatial patterning denotes specialised support for particular brain functions. However, the way that a given gene's expression fluctuates across the brain may be governed by general rules. Quantifying patterns of spatial covariation across genes would offer insights into the molecular characteristics of brain areas supporting, for example, complex cognitive functions. Here, we use principal component analysis to separate general and unique gene regulatory associations with cortical substrates of cognition...
March 2024: Human Brain Mapping
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JOURNAL ARTICLE
Jeffrey K Lee, Christopher D Jensen, Natalia Udaltsova, Yingye Zheng, Theodore R Levin, Jessica Chubak, Aruna Kamineni, Ethan A Halm, Celette S Skinner, Joanne E Schottinger, Nirupa R Ghai, Andrea Burnett-Hartman, Rachel Issaka, Douglas A Corley
OBJECTIVE: Colonoscopy surveillance guidelines categorize individuals as high or low risk for future colorectal cancer (CRC) based primarily on their prior polyp characteristics, but the approach is imprecise, and consideration of other risk factors may improve post-polypectomy risk stratification. METHODS: Among patients who underwent a baseline colonoscopy with removal of a conventional adenoma in 2004-2016, we compared the performance for post-polypectomy CRC risk prediction (through 2020) of a comprehensive model featuring patient age, diabetes diagnosis, and baseline colonoscopy indication and prior polyp findings (i...
February 14, 2024: American Journal of Gastroenterology
#5
Tyler C Chervo, Eric P Elkin, Joshua R Nugent, Emily Valice, Laura B Amsden, Isaac J Ergas, Julie R Munneke, Monica Flores, Gina N Saelee, Crystal A Hsiao, Jeffery M Schapiro, Charles P Quesenberry, Douglas A Corley, Laurel A Habel, Lawrence H Kushi, Jacek Skarbinski
BACKGROUND: Understanding the relative contributions of SARS-CoV-2 infection-induced and vaccine- induced seroprevalence is key to measuring overall population-level seroprevalence and help guide policy decisions. METHODS: Using a series of six population-based cross-sectional surveys conducted among persons aged ≥7 years in a large health system with over 4.5 million members between May 2021 and April 2022, we combined data from the electronic health record (EHR), an electronic survey and SARS-CoV-2 spike antibody binding assay, to assess the relative contributions of infection and vaccination to population- level SARS-CoV-2 seroprevalence...
February 2, 2024: medRxiv
#6
JOURNAL ARTICLE
Reinier G S Meester, Iris Lansdorp-Vogelaar, Sidney J Winawer, Timothy R Church, John I Allen, Andrew D Feld, Glenn Mills, Paul A Jordan, Douglas A Corley, Chyke A Doubeni, Anne I Hahn, Stephanie M Lobaugh, Martin Fleisher, Michael J O'Brien, Ann G Zauber
INTRODUCTION: Modeling supporting recommendations for colonoscopy and stool-based colorectal cancer (CRC) screening tests assumes 100% sequential participant adherence. The impact of observed adherence on the long-term effectiveness of screening is unknown. We evaluated the effectiveness of a program of screening-colonoscopy every ten years versus annual high-sensitivity guaiac-based fecal occult blood testing (HSgFOBT) using observed sequential adherence data. METHODS: MIcrosimulation SCreening ANalysis (MISCAN) model using observed sequential screening adherence, HSgFOBT positivity, and diagnostic-colonoscopy adherence in HSgFOBT-positive individuals from the National Colonoscopy Study (NCS; single screening-colonoscopy versus ≥4 HSgFOBT sequential rounds)...
February 6, 2024: American Journal of Gastroenterology
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JOURNAL ARTICLE
Jeffrey K Lee, Pradeep C Koripella, Christopher D Jensen, Sophie A Merchant, Jeffrey M Fox, Suyi X Chang, Christian H Dang, Fernando S Velayos, Eshandeep S Boparai, Nicole S Evans, Lawrence J Leung, Jessica M Badalov, Charles P Quesenberry, Douglas A Corley, Theodore R Levin
BACKGROUND AND AIMS: Guidelines now recommend patients with low-risk adenomas receive colonoscopy surveillance in 7-10 years and those with the previously recommended 5-year interval be reevaluated. We tested three outreach approaches for transitioning patients to the 10-year interval recommendation. METHODS: Design: 3-arm pragmatic randomized trial comparing telephone, secure messaging, and mailed letter outreach. SETTING: Kaiser Permanente Northern California, a large integrated healthcare system...
January 6, 2024: Clinical Gastroenterology and Hepatology
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Lishomwa C Ndhlovu, Matthew L Bendall, Varun Dwaraka, Alina Ps Pang, Nicholas Dopkins, Natalia Carreras, Ryan Smith, Douglas F Nixon, Michael J Corley
Human endogenous retroviruses (HERVs), the remnants of ancient viral infections embedded within the human genome, and long interspersed nuclear elements 1 (LINE-1), a class of autonomous retrotransposons, are silenced by host epigenetic mechanisms including DNA methylation. The resurrection of particular retroelements has been linked to biological aging. Whether the DNA methylation states of locus specific HERVs and LINEs can be used as a biomarker of chronological age in humans remains unclear. We show that highly predictive epigenetic clocks of chronological age can be constructed from retroelement DNA methylation states in the immune system, across human tissues, and pan-mammalian species...
December 7, 2023: bioRxiv
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JOURNAL ARTICLE
Amy Trentham-Dietz, Douglas A Corley, Natalie J Del Vecchio, Robert T Greenlee, Jennifer S Haas, Rebecca A Hubbard, Amy E Hughes, Jane J Kim, Sarah Kobrin, Christopher I Li, Rafael Meza, Christine M Neslund-Dudas, Jasmin A Tiro
Population models of cancer reflect the overall US population by drawing on numerous existing data resources for parameter inputs and calibration targets. Models require data inputs that are appropriately representative, collected in a harmonized manner, have minimal missing or inaccurate values, and reflect adequate sample sizes. Data resource priorities for population modeling to support cancer health equity include increasing the availability of data that 1) arise from uninsured and underinsured individuals and those traditionally not included in health-care delivery studies, 2) reflect relevant exposures for groups historically and intentionally excluded across the full cancer control continuum, 3) disaggregate categories (race, ethnicity, socioeconomic status, gender, sexual orientation, etc...
November 8, 2023: Journal of the National Cancer Institute. Monographs
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JOURNAL ARTICLE
Minta Thomas, Yu-Ru Su, Elisabeth A Rosenthal, Lori C Sakoda, Stephanie L Schmit, Maria N Timofeeva, Zhishan Chen, Ceres Fernandez-Rozadilla, Philip J Law, Neil Murphy, Robert Carreras-Torres, Virginia Diez-Obrero, Franzel J B van Duijnhoven, Shangqing Jiang, Aesun Shin, Alicja Wolk, Amanda I Phipps, Andrea Burnett-Hartman, Andrea Gsur, Andrew T Chan, Ann G Zauber, Anna H Wu, Annika Lindblom, Caroline Y Um, Catherine M Tangen, Chris Gignoux, Christina Newton, Christopher A Haiman, Conghui Qu, D Timothy Bishop, Daniel D Buchanan, David R Crosslin, David V Conti, Dong-Hyun Kim, Elizabeth Hauser, Emily White, Erin Siegel, Fredrick R Schumacher, Gad Rennert, Graham G Giles, Heather Hampel, Hermann Brenner, Isao Oze, Jae Hwan Oh, Jeffrey K Lee, Jennifer L Schneider, Jenny Chang-Claude, Jeongseon Kim, Jeroen R Huyghe, Jiayin Zheng, Jochen Hampe, Joel Greenson, John L Hopper, Julie R Palmer, Kala Visvanathan, Keitaro Matsuo, Koichi Matsuda, Keum Ji Jung, Li Li, Loic Le Marchand, Ludmila Vodickova, Luis Bujanda, Marc J Gunter, Marco Matejcic, Mark A Jenkins, Martha L Slattery, Mauro D'Amato, Meilin Wang, Michael Hoffmeister, Michael O Woods, Michelle Kim, Mingyang Song, Motoki Iwasaki, Mulong Du, Natalia Udaltsova, Norie Sawada, Pavel Vodicka, Peter T Campbell, Polly A Newcomb, Qiuyin Cai, Rachel Pearlman, Rish K Pai, Robert E Schoen, Robert S Steinfelder, Robert W Haile, Rosita Vandenputtelaar, Ross L Prentice, Sébastien Küry, Sergi Castellví-Bel, Shoichiro Tsugane, Sonja I Berndt, Soo Chin Lee, Stefanie Brezina, Stephanie J Weinstein, Stephen J Chanock, Sun Ha Jee, Sun-Seog Kweon, Susan Vadaparampil, Tabitha A Harrison, Taiki Yamaji, Temitope O Keku, Veronika Vymetalkova, Volker Arndt, Wei-Hua Jia, Xiao-Ou Shu, Yi Lin, Yoon-Ok Ahn, Zsofia K Stadler, Bethany Van Guelpen, Cornelia M Ulrich, Elizabeth A Platz, John D Potter, Christopher I Li, Reinier Meester, Victor Moreno, Jane C Figueiredo, Graham Casey, Iris Lansdorp Vogelaar, Malcolm G Dunlop, Stephen B Gruber, Richard B Hayes, Paul D P Pharoah, Richard S Houlston, Gail P Jarvik, Ian P Tomlinson, Wei Zheng, Douglas A Corley, Ulrike Peters, Li Hsu
Polygenic risk scores (PRS) have great potential to guide precision colorectal cancer (CRC) prevention by identifying those at higher risk to undertake targeted screening. However, current PRS using European ancestry data have sub-optimal performance in non-European ancestry populations, limiting their utility among these populations. Towards addressing this deficiency, we expand PRS development for CRC by incorporating Asian ancestry data (21,731 cases; 47,444 controls) into European ancestry training datasets (78,473 cases; 107,143 controls)...
October 2, 2023: Nature Communications
#11
JOURNAL ARTICLE
Jesse N Weber, Wataru Kojima, Romain P Boisseau, Teruyuki Niimi, Shinichi Morita, Shuji Shigenobu, Hiroki Gotoh, Kunio Araya, Chung-Ping Lin, Camille Thomas-Bulle, Cerisse E Allen, Wenfei Tong, Laura Corley Lavine, Brook O Swanson, Douglas J Emlen
What limits the size of nature's most extreme structures? For weapons like beetle horns, one possibility is a tradeoff associated with mechanical levers: as the output arm of the lever system-the beetle horn-gets longer, it also gets weaker. This "paradox of the weakening combatant" could offset reproductive advantages of additional increases in weapon size. However, in contemporary populations of most heavily weaponed species, males with the longest weapons also tend to be the strongest, presumably because selection drove the evolution of compensatory changes to these lever systems that ameliorated the force reductions of increased weapon size...
September 15, 2023: Current Biology: CB
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JOURNAL ARTICLE
Ekaterina Plys, Jean-Luc Bulliard, Aziz Chaouch, Marie-Anne Durand, Luuk A van Duuren, Karen Brändle, Reto Auer, Florian Froehlich, Iris Lansdorp-Vogelaar, Douglas A Corley, Kevin Selby
BACKGROUND: Incidence of and mortality from colorectal cancer (CRC) can be effectively reduced by screening with the fecal immunochemical test (FIT) or colonoscopy. Individual risk to develop CRC within 15 years varies from <1% to >15% among people aged 50 to 75 years. Communicating personalized CRC risk and appropriate screening recommendations could improve the risk-benefit balance of screening test allocations and optimize the use of limited colonoscopy resources. However, significant uncertainty exists regarding the feasibility and efficacy of risk-based screening...
September 7, 2023: JMIR Research Protocols
#13
JOURNAL ARTICLE
Ronit R Dalmat, Rebecca A Ziebell, Aruna Kamineni, Amanda I Phipps, Noel S Weiss, Erica S Breslau, Andrea N Burnett-Hartman, Douglas A Corley, V Paul Doria-Rose, Beverly B Green, Ethan A Halm, Theodore R Levin, Joanne E Schottinger, Jessica Chubak
BACKGROUND: Colorectal cancer (CRC) screening is universally recommended for adults ages 45-75 years. Noninvasive fecal occult blood tests are effective screening tests recommended by guidelines. However, empirical evidence to inform older adults' decisions about whether to continue screening is sparse, especially for individuals with prior screening. METHODS: This study used a retrospective cohort of older adults at three Kaiser Permanente integrated healthcare systems (Northern California, Southern California, Washington) and Parkland Health (Dallas, Texas)...
July 14, 2023: Cancer Epidemiology, Biomarkers & Prevention
#14
JOURNAL ARTICLE
Stephanie Prausnitz, Andrea Altschuler, Lisa J Herrinton, Andrew L Avins, Douglas A Corley
INTRODUCTION: Learning health systems require rapid-cycle research and nimble implementation processes to maximize innovation across disparate specialties and operations. Existing detailed research-to-implementation frameworks require extensive time commitments and can be overwhelming for physician-researchers with clinical and operational responsibilities, inhibiting their widespread adoption. The creation of a short, pragmatic checklist to inform implementation processes may substantially improve uptake and implementation efficiency across a variety of health systems...
July 2023: Learning Health Systems
#15
JOURNAL ARTICLE
Douglas A Corley, Christopher D Jensen, Jessica Chubak, Joanne E Schottinger, Ethan A Halm, Natalia Udaltsova
No abstract text is available yet for this article.
September 2023: Gastroenterology
#16
JOURNAL ARTICLE
Dan Li, Sheng-Fang Jiang, Nan Ye Lei, Shailja C Shah, Douglas A Corley
BACKGROUND & AIMS: High-quality data regarding the effect of Helicobacter pylori eradication on the risk of noncardia gastric adenocarcinoma (NCGA) remain limited in the United States. We investigated the incidence of NCGA after H pylori eradication therapy in a large, community-based US population. METHODS: We performed a retrospective cohort study of Kaiser Permanente Northern California members who underwent testing and/or treatment for H pylori between 1997 and 2015 and were followed through December 31, 2018...
August 2023: Gastroenterology
#17
JOURNAL ARTICLE
Douglas A Corley, Christopher D Jensen, Jeffrey K Lee, Theodore R Levin, Wei K Zhao, Joanne E Schottinger, Nirupa R Ghai, Chyke A Doubeni, Ethan A Halm, Celette Sugg-Skinner, Natalia Udaltsova, Richard Contreras, Bruce H Fireman, Charles P Quesenberry
BACKGROUND AND AIMS: Endoscopist adenoma detection rates (ADR) vary widely and are associated with patients' risk of post-colonoscopy colorectal cancers (PCCRC). However, few scalable physician-directed interventions demonstrably both improve ADR and reduce PCCRC risk. METHODS: Among patients undergoing colonoscopy, we evaluated a scalable online training's influence on individual-level ADRs and PCCRC risk. The intervention was a 30-minute, interactive, online training, developed using behavior-change theory to address factors that potentially impede adenoma detection...
April 22, 2023: Gastrointestinal Endoscopy
#18
Joanna E Moodie, Sarah E Harris, Mat A Harris, Colin R Buchanan, Gail Davies, Adele Taylor, Paul Redmond, David Liewald, Maria Del C Valdés Hernández, Susan Shenkin, Tom C Russ, Susana Muñoz Maniega, Michelle Luciano, Janie Corley, Aleks Stolicyn, Xueyi Shen, Douglas Steele, Gordon Waiter, Anca Sandu-Giuraniuc, Mark E Bastin, Joanna M Wardlaw, Andrew McIntosh, Heather Whalley, Elliot M Tucker-Drob, Ian J Deary, Simon R Cox
Gene expression varies across the brain. This spatial patterning denotes specialised support for particular brain functions. However, general rules may govern shared spatial fluctuations in expression across the genome. Such information would offer insights into the molecular characteristics of brain areas supporting, for example, complex cognitive functions. We find that the region-to-region variation in cortical expression profiles of 8235 genes covary across two major dimensions: cell-signalling/modification and transcription factors...
March 17, 2023: bioRxiv
#19
JOURNAL ARTICLE
Jeffrey K Lee, James H-E Kang, Sophie A Merchant, Christopher D Jensen, Nicholas E Burr, Douglas A Corley
No abstract text is available yet for this article.
March 23, 2023: Clinical Gastroenterology and Hepatology
#20
JOURNAL ARTICLE
Rosita van den Puttelaar, Reinier G S Meester, Elisabeth E P Peterse, Ann G Zauber, Jiayin Zheng, Richard B Hayes, Yu-Ru Su, Jeffrey K Lee, Minta Thomas, Lori C Sakoda, Yi Li, Douglas A Corley, Ulrike Peters, Li Hsu, Iris Lansdorp-Vogelaar
BACKGROUND AND AIMS: Previous studies on the cost-effectiveness of personalized colorectal cancer (CRC) screening were based on hypothetical performance of CRC risk prediction and did not consider the association with competing causes of death. In this study, we estimated the cost-effectiveness of risk-stratified screening using real-world data for CRC risk and competing causes of death. METHODS: Risk predictions for CRC and competing causes of death, from a large community-based cohort, were used to stratify individuals into risk groups...
March 9, 2023: Clinical Gastroenterology and Hepatology
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