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https://www.readbyqxmd.com/read/27914225/cortical-stimulation-parameters-for-functional-mapping
#1
Jacquelyn A Corley, Pouya Nazari, Vincent J Rossi, Nora C Kim, Louis F Fogg, Thomas J Hoeppner, Travis R Stoub, Richard W Byrne
PURPOSE: There is significant variation in how patients respond to cortical electrical stimulation. It has been hypothesized that individual demographic and pathologic factors, such as age, sex, disease duration, and MRI findings, may explain this discrepancy. The purpose of our study is to identify specific patient characteristics and their effect on cortical stimulation, and discover the extent of variation in behavioral responses that exists among patients with epilepsy. METHOD: We retrospectively analyzed data from 92 patients with medically intractable epilepsy who had extra-operative cortical electrical stimulation...
November 23, 2016: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/27890768/proton-pump-inhibitor-and-histamine-2-receptor-antagonist-use-and-iron-deficiency
#2
Jameson R Lam, Jennifer L Schneider, Charles P Quesenberry, Douglas A Corley
BACKGROUND AND AIMS: Proton pump inhibitors (PPIs) and histamine-2 receptor antagonists (H2RAs) suppress gastric acid production, which may inhibit iron absorption. However, little data exist regarding whether these medications increase the risk of clinical iron deficiency. METHODS: A community-based case-control study evaluated the association between acid-suppressing medication use and the subsequent risk of iron deficiency. It contrasted 77,046 patients with new iron deficiency diagnoses (January, 1999-December, 2013), with 389,314 controls...
November 24, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27863244/epigenetic-activation-of-wnt5a-drives-glioblastoma-stem-cell-differentiation-and-invasive-growth
#3
Baoli Hu, Qianghu Wang, Y Alan Wang, Sujun Hua, Charles-Etienne Gabriel Sauvé, Derrick Ong, Zheng D Lan, Qing Chang, Yan Wing Ho, Marta Moreno Monasterio, Xin Lu, Yi Zhong, Jianhua Zhang, Pingna Deng, Zhi Tan, Guocan Wang, Wen-Ting Liao, Lynda J Corley, Haiyan Yan, Junxia Zhang, Yongping You, Ning Liu, Linbo Cai, Gaetano Finocchiaro, Joanna J Phillips, Mitchel S Berger, Denise J Spring, Jian Hu, Erik P Sulman, Gregory N Fuller, Lynda Chin, Roeland G W Verhaak, Ronald A DePinho
Glioblastoma stem cells (GSCs) are implicated in tumor neovascularization, invasiveness, and therapeutic resistance. To illuminate mechanisms governing these hallmark features, we developed a de novo glioblastoma multiforme (GBM) model derived from immortalized human neural stem/progenitor cells (hNSCs) to enable precise system-level comparisons of pre-malignant and oncogene-induced malignant states of NSCs. Integrated transcriptomic and epigenomic analyses uncovered a PAX6/DLX5 transcriptional program driving WNT5A-mediated GSC differentiation into endothelial-like cells (GdECs)...
November 17, 2016: Cell
https://www.readbyqxmd.com/read/27850072/432-impact-of-educational-lecture-on-novel-nutrition-support-service
#4
Rafael Barrera, Brooke Romano, Alison Corley, Garry Ritter, Matthew Shebes, Joann Amarga, Evangelia Davanos
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27827875/rna-sequencing-of-contaminated-seeds-reveals-the-state-of-the-seed-permissive-for-pre-harvest-aflatoxin-contamination-and-points-to-a-potential-susceptibility-factor
#5
Josh Clevenger, Kathleen Marasigan, Vasileios Liakos, Victor Sobolev, George Vellidis, Corley Holbrook, Peggy Ozias-Akins
Pre-harvest aflatoxin contamination (PAC) is a major problem facing peanut production worldwide. Produced by the ubiquitous soil fungus, Aspergillus flavus, aflatoxin is the most naturally occurring known carcinogen. The interaction between fungus and host resulting in PAC is complex, and breeding for PAC resistance has been slow. It has been shown that aflatoxin production can be induced by applying drought stress as peanut seeds mature. We have implemented an automated rainout shelter that controls temperature and moisture in the root and peg zone to induce aflatoxin production...
November 3, 2016: Toxins
https://www.readbyqxmd.com/read/27807125/a-genetic-epidemiological-mega-analysis-of-smoking-initiation-in-adolescents
#6
Hermine H Maes, Elizabeth Prom-Wormley, Lindon J Eaves, Soo Hyun Rhee, John K Hewitt, Susan Young, Robin Corley, Matt McGue, William G Iacono, Lisa Legrand, Di Samek, E Lenn Murrelle, Judy L Silberg, Donna Miles, Richard M Schieken, Gaston P Beunen, Martine Thomis, Richard J Rose, Danielle M Dick, Dorret I Boomsma, Meike Bartels, Jacqueline M Vink, Paul Lichtenstein, Victoria White, Jaakko Kaprio, Michael C Neale
INTRODUCTION: Previous studies in adolescents were not adequately powered to accurately disentangle genetic and environmental influences on smoking initiation across adolescence. METHODS: Mega-analysis of pooled genetically informative data on smoking initiation was performed, with structural equation modeling, to test equality of prevalence and correlations across cultural backgrounds, and to estimate the significance and effect size of genetic and environmental effects according to the classical twin study, in adolescent male and female twins from same-sex and opposite-sex twin pairs (N=19 313 pairs) between age 10 and 19, with 76 358 longitudinal assessments between 1983 and 2007, from 11 population-based twin samples from the US, Europe and Australia RESULTS: Although prevalences differed between samples, twin correlations did not, suggesting similar etiology of smoking initiation across developed countries...
November 2, 2016: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/27788777/test-for-association-of-common-variants-in-grm7-with-alcohol-consumption
#7
Whitney E Melroy-Greif, Csaba Vadasz, Helen M Kamens, Matthew B McQueen, Robin P Corley, Michael C Stallings, Christian J Hopfer, Kenneth S Krauter, Sandra A Brown, John K Hewitt, Marissa A Ehringer
Recent work using a mouse model has identified the glutamate metabotropic receptor 7 (Grm7) gene as a strong candidate gene for alcohol consumption. Although there has been some work examining the effect of human glutamate metabotropic receptor 7 (GRM7) polymorphisms on human substance use disorders, the majority of the work has focused on other psychiatric disorders such as ADHD, major depressive disorder, schizophrenia, bipolar disorder, panic disorder, and autism spectrum disorders. The current study aimed to evaluate evidence for association between GRM7 and alcohol behaviors in humans using a single nucleotide polymorphism (SNP) approach, as well as a gene-based approach...
September 2016: Alcohol
https://www.readbyqxmd.com/read/27759502/an-ovine-model-of-spinal-cord-injury
#8
Saul Wilson, Kingsley O Abode-Iyamah, John W Miller, Chandan G Reddy, Sina Safayi, Douglas C Fredericks, Nicholas D Jeffery, Nicole A DeVries-Watson, Sara K Shivapour, Stephanus Viljoen, Brian D Dalm, Katherine N Gibson-Corley, Michael D Johnson, George T Gillies, Matthew A Howard
OBJECTIVE: To develop a large animal model of spinal cord injury (SCI), for use in translational studies of spinal cord stimulation (SCS) in the treatment of spasticity. We seek to establish thresholds for the SCS parameters associated with reduction of post-SCI spasticity in the pelvic limbs, with implications for patients. STUDY DESIGN: The weight-drop method was used to create a moderate SCI in adult sheep, leading to mild spasticity in the pelvic limbs. Electrodes for electromyography (EMG) and an epidural spinal cord stimulator were then implanted...
October 19, 2016: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/27746152/human-papillomavirus-vaccination-and-subsequent-cervical-cancer-screening-in-a-large-integrated-healthcare-system
#9
Chun Chao, Michael J Silverberg, Tracy A Becerra, Douglas A Corley, Christopher D Jensen, Qiaoling Chen, Virginia P Quinn
BACKGROUND: Human papillomavirus vaccination may result in lowered intention to be screened for cervical cancer, potentially leading to gaps in screening coverage and avoidable cervical cancer diagnoses. OBJECTIVE: To examine the association between human papillomavirus vaccination and subsequent cervical cancer screening initiation and adherence to recommended screening intervals to detect gaps in screening coverage and inform future prevention efforts. STUDY DESIGN: A retrospective cohort study was conducted in two distinct cohorts of female members of Kaiser Permanente Southern California, a large integrated healthcare delivery system...
October 13, 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27743041/predicting-cognitive-executive-functioning-with-polygenic-risk-scores-for-psychiatric-disorders
#10
Chelsie E Benca, Jaime L Derringer, Robin P Corley, Susan E Young, Matthew C Keller, John K Hewitt, Naomi P Friedman
Executive functions (EFs) have been proposed as an endophenotype for psychopathology because EF deficits are associated with most psychiatric disorders. To examine this hypothesis, we derived polygenic risk scores for autism, attention-deficit/hyperactive disorder (ADHD), bipolar disorder, major depression (MDD), and schizophrenia, using genome-wide data from the Psychiatric Genomics Consortium as discovery samples. We then examined the relationships between these polygenic risk scores and three separable EF components measured with a latent variable model...
October 14, 2016: Behavior Genetics
https://www.readbyqxmd.com/read/27738319/interleukin-1-blockade-overcomes-erlotinib-resistance-in-head-and-neck-squamous-cell-carcinoma
#11
Aditya Stanam, Katherine N Gibson-Corley, Laurie Love-Homan, Nnamdi Ihejirika, Andrean L Simons
Erlotinib has demonstrated poor clinical response rates for head and neck squamous cell carcinoma (HNSCC) to date and the majority of respondents acquire resistance to erlotinib relatively quickly. To elucidate novel pathways involved in erlotinib resistance, we compared the gene expression profiles of erlotinib-resistant (ER) vs. erlotinib-sensitive (ES) HNSCC cell lines. Enrichment analysis of microarray data revealed a deregulation of the IL-1 signaling pathway in ER versus ES-HNSCC cells. Gene expression of interleukin-1 alpha (IL1A) and interleukin-1 beta (IL1B) were significantly upregulated by > 2 fold in ER-SQ20B and ER-CAL 27 cells compared to their respective ES-cells...
October 12, 2016: Oncotarget
https://www.readbyqxmd.com/read/27733426/effectiveness-of-screening-colonoscopy-in-reducing-the-risk-of-death-from-right-and-left-colon-cancer-a-large-community-based-study
#12
Chyke A Doubeni, Douglas A Corley, Virginia P Quinn, Christopher D Jensen, Ann G Zauber, Michael Goodman, Jill R Johnson, Shivan J Mehta, Tracy A Becerra, Wei K Zhao, Joanne Schottinger, V Paul Doria-Rose, Theodore R Levin, Noel S Weiss, Robert H Fletcher
OBJECTIVE: Screening colonoscopy's effectiveness in reducing colorectal cancer mortality risk in community populations is unclear, particularly for right-colon cancers, leading to recommendations against its use for screening in some countries. This study aimed to determine whether, among average-risk people, receipt of screening colonoscopy reduces the risk of dying from both right-colon and left-colon/rectal cancers. DESIGN: We conducted a nested case-control study with incidence-density matching in screening-eligible Kaiser Permanente members...
October 12, 2016: Gut
https://www.readbyqxmd.com/read/27733012/constitutive-activation-of-nik-impairs-the-self-renewal-of-hematopoietic-stem-progenitor-cells-and-induces-bone-marrow-failure
#13
Yan Xiu, Wingel Y Xue, Allyn Lambertz, Mariah Leidinger, Katherine Gibson-Corley, Chen Zhao
Previously we have shown that loss of non-canonical NF-κB signaling impairs self-renewal of hematopoietic stem/progenitor cells (HSPCs). This prompted us to investigate whether persistent activation of the non-canonical NF-κB signaling will have supportive effects on HSPC self-renewal. NF-κB-inducing kinase (NIK) is an important kinase that mainly activates the non-canonical pathway through directly phosphorylating IKKα. In contrast to our expectations, constitutive activation of NIK in the hematopoietic system leads to bone marrow (BM) failure and postnatal lethality due to intrinsic impairment of HSPC self-renewal and extrinsic disruption of BM microenvironment through enhancing osteoclastogenesis...
October 12, 2016: Stem Cells
https://www.readbyqxmd.com/read/27702568/endoscopist-fatigue-estimates-and-colonoscopic-adenoma-detection-in-a-large-community-based-setting
#14
Alexander Lee, Christopher D Jensen, Amy R Marks, Wei K Zhao, Chyke A Doubeni, Ann G Zauber, Virginia P Quinn, Theodore R Levin, Douglas A Corley
BACKGROUND AND AIMS: Endoscopist fatigue may impact colonoscopy quality, but prior studies conflict, and minimal data exist from community-based practices where most colonoscopies are performed. METHODS: Within a large, community-based integrated healthcare system, we evaluated the associations among 4 measures of endoscopist fatigue and colonoscopic adenoma detection during the years 2010 to 2013. Fatigue measures included afternoon versus morning colonoscopy and the number of GI procedures performed before a given colonoscopy, including consideration of prior procedure complexity...
October 1, 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27680681/%C3%AE-3%C3%AE-1-integrin-suppresses-prostate-cancer-metastasis-via-regulation-of-the-hippo-pathway
#15
Afshin Varzavand, Will Hacker, Deqin Ma, Katherine Gibson-Corley, Maria Hawayek, Omar J Tayh, James A Brown, Michael D Henry, Christopher S Stipp
Existing anticancer strategies focused on disrupting integrin functions in tumor cells or tumor-involved endothelial cells have met limited success. An alternative strategy is to augment integrin-mediated pathways that suppress tumor progression, but how integrins can signal to restrain malignant behavior remains unclear. To address this issue, we generated an in vivo model of prostate cancer metastasis via depletion of α3β1 integrin, a correlation observed in a significant proportion of prostate cancers...
September 28, 2016: Cancer Research
https://www.readbyqxmd.com/read/27668483/on-predicting-form-and-meaning-in-a-second-language
#16
Aine Ito, Andrea E Martin, Mante S Nieuwland
We used event-related potentials (ERP) to investigate whether Spanish-English bilinguals preactivate form and meaning of predictable words. Participants read high-cloze sentence contexts (e.g., "The student is going to the library to borrow a . . ."), followed by the predictable word (book), a word that was form-related (hook) or semantically related (page) to the predictable word, or an unrelated word (sofa). Word stimulus onset synchrony (SOA) was 500 ms (Experiment 1) or 700 ms (Experiment 2). In both experiments, all nonpredictable words elicited classic N400 effects...
September 26, 2016: Journal of Experimental Psychology. Learning, Memory, and Cognition
https://www.readbyqxmd.com/read/27664981/associations-between-education-and-brain-structure-at-age-73-years-adjusted-for-age-11-iq
#17
Simon R Cox, David Alexander Dickie, Stuart J Ritchie, Sherif Karama, Alison Pattie, Natalie A Royle, Janie Corley, Benjamin S Aribisala, Maria Valdés Hernández, Susana Muñoz Maniega, John M Starr, Mark E Bastin, Alan C Evans, Joanna M Wardlaw, Ian J Deary
OBJECTIVE: To investigate how associations between education and brain structure in older age were affected by adjusting for IQ measured at age 11. METHODS: We analyzed years of full-time education and measures from an MRI brain scan at age 73 in 617 community-dwelling adults born in 1936. In addition to average and vertex-wise cortical thickness, we measured total brain atrophy and white matter tract fractional anisotropy. Associations between brain structure and education were tested, covarying for sex and vascular health; a second model also covaried for age 11 IQ...
September 24, 2016: Neurology
https://www.readbyqxmd.com/read/27642846/selecting-against-accidental-rna-interactions
#18
Meredith Corley, Alain Laderach
Random base-pairing interactions between messenger RNAs and noncoding RNAs can reduce translation efficiency.
2016: ELife
https://www.readbyqxmd.com/read/27631980/the-role-of-nurses-and-community-health-workers-in-confronting-neglected-tropical-diseases-in-sub-saharan-africa-a-systematic-review
#19
REVIEW
Andrew G Corley, Clifton P Thornton, Nancy E Glass
INTRODUCTION: Neglected tropical diseases produce an enormous burden on many of the poorest and most disenfranchised populations in sub-Saharan Africa. Similar to other developing areas throughout the world, this region's dearth of skilled health providers renders Western-style primary care efforts to address such diseases unrealistic. Consequently, many countries rely on their corps of nurses and community health workers to engage with underserved and hard-to-reach populations in order provide interventions against these maladies...
September 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27629381/comparative-dna-methylation-profiling-reveals-an-immunoepigenetic-signature-of-hiv-related-cognitive-impairment
#20
Michael J Corley, Christian Dye, Michelle L D'Antoni, Mary Margaret Byron, Kaahukane Leite-Ah Yo, Annette Lum-Jones, Beau Nakamoto, Victor Valcour, Ivo SahBandar, Cecilia M Shikuma, Lishomwa C Ndhlovu, Alika K Maunakea
Monocytes/macrophages contribute to the neuropathogenesis of HIV-related cognitive impairment (CI); however, considerable gaps in our understanding of the precise mechanisms driving this relationship remain. Furthermore, whether a distinct biological profile associated with HIV-related CI resides in immune cell populations remains unknown. Here, we profiled DNA methylomes and transcriptomes of monocytes derived from HIV-infected individuals with and without CI using genome-wide DNA methylation and gene expression profiling...
September 15, 2016: Scientific Reports
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