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JOURNAL ARTICLE
William B Ventres, Leslie A Stone, Radeeb Akhtar, Jeffrey M Ring, Lucy M Candib, Erick Messias, Ronald M Epstein, Marc Tunzi, Amy L Lee, Christopher P Morley, Carina M Brown, David Slawson, Jill Konkin, David G Campbell, Ian Couper, Susan Williams, Robert Brooks, Lucie Walters
Storylines of Family Medicine is a 12-part series of thematically linked mini-essays with accompanying illustrations that explore the many dimensions of family medicine, as interpreted by individual family physicians and medical educators in the USA and elsewhere around the world. In 'IV: perspectives on practice-lenses of appreciation', authors address the following themes: 'Relational connections in the doctor-patient partnership', 'Feminism and family medicine', 'Positive family medicine', 'Mindful practice', 'The new, old ethics of family medicine', 'Public health, prevention and populations', 'Information mastery in family medicine' and 'Clinical courage...
April 12, 2024: Family Medicine and Community Health
#22
JOURNAL ARTICLE
Kyung-Hee Kim, Eun Pyo Hong, Yukyeong Lee, Zachariah L McLean, Emanuela Elezi, Ramee Lee, Seung Kwak, Branduff McAllister, Thomas H Massey, Sergey Lobanov, Peter Holmans, Michael Orth, Marc Ciosi, Darren G Monckton, Jeffrey D Long, Diane Lucente, Vanessa C Wheeler, Marcy E MacDonald, James F Gusella, Jong-Min Lee
Many Mendelian disorders, such as Huntington's disease (HD) and spinocerebellar ataxias, arise from expansions of CAG trinucleotide repeats. Despite the clear genetic causes, additional genetic factors may influence the rate of those monogenic disorders. Notably, genome-wide association studies discovered somewhat expected modifiers, particularly mismatch repair genes involved in the CAG repeat instability, impacting age at onset of HD. Strikingly, FAN1 , previously unrelated to repeat instability, produced the strongest HD modification signals...
April 16, 2024: Proceedings of the National Academy of Sciences of the United States of America
#23
JOURNAL ARTICLE
Huihua Xing, Caleb Wigham, Sieun Ruth Lee, Aramis J Pereira, Luana J de Campos, Agustín S Picco, Cristián Huck-Iriart, Carlos Escudero, Laura Perez-Chirinos, Sandun Gajaweera, Jeffrey Comer, Ivan R Sasselli, Samuel I Stupp, R Helen Zha, Martin Conda-Sheridan
Self-assembled nanostructures such as those formed by peptide amphiphiles (PAs) are of great interest in biological and pharmacological applications. Herein, a simple and widely applicable chemical modification, a urea motif, was included in the PA's molecular structure to stabilize the nanostructures by virtue of intermolecular hydrogen bonds. Since the amino acid residue nearest to the lipid tail is the most relevant for stability, we decided to include the urea modification at that position. We prepared four groups of molecules (13 PAs in all), with varying levels of intermolecular cohesion, using amino acids with distinct β-sheet promoting potential and/or containing hydrophobic tails of distinct lengths...
April 11, 2024: Biomacromolecules
#24
Samantha Madala, Yicheng K Bao, Jun Hui Lee, Jeffrey Gluckstein, Jessica Chang, Sandy Zhang-Nunes
PURPOSE: To report a case of retrograde embolism of cosmetic injection of platelet-rich plasma (PRP) to the ophthalmic artery, resulting in orbital ischemia, blindness, and eventual phthisis bulbi. OBSERVATIONS: A 37-year-old woman presented with two days of vision loss OS beginning seconds after undergoing cosmetic PRP filler injections to the face at an outside clinic. Immediately after injection to the left medial forehead, the patient reported bleeding, transient loss of consciousness, and complete vision loss OS...
June 2024: American Journal of Ophthalmology Case Reports
#25
JOURNAL ARTICLE
Clara Morral, Arshad Ayyaz, Hsuan-Cheng Kuo, Mardi Fink, Ioannis I Verginadis, Andrea R Daniel, Danielle N Burner, Lucy M Driver, Sloane Satow, Stephanie Hasapis, Reem Ghinnagow, Lixia Luo, Yan Ma, Laura D Attardi, Constantinos Koumenis, Andy J Minn, Jeffrey L Wrana, Chang-Lung Lee, David G Kirsch
Ionizing radiation induces cell death in the gastrointestinal (GI) epithelium by activating p53. However, p53 also prevents animal lethality caused by radiation-induced acute GI syndrome. Through single-cell RNA-sequencing of the irradiated mouse small intestine, we find that p53 target genes are specifically enriched in regenerating epithelial cells that undergo fetal-like reversion, including revival stem cells (revSCs) that promote animal survival after severe damage of the GI tract. Accordingly, in mice with p53 deleted specifically in the GI epithelium, ionizing radiation fails to induce fetal-like revSCs...
April 8, 2024: Nature Communications
#26
JOURNAL ARTICLE
Yue Zhou, Gregory A Phelps, Mikayla M Mangrum, Jemma McLeish, Elise K Phillips, Jinchao Lou, Christelle F Ancajas, Jeffrey M Rybak, Peter M Oelkers, Richard E Lee, Michael D Best, Todd B Reynolds
UNLABELLED: Systemic infections by Candida spp. are associated with high mortality rates, partly due to limitations in current antifungals, highlighting the need for novel drugs and drug targets. The fungal phosphatidylserine synthase, Cho1, from Candida albicans is a logical antifungal drug target due to its importance in virulence, absence in the host, and conservation among fungal pathogens. Inhibitors of Cho1 could serve as lead compounds for drug development, so we developed a target-based screen for inhibitors of purified Cho1...
April 9, 2024: MBio
#27
Alton Barbehenn, Lei Shi, Junzhe Shao, Rebecca Hoh, Heather M Hartig, Vivian Pae, Sannidhi Sarvadhavabhatla, Sophia Donaire, Caroline Sheikhzadeh, Jeffrey Milush, Gregory M Laird, Mignot Mathias, Kristen Ritter, Michael Peluso, Jeffrey Martin, Frederick Hecht, Christopher Pilcher, Stephanie E Cohen, Susan Buchbinder, Diane Havlir, Monica Gandhi, Timothy J Henrich, Hiroyu Hatano, Jingshen Wang, Steven G Deeks, Sulggi A Lee
Antiretroviral therapy (ART) is not a cure. Upon ART cessation, virus rapidly rebounds from latently-infected cells ("the HIV reservoir"). The reservoir is largely stabilized at the time of ART initiation and then decays slowly. Here, leveraging >500 longitudinal samples from 67 people with HIV (PWH) treated during acute infection, we developed a novel mathematical model to predict reservoir decay using the intact proviral DNA assay (IPDA) from peripheral CD4+ T cells. Nonlinear generalized additive models adjusted for initial CD4+ T count, pre-ART viral load, and timing of ART initiation demonstrated rapid biphasic decay of intact DNA (week 0-5: t 1/2 ∼0...
March 28, 2024: medRxiv
#28
Minji Kim, Ping Wang, Patricia Clow, I Chien, Xiaotao Wang, Jianhao Peng, Haoxi Chai, Xiyuan Liu, Byoungkoo Lee, Chew Yee Ngan, Feng Yue, Olgica Milenkovic, Jeffrey H Chuang, Chia-Lin Wei, Rafael Casellas, Albert Cheng, Yijun Ruan
Cohesin is required for chromatin loop formation. However, its precise role in regulating gene transcription remains largely unknown. We investigated the relationship between cohesin and RNA Polymerase II (RNAPII) using single-molecule mapping and live-cell imaging methods in human cells. Cohesin-mediated transcriptional loops were highly correlated with those of RNAPII and followed the direction of gene transcription. Depleting RAD21, a subunit of cohesin, resulted in the loss of long-range (>100 kb) loops between distal (super-)enhancers and promoters of cell-type-specific genes...
March 27, 2024: bioRxiv
#29
JOURNAL ARTICLE
Rajesh Rajan, Jeremy Man Ho Hui, Mohammad A Al Jarallah, Gary Tse, Jeffrey Shi Kai Chan, Danish Iltaf Satti, Chloe Tsz Ching Hui, Yuxi Sun, Yan Hiu Athena Lee, Ying Liu, Govindan Vijayaraghavan, Ibrahim Al-Zakwani, Laura AlObaid
BACKGROUND: The dimensionless Rajan's heart failure (R-hf) risk score was proposed to predict all-cause mortality in patients hospitalized with chronic heart failure (HF) and reduced ejection fraction (EF) (HFrEF). PURPOSE: To examine the association between the modified R-hf risk score and all-cause mortality in patients with HFrEF. METHODS: Retrospective cohort study included adults hospitalized with HFrEF, as defined by clinical symptoms of HF with biplane EF less than 40% on transthoracic echocardiography, at a tertiary centre in Dalian, China, between 1 November 2015, and 31 October 2019...
April 2024: Annals of Medicine and Surgery
#30
Aaron M Miller, Jonathan M Holmes, Rui Wu, Raymond T Kraker, Eric R Crouch, Katherine A Lee, Monte A Del Monte, Justin D Marsh, Courtney L Kraus, David K Wallace, Jeffrey D Colburn, Pavlina S Kemp, Susan A Cotter
No abstract text is available yet for this article.
April 2, 2024: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
#31
JOURNAL ARTICLE
Guy Ledergor, Zenghua Fan, Kai Wu, Elizabeth McCarthy, Axel Hyrenius-Wittsten, Alec Starzinski, Hewitt Chang, Mark Bridge, Serena S Kwek, Alexander Cheung, Sophia Anna Bylsma, Erik Hansen, Jeffrey Lee Wolf, Sandy W Wong, Nina Shah, Kole T Roybal, Thomas G Martin, Chun Jimmie Ye, Lawrence Fong
Multiple myeloma is characterized by frequent clinical relapses following conventional therapy. Recently, chimeric antigen receptor T (CAR-T) cells targeting B-cell maturation antigen (BCMA) has been established as a treatment option for patients with relapsed or refractory disease. However, while >70% of patients initially respond to this treatment, clinical relapse and disease progression occur in most cases. Recent studies showed persistent expression of BCMA at the time of relapse, indicating that immune intrinsic mechanisms may contribute to this resistance...
April 4, 2024: Blood Advances
#32
JOURNAL ARTICLE
E Rosenberg, T I Andersen, R Samajdar, A Petukhov, J C Hoke, D Abanin, A Bengtsson, I K Drozdov, C Erickson, P V Klimov, X Mi, A Morvan, M Neeley, C Neill, R Acharya, R Allen, K Anderson, M Ansmann, F Arute, K Arya, A Asfaw, J Atalaya, J C Bardin, A Bilmes, G Bortoli, A Bourassa, J Bovaird, L Brill, M Broughton, B B Buckley, D A Buell, T Burger, B Burkett, N Bushnell, J Campero, H-S Chang, Z Chen, B Chiaro, D Chik, J Cogan, R Collins, P Conner, W Courtney, A L Crook, B Curtin, D M Debroy, A Del Toro Barba, S Demura, A Di Paolo, A Dunsworth, C Earle, L Faoro, E Farhi, R Fatemi, V S Ferreira, L Flores Burgos, E Forati, A G Fowler, B Foxen, G Garcia, É Genois, W Giang, C Gidney, D Gilboa, M Giustina, R Gosula, A Grajales Dau, J A Gross, S Habegger, M C Hamilton, M Hansen, M P Harrigan, S D Harrington, P Heu, G Hill, M R Hoffmann, S Hong, T Huang, A Huff, W J Huggins, L B Ioffe, S V Isakov, J Iveland, E Jeffrey, Z Jiang, C Jones, P Juhas, D Kafri, T Khattar, M Khezri, M Kieferová, S Kim, A Kitaev, A R Klots, A N Korotkov, F Kostritsa, J M Kreikebaum, D Landhuis, P Laptev, K-M Lau, L Laws, J Lee, K W Lee, Y D Lensky, B J Lester, A T Lill, W Liu, A Locharla, S Mandrà, O Martin, S Martin, J R McClean, M McEwen, S Meeks, K C Miao, A Mieszala, S Montazeri, R Movassagh, W Mruczkiewicz, A Nersisyan, M Newman, J H Ng, A Nguyen, M Nguyen, M Y Niu, T E O'Brien, S Omonije, A Opremcak, R Potter, L P Pryadko, C Quintana, D M Rhodes, C Rocque, N C Rubin, N Saei, D Sank, K Sankaragomathi, K J Satzinger, H F Schurkus, C Schuster, M J Shearn, A Shorter, N Shutty, V Shvarts, V Sivak, J Skruzny, W Clarke Smith, R D Somma, G Sterling, D Strain, M Szalay, D Thor, A Torres, G Vidal, B Villalonga, C Vollgraff Heidweiller, T White, B W K Woo, C Xing, Z Jamie Yao, P Yeh, J Yoo, G Young, A Zalcman, Y Zhang, N Zhu, N Zobrist, H Neven, R Babbush, D Bacon, S Boixo, J Hilton, E Lucero, A Megrant, J Kelly, Y Chen, V Smelyanskiy, V Khemani, S Gopalakrishnan, T Prosen, P Roushan
Understanding universal aspects of quantum dynamics is an unresolved problem in statistical mechanics. In particular, the spin dynamics of the one-dimensional Heisenberg model were conjectured as to belong to the Kardar-Parisi-Zhang (KPZ) universality class based on the scaling of the infinite-temperature spin-spin correlation function. In a chain of 46 superconducting qubits, we studied the probability distribution of the magnetization transferred across the chain's center, [Formula: see text]. The first two moments of [Formula: see text] show superdiffusive behavior, a hallmark of KPZ universality...
April 5, 2024: Science
#33
JOURNAL ARTICLE
Samantha Lee, Hind Sbihi, Julia L MacIsaac, Robert Balshaw, Amirthagowri Ambalavanan, Padmaja Subbarao, Piushkumar J Mandhane, Theo J Moraes, Stuart E Turvey, Qingling Duan, Michael Brauer, Jeffrey R Brook, Michael S Kobor, Meaghan J Jones
BACKGROUND: Evidence suggests that prenatal air pollution exposure alters DNA methylation (DNAm), which could go on to affect long-term health. It remains unclear whether DNAm alterations present at birth persist through early life. Identifying persistent DNAm changes would provide greater insight into the molecular mechanisms contributing to the association of prenatal air pollution exposure with atopic diseases. OBJECTIVES: This study investigated DNAm differences associated with prenatal nitrogen dioxide (<mml:math xmlns:mml="https://www...
April 2024: Environmental Health Perspectives
#34
JOURNAL ARTICLE
Paolo Cadinu, Kisha N Sivanathan, Aditya Misra, Rosalind J Xu, Davide Mangani, Evan Yang, Joseph M Rone, Katherine Tooley, Yoon-Chul Kye, Lloyd Bod, Ludwig Geistlinger, Tyrone Lee, Randall T Mertens, Noriaki Ono, Gang Wang, Liliana Sanmarco, Francisco J Quintana, Ana C Anderson, Vijay K Kuchroo, Jeffrey R Moffitt, Roni Nowarski
Gut inflammation involves contributions from immune and non-immune cells, whose interactions are shaped by the spatial organization of the healthy gut and its remodeling during inflammation. The crosstalk between fibroblasts and immune cells is an important axis in this process, but our understanding has been challenged by incomplete cell-type definition and biogeography. To address this challenge, we used multiplexed error-robust fluorescence in situ hybridization (MERFISH) to profile the expression of 940 genes in 1...
April 1, 2024: Cell
#35
JOURNAL ARTICLE
Jeffrey K Lee, Abhik Roy, Christopher D Jensen, Jennifer T Chan, Wei K Zhao, Theodore R Levin, Jessica Chubak, Ethan A Halm, Celette S Skinner, Joanne E Schottinger, Nirupa R Ghai, Andrea N Burnett-Hartman, Aruna Kamineni, Natalia Udaltsova, Douglas A Corley
IMPORTANCE: Postpolypectomy surveillance is a common colonoscopy indication in older adults; however, guidelines provide little direction on when to stop surveillance in this population. OBJECTIVE: To estimate surveillance colonoscopy yields in older adults. DESIGN, SETTING, AND PARTICIPANTS: This population-based cross-sectional study included individuals 70 to 85 years of age who received surveillance colonoscopy at a large, community-based US health care system between January 1, 2017, and December 31, 2019; had an adenoma detected 12 or more months previously; and had at least 1 year of health plan enrollment before surveillance...
April 1, 2024: JAMA Network Open
#36
REVIEW
Kavin Sugumar, Lora Naik, Jonathan J Hue, John B Ammori, Jeffrey M Hardacre, Lee M Ocuin, Jordan M Winter
INTRODUCTION: Nonalcoholic fatty liver disease (NAFLD) occurs in 10-40% of patients following pancreatic resection. Pancreatic exocrine insufficiency (PEI) is thought to be closely associated with NAFLD, however the mechanism of NAFLD is not clearly understood. We perform a systematic review and meta-analysis to better understand the risk factors of NAFLD. METHODS: A systematic literature search was performed in the Medline database. Studies focused on the risk factors associated with NAFLD in patients undergoing pancreatectomy...
March 27, 2024: Journal of Gastrointestinal Surgery
#37
JOURNAL ARTICLE
Ayse Bahar Ercan, Melyssa Aronson, Nicholas R Fernandez, Yuan Chang, Adrian Levine, Zhihui Amy Liu, Logine Negm, Melissa Edwards, Vanessa Bianchi, Lucie Stengs, Jiil Chung, Abeer Al-Battashi, Agnes Reschke, Alex Lion, Alia Ahmad, Alvaro Lassaletta, Alyssa T Reddy, Amir F Al-Darraji, Amish C Shah, An Van Damme, Anne Bendel, Aqeela Rashid, Ashley S Margol, Bethany L Kelly, Bojana Pencheva, Brandie Heald, Brianna Lemieux-Anglin, Bruce Crooks, Carl Koschmann, Catherine Gilpin, Christopher C Porter, David Gass, David Samuel, David S Ziegler, Deborah T Blumenthal, Dennis John Kuo, Dima Hamideh, Donald Basel, Dong-Anh Khuong-Quang, Duncan Stearns, Enrico Opocher, Fernando Carceller, Hagit Baris Feldman, Helen Toledano, Ira Winer, Isabelle Scheers, Ivana Fedorakova, Jack M Su, Jaime Vengoechea, Jaroslav Sterba, Jeffrey Knipstein, Jordan R Hansford, Julieta Rita Gonzales-Santos, Kanika Bhatia, Kevin J Bielamowicz, Khurram Minhas, Kim E Nichols, Kristina A Cole, Lynette Penney, Magnus Aasved Hjort, Magnus Sabel, Maria Joao Gil-da-Costa, Matthew J Murray, Matthew Miller, Maude L Blundell, Maura Massimino, Maysa Al-Hussaini, Mazin F Al-Jadiry, Melanie A Comito, Michael Osborn, Michael P Link, Michal Zapotocky, Mithra Ghalibafian, Najma Shaheen, Naureen Mushtaq, Nicolas Waespe, Nobuko Hijiya, Noemi Fuentes-Bolanos, Olfat Ahmad, Omar Chamdine, Paromita Roy, Pavel N Pichurin, Per Nyman, Rachel Pearlman, Rebecca C Auer, Reghu K Sukumaran, Rejin Kebudi, Rina Dvir, Robert Raphael, Ronit Elhasid, Rose B McGee, Rose Chami, Ryan Noss, Ryuma Tanaka, Salmo Raskin, Santanu Sen, Scott Lindhorst, Sebastien Perreault, Shani Caspi, Shazia Riaz, Shlomi Constantini, Sophie Albert, Stanley Chaleff, Stefan Bielack, Stefano Chiaravalli, Stuart Louis Cramer, Sumita Roy, Suzanne Cahn, Suzanne Penna, Syed Ahmer Hamid, Tariq Ghafoor, Uzma Imam, Valerie Larouche, Vanan Magimairajan Issai, William D Foulkes, Yi Yen Lee, Paul C Nathan, Yosef E Maruvka, Mary-Louise C Greer, Carol Durno, Adam Shlien, Birgit Ertl-Wagner, Anita Villani, David Malkin, Cynthia Hawkins, Eric Bouffet, Anirban Das, Uri Tabori
BACKGROUND: Constitutional mismatch repair deficiency (CMMRD) syndrome is a rare and aggressive cancer predisposition syndrome. Because a scarcity of data on this condition contributes to management challenges and poor outcomes, we aimed to describe the clinical spectrum, cancer biology, and impact of genetics on patient survival in CMMRD. METHODS: In this cohort study, we collected cross-sectional and longitudinal data on all patients with CMMRD, with no age limits, registered with the International Replication Repair Deficiency Consortium (IRRDC) across more than 50 countries...
March 26, 2024: Lancet Oncology
#38
JOURNAL ARTICLE
Luis E Aguirre, Akriti Jain, Somedeb Ball, Najla Al Ali, Virginia O Volpe, Sara Tinsley-Vance, David Sallman, Kendra Sweet, Jeffrey Lancet, Eric Padron, Seongseok Yun, Andrew Kuykendall, Rami Komrokji
BACKGROUND: Myelofibrosis is the most aggressive subtype among classical BCR::ABL1 negative myeloproliferative neoplasms. About 90% of cases are driven by constitutive activation of 1 of 3 genes impacting the JAK/STAT pathway: JAK2, CALR, and MPL. Triple-negative myelofibrosis (TN-MF) accounts for only 5%-10% of cases and carries the worst outcomes. Little has been described about this subset of disease. Given the marked heterogeneity surrounding disease biology, clonal architecture, clinical presentation, and poor outcomes in TN-MF, identification of features of interest and assessment of treatment response are areas in need of further investigation...
March 11, 2024: Clinical Lymphoma, Myeloma & Leukemia
#39
JOURNAL ARTICLE
Shalini Makawita, Sunyoung Lee, Elisabeth Kong, Lawrence N Kwong, Zeyad Abouelfetouh, Anaemy Danner De Armas, Lianchun Xiao, Karthikeyan Murugesan, Natalie Danziger, Dean Pavlick, Anil Korkut, Jeffrey S Ross, Milind Javle
PURPOSE: Isocitrate dehydrogenase ( IDH ) 1 / 2 genomic alterations (GA) occur in 20% of intrahepatic cholangiocarcinoma (iCCA); however, the immunogenomic landscape of IDH1-/2- mutated iCCA is largely unknown. METHODS: Comprehensive genomic profiling (CGP) was performed on 3,067 cases of advanced iCCA. Tumor mutational burden (TMB), PD-L1 expression (Dako 22C3), microsatellite instability (MSI), and genomic loss of heterozygosity (gLOH) as a surrogate marker for homologous recombination deficiency were examined...
March 2024: JCO Precision Oncology
#40
JOURNAL ARTICLE
Jeffrey Zamora Goicoechea, Allison Boughner, Juan José Cirion Lee, Aman Mahajan, Kurt Yeo, Maris Sproga, Tasmin Patel, Claudio Saitta, Christopher Russell, Michael Coughlan, Pasquale Caponnetto, Riccardo Polosa
BACKGROUND: There is only limited information about the health effects of regular vaping. Research on the health status of people who used to smoke faces the challenge that previous smoking may have caused unknown health effects. Only studies of people who vape but have never smoked combustible cigarettes can enable the detection of harms attributable to vaping. Large prospective studies of well-characterized electronic cigarette users with and without a history of combustible cigarette smoking are warranted to establish the long-term effects of regular vaping on respiratory health...
March 28, 2024: JMIR Research Protocols
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