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https://www.readbyqxmd.com/read/29050386/brain-monoamine-oxidase-b-and-a-in-human-parkinsonian-dopamine-deficiency-disorders
#1
Junchao Tong, Gausiha Rathitharan, Jeffrey H Meyer, Yoshiaki Furukawa, Lee-Cyn Ang, Isabelle Boileau, Mark Guttman, Oleh Hornykiewicz, Stephen J Kish
See Jellinger (doi:10.1093/awx190) for a scientific commentary on this article. The enzyme monoamine oxidases (B and A subtypes, encoded by MAOB and MAOA, respectively) are drug targets in the treatment of Parkinson's disease. Inhibitors of MAOB are used clinically in Parkinson's disease for symptomatic purposes whereas the potential disease-modifying effect of monoamine oxidase inhibitors is debated. As astroglial cells express high levels of MAOB, the enzyme has been proposed as a brain imaging marker of astrogliosis, a cellular process possibly involved in Parkinson's disease pathogenesis as elevation of MAOB in astrocytes might be harmful...
September 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29049756/interventions-to-improve-follow-up-of-positive-results-on-fecal-blood-tests-a-systematic-review
#2
Kevin Selby, Christine Baumgartner, Theodore R Levin, Chyke A Doubeni, Ann G Zauber, Joanne Schottinger, Christopher D Jensen, Jeffrey K Lee, Douglas A Corley
Background: Fecal immunochemical testing is the most commonly used method for colorectal cancer screening worldwide. However, its effectiveness is frequently undermined by failure to obtain follow-up colonoscopy after positive test results. Purpose: To evaluate interventions to improve rates of follow-up colonoscopy for adults after a positive result on a fecal test (guaiac or immunochemical). Data Sources: English-language studies from the Cochrane Central Register of Controlled Trials, PubMed, and Embase from database inception through June 2017...
October 17, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29049055/oxidized-regenerated-cellulose-collagen-dressings-review-of-evidence-and-recommendations
#3
Stephanie Wu, Andrew J Applewhite, Jeffrey Niezgoda, Robert Snyder, Jayesh Shah, Breda Cullen, Gregory Schultz, Janis Harrison, Rosemary Hill, Melania Howell, Marcus Speyrer, Howard Utra, Jean de Leon, Wayne Lee, Terry Treadwell
OBJECTIVE: Healthcare systems are being challenged to manage increasing numbers of nonhealing wounds. Wound dressings are one of the first lines of defense in wound management, and numerous options exist. The oxidized regenerated cellulose (ORC)/collagen dressing may offer healthcare providers a robust and cost-effective tool for use in a variety of wounds. DESIGN: A multidisciplinary panel meeting was convened to discuss the use of ORC/collagen dressings in wound care and provide practice recommendations...
November 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29048972/new-persistent-opioid-use-among-patients-with-cancer-after-curative-intent-surgery
#4
Jay Soong-Jin Lee, Hsou Mei Hu, Anthony L Edelman, Chad M Brummett, Michael J Englesbe, Jennifer F Waljee, Jeffrey B Smerage, Jennifer J Griggs, Hari Nathan, Jacqueline S Jeruss, Lesly A Dossett
Purpose The current epidemic of prescription opioid misuse has increased scrutiny of postoperative opioid prescribing. Some 6% to 8% of opioid-naïve patients undergoing noncancer procedures develop new persistent opioid use; however, it is unknown if a similar risk applies to patients with cancer. We sought to define the risk of new persistent opioid use after curative-intent surgery, identify risk factors, and describe changes in daily opioid dose over time after surgery. Methods Using a national data set of insurance claims, we identified patients with cancer undergoing curative-intent surgery from 2010 to 2014...
October 19, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29045846/identification-of-genetically-intact-hiv-1-proviruses-in-specific-cd4-t-cells-from-effectively-treated-participants
#5
Bonnie Hiener, Bethany A Horsburgh, John-Sebastian Eden, Kirston Barton, Timothy E Schlub, Eunok Lee, Susanne von Stockenstrom, Lina Odevall, Jeffrey M Milush, Teri Liegler, Elizabeth Sinclair, Rebecca Hoh, Eli A Boritz, Daniel Douek, Rémi Fromentin, Nicolas Chomont, Steven G Deeks, Frederick M Hecht, Sarah Palmer
Latent replication-competent HIV-1 persists in individuals on long-term antiretroviral therapy (ART). We developed the Full-Length Individual Proviral Sequencing (FLIPS) assay to determine the distribution of latent replication-competent HIV-1 within memory CD4(+) T cell subsets in six individuals on long-term ART. FLIPS is an efficient, high-throughput assay that amplifies and sequences near full-length (∼9 kb) HIV-1 proviral genomes and determines potential replication competency through genetic characterization...
October 17, 2017: Cell Reports
https://www.readbyqxmd.com/read/29035371/lncrna-mir100hg-derived-mir-100-and-mir-125b-mediate-cetuximab-resistance-via-wnt-%C3%AE-catenin-signaling
#6
Yuanyuan Lu, Xiaodi Zhao, Qi Liu, Cunxi Li, Ramona Graves-Deal, Zheng Cao, Bhuminder Singh, Jeffrey L Franklin, Jing Wang, Huaying Hu, Tianying Wei, Mingli Yang, Timothy J Yeatman, Ethan Lee, Kenyi Saito-Diaz, Scott Hinger, James G Patton, Christine H Chung, Stephan Emmrich, Jan-Henning Klusmann, Daiming Fan, Robert J Coffey
De novo and acquired resistance, which are largely attributed to genetic alterations, are barriers to effective anti-epidermal-growth-factor-receptor (EGFR) therapy. To generate cetuximab-resistant cells, we exposed cetuximab-sensitive colorectal cancer cells to cetuximab in three-dimensional culture. Using whole-exome sequencing and transcriptional profiling, we found that the long non-coding RNA MIR100HG and two embedded microRNAs, miR-100 and miR-125b, were overexpressed in the absence of known genetic events linked to cetuximab resistance...
October 16, 2017: Nature Medicine
https://www.readbyqxmd.com/read/29034821/abstracts-and-workshops-7th-national-spinal-cord-injury-conference-november-9-11-2017-fallsview-casino-resort-niagara-falls-ontario-canada
#7
Mir Hatef Shojaei, Mohammad Alavinia, B Catharine Craven, Christiana L Cheng, Tova Plashkes, Tian Shen, Nader Fallah, Suzanne Humphreys, Colleen O'Connell, Angelo Gary Linassi, Chester Ho, Christine Short, Karen Ethans, Rebecca Charbonneau, Jerome Paquet, Vanessa K Noonan, Julio C Furlan, Michael G Fehlings, B Catharine Craven, Jirapat Likitlersuang, Elizabeth Sumitro, Sukhvinder Kalsi-Ryan, José Zariffa, Dalton Wolfe, Stephanie Cornell, Julie Gagliardi, Stephanie Marrocco, Carly S Rivers, Nader Nader Fallah, Vanessa K Noonan, David Whitehurst, Carolyn Schwartz, Joel Finkelstein, B Catharine Craven, Karen Ethans, Colleen O'Connell, Catherine Truchon, Chester Ho, A Gary Linassi, Christine Short, Eve Tsai, Brian Drew, Henry Ahn, Marcel F Dvorak, Jérôme Paquet, Michael G Fehlings, Luc Noreau, Katie Lenz, K Alysse Bailey, David Allison, David Ditor, Justine Baron, Jennifer Tomasone, Dorothyann Curran, Toba Miller, Jeremy Grimshaw, Bastien Moineau, Milad Alizadeh-Meghrazi, Gabriel Stefan, Kei Masani, Milos R Popovic, Elizabeth Sumitro, Jirapat Likitlersuang, Sukhvinder Kalsi-Ryan, José Zariffa, Martha G Garcia-Garcia, Cesar Marquez-Chin, Milos R Popovic, Julio C Furlan, Sivakumar Gulasingam, B Catharine Craven, Julio C Furlan, Sivakumar Gulasingam, B Catharine Craven, Alia Khan, Clara Pujol, Mark Laylor, Nikola Unic, Maureen Pakosh, Kristin Musselman, Louise M Brisbois, B Catharine Craven, Mary C Verrier, Maryleen K Jones, Roberta O'Shea, Sakina Valika, Kaila Holtz, Elena Szefer, Vanessa Noonan, Brian Kwon, Patricia Mills, Cynthia Morin, Anne Harris, Christiana Cheng, Arlene Aspinall, Tova Plashkes, Vanessa K Noonan, Katherine Chan, Mary C Verrier, B Catharine Craven, Chris Alappat, Heather M Flett, Julio C Furlan, Kristin E Musselman, James Milligan, Loretta M Hillier, Craig Bauman, Lindsay Donaldson, Joseph Lee, James Milligan, Joseph Lee, Loretta M Hillier, Karen Slonim, Dalton Wolfe, Lindsay Sleeth, Samantha Jeske, Anna Kras-Dupuis, Stephanie Marrocco, Samantha McRae, Heather Flett, Jennifer Mokry, Joanne Zee, Mark Bayley, Jean-Francois Lemay, Audrey Roy, H Dany Gagnon, Maryleen K Jones, Roberta O'Shea, Renee Theiss, Heather Flett, Kristina Guy, Gillian Johnston, Melanie Kokotow, Sandra Mills, Jennifer Mokry, Patricia Bain, Carol Scovil, Pamela Houghton, Deena Lala, Lyndsay Orr, Paul Holyoke, Dalton Wolfe, Lyndsay Orr, Jillian Brooke, Paul Holyoke, Deena Lala, Pamela Houghton, Kathleen A Martin Ginis, Robert B Shaw, Matthew J Stork, Christopher B McBride, Julio C Furlan, B Catharine Craven, Lora Giangregorio, Sander Hitzig, Naaz Kapadia, Milos R Popovic, Vera Zivanovic, Taufik Valiante, Milos R Popovic, Eleni Patsakos, Louise Brisbois, Farnoosh Farahani, Anita Kaiser, B Catharine Craven, Eleni Patsakos, Anita Kaiser, Louise Brisbois, Farnoosh Farahani, B Catharine Craven, Ben Mortenson, Megan MacGillivray, Sadeghi Mahsa, Jared Adams, Bonita Sawatzky, Patricia Mills, Kelly Arbour-Nicitopoulos, Rebecca Bassett-Gunter, Jennifer Leo, Ritu Sharma, Amy Latimer-Cheung, Timothy Olds, Kathleen Martin Ginis, Marnie Graco, Susan Cross, Chinnaya Thiyagarajan, Shirin Shafazand, Najib Ayas, Rachel Schembri, Lauren Booker, Carmel Nicholls, Patricia Burns, Mark Nash, Sally Green, David J Berlowitz, Samantha Taran, Meredith Rocchi, Kathleen A Martin Ginis, Shane N Sweet, Jeffrey G Caron, Shane N Sweet, Meredith A Rocchi, Walter Zelaya, Shane N Sweet, Austin J Bergquist, Mikael F Del Castillo-Valenzuela, Milos R Popovic, Kei Masani, Karen Ethans, Alan Casey, Micheal Namaka, Dimitri Krassiokov-Enns, Cesar Marquez-Chin, Aaron Marquis, Naaz Desai, Vera Zivanovic, Debbie Hebert, Milos R Popovic, Julio C Furlan, B Catharine Craven, Jonathan McLeod, Audrey Hicks, Cindy Gauthier, Jasmine Arel, Rachel Brosseau, Audrey L Hicks, Dany H Gagnon, Nasrin Nejatbakhsh, Anita Kaiser, Sander L Hitzig, Shauna Cappe, Colleen McGillivray, Hardeep Singh, Jaya Sam, Heather Flett, B Catharine Craven, Mary Verrier, Kristin Musselman, Ryan G L Koh, Purbasha Garai, José Zariffa, Janelle Unger, Alison R Oates, Tarun Arora, Kristin Musselman, Bondi Moshe, Burns Anthony, Sivakumar Gulasingam, B Catharine Craven, Emilie Michalovic, Heather L Gainforth, Justine Baron, Ian D Graham, Shane N Sweet, Brian Chan, B Catharine Craven, Walter Wodchis, Suzanne Cadarette, Murray Krahn, Nicole Mittmann, Keryn Chemtob, Meredith A Rocchi, Kelly Arbour-Nicitopoulos, Dahlia Kairy, Shane N Sweet, Parisa Sabetian, Ryan G L Koh, José Zariffa, Paul Yoo, Stephanie N Iwasa, Robart Babona-Pilipos, Patrick Schneider, Prashanth Velayudhan, Umalkhair Ahmed, Milos R Popovic, Cindi M Morshead, Jaeeun Yoo, Masahiro Shinya, Matija Milosevic, Kei Masani, Sharon Gabison, Sunita Mathur, Ethne Nussbaum, Milos Popovic, Mary C Verrier, Kristin Musselman, Jean-François Lemay, Shane McCullum, Kristina Guy, Kristen Walden, Jose Zariffa, Sukhvinder Kalsi-Ryan, Milad Alizadeh-Meghrazi, Joseph Lee, James Milligan, Matt Smith, Peter Athanasopoulos, Tara Jeji, Jennifer Howcroft, Jeremy Howcroft, Andrea Townson, Rhonda Willms, Tova Plashkes, Sandra Mills, Heather Flett, Carol Scovil, Filomena Mazzella, Helen Morris, Anellina Ventre, Eldon Loh, Stacey Guy, John Kramer, Tara Jeji, Nancy Xia, Swati Mehta, Kathleen A Martin Ginis, Christopher B McBride, Robert B Shaw, Christopher West, Karen Ethans, Colleen O'Connell, Susan Charlifue, Dany H Gagnon, Manuel Jose Escalona Castillo, Martin Vermette, Lívia Pinheiro Carvalho, Antony Karelis, Dahlia Kairy, Mylène Aubertin-Leheudre, Cyril Duclos, Pamela E Houghton, Lyndsay Orr, Paul Holyoke, Anna Kras-Dupuis, Dalton Wolfe, Barry Munro, Michelle Sweeny, B Catharine Craven, Heather Flett, Sander Hitzig, Farnoosh Farahani, S Mohammad Alavinia, Maryam Omidvar, Mark Bayley, Shane N Sweet, Julie Gassaway, Rob Shaw, Minna Hong, Sarah Everhart-Skeels, Bethlyn Houlihan, Anthony Burns, Gerald Bilsky, Indira Lanig, Marnie Graco, Susan Cross, Chinnaya Thiyagarajan, Shirin Shafazand, Najib Ayas, Rachel Schembri, Lauren Booker, Carmel Nicholls, Patricia Burns, Mark Nash, Sally Green, David Berlowitz, Julio C Furlan, Sukhvinder Kalsi-Ryan
No abstract text is available yet for this article.
November 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29031371/asge-endovators-summit-defining-the-role-and-value-of-endoscopic-therapies-in-obesity-management
#8
Marvin Ryou, Kenneth R McQuaid, Christopher C Thompson, Steven Edmundowicz, Klaus Mergener, Barham Abu Dayyeh, Caroline Apovian, Carol Burke, Bipan Chand, Anil Chandraker, Thomas Deas, William Dietz, Brian Dunkin, Opella Ernest, Douglas Faigel, Shawn Garber, Osama Hamdy, Lee Kaplan, Nitin Kumar, Robert Kushner, Michael C Larsen, Herbert Lerner, Glenn Littenberg, Christos Mantzoros, Samer Mattar, Rachel Moore, Mary Rinella, Richard Rothstein, Dean Schillinger, Bonnie Spring, Shelby Sullivan, Jeffrey Tice, John Vargo, Erik Wilson, Karen Woods, Natan Zundel
No abstract text is available yet for this article.
October 11, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29030161/asge-endovators-summit-defining-the-role-and-value-of-endoscopic-therapies-in-obesity-management
#9
Marvin Ryou, Kenneth R McQuaid, Christopher C Thompson, Steven Edmundowicz, Klaus Mergener, Barham Abu Dayyeh, Caroline Apovian, Carol Burke, Bipan Chand, Anil Chandraker, Thomas Deas, William Dietz, Brian Dunkin, Opella Ernest, Douglas Faigel, Shawn Garber, Osama Hamdy, Lee Kaplan, Nitin Kumar, Robert Kushner, Michael C Larsen, Herbert Lerner, Glenn Littenberg, Christos Mantzoros, Samer Mattar, Rachel Moore, Mary Rinella, Richard Rothstein, Dean Schillinger, Bonnie Spring, Shelby Sullivan, Jeffrey Tice, John Vargo, Erik Wilson, Karen Woods, Natan Zundel
No abstract text is available yet for this article.
September 8, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29029452/the-h3k27me3-demethylase-kdm6a-is-suppressed-in-breast-cancer-stem-like-cells-and-enables-the-resolution-of-bivalency-during-the-mesenchymal-epithelial-transition
#10
Joseph H Taube, Nathalie Sphyris, Kelsey S Johnson, Keighley N Reisenauer, Taylor A Nesbit, Robiya Joseph, Geraldine V Vijay, Tapasree R Sarkar, Neeraja A Bhangre, Joon Jin Song, Jeffrey T Chang, Min Gyu Lee, Rama Soundararajan, Sendurai A Mani
The deposition of the activating H3K4me3 and repressive H3K27me3 histone modifications within the same promoter, forming a so-called bivalent domain, maintains gene expression in a repressed but transcription-ready state. We recently reported a significantly increased incidence of bivalency following an epithelial-mesenchymal transition (EMT), a process associated with the initiation of the metastatic cascade. The reverse process, known as the mesenchymal-epithelial transition (MET), is necessary for efficient colonization...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29029063/impact-of-pneumococcal-vaccination-on-pneumonia-hospitalizations-and-related-costs-in-ontario-a-population-based-ecological-study
#11
Dara Lee Luca, Jeffrey C Kwong, Anna Chu, Beate Sander, Ryan O'Reilly, Allison J McGeer, David E Bloom
Background: In Ontario, Canada, pneumococcal conjugate vaccine (PCV) was approved for infants in 2001 and became part of the publicly funded routine immunization schedule in 2005. We assessed the population-level impact of PCV on pneumonia hospitalizations and related costs. Methods: We used the difference-in-differences (DD) approach to evaluate the impact of pneumococcal vaccination on pneumonia hospitalizations and related costs, using non-pneumonia hospitalization as the control condition...
September 26, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29021333/is-risk-standardized-in-hospital-stroke-mortality-an-adequate-proxy-for-risk-standardized-30-day-stroke-mortality-data-findings-from-get-with-the-guidelines-stroke
#12
Mathew J Reeves, Gregg C Fonarow, Haolin Xu, Roland A Matsouaka, Ying Xian, Jeffrey Saver, Lee Schwamm, Eric E Smith
BACKGROUND: Hospital profiling is typically undertaken using risk-standardized 30-day mortality, but obtaining these data for hospitals can be difficult. We sought to determine whether risk-standardized in-hospital mortality could serve as an adequate proxy for risk-standardized 30-day mortality data for the purposes of identifying outlier hospitals. METHODS AND RESULTS: Acute ischemic stroke cases entered into GWTG (Get With The Guidelines)-Stroke between 2003 and 2013 were linked to fee-for-service Medicare files to obtain 30-day mortality...
October 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/29021136/distinct-angiogenic-changes-during-carcinogenesis-defined-by-novel-label-free-dark-field-imaging-in-a-hamster-cheek-pouch-model
#13
Fangyao Hu, Hannah Martin, Amy Frees Martinez, Jeffrey Everitt, Alaattin Erkanli, Walter T Lee, Mark W Dewhirst, Nirmala Ramanujam
There remain gaps in knowledge concerning how vascular morphology evolves during carcinogenesis. In this study, we imaged neovascularization by label-free dark field microscopy of a DMBA-induced hamster cheek pouch model of oral squamous cell carcinoma (SCC). Wavelength-dependent imaging revealed distinct vascular features at different imaging depths and vessel sizes. Vascular tortuosity increased significantly in high-risk lesions, while diameter decreased significantly in hyperplastic and SCC lesions. Large vessels preserved the same trends seen in the original images, whereas small vessels displayed different trends, with length and diameter increasing during carcinogenesis...
October 11, 2017: Cancer Research
https://www.readbyqxmd.com/read/29019859/outcomes-after-phalloplasty-do-transgender-patients-and-multiple-urethral-procedures-carry-a-higher-rate-of-complication
#14
Austin C Remington, Shane D Morrison, Jonathan P Massie, Christopher S Crowe, Afaaf Shakir, Stelios C Wilson, Krishna S Vyas, Gordon K Lee, Jeffrey B Friedrich
INTRODUCTION: Phalloplasty is associated with improved quality-of-life in those with penile defects, and in female-to-male transgender (transmale) patients seeking gender-confirming surgery. However, aggregate complication and outcome data is sparse. This study compares phalloplasty outcomes between transmale and cismale patients and between those with primary versus staged urethroplasty. METHODS: A comprehensive literature search of PubMed, MEDLINE, and Google Scholar databases was conducted for studies relating to phalloplasty...
October 10, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29019177/long-term-survival-after-complete-surgical-resection-and-adjuvant-immunotherapy-for-distant-melanoma-metastases
#15
Mark B Faries, Nicola Mozzillo, Mohammed Kashani-Sabet, John F Thompson, Mark C Kelley, Ronald C DeConti, Jeffrey E Lee, James F Huth, Jeffrey Wagner, Angus Dalgleish, Daniel Pertschuk, Christopher Nardo, Stacey Stern, Robert Elashoff, Guy Gammon, Donald L Morton
BACKGROUND: This phase III study was undertaken to evaluate the efficacy of an allogeneic whole-cell vaccine (Canvaxin™) plus bacillus Calmette-Guerin (BCG) after complete resection of stage IV melanoma. METHODS: After complete resection of ≤5 distant metastases, patients were randomly assigned to BCG+Canvaxin (BCG/Cv) or BCG+placebo (BCG/Pl). The primary endpoint was overall survival (OS); secondary endpoints were disease-free survival (DFS), and immune response measured by skin test (ClinicalTrials...
October 10, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29018046/co-occurrence-of-type-1-diabetes-and-celiac-disease-autoimmunity
#16
William Hagopian, Hye-Seung Lee, Edwin Liu, Marian Rewers, Jin-Xiong She, Anette-G Ziegler, Åke Lernmark, Jorma Toppari, Stephen S Rich, Jeffrey P Krischer, Henry Erlich, Beena Akolkar, Daniel Agardh
BACKGROUND AND OBJECTIVES: Few birth cohorts have prospectively followed development of type 1 diabetes (T1D) and celiac disease (CD) autoimmunities to determine timing, extent of co-occurrence, and associated genetic and demographic factors. METHODS: In this prospective birth cohort study, 8676 children at high genetic risk of both diseases were enrolled and 5891 analyzed in median follow-up of 66 months. Along with demographic factors and HLA-DR-DQ, genotypes for HLA-DPB1 and 5 non-HLA loci conferring risk of both T1D and CD were analyzed...
October 10, 2017: Pediatrics
https://www.readbyqxmd.com/read/28993083/acetabular-revision-arthroplasty-using-an-uncemented-deep-profile-jumbo-component-a-ten-to-sixteen-year-follow-up-study
#17
Jeffrey R McLaughlin, Kyla R Lee
BACKGROUND: The purpose of this study is to evaluate the outcome of revision total hip arthroplasty using an uncemented deep profile jumbo acetabular component in patients who had been followed for a minimum of 10 years postoperatively. METHODS: Between 1997 and 2001, 61 revision total hip arthroplasties were performed in 58 patients, with use of the +5 Deep Profile acetabular shell. The outcome with regard to retention vs re-revision of the acetabular component was determined for every hip...
September 14, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28992867/early-exclusion-of-major-adverse-cardiac-events-in-emergency-department-chest-pain-patients-a-prospective-observational-study
#18
Yuk-Ki Leung, Nga-Man Cheng, Cangel Pui-Yee Chan, Anna Lee, Jeffrey Ka-Tak Wong, Bryan Ping-Yen Yan, Anil Tejbhan Ahuja, Colin Alexander Graham, Timothy Hudson Rainer
BACKGROUND: The current evaluation of patients with chest pain presenting to an emergency department (ED) with suspected acute coronary syndrome (ACS) is a lengthy process involving serial measurements of troponin. OBJECTIVE: We aimed to validate the diagnostic accuracy of a Thrombolysis in Myocardial Infarction (TIMI) score with single high-sensitive cardiac troponin T (hs-cTnT) for early rule out of 30-day major adverse cardiac events (MACE), and to compare the TIMI score with combinations of heart-type fatty acid binding protein (H-FABP) and a modified HEART (history, electrocardiogram, age, risk factors, troponin) score...
September 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28992185/accuracy-of-administrative-data-for-antimicrobial-administration-in-hospitalized-children
#19
Joshua D Courter, Sarah K Parker, Cary Thurm, Matthew P Kronman, Scott J Weissman, Samir S Shah, Adam L Hersh, Thomas V Brogan, Sameer J Patel, Michael J Smith, Brian R Lee, Jason G Newland, Jeffrey S Gerber
Administrative data are often used as a proxy for medication-administration record (MAR) data. Multicenter MAR data were compared retrospectively with administrative data from January 2010 through June 2013 from the Pediatric Health Information Systems database. We found that administrative data were more concordant with bill-upon-administration than bill-upon-dispense data.
August 18, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28987648/patients-comprehension-and-skill-usage-as-a-putative-mediator-of-change-or-an-engaged-target-in-cognitive-therapy-preliminary-findings
#20
Robin B Jarrett, Jeffrey R Vittengl, Lee Anna Clark, Michael E Thase
BACKGROUND: The skills that patients learn in cognitive therapy (CT) and use thereafter may mediate improvement in depression during and after intervention. METHOD: We used a sequential, three-stage design: acute phase (523 outpatients received 12-14 weeks of CT); 8-month experimental phase (responders at higher risk were randomized to continuation phases: C-CT, C-fluoxetine or C-pill placebo); and 24 months of longitudinal, post-treatment follow-up. Path analyses estimated mediation by skill measured by the Skills of Cognitive Therapy (SoCT: Patient and Observer [Therapist] versions)...
September 27, 2017: Journal of Affective Disorders
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