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https://www.readbyqxmd.com/read/29690943/recommendations-for-patient-engagement-in-patient-oriented-emergency-medicine-research
#1
Patrick M Archambault, Colleen McGavin, Katie N Dainty, Shelley L McLeod, Christian Vaillancourt, Jacques S Lee, Jeffrey J Perry, François-Pierre Gauvin, Antoine Boivin
OBJECTIVE: To make pragmatic recommendations on best practices for the engagement of patients in emergency medicine (EM) research. METHODS: We created a panel of expert Canadian EM researchers, physicians, and a patient partner to develop our recommendations. We used mixed methods consisting of 1) a literature review; 2) a survey of Canadian EM researchers; 3) qualitative interviews with key informants; and 4) feedback during the 2017 Canadian Association of Emergency Physicians (CAEP) Academic Symposium...
April 25, 2018: CJEM
https://www.readbyqxmd.com/read/29688013/fragment-based-drug-discovery-of-potent-protein-kinase-c-iota-inhibitors
#2
Jacek Kwiatkowski, Boping Liu, Doris Hui Ying Tee, Guoying Chen, Nur Huda Binte Ahmad, Yun Xuan Wong, Zhi Ying Poh, Shi Hua Ang, Eldwin Sum Wai Tan, Esther Hq Ong, Nurul Dinie Binte Rahad, Anders Poulsen, Vishal Pendharkar, Kanda Sangthongpitag, May Ann Lee, Sugunavathi D/O Sepramaniam, Soo Yei Ho, Joseph Cherian, Jeffrey Hill, Thomas H Keller, Alvin W Hung
Protein Kinase C iota is an atypical kinase implicated in the promotion of different cancer types. A fragment-based screen has identified several hits, from which an azaindole-based scaffold was chosen for optimization. Driven by structure-activity relationship and supported by molecular modelling, a weakly bound fragment was systematically grown into a potent and selective inhibitor against PKC-iota.
April 24, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29687961/human-leukocyte-antigens-antibodies-after-lung-transplantation-primary-results-of-the-halt-study
#3
Ramsey R Hachem, Malek Kamoun, Marie M Budev, Medhat Askar, Vivek N Ahya, James C Lee, Deborah J Levine, Marilyn S Pollack, Gundeep S Dhillon, David Weill, Kenneth B Schechtman, Lorriana E Leard, Jeffrey A Golden, LeeAnn Baxter-Lowe, Thalachallour Mohanakumar, Dolly B Tyan, Roger D Yusen
Donor-specific antibodies (DSA) to mismatched human leukocyte antigens (HLA) are associated with worse outcomes after lung transplantation. To determine the incidence and characteristics of DSA early after lung transplantation, we conducted a prospective multi-center observational study that used standardized treatment and testing protocols. Among 119 transplant recipients, 43 (36%) developed DSA: 6 (14%) developed DSA only to class I HLA, 23 (53%) developed DSA only to class II HLA, and 14 (33%) developed DSA to both class I and class II HLA...
April 24, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29685872/comparative-effectiveness-of-a-technology-facilitated-depression-care-management-model-in-safety-net-primary-care-patients-with-type-2-diabetes-6-month-outcomes-of-a-large-clinical-trial
#4
Shinyi Wu, Kathleen Ell, Haomiao Jin, Irene Vidyanti, Chih-Ping Chou, Pey-Jiuan Lee, Sandra Gross-Schulman, Laura Myerchin Sklaroff, David Belson, Arthur M Nezu, Joel Hay, Chien-Ju Wang, Geoffrey Scheib, Paul Di Capua, Caitlin Hawkins, Pai Liu, Magaly Ramirez, Brian W Wu, Mark Richman, Caitlin Myers, Davin Agustines, Robert Dasher, Alex Kopelowicz, Joseph Allevato, Mike Roybal, Eli Ipp, Uzma Haider, Sharon Graham, Vahid Mahabadi, Jeffrey Guterman
BACKGROUND: Comorbid depression is a significant challenge for safety-net primary care systems. Team-based collaborative depression care is effective, but complex system factors in safety-net organizations impede adoption and result in persistent disparities in outcomes. Diabetes-Depression Care-management Adoption Trial (DCAT) evaluated whether depression care could be significantly improved by harnessing information and communication technologies to automate routine screening and monitoring of patient symptoms and treatment adherence and allow timely communication with providers...
April 23, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29685790/effect-of-trinucleotide-repeats-in-the-huntington-s-gene-on-intelligence
#5
Jessica K Lee, Amy Conrad, Eric Epping, Kathy Mathews, Vincent Magnotta, Jeffrey D Dawson, Peg Nopoulos
BACKGROUND: Huntington's Disease (HD) is caused by an abnormality in the HTT gene. This gene includes trinucleotide repeats ranging from 10 to 35, and when expanded beyond 39, causes HD. We previously reported that CAG repeats in the normal range had a direct and beneficial effect on brain development with higher repeats being associated with higher cognitive function. The current study now expands this line of inquiry to evaluate the effects of CAG repeat throughout the entire spectrum of repeats from 15 to 58...
March 30, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29685405/high-prevalence-of-greater-trochanteric-pain-syndrome-among-patients-presenting-to-spine-clinic-for-evaluation-of-degenerative-lumbar-pathologies
#6
Lee A Tan, Barlas Benkli, Alexander Tuchman, Xudong J Li, Natasha N Desai, Thomas S Bottiglieri, Jeffrey Pavel, Lawrence G Lenke, Ronald A Lehman
BACKGROUND: Greater trochanteric pain syndrome (GTPS) is a relatively common diagnosis among the general population. OBJECTIVE: We aim to determine the prevalence of GTPS among patients who presented to the spine clinic. METHODS: Medical records of patients who were evaluated in the spine clinic were reviewed over a 12-month period (4/1/2016 to 3/31/2017). Patient demographics, presenting symptomatology, physical examination findings, presence or absence of GTPS, medical imaging findings, and interventions were recorded analyzed...
April 20, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29683667/optimization-of-selective-mitogen-activated-protein-kinase-interacting-kinases-1-and-2-mnk1-2-inhibitors-for-the-treatment-of-blast-crisis-leukemia
#7
Hai Yan Yang, Lohitha Rao Chennamaneni, Melvyn Wai Tuck Ho, Shi Hua Ang, Eldwin Sum Wai Tan, Duraiswamy Athisayamani Jeyaraj, Yoon Sheng Yeap, Boping Liu, Esther Hq Ong, Joma Kanikadu Joy, John Liang Kuan Wee, Perlyn Kwek, Priya Retna, Nurul Dinie, Thuy Thi Hanh Nguyen, Shi Jing Tai, Vithya Manoharan, Vishal Pendharkar, Choon Bing Low, Yun Shan Chew, Susmitha Vuddagiri, Kanda Sangthongpitag, Meng Ling Choong, May Ann Lee, Srinivasaraghavan Kannan, Chandra S Verma, Anders Poulsen, Sharon Lim, Charles Chuah, Tiong Sin Ong, Jeffrey Hill, Alex Matter, Kassoum Nacro
Chronic Myeloid Leukemia (CML) is a myeloproliferative disease caused by bcr-abl1, a constitutively active tyrosine kinase fusion gene responsible for an abnormal proliferation of leukemic stem cells (LSCs). Inhibition of BCR-ABL1 kinase activity offers long term relief to CML patients. However, for a proportion of them, BCR-ABL1 inhibition will become ineffective at treating the disease and CML will progress to blast crisis (BC) CML with poor prognosis. BC-CML is often associated with excessive phosphorylated eukaryotic translation initiation factor 4E (eIF4E) which renders LSCs capable of proliferating via self-renewal, oblivious to BCR-ABL1 inhibition...
April 23, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29680418/uvulopalatopharyngoplasty-reduces-the-incidence-of-cardiovascular-complications-caused-by-obstructive-sleep-apnea-results-from-the-national-insurance-service-survey-2007-2014
#8
Heung Man Lee, Hyo Yeol Kim, Jeffrey D Suh, Kyung-Do Han, Jin Kook Kim, Young Chang Lim, Seok-Chan Hong, Jae Hoon Cho
OBJECTIVE: Untreated obstructive sleep apnea (OSA) is a risk factor for cardiovascular disease including myocardial infarction (MI), congestive heart failure (CHF), and atrial fibrillation (AF). Continuous positive airway pressure (CPAP) is an effective treatment for OSA; however, compliance with CPAP can be challenging for some patients. The objective of this study was to investigate whether uvulopalatopharyngoplasty (UPPP) reduced the risk of cardiovascular complications for patients with OSA...
May 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29680003/the-comparative-effectiveness-of-quadratus-lumborum-blocks-and-paravertebral-blocks-in-radical-cystectomy-patients
#9
Austin J Lee, Jonathan G Yabes, Nathan Hale, Ronald L Hrebinko, Jeffrey R Gingrich, Jodi K Maranchie, Mina M Fam, Robert M Turner I I, Benjamin J Davies, Bruce Ben-David, Bruce L Jacobs
INTRODUCTION: Multimodal analgesia is an effective way to control pain and limit opioid use after surgery. The quadratus lumborum block and paravertebral block are two regional anesthesia techniques that leverage multimodal analgesia to improve postoperative pain control. We sought to compare the efficacy of these blocks for pain management following radical cystectomy. MATERIALS AND METHODS: We performed a retrospective review of radical cystectomy patients who received bilateral continuous paravertebral blocks (n = 125) or bilateral single shot quadratus lumborum blocks (n = 50) between 2014-2016...
April 2018: Canadian Journal of Urology
https://www.readbyqxmd.com/read/29677059/pediatric-perioperative-cardiac-arrest-death-in-the-off-hours-a-report-from-wake-up-safe-the-pediatric-quality-improvement-initiative
#10
Robert E Christensen, Angela C Lee, Marie S Gowen, Mallikarjuna R Rettiganti, Jayant K Deshpande, Jeffrey P Morray
BACKGROUND: Pediatric perioperative cardiac arrest (CA) is a rare but catastrophic event. This case-control study aims to analyze the causes, incidence, and outcomes of all pediatric CA reported to Wake Up Safe. Factors associated with CA and mortality after arrest are examined and possible strategies for improving outcomes are considered. METHODS: CA in children was identified from the Wake Up Safe Pediatric Anesthesia Quality Improvement Initiative, a multicenter registry of adverse events in pediatric anesthesia...
April 17, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29672417/preoperative-chemoradiation-for-borderline-resectable-pancreatic-cancer-the-new-standard
#11
Matthew Hg Katz, Michael P Kim, Ching-Wei Tzeng, Jeffrey E Lee
No abstract text is available yet for this article.
April 18, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29671586/a-zirconium-photosensitizer-with-a-long-lived-excited-state-mechanistic-insight-into-photo-induced-single-electron-transfer
#12
Yu Zhang, Tia S Lee, Jeffrey L Petersen, Carsten Milsmann
Time-resolved emission spectroscopy for the luminescent zirconium complex Zr(Me PDP)2 (Me PDP = 2,6-bis(5-methyl-3-phenyl-1H-pyrrol-2-yl)pyridine) revealed a long-lived excited state with a lifetime τ = 325 ± 10 μs. Computational studies using time-dependent density functional theory (TD-DFT) were conducted to identify the nature of the luminescent excited state as a mixed triplet intraligand/ligand-to-metal charge transfer (3 IL/3 LMCT) state. Stern-Volmer experiments showed a strong dependence of the quenching rate on the redox potential of the quencher indicating photo-induced single electron transfer (SET) as the quenching pathway...
April 19, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29670690/discovery-of-ag-120-ivosidenib-a-first-in-class-mutant-idh1-inhibitor-for-the-treatment-of-idh1-mutant-cancers
#13
Janeta Popovici-Muller, René M Lemieux, Erin Artin, Jeffrey O Saunders, Francesco G Salituro, Jeremy Travins, Giovanni Cianchetta, Zhenwei Cai, Ding Zhou, Dawei Cui, Ping Chen, Kimberly Straley, Erica Tobin, Fang Wang, Muriel D David, Virginie Penard-Lacronique, Cyril Quivoron, Véronique Saada, Stéphane de Botton, Stefan Gross, Lenny Dang, Hua Yang, Luke Utley, Yue Chen, Hyeryun Kim, Shengfang Jin, Zhiwei Gu, Gui Yao, Zhiyong Luo, Xiaobing Lv, Cheng Fang, Liping Yan, Andrew Olaharski, Lee Silverman, Scott Biller, Shin-San M Su, Katharine Yen
Somatic point mutations at a key arginine residue (R132) within the active site of the metabolic enzyme isocitrate dehydrogenase 1 (IDH1) confer a novel gain of function in cancer cells, resulting in the production of d-2-hydroxyglutarate (2-HG), an oncometabolite. Elevated 2-HG levels are implicated in epigenetic alterations and impaired cellular differentiation. IDH1 mutations have been described in an array of hematologic malignancies and solid tumors. Here, we report the discovery of AG-120 (ivosidenib), an inhibitor of the IDH1 mutant enzyme that exhibits profound 2-HG lowering in tumor models and the ability to effect differentiation of primary patient AML samples ex vivo...
April 12, 2018: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29669933/requisite-endothelial-reactivation-and-effective-sirna-nanoparticle-targeting-of-etv2-er71-in-tumor-angiogenesis
#14
Ashraf Ul Kabir, Tae-Jin Lee, Hua Pan, Jeffrey C Berry, Karen Krchma, Jun Wu, Fang Liu, Hee-Kyoung Kang, Kristina Hinman, Lihua Yang, Samantha Hamilton, Qingyu Zhou, Deborah J Veis, Robert P Mecham, Samuel A Wickline, Mark J Miller, Kyunghee Choi
Angiogenesis, new blood vessel formation from preexisting vessels, is critical for solid tumor growth. As such, there have been efforts to inhibit angiogenesis as a means to obstruct tumor growth. However, antiangiogenic therapy faces major challenges to the selective targeting of tumor-associated-vessels, as current antiangiogenic targets also disrupt steady-state vessels. Here, we demonstrate that the developmentally critical transcription factor Etv2 is selectively upregulated in both human and mouse tumor-associated endothelial cells (TAECs) and is required for tumor angiogenesis...
April 19, 2018: JCI Insight
https://www.readbyqxmd.com/read/29669917/ribosomal-dna-copy-loss-and-repeat-instability-in-atrx-mutated-cancers
#15
Maheshi Udugama, Elaine Sanij, Hsiao P J Voon, Jinbae Son, Linda Hii, Jeremy D Henson, F Lyn Chan, Fiona T M Chang, Yumei Liu, Richard B Pearson, Paul Kalitsis, Jeffrey R Mann, Philippe Collas, Ross D Hannan, Lee H Wong
ATRX (alpha thalassemia/mental retardation X-linked) complexes with DAXX to deposit histone variant H3.3 into repetitive heterochromatin. Recent genome sequencing studies in cancers have revealed mutations in ATRX and their association with ALT (alternative lengthening of telomeres) activation. Here we report depletion of ATRX in mouse ES cells leads to selective loss in ribosomal RNA gene (rDNA) copy number. Supporting this, ATRX-mutated human ALT-positive tumors also show a substantially lower rDNA copy than ALT-negative tumors...
April 18, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29668903/the-interplay-between-oral-microbiome-lifestyle-factors-and-genetic-polymorphisms-in-the-risk-of-oral-squamous-cell-carcinoma
#16
Jenn-Ren Hsiao, Chan-Chi Chang, Wei-Ting Lee, Cheng-Chih Huang, Chun-Yen Ou, Sen-Tien Tsai, Ken-Chung Chen, Jehn-Shyun Huang, Tung-Yiu Wong, Yu-Hsuan Lai, Yuan-Hua Wu, Wei-Ting Hsueh, Shang-Yin Wu, Chia-Jui Yen, Jang-Yang Chang, Chen-Lin Lin, Ya-Ling Weng, Han-Chien Yang, Yu-Shan Chen, Jeffrey S Chang
Poor oral hygiene may lead to overgrowth of pathogenic oral bacteria, which may induce chronic inflammation to promote the oncogenesis of oral squamous cell carcinoma (OSCC). This study investigated the association between oral bacterial profile and OSCC risk in a case-control study of 138 OSCC cases and 151 controls (88 cases and 90 controls for the discovery group and 50 cases and 61 controls for the validation group). Oral bacterial profiles were characterized by targeted sequencing of the 16S rRNA gene...
April 13, 2018: Carcinogenesis
https://www.readbyqxmd.com/read/29668852/meg-working-memory-n-back-task-reveals-functional-deficits-in-combat-related-mild-traumatic-brain-injury
#17
Ming-Xiong Huang, Sharon Nichols, Ashley Robb-Swan, Annemarie Angeles-Quinto, Deborah L Harrington, Angela Drake, Charles W Huang, Tao Song, Mithun Diwakar, Victoria B Risbrough, Scott Matthews, Royce Clifford, Chung-Kuan Cheng, Jeffrey W Huang, Anusha Sinha, Kate A Yurgil, Zhengwei Ji, Imanuel Lerman, Roland R Lee, Dewleen G Baker
Combat-related mild traumatic brain injury (mTBI) is a leading cause of sustained cognitive impairment in military service members and Veterans. However, the mechanism of persistent cognitive deficits including working memory (WM) dysfunction is not fully understood in mTBI. Few studies of WM deficits in mTBI have taken advantage of the temporal and frequency resolution afforded by electromagnetic measurements. Using magnetoencephalography (MEG) and an N-back WM task, we investigated functional abnormalities in combat-related mTBI...
April 13, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29665615/correction-development-and-validation-of-the-simple-endoscopic-classification-of-diminutive-and-small-colorectal-polyps
#18
Marietta Iacucci, Cristina Trovato, Marco Daperno, Oluseyi Akinola, David Greenwald, Seth A Gross, Arthur Hoffman, Jeffrey Lee, Brendan C Lethebe, Mark Lowerison, Jennifer Nayor, Helmut Neumann, Timo Rath, Silvia Sanduleanu, Prateek Sharma, Ralf Kiesslich, Subrata Ghosh, John R Saltzman
No abstract text is available yet for this article.
April 17, 2018: Endoscopy
https://www.readbyqxmd.com/read/29662201/differential-glucose-requirement-in-skin-homeostasis-and-injury-identifies-a-therapeutic-target-for-psoriasis
#19
Zhuzhen Zhang, Zhenzhen Zi, Eunice E Lee, Jiawei Zhao, Diana C Contreras, Andrew P South, E Dale Abel, Benjamin F Chong, Travis Vandergriff, Gregory A Hosler, Philipp E Scherer, Marcel Mettlen, Jeffrey C Rathmell, Ralph J DeBerardinis, Richard C Wang
Proliferating cells, compared with quiescent cells, are more dependent on glucose for their growth. Although glucose transport in keratinocytes is mediated largely by the Glut1 facilitative transporter, we found that keratinocyte-specific ablation of Glut1 did not compromise mouse skin development and homeostasis. Ex vivo metabolic profiling revealed altered sphingolipid, hexose, amino acid, and nucleotide metabolism in Glut1-deficient keratinocytes, thus suggesting metabolic adaptation. However, cultured Glut1-deficient keratinocytes displayed metabolic and oxidative stress and impaired proliferation...
April 16, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29660528/yield-of-colonoscopy-after-a-positive-result-from-a-fecal-immunochemical-test-oc-light
#20
Muhammad Alsayid, Maneesh H Singh, Rachel Issaka, Victoria Laleau, Lukejohn Day, Jeffrey Lee, James Allison, Ma Somsouk
BACKGROUND & AIMS: The fecal immunochemical test (FIT) is widely used in colorectal cancer (CRC) screening. The OC-Light FIT is 1 of 2 FITs recommended for CRC screening by the Preventive Services Task Force guidelines. However, little is known about its ability to detect CRC in large average-risk populations. METHODS: We performed a retrospective cohort study of patients (50-75 years old) in the San Francisco Health Network who were screened for CRC by OC-Light FIT from August 2010 through June 2015...
April 13, 2018: Clinical Gastroenterology and Hepatology
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