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https://www.readbyqxmd.com/read/29927839/-refining-post-orthognathic-surgery-facial-contour-with-computer-designed-computer-manufactured-cad-cam-alloplastic-implants
#1
Jeffrey H Lee, Leonard B Kaban, Michael J Yaremchuk
BACKGROUND: Le fort I maxillary osteotomies and sagittal split mandibular osteotomies are performed to correct significant dentofacial deformities. The multidimensional skeletal movements, particularly those of large magnitude may result in contour irregularities and facial imbalances. METHODS: Three dimensional images were reconstructed from computed tomographic (CT) scans in patients unhappy with their appearances after Le Fort I advancement and/or bilateral sagittal split osteotomies (BSSO)...
June 14, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29926297/breast-cancer-in-women-with-neurofibromatosis-type-1-nf1-a-comprehensive-case-series-with-molecular-insights-into-its-aggressive-phenotype
#2
Yoon-Sim Yap, Prabhakaran Munusamy, Cindy Lim, Claire H T Chan, Aldo Prawira, Sau-Yeen Loke, Swee-Ho Lim, Kong-Wee Ong, Wei-Sean Yong, Sarah B H Ng, Iain B H Tan, David F Callen, Jeffrey C T Lim, Aye-Aye Thike, Puay-Hoon Tan, Ann S G Lee
PURPOSE: The purpose of the study was to improve the understanding of NF1-associated breast cancer, given the increased risk of breast cancer in this tumour predisposition syndrome and the limited data. METHODS: We identified 18 women with NF1 and breast cancer at our institution. Clinical and pathologic characteristics of NF1-associated breast cancers were compared with 7132 breast cancers in patients without NF1 from our institutional database. Next generation sequencing was performed on DNA from blood and breast cancer specimens available...
June 21, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29923938/predictive-factors-for-central-line-associated-bloodstream-infections-in-pediatric-cardiac-surgery-patients-with-chylothorax
#3
Stephanie G Waterhouse, Jeffrey E Vergales, Mark R Conaway, Laura Lee
OBJECTIVES: To assess the prevalence of central line-associated bloodstream infections in pediatric patients with and without chylothorax after cardiac surgery and identify risk factors that predict those patients at highest risk for developing a central line-associated bloodstream infection. DESIGN: Retrospective single-center cohort study. SETTING: A PICU located within a tertiary-care academic pediatric hospital. PATIENTS: All pediatric patients admitted to the PICU after cardiac surgery between 2008 and 2014...
June 19, 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29916454/pancreatic-cystic-neoplasms-in-real-time-eus
#4
Tejas Kirtane, Lisa Cassani, Daniel Davis, Jeffrey H Lee
No abstract text is available yet for this article.
December 2017: VideoGIE: an official video journal of the American Society for Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29915428/a-precision-oncology-approach-to-the-pharmacological-targeting-of-mechanistic-dependencies-in-neuroendocrine-tumors
#5
Mariano J Alvarez, Prem S Subramaniam, Laura H Tang, Adina Grunn, Mahalaxmi Aburi, Gabrielle Rieckhof, Elena V Komissarova, Elizabeth A Hagan, Lisa Bodei, Paul A Clemons, Filemon S Dela Cruz, Deepti Dhall, Daniel Diolaiti, Douglas A Fraker, Afshin Ghavami, Daniel Kaemmerer, Charles Karan, Mark Kidd, Kyoung M Kim, Hee C Kim, Lakshmi P Kunju, Ülo Langel, Zhong Li, Jeeyun Lee, Hai Li, Virginia LiVolsi, Roswitha Pfragner, Allison R Rainey, Ronald B Realubit, Helen Remotti, Jakob Regberg, Robert Roses, Anil Rustgi, Antonia R Sepulveda, Stefano Serra, Chanjuan Shi, Xiaopu Yuan, Massimo Barberis, Roberto Bergamaschi, Arul M Chinnaiyan, Tony Detre, Shereen Ezzat, Andrea Frilling, Merten Hommann, Dirk Jaeger, Michelle K Kim, Beatrice S Knudsen, Andrew L Kung, Emer Leahy, David C Metz, Jeffrey W Milsom, Young S Park, Diane Reidy-Lagunes, Stuart Schreiber, Kay Washington, Bertram Wiedenmann, Irvin Modlin, Andrea Califano
We introduce and validate a new precision oncology framework for the systematic prioritization of drugs targeting mechanistic tumor dependencies in individual patients. Compounds are prioritized on the basis of their ability to invert the concerted activity of master regulator proteins that mechanistically regulate tumor cell state, as assessed from systematic drug perturbation assays. We validated the approach on a cohort of 212 gastroenteropancreatic neuroendocrine tumors (GEP-NETs), a rare malignancy originating in the pancreas and gastrointestinal tract...
June 18, 2018: Nature Genetics
https://www.readbyqxmd.com/read/29915086/accelerating-pathway-evolution-by-increasing-the-gene-dosage-of-chromosomal-segments
#6
Melissa Tumen-Velasquez, Christopher W Johnson, Alaa Ahmed, Graham Dominick, Emily M Fulk, Payal Khanna, Sarah A Lee, Alicia L Schmidt, Jeffrey G Linger, Mark A Eiteman, Gregg T Beckham, Ellen L Neidle
Experimental evolution is a critical tool in many disciplines, including metabolic engineering and synthetic biology. However, current methods rely on the chance occurrence of a key step that can dramatically accelerate evolution in natural systems, namely increased gene dosage. Our studies sought to induce the targeted amplification of chromosomal segments to facilitate rapid evolution. Since increased gene dosage confers novel phenotypes and genetic redundancy, we developed a method, Evolution by Amplification and Synthetic Biology (EASy), to create tandem arrays of chromosomal regions...
June 18, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29912415/primary-melanoma-histologic-subtype-impact-on-survival-and-response-to-therapy
#7
Michael Lattanzi, Yesung Lee, Danny Simpson, Una Moran, Farbod Darvishian, Randie H Kim, Eva Hernando, David Polsky, Doug Hanniford, Richard Shapiro, Russell Berman, Anna C Pavlick, Melissa A Wilson, Tomas Kirchhoff, Jeffrey S Weber, Judy Zhong, Iman Osman
Background: Two primary histologic subtypes, superficial spreading melanoma (SSM) and nodular melanoma (NM), comprise the majority of all cutaneous melanomas. NM is associated with worse outcomes, which have been attributed to increased thickness at presentation, and it is widely expected that NM and SSM would exhibit similar behavior once metastasized. Herein, we tested the hypothesis that primary histologic subtype is an independent predictor of survival and may impact response to treatment in the metastatic setting...
June 15, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29912393/a-plausibly-causal-functional-lupus-associated-risk-variant-in-the-stat1-stat4-locus
#8
Zubin Patel, Xiaoming Lu, Daniel Miller, Carmy R Forney, Joshua Lee, Arthur Lynch, Connor Schroeder, Lois Parks, Albert F Magnusen, Xiaoting Chen, Mario Pujato, Avery Maddox, Erin E Zoller, Bahram Namjou, Hermine I Brunner, Michael Henrickson, Jennifer L Huggins, Adrienne H Williams, Julie T Ziegler, Mary E Comeau, Miranda C Marion, Stuart B Glenn, Adam Adler, Nan Shen, Swapan K Nath, Anne M Stevens, Barry I Freedman, Bernardo A Pons-Estel, Betty P Tsao, Chaim O Jacob, Diane L Kamen, Elizabeth E Brown, Gary S Gilkeson, Graciela S Alarcón, Javier Martin, John D Reveille, Juan-Manuel Anaya, Judith A James, Kathy L Sivils, Lindsey A Criswell, Luis M Vilá, Michelle Petri, R Hal Scofield, Robert P Kimberly, Jeffrey C Edberg, Rosalind Ramsey-Goldman, So-Young Bang, Hye-Soon Lee, Sang-Cheol Bae, Susan A Boackle, Deborah Cunninghame Graham, Timothy J Vyse, Joan T Merrill, Timothy B Niewold, Hannah C Ainsworth, Earl D Silverman, Michael H Weisman, Daniel J Wallace, Prithvi Raj, Joel M Guthridge, Patrick M Gaffney, Jennifer A Kelly, Marta E Alarcón-Riquelme, Carl D Langefeld, Edward K Wakeland, Kenneth M Kaufman, Matthew T Weirauch, John B Harley, Leah C Kottyan
Systemic Lupus Erythematosus (SLE or lupus) (OMIM: 152700) is a chronic autoimmune disease with debilitating inflammation that affects multiple organ systems. The STAT1-STAT4 locus is one of the first and most highly-replicated genetic loci associated with lupus risk. We performed a fine-mapping study to identify plausible causal variants within the STAT1-STAT4 locus associated with increased lupus disease risk. Using complementary frequentist and Bayesian approaches in trans-ancestral Discovery and Replication cohorts, we found one variant whose association with lupus risk is supported across ancestries in both the Discovery and Replication cohorts: rs11889341...
April 18, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29906451/mfd-dynamically-regulates-transcription-via-a-release-and-catch-up-mechanism
#9
Tung T Le, Yi Yang, Chuang Tan, Margaret M Suhanovsky, Robert M Fulbright, James T Inman, Ming Li, Jaeyoon Lee, Sarah Perelman, Jeffrey W Roberts, Alexandra M Deaconescu, Michelle D Wang
No abstract text is available yet for this article.
June 14, 2018: Cell
https://www.readbyqxmd.com/read/29903030/diastolic-dysfunction-is-common-and-predicts-outcome-after-cardiac-surgery
#10
Thomas S Metkus, Alejandro Suarez-Pierre, Todd C Crawford, Jennifer S Lawton, Lee Goeddel, Jeffrey Dodd-O, Monica Mukherjee, Theodore P Abraham, Glenn J Whitman
BACKGROUND: Diastolic dysfunction (DD) identified on echocardiography predicts mortality after cardiac surgery, however the most useful diastolic parameters for assessment and the association of DD with prolonged mechanical ventilation, ICU re-admission, and hospital length of stay are not established. METHODS: We included patients that underwent coronary artery bypass grafting (CABG), aortic valve replacement (AVR) or a combined procedure (CAB-AVR) from 2010 to 2016, and who had preoperative transthoracic echocardiography (TTE) at our institution within 6 months of the operation...
June 15, 2018: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29901805/quantifying-contracture-severity-at-hospital-discharge-in-adults-a-burn-model-system-national-database-study
#11
Matthew Godleski, Austin F Lee, Jeremy Goverman, David N Herndon, Oscar E Suman, Karen J Kowalske, Radha K Holavanahalli, Nicole S Gibran, Peter C Esselman, Laura C Simko, Colleen M Ryan, Jeffrey C Schneider
Contracture is a common complication of burn injury and can cause significant barriers to functional recovery and rehabilitation. There are limited studies of quantitative range of motion after burn injury. The purpose of this study is to examine quantitative contracture outcomes by anatomical location, burn size, and length of stay in adults. Data were obtained from the Burn Model System National Database from 1994 to 2003. All adult patients with a joint contracture at acute discharge were included and 16 joint motions were examined...
June 13, 2018: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/29901795/the-effect-of-facial-burns-on-long-term-outcomes-in-young-adults-a-5-year-study
#12
Colleen M Ryan, Austin Lee, Frederick J Stoddard, Nien Chen Li, Jeffrey C Schneider, Gabriel D Shapiro, Cornelia L Griggs, Chao Wang, Tina Palmieri, Walter J Meyer, Frank S Pidcock, Debra Reilly, Robert L Sheridan, Lewis E Kazis, Ronald G Tompkins
Long-term functional outcomes in young adults with facial burns remain poorly studied. This 5-year (2003-2008) prospective multicenter study includes burn survivors (age 19-30 years) who completed the Young Adult Burn Outcome Questionnaire (YABOQ) from 0 to 36 months after baseline survey administration. A composite canonical score was developed from 15 YABOQ domains using discriminant analysis, maximizing the difference at the baseline between burn-injured patients with face involved and not involved. A generalized linear model with the generalized estimation equation technique was used to track the changing pattern of the composite score over time...
June 13, 2018: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/29899747/high-densities-of-tumor-associated-plasma-cells-predict-improved-prognosis-in-triple-negative-breast-cancer
#13
Joe Yeong, Jeffrey Chun Tatt Lim, Bernett Lee, Huihua Li, Noel Chia, Clara Chong Hui Ong, Weng Kit Lye, Thomas Choudary Putti, Rebecca Dent, Elaine Lim, Aye Aye Thike, Puay Hoon Tan, Jabed Iqbal
Breast cancer is the most common malignancy affecting women, but the heterogeneity of the condition is a significant obstacle to effective treatment. Triple negative breast cancers (TNBCs) do not express HER2 or the receptors for estrogen or progesterone, and so often have a poor prognosis. Tumor-infiltrating T cells have been well-characterized in TNBC, and increased numbers are associated with better outcomes; however, the potential roles of B cells and plasma cells have been large. Here, we conducted a retrospective correlative study on the expression of B cell/plasma cell-related genes, and the abundance and localization of B cells and plasma cells within TNBCs, and clinical outcome...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29899519/genetic-inactivation-of-angptl4-improves-glucose-homeostasis-and-is-associated-with-reduced-risk-of-diabetes
#14
Viktoria Gusarova, Colm O'Dushlaine, Tanya M Teslovich, Peter N Benotti, Tooraj Mirshahi, Omri Gottesman, Cristopher V Van Hout, Michael F Murray, Anubha Mahajan, Jonas B Nielsen, Lars Fritsche, Anders Berg Wulff, Daniel F Gudbjartsson, Marketa Sjögren, Connor A Emdin, Robert A Scott, Wen-Jane Lee, Aeron Small, Lydia C Kwee, Om Prakash Dwivedi, Rashmi B Prasad, Shannon Bruse, Alexander E Lopez, John Penn, Anthony Marcketta, Joseph B Leader, Christopher D Still, H Lester Kirchner, Uyenlinh L Mirshahi, Amr H Wardeh, Cassandra M Hartle, Lukas Habegger, Samantha N Fetterolf, Teresa Tusie-Luna, Andrew P Morris, Hilma Holm, Valgerdur Steinthorsdottir, Patrick Sulem, Unnur Thorsteinsdottir, Jerome I Rotter, Lee-Ming Chuang, Scott Damrauer, David Birtwell, Chad M Brummett, Amit V Khera, Pradeep Natarajan, Marju Orho-Melander, Jason Flannick, Luca A Lotta, Cristen J Willer, Oddgeir L Holmen, Marylyn D Ritchie, David H Ledbetter, Andrew J Murphy, Ingrid B Borecki, Jeffrey G Reid, John D Overton, Ola Hansson, Leif Groop, Svati H Shah, William E Kraus, Daniel J Rader, Yii-Der I Chen, Kristian Hveem, Nicholas J Wareham, Sekar Kathiresan, Olle Melander, Kari Stefansson, Børge G Nordestgaard, Anne Tybjærg-Hansen, Goncalo R Abecasis, David Altshuler, Jose C Florez, Michael Boehnke, Mark I McCarthy, George D Yancopoulos, David J Carey, Alan R Shuldiner, Aris Baras, Frederick E Dewey, Jesper Gromada
Angiopoietin-like 4 (ANGPTL4) is an endogenous inhibitor of lipoprotein lipase that modulates lipid levels, coronary atherosclerosis risk, and nutrient partitioning. We hypothesize that loss of ANGPTL4 function might improve glucose homeostasis and decrease risk of type 2 diabetes (T2D). We investigate protein-altering variants in ANGPTL4 among 58,124 participants in the DiscovEHR human genetics study, with follow-up studies in 82,766 T2D cases and 498,761 controls. Carriers of p.E40K, a variant that abolishes ANGPTL4 ability to inhibit lipoprotein lipase, have lower odds of T2D (odds ratio 0...
June 13, 2018: Nature Communications
https://www.readbyqxmd.com/read/29899441/author-correction-discovery-of-stimulation-responsive-immune-enhancers-with-crispr-activation
#15
Dimitre R Simeonov, Benjamin G Gowen, Mandy Boontanrart, Theodore L Roth, John D Gagnon, Maxwell R Mumbach, Ansuman T Satpathy, Youjin Lee, Nicolas L Bray, Alice Y Chan, Dmytro S Lituiev, Michelle L Nguyen, Rachel E Gate, Meena Subramaniam, Zhongmei Li, Jonathan M Woo, Therese Mitros, Graham J Ray, Gemma L Curie, Nicki Naddaf, Julia S Chu, Hong Ma, Eric Boyer, Frederic Van Gool, Hailiang Huang, Ruize Liu, Victoria R Tobin, Kathrin Schumann, Mark J Daly, Kyle K Farh, K Mark Ansel, Chun J Ye, William J Greenleaf, Mark S Anderson, Jeffrey A Bluestone, Howard Y Chang, Jacob E Corn, Alexander Marson
In this Letter, analysis of steady-state regulatory T (Treg) cell percentages from Il2ra enhancer deletion (EDEL) and wild-type (WT) mice revealed no differences between them (Extended Data Fig. 9d). This analysis included two mice whose genotypes were incorrectly assigned. Even after correction of the genotypes, no significant differences in Treg cell percentages were seen when data across experimental cohorts were averaged (as was done in Extended Data Fig. 9d). However, if we normalize the corrected data to account for variation among experimental cohorts, a subtle decrease in EDEL Treg cell percentages is revealed and, using the corrected and normalized data, we have redrawn Extended Data Fig...
June 13, 2018: Nature
https://www.readbyqxmd.com/read/29893274/a-prospective-phase-2-study-evaluating-safety-and-efficacy-of-combining-stereotactic-body-radiation-therapy-with-heat-based-ablation-for-centrally-located-lung-tumors
#16
Kiri A Sandler, Fereidoun Abtin, Robert Suh, Ryan R Cook, Carol Felix, Jay M Lee, Edward B Garon, Jeffrey Wu, Elaine M Luterstein, Nzhde Agazaryan, Stephen E Tenn, Chul Lee, Michael L Steinberg, Percy Lee
PURPOSE: Stereotactic body radiation therapy (SBRT) and heat-based ablation (HBA) are both potentially safe and effective treatments for primary and metastatic lung tumors. Both are suboptimal for centrally located tumors, with SBRT having a higher risk of significant toxicity and HBA having lower efficacy. This study evaluates the safety and efficacy of combination SBRT-HBA to determine whether combined treatment can result in superior outcomes to each treatment alone. METHODS AND MATERIALS: Patients with 1 or 2 primary or metastatic lung tumors ≤ 5 cm in size were enrolled in a prospective phase 2 trial and treated with SBRT in 3 fractions followed by HBA...
July 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29891893/therapeutic-luminal-coating-of-the-intestine
#17
Yuhan Lee, Tara E Deelman, Keyue Chen, Dawn S Y Lin, Ali Tavakkoli, Jeffrey M Karp
The gastrointestinal tract is the site of most drug delivery and therapeutic interventions for the management and treatment of numerous diseases. However, selective access to its mucosa, especially in the small bowel, is challenging. Here we develop an orally administered gut-coating formulation that provides a transient coating of the bowel. Through a materials screening campaign, we identified a sucrose octasulfate aluminium complex and further engineered the pH-dependent material into a complex coacervate formulation linked via pH-independent electrostatic interaction, which allowed an effective transient physical coating on the gastrointestinal mucosa, independent of gastric acid exposure...
June 11, 2018: Nature Materials
https://www.readbyqxmd.com/read/29891684/electron-hole-separation-in-ferroelectric-oxides-for-efficient-photovoltaic-responses
#18
Donghoon Kim, Hyeon Han, June Ho Lee, Jin Woo Choi, Jeffrey C Grossman, Hyun Myung Jang, Donghun Kim
Despite their potential to exceed the theoretical Shockley-Queisser limit, ferroelectric photovoltaics (FPVs) have performed inefficiently due to their extremely low photocurrents. Incorporating Bi2 FeCrO6 (BFCO) as the light absorber in FPVs has recently led to impressively high and record photocurrents [Nechache R, et al. (2015) Nat Photonics 9:61-67], which has revived the FPV field. However, our understanding of this remarkable phenomenon is far from satisfactory. Here, we use first-principles calculations to determine that such excellent performance mainly lies in the efficient separation of electron-hole ( e-h ) pairs...
June 11, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29891565/outcomes-in-mild-to-moderate-isolated-thrombocytopenia
#19
Charles Schlappi, Varsha Kulkarni, Prasannalaxmi Palabindela, Christina Bemrich-Stolz, Thomas Howard, Lee Hilliard, Jeffrey Lebensburger
OBJECTIVES: Incidental isolated mild to moderate thrombocytopenia is a frequent laboratory finding prompting a referral to pediatric hematology-oncology. We tested the hypothesis that patients with isolated asymptomatic mild thrombocytopenia would not progress to require an intervention from a pediatric hematologist-oncologist. METHODS: This is a 5-year retrospective review of 113 patients referred to pediatric hematology-oncology for isolated thrombocytopenia. Initial, lowest, and current platelet counts along with clinical course and need for interventions were recorded...
June 11, 2018: Pediatrics
https://www.readbyqxmd.com/read/29885373/bronchoscopic-and-electromagnetic-transthoracic-navigational-approaches-for-the-biopsy-of-peripheral-pulmonary-nodules
#20
Jeffrey Thiboutot, Hans J Lee, Gerard A Silvestri, Alex Chen, Momen M Wahidi, Christopher R Gilbert, Nicholas J Pastis, Jenna Los, Alexa M Barriere, Christopher Mallow, Benjamin Salwen, Marcus J Dinga, Eric L Flenaugh, Jason A Akulian, Roy Semaan, Lonny B Yarmus
BACKGROUND: Pulmonary nodules are a common but difficult issue for physicians as most identified on imaging are benign but those identified early that are cancerous are potentially curable. Multiple diagnostic options are available, ranging from radiographic surveillance, minimally invasive biopsy (bronchoscopy or transthoracic biopsy) to more invasive surgical biopsy/resection. Each technique has differences in diagnostic yield and complication rates with no established gold standard...
June 6, 2018: Contemporary Clinical Trials
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