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Jeffrey lee

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https://www.readbyqxmd.com/read/28819565/genomic-and-immune-heterogeneity-are-associated-with-differential-responses-to-therapy-in-melanoma
#1
Alexandre Reuben, Christine N Spencer, Peter A Prieto, Vancheswaran Gopalakrishnan, Sangeetha M Reddy, John P Miller, Xizeng Mao, Mariana Petaccia De Macedo, Jiong Chen, Xingzhi Song, Hong Jiang, Pei-Ling Chen, Hannah C Beird, Haven R Garber, Whijae Roh, Khalida Wani, Eveline Chen, Cara Haymaker, Marie-Andrée Forget, Latasha D Little, Curtis Gumbs, Rebecca L Thornton, Courtney W Hudgens, Wei-Shen Chen, Jacob Austin-Breneman, Robert Szczepaniak Sloane, Luigi Nezi, Alexandria P Cogdill, Chantale Bernatchez, Jason Roszik, Patrick Hwu, Scott E Woodman, Lynda Chin, Hussein Tawbi, Michael A Davies, Jeffrey E Gershenwald, Rodabe N Amaria, Isabella C Glitza, Adi Diab, Sapna P Patel, Jianhua Hu, Jeffrey E Lee, Elizabeth A Grimm, Michael T Tetzlaff, Alexander J Lazar, Ignacio I Wistuba, Karen Clise-Dwyer, Brett W Carter, Jianhua Zhang, P Andrew Futreal, Padmanee Sharma, James P Allison, Zachary A Cooper, Jennifer A Wargo
Appreciation for genomic and immune heterogeneity in cancer has grown though the relationship of these factors to treatment response has not been thoroughly elucidated. To better understand this, we studied a large cohort of melanoma patients treated with targeted therapy or immune checkpoint blockade (n = 60). Heterogeneity in therapeutic responses via radiologic assessment was observed in the majority of patients. Synchronous melanoma metastases were analyzed via deep genomic and immune profiling, and revealed substantial genomic and immune heterogeneity in all patients studied, with considerable diversity in T cell frequency, and few shared T cell clones (<8% on average) across the cohort...
2017: NPJ Genomic Medicine
https://www.readbyqxmd.com/read/28817384/engineering-the-mechanical-and-biological-properties-of-nanofibrous-vascular-grafts-for-in-situ-vascular-tissue-engineering
#2
Jeffrey J D Henry, Jian Yu, Aijun Wang, Randall Lee, Jun Fang, Song Li
Synthetic small diameter vascular grafts have a high failure rate, and endothelialization is critical for preventing thrombosis and graft occlusion. A promising approach is in situ tissue engineering, whereby an acellular scaffold is implanted and provides stimulatory cues to guide the in situ remodeling into a functional blood vessel. An ideal scaffold should have sufficient binding sites for biomolecule immobilization and a mechanical property similar to native tissue. Here we developed a novel method to blend low molecular weight (LMW) elastic polymer during electrospinning process to increase conjugation sites and to improve the mechanical property of vascular grafts...
August 17, 2017: Biofabrication
https://www.readbyqxmd.com/read/28816494/gaming-disorder-its-delineation-as-an-important-condition-for-diagnosis-management-and-prevention
#3
John B Saunders, Wei Hao, Jiang Long, Daniel L King, Karl Mann, Mira Fauth-Bühler, Hans-Jürgen Rumpf, Henrietta Bowden-Jones, Afarin Rahimi-Movaghar, Thomas Chung, Elda Chan, Norharlina Bahar, Sophia Achab, Hae Kook Lee, Marc Potenza, Nancy Petry, Daniel Spritzer, Atul Ambekar, Jeffrey Derevensky, Mark D Griffiths, Halley M Pontes, Daria Kuss, Susumu Higuchi, Satoko Mihara, Sawitri Assangangkornchai, Manoj Sharma, Ahmad El Kashef, Patrick Ip, Michael Farrell, Emanuele Scafato, Natacha Carragher, Vladimir Poznyak
Online gaming has greatly increased in popularity in recent years, and with this has come a multiplicity of problems due to excessive involvement in gaming. Gaming disorder, both online and offline, has been defined for the first time in the draft of 11th revision of the International Classification of Diseases (ICD-11). National surveys have shown prevalence rates of gaming disorder/addiction of 10%-15% among young people in several Asian countries and of 1%-10% in their counterparts in some Western countries...
August 17, 2017: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/28813585/association-of-general-surgery-resident-remediation-and-program-director-attitudes-with-resident-attrition
#4
Alexander C Schwed, Steven L Lee, Edgardo S Salcedo, Mark E Reeves, Kenji Inaba, Richard A Sidwell, Farin Amersi, Chandrakanth Are, Tracey D Arnell, Richard B Damewood, Daniel L Dent, Timothy Donahue, Jeffrey Gauvin, Thomas Hartranft, Garth R Jacobsen, Benjamin T Jarman, Marc L Melcher, John D Mellinger, Jon B Morris, Mark Nehler, Brian R Smith, Mary Wolfe, Amy H Kaji, Christian de Virgilio
Importance: Previous studies of resident attrition have variably included preliminary residents and likely overestimated categorical resident attrition. Whether program director attitudes affect attrition has been unclear. Objectives: To determine whether program director attitudes are associated with resident attrition and to measure the categorical resident attrition rate. Design, Setting, and Participants: This multicenter study surveyed 21 US program directors in general surgery about their opinions regarding resident education and attrition...
August 16, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28805827/transcriptional-risk-scores-link-gwas-to-eqtls-and-predict-complications-in-crohn-s-disease
#5
Urko M Marigorta, Lee A Denson, Jeffrey S Hyams, Kajari Mondal, Jarod Prince, Thomas D Walters, Anne Griffiths, Joshua D Noe, Wallace V Crandall, Joel R Rosh, David R Mack, Richard Kellermayer, Melvin B Heyman, Susan S Baker, Michael C Stephens, Robert N Baldassano, James F Markowitz, Mi-Ok Kim, Marla C Dubinsky, Judy Cho, Bruce J Aronow, Subra Kugathasan, Greg Gibson
Gene expression profiling can be used to uncover the mechanisms by which loci identified through genome-wide association studies (GWAS) contribute to pathology. Given that most GWAS hits are in putative regulatory regions and transcript abundance is physiologically closer to the phenotype of interest, we hypothesized that summation of risk-allele-associated gene expression, namely a transcriptional risk score (TRS), should provide accurate estimates of disease risk. We integrate summary-level GWAS and expression quantitative trait locus (eQTL) data with RNA-seq data from the RISK study, an inception cohort of pediatric Crohn's disease...
August 14, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28802530/report-of-the-international-society-for-heart-and-lung-transplantation-working-group-on-primary-lung-graft-dysfunction-part-ii-epidemiology-risk-factors-and-outcomes-a-2016-consensus-group-statement-of-the-international-society-for-heart-and-lung-transplantation
#6
EDITORIAL
Joshua M Diamond, Selim Arcasoy, Cassie C Kennedy, Michael Eberlein, Jonathan P Singer, Glenda M Patterson, Jeffrey D Edelman, Gundeep Dhillon, Tahuanty Pena, Steven M Kawut, James C Lee, Reda Girgis, John Dark, Gabriel Thabut
No abstract text is available yet for this article.
July 26, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28797605/space-available-for-cord-motion-and-disc-degeneration-at-the-adjacent-segments-level-of-degenerative-cervical-spondylolisthesis-using-kinematic-mri
#7
Permsak Paholpak, Alexander Nazareth, Kaku Barkoh, Larry V Lee, Joshua Lucas, Zorica Buser, Jeffrey C Wang
The objective was to evaluate motion, disc degeneration and Space Available for Cord (SAC) at the adjacent segments of degenerative cervical spondylolisthesis (DCS) using kinematic Magnetic Resonance Imaging (kMRI). The cervical spine kMRI of sixty-one DCS spinal levels (38 anterolisthesis and 23 retrolisthesis) were analyzed at the listhesis level and its adjacent segments in three position using kMRI. MRAnalyzer3 was used to analyze translation, angular motion and SAC. The caudad level had significantly less translation motion than the listhesis level in overall DCS or grade 2 anterolisthesis group (P<0...
August 7, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28796414/genetic-variants-in-the-metzincin-metallopeptidase-family-genes-predict-melanoma-survival
#8
Yinghui Xu, Yanru Wang, Hongliang Liu, Qiong Shi, Dakai Zhu, Christopher I Amos, Shenying Fang, Jeffrey E Lee, Terry Hyslop, Xin Li, Jiali Han, Qingyi Wei
Metzincins are key molecules in the degradation of the extracellular matrix and play an important role in cellular processes such as cell migration, adhesion, and cell fusion of malignant tumors, including cutaneous melanoma (CM). We hypothesized that genetic variants of the metzincin metallopeptidase family genes would be associated with CM-specific survival (CMSS). To test this hypothesis, we first performed Cox proportional hazards regression analysis to evaluate the associations between genetic variants of 75 metzincin metallopeptidase family genes and CMSS using the dataset from the genome-wide association study (GWAS) from The University of Texas MD Anderson cancer Center (MDACC) which included 858 non-Hispanic white patients with CM, and then validated in the dataset from the Harvard GWAS study which had 409 non-Hispanic white patients with invasive CM...
August 10, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28794282/partial-efficacy-of-a-broadly-neutralizing-antibody-against-cell-associated-shiv-infection
#9
Matthew S Parsons, Sarah B Lloyd, Wen Shi Lee, Anne B Kristensen, Thakshila Amarasena, Rob J Center, Brandon F Keele, Jeffrey D Lifson, Celia C LaBranche, David Montefiori, Bruce D Wines, P Mark Hogarth, Kristine M Swiderek, Vanessa Venturi, Miles P Davenport, Stephen J Kent
Broadly neutralizing antibodies (BnAbs) protect macaques from cell-free simian/human immunodeficiency virus (SHIV) challenge, but their efficacy against cell-associated SHIV is unclear. Virus in cell-associated format is highly infectious, present in transmission-competent bodily fluids, and potentially capable of evading antibody-mediated neutralization. The PGT121 BnAb, which recognizes an epitope consisting of the V3 loop and envelope glycans, mediates antibody-dependent cellular cytotoxicity and neutralization of cell-to-cell HIV-1 transmission...
August 9, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28792760/structural-basis-of-wee-kinases-functionality-and-inactivation-by-diverse-small-molecule-inhibitors
#10
Jin-Yi Zhu, Rebecca Ann Duenes Cuellar, Norbert Berndt, Hee Eun Lee, Sanne H Olesen, Mathew P Martin, Jeffrey T Jensen, Gunda I Georg, Ernst Schönbrunn
Members of the Wee family of kinases negatively regulate the cell cycle via phosphorylation of CDK1 and are considered potential drug targets. Herein, we investigated the structure-function relationship of human Wee1, Wee2 and Myt1 (PKMYT1). Purified recombinant full-length proteins and kinase domain constructs differed substantially in phosphorylation states and catalytic competency suggesting complex mechanisms of activation. A series of crystal structures revealed unique features that distinguish Wee1 and Wee2 from Myt1 and establish the structural basis of differential inhibition by the widely used Wee1 inhibitor MK-1775...
August 9, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28783698/maintenance-of-macrophage-transcriptional-programs-and-intestinal-homeostasis-by-epigenetic-reader-sp140
#11
Stuti Mehta, D Alexander Cronkite, Megha Basavappa, Tahnee L Saunders, Fatemeh Adiliaghdam, Hajera Amatullah, Sara A Morrison, Jose D Pagan, Robert M Anthony, Pierre Tonnerre, Georg M Lauer, James C Lee, Sreehaas Digumarthi, Lorena Pantano, Shannan J Ho Sui, Fei Ji, Ruslan Sadreyev, Chan Zhou, Alan C Mullen, Vinod Kumar, Yang Li, Cisca Wijmenga, Ramnik J Xavier, Terry K Means, Kate L Jeffrey
Epigenetic "readers" that recognize defined posttranslational modifications on histones have become desirable therapeutic targets for cancer and inflammation. SP140 is one such bromodomain- and plant homeodomain (PHD)-containing reader with immune-restricted expression, and single-nucleotide polymorphisms (SNPs) within SP140 associate with Crohn's disease (CD). However, the function of SP140 and the consequences of disease-associated SP140 SNPs have remained unclear. We show that SP140 is critical for transcriptional programs that uphold the macrophage state...
March 3, 2017: Science Immunology
https://www.readbyqxmd.com/read/28768645/utilization-of-statins-beyond-the-initial-period-after-stroke-and-1-year-risk-of-recurrent-stroke
#12
Meng Lee, Jeffrey L Saver, Yi-Ling Wu, Sung-Chun Tang, Jiann-Der Lee, Neal M Rao, Hui-Hsuan Wang, Jiann-Shing Jeng, Tsong-Hai Lee, Pei-Chun Chen, Bruce Ovbiagele
BACKGROUND: In-hospital discontinuation of statins has been linked to poorer early stroke outcomes, but the consequences of postdischarge discontinuation or dose reduction of statin treatment are unknown. The objective of this study was to explore the effects of statin discontinuation or statin dose reduction on recurrent stroke risk. METHODS AND RESULTS: We conducted a nationwide cohort study using the data from the Taiwan National Health Insurance Research Database...
August 2, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28765700/endoscopy-is-of-low-yield-in-the-identification-of-gastrointestinal-neoplasia-in-patients-with-dermatomyositis-a-cross-sectional-study
#13
Trilokesh D Kidambi, Gabriela Schmajuk, Andrew J Gross, James W Ostroff, Jonathan P Terdiman, Jeffrey K Lee
AIM: To determine the prevalence of gastrointestinal neoplasia among dermatomyositis patients who underwent an esophagogastroduodenoscopy and/or colonoscopy. METHODS: A cross-sectional study examining the results of upper endoscopy and colonoscopy in adults with dermatomyositis at an urban, university hospital over a ten year period was performed. Chart review was performed to confirm the diagnosis of dermatomyositis. Findings on endoscopy were collected and statistical analyses stratified by age and presence of symptoms were performed...
July 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28763325/could-activity-modifications-indicate-physical-decline-among-adults-with-symptomatic-knee-osteoarthritis
#14
Augustine C Lee, Rina M Bloch, William F Harvey, Jeffrey B Driban, Lori Lyn Price, Xingyi Han, Chenchen Wang
OBJECTIVES: Mobility activity modifications indicate early functional losses that act as precursors to future declines among community-dwelling older adults. However, there is scarce evidence on whether activity modifications indicate poorer physical health among adults with symptomatic osteoarthritis, a major cause of disability. Our purpose was to investigate whether patient-reported mobility activity modifications indicated poorer physical health among adults with symptomatic knee osteoarthritis...
August 1, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28761916/re-an-unusual-migratory-polycyclic-eruption-after-administration-of-prostaglandin-e-in-a-neonate
#15
Lee Wheless, Laura E Murray, Fariha Siddiqui, Jeffrey D Byers
No abstract text is available yet for this article.
July 2017: JAAD Case Reports
https://www.readbyqxmd.com/read/28760988/ultralow-thermal-conductivity-in-all-inorganic-halide-perovskites
#16
Woochul Lee, Huashan Li, Andrew B Wong, Dandan Zhang, Minliang Lai, Yi Yu, Qiao Kong, Elbert Lin, Jeffrey J Urban, Jeffrey C Grossman, Peidong Yang
Controlling the flow of thermal energy is crucial to numerous applications ranging from microelectronic devices to energy storage and energy conversion devices. Here, we report ultralow lattice thermal conductivities of solution-synthesized, single-crystalline all-inorganic halide perovskite nanowires composed of CsPbI3 (0.45 ± 0.05 W·m(-1)·K(-1)), CsPbBr3 (0.42 ± 0.04 W·m(-1)·K(-1)), and CsSnI3 (0.38 ± 0.04 W·m(-1)·K(-1)). We attribute this ultralow thermal conductivity to the cluster rattling mechanism, wherein strong optical-acoustic phonon scatterings are driven by a mixture of 0D/1D/2D collective motions...
August 15, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28756872/retinoic-acid-improves-nephrotoxic-serum-induced-glomerulonephritis-through-activation-of-podocyte-retinoic-acid-receptor-%C3%AE
#17
Yan Dai, Anqun Chen, Ruijie Liu, Leyi Gu, Shuchita Sharma, Weijing Cai, Fadi Salem, David J Salant, Jeffrey W Pippin, Stuart J Shankland, Marcus J Moeller, Norbert B Ghyselinck, Xiaquiang Ding, Peter Y Chuang, Kyung Lee, John Cijiang He
Proliferation of glomerular epithelial cells, including podocytes, is a key histologic feature of crescentic glomerulonephritis. We previously found that retinoic acid (RA) inhibits proliferation and induces differentiation of podocytes by activating RA receptor-α (RARα) in a murine model of HIV-associated nephropathy. Here, we examined whether RA would similarly protect podocytes against nephrotoxic serum-induced crescentic glomerulonephritis and whether this effect was mediated by podocyte RARα. RA treatment markedly improved renal function and reduced the number of crescentic lesions in nephritic wild-type mice, while this protection was largely lost in mice with podocyte-specific ablation of Rara (Pod-Rara knockout)...
July 27, 2017: Kidney International
https://www.readbyqxmd.com/read/28753826/programmed-death-ligand-1-expression-in-upper-tract-urothelial-carcinoma
#18
Stephanie L Skala, Tzu-Ying Liu, Aaron M Udager, Alon Z Weizer, Jeffrey S Montgomery, Ganesh S Palapattu, Javed Siddiqui, Xuhong Cao, Kristina Fields, Ahmed E Abugharib, Moaaz Soliman, Khaled S Hafez, David Miller, Cheryl T Lee, Ajjai Alva, Arul M Chinnaiyan, Todd M Morgan, Daniel E Spratt, Hui Jiang, Rohit Mehra
BACKGROUND: Urothelial carcinoma (UC) is the most common malignancy of the urinary tract. Upper tract (renal pelvis and ureter) urothelial carcinomas (UTUC) account for approximately 5% of UCs but a significant subset are invasive and associated with poor clinical outcomes. OBJECTIVE: To evaluate programmed death-ligand 1 (PD-L1) expression in UTUC. DESIGN, SETTING, AND PARTICIPANTS: UTUC cases from 1997-2016 were retrospectively identified from the surgical pathology database at a single large academic institution...
December 13, 2016: European Urology Focus
https://www.readbyqxmd.com/read/28753778/the-fate-of-radical-cystectomy-patients-after-hospital-discharge-understanding-the-black-box-of-the-pre-readmission-interval
#19
Naveen Krishnan, Benjamin Li, Bruce L Jacobs, Sapan N Ambani, Tudor Borza, Chang He, Brent K Hollenbeck, Todd Morgan, Khaled S Hafez, Alon Z Weizer, Jeffrey S Montgomery, Cheryl T Lee, Opal Lesse, Mariel S Lavieri, Jonathan E Helm, Ted A Skolarus
BACKGROUND: Radical cystectomy has one of the highest 30-d hospital readmission rates but circumstances leading to readmission remain poorly understood. OBJECTIVE: To examine the postdischarge period and better understand hospital readmission after radical cystectomy. DESIGN, SETTING, AND PARTICIPANTS: We conducted a retrospective cohort study of patients treated with radical cystectomy for bladder cancer from 2005 to 2012 using our institutional database...
August 4, 2016: European Urology Focus
https://www.readbyqxmd.com/read/28753178/caesarean-section-on-the-risk-of-celiac-disease-in-the-offspring-the-teddy-study
#20
Sibylle Koletzko, Hye-Seung Lee, Andreas Beyerlein, Carin A Aronsson, Michael Hummel, Edwin Liu, Ville Simell, Kalle Kurppa, Åke Lernmark, William Hagopian, Marian Rewers, Jin-Xiong She, Olli Simell, Jorma Toppari, Anette-G Ziegler, Jeffrey Krischer, Daniel Agardh
OBJECTIVE: Caesarean section (C-section) is associated with various immune-mediated diseases in the offspring. We investigated the relationship between mode of delivery and celiac disease (CD) and CD autoimmunity (CDA) in a multinational birth cohort. METHODS: From 2004 to 2010 infants from the general population who tested positive for HLA DR3-DQ2 or DR4-DQ8 were enrolled in The Environmental Determinants for Diabetes in the Young (TEDDY) study. Children were annually screened for transglutaminase autoantibodies, if positive re-tested after 3-6 months and those persistently positive defined as CDA...
July 27, 2017: Journal of Pediatric Gastroenterology and Nutrition
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