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Jeffrey lee

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https://www.readbyqxmd.com/read/28430642/immunocompetent-mouse-allograft-models-for-development-of-therapies-to-target-breast-cancer-metastasis
#1
Yuan Yang, Howard H Yang, Ying Hu, Peter H Watson, Huaitian Liu, Thomas R Geiger, Miriam R Anver, Diana C Haines, Philip Martin, Jeffrey E Green, Maxwell P Lee, Kent W Hunter, Lalage M Wakefield
Effective drug development to combat metastatic disease in breast cancer would be aided by the availability of well-characterized preclinical animal models that (a) metastasize with high efficiency, (b) metastasize in a reasonable time-frame, (c) have an intact immune system, and (d) capture some of the heterogeneity of the human disease. To address these issues, we have assembled a panel of twelve mouse mammary cancer cell lines that can metastasize efficiently on implantation into syngeneic immunocompetent hosts...
February 25, 2017: Oncotarget
https://www.readbyqxmd.com/read/28429499/atrial-fibrillation-patients-with-isolated-pulmonary-veins-is-sinus-rhythm-achievable
#2
Judit Szilágyi, Gregory M Marcus, Nitish Badhwar, Byron K Lee, Randall J Lee, Vasanth Vedantham, Zian H Tseng, Tomos Walters, Melvin Scheinman, Jeffrey Olgin, Edward P Gerstenfeld
BACKGROUND: The cornerstone of atrial fibrillation (AF) ablation is isolation of the pulmonary veins (PVs). Patients with recurrent AF undergoing repeat ablation usually have PV reconnection (PVr). The ablation strategy and outcome of patients undergoing repeat ablation who have persistent isolation of all PVs (PVi) at the time of repeat ablation is unknown. METHODS AND RESULTS: We studied consecutive patients with recurrent AF undergoing repeat ablation and compared patients with PVi to those with PVr...
April 21, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28427885/prognostic-scoring-system-to-risk-stratify-parathyroid-carcinoma
#3
Angelica M Silva-Figueroa, Kenneth R Hess, Michelle D Williams, Callisia N Clarke, Ioannis Christakis, Paul H Graham, Elizabeth G Grubbs, Jeffrey E Lee, Naifa L Busaidy, Nancy D Perrier
BACKGROUND: Parathyroid carcinoma is a rare endocrine malignancy that lacks an established system for risk categorization. This study evaluated a prognostic scoring system for recurrence-free survival (RFS) of patients with parathyroid carcinoma. STUDY DESIGN: Patients diagnosed and confirmed to have parathyroid carcinoma and who were treated between 1980 and 2016 at The University of Texas MD Anderson Cancer Center were studied retrospectively. Univariate and multivariate Cox proportional hazards regression analyses of RFS were conducted...
March 15, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28426890/fine-mapping-of-lipid-regions-in-global-populations-discovers-ethnic-specific-signals-and-refines-previously-identified-lipid-loci
#4
Niha Zubair, Mariaelisa Graff, Jose Luis Ambite, William S Bush, Gleb Kichaev, Yingchang Lu, Ani Manichaikul, Wayne H-H Sheu, Devin Absher, Themistocles L Assimes, Suzette J Bielinski, Erwin P Bottinger, Petra Buzkova, Lee-Ming Chuang, Ren-Hua Chung, Barbara Cochran, Logan Dumitrescu, Omri Gottesman, Jeffrey W Haessler, Christopher Haiman, Gerardo Heiss, Chao A Hsiung, Yi-Jen Hung, Chii-Min Hwu, Jyh-Ming J Juang, Loic Le Marchand, I-Te Lee, Wen-Jane Lee, Li-An Lin, Danyu Lin, Shih-Yi Lin, Rachel H Mackey, Lisa W Martin, Bogdan Pasaniuc, Ulrike Peters, Irene Predazzi, Thomas Quertermous, Alex P Reiner, Jennifer Robinson, Jerome I Rotter, Kelli K Ryckman, Pamela J Schreiner, Eli Stahl, Ran Tao, Michael Y Tsai, Lindsay L Waite, Tzung-Dau Wang, Steven Buyske, Yii-Der Ida Chen, Iona Cheng, Dana C Crawford, Ruth J F Loos, Stephen S Rich, Myriam Fornage, Kari E North, Charles Kooperberg, Cara L Carty
Genome-wide association studies have identified over 150 loci associated with lipid traits, however, no large-scale studies exist for Hispanics and other minority populations. Additionally, the genetic architecture of lipid-influencing loci remains largely unknown. We performed one of the most racially/ethnically diverse fine-mapping genetic studies of HDL-C, LDL-C, and triglycerides to-date using SNPs on the MetaboChip array on 54,119 individuals: 21,304 African Americans, 19,829 Hispanic Americans, 12,456 Asians, and 530 American Indians...
December 15, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/28424286/subtype-specific-differences-in-gag-protease-driven-replication-capacity-are-consistent-with-inter-subtype-differences-in-hiv-1-disease-progression
#5
Marion W Kiguoya, Jaclyn K Mann, Denis Chopera, Kamini Gounder, Guinevere Q Lee, Peter W Hunt, Jeffrey N Martin, T Blake Ball, Joshua Kimani, Zabrina L Brumme, Mark A Brockman, Thumbi Ndung'u
There are marked differences in the spread and prevalence of HIV-1 subtypes worldwide, and differences in clinical progression have been reported. However, the biological reasons underlying these differences are unknown. Gag-protease is essential for HIV-1 replication and Gag-protease-driven replication capacity has previously been correlated with disease progression. We show that Gag-protease replication capacity correlates significantly with that of whole isolates (r=0.51; p=0.04), indicating that Gag-protease is a significant contributor to viral replication capacity...
April 19, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28417239/incidental-gallbladder-cancer-residual-cancer-discovered-at-oncologic-extended-resection-determines-outcome-a-report-from-high-and-low-incidence-countries
#6
Eduardo Vinuela, Eduardo A Vega, Suguru Yamashita, Marcel Sanhueza, Rosemarie Mege, Gabriel Cavada, Thomas A Aloia, Yun Shin Chun, Jeffrey E Lee, Jean-Nicolas Vauthey, Claudius Conrad
BACKGROUND: Gallbladder cancer detected incidentally after cholecystectomy (IGBC) currently is the most common diagnosis of gallbladder cancer, and oncologic extended resection (OER) is recommended for tumors classified higher than T1b. However, the precise prognostic significance of residual cancer (RC) found at the time of OER has not been well established. This analysis aimed to determine the prognostic impact of RC found in patients with IGBC undergoing OER. METHODS: Outcomes for IGBC at a center for a low-incidence country (USA) and a high-incidence country (Chile) between January 1999 and June 2015 were analyzed...
April 17, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28416247/adaptive-crt-in-patients-with-normal-av-conduction-and-left-bundle-branch-block-does-qrs-duration-matter
#7
Hiro Yamasaki, Daniel Lustgarten, Jeffrey Cerkvenik, David Birnie, Maurizio Gasparini, Kathy Lia-Fun Lee, Yukio Sekiguchi, Niraj Varma, Bernd Lemke, Randall C Starling, Kazutaka Aonuma
BACKGROUND: Adaptive cardiac resynchronization therapy (aCRT) is a dynamic optimization algorithm which paces only the left ventricle (LV) when atrio-ventricular (AV) conduction is normal, thus reducing right ventricular (RV) pacing. However, the impact of QRS duration on aCRT efficacy remains uncertain. We examined whether QRS duration impacts aCRT effectiveness in patients with left bundle branch block (LBBB) and preserved AV conduction. METHODS: Randomized patients in the Adaptive CRT trial, which enrolled NYHA III/IV patients, were used in this analysis...
April 12, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28414524/a-standardized-diagnostic-ontology-for-fibrotic-interstitial-lung-disease-an-international-working-group-perspective
#8
Christopher J Ryerson, Tamera J Corte, Joyce S Lee, Luca Richeldi, Simon L F Walsh, Jeffrey L Myers, Juergen Behr, Vincent Cottin, Sonye K Danoff, Kevin R Flaherty, David J Lederer, David A Lynch, Fernando J Martinez, Ganesh Raghu, William D Travis, Zarir Udwadia, Athol U Wells, Harold R Collard
Diagnosing fibrotic interstitial lung disease (ILD) requires multidisciplinary integration of clinical, radiological, and pathological features with assignment of a consensus classification. The current approach lacks a standardized ontology and therefore results in diagnostic heterogeneity. The objectives of this international working group perspective are to describe limitations of the current approach to fibrotic ILD diagnosis and to develop an ontological framework for standardizing the diagnostic classification...
April 17, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28410653/ensuring-patient-safety-during-the-transition-to-esrd
#9
REVIEW
Lee-Ann Wagner, Jeffrey C Fink
Patients with chronic kidney disease (CKD) are at risk for complications both inherent to the disease and as a consequence of its treatment. The dangers that CKD patients face change across the spectrum of the disease. Providers who are well-versed in these safety threats are best poised to safeguard patients as their CKD progresses.
March 2017: Seminars in Nephrology
https://www.readbyqxmd.com/read/28408934/sdf-1-cxcr4-signaling-maintains-stemness-signature-in-mouse-neural-stem-progenitor-cells
#10
Shih-Yin Ho, Thai-Yen Ling, Hsing-Yu Lin, Jeffrey Tsai-Jui Liou, Fei-Chih Liu, I-Chun Chen, Sue-Wei Lee, Yu Hsu, Dar-Ming Lai, Horng-Huei Liou
SDF-1 and its primary receptor, CXCR4, are highly expressed in the embryonic central nervous system (CNS) and play a crucial role in brain architecture. Loss of SDF-1/CXCR4 signaling causes abnormal development of neural stem/progenitor cells (NSCs/NPCs) in the cerebellum, hippocampus, and cortex. However, the mechanism of SDF-1/CXCR4 axis in NSCs/NPCs regulation remains unknown. In this study, we found that elimination of SDF-1/CXCR4 transduction caused NSCs/NPCs to lose their stemness characteristics and to encounter neurogenic differentiation...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28408615/phase-ii-study-of-bortezomib-in-combination-with-cyclophosphamide-and-rituximab-for-relapsed-or-refractory-mantle-cell-lymphoma
#11
Hun Ju Lee, Jorge E Romaguera, Lei Feng, Aakash P Desai, Liang Zhang, Michelle Fanale, Felipe Samaniego, Fredrick B Hagemeister, Luis E Fayad, Maria A Rodriguez, Jeffrey L Medeiros, Kimberly Hartig, Krystle Nomie, Makhdum Ahmed, Maria Badillo, Haige Ye, Yasuhiro Oki, Pei Lin, Loretta Nastoupil, Jason Westin, Michael Wang
BACKGROUND: Relapsed or refractory mantle cell lymphoma (MCL) has a poor prognosis. The best outcome is achieved in patients who have a partial or complete response to salvage treatment and proceed to allogeneic stem cell transplant. PATIENTS AND METHODS: Twenty-one patients were given a combination regimen of bortezomib, cyclophosphamide, and rituximab at MD Anderson Cancer Center as part of a single-arm, prospective, open-label phase II clinical trial. The median age was 66 years, with a median number of prior treatments of three...
April 13, 2017: Oncologist
https://www.readbyqxmd.com/read/28403030/keep-screening-maternal-gonococcal-infection-and-adverse-birth-outcomes
#12
Chelsea Lee Shannon, Jeffrey D Klausner
No abstract text is available yet for this article.
May 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28401476/robotic-buccal-ureteroplasty-a-review-of-the-current-literature
#13
REVIEW
Benjamin Waldorf, Ziho Lee, Laura Kidd, Joshua Kaplan, Andrew Harris, Michael Metro, Jeffrey Liu, Daniel Eun
PURPOSE OF REVIEW: This study aimed to provide an overview of the literature on buccal mucosal ureteroplasty for ureteral stricture disease, with a specific focus on the application of the robotic platform to buccal ureteroplasty. RECENT FINDINGS: In our review, we highlight the results of Zhao et al. from the New York University School of Medicine Department of Urology, as well as our own results from Temple University Hospital. Zhao et al. published the first series of four patients who underwent robotic buccal ureteroplasty...
May 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28399218/timed-up-and-go-predicts-functional-decline-in-older-patients-presenting-to-the-emergency-department-following-minor-trauma%C3%A2
#14
Debra Eagles, Jeffrey J Perry, Marie-Josée Sirois, Eddy Lang, Raoul Daoust, Jacques Lee, Lauren Griffith, Laura Wilding, Xavier Neveu, Marcel Emond
Background: there is no standardised test for assessing mobility in the Emergency Department (ED). Objective: we wished to evaluate the relationship between the Timed Up and Go (TUG) and frailty, functional decline and falls in community dwelling elders that present to the ED following minor trauma. Methods: this was a secondary analysis of a prospective cohort study conducted at eight Canadian hospitals. Evaluations included: TUG; Study of Osteoporotic Fractures Frailty Index; Older American Resources and Service Functional Scale; and self-reported falls...
March 1, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28399116/maternal-pre-pregnancy-body-mass-index-and-risk-of-bronchopulmonary-dysplasia
#15
Suzan L Carmichael, Peiyi Kan, Jeffrey B Gould, David K Stevenson, Gary M Shaw, Henry C Lee
BACKGROUND: We examined the relationship between women's prepregnancy body mass index (BMI) and development of bronchopulmonary dysplasia (BPD) in their preterm offspring, hypothesizing that obesity-associated inflammation may increase risk. METHODS: We studied infants born in California 2007-2011, using linked data from California Perinatal Quality Care Collaborative neonatal intensive care units, hospital discharge, and vital statistics. We included infants with birthweight<1500 grams or gestational age at birth 22-29 weeks...
April 11, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28397396/insight-gained-from-responses-to-surveys-on-reference-dosimetry-practices
#16
Bryan Muir, Wesley Culberson, Stephen Davis, Gwe-Ya Kim, Yimei Huang, Sung-Woo Lee, Jessica Lowenstein, Arman Sarfehnia, Jeffrey Siebers, Naresh Tolani
PURPOSE: To present the results and discuss potential insights gained through surveys on reference dosimetry practices. METHODS: Two surveys were sent to medical physicists to learn about the current state of reference dosimetry practices at radiation oncology clinics worldwide. A short survey designed to maximize response rate was made publicly available and distributed via the AAPM website and a medical physics list server. Another, much more involved survey, was sent to a smaller group of physicists to gain insight on detailed dosimetry practices...
April 11, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28391526/trans-ethnic-fine-mapping-of-genetic-loci-for-body-mass-index-in-the-diverse-ancestral-populations-of-the-population-architecture-using-genomics-and-epidemiology-page-study-reveals-evidence-for-multiple-signals-at-established-loci
#17
Lindsay Fernández-Rhodes, Jian Gong, Jeffrey Haessler, Nora Franceschini, Mariaelisa Graff, Katherine K Nishimura, Yujie Wang, Heather M Highland, Sachiko Yoneyama, William S Bush, Robert Goodloe, Marylyn D Ritchie, Dana Crawford, Myron Gross, Myriam Fornage, Petra Buzkova, Ran Tao, Carmen Isasi, Larissa Avilés-Santa, Martha Daviglus, Rachel H Mackey, Denise Houston, C Charles Gu, Georg Ehret, Khanh-Dung H Nguyen, Cora E Lewis, Mark Leppert, Marguerite R Irvin, Unhee Lim, Christopher A Haiman, Loic Le Marchand, Fredrick Schumacher, Lynne Wilkens, Yingchang Lu, Erwin P Bottinger, Ruth J L Loos, Wayne H-H Sheu, Xiuqing Guo, Wen-Jane Lee, Yang Hai, Yi-Jen Hung, Devin Absher, I-Chien Wu, Kent D Taylor, I-Te Lee, Yeheng Liu, Tzung-Dau Wang, Thomas Quertermous, Jyh-Ming J Juang, Jerome I Rotter, Themistocles Assimes, Chao A Hsiung, Yii-Der Ida Chen, Ross Prentice, Lewis H Kuller, JoAnn E Manson, Charles Kooperberg, Paul Smokowski, Whitney R Robinson, Penny Gordon-Larsen, Rongling Li, Lucia Hindorff, Steven Buyske, Tara C Matise, Ulrike Peters, Kari E North
Most body mass index (BMI) genetic loci have been identified in studies of primarily European ancestries. The effect of these loci in other racial/ethnic groups is less clear. Thus, we aimed to characterize the generalizability of 170 established BMI variants, or their proxies, to diverse US populations and trans-ethnically fine-map 36 BMI loci using a sample of >102,000 adults of African, Hispanic/Latino, Asian, European and American Indian/Alaskan Native descent from the Population Architecture using Genomics and Epidemiology Study...
April 8, 2017: Human Genetics
https://www.readbyqxmd.com/read/28389622/il-4r%C3%AE-on-dendritic-cells-in-neonates-and-th2-immunopathology-in-respiratory-syncytial-virus-infection
#18
Bishwas Shrestha, Dahui You, Jordy Saravia, David T Siefker, Sridhar Jaligama, Greg I Lee, Asmaa A Sallam, Jeffrey N Harding, Stephania A Cormier
Respiratory syncytial virus (RSV) is one of the leading causes of bronchiolitis in children, and severe RSV infection early in life has been associated with asthma development. Using a neonatal mouse model, we have shown that down-regulation of IL-4 receptor α (IL-4Rα) with antisense oligonucleotides in the lung during neonatal infection protected from RSV immunopathophysiology. Significant down-regulation of IL-4Rα was observed on pulmonary CD11b(+) myeloid dendritic cells (mDCs) suggesting a role for IL-4Rα on mDCs in the immunopathogenesis of neonatal RSV infection...
April 7, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28388454/initial-steps-to-inform-selection-of-continuation-cognitive-therapy-or-fluoxetine-for-higher-risk-responders-to-cognitive-therapy-for-recurrent-major-depressive-disorder
#19
Jeffrey R Vittengl, Lee Anna Clark, Michael E Thase, Robin B Jarrett
Responders to acute-phase cognitive therapy (A-CT) for major depressive disorder (MDD) often relapse or recur, but continuation-phase cognitive therapy (C-CT) or fluoxetine reduces risks for some patients. We tested composite moderators of C-CT versus fluoxetine's preventive effects to inform continuation treatment selection. Responders to A-CT for MDD judged to be at higher risk for relapse due to unstable or partial remission (N=172) were randomized to 8 months of C-CT or fluoxetine with clinical management and assessed, free from protocol treatment, for 24 additional months...
March 22, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28388032/a-microporous-amic-acid-polymer-for-enhanced-ammonia-capture
#20
Ji-Woong Lee, Gokhan Barin, Gregory W Peterson, Jun Xu, Kristen A Colwell, Jeffrey R Long
Amic acids, consisting of carboxylic acids and amides, are often utilized as intermediates that can further undergo a dehydration-cyclization step to yield polymeric cyclic imides. Compared with imide-based materials, the presence of Brønsted acidic groups and multiple hydrogen-bond donors and acceptors in materials incorporating amic acids opens up the possibility for a variety of host-guest interactions. Here we report a facile and catalyst-free synthesis of a Brønsted acidic porous poly(amic acid) (PAA) and present its NH3 uptake properties using gas adsorption and breakthrough measurements...
April 7, 2017: ACS Applied Materials & Interfaces
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