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Cryopreserved allograft

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https://www.readbyqxmd.com/read/29678647/post-mortem-retrieval-of-arterial-allografts-preliminary-results
#1
Dorian Verscheure, Julien Gaudric, Jérémie Jayet, Philippe Tresson, Mohamed Jarraya, Pierre Julia, Marc Coggia, Laurent Chiche, Fabien Koskas
OBJECTIVES: Cryopreserved arterial allografts are vascular substitutes used for arterial reconstructions in a septic field. Their use remains however limited by the shortage of donors. One of the possibilities to address this lack of grafts is to multiply the sources of retrieval. The objective of this preliminary study was the evaluation of the early clinical results and the microbiological safety of arterial grafts retrieved after death. MATERIAL AND METHODS: In addition to the standard conditions of arterial sampling the criteria of inclusion for postmortem retrieval comprised the refrigeration of the body of the donor within four hours following the death, a 24-hour time limit from the death, and the availability of an adapted place for retrieval (surgical unit or death chamber respecting the required aseptic conditions)...
April 17, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29675506/large-osteochondral-allografts-of-the-knee-surgical-technique-and-indications
#2
REVIEW
Gabriele Pisanu, Umberto Cottino, Federica Rosso, Davide Blonna, Antonio Giulio Marmotti, Corrado Bertolo, Roberto Rossi, Davide E Bonasia
Large osteochondral allograft (OCA) transplant has become a valid alternative to restore articular surface in challenging articular lesions in young and active patients, either in primary or in revision procedures. Several studies support the effectiveness and safety of OCA, but costs and graft availability limit their use. The indications are the treatment of symptomatic full-thickness cartilage lesions greater than 3 cm 2 , deep lesions with subchondral damage, or revision procedures when a previous treatment has failed...
March 2018: Joints
https://www.readbyqxmd.com/read/29657478/cryopreserved-bone-allograft-for-the-treatment-of-shoulder-instability-with-glenoid-defect
#3
Mina M Abdelshahed, Steven D Shamah, Siddharth A Mahure, Brent Mollon, Young W Kwon
The purpose of this study was to examine outcomes after cryopreserved tri-cortical iliac crest allograft reconstruction for glenoid bone loss in patients with shoulder instability. 10 patients completed the required assessments at a mean follow up of 4.5 years. At final follow up, mean ASES was 92 ± 12, mean WOSI was 315 ± 319, with good range of motion. None of the final radiographs demonstrated graft resorption or failure of hardware. The data demonstrated that patients who were treated with glenoid bone grafting with cryopreserved tri-cortical iliac crest allograft can expect good range of motion and functional capacity...
March 2018: Journal of Orthopaedics
https://www.readbyqxmd.com/read/29644144/comparative-effectiveness-of-a-bioengineered-living-cellular-construct-and-cryopreserved-cadaveric-skin-allograft-for-the-treatment-of-venous-leg-ulcers-in-a-real-world-setting
#4
Terry Treadwell, Michael L Sabolinski, Michelle Skornicki, Nathan B Parsons
Objective: A variety of advanced biological therapies are available for the treatment of chronic wounds such as venous leg ulcers (VLUs), but real-world comparative effectiveness data that can help guide decisions around treatments are currently lacking. Approach: This analysis was designed to compare the effectiveness of a bioengineered living cellular construct (BLCC) to a cryopreserved cadaveric skin allograft (CCSA) for the treatment of VLUs. Treatment records were collected from a large wound care-specific electronic medical record database on 717 patients (799 VLUs) receiving treatment at 177 wound care centers...
March 1, 2018: Advances in Wound Care
https://www.readbyqxmd.com/read/29644033/a-case-of-dupuytren-s-disease-managed-with-viable-cryopreserved-placental-membrane-adjunct-to-open-palmar-fasciectomy
#5
Christopher M Dress, Elisabet K Tassis
Dupuytren's disease (DD) is a rare connective tissue disorder resulting in progressive fibrosis and thickening of the palmar fascia, and contracture of the fingers due to excessive collagen deposition. Staged surgical interventions are reserved for severe cases, yet worsening of fibrosis and contracture of fingers post-surgery, has been reported to have a recurrence rate as high as 85%. Here, the authors report on use of viable cryopreserved placental membrane (vCPM) allograft as an adjunct to open fasciectomy...
March 2018: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29554248/fresh-decellularized-versus-standard-cryopreserved-pulmonary-allografts-for-right-ventricular-outflow-tract-reconstruction-during-the-ross-procedure-a-propensity-matched-study
#6
Jonathan Richard Gregory Etnel, Paula Hansen Suss, Gabriela Miotto Schnorr, Myriam Veloso, Daniele Fornazari Colatusso, Eduardo Mendel Balbi Filho, Francisco Diniz Affonso da Costa
OBJECTIVES: Recent studies have shown favourable early results with decellularized allografts (DAs) for right ventricular outflow tract reconstruction during the Ross procedure. However, mid- and long-term outcome data are still scarce. The objective of this study was to compare the durability of fresh DAs with standard cryopreserved allografts (SCAs) in patients undergoing the Ross procedure. METHODS: Two hundred patients underwent the Ross procedure with DA and 202 with SCA...
March 14, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29522567/the-cryoprotectant-trehalose-could-inhibit-ers-induced-apoptosis-by-activating-autophagy-in-cryoprotected-rat-valves
#7
Hongyan Wu, Qing Chang
Valvular diseases are common health problems that are strongly related to high morbidity and mortality; aortic valve allograft transplantation may be a promising way to improve survival and relieve symptoms. However, ideal tissue viability has not been observed with common valve cryopreservation methods, which could lead to apoptosis and necrosis in cryopreserved tissue. It has been observed that trehalose plays a positive role by acting to maintain cell structures and protect cells from stress responses. In this study, we studied the effects of trehalose in protecting rat valve tissue from the cooling process...
2018: PloS One
https://www.readbyqxmd.com/read/29518518/right-subclavian-septic-pseudo-aneurysm-with-esophageal-fistula-due-to-a-swallowed-fishbone
#8
Tresson Philippe, Ballabio Fabrizia, Manceau Gilles, Adam Nicolas, Lawton James, Davaine Jean-Michel, Koskas Fabien
Pseudoaneurysm due to a swallowed fish bone rarely involves subclavian arteries. A 46-year-old male with non-aberrant right subclavian artery presented pseudoaneurysm and brachial plexus septic necrosis. Open surgery with sternotomy and right transverse supraclavicular cervicotomy was done in emergency to achieve revascularization by in situ cryopreserved arterial allograft. Infection severity led to septic allograft rupture that necessitated ligation without new arterial reconstruction. During follow-up patient remained alive 8 months after surgery...
March 5, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29515701/cryopreserved-human-allografts-for-the-reconstruction-of-aortic-and-peripheral-prosthetic-graft-infection
#9
Matteo Bossi, Matteo Tozzi, Marco Franchin, Stefania Ferraro, Nicola Rivolta, Massimo Ferrario, Chiara Guttadauro, Patrizio Castelli, Gabriele Piffaretti
Background : This study aimed to present cases with cryopreserved human allografts (CHAs) for vascular reconstruction in both aortic and peripheral infected prosthetic grafts. Materials and Methods : This is a single center, observational descriptive study with retrospective analysis. In all cases, the infected prosthetic graft material was completely removed. At discharge, patients were administered anticoagulants. Follow-up examinations included clinical visits, echo-color-Doppler ultrasounds, or computed tomography angiography within 30 days and at 3, 6, and 12 months after the treatment, and then twice per year...
December 25, 2017: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/29514217/downsized-cryopreserved-and-standard-sized-allografts-for-right-ventricular-outflow-tract-reconstruction-in-children-long-term-single-institutional-experience
#10
Jamie L R Romeo, Grigorios Papageorgiou, Pieter C van de Woestijne, Johanna J M Takkenberg, Lauren E H Westenberg, Ingrid van Beynum, Ad J J C Bogers, Mostafa M Mokhles
OBJECTIVES: The objective of this study was to determine long-term results with bicuspidalized allografts compared to non-bicuspidalized allografts in children under 2 years undergoing primary correction of the right ventricular outflow tract. METHODS: Thirty-five consecutive bicuspidalized allografts were compared to 45 consecutive non-bicuspidalized allografts implanted during the same period. Valve-related events were analysed with Kaplan-Meier and Cox-regression techniques...
March 3, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29502254/organization-model-for-allotransplantations-of-cryopreserved-vascular-grafts-in-czech-republic
#11
Miroslav Špaček, Pavel Měřička, Libor Janoušek, Petr Štádler, Miloš Adamec, Robert Vlachovský, Igor Guňka, Pavel Navrátil, Filip Thieme, Petr Mitáš, Rudolf Špunda, Jaroslav Špatenka, Robert Staffa, Petr Němec, Jaroslav Lindner
The transplantation of fresh or cryopreserved vascular allografts in patients with a prosthetic graft infection or critical limb ischemia is necessary for their limb salvage and, in many cases, represents a lifesaving procedure. While transplantation of fresh allografts has a long history in the Czech Republic, the standard use of cryopreserved vascular allografts was introduced into the clinical practice in 2011 as a result of the implementation of EU Directive 2004/23/EC into national legislation (Human Cell and Tissue Act No...
March 3, 2018: Cell and Tissue Banking
https://www.readbyqxmd.com/read/29483480/-aortic-root-replacement-with-cryopreserved-allograft-aortic-valve
#12
Haruo Yamauchi, Minoru Ono
Aortic root replacement with a cryopreserved allograft aortic valve is effective for active infectious endocarditis and prosthetic valve endocarditis, especially with a perivalvular abscess, since an allograft seems to be resistant to infection by maintaining viable cells under the process of programmed freezing. From December 1998 to March 2017, aortic root replacement with allograft aortic valves were performed in 38 patients in the University of Tokyo. The in-hospital mortality was 18%, the 5-year survival rate was 68%, and the 5-year freedom rate of reoperation was 75%...
January 2018: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/29399449/viable-osteochondral-allograft-for-the-treatment-of-a-full-thickness-cartilage-defect-of-the-patella
#13
Jarret M Woodmass, Heath P Melugin, Isabella T Wu, Daniel B F Saris, Michael J Stuart, Aaron J Krych
Isolated cartilage defects can lead to significant pain and disability, prompting the development of a number of options for restorative treatment. Each method has advantages and limitations, and no single technique has gained widespread use. We present a technique for implantation of a cryopreserved osteochondral allograft (Cartiform) for the treatment of full-thickness cartilage defects. Cartiform is a cryopreserved osteochondral allograft composed of chondrocytes, chondrogenic growth factors, and extracellular matrix proteins...
October 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/29322685/feasibility-safety-and-tolerance-of-mesenchymal-stem-cell-therapy-for-obstructive-chronic-lung-allograft-dysfunction
#14
Cesar Ariel Keller, Thomas Arthur Gonwa, David Orel Hodge, Derek Joseph Hei, John Michael Centanni, Abba Chedi Zubair
Feasibility, tolerance, and safety of intravenous infusions of allogeneic mesenchymal stem cell (MSC) therapy in lung transplant recipients with bronchiolitis obliterans syndrome (BOS) are not well established. MSCs were manufactured, cryopreserved, transported to our facility, thawed, and infused into nine recipients with moderate BOS (average drop in forced expiratory volume in 1 second was 56.8% ± 3.2% from post-transplant peak) who were refractory to standard therapy and not candidates for retransplant...
February 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29275037/open-surgical-implantation-of-a-viable-intact-cryopreserved-human-placental-membrane-for-the-treatment-of-recalcitrant-plantar-fasciitis-case-report-with-greater-than-2-year-follow-up-duration
#15
Xingbo P Sun, Amy G Wilson, Georgina M Michael
Plantar fasciitis is one of the most common conditions encountered by a podiatric physician. Although most individuals respond well to traditional conservative and surgical remedies, a portion of patients will exhaust all available treatment options and will experience ongoing pain that can ultimately affect their quality of life. There has been an increase in scientific and clinical research surrounding the medical use of human placental membranes (HPMs) and many of these point-of-care allografts are now commercially available...
December 20, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29274525/in-vitro-biomechanical-and-hydrodynamic-characterisation-of-decellularised-human-pulmonary-and-aortic-roots
#16
A Desai, T Vafaee, P Rooney, J N Kearney, H E Berry, E Ingham, J Fisher, L M Jennings
BACKGROUND AND PURPOSE OF THE STUDY: The use of decellularised biological heart valves in the replacement of damaged heart valves offers a promising solution to reduce the degradation issues associated with existing cryopreserved allografts. The purpose of this study was to assess the effect of low concentration sodium dodecyl sulphate decellularisation on the in vitro biomechanical and hydrodynamic properties of cryopreserved human aortic and pulmonary roots. METHOD: The biomechanical and hydrodynamic properties of cryopreserved decellularised human aortic and pulmonary roots were fully characterised and compared to cellular human aortic and pulmonary roots in an unpaired study...
March 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29248126/management-of-the-infected-aortic-endograft
#17
REVIEW
Kamphol Laohapensang, Supapong Arworn, Saranat Orrapin, Termpong Reanpang, Saritphat Orrapin
Although the incidence of abdominal and thoracic aortic endograft infection is infrequent, ranging between 0.2% and 5%, stent-graft infection carries significant morbidity and mortality and exemplifies a formidable therapeutic challenge. The treatment goal is to eradicate the infectious process by endograft explantation, regional tissue debridement, and arterial reconstruction by either an extra-anatomic or in situ grafting procedure using autologous vein, cryopreserved allograft, or antibiotic-soaked prosthetic grafts...
June 2017: Seminars in Vascular Surgery
https://www.readbyqxmd.com/read/29245303/viable-placental-allograft-as-a-biological-dressing-in-the-clinical-management-of-full-thickness-thermal-occupational-burns-two-case-reports
#18
Eric L Johnson, Elisabet K Tassis, Georgina M Michael, Susan G Whittinghill
RATIONALE: Occupational burn injuries can be detrimental and difficult to manage. The majority of complex cases are referred and managed at regional burn centers where access to specialized care is available. As an alternative to hospitalization with staged surgical procedures, placental products may be used for outpatient medical management of these common burn injuries, especially if access to a regional burn center is limited or restricted.Fresh amnion has been a treatment of choice in burns for more than 100 years...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29225157/the-effect-of-amniotic-membrane-grafting-on-healing-and-wound-strength-after-strabismus-surgery-in-a-rabbit-model
#19
Jeffrey B Kennedy, Marissa B Larochelle, Michelle G Pedler, J Mark Petrash, Robert W Enzenauer
BACKGROUND: Amniotic membrane grafts (AMGs) are used, with mixed results, as a platform for ocular healing and to reduce pathologic scarring. This study evaluated wound tensile strength and histopathologic changes after strabismus surgery with AMGs in 20 New Zealand white rabbits. METHODS: All subjects underwent 4 mm inferior rectus hang-back recessions to both eyes. The right eyes served as controls. Ten left eyes (group 1) received processed dehydrated amniotic membrane allografts (Ambiodry2, IOP Inc, Costa Mesa, CA) and ten left eyes (group 2) received cryopreserved human amniotic membrane allografts (AmnioGraft, Bio-Tissue, Miami, FL) between the sclera and muscle insertion and between the muscle and repositioned conjunctiva...
February 2018: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/29208929/the-choice-of-cryopreservation-method-affects-immune-compatibility-of-human-cardiovascular-matrices
#20
Maria Schneider, Christof Stamm, Kelvin G M Brockbank, Ulrich A Stock, Martina Seifert
Conventional frozen cryopreservation (CFC) is currently the gold standard for cardiovascular allograft preservation. However, inflammation and structural deterioration limit transplant durability. Ice-free cryopreservation (IFC) already demonstrated matrix structure preservation combined with attenuated immune responses. In this study, we aim to explore the mechanisms of this diminished immunogenicity in vitro. First, we characterized factors released by human aortic tissue after CFC and IFC. Secondly, we analyzed co-cultures with human peripheral blood mononuclear cells, purified monocytes, T cells and monocyte-derived macrophages to examine functional immune effects triggered by the tissue or released cues...
December 5, 2017: Scientific Reports
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