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Cryopreserved allograft

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https://www.readbyqxmd.com/read/28976835/use-of-cryopreserved-umbilical-cord-with-negative-pressure-wound-therapy-for-complex-diabetic-ulcers-with-osteomyelitis
#1
A Raphael, J Gonzales
OBJECTIVE: The objective of this study was to evaluate the combined use of cryopreserved human umbilical cord (cUC) allograft and negative pressure wound therapy (NPWT) in treating complex diabetic foot ulcers (DFUs) with bone exposure and osteomyelitis. These types of wound are known to carry a high morbidity and mortality. METHODS: A single-center, retrospective chart review was performed to assess the efficacy of the combined use of cUC with NPWT, by the same surgeon, to help promote the closure of complex DFUs presenting with biopsy-proven osteomyelitis...
October 1, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28944517/biomechanical-comparison-of-xenogeneic-bone-material-treated-with-different-methods
#2
Wei Feng, Dongsong Li, Junting Zang, Li Fu
Bone xenografting is considered one of the most effective ways to address the shortage of bone autografts and allografts. Various methods have been employed to minimize the immune rejection issues associated with bone xenografts. However, the side effects of such methods on bone biomechanical properties remain unclear. As such, the objective of this study was to compare the influence of different treatments on the biomechanical properties of porcine bones. Fresh pig ribs were cut into 1.5 × 0.5 × 0.4 cm specimens, which were randomly divided into four groups and subjected to different modification regimes: group A by degreasing and partial deproteinization, group B by cryopreservation, group C by cryopreservation and enzyme digestion, and group D was a control group using fresh bone...
September 24, 2017: Xenotransplantation
https://www.readbyqxmd.com/read/28942372/restoration-of-fresh-cat-ovarian-tissue-function-by-autografting-to-subcutaneous-tissue-a-pilot-study
#3
Ellen C R Leonel, Janice M V Vilela, Raísa E G Paiva, José L P R Jivago, Rodrigo S Amaral, Carolina M Lucci
Ovarian tissue transplantation could be a valuable technique for the preservation of endangered animals. The domestic cat affords an adequate experimental model for studies aimed at wild felids due to its phylogenetic similarity. Thus, this pilot study evaluated the efficacy of cat ovarian tissue autotransplantation to a peripheral site. Three adult queens were submitted to ovariohysterectomy. The ovaries were fragmented into eight pieces; two were fixed as a control and six were transplanted to subcutaneous tissue of the dorsal neck...
September 15, 2017: Theriogenology
https://www.readbyqxmd.com/read/28893393/the-influence-of-cryopreservation-and-quick-freezing-on-the-mechanical-properties-of-tendons
#4
Irina Oswald, Markus Rickert, Gert-Peter Brüggemann, Anja Niehoff, Carlos Alfonso Fonseca Ulloa, Alexander Jahnke
In order to maintain their native properties, cryopreserved tendons are usually used in biomechanical research and in transplantation of allogenic tendon grafts. The use of different study protocols leads to controversy in literature and thus complicates the evaluation of the current literature. The aim of this study consisted in examining the influence of different freezing and thawing temperatures on the mechanical properties of tendons. 60 porcine tendons were frozen at either -80°C or -20°C for 7days and thawed at room or body temperature for 240 or 30min, respectively...
August 26, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28890027/cryopreserved-cadaveric-arterial-allograft-for-arterial-reconstruction-in-patients-with-prosthetic-infection
#5
Anne Lejay, Charline Delay, Elie Girsowicz, Bettina Chenesseau, Emilie Bonnin, Mohamed-Zied Ghariani, Fabien Thaveau, Yannick Georg, Bernard Geny, Nabil Chakfe
OBJECTIVE: The aim of this study was to report outcomes of cryopreserved arterial allografts used as a vascular substitute in the setting of prosthetic material infection. METHODS: A retrospective analysis of prospectively collected data was conducted including all consecutive interventions performed with cryopreserved arterial allografts used for vascular reconstruction in the setting of prosthetic material infection between January 2005 and December 2014. Five year outcomes included allograft related re-interventions, survival, primary patency, and limb salvage rates...
September 7, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28844199/cryopreservation-versus-fresh-frozen-meniscal-allograft-a-biomechanical-comparative-analysis
#6
Shukur Ahmad, Vivek Ajit Singh, Shamsul Iskandar Hussein
Meniscal allograft transplantation may be a better alternative for the treatment of irreparable meniscal injury compared to other forms of treatment. However, it remains to be seen whether the use fresh frozen allograft is better than cryopreserved allograft in treating this type of injury. We hypothesized that cryopreserved meniscal allograft would work better in maintaining the original biomechanical properties compared to fresh frozen ones, due to the lower amount of damage it incurs during the storage process...
September 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28843983/commentary-on-cryopreserved-cadaveric-arterial-allograft-for-arterial-reconstruction-in-patients-with-prosthetic-graft-infection
#7
J-B Ricco, F Schneider
No abstract text is available yet for this article.
August 23, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28840004/effects-of-cryopreservation-on-tracheal-allograft-antigenicity-in-dogs
#8
Tao Lu, Yiwei Huang, Yu Liu, Yaxing Shen, Yulei Qiao, Yongxing Zhang
BACKGROUND: Prolonged cryopreservation (~8-10 months) has been shown to reduce the antigenicity of tracheal allografts due to subsequent denuding of epithelium. In the present study, tracheal epithelium was assessed after variable periods of cryopreservation. Immunosuppressant-free allotransplantation was then undertaken to evaluate the impact of cryopreservation on tracheal antigenicity in dogs. METHODS: Tracheal rings [7-8] were removed from mongrel adult dogs for cryopreservation (1-10 months, -85 °C) and grafting...
July 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28826728/cryopreserved-arterial-allografts-for-in-situ-reconstruction-of-abdominal-aortic-native-or-secondary-graft-infection
#9
Sabrina Ben Ahmed, Adrien Louvancourt, Guillaume Daniel, Pierre Combe, Ambroise Duprey, Jean-Noël Albertini, Jean-Pierre Favre, Eugenio Rosset
OBJECTIVE: The objective of this study was to evaluate the early and long-term outcome of cryopreserved arterial allografts (CAAs) used for in situ reconstruction of abdominal aortic native or secondary graft infection and to identify predictors of mortality. METHODS: We retrospectively included 71 patients (mean age, 65.2 years [range, 41-84 years]; men, 91.5%) treated for abdominal aortic native or secondary graft infection (65 prosthetic graft infections; 16 of them had secondary aortoenteric fistula, 2 venous graft infections, and 4 mycotic aneurysms) by in situ reconstruction with CAA in the university hospitals of Clermont-Ferrand and Saint-Etienne from 2000 to 2016...
August 18, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28756719/endograft-infection-after-endovascular-abdominal-aortic-aneurysm-repair-a-systematic-review-and-meta-analysis
#10
Christos Argyriou, George S Georgiadis, Miltos K Lazarides, Efstratios Georgakarakos, George A Antoniou
PURPOSE: To report a meta-analysis of the published evidence on the outcomes of aortic endograft infection after endovascular aneurysm repair (EVAR). METHODS: A search of electronic information sources (PubMed/MEDLINE, SCOPUS, CENTRAL) and bibliographic reference lists identified 12 studies reporting on 362 patients (mean age 72 years; 279 men). The methodological quality of the selected studies was assessed using the Newcastle-Ottawa scale. Endpoints were 30-day/in-hospital mortality and follow-up mortality...
July 1, 2017: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/28738433/implantation-of-a-novel-cryopreserved-viable-osteochondral-allograft-for-articular-cartilage-repair-in-the-knee
#11
C Thomas Vangsness, Geoffrey Higgs, James K Hoffman, Jack Farr, Philip A Davidson, Farrell Milstein, Sandra Geraghty
No abstract text is available yet for this article.
July 24, 2017: Journal of Knee Surgery
https://www.readbyqxmd.com/read/28711452/hematopoietic-stem-cell-transplantation-in-algeria
#12
REVIEW
Mohamed Amine Bekadja, Mohamed Brahimi, Soufi Osmani, Nabil Yafour, Amina Krim, Faiza Serradj, Souad Talhi, Kamila Amani, Rachid Amar Bouhass
INTRODUCTION: Algeria is a country of 40,.4 million inhabitants and half of which is under 30years. In Algeria, Health-care insurance covered, 90% of the population. Health care is free and it is supported by the Ministry of Health. 16 university hospitals exist in Algeria and only two (Algiers and Oran) practicing bone marrow transplant. Adult hematologic malignancies account for 10% (about 4000 new cases/year) of the malignancy affecting in most cases young patients under 65years of age...
July 11, 2017: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/28647193/cryopreserved-venous-allograft-is-an-acceptable-conduit-in-patients-with-current-or-prior-angioaccess-graft-infection
#13
MULTICENTER STUDY
Michael P Harlander-Locke, Peter F Lawrence, Aamna Ali, Esther Bae, James Kohn, Christopher Abularrage, Michael Ricci, Gary W Lemmon, Sotero Peralta, Jeffrey Hsu
OBJECTIVE: The durability of cryopreserved allograft has been previously demonstrated in the setting of infection. The objective of this study was to examine the safety, efficacy, patency, and cost per day of graft patency associated with using cryopreserved allograft (vein and artery) for hemodialysis access in patients with no autogenous tissue for native fistula creation and with arteriovenous graft infection or in patients at high risk for infection. METHODS: Patients implanted with cryopreserved allograft for hemodialysis access between January 2004 and January 2014 were reviewed using a standardized, multi-institutional database that evaluated demographic, comorbidity, procedural, and outcomes data...
October 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28640792/alloimmunization-after-cryopreserved-arterial-allografts-in-a-patient-on-a-kidney-transplantation-waiting-list
#14
Cyril Garrouste, Eugenio Rosset, Fabienne Quainon, Julien Aniort, Anne Elisabeth Heng
No abstract text is available yet for this article.
July 2017: Transplantation
https://www.readbyqxmd.com/read/28602591/skin-grafts-from-genetically-modified-%C3%AE-1-3-galactosyltransferase-knockout-miniature-swine-a-functional-equivalent-to-allografts
#15
D A Leonard, C Mallard, A Albritton, R Torabi, M Mastroianni, D H Sachs, J M Kurtz, C L Cetrulo
Burn is associated with a considerable burden of morbidity worldwide. Early excision of burned tissue and skin grafting of the resultant wound has been established as a mainstay of modern burn therapy. However, in large burns, donor sites for autologous skin may be limited. Numerous alternatives, from cadaver skin to synthetic substitutes have been described, each with varying benefits and limitations. We previously proposed the use of genetically modified (alpha-1,3-galactosyl transferase knockout, GalT-KO) porcine skin as a viable skin alternative...
June 8, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28578619/a-meta-analysis-of-outcomes-after-in-situ-reconstructions-for-aortic-graft-infection
#16
Michel Batt, Patrick Feugier, Fabrice Camou, Amandine Coffy, Eric Senneville, Jocelyne Caillon, Brigitte Calvet, Christian Chidiac, Frederic Laurent, Matthieu Revest, Jean Pierre Daures
OBJECTIVE: To confirm the advantage of in situ reconstruction (ISR) over extra-anatomic reconstruction (EAR) for aortic graft infection and determine the most appropriate conduit including autogenous veins, cryopreserved allografts, and synthetic prosthesis (standard, rifampicin of silver polyesters). METHODS: A meta-analysis was conducted with rate of mortality, graft occlusion, amputation, and reinfection. A meta-regression was performed with 4 factors: patients' age, presence of prosthetic-duodenal fistula (PDF), virulent organisms, or nonvirulent organisms...
January 1, 2017: Angiology
https://www.readbyqxmd.com/read/28577843/glutaraldehyde-treatment-of-allografts-and-aortic-outcomes-post-norwood-challenging-surgical-decision
#17
Billie-Jean Martin, Michael Kaestner, Mingkai Peng, David B Ross, Simon Urschel, Lori J West, Ivan M Rebeyka
BACKGROUND: Glutaraldehyde (GA) treatment of allografts used for arch reconstruction prevents the immunologic sensitization that occurs with untreated allografts, but its use may cause tissue changes that predispose to recurrent obstruction. The objective was to determine whether GA treatment of allografts used in Norwood procedures increases the risk of recurrent aortic obstruction. METHODS: All infants who underwent a Norwood procedure between 2000 and 2015 were included...
October 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28561655/fertility-cardiac-and-orthopedic-challenges-in-survivors-of-adult-and-childhood-sarcoma
#18
Emma R Lipshultz, Ginger E Holt, Ranjith Ramasamy, Raphael Yechieli, Steven E Lipshultz
The combination of cisplatin, doxorubicin, and methotrexate was established as the standard backbone of contemporary osteosarcoma therapy in 1986. Since then, however, further improving the survival of patients with osteosarcoma has been challenging-30% to 40% of patients with osteosarcoma still die of this disease. In addition, these patients often experience loss of fertility at a young age, short- and long-term treatment-related cardiotoxicity, and adverse orthopedic effects from surgical resection of the tumor or endoprosthetic reconstructions...
2017: American Society of Clinical Oncology Educational Book
https://www.readbyqxmd.com/read/28502546/cryopreserved-saphenous-vein-as-a-last-ditch-conduit-for-limb-salvage
#19
Leigh Ann O'Banion, Bian Wu, Charles M Eichler, Linda M Reilly, Michael S Conte, Jade S Hiramoto
OBJECTIVE: In patients lacking autogenous vein suitable for infrainguinal bypass, cryopreserved saphenous vein (CSV) allograft (CryoLife, Inc, Kennesaw, Ga) may be an acceptable alternative. The purpose of this study was to examine outcomes of CSV conduit for infrainguinal revascularization. METHODS: Between February 2008 and August 2015, 70 patients underwent infrainguinal bypass grafts in 73 limbs using CSV. All patients lacked suitable arm or leg vein. Demographic data and patient outcomes were retrospectively collected using electronic medical records...
September 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28499737/endovascular-repair-as-a-bridge-to-open-repair-of-a-ruptured-descending-thoracic-aspergilus-aortitis
#20
Philippe Tresson, Arnaud Roussel, Pierre Mordant, Pierre Cerceau, Yves Castier, Quentin Pellenc
Invasive aspergillosis rarely involves the thoracic aorta, and is associated with a poor prognosis. A heart-transplanted 56-year old patient presented with invasive aspergillosis, primary aspergillus aortitis, and ruptured thoracic aorta pseudoaneurysm. Open surgery was not possible due to severe sepsis. A sequential surgical strategy was therefore decided, including emergency thoracic endovascular aneurysm repair, followed by antifungal treatment, and definitive open repair with explantation of the endograft and placement of a cryopreserved arterial allograft under extra-corporeal membrane oxygenator support...
May 9, 2017: Annals of Thoracic Surgery
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