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Cryopreserved allograft

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https://www.readbyqxmd.com/read/28186707/mesenchymal-stromal-cell-therapy-for-chronic-lung-allograft-dysfunction-results-of-a-first-in-man-study
#1
Daniel C Chambers, Debra Enever, Sharon Lawrence, Marian J Sturm, Richard Herrmann, Stephanie Yerkovich, Michael Musk, Peter M A Hopkins
Chronic lung transplant rejection (termed chronic lung allograft dysfunction [CLAD]) is the main impediment to long-term survival after lung transplantation. Bone marrow-derived mesenchymal stromal cells (MSCs) represent an attractive cell therapy in inflammatory diseases, including organ rejection, given their relative immune privilege and immunosuppressive and tolerogenic properties. Preclinical studies in models of obliterative bronchiolitis and human trials in graft versus host disease and renal transplantation suggest potential efficacy in CLAD...
February 1, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28161484/twenty-year-experience-with-aorto-enteric-fistula-repair-gastrointestinal-complications-predict-mortality
#2
Atish Chopra, Lucyna Cieciura, J Gregory Modrall, R James Valentine, Jayer Chung
BACKGROUND: Aorto-enteric fistulae (AEF) represent a lethal subset of aortic graft infections. The optimal management of AEF remains unclear. We aimed to identify predictors of morbidity and mortality. STUDY DESIGN: We performed a single-center retrospective review of consecutive AEF repairs. Demographics, co-morbidities, and peri-operative variables were obtained. Descriptive statistics, Chi-squared, Kruskall-Wallis, and Cox proportional-hazards modeling were utilized where appropriate...
February 1, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28151005/allograft-heart-valves-current-aspects-and-future-applications
#3
Milan Lisy, Guenay Kalender, Katja Schenke-Layland, Kelvin G M Brockbank, Anna Biermann, Ulrich Alfred Stock
Human heart valve allografts continue to represent almost perfect substitutes for heart valves. They have optimal hemodynamic characteristics and are highly resistant to infections. The first clinical use of allograft heart valves was as homovitals being transplanted after antibiotic incubation without any preservation. Since 1968, relatively standardized frozen cryopreservation (SFC) has been employed, including storage in vapor-phase liquid nitrogen. Disadvantages, particularly in pediatric patients, are limited availability due to organ scarcity, inability to grow, degeneration, immune response, and long-term failure...
February 2, 2017: Biopreservation and Biobanking
https://www.readbyqxmd.com/read/28149251/a-major-burn-injury-in-a-liver-transplant-patient
#4
I Delikonstantinou, B Philp, D Kamel, D Barnes, P Dziewulski
Immunosuppressive therapy may aggravate the clinical course of a burned patient, primarily affecting wound healing and thus complicating permanent wound coverage. We hereby present the successful management of a 48-year-old female liver transplant recipient with a major burn injury, aiming to elucidate the effects of the patient's immunosuppression on surgical treatment. After admission to the Burns ITU, the patient underwent serial debridement of the burn and coverage with cryopreserved allografts. Despite immunosuppression, no prolonged survival of the allo-epidermis was documented...
September 30, 2016: Annals of Burns and Fire Disasters
https://www.readbyqxmd.com/read/28139472/microsurgical-tunica-albuginea-transplantation-in-an-animal-model
#5
Salvatore Sansalone, Carla Loreto, Rosario Leonardi, Giuseppe Vespasiani, Giuseppe Musumeci, Claudia Lombardo, Sergio Castorina, Venera Cardile, Rosario Caltabiano
Several andrological diseases require surgical repair or reconstruction of tunica albuginea, which envelops the corpora cavernosa penis. Despite intense research efforts involving a variety of biological materials, such as skin, muscle aponeurosis, human dura mater, tunica vaginalis, and pericardium, engineered tunica albuginea suitable for graft use is yet to be obtained. The study investigates microsurgical tunica albuginea allotransplantation in an animal model with the purpose of creation of an organ-specific tissue bank to store penile tissue, from cadaveric donors and male-to-female trans-sexual surgery, for allogeneic transplantation...
January 24, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28109571/in%C3%A2-vivo-tissue-engineering-of-human%C3%A2-airways
#6
Emmanuel Martinod, Joseph Paquet, Hervé Dutau, Dana M Radu, Morad Bensidhoum, Sébastien Abad, Yurdagül Uzunhan, Eric Vicaut, Hervé Petite
BACKGROUND: Airway transplantation remains a major challenge in thoracic surgery. Based on our previous laboratory work, we developed the techniques required to bioengineer a tracheal substitute in vivo using cryopreserved aortic allografts as biological matrices (Replacement of the Airways and/or the Pulmonary Vessels Using a Cryopreserved Arterial Allograft [TRACHEOBRONCART] Study, NCT01331863). We present here 2 patients who had a definitive tracheostomy for complex laryngotracheal stenoses refractory to conventional therapy...
January 18, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28058524/determination-of-residual-dimethylsulfoxide-in-cryopreserved-cardiovascular-allografts
#7
R Díaz Rodríguez, B Van Hoeck, S De Gelas, F Blancke, R Ngakam, K Bogaerts, R Jashari
Dimethylsulfoxide (DMSO) is a solvent which protects the structure of allografts during the cryopreservation and thawing process. However, several toxic effects of DMSO in patients after transplantation of cryopreserved allografts have been described. The aim of this study is to determine the residual DMSO in the cardiovascular allografts after thawing and preparation of cryopreserved allografts for clinical application following guidelines of the European Pharmacopoeia for DMSO detection. Four types of EHB allografts (aortic valve-AV, pulmonary valve-PV, descending thoracic aorta-DA, and femoral artery-FA) are cryopreserved using as cryoprotecting solution a 10% of DMSO in medium 199...
January 5, 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/28034338/bioengineering-strategies-to-treat-female-infertility
#8
Che-Ying Kuo, Hannah Baker, Melissa H Fries, James J Yoo, Peter C W Kim, John P Fisher
Bioengineering strategies have demonstrated enormous potential to treat female infertility as a result of chemotherapy, uterine injuries, fallopian tube occlusion, massive intrauterine adhesions, congenital uterine malformations, and hysterectomy. These strategies can be classified into two broad categories as follows: (i) Transplantation of fresh or cryopreserved organs into the host and (ii) tissue engineering approaches that utilize a combination of cells, growth factors, and biomaterials that leverages the body's inherent ability to regenerate/repair reproductive organs...
February 3, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28017933/20-years-experience-with-the-ross-operation-in-middle-aged-patients-the-autologous-principle-is-still-alive
#9
Francisco Diniz Affonso da Costa, Daniele Fornazari Colatusso, Eduardo Mendel Balbi Filho, Rafael Marchetti, Andreia Dumsch de Aragon Ferreira, Marise Brenner Affonso da Costa, Joao Gabriel Roderjan, Claudinei Colatusso
OBJECTIVES: Review our long-term results with the Ross operation in middle-aged patients. METHODS: Between 1995 and 2016, 129 consecutive patients (106 males); mean age (47.2 ± 5.2 years) underwent a Ross operation. Right ventricular outflow tract (RVOT) reconstruction was performed with cryopreserved (n = 45) or decellularized allografts (n = 84). Mean follow-up was 8.4 ± 5.3 years (0.1 -: 20.5 years). We analyzed early and late mortality, as well as valve related events and the need for reoperations...
December 25, 2016: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/27943656/decellularisation-of-human-donor-aortic-and-pulmonary-valved-conduits-using-low-concentration-sds
#10
Tayyebeh Vafaee, Daniel Thomas, Amisha Desai, Louise M Jennings, Helen Berry, Paul Rooney, John Kearney, John Fisher, Eileen Ingham
The clinical use of decellularised cardiac valve allografts is increasing. Long term data will be required to determine whether they outperform conventional cryopreserved allografts. Valves decellularised using different processes may show varied long-term outcomes. It is therefore important to understand the effects of specific decellularisation technologies on the characteristics of donor heart valves. Human cryopreserved aortic and pulmonary valved conduits were decellularised using hypotonic buffer, 0.1% (w/v) SDS and nuclease digestion...
December 12, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27825689/safety-and-effectiveness-of-cadaveric-allograft-sternochondral-replacement-after-sternectomy-a-new-tool-for-the-reconstruction-of-anterior-chest-wall
#11
Giuseppe Marulli, Andrea Dell'amore, Francesca Calabrese, Marco Schiavon, Niccolò Daddi, Giampiero Dolci, Franco Stella, Federico Rea
BACKGROUND: Surgical excision with wide margins, prevention of respiratory impairment, and protection of surrounding organs are primary goals in resection and reconstruction of the chest wall. We describe our experience of the use of cadaveric cryopreserved sternal allograft. METHODS: Eighteen patients underwent surgery. Indications for sternectomy were sternal metastases (n = 9), primary chondrosarcoma (n = 4), sternal dehiscence (n = 2), soft tissue sarcoma (n = 1), malignant solitary fibrous tumor (n = 1), and direct involvement of thymic carcinoma (n = 1)...
November 5, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27788940/performance-of-synergraft-decellularized-pulmonary-allografts-compared-with-standard-cryopreserved-allografts-results-from-multiinstitutional-data
#12
Steve Bibevski, Mark Ruzmetov, Randall S Fortuna, Mark W Turrentine, John W Brown, Richard G Ohye
BACKGROUND: Structural deterioration of allografts over time is believed to be at least partly related to an immune response mounted against human leukocyte antigen specific to the transplanted tissue. SynerGraft (SG) processing (CryoLife, Kennesaw, GA) is a technology that decellularizes an allograft leaving only connective tissue, therefore, reducing immunogenicity and potentially increasing durability of the implant. METHODS: We performed a retrospective review of 163 SG patients and 124 standard allograft controls from 3 medical centers...
October 24, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27729094/identification-of-donor-origin-and-condition-of-transplanted-islets-in-situ-in-the-liver-of-a-type-1-diabetic-recipient
#13
Cornelis R van der Torren, Jessica S Suwandi, DaHae Lee, Ernst-Jan T van 't Wout, Gaby Duinkerken, Godelieve Swings, Arend Mulder, Frans H J Claas, Zhidong Ling, Pieter Gillard, Bart Keymeulen, Peter In 't Veld, Bart O Roep
Transplantation of islet allografts into type 1 diabetic recipients usually requires multiple pancreas donors to achieve insulin independence. This adds to the challenges of immunological monitoring of islet transplantation currently relying on surrogate immune markers in peripheral blood. We investigated donor origin and infiltration of islets transplanted in the liver of a T1D patient who died of hemorrhagic stroke four months after successful transplantation with two intraportal islet grafts combining six donors...
October 10, 2016: Cell Transplantation
https://www.readbyqxmd.com/read/27720319/a-multicenter-experience-with-infected-abdominal-aortic%C3%A2-endograft-explantation
#14
Xavier Chaufour, Julien Gaudric, Yann Goueffic, Réda Hassen Khodja, Patrick Feugier, Sergei Malikov, Guillaume Beraud, Jean-Baptiste Ricco
OBJECTIVE: Endovascular aneurysm repair (EVAR) is widely used with excellent results, but its infectious complications can be devastating. In this paper, we report a multicenter experience with infected EVAR, symptoms, and options for explantation and their outcome. METHODS: We have reviewed all consecutive endograft explants for infection at 11 French university centers following EVAR, defined as index EVAR, from 1998 to 2015. Diagnosis of infected aortic endograft was made on the basis of clinical findings, cultures, imaging studies, and intraoperative findings...
February 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/27681806/treatment-of-large-complex-non-healing-wounds-with-cryopreserved-amniotic-suspension-allograft-a-case-series
#15
B Marcus
OBJECTIVE: Cryopreserved amniotic suspension allograft (CASA) is a regenerative tissue suspension containing amniotic membrane and amniotic fluid components used for soft-tissue repair, replacement, and reconstruction. The aim of this case series is to examine its effects in different wound types. METHOD: In a retrospective series CASA was applied to chronic non-healing wounds. All patients were treated at a single center between June 2013 and December 2014. The criterion for application of CASA was lack of progress toward wound healing despite standard treatments and adjuvant therapies...
October 2016: Journal of Wound Care
https://www.readbyqxmd.com/read/27625041/notch-expanded-murine-hematopoietic-stem-and-progenitor-cells-mitigate-death-from-lethal-radiation-and-convey-immune-tolerance-in-mismatched-recipients
#16
Filippo Milano, Fabiola Merriam, Ian Nicoud, Jianqiang Li, Ted A Gooley, Shelly Heimfeld, Suzan Imren, Colleen Delaney
: : The hematopoietic syndrome of acute radiation syndrome (h-ARS) is characterized by severe bone marrow aplasia, resulting in a significant risk for bleeding, infections, and death. To date, clinical management of h-ARS is limited to supportive care dictated by the level of radiation exposure, with a high incidence of mortality in those exposed to high radiation doses. The ideal therapeutic agent would be an immediately available, easily distributable single-agent therapy capable of rapid in vivo hematopoietic reconstitution until recovery of autologous hematopoiesis occurs...
September 13, 2016: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/27614553/late-fate-of-cryopreserved-arterial-allografts
#17
E Minga Lowampa, Ch Holemans, L Stiennon, H Van Damme, J O Defraigne
OBJECTIVE: Initial enthusiasm for use of cryopreserved arterial allografts was subsequently tempered by suboptimal long-term outcome. Thrombosis, anastomotic pseudo-aneurysm, allograft disruption, aneurysmal degeneration, recurrent intestinal fistulization, and persistent infection are commonly reported in series with long-term follow-up. The authors reviewed their experience over the past 15 years with the use of cryopreserved arterial allografts as a vascular substitute for vascular prosthetic infection or for primary arterial infection, to investigate allograft-related complications...
November 2016: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/27600522/biomechanical-and-histological-comparison-between-the-cryopreserved-and-the-lyophilized-gracilis-tendon-allograft-for-mpfl-reconstruction-a-cadaveric-experimental-study
#18
Roberto Negrín, Jaime Duboy, Fernando Olavarría, Mauricio Wainer, Horacio Jimenez, Facundo Las Heras, Nicolas Reyes, Hugo Godoy
BACKGROUND: Medial patellofemoral ligament (MPFL) is the main restrictor of lateral shifting of the patella, contributing by 60 % in the first 20° flexion of the knee. MPFL reconstruction has been performed in order to restore the stability of the patella with good results.Lyophilized Gracilis tendon allograft (LGA) compared to Cryopreserved Gracilis tendon allograft (CGA) has a lower cost, does not require to maintain cooling chain or preparation. The purpose of this study is to compare the histological and biomechanical characteristics of an experimental model of reconstruction of the MPFL in porcine patellas with LGA versus CGA...
December 2016: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/27592735/recent-results-of-in-situ-abdominal-aortic-reconstruction-with-cryopreserved-arterial-allograft
#19
S-H Heo, Y-W Kim, S-Y Woo, Y-J Park, D-K Kim, D-R Chung
OBJECTIVE: To evaluate treatment outcomes of in situ abdominal aortic reconstruction with cryopreserved arterial allograft (CAA) for patients with abdominal aortic infection. MATERIALS AND METHODS: A retrospective review of prospectively collected data was conducted of patients who underwent in situ aortic reconstruction using CAA for primary, secondary, or prosthetic infection of the abdominal aorta between May 2006 and July 2015, at a single institution. Clinical presentation, indications for treatment, procedural details, early post-operative mortality and morbidity, late death, and graft related complications during the follow up period were investigated...
September 1, 2016: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/27538107/characterization-of-a-cryopreserved-split-thickness-human-skin-allograft-theraskin
#20
Adam Landsman, Eran Rosines, Amanda Houck, Angela Murchison, Alyce Jones, Xiaofei Qin, Silvia Chen, Arnold R Landsman
OBJECTIVE: The purpose of this study was to examine the characteristics of a cryopreserved split-thickness skin allograft produced from donated human skin and compare it with fresh, unprocessed human split-thickness skin. BACKGROUND: Cutaneous wound healing is a complex and organized process, where the body re-establishes the integrity of the injured tissue. However, chronic wounds, such as diabetic or venous stasis ulcers, are difficult to manage and often require advanced biologics to facilitate healing...
September 2016: Advances in Skin & Wound Care
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