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https://www.readbyqxmd.com/read/28935932/cannabidiol-attenuates-alcohol-induced-liver-steatosis-metabolic-dysregulation-inflammation-and-neutrophil-mediated-injury
#1
Yuping Wang, Partha Mukhopadhyay, Zongxian Cao, Hua Wang, Dechun Feng, György Haskó, Raphael Mechoulam, Bin Gao, Pal Pacher
Cannabidiol (CBD) is a non-psychoactive component of marijuana, which has anti-inflammatory effects. It has also been approved by FDA for various orphan diseases for exploratory trials. Herein, we investigated the effects of CBD on liver injury induced by chronic plus binge alcohol feeding in mice. CBD or vehicle was administered daily throughout the alcohol feeding study. At the conclusion of the feeding protocol, serums samples, livers or isolated neutrophils were utilized for molecular biology, biochemistry and pathology analysis...
September 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28934821/feasibility-of-a-complete-pancreatobiliary-linear-endoscopic-ultrasound-examination-from-the-stomach
#2
Vinay Dhir, Douglas G Adler, Nonthalee Pausawasdi, Amit Maydeo, Khek Yu Ho
Background and study aims Linear endoscopic ultrasound (EUS) evaluation of the pancreaticobiliary system usually requires scanning from both the stomach and the duodenum. The feasibility of assessing the complete pancreaticobiliary system from the stomach alone has not been studied. We aimed to conceptualize a system-based approach (the railroad approach) for linear pancreaticobiliary EUS (PB-EUS) and evaluate whether the pancreaticobiliary anatomy could be assessed from the stomach alone. Patients and methods Three maneuvers were conceptualized and evaluated (the alpha maneuver in the stomach, and sigma and xi maneuvers in the duodenum)...
September 21, 2017: Endoscopy
https://www.readbyqxmd.com/read/28930036/role-for-laparoscopy-in-the-management-of-bile-duct-injuries
#3
Vaibhav Gupta, Shiva Jayaraman
Common bile duct (CBD) injury is the most serious complication of laparoscopic cholecystectomy. Recently, laparoscopic techniques have been used in the management of postoperative bile leak and CBD injury; this literature has not been reviewed. We reviewed the literature on CBD injury, the approach to its diagnosis and management, and reports of laparoscopic management techniques. We combined this review with our experience in laparoscopic methods to highlight diagnostic and therapeutic options. Laparoscopic techniques can be used to prevent, diagnose and treat CBD injuries...
September 2017: Canadian Journal of Surgery. Journal Canadien de Chirurgie
https://www.readbyqxmd.com/read/28922189/acr-acnm-practice-parameter-for-the-performance-of-dopamine-transporter-dat-single-photon-emission-computed-tomography-spect-imaging-for-movement-disorders
#4
Rathan M Subramaniam, Kirk A Frey, Christopher H Hunt, Gustavo A Mercier, Lilja B Solnes, Patrick M Colletti, Yang Lu, Bital Savir-Baruch, Hadyn T Williams
This American College of Radiology and American College of Nuclear Medicine joint clinical practice parameter is for performance of dopamine transporter single photon emission computed tomography (SPECT) imaging, for patients with movement disorders. Parkinsonian syndrome (PS) consists of a group of neurodegenerative diseases including Parkinson disease (PD), progressive supranuclear palsy (PSP), multiple system atrophy (MSA), corticobasal degeneration (CBD), and dementia with Lewy bodies (DLB). Accurate diagnosis of PS is critical for clinical management...
September 15, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28916859/near-infrared-cholecystocholangiography-with-direct-intragallbladder-indocyanine-green-injection-preliminary-clinical-results
#5
Yu-Yin Liu, Chien-Hung Liao, Michele Diana, Shang-Yu Wang, Seong-Ho Kong, Chun-Nan Yeh, Bernard Dallemagne, Jacques Marescaux, Ta-Sen Yeh
BACKGROUND: Near-infrared (NIR) fluorescence cholangiography by systemic administration of indocyanine green (ICG) enhances the visualization of the biliary tree anatomy. However, the simultaneous enhancement of liver parenchyma can disturb the visualization of critical details. We herein proposed a new technique of NIR cholecystocholangiography by intragallbladder ICG injection to increase the safety during laparoscopic cholecystectomy. METHODS: A total of 46 patients scheduled for laparoscopic cholecystectomy for symptomatic lithiasis (n = 21) or cholecystitis (n = 25) were enrolled...
September 15, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28912150/-18-f-fdg-pet-in-parkinsonism-differential-diagnosis-and-cognitive-impairment-in-parkinson-s-disease
#6
Philipp T Meyer, Lars Frings, Gerta Rücker, Sabine Hellwig
Accurate differential diagnosis of parkinsonism is of a paramount therapeutic and prognostic importance. In addition, with the development of invasive therapies and novel disease-specific therapies, strategies for patient enrichment in trial populations are of growing importance. Imaging disease-specific patterns of regional glucose metabolism with positron emission tomography and [(18)F]fluoro-2-deoxy-2-D-glucose ((18)F-FDG) allows for a highly accurate distinction between Parkinson's disease (PD) and atypical parkinsonian syndromes (APS) including multiple system atrophy (MSA), progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD)...
September 14, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28906372/efficacy-and-safety-of-laparoscopic-bile-duct-exploration-versus-endoscopic-sphincterotomy-for-concomitant-gallstones-and-common-bile-duct-stones-a-meta-analysis-of-randomized-controlled-trials
#7
Ying-Chao Gao, Jinjun Chen, Qiyu Qin, Hu Chen, Wei Wang, Jian Zhao, Fulong Miao, Xin Shi
BACKGROUND: The purpose of this study was to compare the efficacy and safety of laparoscopic cholecystectomy (LC) plus laparoscopic common bile duct (CBD) stones exploration (LCBDE) with LC plus endoscopic sphincterotomy (EST) in the treatment of patients with gallstones and CBD stones. METHODS: The authors searched PubMed, Web of Science, and Embase to identify relevant studies. Risk ratios (RRs) were pooled to compare stone clear, retained stone, conversion to other procedures, and complications...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28906054/neuropathological-comorbidity-associated-with-argyrophilic-grain-disease
#8
REVIEW
Osamu Yokota, Tomoko Miki, Chikako Ikeda, Shigeto Nagao, Shintaro Takenoshita, Hideki Ishizu, Takashi Haraguchi, Shigetoshi Kuroda, Seishi Terada, Norihito Yamada
Argyrophilic grain disease (AGD) is a common four-repeat tauopathy in elderly people. While dementia is a major clinical picture of AGD, recent studies support the possibility that AGD may be a pathological base in some patients with mild cognitive impairment, late-onset psychosis, bipolar disorder and depression. AGD often coexists with various other degenerative changes. The frequency of AGD in progressive supranuclear palsy (PSP) cases was reported to range from 18.8% to 80%. The frequency of AGD in corticobasal degeneration (CBD) cases tends to be higher than that in PSP cases, ranging from 41...
September 14, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/28902207/preparation-and-characterization-of-crfewtio2-photoanodes-and-their-photoelectrochemical-activities-for-water-splitting
#9
Mohamad Mohsen Momeni, Yousef Ghayeb, Mojgan Shafiei
The chemical bath deposition (CBD) method was successfully applied to prepare WTiO2 nanotube arrays co-deposited with chromium, iron and chromium-iron nanoparticles. Various methods have been used in the characterization of synthetic co-deposited nanostructures. WTiO2 nanotubes can keep the nanotubular structures at low iron concentration in the CBD solution, as indicated by our FESEM results. Iron and chromium can be applied to improve the absorption capability of the WTiO2 nanotubes for the visible-light, according to the UV-Vis results...
September 13, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28898308/-the-treatment-of-cannabis-dependence-clinical-work-psychotherapy-and-evidence
#10
José Capece, Federico Pavlovsky
Identifying compulsive consumption of marijuana in association with another mental disorder (attentional defcit disorder, bipolar disorder, depression or psychosis) presents the challenge of clarifying validated therapeutic strategies, especially within the teen population, in which it shows the highest prevalence. The ever-increasing prevalence and the need for regional treatments, demand that we approach this health matter as a public health issue. The ideological con?icts related to the necessary decriminalization of consumption and the current debate on the medical use of marijuana often confuse the urgent need to establish effective therapeutic strategies for the population affected by this mental disorder...
November 2016: Vertex: Revista Argentina de Psiquiatriá
https://www.readbyqxmd.com/read/28892911/benign-beale-gland-hyperplasia-mimicking-malignant-biliary-obstruction
#11
Durairaj Segamalai, Anand Lakshmanan, Abdul Rehman Abdul Jameel, Sofiya Chandrabapulu, Kannan Devy Gounder
Extrahepatic bile duct obstruction can be caused by various pathologies, most of them being malignant. Painless, progressive jaundice is the usual mode of presentation. We report a case of distal Common Bile Duct (CBD) obstruction due to a Benign Intramural Beale gland hyperplasia mimicking a periampullary carcinoma. Peribiliary glands (Beale Glands) are a group of seromucinous glands, normally seen within the fibromuscular wall and periductal connective tissue in the extrahepatic and large intrahepatic ducts and also in the neck of the Gall bladder...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28890215/piperine-pro-nanolipospheres-as-a-novel-oral-delivery-system-of-cannabinoids-pharmacokinetic-evaluation-in-healthy-volunteers-in-comparison-to-buccal-spray-administration
#12
Irina Cherniakov, Dvora Izgelov, Dinorah Barasch, Elyad Davidson, Abraham J Domb, Amnon Hoffman
Nowadays, therapeutic indications for cannabinoids, specifically Δ(9)-tetrahydrocannabinol (THC) and Cannabidiol (CBD) are widening. However, the oral consumption of the molecules is very limited due to their highly lipophilic nature that leads to poor solubility at the aqueous environment. Additionally, THC and CBD are prone to extensive first pass mechanisms. These absorption obstacles render the molecules with low and variable oral bioavailability. To overcome these limitations we designed and developed the advanced pro-nanolipospheres (PNL) formulation...
September 8, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28888984/cannabidiol-a-novel-inverse-agonist-for-gpr12
#13
Kevin J Brown, Alyssa S Laun, Zhao-Hui Song
GPR12 is a constitutively active, Gs protein-coupled receptor that currently has no confirmed endogenous ligands. GPR12 may be involved in physiological processes such as maintenance of oocyte meiotic arrest and brain development, as well as pathological conditions such as metastatic cancer. In this study, the potential effects of various classes of cannabinoids on GPR12 were tested using a cAMP accumulation assay. Our data demonstrate that cannabidiol (CBD), a major non-psychoactive phytocannabinoid, acted as an inverse agonist to inhibit cAMP accumulation stimulated by the constitutively active GPR12...
September 6, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28885457/cannabis-constituent-synergy-in-a-mouse-neuropathic-pain-model
#14
Sherelle L Casey, Nicholas Atwal, Christopher W Vaughan
Cannabis and its psychoactive constituent Δ9-tetrahydrocannabinol (THC) have efficacy against neuropathic pain however, this is hampered by their side-effects. It has been suggested that co-administration with another major constituent cannabidiol (CBD) might enhance the analgesic actions of THC and minimise its deleterious side-effects. We examined the basis for this phytocannabinoid interaction in a mouse chronic constriction injury (CCI) model of neuropathic pain. Acute systemic administration of THC dose-dependently reduced CCI-induced mechanical and cold allodynia, but also produced motor incoordination, catalepsy and sedation...
September 1, 2017: Pain
https://www.readbyqxmd.com/read/28885454/attenuation-of-early-phase-inflammation-by-cannabidiol-prevents-pain-and-nerve-damage-in-rat-osteoarthritis
#15
Holly T Philpott, Melissa O'Brien, Jason J McDougall
Osteoarthritis (OA) is a multifactorial joint disease, which includes joint degeneration, intermittent inflammation, and peripheral neuropathy. Cannabidiol (CBD) is a non-euphoria producing constituent of cannabis that has the potential to relieve pain. The aim of this study was to determine if CBD is anti-nociceptive in OA, and whether inhibition of inflammation by CBD could prevent the development of OA pain and joint neuropathy. OA was induced in male Wistar rats (150-175g) by intra-articular injection of sodium monoiodoacetate (MIA; 3mg)...
September 1, 2017: Pain
https://www.readbyqxmd.com/read/28883699/minor-endoscopic-sphincterotomy-followed-by-large-balloon-dilation-for-large-choledocholith-treatment
#16
Xiao-Dan Xu, Bo Chen, Jian-Jun Dai, Jian-Qing Qian, Chun-Fang Xu
AIM: To evaluate early and late outcomes of endoscopic papillary large balloon dilation (EPLBD) with minor endoscopic sphincterotomy (mEST) for stone removal. METHODS: A total of 149 consecutive patients with difficult common bile duct (CBD) stones (diameter ≥ 10 mm or ≥ 3 stones) underwent conventional endoscopic sphincterotomy (EST) or mEST plus EPLBD from May 2012 to April 2016. Their demographic, laboratory and procedural data were collected, and pancreaticobiliary complications were recorded...
August 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28883488/integrated-method-to-attach-dna-handles-and-functionally-select-proteins-to-study-folding-and-protein-ligand-interactions-with-optical-tweezers
#17
Yuxin Hao, Clare Canavan, Susan S Taylor, Rodrigo A Maillard
Optical tweezers has emerged as a powerful tool to study folding, ligand binding, and motor enzymes. The manipulation of proteins with optical tweezers requires attaching molecular handles to the protein of interest. Here, we describe a novel method that integrates the covalent attachment of DNA handles to target proteins with a selection step for functional and properly folded molecules. In addition, this method enables obtaining protein molecules in different liganded states and can be used with handles of different lengths...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28883388/retrospective-clinical-study-of-the-effects-of-t-tube-placement-for-bile-duct-stricture
#18
İbrahim Tayfun Şahiner, Murat Kendirci
BACKGROUND T-tube placement in the common bile duct (CBD) is a surgical alternative to bile duct reconstruction in cholecystectomy for cholecysto-choledocholithiasis, or gallstones. The aim of this retrospective clinical study was to investigate the incidence of late complications of T-tube placement. MATERIAL AND METHODS Retrospective review identified 35 patients who had T-tube placement during cholecystectomy. Clinical data were collected on surgical indications, patient demographics, and clinical symptoms...
September 8, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28882919/a-randomised-controlled-cross-over-double-blind-pilot-study-protocol-on-thc-cbd-oromucosal-spray-efficacy-as-an-add-on-therapy-for-post-stroke-spasticity
#19
Lucio Marinelli, Maurizio Balestrino, Laura Mori, Luca Puce, Gian Marco Rosa, Laura Giorello, Antonio Currà, Francesco Fattapposta, Carlo Serrati, Carlo Gandolfo, Giovanni Abbruzzese, Carlo Trompetto
INTRODUCTION: Stroke is the most disabling neurological disorder and often causes spasticity. Transmucosal cannabinoids (tetrahydrocannabinol and cannabidiol (THC:CBD), Sativex) is currently available to treat spasticity-associated symptoms in patients with multiple sclerosis. Cannabinoids are being considered useful also in the treatment of pain, nausea and epilepsy, but may bear and increased risk for cardiovascular events. Spasticity is often assessed with subjective and clinical rating scales, which are unable to measure the increased excitability of the monosynaptic reflex, considered the hallmark of spasticity...
September 7, 2017: BMJ Open
https://www.readbyqxmd.com/read/28881992/image-based-spatiotemporal-causality-inference-for-protein-signaling-networks
#20
Xiongtao Ruan, Christoph Wülfing, Robert F Murphy
Motivation: Efforts to model how signaling and regulatory networks work in cells have largely either not considered spatial organization or have used compartmental models with minimal spatial resolution. Fluorescence microscopy provides the ability to monitor the spatiotemporal distribution of many molecules during signaling events, but as of yet no methods have been described for large scale image analysis to learn a complex protein regulatory network. Here we present and evaluate methods for identifying how changes in concentration in one cell region influence concentration of other proteins in other regions...
July 15, 2017: Bioinformatics
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