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https://www.readbyqxmd.com/read/28326468/day-case-laparoscopic-cholecystectomy-analysis-of-the-factors-allowing-early-discharge
#1
Giovanni Domenico Tebala, Angela Belvedere, Sean Keane, Abdul Qayyum Khan, Abdelsalam Osman
Despite a number of studies have already demonstrated that majority of patients can be safely discharged early after laparoscopic cholecystectomy, this approach did not gain widespread diffusion yet. The present study was set up to assess safety and feasibility of 24 h or same-day discharge after laparoscopic cholecystectomy and to identify the prognostic factors. Perioperative variables of 229 patients undergoing cholecystectomy have been analyzed. Primary endpoints were: postoperative length of stay, rate of patients discharged within 24 h, and rate of those discharged on the same day...
March 21, 2017: Updates in Surgery
https://www.readbyqxmd.com/read/28293911/delta-9-tetrahydrocannabinol-cannabidiol-oromucosal-spray-sativex-%C3%A2-a-review-in-multiple-sclerosis-related-spasticity
#2
Gillian M Keating
Delta-9-tetrahydrocannabinol (THC)/cannabidiol (CBD) oromucosal spray (THC/CBD, Sativex(®), nabiximols) is available in numerous countries worldwide for the treatment of multiple sclerosis (MS)-related moderate to severe spasticity in patients who have not responded adequately to other anti-spasticity medication and who demonstrate clinically significant improvement in spasticity-related symptoms during an initial trial of therapy. Twelve weeks' therapy with THC/CBD improved MS-related spasticity in patients with an inadequate response to other anti-spasticity agents who had undergone a successful initial trial of THC/CBD therapy, according to the results of a pivotal phase 3 trial...
March 14, 2017: Drugs
https://www.readbyqxmd.com/read/28289391/cannabidiol-affects-mk-801-induced-changes-in-the-ppi-learned-response-of-capuchin-monkeys-sapajus-spp
#3
Patricia G Saletti, Rafael S Maior, Marilia Barros, Hisao Nishijo, Carlos Tomaz
There are several lines of evidence indicating a possible therapeutic action of cannabidiol (CBD) in schizophrenia treatment. Studies with rodents have demonstrated that CBD reverses MK-801 effects in prepulse inhibition (PPI) disruption, which may indicate that CBD acts by improving sensorimotor gating deficits. In the present study, we investigated the effects of CBD on a PPI learned response of capuchin monkeys (Sapajus spp.). A total of seven monkeys were employed in this study. In Experiment 1, we evaluated the CBD (doses of 15, 30, 60 mg/kg, i...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28286481/a-systematic-review-and-meta-analysis-of-the-haemodynamic-effects-of-cannabidiol
#4
Salahaden R Sultan, Sophie A Millar, Timothy J England, Saoirse E O'Sullivan
Despite cannabidiol (CBD) having numerous cardiovascular effects in vitro, its haemodynamic effects in vivo are unclear. Nonetheless, the clinical use of CBD (Epidiolex) is becoming more widespread. The aim of this systematic review was to establish whether CBD is associated with changes in haemodynamics in vivo. Twenty-five studies that assessed the haemodynamic effects of CBD (from PubMed, Medline and EMBASE) were systematically reviewed and meta-analyzed. Data on blood pressure (BP), heart rate (HR), and blood flow (BF) were extracted and analyzed using random effects models...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28279776/outcomes-of-laparoscopic-vs-open-common-bile-duct-exploration-analysis-of-the-nsqip-database
#5
Hamzeh M Halawani, Hani Tamim, Farah Khalifeh, Aurélie Mailhac, Ali Taher, Jamal Hoballah, Faek R Jamali
BACKGROUND: Common bile duct exploration (CBDE) is one of the available options in the management of choledocholithiasis. We aim to analyze outcomes comparing the laparoscopic and open approach to CBDE using the American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) database. STUDY DESIGN: This is a retrospective cohort study of patients undergoing CBDE from year 2008 to 2013 using ACS NSQIP database. The cohort was split into 2 groups and compared based on the operative approach, laparoscopic versus open CBDE...
March 6, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28278035/validation-of-temporal-and-spatial-consistency-of-facility-and-speed-specific-vsp-distribution-for-emission-estimation-a-case-study-in-beijing
#6
Zhiqiang Zhai, Guohua Song, Hongyu Lu, Weinan He, Lei Yu
Vehicle specific power (VSP) has been found to be highly correlated with vehicle emissions. It is used in many studies on emissions modeling such as the MOVES model. The existing studies develop specific VSP distributions (or OpMode distribution in MOVES) for different road types and various average speeds to represent the vehicle operating modes on road. However, it is still not clear if the facility- and speed-specific VSP distributions are consistent temporally and spatially. For instance, is it necessary to update periodically the database of the VSP distributions in the emission model? Are the VSP distributions developed in the city CBD area applicable to its suburb area? In this context, this study examined the temporal and spatial consistency of the facility- and speed-specific VSP distributions in Beijing...
February 22, 2017: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/28276775/cannabinoids-therapeutic-use-what-is-our-current-understanding-following-the-introduction-of-thc-thc-cbd-oromucosal-spray-and-others
#7
Mauro Maccarrone, Rafael Maldonado, Miguel Casas, Thomas Henze, Diego Centonze
The complexity of the endocannabinoid (eCB) system is becoming better understood and new drivers of eCB signaling are emerging. Modulation of the activities of the eCB system can be therapeutic in a number of diseases. Research into the eCB system has been paralleled by the development of agents that interact with cannabinoid receptors. In this regard it should be remembered that herbal cannabis contains a myriad of active ingredients, and the individual cannabinoids have quite distinct biological activities requiring independent studies...
February 28, 2017: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/28275087/community-health-workers-as-social-marketers-of-injectable-contraceptives-a-case-study-from-ethiopia
#8
REVIEW
Karen Weidert, Amanuel Gessessew, Suzanne Bell, Hagos Godefay, Ndola Prata
Ethiopia has made notable progress in increasing awareness and knowledge of family planning and is considered a success story among funders and program planners. Yet unmet need among rural women (28.6%) is almost double that of urban women (15.5%), with a wide gap in total fertility rate depending on urban (2.6) or rural (5.5) residence. This study investigates the impact of a service delivery model that combines community-based distribution (CBD) of contraception with social marketing in Tigray, Ethiopia, to create a more sustainable approach to CBD...
March 8, 2017: Global Health, Science and Practice
https://www.readbyqxmd.com/read/28271184/shared-genetic-risk-between-corticobasal-degeneration-progressive-supranuclear-palsy-and-frontotemporal-dementia
#9
Jennifer S Yokoyama, Celeste M Karch, Chun C Fan, Luke W Bonham, Naomi Kouri, Owen A Ross, Rosa Rademakers, Jungsu Kim, Yunpeng Wang, Günter U Höglinger, Ulrich Müller, Raffaele Ferrari, John Hardy, Parastoo Momeni, Leo P Sugrue, Christopher P Hess, A James Barkovich, Adam L Boxer, William W Seeley, Gil D Rabinovici, Howard J Rosen, Bruce L Miller, Nicholas J Schmansky, Bruce Fischl, Bradley T Hyman, Dennis W Dickson, Gerard D Schellenberg, Ole A Andreassen, Anders M Dale, Rahul S Desikan
Corticobasal degeneration (CBD), progressive supranuclear palsy (PSP) and a subset of frontotemporal dementia (FTD) are neurodegenerative disorders characterized by tau inclusions in neurons and glia (tauopathies). Although clinical, pathological and genetic evidence suggests overlapping pathobiology between CBD, PSP, and FTD, the relationship between these disorders is still not well understood. Using summary statistics (odds ratios and p values) from large genome-wide association studies (total n = 14,286 cases and controls) and recently established genetic methods, we investigated the genetic overlap between CBD and PSP and CBD and FTD...
March 7, 2017: Acta Neuropathologica
https://www.readbyqxmd.com/read/28267133/recent-advances-in-the-pathophysiology-of-arterial-hypertension-potential-implications-for-clinical-practice
#10
Dagmara Hering, Andrzej Trzebski, Krzysztof Narkiewicz
Hypertension remains a major and growing public health problem associated with the greatest proportion of global cardiovascular (CV) morbidity and mortality. Although numerous factors contribute to poor blood pressure (BP) control and pseudo-resistance (i.e. unawareness, life-style habits, non-adherence to medication, insufficient treatment, drug-induced hypertension, undiagnosed secondary causes etc.), it is reported that true resistant hypertension (RH) is found in 10.1 % of patients treated for elevated BP...
March 1, 2017: Pol Arch Intern Med
https://www.readbyqxmd.com/read/28260776/distal-common-bile-duct-tuberculosis-with-obstructive-jaundice-a-case-report
#11
M M Chowdhury, A K Ullah, M J Hossain, S Mohammed, S M Towhid, S A Sobhan, Z H Khan, F Jannat, M H Kabir
Tuberculosis (TB) isolated in Common Bile Duct (CBD) is very rare and its treatment is somewhat controversial. We report a case of distal CBD tuberculosis diagnosed as cholangiocarcinoma. A 40 year old man presented with obstructive jaundice without abdominal pain, fever or weight loss. Ultrasonography and Magnetic Resonance Cholangio-Pancreatography (MRCP) indicated a mass lesion in the Distal CBD, which caused structure of the distal common bile duct. As Cholangiocarcinoma was suspected, he underwent Whipple procedure (pancreaticoduodenectomy)...
January 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28259709/consensus-classification-of-posterior-cortical-atrophy
#12
Sebastian J Crutch, Jonathan M Schott, Gil D Rabinovici, Melissa Murray, Julie S Snowden, Wiesje M van der Flier, Bradford C Dickerson, Rik Vandenberghe, Samrah Ahmed, Thomas H Bak, Bradley F Boeve, Christopher Butler, Stefano F Cappa, Mathieu Ceccaldi, Leonardo Cruz de Souza, Bruno Dubois, Olivier Felician, Douglas Galasko, Jonathan Graff-Radford, Neill R Graff-Radford, Patrick R Hof, Pierre Krolak-Salmon, Manja Lehmann, Eloi Magnin, Mario F Mendez, Peter J Nestor, Chiadi U Onyike, Victoria S Pelak, Yolande Pijnenburg, Silvia Primativo, Martin N Rossor, Natalie S Ryan, Philip Scheltens, Timothy J Shakespeare, Aida Suárez González, David F Tang-Wai, Keir X X Yong, Maria Carrillo, Nick C Fox
INTRODUCTION: A classification framework for posterior cortical atrophy (PCA) is proposed to improve the uniformity of definition of the syndrome in a variety of research settings. METHODS: Consensus statements about PCA were developed through a detailed literature review, the formation of an international multidisciplinary working party which convened on four occasions, and a Web-based quantitative survey regarding symptom frequency and the conceptualization of PCA...
March 1, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28254350/the-current-status-of-artisanal-cannabis-for-the-treatment-of-epilepsy-in-the-united-states
#13
Dustin Sulak, Russell Saneto, Bonni Goldstein
The widespread patient use of artisanal cannabis preparations has preceded quality validation of cannabis use for epilepsy. Neurologists and cannabinoid specialists are increasingly in a position to monitor and guide the use of herbal cannabis in epilepsy patients. We report the retrospective data on efficacy and adverse effects of artisanal cannabis in Patients with medically refractory epilepsy with mixed etiologies in Washington State, California, and Maine. Clinical considerations, including potential risks and benefits, challenges related to artisanal preparations, and cannabinoid dosing, are discussed...
February 18, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28251501/appropriate-patient-selection-is-essential-for-the-success-of-primary-closure-after-laparoscopic-common-bile-duct-exploration
#14
Shun-Qian Wen, Qiu-Hui Hu, Ming Wan, Sheng Tai, Xue-Yi Xie, Qing Wu, Shang-Lin Yang, Guan-Qun Liao
BACKGROUND: Laparoscopic common bile duct exploration (LCBDE) is being increasingly used for management of common bile duct (CBD) stones. Primary CBD closure has been reported to have better short-term outcomes compared to T-tube placement. However, primary CBD closure cannot be performed in all patients. AIM: This study aims to evaluate the short- and long-term outcomes of LCBDE with primary CBD closure in appropriately selected patients and compare them with T-tube drainage...
March 1, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28250664/potential-of-cannabidiol-for-the-treatment-of-viral-hepatitis
#15
Henry I C Lowe, Ngeh J Toyang, Wayne McLaughlin
Viral hepatitis B (HBV) and hepatitis C (HCV) pose a major health problem globally and if untreated, both viruses lead to severe liver damage resulting in liver cirrhosis and cancer. While HBV has a vaccine, HCV has none at the moment. The risk of drug resistance, combined with the high cost of current therapies, makes it a necessity for cost-effective therapeutics to be discovered and developed. The recent surge in interest in Medical Cannabis has led to interest in evaluating and validating the therapeutic potentials of Cannabis and its metabolites against various diseases including viruses...
January 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28249817/the-direct-actions-of-cannabidiol-and-2-arachidonoyl-glycerol-at-gabaa-receptors
#16
T Bakas, P S van Nieuwenhuijzen, S O Devenish, I S McGregor, J C Arnold, M Chebib
Cannabidiol (CBD) is a major non-intoxicating component of cannabis and possesses anti-epileptic, anxiolytic and anti-hyperalgesic properties. The mechanism of action of CBD in producing such effects remains unclear. Despite evidence that some endogenous and synthetic cannabinoids interact with GABAA receptors, no-one has yet investigated the effects of CBD. Here we used two-electrode voltage clamp electrophysiology to compare the actions of CBD with those of the major central endocannabinoid, 2-arachidonoyl glycerol (2-AG) on human recombinant GABAA receptors (synaptic α1-6βγ2 and extrasynaptic α4β2δ) expressed on Xenopus oocytes...
February 27, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28245177/%C3%AE-9-tetrahydrocannabinol-decreases-willingness-to-exert-cognitive-effort-in-male-rats
#17
Mason M Silveira, Wendy K Adams, Maria Morena, Matthew N Hill, Catharine A Winstanley
BACKGROUND: Acceptance of cannabis use is growing. However, prolonged use is associated with diminished psychosocial outcomes, potentially mediated by drug-induced cognitive impairments. Δ(9)-Tetrahydrocannabinol (THC) is the main psychoactive ingredient in cannabis, yet other phytocannabinoids in the plant, such as cannabidiol (CBD), have unique properties. Given that CBD can modulate the undesirable effects of THC, therapeutic agents, such as nabiximols, contain higher CBD:THC ratios than illicit marijuana...
March 2017: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/28243754/differentiation-of-atypical-parkinson-syndromes
#18
REVIEW
Günter U Höglinger, Jan Kassubek, Ilona Csoti, Reinhard Ehret, Heinz Herbst, Ingmar Wellach, Jürgen Winkler, Wolfgang H Jost
In distinction to idiopathic Parkinson's disease (PD), the diagnosis of atypical Parkinson syndromes comprises dementia with Lewy bodies (DLB), multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD). We set out to write a state-of-the-art guideline as to which investigations and examinations help to differentiate PD vs. atypical Parkinson syndromes in clinical routine.
February 27, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28243567/performance-of-natural-dye-sensitized-solar-cells-by-zno-nanorod-and-nanowall-enhanced-photoelectrodes
#19
Saif Saadaoui, Mohamed Aziz Ben Youssef, Moufida Ben Karoui, Rached Gharbi, Emanuele Smecca, Vincenzina Strano, Salvo Mirabella, Alessandra Alberti, Rosaria A Puglisi
In this work, two natural dyes extracted from henna and mallow plants with a maximum absorbance at 665 nm were studied and used as sensitizers in the fabrication of dye-sensitized solar cells (DSSCs). Fourier transform infrared (FTIR) spectra of the extract revealed the presence of anchoring groups and coloring constituents. Two different structures were prepared by chemical bath deposition (CBD) using zinc oxide (ZnO) layers to obtain ZnO nanowall (NW) or nanorod (NR) layers employed as a thin film at the photoanode side of the DSSC...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/28236578/social-correlates-of-health-status-quality-of-life-and-mood-states-in-patients-treated-with-cannabidiol-for-epilepsy
#20
Magdalena Szaflarski, Barbara Hansen, E Martina Bebin, Jerzy P Szaflarski
Social characteristics, such as socioeconomic status and race/ethnicity, play a role in the treatment and outcomes of patients with epilepsy (PWE), but little is known about how these factors affect patients receiving cannabidiol (CBD) to treat seizures. This exploratory study examined the sociodemographic profile of patients treated with CBD (n=80) and associations between social factors and patient-centered outcomes - overall health status, Quality of Life in Epilepsy-89 (QOLIE-89), and Profile of Mood States (POMS) - in this population...
February 21, 2017: Epilepsy & Behavior: E&B
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