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Viable allograft

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https://www.readbyqxmd.com/read/29750137/posterior-only-stabilization-for-traumatic-thoracolumbar-burst-fractures
#1
Omid R Hariri, Samir Kashyap, Ariel Takayanagi, Chris Elia, Quang Ma, Dan E Miulli
Background No consensus exists for the management of unstable thoracolumbar (TL) burst fractures. Surgical options include anterior, lateral, or posterior stabilization (or a combination), depending on the fracture. The potential benefits of anterior reconstruction come with increased operative time and associated morbidity. A posterior-only approach can offer stable correction without increased operative risks but may result in loss of kyphotic correction over time. Purpose To determine whether posterior-only stabilization is a viable treatment option for patients with traumatic TL fractures as opposed to anterior and combined approaches...
March 9, 2018: Curēus
https://www.readbyqxmd.com/read/29699850/donor-predicted-heart-mass-as-predictor-of-primary-graft-dysfunction
#2
Timothy A Gong, Susan M Joseph, Brian Lima, Gonzalo V Gonzalez-Stawinski, Aayla K Jamil, Joost Felius, Huanying Qin, Giovanna Saracino, Aldo E Rafael, Parag Kale, Shelley A Hall
BACKGROUND: Concern over the hazards associated with undersized donor hearts has impeded the utilization of otherwise viable allografts for transplantation. Previous studies have indicated predicted heart mass (PHM) may provide better size matching in cardiac transplantation than total body weight (TBW). We investigated whether size-matching donor hearts by PHM is a better predictor of primary graft dysfunction (PGD) than matching by TBW. METHODS: Records of consecutive adult cardiac transplants performed between 2012 and 2016 at a single-center academic hospital were reviewed...
March 17, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29644033/a-case-of-dupuytren-s-disease-managed-with-viable-cryopreserved-placental-membrane-adjunct-to-open-palmar-fasciectomy
#3
Christopher M Dress, Elisabet K Tassis
Dupuytren's disease (DD) is a rare connective tissue disorder resulting in progressive fibrosis and thickening of the palmar fascia, and contracture of the fingers due to excessive collagen deposition. Staged surgical interventions are reserved for severe cases, yet worsening of fibrosis and contracture of fingers post-surgery, has been reported to have a recurrence rate as high as 85%. Here, the authors report on use of viable cryopreserved placental membrane (vCPM) allograft as an adjunct to open fasciectomy...
March 2018: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29595532/development-of-an-ex-situ-limb-perfusion-system-for-a-rodent-model
#4
Emre Gok, Fares Alghanem, Ruth Moon, Erin Guy, Alvaro Rojas-Pena, Robert H Bartlett, Kagan Ozer
Ex-situ perfusion (ESP) is a promising method in preserving vascularized composite tissue allografts (VCAs) with potential to widen donor procurement to larger geographic areas. To optimize the method of preservation, we developed a small animal model to conduct biomolecular investigations. Twenty rat hind limbs (18.2 ± 1.3 g) were procured and connected to our custom-made ESP system. Perfusion pressure and flow parameters were measured with hourly blood gas analysis under near-normothermic (30-35˚C) conditions...
March 26, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29584608/utilization-of-a-viable-human-amnion-membrane-allograft-in-elderly-patients-with-chronic-lower-extremity-wounds-of-various-etiologies
#5
Matthew Regulski
ntroduction. Chronic nonhealing wounds are a growing health care problem in the United States, afflicting more than 6.5 million patients annually. In particular, diseases that compromise skin integrity and impair normal wound healing processes, such as diabetes and peripheral vascular diseases, are becoming more common in the aging population and leading to ever-increasing incidence of these chronic nonhealing wounds. OBJECTIVE: The aim of this study is to evaluate a viable human amnion membrane allograft (vHAMA) for the treatment of chronic nonhealing wounds in elderly patients (aged > 65 years) with multiple comorbidities...
March 2018: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29575268/revitalized-and-synovialized-allograft-for-intrasynovial-flexor-tendon-reconstruction-in-an-in-vivo-canine-model
#6
Tao Zhang, Cheng-Chang Lu, Ramona L Reisdorf, Andrew R Thoreson, Anne Gingery, Steven L Moran, Peter C Amadio, Chunfeng Zhao
This study was to test our hypothesis that flexor tendon reconstruction with an allograft revitalized with bone marrow stromal cells (BMSCs) and synovialized with carbodiimide derivatized autologous synovial fluid (cd-SYN) would result in better digit functional restoration than the conventional allograft tendon. Thirty-two flexor digital profundus tendons from the second and fifth digit of 16 dogs were created a repair failure model first. Then, failed-repaired tendons were reconstructed with either a revitalized-synovialized allograft tendon or a clinical standard autograft tendon (control group)...
March 25, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29573913/fresh-osteochondral-allograft-transplantation-for-treatment-of-large-cartilage-defects-of-the-femoral-head-a-minimum-two-year-follow-up-study-of-twenty-two-patients
#7
Xin Y Mei, Ibrahim S Alshaygy, Oleg A Safir, Allan E Gross, Paul R Kuzyk
BACKGROUND: Controversy remains over the surgical management of large osteochondral lesions of the femoral head in young, active patients. The purpose of this study is to assess midterm clinical and radiographic outcomes after fresh osteochondral allograft transplantation (OAT) for large femoral head lesions at minimum 2-year follow-up. METHODS: A retrospective review of prospectively collected data was performed for 22 patients under the age of 50 years with defined femoral head osteochondral lesions who underwent fresh OAT between 2008 and 2015...
February 9, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29559375/contemporary-outcomes-of-ecmo-used-as-bridge-to-lung-transplantation
#8
Ali H Hakim, Usman Ahmad, Kenneth R McCurry, Douglas R Johnston, Gosta B Pettersson, Marie Budev, Sudish Murthy, Eugene H Blackstone, Michael Z Tong
BACKGROUND: Extracorporeal membrane oxygenation (ECMO), when used as bridge to lung transplantation (BTT) identifies high-risk candidates. Recent advances in cannula design and patient selection fosters "awake ambulatory ECMO" as a viable option for critically ill candidates in an attempt to retard deconditioning while awaiting allografts. METHODS: From 2012 to 2015, 30 patients underwent ECMO as BTT. Candidacy for ECMO was determined prior to listing for transplant...
March 17, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29552571/septic-arthritis-after-anterior-cruciate-ligament-reconstruction-clinical-and-functional-outcomes-based-on-graft-retention-or-removal
#9
Brian R Waterman, William Arroyo, Eric J Cotter, Michael A Zacchilli, E'Stephan J Garcia, Brett D Owens
Background: There remains a debate over whether to retain the index anterior cruciate ligament (ACL) graft in the setting of septic arthritis. Purpose: To evaluate and compare clinical outcomes for the treatment of septic arthritis after ACL reconstruction (ACLR) in those with and without early graft retention. Study Design: Case series; Level of evidence, 4. Methods: The Military Health System was queried for all ACLR procedures performed between 2007 and 2013...
March 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29547951/anterior-reduction-and-fusion-of-cervical-facet-dislocations
#10
Christian B Theodotou, George M Ghobrial, Andrew L Middleton, Michael Y Wang, Allan D Levi
BACKGROUND: Cervical facet dislocations are among the most common traumatic spinal injuries. Posterior, anterior, and combined surgical approaches have been described and are widely debated. OBJECTIVE: To demonstrate efficacy in anterior-only surgical management for subaxial cervical facet dislocations. METHODS: A consistent surgical algorithm for cervical facet dislocation was applied over a 19-yr period and analyzed retrospectively in adults with acute unilateral or bilateral facet dislocation of the subaxial cervical spine...
March 14, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29547626/clinical-management-and-outcomes-of-patients-with-hermansky-pudlak-syndrome-pulmonary-fibrosis-evaluated-for-lung-transplantation
#11
Souheil El-Chemaly, Kevin J O'Brien, Steven D Nathan, Gerald L Weinhouse, Hilary J Goldberg, Jean M Connors, Ye Cui, Todd L Astor, Philip C Camp, Ivan O Rosas, Merte Lemma, Vladislav Speransky, Melissa A Merideth, William A Gahl, Bernadette R Gochuico
Pulmonary fibrosis is a progressive, fatal manifestation of Hermansky-Pudlak syndrome (HPS). Some patients with advanced HPS pulmonary fibrosis undergo lung transplantation despite their disease-associated bleeding tendency; others die while awaiting donor organs. The objective of this study is to determine the clinical management and outcomes of a cohort with advanced HPS pulmonary fibrosis who were evaluated for lung transplantation. Six patients with HPS-1 pulmonary fibrosis were evaluated at the National Institutes of Health Clinical Center and one of two regional lung transplant centers...
2018: PloS One
https://www.readbyqxmd.com/read/29515701/cryopreserved-human-allografts-for-the-reconstruction-of-aortic-and-peripheral-prosthetic-graft-infection
#12
Matteo Bossi, Matteo Tozzi, Marco Franchin, Stefania Ferraro, Nicola Rivolta, Massimo Ferrario, Chiara Guttadauro, Patrizio Castelli, Gabriele Piffaretti
Background : This study aimed to present cases with cryopreserved human allografts (CHAs) for vascular reconstruction in both aortic and peripheral infected prosthetic grafts. Materials and Methods : This is a single center, observational descriptive study with retrospective analysis. In all cases, the infected prosthetic graft material was completely removed. At discharge, patients were administered anticoagulants. Follow-up examinations included clinical visits, echo-color-Doppler ultrasounds, or computed tomography angiography within 30 days and at 3, 6, and 12 months after the treatment, and then twice per year...
December 25, 2017: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/29514363/comparison-of-techniques-for-preimplantation-treatment-of-osteochondral-allograft-bone
#13
Charles A Baumann, John R Baumann, Chantelle C Bozynski, Aaron M Stoker, James P Stannard, James L Cook
Articular defects are a major problem with few effective treatment options. Osteochondral allograft (OCA) transplantation can be an effective treatment; however, lack of OCA bone integration can cause failure. This controlled laboratory study was designed to compare clinically applicable methods for marrow element removal and enhanced delivery of bone marrow aspirate concentrate (BMC) to OCA bone. We hypothesized that compressed carbon dioxide (CO2 ) treatment of OCA bone would result in significantly better marrow element removal, significantly more retention and distribution of viable osteoprogenitor cells, and significantly higher osteoinductive protein elution from OCAs compared with other preimplantation treatments...
March 7, 2018: Journal of Knee Surgery
https://www.readbyqxmd.com/read/29514217/downsized-cryopreserved-and-standard-sized-allografts-for-right-ventricular-outflow-tract-reconstruction-in-children-long-term-single-institutional-experience
#14
Jamie L R Romeo, Grigorios Papageorgiou, Pieter C van de Woestijne, Johanna J M Takkenberg, Lauren E H Westenberg, Ingrid van Beynum, Ad J J C Bogers, Mostafa M Mokhles
OBJECTIVES: The objective of this study was to determine long-term results with bicuspidalized allografts compared to non-bicuspidalized allografts in children under 2 years undergoing primary correction of the right ventricular outflow tract. METHODS: Thirty-five consecutive bicuspidalized allografts were compared to 45 consecutive non-bicuspidalized allografts implanted during the same period. Valve-related events were analysed with Kaplan-Meier and Cox-regression techniques...
March 3, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29511673/structural-and-morselized-allografting-combined-with-a-cementless-cup-for-acetabular-defects-in-revision-total-hip-arthroplasty-a-4-to-14-year-follow-up
#15
Hou-Tsung Chen, Cheng-Ta Wu, Tsan-Wen Huang, Hsin-Nung Shih, Jun-Wen Wang, Mel S Lee
Using morselized and structural allograft to restore bone stock for massive acetabular bone defect in revision total hip arthroplasty (THA) is an appealing procedure. However, concerns about inability to achieve long-term stability following allograft resorption remained. From 2003 to 2012, 59 hips in 58 patients undergoing revision THA for Paprosky type II or III acetabular defects were retrospectively reviewed. The acetabular defects were managed with deep-frozen morselized and structural allografts, and a press-fit cementless cup along with supplementary screws...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29506828/effect-of-the-vascularized-bone-components-on-the-survival-of-vascularized-composite-allografts
#16
Jianwu Chen, Dongliang Zhang, Tao Zhang, Chen Chen, Yajuan Song, Shiqiang Liu, Yingjun Su, Shuzhong Guo
BACKGROUND: Vascularized composite allograft (VCA), such as hand and face allograft, contains a vascularized bone component that may provide an immunologic benefit and induce tolerance for the simultaneous inclusion of marrow cells and a marrow microenvironment. We developed a chimeric groin cutaneous/femur flap to investigate the effect of vascularized bone marrow on VCA survival and its ability to induce chimerism. METHODS: Brown Norway and Lewis rats were used as donors and recipients, respectively...
April 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29499866/donor-tissue-specific-exosome-profiling-enables-noninvasive-monitoring-of-acute-rejection-in-mouse-allogeneic-heart-transplantation
#17
Andreas Habertheuer, Laxminarayana Korutla, Susan Rostami, Sanjana Reddy, Priti Lal, Ali Naji, Prashanth Vallabhajosyula
OBJECTIVE: In heart transplantation, there is a critical need for development of biomarkers to noninvasively monitor cardiac allografts for immunologic rejection or injury. Exosomes are tissue-specific nanovesicles released into circulation by many cell types. Their profiles are dynamic, reflecting conditional changes imposed on their tissue counterparts. We proposed that a transplanted heart releases donor-specific exosomes into the recipient's circulation that are conditionally altered during immunologic rejection...
February 1, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29492380/outcomes-and-survival-following-heart-retransplantation-for-cardiac-allograft-failure-a-systematic-review-and-meta-analysis
#18
REVIEW
Syed-Saif Abbas Rizvi, Jessica G Y Luc, Jae Hwan Choi, Kevin Phan, Ester Moncho Escrivà, Sinal Patel, H Todd Massey, Vakhtang Tchantchaleishvili
Background: Long-term efficacy of heart retransplantation (RTx) for end-stage cardiac allograft failure remains unclear given the limited worldwide experience and is an important question to elucidate given the shortage of donor organs. The aim of this systematic review was to examine the outcomes of RTx in patients with cardiac allograft failure. Methods: Electronic search was performed to identify all studies in the English literature assessing RTx for cardiac allograft failure...
January 2018: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29483480/-aortic-root-replacement-with-cryopreserved-allograft-aortic-valve
#19
Haruo Yamauchi, Minoru Ono
Aortic root replacement with a cryopreserved allograft aortic valve is effective for active infectious endocarditis and prosthetic valve endocarditis, especially with a perivalvular abscess, since an allograft seems to be resistant to infection by maintaining viable cells under the process of programmed freezing. From December 1998 to March 2017, aortic root replacement with allograft aortic valves were performed in 38 patients in the University of Tokyo. The in-hospital mortality was 18%, the 5-year survival rate was 68%, and the 5-year freedom rate of reoperation was 75%...
January 2018: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/29482862/meniscal-allograft-transplantation-the-effect-of-cartilage-status-on-survivorship-and-clinical-outcome
#20
Ahmed Mahmoud, James Young, Joanne Bullock-Saxton, Peter Myers
PURPOSE: To evaluate the survivorship of meniscal allograft transplantations (MATs), their clinical outcomes, and to compare the effect of perioperative cartilage status on survivorship. METHOD: A consecutive series of MATs with a minimum postsurgical time of 4 years were included from a prospectively collected database from 2001 to 2015. Mechanical failure was defined as transplant removal or knee arthroplasty. The effect of peri-operative cartilage status on survivorship was analyzed using a Kaplan-Meier analysis...
February 23, 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
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