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colorectal cancer gut microbiota

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https://www.readbyqxmd.com/read/29770393/consumption-of-pomegranate-decreases-plasma-lipopolysaccharide-binding-protein-levels-a-marker-of-metabolic-endotoxemia-in-patients-with-newly-diagnosed-colorectal-cancer-a-randomized-controlled-clinical-trial
#1
A González-Sarrías, M A Núñez-Sánchez, M A Ávila-Gálvez, T Monedero-Saiz, F J Rodríguez-Gil, Francisco Martínez-Díaz, M V Selma, J C Espín
Gut microbiota dysbiosis alters the intestinal barrier function, increases plasma lipopolysaccharide (LPS) levels, which promotes endotoxemia, and contributes to the onset and development of colorectal cancer (CRC). We report here for the first time the reduction of plasma LPS-binding protein (LBP) levels, a marker of endotoxemia, after pomegranate consumption in newly diagnosed CRC patients.
May 17, 2018: Food & Function
https://www.readbyqxmd.com/read/29731748/oral-bacterial-and-fungal-microbiome-impacts-colorectal-carcinogenesis
#2
REVIEW
Klara Klimesova, Zuzana Jiraskova Zakostelska, Helena Tlaskalova-Hogenova
Host's physiology is significantly influenced by microbiota colonizing the epithelial surfaces. Complex microbial communities contribute to proper mucosal barrier function, immune response, and prevention of pathogen invasion and have many other crucial functions. The oral cavity and large intestine are distant parts of the digestive tract, both heavily colonized by commensal microbiota. Nevertheless, they feature different proportions of major bacterial and fungal phyla, mostly due to distinct epithelial layers organization and different oxygen levels...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29720905/the-role-of-the-gut-microbiome-in-colorectal-cancer
#3
REVIEW
Grace Y Chen
There is increasing evidence that the gut microbiome, which consists of trillions of microbes representing over 1,000 species of bacteria with over 3 million genes, significantly impacts intestinal health and disease. The gut microbiota not only is capable of promoting intestinal homeostasis and antitumor responses but can also contribute to chronic dysregulated inflammation as well as have genotoxic effects that lead to carcinogenesis. Whether the gut microbiota maintains health or promotes colon cancer may ultimately depend on the composition of the gut microbiome and the balance within the microbial community of protective and detrimental bacterial populations...
May 2018: Clinics in Colon and Rectal Surgery
https://www.readbyqxmd.com/read/29713943/the-association-of-diet-gut-microbiota-and-colorectal-cancer-what-we-eat-may-imply-what-we-get
#4
REVIEW
Jia Yang, Jun Yu
Despite the success of colonoscopy screening and recent advances in cancer treatment, colorectal cancer (CRC) still remains one of the most commonly diagnosed and deadly cancers, with a significantly increased incidence in developing countries where people are adapting to Western lifestyle. Diet has an important impact on risk of CRC. Multiple epidemiological studies have suggested that excessive animal protein and fat intake, especially red meat and processed meat, could increase the risk of developing CRC while fiber could protect against colorectal tumorigenesis...
April 30, 2018: Protein & Cell
https://www.readbyqxmd.com/read/29705028/food-microbiome-and-colorectal-cancer
#5
REVIEW
Lukas Niederreiter, Timon E Adolph, Herbert Tilg
You are what you eat. This adage has been confirmed by many studies demonstrating the high impact of nutrition on risk of cardiovascular diseases, many malignancies and other diseases. Dietary factors are of major relevance in the evolution of colorectal carcinoma. Various aspects are involved in colorectal carcinoma pathogenesis including genetics, lifestyle, age, chronic inflammation and others. It has only recently been recognized that the gut microbiota might reflect an important missing link in the interaction between diet and subsequent colorectal carcinoma development...
April 3, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29702299/diets-that-promote-colon-inflammation-associate-with-risk-of-colorectal-carcinomas-that-contain-fusobacterium-nucleatum
#6
Li Liu, Fred K Tabung, Xuehong Zhang, Jonathan A Nowak, Zhi Rong Qian, Tsuyoshi Hamada, Daniel Nevo, Susan Bullman, Kosuke Mima, Keisuke Kosumi, Annacarolina da Silva, Mingyang Song, Yin Cao, Tyler S Twombly, Yan Shi, Hongli Liu, Mancang Gu, Hideo Koh, Wanwan Li, Chunxia Du, Yang Chen, Chenxi Li, Wenbin Li, Raaj S Mehta, Kana Wu, Molin Wang, Aleksander D Kostic, Marios Giannakis, Wendy S Garrett, Curtis Hutthenhower, Andrew T Chan, Charles S Fuchs, Reiko Nishihara, Shuji Ogino, Edward L Giovannucci
BACKGROUND & AIMS: Specific nutritional components are likely to induce intestinal inflammation, which is characterized by increased levels of interleukin 6 (IL6), C-reactive protein (CRP), and TNF receptor superfamily member 1B (TNFRSF1B) in the circulation and promotes colorectal carcinogenesis. The inflammatory effects of a diet can be estimated based on empirical dietary inflammatory pattern (EDIP) score, calculated based on intake of 18 foods associated with plasma levels of IL6, CRP, and TNFRSF1B...
April 24, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29702174/beneficial-effects-of-extracellular-polysaccharide-from-rhizopus-nigricans-on-the-intestinal-immunity-of-colorectal-cancer-mice
#7
Zhidan Yu, Ge Song, Jing Liu, Jiayue Wang, Pengying Zhang, Kaoshan Chen
An extracellular polysaccharide (EPS1-1) extracted from the fermentation broth of Rhizopus nigricans has been proved to enhance the immunity of immunosuppressed mice. The purpose of this study was to investigate the beneficial effects of EPS1-1 on the intestinal immunity of mice with colorectal cancer induced by azoxymethane (AOM) and dextran sodium sulfate (DSS). The results showed that EPS1-1 could resist hydrolysis in an artificial stomach. Oral EPS1-1 modulated gut microbiota and increased the concentration of total short-chain fatty acids (SCFAs) in the feces of colorectal cancer mice compared with the AOM/DSS only-treated mice...
April 24, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29670137/a-systems-biology-approach-to-predict-and-characterize-human-gut-microbial-metabolites-in-colorectal-cancer
#8
QuanQiu Wang, Li Li, Rong Xu
Colorectal cancer (CRC) is the second leading cause of cancer-related deaths. It is estimated that about half the cases of CRC occurring today are preventable. Recent studies showed that human gut microbiota and their collective metabolic outputs play important roles in CRC. However, the mechanisms by which human gut microbial metabolites interact with host genetics in contributing CRC remain largely unknown. We hypothesize that computational approaches that integrate and analyze vast amounts of publicly available biomedical data have great potential in better understanding how human gut microbial metabolites are mechanistically involved in CRC...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29655462/obesity-thrombotic-risk-and-inflammation-in-cancer
#9
Benjamín Rubio-Jurado, Luz-Ma-Adriana Balderas-Peña, Eduardo E García-Luna, María G Zavala-Cerna, Carlos Riebeling-Navarro, Pedro A Reyes, Arnulfo H Nava-Zavala
Neoplasms exhibits a high incidence and mortality rates due to their complex and commonly overlapping clinical, biochemical, and morphologic profiles influenced by acquired or inherited molecular abnormalities, cell of origin, and level of differentiation. Obesity appears related to ~20% of cancers including endometrial, esophageal, colorectal, postmenopausal breast, prostate, and renal. Several factors other than obesity, i.e., insulin, insulin-like growth factor, sexual hormones, and adipokines may play a potential role in neoplasia...
2018: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/29650970/crosstalk-between-gut-microbiota-and-sirtuin-3-in-colonic-inflammation-and-tumorigenesis
#10
Yong Zhang, Xiao-Lan Wang, Min Zhou, Chao Kang, He-Dong Lang, Meng-Ting Chen, Suo-Cheng Hui, Bin Wang, Man-Tian Mi
Colorectal cancer (CRC) is a disease involving a variety of genetic and environmental factors. Sirtuin-3 (Sirt3) is expressed at a low level in cancer tissues of CRC, but it is unclear how Sirt3 modulates colonic tumorigenesis. In this study, we found that gut microbiota play a central role in the resistance to CRC tumor formation in wild-type (WT) mice through APC (Adenomatous Polyposis Coli)-mutant mouse microbiota transfer via Wnt signaling. We also found that Sirt3-deficient mice were hypersusceptible to colonic inflammation and tumor development through altered intestinal integrity and p38 signaling, respectively...
April 13, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29642940/multi-cohort-analysis-of-colorectal-cancer-metagenome-identified-altered-bacteria-across-populations-and-universal-bacterial-markers
#11
Zhenwei Dai, Olabisi Oluwabukola Coker, Geicho Nakatsu, William K K Wu, Liuyang Zhao, Zigui Chen, Francis K L Chan, Karsten Kristiansen, Joseph J Y Sung, Sunny Hei Wong, Jun Yu
BACKGROUND: Alterations of gut microbiota are associated with colorectal cancer (CRC) in different populations and several bacterial species were found to contribute to the tumorigenesis. The potential use of gut microbes as markers for early diagnosis has also been reported. However, cohort specific noises may distort the structure of microbial dysbiosis in CRC and lead to inconsistent results among studies. In this regard, our study targeted at exploring changes in gut microbiota that are universal across populations at species level...
April 11, 2018: Microbiome
https://www.readbyqxmd.com/read/29589305/molecular-analysis-of-the-microbiome-in-colorectal-cancer
#12
Fiona Clegg, Susan H Berry, Richard Hansen, Georgina L Hold
The human gut microbiota plays a major role in the development of colorectal cancer (CRC). Many studies have attempted to define links between microbiota residents, their function and disease development. We now have incredible molecular tools to allow us to study the gut microbiome however in order to make best use of these sophisticated approaches we need to ensure that samples are collected and processed using standardized and reproducible protocols. Here we provide an overview of molecular analysis methods and describe protocols for collecting and processing clinical samples for subsequent microbiome analysis...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29573336/the-impact-of-klebsiella-pneumoniae-in-lower-gastrointestinal-tract-diseases
#13
REVIEW
Christina Parvinder Kaur, Jamuna Vadivelu, Samudi Chandramathi
The 2016 Global Burden of Disease report by WHO revealed that diseases of the gastrointestinal tract had one of the highest incidence rates worldwide. The plethora of factors that contribute to the development of gastrointestinal tract (GIT) related illnesses can be divided into genetic, environmental and lifestyle factors. Apart from that, the role that infectious agents play in the development of GIT diseases has piqued the interest of researchers worldwide. The human gut harbours approximately 101 to 1012 cfu/ml bacteria in it with increasing concentration towards the lower GIT...
March 24, 2018: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/29566907/action-and-function-of-faecalibacterium-prausnitzii-in-health-and-disease
#14
REVIEW
Carmen Veríssima Ferreira-Halder, Alessandra Valéria de Sousa Faria, Sheila Siqueira Andrade
Faecalibacterium prausnitzii, anaerobic bacteria, is one of the main components of gut microbiota and the most important butyrate-producing bacteria in the human colon. So far, this commensal bacterium has been considered as a bioindicator of human health, once when its population is altered (decreased), inflammatory processes are favored. Several reports in the literature highlighted that the amount of Faecalibacterium prausnitzii negatively correlates to the activity of inflammatory bowel disease and colorectal cancer...
December 2017: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/29543545/systematic-review-gut-microbiota-in-fecal-samples-and-detection-of-colorectal-neoplasms
#15
Efrat L Amitay, Agne Krilaviciute, Hermann Brenner
Colorectal cancer (CRC) is a leading cause of cancer morbidity and mortality. Dysbiosis in the gut microbiota may be associated with CRC. This systematic review focuses on differences in gut microbial community between people diagnosed with CRC or adenoma and healthy individuals using fecal samples, emphasizing non-invasive fecal microbiome models for CRC early diagnosis. Nineteen studies were identified in a systematic literature search of Pubmed, Web of Science and ScienceDirect. Several bacteria were reported to differ in abundance between CRC and adenoma cases and healthy controls, with Fusobacterium the most common...
March 15, 2018: Gut Microbes
https://www.readbyqxmd.com/read/29517944/concurrent-gut-transcriptome-and-microbiota-profiling-following-chronic-ethanol-consumption-in-nonhuman-primates
#16
Tasha Barr, Suhas Sureshchandra, Paul Ruegger, Jingfei Zhang, Wenxiu Ma, James Borneman, Kathleen Grant, Ilhem Messaoudi
Alcohol use disorder (AUD) results in increased intestinal permeability, nutrient malabsorption, and increased risk of colorectal cancer (CRC). Our understanding of the mechanisms underlying these morbidities remains limited because studies to date have relied almost exclusively on short-term heavy/binge drinking rodent models and colonic biopsies/fecal samples collected from AUD subjects with alcoholic liver disease (ALD). Consequently, the dose- and site-dependent impact of chronic alcohol consumption in the absence of overt liver disease remains poorly understood...
March 8, 2018: Gut Microbes
https://www.readbyqxmd.com/read/29515527/gut-microbiota-an-integral-moderator-in-health-and-disease
#17
REVIEW
Qingqing Feng, Wei-Dong Chen, Yan-Dong Wang
The gut microbiota, as the main member in gut microecology, is an essential mediator in health and disease. The gut microbiota interacts with various organs and systems in the body, including brain, lung, liver, bone, cardiovascular system, and others. Microbiota-derived metabolites such as the short chain fatty acid (SCFA) butyrate are primary signals, which link the gut microbiota and physiology. Recently, the gut microbiota has been identified as the origin of a number of diseases by influencing the related cell signaling pathways such as WNT/beta-catenin pathway in colorectal cancer and T cell receptor signaling in the central nervous system...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29479437/dysbiosis-of-gut-microbiota-in-promoting-the-development-of-colorectal-cancer
#18
REVIEW
Shaomin Zou, Lekun Fang, Mong-Hong Lee
Gastrointestinal microbiome, containing at least 100 trillion bacteria, resides in the mucosal surface of human intestine. Recent studies show that perturbations in the microbiota may influence physiology and link to a number of diseases, including colon tumorigenesis. Colorectal cancer (CRC), the third most common cancer, is the disease resulting from multi-genes and multi-factors, but the mechanistic details between gut microenvironment and CRC remain poorly characterized. Thanks to new technologies such as metagenome sequencing, progress in large-scale analysis of the genetic and metabolic profile of gut microbial has been possible, which has facilitated studies about microbiota composition, taxonomic alterations and host interactions...
February 2018: Gastroenterology Report
https://www.readbyqxmd.com/read/29474889/human-gut-microbiota-and-gastrointestinal-cancer
#19
REVIEW
Changting Meng, Chunmei Bai, Thomas D Brown, Leroy E Hood, Qiang Tian
Human gut microbiota play an essential role in both healthy and diseased states of humans. In the past decade, the interactions between microorganisms and tumors have attracted much attention in the efforts to understand various features of the complex microbial communities, as well as the possible mechanisms through which the microbiota are involved in cancer prevention, carcinogenesis, and anti-cancer therapy. A large number of studies have indicated that microbial dysbiosis contributes to cancer susceptibility via multiple pathways...
February 2018: Genomics, Proteomics & Bioinformatics
https://www.readbyqxmd.com/read/29468141/impact-of-the-gut-microbiota-on-intestinal-immunity-mediated-by-tryptophan-metabolism
#20
REVIEW
Jing Gao, Kang Xu, Hongnan Liu, Gang Liu, Miaomiao Bai, Can Peng, Tiejun Li, Yulong Yin
The gut microbiota influences the health of the host, especially with regard to gut immune homeostasis and the intestinal immune response. In addition to serving as a nutrient enhancer, L-tryptophan (Trp) plays crucial roles in the balance between intestinal immune tolerance and gut microbiota maintenance. Recent discoveries have underscored that changes in the microbiota modulate the host immune system by modulating Trp metabolism. Moreover, Trp, endogenous Trp metabolites (kynurenines, serotonin, and melatonin), and bacterial Trp metabolites (indole, indolic acid, skatole, and tryptamine) have profound effects on gut microbial composition, microbial metabolism, the host's immune system, the host-microbiome interface, and host immune system-intestinal microbiota interactions...
2018: Frontiers in Cellular and Infection Microbiology
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