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JOURNAL ARTICLE
Marta Olszewska, Agnieszka Malcher, Tomasz Stokowy, Nijole Pollock, Andrea J Berman, Sylwia Budkiewicz, Marzena Kamieniczna, Hanna Jackowiak, Joanna Suszynska-Zajczyk, Piotr Jedrzejczak, Alexander N Yatsenko, Maciej Kurpisz
STUDY QUESTION: Is the Tcte1 mutation causative for male infertility? SUMMARY ANSWER: Our collected data underline the complex and devastating effect of the single-gene mutation on the testicular molecular network, leading to male reproductive failure. WHAT IS KNOWN ALREADY: Recent data have revealed mutations in genes related to axonemal dynein arms as causative for morphology and motility abnormalities in spermatozoa of infertile males, including dysplasia of fibrous sheath (DFS) and multiple morphological abnormalities in the sperm flagella (MMAF)...
2024: Human Reproduction Open
#22
JOURNAL ARTICLE
Joseph B Lin, Kathryn L Pepple, Christian Concepcion, Yulia Korshunova, Michael A Paley, Grace L Paley, Jennifer Laurent, Rajendra S Apte, Lynn M Hassman
PURPOSE: Uveitis is a heterogenous group of inflammatory eye disease for which current cytokine-targeted immune therapies are effective for only a subset of patients. We hypothesized that despite pathophysiologic nuances that differentiate individual disease states, all forms of eye inflammation might share common mechanisms for immune cell recruitment. Identifying these mechanisms is critical for developing novel, broadly acting therapeutic strategies. DESIGN: Experimental study...
2024: Ophthalmol Sci
#23
REVIEW
Dora Maric, Salvatore Ficarra, Luca Di Bartolo, Carlo Rossi, Zoi Asimakopoulou, Apostolos Vantarakis, Ana Carbonell-Baeza, David Jiménez-Pavón, Beatriz Gomes, Paula Tavares, Rebecca Baxter, Susanna Pusa, Petra Thaller, Sofia Papakonstantinou, Musa Kirkar, Francesca Glorioso, Marina Galioto, Ambra Gentile, Ewan Thomas, Antonino Bianco
BACKGROUND: Sleep disorders are often complained by cancer patients and can last years after the end of therapies, leading to different negative consequences. Non-pharmacological strategies such as exercise interventions may be considered to counteract this phenomenon. The literature supports the beneficial effects of aerobic training (AT), while evidence on resistance training (RT) is scarce. Accordingly, our systematic review aims to investigate the potential novel effect of RT on sleep outcomes in cancer survivors...
April 2024: Cancer Medicine
#24
JOURNAL ARTICLE
Beata Bień, Piotr K Krajewski, Jacek C Szepietowski
BACKGROUND: Acne is a chronic inflammatory disease predominantly affecting young people. This study was undertaken to assess the impact of acne in young adults on their major life-changing decisions (MLCD), paying attention to the relationships between major life-changing decisions profile (MLCDP) and Quality of Life (QoL), feeling of stigmatization and acceptance of the disease. METHODS: The study was performed on 213 young people diagnosed with acne. A variety of questionnaires were employed to measure the clinical and psychological aspects of acne...
April 2024: Italian journal of dermatology and venereology
#25
JOURNAL ARTICLE
Danielle K Emmet, Glenn Davis, Stacey Pierce-Talsma, Jay H Shubrook, Wolf Mehling
CONTEXT: Interoceptive bodily awareness (IBA) is one's attentional focus on and relationship with comfortable and uncomfortable (e.g., pain) internal body sensations. Integrating IBA into research on osteopathic manipulative treatment (OMT) is growing, both as an outcome and predictor of treatment outcomes; however, it has yet to be studied in a clinical setting. OBJECTIVES: We aimed to conduct a pilot study to measure IBA, with the Multidimensional Assessment of Interoceptive Awareness (MAIA), in patients seeking OMT for pain, and to test if OMT exposure may be associated with higher IBA as measured by the MAIA...
April 24, 2024: Journal of osteopathic medicine
#26
JOURNAL ARTICLE
Di Zheng, Zhun Wei, Chong Zhang, Wenda Liu, Changtian Gong, Fei Wu, Weichun Guo
BACKGROUND: Osteosarcoma is a diverse and aggressive bone tumor. Driver genes regulating osteosarcoma initiation and progression remains incompletely defined. Zinc finger protein 692 (ZNF692), a kind of Krüppel C2H2 zinc finger transcription factor, exhibited abnormal expression in different types of malignancies and showed a correlation with the clinical prognosis of patients as well as the aggressive characteristics of cancer cells. Nevertheless, its specific role in osteosarcoma is still not well understood...
April 22, 2024: Biology Direct
#27
JOURNAL ARTICLE
Soo-Young Yoon, Jin Sug Kim, Su Woong Jung, Yang Gyun Kim, Ju-Young Moon, Sang-Ho Lee, Sung-Vin Yim, Hyeon Seok Hwang, Kyunghwan Jeong
BACKGROUND: IgA nephropathy (IgAN) is the most common type of primary glomerulonephritis, although the definitive markers are unknown. We aimed to investigate the clinical significance of urinary cytokines in patients with IgAN. METHODS: From 2009 to 2018, the patients were divided into three groups: IgAN (n = 191), disease control (n = 53), and normal control (n = 76). We used a multiplex enzyme-linked immunosorbent assay to measure 16 selected urinary inflammatory cytokines, evaluated the correlation between clinical and pathological features following regression analysis on progression...
April 22, 2024: BMC Nephrology
#28
JOURNAL ARTICLE
Patricia L Valda Toro, Andrew Willmore, Nelson E Wu, Kevin L Delucchi, Alejandra Jauregui, Pratik Sinha, Kathleen D Liu, Carolyn M Hendrickson, Aartik Sarma, Lucile P A Neyton, Aleksandra Leligdowicz, Charles R Langelier, Hanjing Zhuo, Chayse Jones, Kirsten N Kangelaris, Antonio D Gomez, Michael A Matthay, Carolyn S Calfee
BACKGROUND: Rapidly improving acute respiratory distress syndrome (RIARDS) is an increasingly appreciated subgroup of ARDS in which hypoxemia improves within 24 h after initiation of mechanical ventilation. Detailed clinical and biological features of RIARDS have not been clearly defined, and it is unknown whether RIARDS is associated with the hypoinflammatory or hyperinflammatory phenotype of ARDS. The purpose of this study was to define the clinical and biological features of RIARDS and its association with inflammatory subphenotypes...
April 22, 2024: Critical Care: the Official Journal of the Critical Care Forum
#29
JOURNAL ARTICLE
Tayyaba Gul Malik, Usman Mahboob, Rehan Ahmed Khan, Rabail Alam
BACKGROUND: History taking and clinical reasoning are important skills that require knowledge, cognition and meta-cognition. It is important that a trainee must experience multiple encounters with different patients to practice these skills. However, patient safety is also important, and trainees are not allowed to handle critically ill patients. To address this issue, a randomized controlled trial was conducted to determine the effectiveness of using Virtual Patients (VP) versus Standardized Patients (SP) in acquiring clinical reasoning skills in ophthalmology postgraduate residents...
April 22, 2024: BMC Medical Education
#30
JOURNAL ARTICLE
Kristi Elisabeth Heiberg, Monica Beckmann, Vigdis Bruun-Olsen
BACKGROUND: Older people with hip fracture are often medically frail, and many do not regain their walking ability and level of physical activity. The aim of this study was to examine the relationship between pre-fracture recalled mobility, fear of falling, physical activity, walking habits and walking speed one year after hip fracture. METHODS: The study had a longitudinal design. Measurements were performed 3-5 days postoperatively (baseline) and at one year after the hip fracture...
April 22, 2024: BMC Geriatrics
#31
JOURNAL ARTICLE
Ehsan Kakavandi, Kaveh Sadeghi, Mohammad Shayestehpour, Hossein Mirhendi, Abbas Rahimi Foroushani, Talat Mokhtari-Azad, Nazanin Zahra Shafiei Jandaghi, Jila Yavarian
BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly contagious virus that uses angiotensin converting enzyme 2 (ACE2), a pivotal member of the renin-angiotensin system (RAS), as its cell-entry receptor. Another member of the RAS, angiotensin II (Ang II), is the major biologically active component in this system. There is growing evidence suggesting that serum miRNAs could serve as prognostic biomarkers for SARS-CoV-2 infection and regulate ACE2 expression...
April 22, 2024: BMC Infectious Diseases
#32
JOURNAL ARTICLE
Jonathan Z Pan, Zhanqiang Wang, Wei Sun, Peipei Pan, Wei Li, Yongtao Sun, Shoulin Chen, Amity Lin, Wulin Tan, Liangliang He, Jacob Greene, Virginia Yao, Lijun An, Rich Liang, Qifeng Li, Jessica Yu, Lingyi Zhang, Nikolaos Kyritsis, Xuan Duong Fernandez, Sara Moncivais, Esmeralda Mendoza, Pamela Fung, Gongming Wang, Xinhuan Niu, Qihang Du, Zhaoyang Xiao, Yuwen Chang, Peiyuan Lv, J Russell Huie, Abel Torres-Espin, Adam R Ferguson, Debra D Hemmerle, Jason F Talbott, Philip R Weinstein, Lisa U Pascual, Vineeta Singh, Anthony M DiGiorgio, Rajiv Saigal, William D Whetstone, Geoffrey T Manley, Sanjay S Dhall, Jacqueline C Bresnahan, Mervyn Maze, Xiangning Jiang, Neel S Singhal, Michael S Beattie, Hua Su, Zhonghui Guan
BACKGROUND: Although many molecules have been investigated as biomarkers for spinal cord injury (SCI) or ischemic stroke, none of them are specifically induced in central nervous system (CNS) neurons following injuries with low baseline expression. However, neuronal injury constitutes a major pathology associated with SCI or stroke and strongly correlates with neurological outcomes. Biomarkers characterized by low baseline expression and specific induction in neurons post-injury are likely to better correlate with injury severity and recovery, demonstrating higher sensitivity and specificity for CNS injuries compared to non-neuronal markers or pan-neuronal markers with constitutive expressions...
April 2024: Clinical and Translational Medicine
#33
JOURNAL ARTICLE
Diego Angeles-Valdez, Jalil Rasgado-Toledo, Viviana Villicaña, Alan Davalos-Guzman, Cristina Almanza, Alfonso Fajardo-Valdez, Ruth Alcala-Lozano, Eduardo A Garza-Villarreal
Cocaine use disorder (CUD) is a global health problem with severe consequences, leading to behavioral, cognitive, and neurobiological disturbances. While consensus on treatments is still ongoing, repetitive transcranial magnetic stimulation (rTMS) has emerged as a promising approach for medication-resistant disorders, including substance use disorders. In this context, here we present the SUDMEX-TMS, a Mexican dataset from an rTMS clinical trial involving CUD patients. This longitudinal dataset comprises 54 CUD patients (including 8 females) with data collected at five time points: baseline (T0), two weeks (T1), three months (T2), six months (T3) follow-up, and twelve months (T4) follow-up...
April 22, 2024: Scientific Data
#34
JOURNAL ARTICLE
Mahanoor Baig, Nagesh C Nanjappa, Griffith B Perkins, Rachel Di Lernia, Venkatesan Thiruvenkatarajan, Pravin Hissaria
In Australia, neuromuscular blocking agents are the leading cause of perioperative anaphylaxis. Current investigation of suspected anaphylaxis includes tryptase levels, serum immunoglobulin E (IgE) levels, and skin testing, including intradermal testing and skin prick testing. The gold standard for the diagnosis of a hypersensitivity reaction is a challenge test, but this poses a risk to patient safety. An alternative test, known as the basophil activation test (BAT) is a form of cellular in vitro testing using flow cytometry to measure the degree of basophil degranulation within a sample of blood following exposure to an allergen...
April 22, 2024: Anaesthesia and Intensive Care
#35
JOURNAL ARTICLE
Bernhard Michalowsky, Lidia Engel, Maresa Buchholz, Niklas Weber, Thomas Kohlmann, Feng Xie
OBJECTIVES: To quantify health fluctuations, identify affected health-related quality of life (HRQoL) dimensions, and evaluate if fluctuations affect the HRQoL instruments recall period adherence in people living with dementia (PlwD). METHODS: Caregivers of PlwD completed a daily diary for 14 days, documenting if PlwD's health was better or worse than the day before and the affected HRQoL dimensions. Health fluctuation was categorized into low (0-4 fluctuations in 14 days), moderate (5-8) and high (9-14)...
April 20, 2024: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
#36
JOURNAL ARTICLE
Mohammad Darwish, Neil R Bergman, Richard J Hiscock
INTRODUCTION: Total hip arthroplasty implant choice profoundly affects survivorship, complications, and failure modes. This study evaluates the long-term (average 18 year) outcomes of ceramic-on-ceramic hip arthroplasty using uncemented shells and stems. Despite an impressive 20-year cumulative percent revision (CPR) of 5.9%, the hydroxyapatite proximally coated femoral components evaluated in this study have seen declining use since 2003. METHODS: A review of 349 consecutive total hip arthroplasties from 1999 to 2007 were matched to 272 cases with registry data...
April 20, 2024: Journal of Arthroplasty
#37
JOURNAL ARTICLE
Kendrick Campbell, Joel Vetter, Fernandino L Vilson, Shellee Ogawa, Wesley Baas, Aleksandra Klim, Alethea Paradis, Deborah Ksiazek, Diana Wolff, Henry Lai, Gregory Murphy
OBJECTIVE: To determine better in-office measures for artificial urethral sphincter outcomes, we investigated the ability of preoperative timed peg-transfer, pinch strength, grip strength, and Disabilities of the Arm Shoulder and Hand Outcome questionnaire in predicting postoperative satisfaction, confidence, and ease of use of artificial urethral sphincter placement for stress urinary incontinence. MATERIALS AND METHODS: A timed 9-hole peg test, pinch and grip strength assessment, and upper extremity questionnaire were administered during the preoperative visit before sphincter placement...
April 20, 2024: Urology
#38
Margarita Giraldo-Tugores, Cristina Camarero, Garbiñe Roy, Ana De Andrés, Moisés David Espejo-Mambié, Soledad Terrados-Cepeda, Belén de la Hoz
INTRODUCTION: The association between food protein-induced enterocolitis syndrome (FPIES) and wheat ingestion in children with celiac disease is unknown at this time. METHODS: We present seven cases of children with celiac disease who presented with symptoms of wheat-triggered acute FPIES (a-FPIES). An oral food challenge (OFC) with wheat allergen followed by 4 h of observation was performed. Activation of innate system cells was measured at baseline (T0), during symptoms (Ts), and 4 h after symptom onset (Ts + 4)...
April 22, 2024: International Archives of Allergy and Immunology
#39
JOURNAL ARTICLE
Paula Elizabeth Keating, Barry D Hock, Paul K L Chin, John Liston O'Donnell, Murray Lindsay Barclay
BACKGROUND: Detecting antidrug antibodies (ADAs) against infliximab or adalimumab is useful for therapeutic drug monitoring. Various ADA detection methods exist, and antibody titer is an output in some algorithms. Homogenous mobility shift assay (HMSA) measures relative ADA concentration and determines drug-ADA complex size in vitro. However, the relevance of complex size determination in drug monitoring remains unclear. Hence, the association between complex size, ADA concentration, and sample detectable neutralizing activity was evaluated...
April 9, 2024: Therapeutic Drug Monitoring
#40
JOURNAL ARTICLE
Alessandro Invernizzi, Chiara Zaffalon, Priscilla Manni, Federico Zicarelli, Domenico Chisari, Chantal Adani, Valentina Mastrofilippo, Elena Bolletta, Fabrizio Gozzi, Luca De Simone, Giovanni Staurenghi, Luca Cimino
PURPOSE: To assess inflammatory changes in the anterior vitreous (AV) using a swept source anterior segment optical coherence tomography (SS-ASOCT) and to correlate them with uveitis features and clinical grading of intraocular inflammation. METHODS: 140 eyes from 96 patients were included in this observational, cross-sectional study: 40 ACTIVE uveitis, 40 INACTIVE uveitis and 60 CONTROLS. All eyes underwent intraocular inflammation clinical grading (anterior chamber (AC) cells counting and vitreous haze evaluation) and AV imaging with SS-ASOCT...
April 22, 2024: Ocular Immunology and Inflammation
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