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https://www.readbyqxmd.com/read/29240964/psycho-emotional-disorders-as-incoming-risk-factors-for-myocardial-infarction-with-non-obstructive-coronary-arteries
#1
Javier López-Pais, Bárbara Izquierdo Coronel, David Galán Gil, María Jesús Espinosa Pascual, Carlos Gustavo Martinez Peredo, Paula Awamleh García, Juan Górriz Magaña, Rebeca Mata Caballero, Alfonso Fraile Sanz, Javier Muñiz, Joaquín J Alonso Martín
BACKGROUND: There is an emerging field underlying the myocardial infarction with non-obstructive coronary arteries (MINOCA). The aim of this study was to evaluate the impact of psycho-emotional disorders and social habits in MINOCA patients. METHODS: The study included 95 consecutive patients diagnosed of MINOCA and 178 patients with myocardial infarction (MI) and obstructive lesions. MINOCA patients were included when they fulfilled the three main criteria: Accomplishment of the Third Universal Definition of Myocardial Infarction, absence of obstructive coronary arteries and no clinically overt specific cause for the acute presentation...
December 14, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/29240961/anomalous-origin-of-culprit-coronary-arteries-in-acute-coronary-syndromes
#2
Paweł Tyczyński, Krzysztof Kukuła, Arkadiusz Pietrasik, Tomasz Bochenek, Artur Dębski, Anna Oleksiak, Miłosz Marona, Michał Lelek, Janina Stępińska, Adam Witkowski
BACKGROUND: To describe a series of acute coronary syndrome (ACS) patients in whom anomalous origin of culprit coronary artery (AOCCA) was diagnosed. Percutaneous coronary interventions (PCI) in AOCCA are performed very infrequently. METHODS: Electronic databases from three high-volume tertiary cardiac centers were retrospectively searched for the presence of AOCCA in ACS. RESULTS: Different types of AOCCA in ACS were identified in 20 patients...
December 14, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/29240651/acute-impact-of-different-exercise-modalities-on-arterial-and-platelet-function
#3
Andrew Haynes, Matthew D Linden, Elisa Robey, Gerald F Watts, P Hugh R Barrett, Louise H Naylor, Daniel J Green
PURPOSE: Acute coronary syndromes and ischemic stroke are associated with arterial events involving platelets, the endothelium and atherosclerosis. Whilst regular physical activity is associated with lower risk of cardiovascular events and mortality, risk is transiently increased during and immediately following participation in an acute bout of exercise. No previous study has investigated the acute impact of exercise on platelet activation and arterial function in the same participants; it is also unknown if responses are dependent on exercise modality...
December 13, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29239935/the-impact-of-primary-antiphospholipid-syndrome-on-long-term-cardiovascular-outcomes-after-percutaneous-coronary-intervention-and-stenting-in-patients-with-myocardial-infarction
#4
Mauricio Mora-Ramirez, Héctor Gonzalez-Pacheco, Luis M Amezcua-Guerra
Little is known about the incidence of major adverse cardiovascular events (MACEs) in patients with primary antiphospholipid syndrome (PAPS) undergoing percutaneous coronary intervention (PCI) and stenting due to myocardial infarction (MI).We performed a case-control study, nested in a cohort of 7238 patients with MI. Only 5 PAPS patients who underwent PCI and stenting were found, and they were compared with 15 non-antiphospholipid syndrome (APS) patients. A history of MI and stroke was noticeable in PAPS patients despite a lower frequency of traditional cardiovascular risk factors than in control subjects...
December 12, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29239886/acute-coronary-artery-dissection-a-review-of-the-literature-and-current-evidence
#5
Syed Raza Shah, Richard Alweis
Acute coronary artery dissection is a rare, complex disease occurring particularly in young women without traditional cardiovascular risk factors. The pathophysiology and treatment are different from acute coronary syndrome caused by plaque rupture or erosion. Its clinical presentation may vary from unstable angina to sudden cardiac death. Hence, early detection is crucial to manage the dissection and reduce the mortality and morbidity rates. Most coronary dissections will heal spontaneously, and conservative treatment is recommended for uncomplicated cases...
December 12, 2017: Cardiology in Review
https://www.readbyqxmd.com/read/29239257/cardiac-magnetic-resonance-assessment-of-diastolic-dysfunction-in-acute-coronary-syndrome
#6
Shah M Azarisman, Karen S Teo, Matthew I Worthley, Stephen G Worthley
Chest pain is an important presenting symptom. However, few cases of chest pain are diagnosed as acute coronary syndrome (ACS) in the acute setting. This results in frequent inappropriate discharge and major delay in treatment for patients with underlying ACS. The conventional methods of assessing ACS, which include electrocardiography and serological markers of infarct, can take time to manifest. Recent studies have investigated more sensitive and specific imaging modalities that can be used. Diastolic dysfunction occurs early following coronary artery occlusion and its detection is useful in confirming the diagnosis, risk stratification, and prognosis post-ACS...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/29239221/high-density-lipoprotein-and-cardiac-glucose-metabolism-implications-for-management-of-acute-coronary-syndromes
#7
Adele L Richart, Sarah E Heywood, Andrew L Siebel, Bronwyn A Kingwell
No abstract text is available yet for this article.
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29238804/efficacy-of-high-sensitivity-troponin-t-in-identifying-very-low-risk-patients-with-possible-acute-coronary-syndrome
#8
W Frank Peacock, Brigette M Baumann, Deborah Bruton, Thomas E Davis, Beverly Handy, Christopher W Jones, Judd E Hollander, Alexander T Limkakeng, Abhi Mehrotra, Martin Than, Andre Ziegler, Carina Dinkel
Importance: Physicians need information on how to use the first available high-sensitivity troponin (hsTnT) assay in the United States to identify patients at very low risk for 30-day adverse cardiac events (ACE). Objective: To determine whether a negative hsTnT assay at 0 and 3 hours following emergency department presentation could identify patients at less than 1% risk of a 30-day ACE. Design, Setting, and Participants: A prospective, observational study at 15 emergency departments in the United States between 2011 and 2015 that included individuals 21 years and older, presenting to the emergency department with suspected acute coronary syndrome...
December 13, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/29237744/change-in-cognitive-function-in-the-month-after-hospitalization-for-acute-coronary-syndromes-findings-from-trace-core-transition-risks-and-actions-in-coronary-events-center-for-outcomes-research-and-education
#9
Jane S Saczynski, David D McManus, Molly E Waring, Darleen Lessard, Milena D Anatchkova, Jerry H Gurwitz, Jeroan Allison, Arlene S Ash, Richard H McManus, David C Parish, Robert J Goldberg, Catarina I Kiefe
BACKGROUND: Cognitive function is often impaired during hospitalization, but whether this impairment resolves or persists after discharge is unknown. METHODS AND RESULTS: We enrolled (April 2011-May 2013) and interviewed during hospitalization and 1-month post-discharge 1521 nondemented acute coronary syndrome survivors enrolled in TRACE (Transitions, Risks and Actions in Coronary Events). Cognitive function was assessed using the Telephone Interview of Cognitive Status (range: 0-41) at both time points...
December 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/29236988/diagnostic-and-prognostic-value-of-myocardial-blood-flow-quantification-as-non-invasive-indicator-of-cardiac-allograft-vasculopathy
#10
Paco E Bravo, Brian A Bergmark, Tomas Vita, Viviany R Taqueti, Ankur Gupta, Sara Seidelmann, Thomas E Christensen, Michael T Osborne, Nishant R Shah, Nina Ghosh, Jon Hainer, Courtney F Bibbo, Meagan Harrington, Fred Costantino, Mandeep R Mehra, Sharmila Dorbala, Ron Blankstein, Akshay Desai, Lynne Stevenson, Michael M Givertz, Marcelo F Di Carli
Aims: Cardiac allograft vasculopathy (CAV) is a leading cause of death in orthotopic heart transplant (OHT) survivors. Effective non-invasive screening methods are needed. Our aim was to investigate the added diagnostic and prognostic value of myocardial blood flow (MBF) to standard myocardial perfusion imaging (MPI) with positron emission tomography (PET) for CAV detection. Methods and results: We studied 94 OHT recipients (prognostic cohort), including 66 who underwent invasive coronary angiography and PET within 1 year (diagnostic cohort)...
December 8, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29236323/effects-of-microrna-330-on-vulnerable-atherosclerotic-plaques-formation-and-vascular-endothelial-cell-proliferation-through-the-wnt-signaling-pathway-in-acute-coronary-syndrome
#11
Jing Ren, Rui Ma, Zhu-Bo Zhang, Yang Li, Ping Lei, Jian-Long Men
This study is designed to investigate the effects of microRNA (miR)-330 on atherosclerotic plaques formation and vascular endothelial (VE) cell proliferation by targeting MAPK8 through the WNT signaling pathway in rats with acute coronary syndrome (ACS). Expression of hemodynamic variables were tested. Rats were allocated into control, blank, negative control (NC), miR-330 mimic, miR-330 inhibitor, DDK-1, miR-330 inhibitor + DDK-1 groups. ELISA was used to evaluate the expression of TC, TG, LDL-C, hs-CRP, IL-6, IL-10, TNF-α, and SAA...
December 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29236216/long-term-outcomes-of-a%C3%A2-caucasian-cohort-presenting-with-acute-coronary-syndrome-and-or-out-of-hospital-cardiac-arrest-caused-by-coronary-spasm
#12
W Vlastra, M Piek, M A van Lavieren, M E J C Hassell, B E Claessen, G W Wijntjens, T P van de Hoef, K D Sjauw, M A Beijk, R Delewi, J J Piek
BACKGROUND: Coronary artery spasm may be the underlying mechanism in up to 10% of cases of acute coronary syndrome (ACS) and sudden cardiac death. Asian individuals exhibit a 3-times greater incidence of spasm than Caucasians; this is likely due to different types of mechanisms. Consequently, solid data is limited about the long-term prognosis in Caucasian patients presenting with ACS and/or out-of-hospital cardiac arrest (OHCA) caused by coronary spasm. METHODS: Between 2002 and 2015, thirty Caucasian patients with coronary artery spasm presenting with ACS (N = 29) and/or OHCA (N = 11) were enrolled in this prospective registry...
December 13, 2017: Netherlands Heart Journal
https://www.readbyqxmd.com/read/29236148/dual-antiplatelet-therapy-after-percutaneous-coronary-intervention-for-stable-cad-or-acs-redefining-the-optimal-duration-of%C3%A2-treatment
#13
B E Stähli, U Landmesser
The duration and combination of dual antiplatelet therapy after coronary stent implantation, consisting of aspirin and a P2Y12 inhibitor, is among the most intensely investigated therapeutic strategies in cardiovascular medicine. While initial studies have mainly focused on the efficacy and safety of individual antithrombotic agents, the increased need for a personalized, risk-based approach to define the optimal duration of antithrombotic treatment according to the estimated ischemic and bleeding risk was then recognized...
December 13, 2017: Herz
https://www.readbyqxmd.com/read/29236147/-platelet-inhibition-in-elderly-patients
#14
A Schäfer, J Bauersachs
Single antiplatelet therapy (SAPT) using predominantly acetylsalicylic acid (ASA) is the baseline anti-thrombotic therapy in primary as well as secondary prevention of atherosclerotic disease. Dual antiplatelet therapy (DAPT) is the cornerstone of maintenance medication following elective percutaneous coronary interventions or acute coronary syndromes (ST elevation myocardial infarction, non-ST elevation myocardial infarction and unstable angina pectoris). In the past the duration of DAPT in particular has been frequently discussed...
December 13, 2017: Herz
https://www.readbyqxmd.com/read/29234694/contemporary-data-on-treatment-practices-for-low-density-lipoprotein-cholesterol-in-3867-patients-who-had-suffered-an-acute-coronary-syndrome-across-the-world
#15
Anselm K Gitt, Dominik Lautsch, Jean Ferrières, Gaetano M De Ferrari, Ami Vyas, Carl A Baxter, Lori D Bash, Veronica Ashton, Martin Horack, Wael Almahmeed, Fu-Tien Chiang, Kian Keong Poh, Philippe Brudi, Baishali Ambegaonkar
DYSIS II ACS was a longitudinal, observational study in 3867 patients from 18 countries. They were being hospitalized after suffering an acute coronary syndrome. Evaluations were performed at the time of admission and again 120±15 days following the date of admission (the follow-up time point). 2521 patients were on active lipid lowering treatment (LLT) at admission. Mean atorvastatin dose was 22 mg per day and 2.7% received ezetimibe in combination with a statin. At discharge from hospital, 3767 patients received LLT expressed as a mean atorvastatin dose of 36 mg per day with 4...
February 2018: Data in Brief
https://www.readbyqxmd.com/read/29233491/utility-of-myeloperoxidase-in-the-differential-diagnosis-of-acute-coronary-syndrome
#16
Pilar Calmarza, Carlos Lapresta, María Martínez, Raquel Lahoz, Javier Povar
OBJECTIVES: To determine the usefulness of myeloperoxidase in discriminating between patients with acute coronary syndrome and patients with chest pain by other causes. METHODS: The study included all patients over 18 years of age who come consecutively to the emergency department from September 2015 to December 2015 with chest pain of non-traumatic origin. The initial patient evaluation was performed according to the study protocol for patients with suspected acute coronary syndrome (ACS) in our Emergency Department...
December 7, 2017: Archivos de Cardiología de México
https://www.readbyqxmd.com/read/29233189/head-to-head-comparison-of-prasugrel-versus-ticagrelor-in-patients-with-acute-coronary-syndrome-a-systematic-review-and-meta-analysis-of-randomized-trials
#17
Pravesh Kumar Bundhun, Jia-Xin Shi, Feng Huang
BACKGROUND: Prasugrel and Ticagrelor are emerging antiplatelet drugs that might have the potential to replace currently used antiplatelet agents. Previous analyses comparing prasugrel with ticagrelor mainly focused on an indirect comparison whereas direct comparison was reported only in a few recently published trials. We aimed to systematically carry out a head to head comparison of the adverse clinical outcomes which were associated with prasugrel versus ticagrelor in patients with acute coronary syndrome (ACS)...
December 12, 2017: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29232563/immunologic-burden-links-periodontitis-to-acute-coronary-syndrome
#18
John M Liljestrand, Susanna Paju, Milla Pietiäinen, Kåre Buhlin, G Rutger Persson, Markku S Nieminen, Juha Sinisalo, Päivi Mäntylä, Pirkko J Pussinen
BACKGROUND AND AIMS: Periodontitis, a common polymicrobial inflammatory disease in the tooth supporting tissues, is a risk factor for coronary artery disease. One of the proposed underlying mechanisms is the systemic immune response to periodontal infection. We studied how serum antibodies against seven periodontal pathogens and their subgingival levels associate with each other, periodontitis, and coronary artery disease. METHODS: The Parogene cohort included 505 Finnish patients (mean age 63 y) who underwent coronary angiography, and clinical and radiographic oral examinations...
December 6, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29230658/guidelines-in-review-comparison-of-the-2014-aha-acc-guideline-for-the-management-of-patients-with-non-st-elevation-acute-coronary-syndromes-and-the-2015-esc-guidelines-for-the-management-of-acute-coronary-syndromes-in-patients-presenting-without-persistent
#19
Shane P Prejean, Munaib Din, Eliana Reyes, Fadi G Hage
In this Guidelines in Review, we review side-by-side the recommendations provided by the 2014 AHA/ACC Guideline for the management of patients with non-ST-elevation acute coronary syndromes and the 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. We review the recommendations for imaging in the evaluation of patients with possible ACS followed by the diagnostic evaluation of patients with proven NSTE-ACS, based on their risk for adverse clinical events...
December 11, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29230421/association-of-vitamin-d-deficiency-and-degree-of-coronary-artery-disease-in-cardiac-patients-with-type-2-diabetes
#20
Ewelina A Dziedzic, Jakub S Gąsior, Mariusz Pawłowski, Marek Dąbrowski
Several modifiable factors may influence cardiac function in diabetic patients. The aim of the study was to evaluate the influence of vitamin D level on the stage of coronary atherosclerosis in cardiac patients diagnosed with type 2 diabetes. The study was performed in 337 consecutive patients undergoing coronarography. The stage of atherosclerosis was evaluated using Coronary Artery Surgery Study Score. The plasma 25(OH)D concentration was determined by an electrochemiluminescence method. Patients without significant lesions in coronary arteries presented the highest 25(OH)D level, significantly higher than patients with one-, two-, and three-vessel coronary artery disease (CAD) (p < 0...
2017: Journal of Diabetes Research
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