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Total Lung Denevation

Stoycho D Stoev, Dimitrina Gundasheva, Ivan Zarkov, Teodora Mircheva, Dimitrina Zapryanova, Stefan Denev, Yuri Mitev, Hristo Daskalov, Mike Dutton, Mulunda Mwanza, Yves-Jacques Schneider
Mycotoxic nephropathy was induced in eighteen young pigs by mouldy diets containing 0.5 ppm ochratoxin A (OTA) and/or 10 ppm fumonisin B1 (FB1) for three months. While the most obvious damages provoked by OTA were seen in the kidneys as expressed by the strong degenerative changes in proximal tubules and fibrosis in kidneys, FB1 was found to induce an increase in permeability of vessels mainly in lung, brain, cerebellum or kidneys and slight to moderate degenerative changes in kidneys. Pathomorphological damages in pigs exposed to both mycotoxins simultaneously present a combination of the main lesions provoked by each mycotoxin alone being stronger in their expression...
November 2012: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
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