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https://www.readbyqxmd.com/read/29458210/preparation-of-a-solid-self-microemulsifying-drug-delivery-system-by-hot-melt-extrusion
#1
Luis Antonio D Silva, Susana L Almeida, Ellen C P Alonso, Priscila B R Rocha, Felipe T Martins, Luís A P Freitas, Stephania F Taveira, Marcilio S S Cunha-Filho, Ricardo N Marreto
Hot-melt extrusion (HME) has gained increasing attention in the pharmaceutical industry; however, its potential in the preparation of solid self-emulsifying drug delivery systems (S-SMEDDS) is still unexplored. This study sought to prepare enteric S-SMEDDS by HME and evaluate the effects of the process and formulation variables on S-SMEDDS properties via Box-Behnken design. Liquid SMEDDS were developed, and carvedilol was used as a class II model drug. Mean size, polydispersity index (PdI) and zeta potential of the resulting microemulsions were determined...
February 16, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29458106/combi-metal-organic-framework-combi-mof-of-%C3%AE-amylase-and-glucoamylase-for-one-pot-starch-hydrolysis
#2
Manish Salgaonkar, Shamraja S Nadar, Virendra K Rathod
The multi-enzyme biocatalyst allows to run in vitro multi-step cascade reactions in a single pot. An efficient combi-metal organic frameworks (combi-MOF) of α-amylase and glucoamylase for one pot starch hydrolysis was constructed by mixing zinc acetate and 2‑methylimmidazole with enzyme mixture in one pot under biocompatible conditions. The prepared combi-MOF was characterized and analyzed by powder X-ray diffraction (PXRD), Fourier transform infrared (FT-IR), thermogravimetric analysis (TGA) and scanning electron microscopy (SEM)...
February 16, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29458103/zinc-oxide-nanorod-clusters-deposited-seaweed-cellulose-sheet-for-antimicrobial-activity
#3
Priyank L Bhutiya, Mayur S Mahajan, M Abdul Rasheed, Manoj Pandey, S Zaheer Hasan, Nirendra Misra
Seaweed cellulose was isolated from green seaweed Ulva fasciata using a common bleaching agent. Sheet containing porous mesh was prepared from the extracted seaweed crystalline cellulose along with zinc oxide (ZnO) nanorod clusters grown over the sheet by single step hydrothermal method. Seaweed cellulose and zinc oxide nanorod clusters deposited seaweed cellulose sheet was characterized by FT-IR, XRD, TGA, and SEM-EDX. Morphology showed that the diameter of zinc oxide nanorods were around 70 nm. Zinc oxide nanorod clusters deposited on seaweed cellulose sheet gave remarkable antibacterial activity towards gram-positive (Staphylococcus aureus, Bacillus ceresus, Streptococcus thermophilis) and gram-negative (Escherichia coli, Pseudomonas aeruginous) microbes...
February 16, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29458016/renal-toxicological-evaluations-of-sulphonated-nanocellulose-from-khaya-sengalensis-seed-in-wistar-rats
#4
Adewale Adewuyi, Chiagoziem A Otuechere, Olusegun L Adebayo, Chibuzo Anazodo, Fabiano V Pereira
Nanocellulose is currently gaining attention due to its unique properties. This attention includes its application as building blocks for developing novel functional materials, plant drug and also in drug delivery systems. However, its safety remains largely untested or less understood. Thus, sulphonated nanocellulose (KSS) was prepared from cellulose (KSC) isolated from Khaya senegalensis seed (KS). KS, KSC and KSS were characterized using Fourier transformed infrared (FTIR), X-ray diffraction (XRD), thermogravimetric analysis (TG), particle size distribution (PSD), zeta potential and scanning electron microscopy (SEM)...
February 16, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29457925/controlled-release-of-mitomycin-c-from-phemah-cu-ii-cryogel-membranes
#5
Monireh Bakhshpour, Handan Yavuz, Adil Denizli
Molecular imprinting technique was used for the preparation of antibiotic and anti-neoplastic chemotherapy drug (mitomycin C) imprinted cryogel membranes (MMC-ICM). The membranes were synthezied by using metal ion coordination interactions with N-methacryloyl-(l)-histidine methyl ester (MAH) functional monomer and template molecules (i.e. MMC). The 2-hydroxyethyl methacrylate (HEMA) monomer and methylene bisacrylamide (MBAAm) crosslinker were used for the preparation of mitomycin C imprinted cryogel membranes by radical suspension polymerization technique...
February 19, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29457824/understanding-the-conformational-analysis-of-gababutin-based-hybrid-peptides
#6
Maruthi Konda, Rohit G Jadhav, Sayan Maiti, Shaikh M Mobin, Brice Kauffmann, Apurba K Das
Constrained γ-amino acid gababutin (Gbn) based peptides that form different conformations have been synthesized. Striving to rationalize the impact of side chain orientations framing tetrapeptide-based supramolecular organic frameworks and morphological entities, Gbn incorporated hybrid peptides Boc-Gbn-Aib-Aaa-Aib-OMe (where Aaa = Phe(F) for peptide 1, Leu(L) for peptide 2 and Tyr(Y) for peptide 3) were synthesized by changing the amino acid at the third position. The solution state dual folded conformation (C12 /C10 H-bonded) is probed by 2D NMR spectroscopy in support of a DMSO-d6 titration and VT NMR experiments...
February 19, 2018: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29457668/the-relationships-between-depression-neuroticism-and-attitudes-nda-model-in-heroin-abusers-in-taiwan
#7
Kun-Hua Lee, Cheng-Fang Yen
BACKGROUND AND OBJECTIVES: Heroin use is a severe problem worldwide. To develop more effective treatments for heroin abusers, a comprehensive psychosocial model of heroin use should be established and examined. We created and assessed a neuroticism, depression, attitudes, and heroin addiction (NDA) model. METHODS: In this cross-sectional study, 234 patients undergoing methadone replacement treatment were recruited from psychiatric clinics. We used Structural Equation Modeling (SEM) to assess all for neuroticism, depression, and a positive outcome expectancy (POE) (attitudes)...
February 19, 2018: American Journal on Addictions
https://www.readbyqxmd.com/read/29457593/characterization-study-and-optimization-of-swelling-behavior-for-p-hema-co-eudragit-l-100-hydrogels-by-using-taguchi-method
#8
Hediye Irem Ozgunduz, Abdullah Bilal Ozturk, Hava Gizem Kandilci, Nil Acarali
The aim of this study is to produce the smart hydrogel to use insulin release for human body. p(HEMA-co-Eudragit L-100) hydrogels containing different ratios of 2-Hydroxyethyl methacrylate (HEMA) and Eudragait L-100 were synthesized by using ammonium persulfate (APS) as an initiator and ethylene glycol dimethacrylate (EGDMA) as a cross linker. The structures of hydrogels produced were characterized by using Fourier Transform Infrared Spectroscopy (FT-IR) and Scanning electron microscope (SEM) analysis. In this way, optimum synthesis conditions were determined for p(HEMA-co-Eudragit L-100) hydrogels by using Taguchi method as an optimization method...
2018: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/29457257/pharmacokinetics-pharmacodynamics-and-metabolism-of-acepromazine-following-intravenous-oral-and-sublingual-administration-to-exercised-thoroughbred-horses
#9
H K Knych, K Seminoff, D S McKemie, P H Kass
Acepromazine is a tranquilizer used commonly in equine medicine. This study describes serum and urine concentrations and the pharmacokinetics and pharmacodynamics of acepromazine following intravenous, oral, and sublingual (SL) administration. Fifteen exercised adult Thoroughbred horses received a single intravenous, oral, and SL dose of 0.09 mg/kg of acepromazine. Blood and urine samples were collected at time 0 and at various times for up to 72 hr and analyzed for acepromazine and its two major metabolites (2-(1-hydroxyethyl) promazine and 2-(1-hydroxyethyl) promazine sulfoxide) using liquid chromatography-tandem mass spectrometry...
February 18, 2018: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29457156/effect-of-calcium-hydroxide-on-bonding-performance-of-an-experimental-self-etch-adhesive
#10
Marcelle Gonçalves Garcia, Laiza Tatiana Poskus, Viviane Hass, Cristiane Mariote Amaral, Jaime Dutra Noronha-Filho, Eduardo Moreira da Silva
PURPOSE: To investigate the effect of Ca(OH)2 concentration on pH neutralization, degree of conversion (DC%), and bonding performance of experimental self-etch adhesives (SEAs). MATERIALS AND METHODS: Four different concentrations of Ca(OH)2 (0 wt%, 1 wt%, 2 wt%, and 4 wt%) were added to the bond of an experimental two-step SEA consisting of primer (10-MDP [30 wt%], TEG-DMA [30 wt%], ethanol [35 wt%], water [5 wt%], camphorquinone [0.5 wt%], and tertiary amine [0...
February 16, 2018: Journal of Adhesive Dentistry
https://www.readbyqxmd.com/read/29456729/expression-of-matrix-metalloproteinase-7-correlates-with-the-invasion-of-t1-colorectal-carcinoma
#11
Fumihiko Urushibara, Eisuke Shiozawa, Hideyuki Miyachi, Masashi Misawa, Tomonari Cho, Yusuke Takehara, Nana Arai, Toshitaka Funaki, Sakiko Tazawa, Mayumi Homma, Tomoko Norose, Mutsuko Omatsu, Toshiko Yamochi, Toshiaki Kunimura, Genshu Tate, Kazuho Honda, Ishida Fumio, Shin-Ei Kudo, Masafumi Takimoto
T1 colorectal carcinomas (CRCs) are an initial site of metastatic spread. Various risk factors for lymph node metastasis have been investigated in T1 CRCs. However, the major step in the entire process of metastasis remains unclear. In terms of carcinoma invasion and metastasis, matrix metalloproteinases (MMPs) have recently gained increasing attention. Notably, MMP-7 is frequently overexpressed in CRCs, but its implication has not been determined in T1 CRCs yet. The present study aimed to clarify the associations between the pathological risk factors of T1 CRCs and MMP-7...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29456011/effect-of-retention-rate-of-fluorescent-cellulose-nanofibrils-on-paper-properties-and-structure
#12
Qijun Ding, Jinsong Zeng, Bin Wang, Wenhua Gao, Kefu Chen, Zhe Yuan, Jun Xu, Darong Tang
In this work, we report a new characterization method using fluorescent cellulose nanofibrils to analyze retention and loss rates in the papermaking process. Cellulose nanofibrils (CNF) were isolated from chemical pulp by enzymatic pretreatment and used as a strengthening additive in sheet forming. The aim of this paper was to investigate its effects on flocculation, retention and loss rate and the physical and mechanical properties. CNF was subjected to fluorescent labeling with RBITC (Rhodamine B isothiocyanate), and the retention of fluorescent cellulose nanofibrils (FCNF) was analyzed by elemental analysis and fluorescence intensity...
April 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29456001/soluble-soybean-polysaccharide-tio-2-bionanocomposite-film-for-food-application
#13
Davoud Salarbashi, Mohsen Tafaghodi, Bibi Sedigheh Fazly Bazzaz
In the current study, a set of biodegradable soybean polysaccharide (SSPS) nanocomposites containing different ratios of TiO2 nanoparticles was characterized as new packaging system. X-ray diffraction (XRD) measurement showed that the crystalline structure of the TiO2 nanoparticles remained intact in the polysaccharide matrix and the surface of nanocomposites containing 1-3% TiO2 was observed morphologically uniform under scanning electron microscopy (SEM). Dynamic mechanical thermal analysis revealed that the magnitude of storage modulus was 3...
April 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29455999/cellulaose-acetate-based-thin-film-nanocomposite-reverse-osmosis-membrane-incorporated-with-tio-2-nanoparticles-for-improved-performance
#14
Muhammad Shafiq, Aneela Sabir, Atif Islam, Shahzad Maqsood Khan, Nafisa Gull, Syed Nadir Hussain, Muhammad Taqi Zahid Butt
In this work, cellulose acetate (CA) based thin film nanocomposite reverse osmosis (RO) membranes were fabricated using dissolution casting method by optimizing the CA/polyethylene glycol (CA/PEG-400) ratios for improved RO performance. The selectivity of optimized membrane was further enhanced by incorporating TiO2 (0-25 wt.%) nanoparticles. Fourier transform infrared spectroscopy (FTIR), thermogravimetric analyzer (TGA), scanning electron microscopy (SEM) and X-ray diffraction (XRD) were conducted to characterize control and modified membranes for the analysis of functional groups, thermal properties, morphology and structural investigation respectively...
April 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29455996/heterogeneous-in-situ-polymerization-of-polyaniline-pani-nanofibers-on-cotton-textiles-improved-electrical-conductivity-electrical-switching-and-tuning-properties
#15
Nadeeka D Tissera, Ruchira N Wijesena, Samantha Rathnayake, Rohini M de Silva, K M Nalin de Silva
Electrically conductive cotton fabric was fabricated by in situ one pot oxidative polymerization of aniline. Using a simple heterogeneous polymerization method, polyaniline (PANI) nano fibers with an average fiber diameter of 40-75 nm were grafted in situ onto cotton fabric. The electrical conductivity of the PANI nanofiber grafted fabric was improved 10 fold compared to fabric grafted with PANI nanoclusters having an average cluster size of 145-315 nm. The surface morphology of the cotton fibers was characterized using SEM and AFM...
April 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29455988/fabrication-of-novel-nanohybrids-by-impregnation-of-cuo-nanoparticles-into-bacterial-cellulose-and-chitosan-nanofibers-characterization-antimicrobial-and-release-properties
#16
Hadi Almasi, Paria Jafarzadeh, Laleh Mehryar
The efficiency of bacterial cellulose nanofibers (BCNF) and chitosan nanofibers (CHNF) were compared, aiming at fabricating novel organic-inorganic nanohybrids containing copper oxide (CuO) nanoparticles (NPs). FT-IR spectra confirmed the formation of real nanohybrids through occurring new interactions between CuO NPs and nanofibers. XRD results indicated that both the crystallite size and the crystallinity index of nanofibers decreased after nanohybrid formation. Noticeably, these morphological changes for CHNF were more than those for BCNF...
April 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29455973/microbicidal-gentamicin-alginate-hydrogels
#17
Stalin Kondaveeti, Pedro Vinicius de Assis Bueno, Ana Maria Carmona-Ribeiro, Fernanda Esposito, Nilton Lincopan, Maria Rita Sierakowski, Denise Freitas Siqueira Petri
Sodium alginate (Alg) reacted with antibiotic gentamicin sulfate (GS) in an aqueous-phase condition mediated by carbodiimide chemistry, in the molar ratios Alg: GS of (1:0.5), (1:1) and (1:2). The Alg-GS conjugated derivatives were characterized by elemental analysis for nitrogen content, Fourier transform infrared spectroscopy in the attenuated total reflection mode (FTIR-ATR), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), thermogravimetric analyses (TGA) and water sorption measurements...
April 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29455539/immunological-evaluation-of-chitosan-nanoparticles-loaded-with-tetanus-toxoid
#18
M Ghalavand, M Saadati, A Ahmadi, E Abbasi, J Salimian
OBJECTIVES: The present study was aimed at comparing tetanus toxoid (TT)‑loaded-chitosan nanoparticles with aluminum hydroxide as a common vaccine adjuvant. BACKGROUND: Tetanus remains to be a major public health problem. Nanoparticles have been extensively used as immune adjuvants. Tetanus toxoid (TT) encapsulated in chitosan nanoparticles is considered to be a promising tetanus vaccine candidate. METHODS: TT‑loaded chitosan nanoparticles were prepared by the ionic gelation method...
2018: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29455356/a-novel-electrocatalytic-approach-for-effective-degradation-of-rh-b-in-water-using-carbon-nanotubes-and-agarose
#19
Haiyang Liu, Miao Ren, Zhaocheng Zhang, Jiao Qu, Ying Ma, Nan Lu
Carbon nanotubes (CNTs)/agarose (AG) membrane on the ITO (indium tin oxide) conductive glass, with high efficiency of electrocatalytic degradation for rhodamine B (Rh-B) in water, was prepared using an easy and green method. The prepared CNTs/AG membrane was characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), energy dispersive spectra (EDS), infrared spectroscopy (IR), and electrochemical impedance spectroscopy (EIS). The results revealed that CNTs were dispersed in the AG membrane...
February 18, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29455355/the-combination-of-luffa-cylindrical-fibers-and-metal-oxides-offers-a-highly-performing-hybrid-fiber-material-in-water-decontamination
#20
Aida Kesraoui, Sarra Bouzaabia, Mongi Seffen
The present investigation aims to prepare a hybrid material from Luffa cylindrica and metal oxides (ZnO, Al2 O3 ) by precipitation for different percentages of zinc and aluminum (1, 2, and 4%) with a determined amount of biomass (a diameter of 250 μm). Physicochemical characterization of "Luffa cylindrica" and "Luffa cylindrica-metal oxides" was carried out by Boehm titration, pHPZC determination, scanning electron microscopy (SEM), and FTIR spectroscopic analysis. The process was optimized according to the adsorbed amount of methylene blue: MB (cationic dye) and methyl orange: MO (anionic dye) onto Luffa cylindrica and hybrid materials prepared...
February 18, 2018: Environmental Science and Pollution Research International
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