Steven Guan, Nick Tustison, Kun Qing, Yun Michael Shim, John Mugler, Talissa Altes, Dana Albon, Deborah Froh, Borna Mehrad, James Patrie, Alan Ropp, Braden Miller, Jill Nehrbas, Jaime Mata
3D Single-breath Chemical Shift Imaging (3D-SBCSI) is a hybrid MR-spectroscopic imaging modality that uses hyperpolarized xenon-129 gas (Xe-129) to differentiate lung diseases by probing functional characteristics. This study tests the efficacy of 3D-SBCSI in differentiating physiology among pulmonary diseases. A total of 45 subjects-16 healthy, 11 idiopathic pulmonary fibrosis (IPF), 13 cystic fibrosis (CF), and 5 chronic obstructive pulmonary disease (COPD)-were given 1/3 forced vital capacity (FVC) of hyperpolarized Xe-129, inhaled for a ~7 s MRI acquisition...
October 13, 2022: Tomography: a Journal for Imaging Research