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https://www.readbyqxmd.com/read/28521296/the-prognostic-value-of-long-non-coding-rnas-in-cervical-cancer-a-meta-analysis
#1
Xiangrong Cui, Xuan Jing, Xueqing Wu
Cervical cancer is one of the most common malignancies in women worldwide. Numerous literatures demonstrate that aberrantly expressed lncRNAs are involved in tumorigenesis and development, and may have the potential to be prognostic markers. However, their prognostic functions in cervical remain controversial. Therefore, we performed this meta-analysis to evaluate the prognostic significance of lncRNAs in cervical cancer. We searched databases to identify relevant articles. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated...
May 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28505621/gnrha-treatment-of-cryptorchid-boys-affects-genes-involved-in-hormonal-control-of-the-hpg-axis-and-fertility
#2
Faruk Hadziselimovic, Katharina Gegenschatz-Schmid, Gilvydas Verkauskas, Philippe Demougin, Vytautas Bilius, Darius Dasevicius, Michael B Stadler
The gonadotropin-releasing hormone agonist (GnRHa; Buserelin) rescues fertility during adulthood in the majority of high infertility risk cryptorchid boys presenting with defective mini-puberty. However, the molecular events governing this effect are not understood. We report the outcome of an RNA profiling analysis of testicular biopsies from 4 operated patients who were treated with GnRHa for 6 months versus 3 operated controls who were not treated. GnRHa induces a significant transcriptional response, including protein-coding genes involved in pituitary development, the hypothalamic-pituitary-gonadal axis, and testosterone synthesis...
May 16, 2017: Sexual Development: Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation
https://www.readbyqxmd.com/read/28500848/the-long-noncoding-rna-hotair-activates-the-hippo-pathway-by-directly-binding-to-sav1-in-renal-cell-carcinoma
#3
Guanghui Hu, Binbin Dong, Jingwei Zhang, Wei Zhai, Tiancheng Xie, Bisheng Huang, Chi Huang, Xudong Yao, Junhua Zheng, Jianping Che, Yun-Fei Xu
The long noncoding RNA HOTAIR promotes the development and progression of several tumors. Here, the clinical significance and role of HOTAIR in renal cell carcinoma (RCC) tumorigenesis were explored. The results showed that increased expression of HOTAIR predicted a poor prognosis of RCC after surgery. HOTAIR promoted RCC cell proliferation and growth in vitro and in vivo. The expressions of HOTAIR and Salvador homolog 1 (SAV1) were inversely correlated in clinical RCC samples. HOTAIR downregulated SAV1 by directly binding to the SAV1 protein and enhanced histone H3K27 methylation...
April 25, 2017: Oncotarget
https://www.readbyqxmd.com/read/28492542/lncrna-hotair-regulates-hif-1%C3%AE-axl-signaling-through-inhibition-of-mir-217-in-renal-cell-carcinoma
#4
Quan Hong, Ou Li, Wei Zheng, Wen-Zhen Xiao, Lu Zhang, Di Wu, Guang-Yan Cai, John Cijiang He, Xiang-Mei Chen
Long non-coding RNA HOTAIR was regarded as an oncogene in multiple cancers. Previous studies have shown that HOTAIR is involved in the proliferation and tumorigenesis of renal carcinoma cells, while microRNA (miR)-217 functions as a tumor suppressor in renal cell carcinoma (Rcc). However, the underlying molecular mechanism of HOTAIR in Rcc, especially in association with miR-217, has not been studied. In this study, we first demonstrated that HOTAIR expression was upregulated, which was correlated with tumor progression, and miR-217 downregulated in Rcc tissues and cells...
May 11, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28488843/hotair-and-gastric-cancer-a-lesson-from-two-meta-analyses
#5
Sharmila Fagoonee, Marilena Durazzo
No abstract text is available yet for this article.
May 8, 2017: Panminerva Medica
https://www.readbyqxmd.com/read/28484081/identification-of-aberrantly-expressed-long-non-coding-rnas-in-stomach-adenocarcinoma
#6
Jianbin Gu, Yong Li, Liqiao Fan, Qun Zhao, Bibo Tan, Kelei Hua, Guobin Wu
AIM: Stomach adenocarcinoma (STAD) is a common malignancy worldwide. This study aimed to identify the aberrantly expressed long non-coding RNAs (lncRNAs) in STAD. RESULTS: Total of 74 DElncRNAs and 449 DEmRNAs were identified in STAD compared with paired non-tumor tissues. The DElncRNA/DEmRNA co-expression network was constructed, which covered 519 nodes and 2993 edges. The qRT-PCR validation results of DElncRNAs were consistent with our bioinformatics analysis based on RNA-sequencing...
April 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28476883/the-long-non-coding-rna-hotair-enhances-pancreatic-cancer-resistance-to-tnf-related-apoptosis-inducing-ligand
#7
Shan-Zhong Yang, Fei Xu, Tong Zhou, Xinyang Zhao, Jay M McDonald, Yabing Chen
Pancreatic cancer is a malignant neoplasm with a high mortality rate. Therapeutic agents that activate TNF-related apoptosis inducing ligand (TRAIL)-induced apoptosis have shown promising efficacy, but many pancreatic cancers are resistant to TRAIL therapy. Epigenetic regulation plays important roles in tumor pathogenesis and resistance, and a recent study indicated that the long non-coding RNA HOX transcript antisense RNA (HOTAIR) is overexpressed in pancreatic cancer. However, the role of HOTAIR in pancreatic cancer resistance to anticancer agents is unknown...
May 5, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28454462/effects-of-irradiation-on-radioresistance-hotair-and-epithelial-mesenchymal-transition-cancer-stem-cell-marker-expression-in-esophageal-squamous-cell-carcinoma
#8
Chunli Da, Li Wu, Yuting Liu, Ruozheng Wang, Ruiguang Li
Radiotherapy is a common therapeutic strategy used to treat esophageal squamous cell carcinoma (ESCC). However, tumor cells often develop radioresistance, thereby reducing treatment efficacy. Here, we aimed to identify the mechanisms through which ESCC cells develop radioresistance and identify associated biomarkers. Eca109 cells were exposed to repeated radiation at 2 Gy/fraction for a total dose of 60 Gy (Eca109R60/2Gy cells). MTT and colony formation assays were performed to measure cell proliferation and compare the radiation biology parameters of Eca109 and Eca109R60/2Gy cells...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454226/long-non-coding-rna-hotair-enhances-radioresistance-in-mda-mb231-breast-cancer-cells
#9
Yun Zhou, Chaoqun Wang, Xia Liu, Chengjun Wu, Haitao Yin
The aim of the present study was to investigate the radiosensitizing effects of homeobox (HOX) transcript antisense RNA (HOTAIR) long non-coding RNA on breast cancer tumor cells and examine the underlying mechanisms. Recombinant plasmid vectors containing HOTAIR gene were constructed and MDA-MB231 cells were transfected with these plasmids using liposomes. The cells were treated with radiation and cell apoptosis, proliferation, and double-stranded DNA breaks were examined. HOXD10, phosphorylated AKT (p-AKT) and p-BAD expression levels were measured using western blot analysis...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28446530/long-non-coding-rnas-and-their-role-in-metastasis
#10
REVIEW
Ulrich H Weidle, Fabian Birzele, Gwen Kollmorgen, Rüdiger Rüger
The perception of long non-coding RNAs as chunk RNA and transcriptional noise has been steadily replaced by their role as validated targets for a diverse set of physiological processes in the past few years. However, for the vast majority of lncRNAs their precise mode of action and physiological function remain to be uncovered. A large body of evidence has revealed their essential role in all stages of cancirogenesis and metastasis. In this review we focus on the role of lncRNAs in metastasis. We grouped selected lncRNAs into three categories based on in vitro and in vivo mode of action-related studies and clinical relevance for metastasis...
May 2017: Cancer Genomics & Proteomics
https://www.readbyqxmd.com/read/28445933/the-long-noncoding-rna-hotair-promotes-parkinson-s-disease-by-upregulating-lrrk2-expression
#11
Sheng Wang, Xuan Zhang, Yuanyuan Guo, Han Rong, Tiebang Liu
Long noncoding RNAs (lncRNAs) have emerged recently as a new class of genes that regulate cellular processes. HOTAIR (Hox transcript antisense intergenic RNA), an approximately 2.2 kb long noncoding RNA transcribed from the HOXC locus, is upregulated in various diseases. However, the role of HOTAIR in Parkinson's disease (PD) remains unclear. A mouse model of PD was developed by intraperitoneal injection of MPTP. The expression of HOTAIR and LRRK2 were detected in the PD mice and in human neuroblastoma cell lines SH-SY5Y pretreated with MPP+...
April 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28441714/long-non-coding-rna-hotair-functions-as-mirna-sponge-to-promote-the-epithelial-to-mesenchymal-transition-in-esophageal-cancer
#12
Feng Xu, Jing Zhang
BACKGROUND: Accumulating evidence indicates dysregulated expression of the long non-coding RNA HOTAIR (lncRNA-HOTAIR) may play a significant role in tumor progression. LncRNA-HOTAIR promotes several processes in esophageal cancer (EC), including cell growth, differentiation, invasion and migration. However, the mechanisms by which lncRNA-HOTAIR promotes invasion and migration EC remain unclear. METHODS: LncRNA-HOTAIR and miR-148a expression were quantified in 40 paired human EC and tumor-adjacent tissues and EC cell lines by quantitative real-time PCR (qRT-PCR)...
June 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28420874/therapeutic-targeting-using-tumor-specific-peptides-inhibits-long-non-coding-rna-hotair-activity-in-ovarian-and-breast-cancer
#13
Ali R Özeş, Yinu Wang, Xingyue Zong, Fang Fang, Jay Pilrose, Kenneth P Nephew
Long non-coding RNAs (lncRNAs) play key roles in human diseases, including cancer. Functional studies of the lncRNA HOTAIR (HOX transcript antisense RNA) provide compelling evidence for therapeutic targeting of HOTAIR in cancer, but targeting lncRNAs in vivo has proven to be difficult. In the current study, we describe a peptide nucleic acids (PNA)-based approach to block the ability of HOTAIR to interact with EZH2 and subsequently inhibit HOTAIR-EZH2 activity and resensitize resistant ovarian tumors to platinum...
April 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28415631/lncrna-hotair-acts-a-competing-endogenous-rna-to-control-the-expression-of-notch3-via-sponging-mir-613-in-pancreatic-cancer
#14
Huihua Cai, Jie Yao, Yong An, Xuemin Chen, Weibo Chen, Di Wu, Boyang Luo, Yong Yang, Yong Jiang, Donglin Sun, Xiaozhou He
Pancreatic cancer is one of the most deadly cancers with a poor prognosis. Though studies have implicated the roles of microRNAs in pancreatic cancer progression, little is known about the role of miR-613 in pancreatic cancer. In the present study, the expression of miR-613 was down-regulated in pancreatic cancer tissues and cancer cell lines. Down-regulation of miR-613 was positively correlated with tumor differentiation, advanced TNM stage, nodal metastasis and shorter overall survival in patients with pancreatic cancer...
May 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28407576/hotair-may-regulate-proliferation-apoptosis-migration-and-invasion-of-mcf-7-cells-through-regulating-the-p53-akt-jnk-signaling-pathway
#15
Yang Yu, Feng Lv, Dong Liang, Qinheng Yang, Bin Zhang, Hong Lin, Xiaofang Wang, Guo Qian, Jinzhong Xu, Wei You
Breast cancer is a common malignancy, and it is the second leading cause of cancer-related death among women worldwide. The pathogenesis of breast cancer is poorly understood, leading to unsatisfactory efficacy of current anti-PC therapies. The aim of this study is to investigate the role of LncRNA HOTAIR in proliferation, apoptosis, migration and invasion of human breast cancer cell line MCF-7. MCF-7 cells were cultured and transfected with HOTAIR siRNA, and the proliferation rate of cells was determined using MTT and colony-forming assay; moreover, the apoptosis as well as cell cycles were determined using annexin V/propidium iodide staining methods and analyzed using flow cytometery; furthermore, cell scratch and transwell assays have been performed to examine the migration and invasion of MCF-7 cells; Next, cells were collected, and RT-qPCR as well as western blotting assay were performed to examine the expression of P53, MDM2, AKT, JNK, MMP-2 and MMP-9...
June 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28398609/potentially-functional-variants-in-lncrnas-are-associated-with-breast-cancer-risk-in-a-chinese-population
#16
Yue Jiang, Fangzhi Du, Fei Chen, Na Qin, Zhu Jiang, Jin Zhou, Tao Jiang, Zhening Pu, Yue Cheng, Jiaping Chen, Juncheng Dai, Hongxia Ma, Guangfu Jin, Zhibin Hu, Hao Yu, Hongbing Shen
Long non-coding RNAs (lncRNAs) participate in the development of breast cancer. Genetic variants in lncRNAs may be involved in their abnormal expressions and associated with cancer risk. In the present study, we performed RNA sequencing on five paired breast cancer tumor and adjacent non-cancerous tissues to obtain differentially expressed lncRNAs. We systematically selected potential regulatory variants of these lncRNAs and investigated the associations between these variants and breast cancer susceptibility in 1486 breast cancer cases and 1519 cancer-free controls in a Chinese population...
April 11, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28382860/dysregulation-of-lncrnas-in-placenta-and-pathogenesis-of-preeclampsia
#17
Xuejing Song, Xiucui Luo, Quansheng Gao, Yuhuan Wang, Qing Gao, Wei Long
Preeclampsia, a gestational disease characterized by hypertension and proteinuria twenty weeks into pregnancy, is one of the leading causes of fetal and maternal mortality. Although multiple genetic and environmental factors are found to be related to the preeclampsia risk, the pathogenic pathways remain largely undefined. The placenta plays a critical role in the fetal development by carrying out the barrier, fetal-maternal exchange, and endocrine functions during pregnancy. Accumulated data indicated that the expression of multiple long noncoding RNA (LncRNA) is dysregulated in preeclamptic placentas...
April 4, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28376832/serum-hotair-as-a-novel-diagnostic-biomarker-for-esophageal-squamous-cell-carcinoma
#18
Wenjian Wang, Xiaotian He, Zehua Zheng, Xiaofan Ma, Xueting Hu, Duoguang Wu, Minghui Wang
BACKGROUND: Early diagnosis of esophageal squamous cell carcinoma (ESCC) is an important issue to improve the prognosis. HOX transcript antisense RNA (HOTAIR), a long noncoding RNA (lncRNA) expressed from the HOXC locus, has been recently revealed as an oncogenic regulator in ESCC. This study aimed to investigate whether serum HOTAIR is involved in the diagnosis of ESCC. METHODS: In this study, we detected serum HOTAIR expression in 50 patients with ESCC (including 42 tumor resection and 8 without surgery) and 20 healthy volunteers to investigate the role of serum HOTAIR in ESCC using the quantitative real-time polymerase chain reaction (qRT-PCR) method...
April 4, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28364379/micror-545-mediates-colorectal-cancer-cells-proliferation-through-up-regulating-epidermal-growth-factor-receptor-expression-in-hotair-long-non-coding-rna-dependent
#19
Xinli Huang, Sen Lu
The functional impact of recently discovered miRNAs in human cancer remains to be clarified. One miRNA in colorectal cancer which has attracted attention is miR-545. In this study, we examined the function of miR-545 in proliferation of colorectal cancer cells. Expressions of HOTAIR, miRNA-545, and epidermal growth factor receptor (EGFR) mRNA were measured in 100 paired cancerous and non-cancerous tissues as well as in SW480 and LOVO colorectal cancer cell (CRC) lines by quantitative RT-PCR. The relative protein level of EGFR was measured using western blotting...
March 31, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28361920/sedentary-lifestyle-related-exosomal-release-of-hotair-from-gluteal-femoral-fat-promotes-intestinal-cell-proliferation
#20
Xiaozhao Lu, Danna Bai, Xiangwei Liu, Chen Zhou, Guodong Yang
Pioneering epidemiological work has established strong association of sedentary lifestyle and obesity with the risk of colorectal cancer, while the detailed underlying mechanism remains unknown. Here we show that Hotair (HOX transcript antisense RNA) is a pro-adipogenic long non-coding RNA highly expressed in gluteal-femoral fat over other fat depots. Hotair knockout in adipose tissue results in gluteal-femoral fat defect. Squeeze of the gluteal-femoral fat induces intestinal proliferation in wildtype mice, while not in Hotair knockout mice...
March 31, 2017: Scientific Reports
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