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https://www.readbyqxmd.com/read/27904706/the-central-role-of-hotair-in-the-malignancy-of-cd44-human-hypopharyngeal-carcinoma-cells
#1
Hongxia Cheng, Xinhua Cui, Ying Guo, Lintao Gu, Yaning Wang, Qirong Wang, Hui Liang
Human hypopharyngeal carcinoma is one of the most common malignant tumors. CD44 could serve as a molecular marker to screen for cancer stem cells (CSCs) in hypopharyngeal cancer. The aim of this study was to identify the role of HOX transcript antisense RNA (HOTAIR) on cell proliferation and invasion in CD44+ FADU cells (human hypopharyngeal carcinoma cells). We also explored the underlying mechanism contributing to HOTAIR's observed effects. CD44+ FADU cells were sorted and purified by flow cytometry and infected with lentivirus stably expressing HOTAIR shRNA...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27904675/expression-of-long-non-coding-rna-hotair-in-oral-squamous-cell-carcinoma-tca8113-cells-and-its-associated-biological-behavior
#2
Huawei Liu, Zhiyong Li, Chao Wang, Lin Feng, Haitao Huang, Changkui Liu, Fengxia Li
As a long noncoding RNA, HOX transcript antisense intergenic RNA (HOTAIR) is highly expressed in many types of tumors. However, its expression and function in oral squamous cell carcinoma (OSCC) cells and tissues remains largely unknown. We herein studied the biological functions of HOTAIR in OSCC Tca8113 cells. Real-time quantitative PCR showed that HOTAIR, p21 and p53 mRNA expressions in doxorubicin (DOX)-treated or γ-ray-irradiated Tca8113 cells were up-regulated. Knockdown of p53 expression inhibited DOX-induced HOTAIR up-regulation, suggesting that DNA damage-induced HOTAIR expression may be associated with p53...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27900563/lncrna-hotair-promotes-cisplatin-resistance-in-gastric-cancer-by-targeting-mir-126-to-activate-the-pi3k-akt-mrp1-genes
#3
Jin Yan, Yini Dang, Shiyu Liu, Yifeng Zhang, Guoxin Zhang
Altered expression of long noncoding RNAs (lncRNAs) has shown to associate with human cancer development and progression and drug resistance. LncRNA HOX antisense intergenic RNA (HOTAIR) regulates chromatin state and highly expressed in various human cancers. This study analyzed HOTAIR expression in gastric cancer cells and tissues and then assessed the effects of HOTAIR on modulation of gastric cancer cell sensitivity to cisplatin and the underlying molecular events. The data showed that HOTAIR was significantly upregulated in cisplatin-resistant gastric cancer cells and tissues compared with control cells and noncancerous gastric tissues...
November 30, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/27897239/expression-level-and-clinical-significance-of-hox-transcript-antisense-intergenic-rna-in-cervical-cancer-a-meta-analysis
#4
Shasha Liu, Min Zhang, Pengpeng Qu
The long noncoding RNA HOX transcript antisense intergenic RNA (HOTAIR) is associated with the development and progression of several types of cancer; however, its role in cervical cancer is unclear. Here, we performed a meta-analysis to evaluate the expression levels and clinical significance of HOTAIR in cervical cancer tissue. Relevant literature published by January 2016 was identified in PubMed, EMBase, National Knowledge Infrastructure, Wanfang Database, and Chinese Biomedical Literature Database. We performed statistical analysis, calculated standard mean differences (SMDs), and determined combined odds ratios (ORs) with 95% confidence intervals...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27895772/hotair-a-long-non-coding-rna-driver-of-malignancy-whose-expression-is-activated-by-foxc1-negatively-regulates-mirna-1-in-hepatocellular-carcinoma
#5
Dong-Na Su, Shi-Pin Wu, Hong-Tao Chen, Jin-Hua He
Evidence is rapidly accumulating that long non-coding RNAs (lncRNAs) are involved in human tumorigenesis and are dysregulated in multiple cancers, including hepatocellular carcinoma (HCC). lncRNAs can regulate essential pathways that contribute to tumor initiation and progression with tissue specificity, which suggests that lncRNAs may be valuable biomarkers and therapeutic targets. HOX transcript antisense intergenic RNA (HOTAIR) has previously been demonstrated to be an oncogene and a negative prognostic factor in a variety of cancers; however, the factors that contribute to the upregulation of HOTAIR and the interaction between HOTAIR and microRNAs (miRNAs or miRs) are largely unknown...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27895308/epigenetic-inhibition-of-mir-663b-by-long-non-coding-rna-hotair-promotes-pancreatic-cancer-cell-proliferation-via-up-regulation-of-insulin-like-growth-factor-2
#6
Huihua Cai, Yong An, Xuemin Chen, Donglin Sun, Tongbing Chen, Yan Peng, Feng Zhu, Yong Jiang, Xiaozhou He
Pancreatic cancer is one of the most deadly cancers with a poor prognosis. Although microRNAs are involving in the carcinogenesis and development of pancreatic cancer, little information is known regarding the role of miR-663b in pancreatic cancer. In this study, the expression of miR-663b in pancreatic cancer cells was down-regulated by hypermethylation in its putative promoter region, and overexpression of miR-663b repressed cell proliferation, invasion and migration, and induced apoptosis in pancreatic cancer cells...
November 22, 2016: Oncotarget
https://www.readbyqxmd.com/read/27875938/the-role-of-long-noncoding-rna-hotair-in-the-acquired-multidrug-resistance-to-imatinib-in-chronic-myeloid-leukemia-cells
#7
Haiying Wang, Qian Li, Shusen Tang, Meifang Li, Anhua Feng, Lili Qin, Zhiqiang Liu, Xin Wang
OBJECTIVES: Imatinib, a breakpoint cluster region-Abelson murine leukemia tyrosine kinase inhibitor, has revolutionized the treatment of chronic myelogenous leukemia (CML). However, the development of multidrug resistance (MDR) limits the clinical application of imatinib. In this study, we aimed to investigate the mechanisms of long noncoding RNA (lncRNA) HOTAIR in CML resistance to imatinib. METHODS: Thirty-four CML patients were divided into multidrug resistance protein 1 (MRP1)-low and MRP1-high groups according to the median expression...
November 22, 2016: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/27835600/yap1-enhances-cell-proliferation-migration-and-invasion-of-gastric-cancer-in-vitro-and-in-vivo
#8
Dan Sun, Xiaoting Li, Yingjian He, Wenhui Li, Ying Wang, Huan Wang, Shanshan Jiang, Yan Xin
Yes-associated protein 1 (YAP1) plays an important role in the development of carcinomas such as breast, colorectal, and gastric (GC) cancers, but the role of YAP1 in GC has not been investigated comprehensively. The present study strongly suggests that YAP1 and P62 were significantly up-regulated in GC specimens, compared with normal gastric mucosa. In addition, the YAP1high P62high expression was independently associated with poor prognosis in GC (hazard ratio: 1.334, 95% confidence interval: 1.045-1.704, P = 0...
November 7, 2016: Oncotarget
https://www.readbyqxmd.com/read/27819659/a-statistical-test-for-conserved-rna-structure-shows-lack-of-evidence-for-structure-in-lncrnas
#9
Elena Rivas, Jody Clements, Sean R Eddy
Many functional RNAs have an evolutionarily conserved secondary structure. Conservation of RNA base pairing induces pairwise covariations in sequence alignments. We developed a computational method, R-scape (RNA Structural Covariation Above Phylogenetic Expectation), that quantitatively tests whether covariation analysis supports the presence of a conserved RNA secondary structure. R-scape analysis finds no statistically significant support for proposed secondary structures of the long noncoding RNAs HOTAIR, SRA, and Xist...
November 7, 2016: Nature Methods
https://www.readbyqxmd.com/read/27816685/long-noncoding-rna-hotair-controls-cell-cycle-by-functioning-as-a-competing-endogenous-rna-in-esophageal-squamous-cell-carcinoma
#10
Kewei Ren, Yahua Li, Huibin Lu, Zongming Li, Zhen Li, Kai Wu, Zhiqin Li, Xinwei Han
Recent studies have shown that long noncoding RNAs (lncRNAs) play pivotal roles in the initiation and progression of cancer, including esophageal squamous cell carcinoma (ESCC). The lncRNA HOX transcript antisense RNA (HOTAIR) was reported to be dysregulated and correlated with the progression of ESCC. However, the biological role and the underlying mechanism of HOTAIR in the development of ESCC remain unclear. Herein, we found that HOTAIR was aberrantly upregulated in ESCC cells and that HOTAIR depletion inhibited proliferation and led to G1 cell cycle arrest in ESCC cells...
October 28, 2016: Translational Oncology
https://www.readbyqxmd.com/read/27810266/prognostic-role-of-lncrna-hotair-in-esophageal-squamous-cell-carcinoma
#11
REVIEW
Wei Song, Shu-Bing Zou
BACKGROUND: HOX transcript antisense intergenic RNA (HOTAIR) may be implicated in cancer development and progression. Clinical studies have suggested that HOTAIR may be related to poor prognosis in esophageal squamous cell carcinoma (ESCC). This study was designed to clarify the prognostic role of HOTAIR in ESCC. METHODS: MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials, and the China National Knowledge Infrastructure (CNKI) databases were searched to identify studies evaluating the prognostic significance of HOTAIR in ESCC...
November 1, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27791260/analyzing-37-900-samples-shows-significant-association-between-hotair-polymorphisms-and-cancer-susceptibility-a-meta-analysis
#12
Yating Ge, Runze Jiang, Meng Zhang, Hao Wang, Li Zhang, Jia Tang, Chaozhao Liang
BACKGROUND AND OBJECTIVE: An increasing number of investigations are drawing attention to the relationship between polymorphisms in the HOTAIR gene and the risk of cancers, but the results obtained so far have been controversial and inconclusive. We performed an up-to-date meta-analysis to obtain a more precise estimate of the possible associations. METHODS: Crude odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the strength of the associations...
October 22, 2016: International Journal of Biological Markers
https://www.readbyqxmd.com/read/27755794/circulating-long-non-coding-hox-transcript-antisense-intergenic-ribonucleic-acid-in-plasma-as-a-potential-biomarker-for-diagnosis-of-breast-cancer
#13
Yi Zhang, Kaijiong Zhang, Zhenglian Luo, Lian Liu, Lichun Wu, Jinbo Liu
BACKGROUND: It is well known that HOX transcript antisense intergenic ribonucleic acid (HOTAIR) plays an important role in breast cancer (BC). However, whether circulating HOTAIR in plasma could be used for BC diagnosis and dynamic monitoring are unclear. METHODS: We tested the expression levels of HOTAIR in 30 pairs of tissue samples and 148 plasma samples from BC patients by quantitative real time-polymerase chain reaction, and the correlation between plasma HOTAIR levels and clinical features were analyzed...
August 1, 2016: Thoracic Cancer
https://www.readbyqxmd.com/read/27751178/dioscin-inhibits-gastric-tumor-growth-through-regulating-the-expression-level-of-lncrna-hotair
#14
Ting Ma, Rui-Ping Wang, Xi Zou
BACKGROUND: As a member of non-coding RNAs family, long non-coding RNAs' functions in cancer needs to be further investigated. It has been indicated that the functions of Hox transcript antisense intergenic RNA (lncRNA: HOTAIR) include reprogramming chromatin organization and promoting tumor metastasis such as breast and colorectal tumor. The aim of this study is to investigate the functions of Hox in gastric cancer. METHODS: In the present study, the expression level of HOTAIR was determined by quantitative reverse transcription polymerase chain reaction (qRT-PCR), 20 gastric cancer tissues and 20 normal tissues was included...
September 30, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27748863/role-of-hotair-in-the-diagnosis-and-prognosis-of-acute-leukemia
#15
Yuan-Yuan Zhang, Si-Han Huang, Hua-Rong Zhou, Cong-Jie Chen, Li-Hong Tian, Jian-Zhen Shen
HOX antisense intergenic RNA (HOTAIR), a long non-coding RNA, plays an important role in the development of many types of cancers. Its function in acute leukemia (AL), however, has not been examined. The present study investigated the role of HOTAIR and its downstream genes in AL, and determined whether it could act as a molecular marker for prediction of leukemia development and prognosis. Real-time quantitative PCR was used to examine the expression of each gene in the HOTAIR signaling pathway in AL patients...
October 4, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27736969/downregulation-of-hotair-expression-mediated-anti-metastatic-effect-of-artesunate-on-cervical-cancer-by-inhibiting-cox-2-expression
#16
Lixin Zhang, Hua Qian, Min Sha, Zhengyun Luan, Mei Lin, Donglan Yuan, Xiaokang Li, Junxing Huang, Lihua Ye
Artesunate (ART) has anti-cancer activities for a variety of solid tumors. The aim of this study was to investigate the anti-metastatic effect of ART on cervical cancer cells. In vivo anti-metastatic effect of ART was investigated in mice with the lung metastasis model by the subcutaneous injection of ART. The interaction of HOTAIR and COX-2 was measured by RNA immunoprecipitation and RNA pull-down assay. The effect of ART on metastasis of CaSki and Hela cells was evaluated by invasion and migration assay. We found that ART inhibited cervical cancer metastasis and HOTAIR expression...
2016: PloS One
https://www.readbyqxmd.com/read/27695348/a-negative-regulation-loop-of-long-noncoding-rna-hotair-and-p53-in-non-small-cell-lung-cancer
#17
Nailiang Zhai, Yongfu Xia, Rui Yin, Jinping Liu, Fuquan Gao
Non-small-cell lung cancer (NSCLC) is one of the leading causes of cancer-related death worldwide, and the 5-year survival rate is still low despite advances in diagnosis and therapeutics. A long noncoding RNA (lncRNA) HOX antisense intergenic RNA (HOTAIR) has been revealed to play important roles in NSCLC carcinogenesis but the detailed mechanisms are still unclear. In the current study, we aimed to investigate the regulation between the lncRNA HOTAIR and p53 in the NSCLC patient samples and cell lines. Our results showed that HOTAIR expression was significantly higher in the cancer tissues than that in the adjacent normal tissue, and was negatively correlated with p53 functionality rather than expression...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27694625/challenges-of-crispr-cas9-applications-for-long-non-coding-rna-genes
#18
Ashish Goyal, Ksenia Myacheva, Matthias Groß, Marcel Klingenberg, Berta Duran Arqué, Sven Diederichs
The CRISPR/Cas9 system provides a revolutionary genome editing tool for all areas of molecular biology. In long non-coding RNA (lncRNA) research, the Cas9 nuclease can delete lncRNA genes or introduce RNA-destabilizing elements into their locus. The nuclease-deficient dCas9 mutant retains its RNA-dependent DNA-binding activity and can modulate gene expression when fused to transcriptional repressor or activator domains. Here, we systematically analyze whether CRISPR approaches are suitable to target lncRNAs...
September 30, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27690631/hotair-rs920778-polymorphism-is-associated-with-ovarian-cancer-susceptibility-and-poor-prognosis-in-a-chinese-population
#19
Haifeng Qiu, Xiujuan Wang, Ruixia Guo, Qiuli Liu, Yuan Wang, Zhongfu Yuan, Jing Li, Huirong Shi
AIM: The aim of this study was to determine if HOTAIR rs920778 polymorphism is associated with ovarian cancer susceptibility and prognosis. MATERIALS & METHODS: The data were obtained from two independent groups including 329 ovarian cancer patients and 680 cancer-free, age-matched women. Blood samples were collected and genomic DNA was extracted for genotyping. RESULTS: TT genotype and T allele of HOTAIR rs920778 were significantly associated with a decreased ovarian cancer risk (p = 0...
October 3, 2016: Future Oncology
https://www.readbyqxmd.com/read/27685928/association-of-the-hotair-rs4759314-polymorphism-with-cancer-risk-a-meta-analysis
#20
Fang-Teng Liu, Liang Zhou, Cheng Qiu, Guangfeng Xia, Pei-Qian Zhu, Hong-Liang Luo
PURPOSE: To explore the association between HOTAIR rs4759314 and cancer risk. METHODS: A comprehensive online search was conducted using PubMed, EMBASE, and CNKI databases to identify relevant studies. The case-control studies related to HOTAIR rs4759314 polymorphism and cancer risk were selected according to the inclusion and exclusion criteria. The retrieval time was until November 2015. After extracting the basic data information and performing an evaluation of the quality of the literature, the meta-analysis was performed using STATA 12...
July 2016: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
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