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https://www.readbyqxmd.com/read/28099173/surgical-approach-for-ulcerated-locally-advanced-breast-cancer-a-single-center-experience-a-retrospective-study
#1
Rita Laforgia, Clelia Punzo, Annunziata Panebianco, Annalisa Volpi, Marina Minafra, Maria Grazia Sederino
AIM: The aim of our retrospective study is to analyze surgical possibilities for the extended LABC in those cases not suitable for a neoadjuvant chemotherapy step and to consider various reconstruction techniques. MATERIAL OF STUDY: Between 2009 and 2015 we enrolled 11 patients, admitted to the Emergency Department, presenting ulcerated LABC that needed palliative surgical demolitive procedures because of bleeding and anemia and in which was necessary to use natural tissues transposition or synthetic substitutes for the reconstruction of the skin flaps...
January 12, 2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/28094868/biomaterials-a-potential-pathway-to-healing-chronic-wounds
#2
Mara A Pop, Benjamin D Almquist
Chronic dermal wounds are a devastating problem that disproportionally affect individuals with conditions such as diabetes, paralysis, or simply old age. These wounds are extremely challenging to treat due to a heterogeneous combination of causative factors, creating a substantial burden on healthcare systems worldwide. Despite their large impact, there is currently a startling lack of options for effectively treating the underlying biological changes that occur within the wounds. Biomaterials possess an enticing ability to provide new comprehensive approaches to healing these devastating wounds; advanced wound dressings are now being developed that enable the ability to coordinate temporal delivery of multiple therapeutics, protect sensitive biologics from degradation, and provide supportive matrices that encourage the growth of tissue...
January 17, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28090513/an-update-and-review-of-cell-based-wound-dressings-and-their-integration-into-clinical-practice
#3
REVIEW
Austin Pourmoussa, Daniel J Gardner, Maxwell B Johnson, Alex K Wong
Chronic wounds affect over 4 million individuals and pose a significant burden to the US healthcare system. Diabetes, venous stasis, radiation or paralysis are common risk factors for chronic wounds. Unfortunately, the current standard of care (SOC) has a high relapse rate and these wounds continue to adversely affect patients' quality of life. Fortunately, advances in tissue engineering have allowed for the development of cell-based wound dressings that promote wound healing by improving cell migration and differentiation...
December 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28079548/history-and-advancement-of-burn-treatments
#4
Hai-Fei Liu, Feng Zhang, William C Lineaweaver
Advances in burn care have accelerated within the last 50 years. The principal modalities of and approaches to burn treatment include dressings, antimicrobials, fluid resuscitation, burn wound excision, skin grafting, and use of skin substitutes. This review presents a historical outline of these approaches, their current status, and prospects for the future of burn care.
February 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28068055/development-of-advanced-dressings-for-the-delivery-of-progenitor-cells
#5
Giles T S Kirby, Stuart J Mills, Liesbeth Vandenpoel, Jef Pinxteren, Anthony Ting, Robert D Short, Allison J Cowin, Andrew Michelmore, Louise E Smith
Culture surfaces that substantially reduce the degree of cell manipulation in the delivery of cell sheets to patients are described. These surfaces support the attachment, culture, and delivery of multipotent adult progenitor cells (MAPC). It was essential that the processes of attachment/detachment to the surface did not affect cell phenotype nor the function of the cultured cells. Both acid-based and amine-based surface coatings were generated from acrylic acid, propanoic acid, diaminopropane, and heptylamine precursors, respectively...
January 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28025638/assessment-of-deep-partial-thickness-burn-treatment-with-keratin-biomaterial-hydrogels-in-a-swine-model
#6
D Poranki, C Goodwin, M Van Dyke
Partial thickness burns can advance to full thickness after initial injury due to inadequate tissue perfusion and increased production of inflammatory cytokines, which has been referred to as burn wound progression. In previous work, we demonstrated that a keratin biomaterial hydrogel appeared to reduce burn wound progression. In the present study, we tested the hypothesis that a modified keratin hydrogel could reduce burn wound progression and speed healing. Standardized burn wounds were created in Yorkshire swine and treated within 30 minutes with keratin hydrogel (modified and unmodified), collagen hydrogel, or silver sulfadiazine (SSD)...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27940041/thermosensitive-nanofibers-loaded-with-ciprofloxacin-as-antibacterial-wound-dressing-materials
#7
Heyu Li, Gareth R Williams, Junzi Wu, Yao Lv, Xiaozhu Sun, Huanling Wu, Li-Min Zhu
To obtain wound dressings which could be removed easily without secondary injuries, we prepared thermoresponsive electrospun fiber mats containing poly(di(ethylene glycol) methyl ether methacrylate) (PDEGMA). Blend fibers of PDEGMA and poly(l-lactic acid-co-ε-caprolactone) (P(LLA-CL) were fabricated via electrospinning, and analogous fibers containing the antibiotic ciprofloxacin (CIF) were also prepared. Smooth cylindrical fibers were obtained, albeit with a small amount of beading visible for the ciprofloxacin-loaded fibers...
December 6, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27865438/evaluation-of-bone-marrow-derived-mesenchymal-stem-cells-for-full-thickness-wound-healing-in-comparison-to-tissue-engineered-chitosan-scaffold-in-rabbit
#8
Mohammad Hossein Rajabian, Gholam Hossein Ghorabi, Bita Geramizadeh, Safoura Sameni, Maryam Ayatollahi
BACKGROUND: Chronic wounds present a major challenge in modern medicine. Even under optimal conditions, the healing process may lead to scarring and fibrosis. The ability of mesenchymal stem cells (MSCs) to differentiate into other cell types makes these cells an attractive therapeutic tool for cell transplantation. Both tissue-engineered construct and MSC therapy are among the current wound healing procedures and potential care. Chitosan has been widely applied in tissue engineering because of its biocompatibility and biodegradability...
November 9, 2016: Tissue & Cell
https://www.readbyqxmd.com/read/27843895/biomaterials-and-nanotherapeutics-for-enhancing-skin-wound-healing
#9
REVIEW
Subhamoy Das, Aaron B Baker
Wound healing is an intricate process that requires complex coordination between many cell types and an appropriate extracellular microenvironment. Chronic wounds often suffer from high protease activity, persistent infection, excess inflammation, and hypoxia. While there has been intense investigation to find new methods to improve cutaneous wound care, the management of chronic wounds, burns, and skin wound infection remain challenging clinical problems. Ideally, advanced wound dressings can provide enhanced healing and bridge the gaps in the healing processes that prevent chronic wounds from healing...
2016: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/27775985/a-brief-history-of-the-treatment-of-burns
#10
Hai-Fei Liu, Feng Zhang, William C Lineaweaver
Advances in burn care have a long history with accelerated development within the last 50 years. The principal areas of burn treatment include dressings, antimicrobials, fluid resuscitation, burn wound excision, grafting of skin, and skin substitution. This review presents a historical outline of these areas, their current status, and prospects for the future of burn care.
October 19, 2016: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/27745716/defocused-shock-wave-therapy-for-chronic-soft-tissue-wounds-in-the-lower-limbs-a-pilot-study
#11
Manuela Porso, Simona Loreti, Sveva Maria Nusca, Sara Luziatelli, Donatella Caccia, Giulia Taborri, Donatella Trischitta, Maurizio Taurino, Luca Padua, Vincenzo Maria Saraceni, Maria Chiara Vulpiani, Mario Vetrano
Chronic soft tissue wounds of the lower limbs are debilitating, painful and often unresponsive to advanced dressing treatments. Extracorporeal shock wave therapy (ESWT) could represent an alternative treatment. Ten patients with chronic soft tissue wounds of the legs, unresponsive to advanced dressing treatments for more than 3 mo, underwent three defocused ESWT sessions at 72-h intervals. In every session, the sum of 300 standard pulses + 100 pulses per square centimeter was applied at 0.15 mJ/mm(2) and 4 Hz over the edge of the wound...
January 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/27738884/a-regenerative-approach-with-dermal-micrografts-in-the-treatment-of-chronic-ulcers
#12
Francesco De Francesco, Antonio Graziano, Letizia Trovato, Gabriele Ceccarelli, Maurizio Romano, Marco Marcarelli, Gabriella Maria Cusella De Angelis, Umberto Cillo, Michele Riccio, Giuseppe Andrea Ferraro
BACKGROUND: The etiology of non-healing ulcers depends on both systemic and local factors. The introduction of advanced dressing, negative wound therapy and compression therapy have undoubtedly improved clinical outcomes. The principal aim of study was to demonstrate the efficacy of dermal micrografts in the treatment of ulcers with different etiologies. The second aim was to investigate in vitro the action of micrografts in the regenerative process. METHODS: The dermal micro-grafts were obtained from mechanical disaggregation of small pieces of skin tissue through a medical device called Rigeneracons...
October 13, 2016: Stem Cell Reviews
https://www.readbyqxmd.com/read/27720964/enhancing-effect-of-%C3%AE-cyclodextrin-on-wound-dressing-properties-of-sacran-hydrogel-film
#13
Nasrul Wathoni, Keiichi Motoyama, Taishi Higashi, Maiko Okajima, Tatsuo Kaneko, Hidetoshi Arima
A wound dressing is one of the essential approaches for preventing further harm to cutaneous wounds as well as promoting wound healing. Therefore, to achieve ideal wound healing, the development of advanced dressing materials is necessary. Recently, we revealed that a novel megamolecular polysaccharide, sacran, has potential properties as a biomaterial in a physically cross-linked hydrogel film (HGF) for wound dressing application. In this study, to enhance the wound-healing properties of sacran hydrogel film (Sac-HGF) further, we fabricated and characterized novel Sac-HGFs containing cyclodextrins (CyDs)...
January 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27646503/biocomposites-of-copper-containing-mesoporous-bioactive-glass-and-nanofibrillated-cellulose-biocompatibility-and-angiogenic-promotion-in-chronic-wound-healing-application
#14
Xiaoju Wang, Fang Cheng, Jun Liu, Jan-Henrik Smått, David Gepperth, Mika Lastusaari, Chunlin Xu, Leena Hupa
Biocomposites of copper-containing mesoporous bioactive glass (Cu-MBG) and nanofibrillated cellulose (NFC) were designated as potential dressing material for chronic wound healing. The phase composition and mesoporous micro-structure of the synthesized Cu-MBGs were elaborately characterized by combining several techniques, including TEM, SEM, XRD, SXAS and N2 physisorption. High bioactivity of the Cu-MBG was confirmed in stimulated body fluids in vitro. A controlled dissolution of Cu from the glass suggests Cu-MBG a suitable source for Cu release in wound healing dressings...
September 16, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27640245/current-advances-in-electrospun-gelatin-based-scaffolds-for-tissue-engineering-applications
#15
Ana A Aldana, Gustavo A Abraham
The development of biomimetic highly-porous scaffolds is essential for successful tissue engineering. Electrospun nanofibers are highly versatile platforms for a broad range of applications in different research areas. In the biomedical field, micro/nanoscale fibrous structures have gained great interest for wound dressings, drug delivery systems, soft and hard-tissue engineering scaffolds, enzyme immobilization, among other healthcare applications. In this mini-review, electrospun gelatin-based scaffolds for a variety of tissue engineering applications, such as bone, cartilage, skin, nerve, and ocular and vascular tissue engineering, are reviewed and discussed...
September 15, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27639216/physico-mechanical-morphological-and-biomedical-properties-of-a-novel-natural-wound-dressing-material
#16
Javad Tavakoli
Wound healing as a complex biological process greatly affects the quality of patients׳ lives. The high initial cost of wound treatment using advanced wound dressing is a major concern that warrants more attention. Because of the similarities between body macromolecules and polysaccharides and proteoglycans, gelatin and starch were used extensively as wound dressings; however their solubility in aqueous environment is known as a major drawback. Crosslinking, as a common method for enhancing mechanical properties, has its own limitation as some chemical cross-likers reduce biocompatibility...
January 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/27636330/poly-ethylene-glycol-based-hyperbranched-polymer-from-raft-and-its-application-as-a-silver-sulfadiazine-loaded-antibacterial-hydrogel-in-wound-care
#17
Sean McMahon, Robert Kennedy, Patrick Duffy, Jeddah Marie Vasquez, J Gerard Wall, Hongyun Tai, Wenxin Wang
A multifunctional branched copolymer was synthesized by Reversible Addition-Fragmentation Chain Transfer polymerization (RAFT) of poly(ethylene glycol) diacrylate (PEGDA Mn = 575) and poly(ethylene glycol) methyl methacrylate (PEGMEMA Mn = 500) at a feed molar ratio of 50:50. Proton nuclear magnetic resonance spectroscopy ((1)H NMR) confirmed a hyperbranched molecular structure and a high degree of vinyl functionality. An in situ cross-linkable hydrogel system was generated via a "click" thiol-ene-type Michael addition reaction of vinyl functional groups from this PEGDA/PEGMEMA copolymer system in combination with thiol-modified hyaluronic acid...
October 12, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27612753/development-of-hydrocolloid-bi-layer-dressing-with-bio-adhesive-and-non-adhesive-properties
#18
M Iqbal H Khan, Jahid M M Islam, Wasifa Kabir, Ataur Rahman, Maria Mizan, M Fizur Rahman, Jakia Amin, Mubarak A Khan
Bio-active bi-layer thin film having both bio-adhesive and non-adhesive end composed of polyvinyl alcohol (PVA) and gelatin/chitosan/polyethylene glycol (PEG) blend was developed for biomedical applications especially as an alternative of advanced tissue scaffold. The developed composite film was subjected to mechanical, thermal and physico-chemical characterization such as tensile strength (TS) and elongation at break (Eb), differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), fluid drainage capacity and biocompatibility...
December 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27602251/can-imaging-put-the-advanced-back-in-advanced-wound-care
#19
Ralph S DaCosta, Kathryn Ottolino-Perry, Jaideep Banerjee
An effective, scientifically validated, diagnostic tool helps clinicians make better, timely, and more objective medical decisions in the care of their patients. Today, the need for such tools is especially urgent in the field of wound care where patient-centric care is the goal, under ever tightening clinical budget constraints. In an era of countless "innovative" treatment options, that is, advanced dressings, negative pressure devices, and various debridement instruments available to the wound care clinical team, one area that has arguably languished in the past decade has been innovation in wound diagnostics...
August 1, 2016: Advances in Wound Care
https://www.readbyqxmd.com/read/27547189/engineered-biopolymeric-scaffolds-for-chronic-wound-healing
#20
REVIEW
Laura E Dickinson, Sharon Gerecht
Skin regeneration requires the coordinated integration of concomitant biological and molecular events in the extracellular wound environment during overlapping phases of inflammation, proliferation, and matrix remodeling. This process is highly efficient during normal wound healing. However, chronic wounds fail to progress through the ordered and reparative wound healing process and are unable to heal, requiring long-term treatment at high costs. There are many advanced skin substitutes, which mostly comprise bioactive dressings containing mammalian derived matrix components, and/or human cells, in clinical use...
2016: Frontiers in Physiology
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