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advance wound dressing

Edwin Tapiwa Chamanga
Chronic wounds are defined as those that have failed to heal after three months. There are various intrinsic and extrinsic factors that may result in the development of chronic wounds, including comorbidities such as diabetes mellitus and venous insufficiency, and lifestyle factors such as obesity, alcohol consumption and smoking. Chronic wounds represent a significant burden on healthcare resources and can have a negative effect on patients' quality of life. This article discusses the assessment and treatment of non-healing chronic wounds...
March 14, 2018: Nursing Standard
Anne-Claire Pierrefeu-Lagrange, Karine Mari, Caroline Hoss, Breda Cullen, Lorraine Nisbet
INTRODUCTION: Dressings are a mainstay for wound management; however, dressing adherence to the wound or periwound area can cause pain and trauma at removal. Dressing-related trauma includes skin reactions, adherence to the wound, and skin stripping. The development of atraumatic wound contact layer dressings has been a major advancement in reducing trauma. OBJECTIVE: This study compares the benefits of a cellulose acetate mesh (CAM) coated with soft silicone versus a flexible polyamide net (FPN) coated with soft silicone...
January 26, 2018: Wounds: a Compendium of Clinical Research and Practice
Xue Qu, Huan Liu, Chuchu Zhang, Yu Lei, Miao Lei, Miao Xu, Dawei Jin, Peng Li, Meng Yin, Gregory F Payne, Changsheng Liu
Electrical signals can be imposed with exquisite spatiotemporal control and provide exciting opportunities to create structure and confer function. Here, we report the use of electrical signals to program the fabrication of a chloramine wound dressing with high antimicrobial activity. This method involves two electrofabrication steps: (i) a cathodic electrodeposition of an aminopolysaccharide chitosan triggered by a localized region of high pH; and (ii) an anodic chlorination of the deposited film in the presence of chloride...
March 2, 2018: Acta Biomaterialia
Déborah Simões, Sónia P Miguel, Maximiano P Ribeiro, Paula Coutinho, António G Mendonça, Ilídio J Correia
Skin and soft tissue infections (SSTIs) have high rates of morbidity and mortality associated. Despite the successful treatment of some SSTIs, those affecting the subcutaneous tissue, fascia, or muscle delay the healing process and can lead to life-threatening conditions. Therefore, more effective treatments are required to deal with such pathological situations. Recently, wound dressings loaded with antimicrobial agents emerged as viable options to reduce wound bacterial colonization and infection, in order to improve the healing process...
February 17, 2018: European Journal of Pharmaceutics and Biopharmaceutics
Zhuo Zhang, Xiaolin Wang, Yitong Wang, Jingcheng Hao
To meet the progressive requirements of advanced engineering materials with superior physicochemical performances, self-healing and injectable hydrogels (AD hydrogels) based on agarose with pH-response were prepared through dynamic covalent Schiff-base linkages by simply mixing nontoxic agarose-ethylenediamine conjugate (AG-NH2) and dialdehyde-functionalized polyethylene glycol (DF-PEG) solutions. The self-healing and injectable capabilities of the hydrogels without any external stimulus are ascribed to dynamic covalent Schiff-base linkages between the aldehyde groups of DF-PEG and amine groups on AG-NH2 backbone...
February 16, 2018: Biomacromolecules
Angelica Panico, Federica Paladini, Mauro Pollini
Skin injuries represent a health problem with consequences in terms of morbidity, disability and life quality. Numerous strategies have been developed for the treatment of wounds, including skin substitutes, biomembranes, scaffolds, and smart dressings. The excellent properties of fibroin can be exploited for the development of advanced wound dressing biomaterials, aiming at promoting the wound healing process. In this work, silk fibroin films modified through the addition of glucose were developed to enhance flexibility of medical device without affecting the biocompatibility, to promote wound healing and to improve the patient well-being...
February 16, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Tamara Bernadette Aigner, Elise DeSimone, Thomas Scheibel
Silk is mostly known as a luxurious textile, which originates from silkworms first cultivated in China. A deeper look into the variety of silk reveals that it can be used for much more, in nature and by humanity. For medical purposes, natural silks were recognized early as a potential biomaterial for surgical threads or wound dressings; however, as biomedical engineering advances, the demand for high-performance, naturally derived biomaterials becomes more pressing and stringent. A common problem of natural materials is their large batch-to-batch variation, the quantity available, their potentially high immunogenicity, and their fast biodegradation...
February 13, 2018: Advanced Materials
Tatiana V Boyko, Michael T Longaker, George P Yang
Significance: The incidence of pressure ulcers is increasing due to our aging population and the increase in the elderly living with disability. Learning how to manage pressure ulcers appropriately is increasingly important for all professionals in wound care. Recent Advances: Many new dressings and treatment modalities have been developed over the recent years and the goal of this review is to highlight their benefits and drawbacks to help providers choose their tools appropriately. Critical Issues: Despite an increased number of therapies available on the market, none has demonstrated any clear benefit over the others and pressure ulcer treatment remains frustrating and time-consuming...
February 1, 2018: Advances in Wound Care
Ji-Ung Park, Seol-Ha Jeong, Eun-Ho Song, Juha Song, Hyoun-Ee Kim, Sukwha Kim
In this study, we evaluated the surface characterization of a novel chitosan-silica hybridized membrane and highlighted the substantial role of silica in the wound environment. The chemical coupling of chitosan and silica resulted in a more condensed network compared with pure chitosan, which was eventually able to stably maintain its framework, particularly in the wet state. In addition, we closely observed the wound-healing process along with the surface interaction between chitosan-silica and the wound site using large-surface-area wounds in a porcine model...
January 1, 2018: Journal of Biomaterials Applications
Eric L Johnson, Elisabet K Tassis, Georgina M Michael, Susan G Whittinghill
RATIONALE: Occupational burn injuries can be detrimental and difficult to manage. The majority of complex cases are referred and managed at regional burn centers where access to specialized care is available. As an alternative to hospitalization with staged surgical procedures, placental products may be used for outpatient medical management of these common burn injuries, especially if access to a regional burn center is limited or restricted.Fresh amnion has been a treatment of choice in burns for more than 100 years...
December 2017: Medicine (Baltimore)
Gregory A Bohn, Gregory S Schultz, Brock A Liden, Michael N Desvigne, Eric J Lullove, Igor Zilberman, Mary B Regan, Marta Ostler, Karen Edwards, Georgia M Arvanitis, Jodi F Hartman
Normal wound healing is accomplished through a series of well-coordinated, progressive events with overlapping phases. Chronic wounds are described as not progressing to healing or not being responsive to management in a timely manner. A consensus panel of multidisciplinary wound care professionals was assembled to (1) educate wound care practitioners by identifying key principles of the basic science of chronic wound pathophysiology, highlighting the impact of metalloproteinases and biofilms, as well as the role of the extracellular matrix; and (2) equip practitioners with a systematic strategy for the prevention and healing of acute injuries and chronic wounds based upon scientific evidence and the panel members' expertise...
November 2017: Wounds: a Compendium of Clinical Research and Practice
Peter Blume, Stephanie Wu
OBJECTIVE: Since the last diabetic foot ulcer (DFU) treatment algorithm was published in 2002, new options for diagnostic testing and treatments have been developed. This study seeks to update the DFU treatment algorithm to include new options available in diagnostic testing and treatment. MATERIALS AND METHODS: A computerized literature search of peer-reviewed articles published between January 2003 and January 2016 was conducted using MEDLINE (PubMed), EMBASE, and the Cochrane Library...
October 20, 2017: Wounds: a Compendium of Clinical Research and Practice
May S Freag, Ahmed O Elzoghby
BACKGROUND: recently, a great interest has been paid to the development of hybrid protein-inorganic nanoparticles (NPs) for tissue engineering applications to combine the merits of both inorganic and protein nanocarriers. OBJECTIVE: this short review primarily discusses the most important advances in the application of the hybrids of proteins (gelatin, zein, silk fibroin,….etc) with inorganic NPs (calcium phosphate NPs, cadmium QDs, carbon nanotubes,…etc) in tissue engineering...
October 27, 2017: Current Drug Targets
Shruti Chhabra, Naveen Chhabra, Avneet Kaur, Niti Gupta
BACKGROUND: Wound healing is a complex and dynamic process and a thorough knowledge of the basics of physiology of wound healing is a must to implement principles of chronic wound care. Understanding wound healing at multiple levels-biochemical, physiologic, cellular and molecular provides the surgeon with a framework for basing clinical decisions aimed at optimizing the healing response. OBJECTIVE: This review article describes the classification of wounds and aims to highlight the fundamentals of wound repair, enumerating the dressings used commonly and also, the newer concepts of wound healing...
December 2017: Journal of Maxillofacial and Oral Surgery
Minghan Hu, Karsten Korschelt, Phillip Daniel, Katharina Landfester, Wolfgang Tremel, Markus B Bannwarth
The concentrations of the redox pair hydrogen peroxide (H2O2) and oxygen (O2) can promote or decelerate the progression and duration of the wound healing process. Although H2O2 can reach critically high concentrations and prohibit healing, a sufficient O2 inflow to the wound is commonly desired. Herein, we describe the fabrication and use of a membrane that can contemptuously decrease H2O2 and increase O2 levels. Therefore, hematite nanozyme particles were integrated into electrospun and cross-linked poly(vinyl alcohol) membranes...
October 19, 2017: ACS Applied Materials & Interfaces
Ovidio Catanzano, Vittoria D'Esposito, Pietro Formisano, Joshua S Boateng, Fabiana Quaglia
The management of wounds in patients on anticoagulant therapy who require oral surgical procedures is problematic and often results in a non-satisfactory healing process. Here we report a method to prepare an advanced dressing able to avoid uncontrolled bleeding by occluding the post-extractive alveolar wounds, and simultaneously, capable of a fast release of tranexamic acid (TA). Composite alginate/hyaluronan (ALG/HA) sponge dressings loaded with TA were prepared by a straightforward internal gelation method followed by a freeze-drying step...
October 5, 2017: Journal of Pharmaceutical Sciences
Elizabeth Andersson Mattox
Negative-pressure wound therapy represents a relatively new strategy for wound management. Significant, life-threatening complications (bleeding, infection, and retained dressing material) have been associated with negative-pressure wound therapy. As a result, the Food and Drug Administration published several warnings to negative-pressure wound therapy users and recommended that clinicians ordering, managing, and/or monitoring negative-pressure wound therapy be aware of the potential complications and be prepared to take prompt action to reduce patients' risk for harm...
October 2017: Critical Care Nurse
Bahram Mirani, Erik Pagan, Barbara Currie, Mohammad Ali Siddiqui, Reihaneh Hosseinzadeh, Pooria Mostafalu, Yu Shrike Zhang, Aziz Ghahary, Mohsen Akbari
Wound management is a major global challenge and poses a significant financial burden to the healthcare system due to the rapid growth of chronic diseases such as diabetes, obesity, and aging population. The ability to detect pathogenic infections and release drug at the wound site is of the utmost importance to expedient patient care. Herein, this study presents an advanced multifunctional dressing (GelDerm) capable of colorimetric measurement of pH, an indicator of bacterial infection, and release of antibiotic agents at the wound site...
October 2017: Advanced Healthcare Materials
Alex Basu, Jaan Hong, Natalia Ferraz
The present work investigates Ca(2+) -crosslinked nanofibrillated cellulose hydrogels as potential hemostatic wound dressings by studying core interactions between the materials and a central component of wounds and wound healing-the blood. Hydrogels of wood-derived anionic nanofibrillated cellulose (NFC) and NFC hydrogels that incorporate kaolin or collagen are studied in an in vitro whole blood model and with platelet-free plasma assays. The evaluation of thrombin and factor XIIa formation, platelet reduction, and the release of activated complement system proteins, shows that the NFC hydrogel efficiently triggered blood coagulation, with a rapid onset of clot formation, while displaying basal complement system activation...
November 2017: Macromolecular Bioscience
Antonio Francesko, Petya Petkova, Tzanko Tzanov
Composed in a large extent of water and due to their non-adhesiveness, hydrogels found their way to the wound dressing market as materials that provide a moisture environment for healing while being comfortable to the patient. Hydrogels' exploitation is constantly increasing after evidences of their even broader therapeutic potential due to resemblance to dermal tissue and ability to induce partial skin regeneration. The innovation in advanced wound care is further directed to the development of so-called active dressings, where hydrogels are combined with components that enhance the primary purpose of providing a beneficial environment for wound healing...
September 20, 2017: Current Medicinal Chemistry
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