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https://www.readbyqxmd.com/read/28212691/efficacy-of-the-new-generation-of-devices-for-positional-therapy-for-patients-with-positional-obstructive-sleep-apnea-a-systematic-review-of-the-literature-and-meta-analysis
#1
Madeline J L Ravesloot, David White, Raphael Heinzer, Arie Oksenberg, Jean-Louis Pépin
STUDY OBJECTIVES: In approximately 56% to 75% of patients with obstructive sleep apnea (OSA), the frequency and duration of apneas are influenced by body position. This is referred to as position-dependent OSA or POSA. Patients with POSA can be treated with a small device attached to either the neck or chest. These devices-a new generation of devices for positional therapy (PT)-provide a subtle vibrating stimulus that prevents patients adopting the supine position. The objectives of this study were to determine whether PT is effective in improving sleep study variables and sleepiness, and to assess compliance...
February 15, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28208178/lingual-tonsillectomy-for-treatment-of-pediatric-obstructive-sleep-apnea-a-meta-analysis
#2
Kun-Tai Kang, Peter J Koltai, Chia-Hsuan Lee, Ming-Tzer Lin, Wei-Chung Hsu
Importance: Evidence indicates correlations between lingual tonsil hypertrophy and pediatric obstructive sleep apnea (OSA). However, to our knowledge, a meta-analysis of surgical outcomes for lingual tonsillectomy in children with OSA has not been conducted. Objective: To evaluate the therapeutic outcomes of lingual tonsillectomy for treatment of pediatric OSA. Data Sources: The study protocol was registered on PROSPERO (CRD42015027053). PubMed, MEDLINE, EMBASE, and the Cochrane Reviews databases were searched independently by 2 authors for relevant articles published by September 2016...
February 16, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28207995/impact-of-continuous-positive-airway-pressure-in-patients-with-obstructive-sleep-apnea-during-drug-induced-sleep-endoscopy
#3
Carlos Torre, Stanley Yung-Chuan Liu, Clete A Kushida, Vladimir Nekhendzy, Leh-Kiong Huon, Robson Capasso
OBJECTIVES: The primary objective of the study was to understand the differential impact of Continuous Positive Airway Pressure (CPAP) on the location, degree, and pattern of airway collapse in Obstructive Sleep Apnea (OSA) patients utilizing Drug Induced Sleep Endoscopy (DISE). STUDY DESIGN: Non-randomized trial. SETTING: University Medical Center. PARTICIPANTS: 15 consecutive OSA patients undergoing DISE. MAIN OUTCOMES AND MEASURES: The patterns of airway collapse were videorecorded at baseline and under differential application of nasal CPAP (nCPAP) at 5,10, and 15 cm H2 O...
February 16, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28207497/concurrent-presence-of-inflammation-and-obstructive-sleep-apnea-exacerbates-the-risk-of-metabolic-syndrome-a-koges-6-year-follow-up-study
#4
Jinkwan Kim, Dae Wui Yoon, Seung Ku Lee, Seunggwan Lee, Kyung-Mee Choi, Thomas J Robert, Chol Shin
Obstructive sleep apnea (OSA) leads to multiple end-organ morbidities that are mediated by the cumulative burden of oxidative stress and inflammation. Both OSA and inflammation play key roles in increased risk of cardiovascular disease (CVD). Thus, we hypothesized that the combination of inflammation and OSA could accelerate the development of metabolic syndrome (MetS) in a large cohort study.A total of 1835 participants were randomly selected from the ongoing Korean Genome and Epidemiology Study for the years between 2007 and 2015...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28206895/evaluation-of-current-screening-and-treatment-patterns-for-pediatric-obstructive-sleep-apnea-among-practicing-pediatric-dentists-in-the-united-states-a-pilot-study
#5
John Keating, Jae Hyun Park
PURPOSE: The purpose of this study was to provide an evaluation of educational experience, screening, referral, and treatment patterns by pediatric dentists in the United States with regards to obstructive sleep apnea (OSA) and sleep-disordered breathing (SDB). METHODS: A twenty-six question, multiple choice, electronic survey was developed using SurveyMonkey software. It was distributed to the 6,017 active American Academy of Pediatric Dentistry (AAPD) members, garnering a response rate of 7...
October 15, 2016: Pediatric Dentistry
https://www.readbyqxmd.com/read/28185814/obstructive-sleep-apnea-and-pulmonary-hypertension-in-children
#6
REVIEW
David G Ingram, Alvin V Singh, Zarmina Ehsan, Brian F Birnbaum
Obstructive sleep apnea (OSA) is a common pediatric breathing disorder, affecting 1-5% of all children. Pulmonary hypertension (PH), a severe complication of OSA, is associated with significant morbidity and mortality. Despite this important relationship between OSA and PH, there is sparse literature addressing this subject in children. This review will examine the putative relationship between OSA and PH, synthesize the available literature in children, and suggest a reasonable approach, despite limited data, for clinicians...
January 11, 2017: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/28185772/impact-of-weight-loss-management-in-osa
#7
REVIEW
Simon A Joosten, Garun S Hamilton, Matthew T Naughton
The interaction between obesity and obstructive sleep apnea (OSA) is complex. Whilst it is often assumed that obesity is the major cause of OSA, and that treatment of the OSA might mitigate further weight gain, new evidence is emerging that suggest these statements may not be the case. Obesity explains about 60% of the variance of the apnea hypopnea index definition of OSA, mainly in those < 50 years and less so in the elderly. Moreover, long term treatment of OSA with continuous positive airway pressure is associated with small but significant weight gain...
February 6, 2017: Chest
https://www.readbyqxmd.com/read/28183716/endothelial-dysfunction-in-children-with-obstructive-sleep-apnea-is-associated-with-elevated-lipoprotein-associated-phospholipase-a2-plasma-activity-levels
#8
Leila Kheirandish-Gozal, Mona F Philby, Zhuanghong Qiao, Abdelnaby Khalyfa, David Gozal
BACKGROUND: Obstructive sleep apnea (OSA) is a highly prevalent condition, especially in obese children, and has been associated with increased risk for endothelial dysfunction and dislipidemia, which are precursors of atherosclerosis. Lipoprotein-associated phospholipase A2 (Lp-PLA2) is recognized as an independent risk factor for cardiovascular risk and atheromatous plaque activity. We hypothesized that Lp-PLA2 levels would be elevated in children with OSA, particularly among obese children who also manifest evidence of endothelial dysfunction...
February 9, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28181141/does-post-operative-psychotherapy-contribute-to-improved-comorbidities-in-bariatric-patients-with-borderline-personality-disorder-traits-and-bulimia-tendencies-a-prospective-study
#9
Francesca Gallé, Pietro Maida, Assunta Cirella, Elena Giuliano, Patrizia Belfiore, Giorgio Liguori
BACKGROUND: Borderline personality disorder (BPD) and eating disorders may affect the outcomes of bariatric surgery. This study was aimed to evaluate the influence of a post-operative dialectical behavioral therapy (DBT) intervention on weight loss and comorbidities in a sample of comorbid obese Italian patients with BPD traits and bulimia tendencies who underwent laparoscopic Roux-en-Y gastric bypass (LRYGB) and laparoscopic adjustable gastric banding (LAGB). METHODS: One hundred fifty-four LRYGB or LAGB patients showing BPD and bulimia traits and type II diabetes, hypertension, and/or sleep apnea (OSAS) voluntarily adhered to DBT (n = 72) or treatment as usual (n = 82) for 12 months after surgery...
February 8, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28179438/management-of-continuous-positive-airway-pressure-treatment-compliance-using-telemonitoring-in-obstructive-sleep-apnoea
#10
Cecilia Turino, Jordi de Batlle, Holger Woehrle, Ana Mayoral, Anabel Lourdes Castro-Grattoni, Sílvia Gómez, Mireia Dalmases, Manuel Sánchez-de-la-Torre, Ferran Barbé
Continuous positive airway pressure (CPAP) is an effective treatment for obstructive sleep apnoea (OSA), but treatment compliance is often unsatisfactory. This study investigated the efficacy and cost-effectiveness of telemonitoring for improving CPAP compliance.100 newly diagnosed OSA patients requiring CPAP (apnoea-hypopnoea index >15 events·h(-1)) were randomised to standard management or a telemonitoring programme that collected daily information about compliance, air leaks and residual respiratory events, and initiated patient contact to resolve issues...
February 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28177762/chronic-intermittent-hypoxia-disturbs-insulin-secretion-and-causes-pancreatic-injury-via-mapk-signaling-pathway
#11
Yeying Wang, Bing Hai, Xiaoqun Niu, Li Ai, Yu Cao, Ran Li, Yongxia Li
Obstructive sleep apnea (OSA) is a breath disorder during sleep with a most prominent character of chronic intermittent hypoxia (CIH), inducing the generation of reactive oxygen species (ROS) to damage multiple tissues and cause metabolism disorders. In this study, we established rat varying OSA model by graded concentration of CIH (12.5% O2, 10% O2, 7.5%O2 and 5% O2) for 12 weeks, and found that CIH stimulated insulin secretion, reduced the insulin/proinsulin ratio in the pancreatic tissue, and caused pancreatic tissue lesions and cells apoptosis in a dose-dependent manner...
November 28, 2016: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28177331/the-role-of-masseter-muscle-emg-during-dise-to-predict-the-effectiveness-of-mad-preliminary-results
#12
M R Marchese, E Scarano, G Rizzotto, C Grippaudo, G Paludetti
The use of a mandibular advancement device (MAD) increases the activity of the temporo-mandibular (TM) complex and masseter (MM) muscles with the risk of reducing treatment compliance. Predictors of treatment outcome are of importance in selecting patients who might benefit from MAD without side effects. The role of mandibular advancement (MA) during drug-induced sleep endoscopy (DISE) is controversial. In three cases (BMI < 30) affected by non-severe OSAS (AHI < 30 e/h), we recorded the surface EMG signal of MM activity during DISE...
December 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/28168335/at-home-pulse-oximetry-in-children-undergoing-adenotonsillectomy-for-obstructive-sleep-apnea
#13
Martino Pavone, Nicola Ullmann, Elisabetta Verrillo, Giancarlo De Vincentiis, Emanuela Sitzia, Renato Cutrera
: Nocturnal pulse oximetry has a high positive predictive value for polysomnographically diagnosed obstructive sleep apnoea (OSA) in children. When significant adenotonsillar hypertrophy is diagnosed, adenotonsillectomy (T&A) represents a common treatment for OSA in children. We investigated the role of pulse oximetry in predicting those patients, referred for suspected OSA, who subsequently needed T&A. At-home nocturnal pulse oximetry was performed on 380 children (65.7% males), median age 4...
February 6, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28167000/urine-cysteinyl-leukotriene-levels-in-children-with-sleep-disordered-breathing-before-and-after-adenotonsillectomy
#14
A Satdhabudha, P Sritipsukho, S Manochantr, W Chanvimalueng, U Chaumrattanakul, P Chaumphol
OBJECTIVES: Obstructive sleep apnea (OSA) is a common problem in children and is associated with increased cardiovascular, neurobehavioral and somatic growth consequences. Cysteinyl leukotrienes (CysLTs) play a major role with local and systemic relations to the pathophysiology of OSA. The level of CysLTs in urine, blood, exhaled breath and adenotonsillar tissue of OSA children are increased. However it remains unclear whether inflammatory marker levels are alleviated after adenotonsillectomy...
March 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28162150/clinical-practice-guideline-for-diagnostic-testing-for-adult-obstructive-sleep-apnea-an-american-academy-of-sleep-medicine-clinical-practice-guidelin
#15
Vishesh K Kapur, Dennis H Auckley, Susmita Chowdhuri, David C Kuhlmann, Reena Mehra, Kannan Ramar, Christopher G Harrod
INTRODUCTION: This guideline establishes clinical practice recommendations for the diagnosis of obstructive sleep apnea (OSA) in adults and is intended for use in conjunction with other American Academy of Sleep Medicine (AASM) guidelines on the evaluation and treatment of sleep-disordered breathing in adults. METHODS: The AASM commissioned a task force of experts in sleep medicine. A systematic review was conducted to identify studies, and the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) process was used to assess the evidence...
January 31, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28162147/prevalence-and-associations-of-obstructive-sleep-apnea-in-south-asians-and-white-europeans-with-type-2-diabetes-a-cross-sectional-study
#16
Amin Amin, Asad Ali, Quratul A Altaf, Milan K Piya, Anthony H Barnett, Neil T Raymond, Abd A Tahrani
STUDY OBJECTIVES: To assess and compare obstructive sleep apnea (OSA) prevalence in South Asians and White Europeans with type 2 diabetes mellitus (T2DM). Secondary aims included exploring possible causes for observed ethnic differences. METHODS: A cross-sectional study of patients with T2DM recruited from secondary care diabetes clinics. OSA was defined as an apnea-hypopnea index (AHI) ≥ 5 events/h using home-based, multichannel respiratory monitoring. RESULTS: Two hundred thirty-four patients (105 South Asian and 129 White Europeans) were studied...
January 31, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28161892/osa-and-cardiometabolic-risk-what-s-the-bottom-line
#17
REVIEW
Camilla M Hoyos, Luciano F Drager, Sanjay R Patel
Obstructive sleep apnoea (OSA) is a common condition characterized by repetitive upper airway obstruction during sleep. OSA promotes wide intrathoracic pressure swings, intermittent hypoxia and sleep fragmentation. Growing evidence derived from animal models mimicking the oxygen profile observed in patients with OSA as well as clinical studies support that this important sleep-disordered breathing is associated with increased cardiovascular risk. Although the precise mechanisms are not fully established, it is conceivable that the metabolic deregulation promoted by the components of OSA may have an important causal role in the poor cardiovascular prognosis...
February 5, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28159093/legal-and-regulatory-aspects-of-sleep-disorders
#18
REVIEW
Saiprakash B Venkateshiah, Romy Hoque, Lourdes M DelRosso, Nancy A Collop
Sleep disorders may interact with the law, making awareness important. Insufficient sleep and obstructive sleep apnea (OSA) are prevalent and associated with excessive sleepiness. Patients with excessive sleepiness may have civil or criminal liability if they fall asleep and cause a motor vehicle accident. Awareness of screening and treatment of OSA is increasing in certain industries. Parasomnia associated sleep-related violence represents a challenge to clinicians, who may be called on to consider parasomnia as a contributing, mitigating, or exculpatory factor in criminal proceedings...
March 2017: Sleep Medicine Clinics
https://www.readbyqxmd.com/read/28159090/management-of-sleep-apnea-syndromes-in-heart-failure
#19
REVIEW
Bernardo J Selim, Kannan Ramar
Central sleep apnea (CSA) and obstructive sleep apnea (OSA) are prevalent in heart failure (HF) and associated with a worse prognosis. Nocturnal oxygen therapy may decrease CSA events, sympathetic tone, and improve left ventricular ejection fraction, although mortality benefit is unknown. Although treatment of OSA in patients with HF is recommended, therapy for CSA remains controversial. Continuous positive airway pressure use in HF-CSA may improve respiratory events, hemodynamics, and exercise capacity, but not mortality...
March 2017: Sleep Medicine Clinics
https://www.readbyqxmd.com/read/28158212/significant-improvement-of-olfactory-performance-in-sleep-apnea-patients-after-three-months-of-nasal-cpap-therapy-observational-study-and-randomized-trial
#20
Bettina Boerner, Gabrielo M Tini, Patrick Fachinger, Sereina M Graber, Sarosh Irani
OBJECTIVES: The olfactory function highly impacts quality of life (QoL). Continuous positive airway pressure is an effective treatment for obstructive sleep apnea (OSA) and is often applied by nasal masks (nCPAP). The influence of nCPAP on the olfactory performance of OSA patients is unknown. The aim of this study was to assess the sense of smell before initiation of nCPAP and after three months treatment, in moderate and severe OSA patients. METHODS: The sense of smell was assessed in 35 patients suffering from daytime sleepiness and moderate to severe OSA (apnea/hypopnea index ≥ 15/h), with the aid of a validated test battery (Sniffin' Sticks) before initiation of nCPAP therapy and after three months of treatment...
2017: PloS One
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