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Shaik Sameera, Pavuluri Aravind Kumar, Medandrao Nagasri, Pantareddy Indeevar, Kalapala Raviraj
Laser-assisted new attachment procedure (LANAP) is a new protocol that has been proposed for the treatment of periodontitis. However, there is little evidence regarding the rate of revascularization and the clinical efficacy of LANAP over conventional periodontal therapies. Hence, this study is done to evaluate and compare the clinical efficacy of LANAP vs Excisional new attachment procedure (ENAP) and also to assess the blood flow in both the techniques using ultrasound Doppler flowmetry. A split-mouth double-blinded controlled clinical trial was carried out in 15 subjects with chronic periodontitis...
February 1, 2018: Lasers in Medical Science
Suzanne Newkirk, Lynne Slim, Charles M Cobb
No abstract text is available yet for this article.
2015: Journal of the Western Society of Periodontology/Periodontal Abstracts
Todd McCracken
No abstract text is available yet for this article.
May 2014: Today's FDA: Official Monthly Journal of the Florida Dental Association
Marc Nevins, Soo-Woo Kim, Marcelo Camelo, Ignacio Sanz Martin, David Kim, Myron Nevins
This investigation was designed and implemented as a single-center, prospective study to evaluate the clinical response to the Laser-Assisted New Attachment Procedure (LANAP). Eight patients with advanced periodontitis were enrolled and treated with full-mouth LANAP therapy and monitored for 9 months. Fullmouth clinical measurements, including clinical attachment level (CAL), probing depth (PD), and recession, were provided at baseline and after 9 months of healing by a single calibrated examiner, including a total of 930 sites and 444 sites with initial PD equal to or greater than 5 mm...
January 2014: International Journal of Periodontics & Restorative Dentistry
David Mangot
No abstract text is available yet for this article.
November 2013: Dentistry Today
David Mangot
No abstract text is available yet for this article.
April 2013: Dentistry Today
Marc L Nevins, Marcelo Camelo, Peter Schupbach, Soo-Woo Kim, David M Kim, Myron Nevins
This investigation was designed to evaluate the healing response to the laser-assisted new attachment procedure (LANAP). Eight patients presenting with 12 teeth predetermined to be surgically extracted were enrolled and consented to treatment with full-mouth LANAP therapy. LANAP surgical therapy consisted of a first pass with a 360-Μm fiber diameter, laser settings with verified output of 4.0 W and energy density of 1,965 mJ/mm2, 100-Μs pulse duration, and 20 Hz applied from the gingival margin to the base of the pocket parallel to the root surface and moved laterally and apically to remove the diseased pocket epithelium...
October 2012: International Journal of Periodontics & Restorative Dentistry
Lloyd V Tilt
This study examines the effectiveness of the laser-assisted new attachment procedure (LANAP) as measured by tooth loss, comparing data to published studies using conventional surgical treatment modalities for the primary treatment of Types III and IV periodontitis. Retrospective data from 107 patients presenting with Types III and IV periodontitis were gathered and evaluated. All patients received LANAP periodontal therapy as their primary surgical treatment according to the FDA-cleared LANAP protocol. The patients averaged 6...
March 2012: General Dentistry
Jeffrey P Cranska
No abstract text is available yet for this article.
December 2009: Dentistry Today
Karin Koehler-Hansner, Ornella Flore, Bertram Opalka, Ulrich R Hengge
Human herpesvirus 8 (HHV-8) is associated with Kaposi's sarcoma, body cavity-based lymphoma, and Castleman's disease. Adenoviral (Ad) E1A proteins regulate the activity of cellular and viral promoters/enhancers and transcription factors and can suppress tumorigenicity of human cancers. As (i) HHV-8 and Ad may co-exist in immunocompromised patients and (ii) E1A might be considered as therapeutic transgene for HHV-8-associated neoplasms we investigated whether the promoter of the latency-associated nuclear antigen (LANAp) controlling expression of vCyclin, vFLIP, and LANA proteins required for latent type infection is regulated by E1A...
2008: Open Virology Journal
Raymond A Yukna, Ronald L Carr, Gerald H Evans
This report presents histologic results in humans following a laser-assisted new attachment procedure (LANAP) for the treatment of periodontal pockets. Six pairs of single-rooted teeth with moderate to advanced chronic periodontitis associated with subgingival calculus deposits were treated. A bur notch was placed within the pocket at the clinically and radiographically measured apical extent of calculus. All teeth were scaled and root planed with ultrasonic and hand scalers. One of each pair of teeth received treatment of the inner pocket wall with a free-running pulsed neodymium:yttrium-aluminum-garnet (Nd:YAG) laser to remove the pocket epithelium, and the test pockets were lased a second time to seal the pocket...
December 2007: International Journal of Periodontics & Restorative Dentistry
Michelle R Staudt, Dirk P Dittmer
Latent transcription of the latency-associated nuclear antigen (LANA/ORF73) of Kaposi's sarcoma-associated herpesvirus is driven by the LANAp-c. Complexity arises during lytic reactivation, however, as the bicistronic K14/vGPCR transcript initiates 32 bp downstream of LANAp-c in the opposite orientation. We identify an Rta/ORF50-inducible LANA promoter (LANAp-i) that is distinct from the LANAp-c. LANAp-c is unaffected by Rta/ORF50. Utilization of the second, downstream LANAp-i explains how LANA and K14/vGPCR are simultaneously transcribed during de novo infection or lytic reactivation...
June 20, 2006: Virology
David M Harris, Robert H Gregg, Delwin K McCarthy, Leigh E Colby, Lloyd V Tilt
Three private dental practices conducted a retrospective analysis of patients receiving the laser-assisted new attachment procedure (LANAP). Retrospective results were compared to clinical trial data from the University of Texas Health Sciences Center in San Antonio (UTHSCSA) to determine if outcomes from a controlled clinical trial can be duplicated in private practice. Results also are compared with published results of other surgical and nonsurgical therapies for inflammatory periodontal disease.
September 2004: General Dentistry
Joseph H Jeong, Joshua Orvis, Jong Wook Kim, Curtis P McMurtrey, Rolf Renne, Dirk P Dittmer
Kaposi's sarcoma-associated herpesvirus (KSHV) or human herpesvirus 8 has been established as the etiological agent of Kaposi's sarcoma and certain AIDS-associated lymphomas. KSHV establishes latent infection in these tumors, invariably expressing high levels of the viral latency-associated nuclear antigen (LANA) protein. LANA is necessary and sufficient to maintain the KSHV episome. It also modulates viral and cellular transcription and has been implicated directly in oncogenesis because of its ability to bind to the p53 and pRb tumor suppressor proteins...
April 16, 2004: Journal of Biological Chemistry
J Jeong, J Papin, D Dittmer
Similar to that of other herpesviruses, Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) lytic replication destroys the host cell, while the virus can persist in a latent state in synchrony with the host. During latency only a few genes are transcribed, and the question becomes one of what determines latent versus lytic gene expression. Here we undertake a detailed analysis of the latency-associated nuclear antigen (LANA [orf73]) promoter (LANAp). We characterized a minimal region that is necessary and sufficient to maintain high-level transcription in all tissues tested, including primary endothelial cells and B cells, which are the suspected natural host for KSHV...
February 2001: Journal of Virology
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