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Gantas Perez-Mockus, Vanessa Roca, Khalil Mazouni, François Schweisguth
Crumbs (Crb) is a conserved determinant of apical membrane identity that regulates epithelial morphogenesis in many developmental contexts. In this study, we identify the Crb complex protein Stardust (Sdt) as a target of the E3 ubiquitin ligase Neuralized (Neur) in Drosophila melanogaster Neur interacts with and down-regulates specific Sdt isoforms containing a Neur binding motif (NBM). Using a CRISPR (clustered regularly interspaced short palindromic repeats)-induced deletion of the NBM-encoding exon, we found that Sdt is a key Neur target and that Neur acts via Sdt to down-regulate Crb...
May 1, 2017: Journal of Cell Biology
Jan Rusz, Michal Novotny, Jan Hlavnicka, Tereza Tykalova, Evzen Ruzicka
Recently, based on voice cepstral analysis, Benba et al. (IEEE T. Neur. Sys. Reh., vol. 24, pp. 1100-1108, 2016) have reported discrimination between patients with Parkinson's disease and different neurological disorders with high classification accuracy up to 90%. Using the same approach, we were able to experimentally separate two groups of normal healthy speakers with 96% classification accuracy and showed that the method proposed by Benba et al. may not be appropriate for discrimination between different neurological diseases...
October 26, 2016: IEEE Transactions on Neural Systems and Rehabilitation Engineering
Jan Rusz, Michal Novotny, Jan Hlavnicka, Tereza Tykalova, Evzen Ruzicka
Recently, based on voice cepstral analysis, Benba et al. (IEEE T. Neur. Sys. Reh., vol. 24, pp. 1100-1108, 2016) have reported discrimination between patients with Parkinson's disease and different neurological disorders with high classification accuracy up to 90%. Using the same approach, we were able to experimentally separate two groups of normal healthy speakers with 96% classification accuracy and showed that the method proposed by Benba et al. may not be appropriate for discrimination between different neurological diseases...
October 26, 2016: IEEE Transactions on Neural Systems and Rehabilitation Engineering
Kristina Endres, Sven Reinhardt, Anastasia Geladaris, Julia Knies, Marcus Grimm, Tobias Hartmann, Ulrich Schmitt
BACKGROUND: Murine models of Alzheimer's disease (AD) are mainly based on overexpression of pathologic amyloid precursor protein and/or presenilins. Those genes resemble underlying cause of early onset type of AD while about 99 % of all human cases are to be characterized as sporadic, late onset. Appropriate animal models for this type of AD are still missing. We here investigated, if transnasal delivery of A-beta 42 peptides might serve to mimic pathological effects in mice. RESULTS: A-beta 42 peptides, used for the behavioral study, showed the expected dose-dependent toxicity in neur oblastoma cell line SH-SY5Y and were able to form higher molecular weight species in vitro...
2016: BMC Neuroscience
X He, S Zhou, G E St Armour, T F C Mackay, R R H Anholt
The extent to which epistasis affects the genetic architecture of complex traits is difficult to quantify, and identifying variants in natural populations with epistatic interactions is challenging. Previous studies in Drosophila implicated extensive epistasis between variants in genes that affect neural connectivity and contribute to natural variation in olfactory response to benzaldehyde. In this study, we implemented a powerful screen to quantify the extent of epistasis as well as identify candidate interacting variants using 203 inbred wild-derived lines with sequenced genomes of the Drosophila melanogaster Genetic Reference Panel (DGRP)...
February 2016: Genes, Brain, and Behavior
Paul Gozzard, Caroline Chapman, Angela Vincent, Bethan Lang, Paul Maddison
PURPOSE: Favourable small cell lung carcinoma (SCLC) survival outcomes have been reported in patients with paraneoplastic neurological disorders (PNDs) associated with neuronal antibodies (Neur-Abs), but the presence of a PND might have expedited diagnosis. Our aim was to establish whether neuronal antibodies, independent of clinical neurological features, correlate with SCLC survival. EXPERIMENTAL DESIGN: 262 consecutive SCLC patients were examined: of these, 24 with neurological disease were excluded from this study...
2015: PloS One
Jingwen Zhou, Jiahui Wu, Jintao Zhang, Tan Xu, Huan Zhang, Yonghong Zhang, Shaoyan Zhang
BACKGROUND: To investigate the association of short-term clinical outcomes with coexistence of hyperglycemia and elevated biomarkers of inflammation among acute ischemic stroke (AIS) patients. METHODS: We performed a retrospective study of 2675 patients diagnosed with AIS from January 2006 to December 2008. The study outcomes were defined as neurologic deficiency (National Institutes of Health Stroke Scale score ≥5) at discharge or death during hospitalization...
June 2015: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Toru Sasaki, Masafumi Yamanaka, Nobuyuki Kagami
The Publisher regrets that this article is an accidental duplication of an article that has already been published, The duplicate article has therefore been withdrawn.
December 12, 2012: Neuroscience Research
Marianne Udd, Outi Lindström, Harri Mustonen, Leif Bäck, Jorma Halttunen, Leena Kylänpää
OBJECTIVE: Percutaneous endoscopic gastrostomy (PEG) is used for long-term enteral nutrition in neurological patients with dysphagia (NEUR), in head and neck cancer patients prior to chemoradiation therapy (head and neck malignancy group [HNM]), or in cases of oropharyngeal or esophageal tumor obstruction or stricture (OBSTR). Considerable morbidity and overall mortality is reported. Aim was to analyze the complication rates and mortality with PEG and to identify subgroups with poor outcomes...
February 2015: Scandinavian Journal of Gastroenterology
Steven W Miller, Mark Rebeiz, Jenny E Atanasov, James W Posakony
Transcriptional cis-regulatory modules (CRMs), or enhancers, are responsible for directing gene expression in specific territories and cell types during development. In some instances, the same gene may be served by two or more enhancers with similar specificities. Here we show that the utilization of dual, or "shadow", enhancers is a common feature of genes that are active specifically in neural precursor (NP) cells in Drosophila. By genome-wide computational discovery of statistically significant clusters of binding motifs for both proneural activator (P) proteins and basic helix-loop-helix (bHLH) repressor (R) factors (a "P+R" regulatory code), we have identified NP-specific enhancer modules associated with multiple genes expressed in this cell type...
December 2, 2014: Proceedings of the National Academy of Sciences of the United States of America
Lei Bi, Jinman Kim, Dagan Feng, Michael Fulham
Positron emission tomography computed tomography (PET-CT) is the preferred imaging modality for the evaluation of the lymphomas. Disease involvement in the lymphomas usually appear as foci of increased Fluorodeoxyglucose (FDG) uptake. Thresholding methods are applied to separate different regions of involvement. However, the main limitation of thresholding is that it also includes regions where there is normal FDG excretion and FDG uptake (NEUR) in structures such as the brain, bladder, heart and kidneys. We refer to these regions as NEURs (the normal excretion and uptake (of FDG) regions)...
2014: Medical Image Computing and Computer-assisted Intervention: MICCAI ..
Chiyedza Small, Johnny Ramroop, Maria Otazo, Lawrence H Huang, Shireen Saleque, Shubha Govind
A fundamental question in hematopoietic development is how multipotent progenitors achieve precise identities, while the progenitors themselves maintain quiescence. In Drosophila melanogaster larvae, multipotent hematopoietic progenitors support the production of three lineages, exhibit quiescence in response to cues from a niche, and from their differentiated progeny. Infection by parasitic wasps alters the course of hematopoiesis. Here we address the role of Notch (N) signaling in lamellocyte differentiation in response to wasp infection...
June 2014: Genetics
Zhouheng Ye, Rongjia Zhang, Xuejun Sun
Argon is a noble gas in group 18 of the periodic table. Certificated to exist in air atmosphere merely one century ago, discovery of argon shows interesting stories of researching and exploring. It was assumed to have no chemical activity. However, argon indeed present its biological effect on mammals. Narcotic effect of argon in diving operation and neur-protective function of argon in cerebral injury demonstrate that argon has crucial effect and be concentrated on is necessary. Furthermore, consider to be harmless to human, argon clinical application in therapy would be another option...
2013: Medical Gas Research
Jia-kai Ye, Jin-tao Zhang, Yan Kong, Tan Xu, Ting-ting Zou, Yong-hong Zhang, Shao-yan Zhang
OBJECTIVE: To investigate the relationship between white blood cell count, neutrophils ratio and erythrocyte sedimentation rate and short outcomes among patients with acute ischemic stroke at admission to the hospital. METHODS: A total of 2675 acute ischemic stroke patients were included in this study. Data on demographic characteristics, life style, history of disease, white blood cell count (WBC), neutrophils ratio (NEUR), erythrocyte sedimentation rate (ESR) and clinical outcomes were collected for all the participants...
September 2012: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
Sili Liu, Julia Maeve Bonner, Soline Chanet, Cosimo Commisso, Lara C Skwarek, François Schweisguth, Gabrielle L Boulianne
The Notch pathway plays an integral role in development by regulating cell fate in a wide variety of multicellular organisms. A critical step in the activation of Notch signaling is the endocytosis of the Notch ligands Delta and Serrate. Ligand endocytosis is regulated by one of two E3 ubiquitin ligases, Neuralized (Neur) or Mind bomb. Neur is comprised of a C-terminal RING domain, which is required for Delta ubiquitination, and two Neur homology repeat (NHR) domains. We have previously shown that the NHR1 domain is required for Delta trafficking...
December 2012: Molecular and Cellular Biology
Mónica S Ventura Ferreira, Willi Jahnen-Dechent, Norina Labude, Manfred Bovi, Thomas Hieronymus, Martin Zenke, Rebekka K Schneider, Sabine Neuss, Sabine Neurs
Expansion of multipotent, undifferentiated and proliferating cord blood (CB)-hematopoietic stem cells (HSC) in vitro is limited and insufficient. Bone marrow (BM) engineering in vitro allows mimicking the main components of the hematopoietic niche compared to conventional expansion strategies. In this study, four different 3D biomaterial scaffolds (PCL, PLGA, fibrin and collagen) were tested for freshly isolated cord blood (CB)-CD34(+) cell expansion in presence of (i) efficient exogenous cytokine supplementation and (ii) umbilical cord (UC)-mesenchymal stem cells (MSC)...
October 2012: Biomaterials
Aikaterini Daskalaki, Nevine A Shalaby, Kristina Kux, Giorgos Tsoumpekos, George D Tsibidis, Marc A T Muskavitch, Christos Delidakis
DSL proteins are transmembrane ligands of the Notch receptor. They associate with a RING (really interesting new gene) family E3 ubiquitin ligase, either Neuralized (Neur) or Mindbomb 1 (Mib1), as a prerequisite to signaling. Although Neur and Mib1 stimulate internalization of DSL ligands, it is not known how ubiquitylation contributes to signaling. We present a molecular dissection of the intracellular domain (ICD) of Drosophila melanogaster Delta (Dl), a prototype DSL protein. Using a cell-based assay, we detected ubiquitylation of Dl by both Neur and Mib1...
December 12, 2011: Journal of Cell Biology
Krishna Moorthi Bhat, Ivana Gaziova, Sumana Katipalla
In the CNS, the evolutionarily conserved Notch pathway regulates asymmetric cell fate specification to daughters of ganglion mother cells (GMCs). The E3 Ubiquitin ligase protein Neuralized (Neur) is thought to activate Notch-signaling by the endocytosis of Delta and the Delta-bound extracellular domain of Notch. The intracellular Notch then initiates Notch-signaling. Numb blocks N-signaling in one of the two daughters of a GMC, allowing that cell to adopt a different identity. Numb is asymmetrically localized in a GMC and is segregated to only one of the two daughter cells...
March 1, 2011: Developmental Biology
Davis L Reames, Justin S Smith, Kai-Ming G Fu, David W Polly, Christopher P Ames, Sigurd H Berven, Joseph H Perra, Steven D Glassman, Richard E McCarthy, Raymond D Knapp, Robert Heary, Christopher I Shaffrey et al.
STUDY DESIGN: Retrospective review of a multicenter database. OBJECTIVE: To determine the complication rates associated with surgical treatment of pediatric scoliosis and to assess variables associated with increased complication rates. SUMMARY OF BACKGROUND DATA: Wide variability is reported for complications associated with the operative treatment of pediatric scoliosis. Limited number of patients, surgeons, and diagnoses occur in most reports...
August 15, 2011: Spine
Kai Michael Kompisch, Claudia Lange, Doris Steinemann, Britta Skawran, Brigitte Schlegelberger, Reinhard Müller, Udo Schumacher
Adipose-derived stem cells (ASCs) are reported to display multilineage differentiation potential, including neuroectodermal pathways. The aim of the present study was to critically re-evaluate the potential neurogenic (trans-)differentiation capacity of ASCs using a neurogenic induction protocol based on the combination of isobutylmethylxanthine (IBMX), indomethacin and insulin. ASCs isolated from lipo-aspirate samples of five healthy female donors were characterized and potential neurogenic (trans-)differentiation was assessed by means of immunohistochemistry and gene expression analyses...
November 2010: Histochemistry and Cell Biology
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