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Aortic dissection

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https://www.readbyqxmd.com/read/29909014/non-coding-rnas-in-aneurysmal-aortopathy
#1
REVIEW
Joshua M Spin, Daniel Y Li, Lars Maegdefessel, Philip S Tsao
Aortic aneurysms represent a major public health burden, and currently have no medical treatment options. The pathophysiology behind these aneurysms is complex and variable, depending on location and underlying cause, and generally involves progressive dysfunction of all elements of the aortic wall. Changes in smooth muscle behavior, endothelial signaling, extracellular matrix remodeling, and to a variable extent inflammatory signaling and cells, all contribute to the dilation of the aorta, ultimately resulting in high mortality and morbidity events including dissection and rupture...
June 14, 2018: Vascular Pharmacology
https://www.readbyqxmd.com/read/29908163/matrix-metalloproteinases-are-regulated-by-microrna-320-in-macrophages-and-are-associated-with-aortic-dissection
#2
Mingfang Liao, Sili Zou, Yan Bao, Jie Jin, Junlin Yang, Yandong Liu, Mark Green, Futang Yang, Lefeng Qu
Aortic dissection (AD) is the circumferential or transversal tear of the aorta wall that allows blood to infiltrate the layers. MicroRNA (miR) analyses have demonstrated a correlation between miR-320 family and AD. The underlying mechanism is yet unclear. The matrix metalloproteinases (MMPs) are a group of proteolytic enzymes that could catalyze the degeneration of the extracellular matrix and the destruction of the vasculature. In this study, we investigated whether miR-320 presented a role in regulating the production of MMPs in aortic dissection...
June 13, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29904982/dissecting-the-evidence-on-aortic-catastrophe
#3
Robert R Ehrman, Mark J Favot, Adrienne Malik
Acute aortic dissection presents a diagnostic challenge for Emergency Physicians. Use of recently published "high-risk" features to identify patients as truly high-risk may lead to over-testing. This article is protected by copyright. All rights reserved.
June 14, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29904981/diagnosing-acute-aortic-dissection-both-an-artery-and-a-science
#4
Robert Ohle
Thank you very much for your interest in our paper. We agree that retrospective nature of this study in isolation does not provide proof of a hypothesis. However taken in context of the evidence as quoted in the paper and the new prospective trial by Nazerian et al, we believe it adds to the conversation that classically reported high risk features do in fact change the likelihood of acute aortic dissection. This article is protected by copyright. All rights reserved.
June 14, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29904131/quantitative-study-of-abdominal-blood-flow-patterns-in-patients-with-aortic-dissection-by-4-dimensional-flow-mri
#5
Dongting Liu, Zhanming Fan, Yu Li, Nan Zhang, Zhonghua Sun, Jing An, Aurélien F Stalder, Andreas Greiser, Jiayi Liu
The purpose of this study is to evaluate the hemodynamic characteristics of the true lumen (TL) and the false lumen (FL) in 16 patients with aortic dissection (AD) using 4D flow magnetic resonance imaging (MRI) and thoracic and abdominal computed tomography (CT) angiography. The quantitative parameters that were measured in the TL and FL included velocity and flow. The mean area and regurgitant fraction of the TL were significantly lesser at all four levels (p < 0.05); the average through-plane velocity, peak velocity magnitude, average net flow, peak flow, and net forward volume in the TL were considerably higher (p < 0...
June 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29903350/acute-limited-intimal-tears-of-the-thoracic-aorta
#6
Anne S Chin, Martin J Willemink, Aya Kino, Virginia Hinostroza, Anna M Sailer, Michael P Fischbein, R Scott Mitchell, Gerald J Berry, D Craig Miller, Dominik Fleischmann
BACKGROUND: Limited intimal tears (LITs) of the aorta (Class 3 dissection variant) are the least common form of aortic pathology in patients presenting with acute aortic syndrome (AAS). LITs are difficult to detect on imaging and may be underappreciated. OBJECTIVES: This study sought to describe the frequency, pathology, treatment, and outcome of LITs compared with other AAS, and to demonstrate that LITs can be detected pre-operatively by contemporary imaging. METHODS: The authors retrospectively reviewed 497 patients admitted for 513 AAS events at a single academic aortic center between 2003 and 2012...
June 19, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29898464/impact-of-different-aortic-entry-tear-sites-on-early-outcomes-and-long-term-survival-in-patients-with-stanford-a-acute-aortic-dissection
#7
Julia Merkle, Anton Sabashnikov, Antje Christin Deppe, Saskia Weber, Navid Mader, Yeong-Hoon Choi, Oliver Liakopoulos, Ferdinand Kuhn-Régnier, Thorsten Wahlers
BACKGROUND:  Stanford A acute aortic dissection (AAD) is a life-threatening emergency. The aim of this study was to compare the impact of three different aortic entry tear sites on early outcomes and long-term survival of patients with Stanford A AAD. METHODS:  From January 2006 to April 2015, a total of 240 consecutive patients with diagnosed Stanford A AAD underwent emergent, isolated surgical aortic repair in our center. Patients were divided into three groups comprising isolated ascending aorta, proximal aortic arch, and distal aortic arch entry tear site and were followed up for up to 9 years...
June 13, 2018: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/29898143/predictors-of-outcomes-after-correction-of-acute-type-a-aortic-dissection-under-moderate-hypothermic-circulatory-arrest-and-antegrade-cerebral-perfusion
#8
George Samanidis, Charalampos Katselis, Constantinos Contrafouris, Georgios Georgiopoulos, Ioannis Kriaras, Theofani Antoniou, Konstantinos Perreas
INTRODUCTION: Hypothermic circulatory arrest is widely used for correction of acute type A aortic dissection pathology. We present our experience of 45 consecutive patients operated in our unit with bilateral antegrade cerebral perfusion and moderate hypothermic circulatory arrest. METHODS: Between January 2011 and April 2015, 45 consecutive patients were admitted for acute type A aortic dissection and operated emergently under moderate hypothermic circulatory arrest and bilateral antegrade cerebral perfusion...
March 2018: Brazilian Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29898139/effect-of-ischemic-postconditioning-and-atorvastatin-in-the-prevention-of-remote-lung-reperfusion-injury
#9
Carlos Henrique Marques Dos Santos, Doroty Mesquita Dourado, Baldomero Antonio Kato da Silva, Henrique Budib Dorsa Pontes, Euler de Azevedo Neto, Giovanna Serra da Cruz Vendas, Ian de Oliveira Chaves, João Victor Cunha Miranda, João Victor Durães Gomes Oliva, Letícia do Espírito Santo Dias, Murillo Henrique Martins de Almeida, Trícia Luna Sampaio
OBJECTIVE: The aim of the present study was to evaluate the ability of ischemic postconditioning, atorvastatin and both associated to prevent or minimize reperfusion injury in the lung of rats subjected to ischemia and reperfusion by abdominal aortic clamping. METHODS: We used 41 Wistar norvegic rats, which were distributed into 5 groups: ischemia and reperfusion (I/R), ischemic postcondictioning (IPC), postconditioning + atorvastatin (IPC+A), atorvastatin (A) and SHAM...
March 2018: Brazilian Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29896044/open-replacement-of-the-thoracoabdominal-aorta-short-and-long-term-outcomes-at-a-single-institution
#10
Davide Carino, Young Erben, Mohammad A Zafar, Mrinal Singh, Adam J Brownstein, Maryann Tranquilli, John Rizzo, Bulat A Ziganshin, John A Elefteriades
Background  Despite much progress in the surgical and endovascular treatment of thoracoabdominal aortic diseases (TAADs), there is no consensus regarding the optimal approach to minimize operative mortality and end-organ dysfunction. We report our experience in the past 16 years treating TAAD by open surgery. Methods  A retrospective review of all TAAD patients who underwent an open repair since January 2000 was performed. The primary endpoints included early morbidity and mortality, and the secondary endpoints were overall death and rate of aortic reintervention...
June 2018: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/29896041/redo-aortic-root-operations-in-patients-with-marfan-syndrome
#11
REVIEW
Vicente Orozco-Sevilla, Richard Whitlock, Ourania Preventza, Kim I de la Cruz, Joseph S Coselli
Aortic root aneurysm is the most common cardiovascular manifestation requiring surgical intervention in patients with Marfan syndrome (MFS), a heritable thoracic aortic disease. Elective replacement of the aortic root is the treatment of choice for patients with aneurysmal complications of the aortic root and ascending aorta. There are two basic approaches to aortic root replacement: valve-sparing (VS) and valve-replacing (VR) techniques. After successful aortic root replacement surgery, several patients with MFS may develop a late complication related to their aortic disease process, such as developing a pseudoaneurysm of the coronary artery reattachment buttons, aneurysmal expansion, or aortic dissection in the remaining native aorta...
June 2018: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/29896040/endovascular-treatment-of-various-aortic-pathologies-review-of-the-latest-data-and-technologies
#12
REVIEW
Koji Maeda, Takao Ohki, Yuji Kanaoka
The technologies and innovations applicable to endovascular treatment for complex aortic pathologies have progressed rapidly over the last two decades. Although the initial outcomes of an endovascular aortic repair have been excellent, as long-term data became available, complications including endoleaks, endograft migration, and endograft infection have become apparent and are of concern. Previously, the indication for endovascular therapy was restricted to descending thoracic aortic aneurysms and abdominal aortic aneurysms...
June 2018: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/29895380/the-sooner-the-better-early-strategies-of-peripheral-vascular-intervention-for-patients-with-acute-aortic-dissection-complicated-by-organ-malperfusion
#13
EDITORIAL
Yutaka Okita
No abstract text is available yet for this article.
April 12, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29893684/risk-factors-for-permanent-neurological-dysfunction-and-early-mortality-in-patients-with-type-a-aortic-dissection-requiring-total-arch-replacement
#14
Li Jiang, Sai Chen, Zhao Jian, Yingbin Xiao
Surgery is a definitive treatment for patients with type A aortic dissection. The aim of this study was to identify and analyze the risk factors for permanent neurological dysfunction (PND) and 30-day mortality in patients following total arch replacement and stented elephant trunk implantation in the descending aorta. Methods: The clinical data of 85 consecutive patients who underwent this surgical procedure between December 2013 and May 2017 were reviewed. Multivariate logistic regression analysis was performed to determine the independent predictors of postoperative PND and 30-day mortality...
May 30, 2018: Heart Surgery Forum
https://www.readbyqxmd.com/read/29893668/direct-cannulation-of-ascending-aorta-versus-standard-femoral-artery-cannulation-in-acute-aortic-dissection-type-a
#15
Vassil Gegouskov, Georgi Manchev, Vladimir Danov, Georgi Stoitsev, Sergey Iliev
BACKGROUND: During surgery for ascending aortic dissection, the dissected ascending aorta itself has traditionally been rejected as a cannulation option. The purpose of this study is to prove that direct cannulation of the ascending aorta in patients operated for acute aortic dissection type A (AADA) is at least as effective and safe as classic femoral cannulation. METHODS AND RESULTS: Between September 2008 and January 2015, we operated on 117 patients with AADA through median sternotomy...
April 30, 2018: Heart Surgery Forum
https://www.readbyqxmd.com/read/29893359/correlation-between-sex-and-prognosis-of-acute-aortic-dissection-in-the-chinese-population
#16
Yan-Jie Liu, Xiao-Zeng Wang, Ya Wang, Rui-Xia He, Lin Yang, Quan-Min Jing, Hai-Wei Liu
Background: The prevalence, presentation, management, and prognosis of coronary heart disease differ according to sex. Greater understanding on the differences between men and women with acute aortic dissection (AAD) is needed. We aimed to investigate whether sex disparities are found in patients with AAD, and to study sex differences in complications, mortality in-hospital, and long-term. Methods: We included 884 patients enrolled in our institute between June 2002 and May 2016...
June 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29891434/mid-term-outcomes-of-stent-assisted-balloon-induced-intimal-disruption-and-relamination-in-aortic-dissection-repair-stabilise-in-acute-type-b-aortic-dissection
#17
Elsa M Faure, Salma El Batti, Marwan Abou Rjeili, Pierre Julia, Jean-Marc Alsac
OBJECTIVES: This article reports mid-term results of 41 patients treated by the stent assisted balloon induced intimal disruption and relamination (STABILISE) technique for acute type B aortic dissection. METHODS: Between November 2011 and November 2017, 41 patients (10 male; median age 50 years) underwent proximal descending aortic stent grafting plus stent assisted balloon induced intimal disruption of the thoraco-abdominal aorta for acute type B aortic dissection...
June 8, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29890445/evidence-of-aortic-dissection-and-marfan-syndrome-in-a-mummy-from-the-capuchin-catacombs-of-palermo-sicily
#18
Stephanie Panzer, Randall C Thompson, Klaus Hergan, Albert R Zink, Dario Piombino-Mascali
The authors report on the assessment of an anthropogenic mummy of a young man from the Capuchin Catacombs of Palermo, Sicily, tentatively dated from the mid- to late 19th century AD. The mummy was investigated by full-body CT examination. CT images clearly showed aortic dissection classified as Stanford-A. Due to the relation of aortic dissection to inherited connective tissue diseases in young people, such as Marfan syndrome, conspicuous and pathological findings possibly indicating the presence of underlying Marfan syndrome were assessed...
June 8, 2018: International Journal of Paleopathology
https://www.readbyqxmd.com/read/29887830/a-novel-pkd1-mutation-associated-with-autosomal-dominant-kidney-disease-and-cerebral-cavernous-malformation
#19
Christian Thomas, Andrea Zühlsdorf, Konstanze Hörtnagel, Lejla Mulahasanovic, Oliver M Grauer, Philipp Kümpers, Heinz Wiendl, Sven G Meuth
Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder characterized by the presence of renal cysts and specific extrarenal abnormalities. ADPKD is caused by mutations in either PKD1 or PKD2 genes that encode for integral membrane proteins Polycystin-1 (PC1) and Polycystin-2 (PC2), respectively. Extrarenal involvement includes noncystic manifestations such as dilatation of the aortic root, artery dissection and intracranial aneurysms. Cerebral cavernous malformation (CCM) is a rare vascular malformation disorder characterized by closely clustered and irregularly dilated capillaries that can be asymptomatic or cause variable neurological manifestations, such as seizures, non-specific headaches, progressive or transient focal neurologic deficits, and cerebral hemorrhages...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29887702/the-futility-of-systematic-lymphadenectomy-in-early-stage-low-grade-endometrial-cancer
#20
Nidhi Nayyar, Prerna Lakhwani, Ashish Goel, Pankaj Kr Pande, Kapil Kumar
Lymphadenectomy is considered an integral part of comprehensive surgical staging of endometrial cancer but debate on the value of lymphadenectomy continues in early-stage endometrial cancer. The aim of our study was to determine the number of node positive patients in clinically early-stage low-grade (G1-G2) endometrioid endometrial cancer. We retro-prospectively analyzed the medical records of 155 women with endometrial pathology coming to the BLK cancer center between January 2015 and December 2017 and studied 60 patients of FIGO grade 1-2 endometrioid endometrial cancer confined to the uterus to determine the nodal positivity...
June 2018: Indian Journal of Surgical Oncology
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