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Cruz lemini

Mérida Rodríguez-López, Mónica Cruz-Lemini, Brenda Valenzuela-Alcaraz, Laura Garcia-Otero, Marta Sitges, Bart Bijnens, Eduard Gratacos, Fatima Crispi
OBJECTIVE: To identify the presence of different cardiac phenotypes among FGR. STUDY DESIGN: Fetal echocardiography was performed in 126 FGR (defined as birth weight <10(th) centile) and 64 adequate for gestational age (AGA). Principal component and cluster analyses were performed to identify different cardiac phenotypes among FGR cases. RESULTS: Three different cardiac phenotypes were identified within FGR: globular, elongated and hypertrophic...
November 18, 2016: Ultrasound in Obstetrics & Gynecology
Rui V Simões, Emma Muñoz-Moreno, Mónica Cruz-Lemini, Elisenda Eixarch, Núria Bargalló, Magdalena Sanz-Cortés, Eduard Gratacós
BACKGROUND: Intrauterine growth restriction and premature birth represent 2 independent problems that may occur simultaneously and contribute to impaired neurodevelopment. OBJECTIVE: The objective of the study was to assess changes in the frontal lobe metabolic profiles of 1 year old intrauterine growth restriction infants born prematurely and adequate-for-gestational-age controls, both premature and term adequate for gestational age and their association with brain structural and biophysical parameters and neurodevelopmental outcome at 2 years...
January 2017: American Journal of Obstetrics and Gynecology
R Cruz-Martinez, A Mendez, M Cruz-Lemini, M Martinez-Rodriguez, B Nieto-Castro, A K Gámez-Varela, C Rebolledo-Fernández
No abstract text is available yet for this article.
September 2016: Ultrasound in Obstetrics & Gynecology
M Rodriguez-Lopez, M Cruz-Lemini, B Valenzuela-Alcaraz, L Garcia-Otero, M Sitges, B Bijnens, E Gratacós, F Crispi
No abstract text is available yet for this article.
September 2016: Ultrasound in Obstetrics & Gynecology
Brenda Valenzuela-Alcaraz, Fátima Crispi, Mónica Cruz-Lemini, Bart Bijnens, Laura García-Otero, Marta Sitges, Joan Balasch, Eduard Gratacós
OBJECTIVE: Assisted reproductive technologies (ART) and small-for-gestational-age (SGA) fetuses show cardiovascular remodeling in utero; however, these conditions are often associated. We evaluated the differential effect of ART and SGA on fetal cardiac remodeling. METHODS: We performed a prospective cohort study including term singleton pregnancies, divided into four groups: 102 appropriate for gestational age (AGA) fetuses conceived spontaneously (controls), 72 AGA fetuses conceived by ART (ART-AGA), 31 SGA fetuses conceived by ART (ART-SGA) and 28 SGA fetuses conceived naturally (SGA)...
July 15, 2016: Ultrasound in Obstetrics & Gynecology
Eva Stein, Monica Cruz-Lemini, Jose Altamirano, Nambi Ndugga, David Couper, Juan G Abraldes, Ramon Bataller
BACKGROUND & AIMS: Studies assessing alcohol as a population-level risk factor for cirrhosis, typically focus on per capita consumption. However, clinical studies indicate that daily intake is a strong predictor of alcoholic cirrhosis. We aimed to identify the determinants of alcohol's contribution to the global cirrhosis burden and to evaluate the influence of daily drinking on a population level. METHODS: We performed a comprehensive analysis of the WHO 2014 Global Status Report on Alcohol and Health...
July 5, 2016: Journal of Hepatology
A Ruiz, M Cruz-Lemini, N Masoller, M Sanz-Cortés, Q Ferrer, I Ribera, J M Martínez, F Crispi, S Arévalo, O Gómez, S Pérez-Hoyos, E Carreras, E Gratacós, E Llurba
OBJECTIVES: To determine the longitudinal behaviour of fetal biometries and cerebroplacental haemodynamics thoughout gestation in fetuses with congenital heart disease (CHD). METHODS: Fetal biometries and Doppler haemodynamics (uterine artery (UtA), umbilical artery (UA) and middle cerebral artery (MCA)) were serially measured in a cohort of consecutive fetuses diagnosed with CHD. Evaluations were made at various time points, from diagnosis (<25 weeks) to delivery, with at least 2 measurements per foetus and at least 2 weeks apart...
May 23, 2016: Ultrasound in Obstetrics & Gynecology
Patricia Garcia-Canadilla, Fatima Crispi, Monica Cruz-Lemini, Brenda Valenzuela-Alcaraz, Paula A Rudenick, Eduard Gratacos, Bart H Bijnens
OBJECTIVE: The aortic isthmus (AoI) blood flow has a characteristic shape with a small end-systolic notch observed during the third trimester of pregnancy. However, what causes the appearance of this notch is not fully understood. We used a lumped model of the fetal circulation to study the possible factors causing the end-systolic notch and the changes of AoI flow through gestation. METHODS: A validation of the model was performed by fitting patient-specific data from two normal fetuses...
2017: Fetal Diagnosis and Therapy
Brenda Valenzuela-Alcaraz, Fátima Crispi, Dolors Manau, Mónica Cruz-Lemini, Aina Borras, Juan Balasch, Eduard Gratacós
Objectives To examine perinatal outcomes in pregnancies conceived by different methods: fertile women with spontaneous pregnancies, infertile women who achieved pregnancy without treatment, pregnancies achieved by ovulation induction (OI) and in vitro fertilization or intra-cytoplasmic sperm injection (IVF/ICSI). Methods Retrospective single-center cohort study including 200 fertile and 748 infertile women stratified according to infertility treatment. The outcome measurements were preterm delivery (PTD), small-for-gestational-age (SGA), gestational diabetes, placenta previa or preeclampsia...
December 2016: Journal of Maternal-fetal & Neonatal Medicine
Rogelio Cruz-Martínez, Monica Cruz-Lemini, Antonio Mendez, Miriam Illa, Víctor García-Baeza, Josep Maria Martinez, Eduard Gratacós
OBJECTIVE: To assess the learning curve for intrapulmonary artery Doppler in fetuses with congenital diaphragmatic hernia (CDH). METHODS: Three fetal medicine fellows with the theoretic knowledge, but without prior experience, in the evaluation of intrapulmonary artery Doppler in CDH fetuses were selected. Each trainee and 1 experienced explorer assessed the intrapulmonary artery in the contralateral lung to the side of the hernia for calculation of 2 Doppler parameters - pulsatility index (PI) and peak early diastolic reversed flow (PEDRF) - in a cohort of 90 consecutive CDH fetuses...
2016: Fetal Diagnosis and Therapy
Mónica Cruz-Lemini, Brenda Valenzuela-Alcaraz, Francesc Figueras, Marta Sitges, Olga Gómez, Josep María Martínez, Bart Bijnens, Eduard Gratacós, Fátima Crispi
INTRODUCTION: Recent studies have reported variations of up to 30% between different ultrasound machines for tissue Doppler imaging (TDI), a problem that can significantly impact clinical diagnosis, patient management and research studies. The objective of this study was to assess repeatability and agreement between fetal myocardial peak velocities evaluated by TDI with two different ultrasound systems. MATERIALS AND METHODS: Systolic (S'), early (E') and late (A') diastolic myocardial peak velocities at mitral and tricuspid annuli as well as at the basal septum were evaluated by spectral TDI in 150 fetuses using two different ultrasound systems: Siemens Antares (Siemens Medical Systems, Malvern, Pa...
2016: Fetal Diagnosis and Therapy
M Cruz-Lemini, F Crispi, B Valenzuela-Alcaraz, F Figueras, M Sitges, B Bijnens, E Gratacós
OBJECTIVES: Intrauterine growth restriction is associated with increased cardiovascular risk later in life but the link between fetal disease and postnatal risk is not well-documented. We evaluated longitudinally the association between cardiovascular remodeling in small-for-gestational-age (SGA) fetuses and at 6 months of age. METHODS: A cohort of 80 SGA fetuses (defined by estimated fetal and birth weights < 10(th) centile) delivered > 34 weeks' gestation was compared with 80 normally grown age-matched control fetuses, with follow-up at 6 months of corrected age (i...
September 2016: Ultrasound in Obstetrics & Gynecology
Merida Rodriguez-Lopez, Lyda Osorio, Ruthy Acosta-Rojas, Josep Figueras, Monica Cruz-Lemini, Francesc Figueras, Bart Bijnens, Eduard Gratacós, Fatima Crispi
BACKGROUND: Our aim was to determine the influence of breastfeeding and postnatal nutrition on cardiovascular remodeling induced by fetal growth restriction (FGR). METHODS: A cohort study including 81 children with birthweight <10th centile (FGR) and 121 with adequate fetal growth for gestational age (AGA) was conducted. Cardiovascular endpoints were left ventricular sphericity index (LVSI), carotid intima-media thickness (cIMT), and blood pressure (BP) at 4-5 y of age...
January 2016: Pediatric Research
Javier U Ortiz, Fatima Crispi, Ryo Yamamoto, Narcis Masoller, Monica Cruz-Lemini, Olga Gómez, Mar Bennasar, Silvia M Lobmaier, Elisenda Eixarch, Josep M Martinez, Eduard Gratacós
OBJECTIVE: To evaluate mitral and tricuspid annular plane systolic excursion (MAPSE and TAPSE) in fetuses with twin-to-twin transfusion syndrome (TTTS) before and after laser therapy. METHODS: A prospective study in 24 fetal pairs with TTTS evaluated 24 h before and within 48 h after fetoscopy and 13 gestational age-matched normal monochorionic fetal pairs. MAPSE and TAPSE were measured in an apical or basal four-chamber view by placing the M-mode cursor at the lateral valve ring...
December 2015: Prenatal Diagnosis
Patricia Garcia-Canadilla, Fatima Crispi, Monica Cruz-Lemini, Stefania Triunfo, Alfons Nadal, Brenda Valenzuela-Alcaraz, Paula A Rudenick, Eduard Gratacos, Bart H Bijnens
INTRODUCTION: Intrauterine growth restriction (IUGR) due to placental insufficiency is associated with blood-flow redistribution in order to maintain perfusion to the brain. However, some hemodynamic parameters that might be more directly related to staging of the disease cannot be measured non-invasively in clinical practice. For this, we developed a patient-specific model of the fetal circulation to estimate vascular properties of each individual. METHODS: A lumped model of the fetal circulation was developed and personalized using measured echographic data from 37 normal and IUGR fetuses to automatically estimate model-based parameters...
September 2015: Placenta
C Lemini, E García-Albor, B Cruz-López, G Matamoros-Trejo, L Martínez-Mota
Estrogens of clinical use produce consistent antidepressant- and anxiolytic-like effects in animal models of menopause. Regulation of the hypothalamic-pituitary-adrenal (HPA) or stress axis, has been proposed as a pathway through which estrogens improve affective-like behaviors. Anticoagulant 17β-aminoestrogens (17β-AEs) butolame and pentolame mimic some effects of estradiol (E2), i.e., on female rodent sexual behavior, with opposite actions on coagulation. However, their psychoactive actions have not been explored...
January 4, 2016: Progress in Neuro-psychopharmacology & Biological Psychiatry
Carlos Landa-Solís, Julio Granados-Montiel, Anell Olivos-Meza, Carmina Ortega-Sánchez, Mónica Cruz-Lemini, Cecilia Hernández-Flores, María Eugenia Chang-González, Ricardo Gómez García, Brenda Olivos-Díaz, María Cristina Velasquillo-Martínez, Carlos Pineda, Clemente Ibarra
Mobilized peripheral blood (MPB) bone marrow cells possess the potential to differentiate into a variety of mesenchymal tissue types and offer a source of easy access for obtaining stem cells for the development of experimental models with applications in tissue engineering. In the present work, we aimed to isolate by magnetic activated cell sorting CD90+ cells from MPB by means of the administration of Granulocyte-Colony Stimulating Factor and to evaluate cell proliferation capacity, after thawing of the in vitro culture of this population of mesenchymal stem cells (MSCs) in sheep...
March 2016: Cell and Tissue Banking
M Pérez-Cruz, M Cruz-Lemini, M T Fernández, J A Parra, J Bartrons, M D Gómez-Roig, F Crispi, E Gratacós
OBJECTIVE: Among late-onset small fetuses, a combination of estimated fetal weight (EFW), cerebroplacental ratio (CPR) and mean uterine artery (UtA) pulsatility index (PI) can predict a subgroup of fetuses with poor perinatal outcome; however, the association of these criteria with fetal cardiac structure and function is unknown. Our aim was to determine the presence and severity of signs indicating cardiac dysfunction in small fetuses, classified as intrauterine growth-restricted (IUGR) or small-for-gestational age (SGA), according to EFW, CPR and UtA-PI...
October 2015: Ultrasound in Obstetrics & Gynecology
Rui V Simões, Mónica Cruz-Lemini, Núria Bargalló, Eduard Gratacós, Magdalena Sanz-Cortés
OBJECTIVE: We assessed brain metabolite levels by magnetic resonance spectroscopy (MRS) in 1-year-old infants born small at term, as compared with infants born appropriate for gestational age (AGA), and their association with neurodevelopment at 2 years of age. STUDY DESIGN: A total of 40 infants born small (birthweight <10th centile for gestational age) and 30 AGA infants underwent brain MRS at age 1 year on a 3-T scanner. Small-born infants were subclassified as late intrauterine growth restriction or as small for gestational age, based on the presence or absence of prenatal Doppler and birthweight predictors of an adverse perinatal outcome, respectively...
August 2015: American Journal of Obstetrics and Gynecology
I Stergiotou, B Bijnens, M Cruz-Lemini, F Figueras, E Gratacos, F Crispi
OBJECTIVE: To assess maternal vascular structure and function in pregnancies complicated by fetal growth restriction (FGR), in women with and without pre-eclampsia (PE) at the time of FGR diagnosis. METHODS: We evaluated 124 women with a pregnancy complicated by FGR, of whom 60 had PE and 64 did not, and compared these findings to those of 110 normal women (controls). The group of FGR pregnancies without PE was further subdivided according to gestational age at FGR diagnosis into early onset (< 32 weeks) or late onset (≥ 32 weeks)...
December 2015: Ultrasound in Obstetrics & Gynecology
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