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https://www.readbyqxmd.com/read/29590631/comprehensive-molecular-profiling-identifies-foxm1-as-a-key-transcription-factor-for-meningioma-proliferation
#1
Harish N Vasudevan, Steve E Braunstein, Joanna J Phillips, Melike Pekmezci, Bryan A Tomlin, Ashley Wu, Gerald F Reis, Stephen T Magill, Jie Zhang, Felix Y Feng, Theodore Nicholaides, Susan M Chang, Penny K Sneed, Michael W McDermott, Mitchel S Berger, Arie Perry, David R Raleigh
Meningioma is the most common primary intracranial tumor, but the molecular drivers of aggressive meningioma are incompletely understood. Using 280 human meningioma samples and RNA sequencing, immunohistochemistry, whole-exome sequencing, DNA methylation arrays, and targeted gene expression profiling, we comprehensively define the molecular profile of aggressive meningioma. Transcriptomic analyses identify FOXM1 as a key transcription factor for meningioma proliferation and a marker of poor clinical outcomes...
March 27, 2018: Cell Reports
https://www.readbyqxmd.com/read/29143321/interobserver-agreement-on-standardized-ultrasound-and-histopathologic-signs-for-the-prenatal-diagnosis-of-placenta-accreta-spectrum-disorders
#2
Nurit Zosmer, Eric Jauniaux, Catey Bunce, Jenie Panaiotova, Hizbullah Shaikh, Kypros H Nicholaides
OBJECTIVE: To evaluate interobserver agreement in assessment of ultrasound signs and histopathologic findings associated with placenta accreta spectrum (PAS) disorders. METHODS: A retrospective study was conducted using data for patients prenatally diagnosed with PAS disorders at a UK hospital between January 31, 2012, and March 30, 2017. Ultrasound images (including gray-scale and color Doppler imaging [CDI] parameters) and histopathologic slides were reviewed by two observers; the level of agreement was calculated...
March 2018: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29040209/inherited-and-acquired-clinical-phenotypes-associated-with-neuroendocrine-tumors
#3
Rory E Nicolaides, M Teresa de la Morena
PURPOSE OF REVIEW: Overview of neuroendocrine neoplasms in the context of their associations with primary and secondary immunodeficiency states. RECENT FINDINGS: Malignancies of neuroendocrine origin are well known to be associated with hereditary syndromes, including multiple endocrine neoplasia type 1, von Hippel-Lindau syndrome, neurofibromatosis type 1, and tuberous sclerosis. This review includes the X-linked form of hyper-IgM syndrome (XHIGM), due to mutations in the CD40Ligand gene (CD40LG), as an additional inherited disorder with susceptibility to such malignancies, and discusses neuroendocrine tumors (NETs) arising in other immunocompromised states...
December 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/19796731/prevention-of-preterm-birth-based-on-short-cervix-progesterone
#4
REVIEW
Eduardo B da Fonseca, Rievani DamiĆ£o, Kypros Nicholaides
Preterm delivery, which occurs in about 5%-13% of pregnancies in most countries, is the main cause of neonatal morbidity and mortality. Symptomatic treatment of pregnancies presenting in preterm labor with corticosteroids has improved perinatal outcome but has not reduced the incidence of preterm delivery. Recent evidence suggests that the rate of preterm delivery may be reduced by the prophylactic use of progesterone in women with a history of preterm delivery and in those with a short cervical length identified by routine transvaginal sonography...
October 2009: Seminars in Perinatology
https://www.readbyqxmd.com/read/17819134/amazon-basin-soils-management-for-continuous-crop-production
#5
P A Sanchez, D E Bandy, J H Villachica, J J Nicholaides
Technology has been developed which permits continuous production of annual crops in some of the acid, infertile soils of the Amazon Basin. Studies in Yurimaguas, Peru, show that three grain crops can be produced annually with appropriate fertilizer inputs. Twenty-one crops have been harvested during the past 8(1/2) years in the same field, with an average annual production of 7.8 tons of grain per hectare. Soil properties are improving with continuous cultivation. The technology has been validated by local farmers, who normally practice shifting cultivation...
May 21, 1982: Science
https://www.readbyqxmd.com/read/13368460/adrenocortical-tumour-with-hypokalaemia-and-flaccid-muscle-paralysis
#6
C H CAMPBELL, N NICHOLAIDES, A W STEINBECK
No abstract text is available yet for this article.
September 15, 1956: Lancet
https://www.readbyqxmd.com/read/8088114/serum-lipids-and-apolipoproteins-and-their-relationship-with-macrovascular-disease-in-type-1-diabetes
#7
COMPARATIVE STUDY
P K Merrin, S Renton, C Fisher, A Henderson, W Richmond, A Nicholaides, R S Elkeles
In order to examine the relationship between serum lipids and apolipoproteins and macrovascular disease in patients with Type 1 diabetes mellitus, 50 patients with Type 1 diabetes mellitus attending the diabetic clinics at St Mary's and St Charles' Hospitals, London were recruited into a cross-sectional study. B-mode ultrasound was used to measure intima-media thickness and define an arterial ultrasound score for each patient as a non-invasive indicator of atherosclerotic change. Intima-medial (i-m) thickness was significantly higher in those subjects with clinical evidence of macrovascular disease compared to those without macrovascular disease (0...
May 1994: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/7767004/genetic-mapping-of-bola-a-cyp21-drb3-dya-and-prl-on-bta23
#8
COMPARATIVE STUDY
M J van Eijk, J E Beever, Y Da, J A Stewart, G E Nicholaides, C A Green, H A Lewin
No abstract text is available yet for this article.
February 1995: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/5766855/the-dienoic-fatty-acids-of-human-skin-surface-lipid
#9
N Nicholaides, M N Ansari
No abstract text is available yet for this article.
January 1969: Lipids
https://www.readbyqxmd.com/read/2757261/microvascular-evaluation-of-the-effects-of-nifedipine-in-vascular-patients-by-laser-doppler-flowmetry
#10
G Belcaro, A N Nicholaides
Skin blood flow in the microcirculation of the distal foot was evaluated in patients with vascular disease and diabetes and compared with that in normal volunteers by use of laser-Doppler flowmetry. Resting flow (RF) and the flow on standing (SF) were measured in a room at constant temperature (20-22 degrees C). RF was significantly different in the five groups, being increased in patients with diabetes (in comparison with normal volunteers) and decreased in patients with intermittent claudication, rest pain, and ischemic limbs...
August 1989: Angiology
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