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https://www.readbyqxmd.com/read/28332335/second-to-third-trimester-longitudinal-growth-assessment-for-the-prediction-of-sga-and-late-fgr
#1
J Caradeux, E Eixarch, E Mazarico, T R Basuki, E Gratacos, F Figueras
BACKGROUND: Detection of fetal growth restriction (FGR) remains poor. Most screening strategies rely on a cross-sectional evaluation of fetal size at one point during the third trimester. A longitudinal and individualized approach may allow a more appropriate evaluation. OBJECTIVES: To compare second to third trimester longitudinal growth assessment with cross-sectional evaluation at third trimester in the prediction of SGA and late FGR. METHODS: A cohort of 2696 unselected singletons pregnancies scanned at 21 ± 2 and 32 ± 2 weeks was created...
March 23, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28329054/whole-heart-detailed-and-quantitative-anatomy-myofibre-structure-and-vasculature-from-x-ray-phase-contrast-synchrotron-radiation-based-micro-computed-tomography
#2
Anna Gonzalez-Tendero, Chong Zhang, Vedrana Balicevic, Rubén Cárdenes, Sven Loncaric, Constantine Butakoff, Bruno Paun, Anne Bonnin, Patricia Garcia-Cañadilla, Emma Muñoz-Moreno, Eduard Gratacós, Fatima Crispi, Bart Bijnens
Background: While individual cardiac myocytes only have a limited ability to shorten, the heart efficiently pumps a large volume-fraction thanks to a cell organization in a complex 3D fibre structure. Subclinical subtle cardiac structural remodelling is often present before symptoms arise. Understanding and early detection of these subtle changes is crucial for diagnosis and prevention. Additionally, personalized computational modelling requires knowledge on the multi-scale structure of the whole heart and vessels...
March 15, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28295792/biventricular-impact-of-mild-to-moderate-pulmonary-valve-stenosis-in-fetal-life
#3
L Guirado, F Crispi, N Masoller, M Bennasar, E Marimon, J Carretero, E Gratacós, J M Martínez, M K Friedberg, O Gómez
OBJECTIVES: to define the pattern of fetal echocardiographic changes associated with isolated pulmonary valve stenosis (PS) and to correlate the echocardiographic findings with the neonatal outcome and the need of postnatal pulmonary valvuloplasty within the first 12 months of life. METHODS: a prospective cohort study was designed on 16 fetuses with isolated PS and 48 controls matched by gestational age at scan (+/- 2 weeks). Fetal standard ultrasound and comprehensive echocardiography, which included cardiovascular morphometric parameters, systolic and diastolic functional and timing-measurements, were performed in all cases...
March 10, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28284772/development-of-a-checklist-for-patients-with-axial-spondyloarthritis-and-psoriatic-arthritis-in-daily-practice-only-tools-project
#4
Raquel Almodovar, Juan C Torre Alonso, Enrique Batlle, Concepción Castillo, Eduardo Collantes-Estevez, Eugenio de Miguel, Senén González, Jordi Gratacós, Azucena Hernández, Xavier Juanola, Luis F Linares, Manuel J Moreno, Mireia Moreno, Victoria Navarro-Compán, Carlos Rodríguez Lozano, Jesus Sanz, Agustí Sellas, Estíbaliz Loza, Pedro Zarco
OBJECTIVE: To standardize clinical evaluation of patients with axial spondyloarthritis (SpA) and psoriatic arthritis (PsA) using a checklist. METHODS: Qualitative study that included: 1) nominal group (18 experts); 2) literature reviews of measures used in the assessment of patients with axial SpA or PsA; and 3) focus groups, one with rheumatologists and another with patients, organized to become familiar with their opinion on medical assistance. Taking this into account, the experts selected the measures to be included in the checklist based on their relevance, feasibility, and the outcome type...
March 8, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28267443/balloon-removal-after-fetoscopic-endoluminal-tracheal-occlusion-for-congenital-diaphragmatic-hernia
#5
Julio A Jiménez, Elisenda Eixarch, Philip Dekoninck, João R Bennini, Roland Devlieger, Cleisson F Peralta, Eduard Gratacos, Jan Deprest
BACKGROUND: Isolated congenital diaphragmatic hernia (CDH) defect allows viscera to herniate into the chest, competing for space with the developing lungs. At birth, pulmonary hypoplasia leads to respiratory insufficiency and persistent pulmonary hypertension that is lethal in up to 30% of patients. Antenatal measurement of lung size and liver herniation can predict survival after birth. Prenatal intervention aims at stimulating lung development, clinically achieved by percutaneous fetal endoscopic tracheal occlusion (FETO) under local anesthesia...
March 3, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28252205/oxidative-damage-and-nitric-oxide-synthase-induction-by-surgical-uteroplacental-circulation-restriction-in-the-rabbit-fetal-heart
#6
Horacio Figueroa, Cristobal Alvarado, Jorge Cifuentes, Mauricio Lozano, Jocelyn Rocco, Claudia Cabezas, Sebastian Illanes, Elisenda Eixarch, Edgar Hernández-Andrade, Eduard Gratacós, Carlos E Irarrazabal
OBJECTIVE: This study investigated the role of oxidative damage and nitric oxide (NO) synthases in the fetal heart using a model of intrauterine growth restriction (IUGR) induced by uteroplacental circulation restriction (UCR). METHODS: New Zealand white rabbits kept under 12 hr light cycles, with food and water provided ad libitum, were subjected at day 25 of pregnancy to 40%-50% uteroplacental artery ligation. We analyzed the gene expression of enzymes linked to nitric oxide synthesis (iNOS, eNOS, HO-1, and ARG-2), HIF-1α and the state of oxidative stress (protein carbonyl levels) in fetal heart homogenates...
March 2, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/28249267/smoking-induced-changes-in-the-maternal-immune-endocrine-and-metabolic-pathways-and-their-impact-on-fetal-growth-a-topical-review
#7
Sally Sabra, Eduard Gratacós, Maria Dolores Gómez Roig
Perinatal maternal smoking exposure (PMSE) is one of the major environmental risk factors encountered by the fetus. PMSE is usually associated with adverse pregnancy outcomes that may manifest at different stages of life. Nevertheless, fetal growth restriction is the most common smoking-induced side effect. PMSE induces changes in the maternal multiple organ systems. These alterations may affect placentation, which subsequently affects fetal growth. It is worthy to note, however, that the extent of maternal smoking-induced changes depends mainly on the maternal level of susceptibility...
March 2, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28169498/re-validation-of-a-first-trimester-screening-model-for-pre-eclampsia-in-an-unselected-population-e-scazzocchio-f-crovetto-s-triunfo-e-gratac%C3%A3-s-and-f-figueras-ultrasound-obstet-gynecol-2017-49-188-193
#8
COMMENT
https://www.readbyqxmd.com/read/28114884/everrest-prospective-study-a-6-year-prospective-study-to-define-the-clinical-and-biological-characteristics-of-pregnancies-affected-by-severe-early-onset-fetal-growth-restriction
#9
Rebecca Spencer, Gareth Ambler, Jana Brodszki, Anke Diemert, Francesc Figueras, Eduard Gratacós, Stefan R Hansson, Kurt Hecher, Angela Huertas-Ceballos, Neil Marlow, Karel Marsál, Eva Morsing, Donald Peebles, Carlo Rossi, Neil J Sebire, John F Timms, Anna L David
BACKGROUND: Fetal growth restriction (FGR) is a serious obstetric condition for which there is currently no treatment. The EVERREST Prospective Study has been designed to characterise the natural history of pregnancies affected by severe early onset FGR and establish a well phenotyped bio-bank. The findings will provide up-to-date information for clinicians and patients and inform the design and conduct of the EVERREST Clinical Trial: a phase I/IIa trial to assess the safety and efficacy of maternal vascular endothelial growth factor (VEGF) gene therapy in severe early onset FGR...
January 23, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28107492/correction-systemic-and-local-inflammatory-response-in-women-with-preterm-prelabor-rupture-of-membranes
#10
Teresa Cobo, Bo Jacobsson, Marian Kacerovsky, David M Hougaard, Kristin Skogstrand, Eduard Gratacós, Montse Palacio
[This corrects the article DOI: 10.1371/journal.pone.0085277.].
2017: PloS One
https://www.readbyqxmd.com/read/28094842/impact-of-microbial-invasion-of-amniotic-cavity-and-the-type-of-microorganisms-on-short-term-neonatal-outcome-in-women-with-preterm-labor-and-intact-membranes
#11
Teresa Cobo, Irene Vives, Adriano Rodríguez-Trujillo, Clara Murillo, Martina A Ángeles, Jordi Bosch, Andrea Vergara, Eduard Gratacós, Montse Palacio
INTRODUCTION: The objective was to evaluate the impact of microbial invasion of the amniotic cavity (MIAC) and the type of microorganisms on pregnancy and short-term neonatal outcomes in women with preterm labor (PTL). MATERIAL AND METHODS: Prospective observational cohort study including women with PTL from 22.0-36.0 weeks. MIAC was defined based on amniotic fluid aerobic/anaerobic/mycoplasmas cultures and intra-amniotic inflammation (IAI) based on amniotic fluid Interleukin-6 levels...
January 17, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28093413/persistence-of-cardiac-remodeling-in-preadolescents-with-fetal-growth-restriction
#12
Sebastian Imre Sarvari, Merida Rodriguez-Lopez, Marta Nuñez-Garcia, Marta Sitges, Alvaro Sepulveda-Martinez, Oscar Camara, Constantine Butakoff, Eduard Gratacos, Bart Bijnens, Fatima Crispi
BACKGROUND: Fetal growth restriction (FGR) affects 5% to 10% of newborns and is associated with increased cardiovascular mortality in adulthood. We evaluated whether prenatal cardiovascular changes previously demonstrated in FGR persist into preadolescence. METHODS AND RESULTS: A cohort study of 58 FGR (defined as birth weight below 10th centile) and 94 normally grown fetuses identified in utero and followed-up into preadolescence (8-12 years of age) by echocardiography and 3-dimensional shape computational analysis...
January 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28052270/neurodevelopmental-effects-of-undernutrition-and-placental-underperfusion-in-fetal-growth-restriction-rabbit-models
#13
Míriam Illa, Elisenda Eixarch, Emma Muñoz-Moreno, Dafnis Batalle, Rocío Leal-Campanario, Agnès Gruart, José María Delgado-García, Francesc Figueras, Eduard Gratacós
INTRODUCTION: Chronic reduction of oxygen and nutrient delivery to the fetus has been related to neurodevelopmental problems. Placental underperfusion induces a significant reduction in oxygen and nutrient delivery, whereas maternal undernutrition causes mainly nutrient deficiency. A comparison of the neurodevelopmental effects of both situations in pregnant rabbits was performed. MATERIALS AND METHODS: The placental underperfusion model was induced after uteroplacental vessel ligation at 25 days of pregnancy...
January 5, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28008304/structural-brain-network-reorganization-and-social-cognition-related-to-adverse-perinatal-condition-from-infancy-to-early-adolescence
#14
Emma Muñoz-Moreno, Elda Fischi-Gomez, Dafnis Batalle, Cristina Borradori-Tolsa, Elisenda Eixarch, Jean-Philippe Thiran, Eduard Gratacós, Petra S Hüppi
Adverse conditions during fetal life have been associated to both structural and functional changes in neurodevelopment from the neonatal period to adolescence. In this study, connectomics was used to assess the evolution of brain networks from infancy to early adolescence. Brain network reorganization over time in subjects who had suffered adverse perinatal conditions is characterized and related to neurodevelopment and cognition. Three cohorts of prematurely born infants and children (between 28 and 35 weeks of gestational age), including individuals with a birth weight appropriated for gestational age and with intrauterine growth restriction (IUGR), were evaluated at 1, 6, and 10 years of age, respectively...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28004439/prediction-of-fetal-growth-restriction-using-estimated-fetal-weight-versus-a-combined-screening-model-at-32-36-weeks-of-gestation
#15
Jezid Miranda, Merida Rodriguez-Lopez, Stefania Triunfo, Mikko Sairanen, Heikki Kouru, Miguel Parra-Saavedra, Francesca Crovetto, Francesc Figueras, Fatima Crispi, Eduard Gratacos
OBJECTIVES: To compare the performance of a third trimester screening based on estimated fetal weight (EFW) versus a combined model composed by maternal baseline characteristics, mean arterial pressure (MAP), ultrasound and biochemical markers for the prediction of smallness for gestational age (SGA) and late-onset fetal growth restriction (FGR). METHODS: Nested case-control study within a prospective cohort of 1,590 singleton gestations referred for third-trimester evaluation (32-36 weeks of gestation)...
December 22, 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27940123/an-integrated-approach-to-fetal-growth-restriction
#16
REVIEW
Francesc Figueras, Eduard Gratacos
Fetal growth restriction (FGR) is among the most common complications of pregnancy. FGR is associated with placental insufficiency and poor perinatal outcomes. Clinical management is challenging because of variability in clinical presentation. Fetal smallness (estimated fetal weight <10th centile for gestational age) remains the best clinical surrogate for FGR. However, it is commonly accepted that not all forms of fetal smallness represent true FGR. In a significant subset of small fetuses, there is no evidence of placental involvement, perinatal outcomes are nearly normal, and they are clinically referred to as "only" small for gestational age (SGA)...
January 2017: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/27936993/validation-of-the-prediction-model-for-success-of-vaginal-birth-after-cesarean-delivery-at-the-university-hospital-in-barcelona
#17
Anton Baranov, Eduard Gratacós, Olga Vikhareva, Francesc Figueras
OBJECTIVE: To validate the prediction model for successful vaginal birth after cesarean delivery (VBAC) based on variables easily obtainable at the first antenatal visit, in a Spanish population. METHODS: Retrospective observational study. Women with a single live fetus in cephalic presentation with one previous low-transverse CD who underwent trial of labor after cesarean delivery (TOLAC) at ≥37 gestational weeks between January 2011 and December 2015 were identified in the hospital's information system...
January 4, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27859818/descriptive-analysis-of-the-different-phenotypes-of-cardiac-remodeling-in-fetal-growth-restriction
#18
Mérida Rodríguez-López, Mónica Cruz-Lemini, Brenda Valenzuela-Alcaraz, Laura Garcia-Otero, Marta Sitges, Bart Bijnens, Eduard Gratacos, Fatima Crispi
OBJECTIVE: To identify the presence of different cardiac phenotypes among FGR. STUDY DESIGN: Fetal echocardiography was performed in 126 FGR (defined as birth weight <10(th) centile) and 64 adequate for gestational age (AGA). Principal component and cluster analyses were performed to identify different cardiac phenotypes among FGR cases. RESULTS: Three different cardiac phenotypes were identified within FGR: globular, elongated and hypertrophic...
November 18, 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27807890/impact-of-aspirin-on-trophoblastic-invasion-in-women-with-abnormal-uterine-artery-doppler-at-11%C3%A2-%C3%A2-14-weeks-a-randomized-controlled-study-asap
#19
Elena Scazzocchio, Dani Oros, Daysi Diaz, Juan C Ramirez, Marta Ricart, Eva Meler, Rafael González de Agüero, Eduard Gratacos, Francesc Figueras
BACKGROUND: Defective trophoblastic invasion is a key feature in many of cases of preeclampsia. Uterine artery Doppler is a validated non-invasive surrogate of this trophoblastic invasion. OBJECTIVE: To explore whether low-dose aspirin administered from the first trimester improves trophoblastic invasion, evaluated by uterine Doppler, during the second and third trimesters in women defined as high-risk by abnormal uterine artery Doppler at first trimester. METHODS: This randomized Phase II study had a triple-blind, parallel-arm, controlled design...
November 3, 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27801709/bedside-ultrasound-for-the-diagnosis-of-abnormal-diaphragmatic-motion-in-children-after-heart-surgery
#20
Laura Gil-Juanmiquel, Margarida Gratacós, Yolanda Castilla-Fernández, Joaquim Piqueras, Tracy Baust, Nuria Raguer, Joan Balcells, Santiago Perez-Hoyos, Raul F Abella, Joan Sanchez-de-Toledo
OBJECTIVE: To assess the utility of bedside ultrasound combining B- and M-mode in the diagnosis of abnormal diaphragmatic motion in children after heart surgery. DESIGN: Prospective post hoc blinded comparison of ultrasound performed by two different intensivists and fluoroscopy results with electromyography. SETTING: Tertiary university hospital. SUBJECTS: Children with suspected abnormal diaphragmatic motion after heart surgery...
February 2017: Pediatric Critical Care Medicine
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