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https://www.readbyqxmd.com/read/29082789/influence-of-perinatal-inflammation-on-the-neurodevelopmental-outcome-of-premature-infants
#1
Adriano Rodríguez-Trujillo, José Ríos, Martina A Ángeles, David E Posadas, Clara Murillo, Claudia Rueda, Francesc Botet, Jordi Bosch, Andrea Vergara, Eduard Gratacós, Montse Palacio, Teresa Cobo
OBJECTIVE: To evaluate the influence of perinatal inflammation on neurodevelopmental outcome of premature infants. STUDY DESIGN: From a retrospective cohort study of women with preterm labor with intact membranes or preterm prelabor rupture of membranes with an amniocentesis to rule out intra-amniotic inflammation (IAI) and microbial invasion of the amniotic cavity (MIAC), we evaluated neurodevelopmental outcome of their infants born between 24.0 and 34.0 weeks' gestation...
October 29, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29071119/switching-biological-disease-modifying-antirheumatic-drugs-in-patients-with-axial-spondyloarthritis-results-from-a-systematic-literature-review
#2
Victoria Navarro-Compán, Chamaida Plasencia-Rodríguez, Eugenio de Miguel, Petra Diaz Del Campo, Alejandro Balsa, Jordi Gratacós
OBJECTIVES: First, to investigate if switching biological disease-modifying antirheumatic drugs (bDMARDs) after the failure to prior bDMARD is efficacious in patients with axial spondyloarthritis (axSpA). Second, to evaluate the influence on this efficacy of (1) the reason to discontinue prior tumour necrosis factor inhibitor (TNFi), (2) changing the type of TNFi and (3) changing the target. METHODS: A systematic literature review until January 2017 was performed using Medline, EMBASE and Cochrane databases...
2017: RMD Open
https://www.readbyqxmd.com/read/29050839/recommendations-by-the-spanish-society-of-rheumatology-on-the-use-of-biological-therapies-in-axial-spondyloarthritis
#3
Jordi Gratacós, Petra Díaz Del Campo Fontecha, Cristina Fernández-Carballido, Xavier Juanola Roura, Luis Francisco Linares Ferrando, Eugenio de Miguel Mendieta, Santiago Muñoz Fernández, Jose Luis Rosales-Alexander, Pedro Zarco Montejo, Mercedes Guerra Rodríguez, Victoria Navarro Compán
OBJECTIVE: Recent data published on biological therapy in axial spondyloarthritis (axSpA) since the last publication of the recommendations of the Spanish Society of Rheumatology (SER) has led to the generation of a review of these recommendations based on the best possible evidence. These recommendations should be a reference for rheumatologists and those involved in the treatment of patients with axSpA. METHODS: Recommendations were drawn up following a nominal group methodology and based on systematic reviews...
October 16, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/29020672/early-environmental-enrichment-enhances-abnormal-brain-connectivity-in-a-rabbit-model-of-intrauterine-growth-restriction
#4
Miriam Illa, Verónica Brito, Laura Pla, Elisenda Eixarch, Ariadna Arbat-Plana, Dafnis Batallé, Emma Muñoz-Moreno, Fatima Crispi, Esther Udina, Francesc Figueras, Silvia Ginés, Eduard Gratacós
INTRODUCTION: The structural correspondence of neurodevelopmental impairments related to intrauterine growth restriction (IUGR) that persists later in life remains elusive. Moreover, early postnatal stimulation strategies have been proposed to mitigate these effects. Long-term brain connectivity abnormalities in an IUGR rabbit model and the effects of early postnatal environmental enrichment (EE) were explored. MATERIALS AND METHODS: IUGR was surgically induced in one horn, whereas the contralateral one produced the controls...
October 12, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28985223/heavy-metals-exposure-levels-and-their-correlation-with-different-clinical-forms-of-fetal-growth-restriction
#5
Sally Sabra, Ebba Malmqvist, Alicia Saborit, Eduard Gratacós, Maria Dolores Gomez Roig
BACKGROUND: Prenatal heavy metals exposure has shown a negative impact on birth weight. However, their influence on different clinical forms of fetal smallness was never assessed. OBJECTIVES: To investigate whether there is a differential association between heavy metals exposure and fetal smallness subclassification into intrauterine growth restriction (IUGR) and small-for-gestational age (SGA). METHOD: In this prospective case-control study, we included 178 mother-infant pairs; 96 of appropriate for gestational age (AGA) and 82 of small fetuses diagnosed in third trimester...
2017: PloS One
https://www.readbyqxmd.com/read/28982122/genetic-variation-associated-with-cardiovascular-risk-in-autoimmune-diseases
#6
Pedro P Perrotti, Adrià Aterido, Antonio Fernández-Nebro, Juan D Cañete, Carlos Ferrándiz, Jesús Tornero, Javier P Gisbert, Eugeni Domènech, Benjamín Fernández-Gutiérrez, Fernando Gomollón, Esther García-Planella, Emilia Fernández, Raimon Sanmartí, Jordi Gratacós, Víctor Manuel Martínez-Taboada, Luís Rodríguez-Rodríguez, Núria Palau, Raül Tortosa, Mireia L Corbeto, María L Lasanta, Sara Marsal, Antonio Julià
Autoimmune diseases have a higher prevalence of cardiovascular events compared to the general population. The objective of this study was to investigate the genetic basis of cardiovascular disease (CVD) risk in autoimmunity. We analyzed genome-wide genotyping data from 6,485 patients from six autoimmune diseases that are associated with a high socio-economic impact. First, for each disease, we tested the association of established CVD risk loci. Second, we analyzed the association of autoimmune disease susceptibility loci with CVD...
2017: PloS One
https://www.readbyqxmd.com/read/28941700/effect-of-nitrate-and-nitrite-on-listeria-and-selected-spoilage-bacteria-inoculated-in-dry-cured-ham
#7
Xavier F Hospital, Eva Hierro, Jacint Arnau, José Carballo, Juan S Aguirre, Marta Gratacós-Cubarsí, Manuela Fernández
The effect of nitrate and the combination of nitrate/nitrite on Listeria innocua (as surrogate of Listeria monocytogenes). And two selected spoilage microorganisms (Proteus vulgaris and Serratia liquefaciens) was studied in dry-cured ham. Hams were manufactured with different concentrations of curing agents: KNO3 (600 and 150mg/kg) alone or in combination with NaNO2 (600 and 150mg/kg). The addition of 500mg/kg of sodium ascorbate was also evaluated in a batch with 600mg/kg of nitrate and nitrite. The target microorganisms were inoculated by injection in semimembranosus, biceps femoris and in the shank, prior to curing...
November 2017: Food Research International
https://www.readbyqxmd.com/read/28859443/imbalance-in-mitochondrial-dynamics-and-apoptosis-in-pregnancies-among-hiv-infected-women-on-haart-with-obstetric-complications
#8
Mariona Guitart-Mampel, A Sandra Hernandez, Constanza Moren, Marc Catalan-Garcia, Ester Tobias, Ingrid Gonzalez-Casacuberta, Diana L Juarez-Flores, Josep M Gatell, Francesc Cardellach, Jose C Milisenda, Josep M Grau, Eduard Gratacos, Francesc Figueras, Gloria Garrabou
Background: HIV infection and HAART trigger genetic and functional mitochondrial alterations leading to cell death and adverse clinical manifestations. Mitochondrial dynamics enable mitochondrial turnover and degradation of damaged mitochondria, which may lead to apoptosis. Objectives: To evaluate markers of mitochondrial dynamics and apoptosis in pregnancies among HIV-infected women on HAART and determine their potential association with obstetric complications...
September 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28837585/a-two-dimensional-electromechanical-model-of-a-cardiomyocyte-to-assess-intra-cellular-regional-mechanical-heterogeneities
#9
Patricia Garcia-Canadilla, Jose F Rodriguez, Maria J Palazzi, Anna Gonzalez-Tendero, Patrick Schönleitner, Vedrana Balicevic, Sven Loncaric, Joost J F P Luiken, Mario Ceresa, Oscar Camara, Gudrun Antoons, Fatima Crispi, Eduard Gratacos, Bart Bijnens
Experimental studies on isolated cardiomyocytes from different animal species and human hearts have demonstrated that there are regional differences in the Ca2+ release, Ca2+ decay and sarcomere deformation. Local deformation heterogeneities can occur due to a combination of factors: regional/local differences in Ca2+ release and/or re-uptake, intra-cellular material properties, sarcomere proteins and distribution of the intracellular organelles. To investigate the possible causes of these heterogeneities, we developed a two-dimensional finite-element electromechanical model of a cardiomyocyte that takes into account the experimentally measured local deformation and cytosolic [Ca2+] to locally define the different variables of the constitutive equations describing the electro/mechanical behaviour of the cell...
2017: PloS One
https://www.readbyqxmd.com/read/28818743/learning-and-combining-image-neighborhoods-using-random-forests-for-neonatal-brain-disease-classification
#10
Veronika A Zimmer, Ben Glocker, Nadine Hahner, Elisenda Eixarch, Gerard Sanroma, Eduard Gratacós, Daniel Rueckert, Miguel Ángel González Ballester, Gemma Piella
It is challenging to characterize and classify normal and abnormal brain development during early childhood. To reduce the complexity of heterogeneous data population, manifold learning techniques are increasingly applied, which find a low-dimensional representation of the data, while preserving all relevant information. The neighborhood definition used for constructing manifold representations of the population is crucial for preserving the similarity structure and it is highly application dependent. The recently proposed neighborhood approximation forests learn a neighborhood structure in a dataset based on a user-defined distance...
August 9, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28813701/uterine-cervical-length-measurement-to-reduce-length-of-stay-in-patients-admitted-for-threatened-preterm-labor-a-randomized-trial
#11
Montse Palacio, Javier Caradeux, Miriam Sánchez, Teresa Cobo, Francesc Figueras, Oriol Coll, Eduard Gratacós, Vicenç Cararach
OBJECTIVE: To study whether knowledge of cervical length (CL) is useful in reducing the length of hospital stay in women admitted because of threatened preterm labor. METHODS: We performed a single-center, parallel, randomized trial at the Hospital Clínic of Barcelona. Inclusion criteria were single pregnancy, gestational age (GA) between 24+0 and 35+6 weeks, Bishop score <6, no parturition within 24-48 h after admission, and no clinical signs of chorioamnionitis, vaginal bleeding, or nonreassuring fetal status...
August 17, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28782233/re-descriptive-analysis-of-different-phenotypes-of-cardiac-remodeling-in-fetal-growth-restriction-m-rodr%C3%A3-guez-l%C3%A3-pez-m-cruz-lemini-b-valenzuela-alcaraz-l-garcia-otero-m-sitges-b-bijnens-e-gratac%C3%A3-s-and-f-crispi-ultrasound-obstet-gynecol-2017-50-207-214
#12
COMMENT
https://www.readbyqxmd.com/read/28782171/longitudinal-growth-assessment-for-the-prediction-of-adverse-perinatal-outcome-in-sga-suspected-fetuses
#13
Javier Caradeux, Elisenda Eixarch, Edurne Mazarico, Tri Rahmat Basuki, Eduard Gratacos, Francesc Figueras
BACKGROUND: Fetal growth restriction (FGR) is associated with an increased risk of adverse perinatal outcome (APO). However, distinguishing this condition from smallness-for-gestational age remains elusive. A set of criteria has recently been proposed for such purpose, including the severity of smallness, Doppler parameters and growth velocity. OBJECTIVES: To establish whether the use of growth velocity adds to Doppler evaluation in predicting APO among SGA-suspected fetuses...
August 7, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28743114/cervical-alpha-actinin-4-is-upregulated-in-women-with-threatened-preterm-labor-and-microbial-invasion-of-the-amniotic-cavity
#14
Teresa Cobo, Montse Palacio, Maribel Grande, Ana B Sánchez-García, Josep M Estanyol, Marta López, Jordi Bosch, Cristina Martí, Eduard Gratacós
OBJECTIVE: To characterize the proteome profile of women with threatened preterm labor (PTL) below 34;0 weeks with and without microbial invasion of the amniotic cavity (MIAC) using mass spectrometry in the amniotic fluid (AF) and Western blot analysis in the cervical mucus and the vaginal fluid. SUBJECTS AND METHODS: In the discovery phase, a case-control study including 8 women with MIAC and 7 without matched for gestational age at sampling was performed. Proteomic profile characterization was done using the LTQ VELOS Orbitrap mass spectrometer in the AF...
July 26, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28737543/a-program-aimed-at-reducing-anxiety-in-pregnant-women-diagnosed-with-a-small-for-gestational-age-fetus-evaluative-findings-from-a-spanish-study
#15
Ángela Arranz Betegón, Marta García, Sandra Parés, Gala Montenegro, Georgina Feixas, Nelly Padilla, Alba Camacho, Josefina Goberna, Francesc Botet, Eduard Gratacós
The objective of this study was to evaluate the effect of anxiety-reducing techniques including music therapy, sophrology, and creative visualization in pregnant women with a fetus diagnosed as small for gestational age and improved fetal and neonatal weight. This was a quasi-experimental study with a nonrandomized clinical trial design. We compared 2 groups of pregnant women with a fetus diagnosed as small for gestational age with no abnormalities on Doppler studies. The control group (n = 93) received standard care, and the intervention group (n = 65), in addition to standard care, underwent a program of 6 sessions led by a midwife or nurse who taught anxiety-reduction techniques...
July 2017: Journal of Perinatal & Neonatal Nursing
https://www.readbyqxmd.com/read/28734458/rett-like-severe-encephalopathy-caused-by-a-de%C3%A2-novo-grin2b-mutation-is-attenuated-by-d-serine-dietary-supplement
#16
David Soto, Mireia Olivella, Cristina Grau, Judith Armstrong, Clara Alcon, Xavier Gasull, Macarena Gómez de Salazar, Esther Gratacòs-Batlle, David Ramos-Vicente, Víctor Fernández-Dueñas, Francisco Ciruela, Àlex Bayés, Carlos Sindreu, Anna López-Sala, Àngels García-Cazorla, Xavier Altafaj
BACKGROUND: N-Methyl-D-aspartate receptors (NMDARs) play pivotal roles in synaptic development, plasticity, neural survival, and cognition. Despite recent reports describing the genetic association between de novo mutations of NMDAR subunits and severe psychiatric diseases, little is known about their pathogenic mechanisms and potential therapeutic interventions. Here we report a case study of a 4-year-old Rett-like patient with severe encephalopathy carrying a missense de novo mutation in GRIN2B(p...
June 16, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28719908/ultrasound-guided-intrauterine-labeling-of-rat-fetuses
#17
Hatice Gulcin Gumus, Miriam Illa, Laura Pla, Anna Gonzalez, Elena Demicheva, David Ley, Fatima Crispi, Eduard Gratacos
AIM: To compare intra-amniotic versus fetal subcutaneous injections for selective fetal labeling in multifetal rat pregnancies. METHODS: A total of 14 pregnant rats were randomized to receive intra-amniotic injections of dyes (including Fluorescein, Indigo Carmine, or Evans Blue) or fetal subcutaneous injections (of commercial tattoo ink) both guided by ultrasound at 15-17 days of gestation. Survival, injection, and labeling success rates of both techniques were compared...
July 18, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28719900/second-to-third-trimester-longitudinal-growth-assessment-for-the-prediction-of-largeness-for-gestational-age-and-macrosomia-in-an-unselected-population
#18
Javier Caradeux, Elisenda Eixarch, Edurne Mazarico, Tri Rahmat Basuki, Eduard Gratacós, Francesc Figueras
BACKGROUND: Prenatal detection of excessive growth remains inaccurate. Most strategies rely on a single cross-sectional evaluation of fetal size during the third trimester. OBJECTIVES: To compare second- to third-trimester longitudinal growth assessment with cross-sectional evaluation at the third trimester in the prediction of largeness for gestational age (LGA) and macrosomia. METHODS: A cohort of 2,696 unselected singleton pregnancies scanned at 21 ± 2 and 32 ± 2 weeks was created...
July 13, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28695336/experimentally-induced-intrauterine-growth-restriction-in-rabbits-leads-to-differential-remodelling-of-left-versus-right-ventricular-myocardial-microstructure
#19
Julia Schipke, Anna Gonzalez-Tendero, Lidia Cornejo, Alper Willführ, Bart Bijnens, Fatima Crispi, Christian Mühlfeld, Eduard Gratacós
Intrauterine growth restriction (IUGR) is associated with foetal cardiac remodelling and dysfunction together with increased risk of cardiovascular disease in adulthood. Experimental data concerning effects of IUGR on cardiomyocyte and microvascularization anatomy are inconsistent and it is unknown whether both ventricles are similarly susceptible to in utero undersupply. Foetal IUGR was induced in pregnant rabbits at 25 days of gestation by selective ligation of uteroplacental vessels. Foetal echocardiography showed systolic and diastolic dysfunction of both ventricles and body and heart weight were significantly reduced in response to IUGR...
November 2017: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/28681952/re-differential-effect-of-assisted-reproductive-technology-and-small-for-gestational-age-on-fetal-cardiac-remodeling-b-valenzuela-alcaraz-f-crispi-m-cruz-lemini-b-bijnens-l-garc%C3%A3-a-otero-m-sitges-j-balasch-and-e-gratac%C3%A3-s-ultrasound-obstet-gynecol-2017-50-63
#20
COMMENT
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