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https://www.readbyqxmd.com/read/29778069/differential-correlations-between-maternal-hair-levels-of-tobacco-and-alcohol-with-fetal-growth-restriction-clinical-subtypes
#1
Sally Sabra, Ebba Malmqvist, Laura Almeida, Eduard Gratacos, Maria Dolores Gomez Roig
Maternal exposure to tobacco and alcohol is a known cause, among others, for fetal growth restriction (FGR). Clinically, FGR can be subclassified into two forms: intrauterine growth restriction (IUGR) and small for gestational age (SGA), based on the severity of the growth retardation, and abnormal uterine artery Doppler or cerebro-placental ratio. This study aimed at investigating any differential correlation between maternal exposures to these toxins with the two clinical forms of FGR. Therefore, a case-control study was conducted in Barcelona, Spain...
January 4, 2018: Alcohol
https://www.readbyqxmd.com/read/29770109/fetoscopic-endoluminal-tracheal-occlusion-and-reestablishment-of-fetal-airways-for-congenital-diaphragmatic-hernia
#2
Lennart Van der Veeken, Francesca Maria Russo, Luc De Catte, Eduard Gratacos, Alexandra Benachi, Yves Ville, Kypros Nicolaides, Christoph Berg, Glenn Gardener, Nicola Persico, Pietro Bagolan, Greg Ryan, Michael A Belfort, Jan Deprest
Background: Congenital diaphragmatic hernia (CDH) is a congenital anomaly with high mortality and morbidity mainly due to pulmonary hypoplasia and hypertension. Temporary fetal tracheal occlusion to promote prenatal lung growth may improve survival. Entrapment of lung fluid stretches the airways, leading to lung growth. Methods: Fetal endoluminal tracheal occlusion (FETO) is performed by percutaneous sono-endoscopic insertion of a balloon developed for interventional radiology...
2018: Gynecological Surgery
https://www.readbyqxmd.com/read/29767953/pharmacological-and-electrophysiological-characterization-of-novel-nmda-receptor-antagonists
#3
Rosana Leiva, Matthew B Phillips, Andreea Larisa Turcu, Esther Gratacòs-Batlle, Lara León-García, Francesc X Sureda, David Soto, Jon W Johnson, Santiago Vazquez
This work reports the synthesis, and pharmacological and electrophysiological evaluation of new N-methyl-D-aspartic acid receptor (NMDAR) channel blocking antagonists featuring polycyclic scaffolds. Changes in the chemical structure modulate the potency and voltage dependence of inhibition. Two of the new antagonists display properties comparable to those of memantine, a clinically approved NMDAR antagonist.
May 16, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29745878/should-over-treatment-of-axial-spondyloarthritis-with-biologics-remain-a-concern-after-the-issue-of-the-new-asas-criteria-data-from-regisponserbio-spanish-register-of-biological-therapy-in-spondyloarthritides
#4
Mireia Moreno, Jordi Gratacós, Victoria Navarro-Compán, Eugenio de Miguel, Pilar Font, Teresa Clavaguera, Luis Francisco Linares, Beatriz Joven, Xavier Juanola
OBJECTIVES: To study whether disease status at treatment initiation has changed after the issue of the ASAS classification criteria. METHODS: REGISPONSERBIO registers patients with axial spondyloarthritis (axSpA) on biological treatment since 2013. It includes patients starting biological treatment (incident) or already on biological therapies (prevalent). Patients in both groups were compared in terms of: age at disease onset and at treatment start, disease duration, gender, HLA-B27, body mass index (BMI), BASDAI, BASFI, C-reactive protein, ESR, metrological data, ASQoL, WAPAI, extra-articular manifestations, comorbidities, radiological study, type of biological treatment and concomitant treatments...
May 8, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29714031/an-uncommon-presentation-of-alcoholic-liver-disease
#5
Jordi Gratacós-Ginès, Gerhard Jung, Alba Díaz, Xavier Forns
A 28-year-old man with previous medical history of chronic alcohol intake (>100g/day) was admitted into the hospital with jaundice and asthenia since the last 2 weeks. His alcohol consume had increased lately. Except for jaundice, physical examination was non relevant. Laboratory tests indicated: ASAT/ALAT 936/100 UI/L, Total bilirubin 26 mg/dl (predominantly direct), GGT 1021 UI/L, AP 327 UI/L, total cholesterol 335 mg/dl, triglycerides 515 mg/dl, platelet count 86x10^12/L, INR 1.74; white blood cell count and creatinine levels were normal...
April 30, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29673050/postnatal-persistence-of-fetal-cardiovascular-remodeling-associated-with-assisted-reproductive-technologies-a-cohort-study
#6
Brenda Valenzuela-Alcaraz, Audrey Serafini, Alvaro Sepulveda-Martínez, Gemma Casals, Merida Rodríguez-López, Laura Garcia-Otero, Monica Cruz-Lemini, Bart Bijnens, Marta Sitges, Juan Balasch, Eduard Gratacos, Fatima Crispi
OBJECTIVE: to assess the postnatal persistence of fetal cardiovascular remodeling associated to assisted reproductive technologies (ART), in children at 3 years of age. DESIGN: A cohort study of children conceived by ART. SETTING: Maternal-Fetal Medicine Unit, Hospital Clinic Barcelona, Spain. POPULATION SAMPLE: 80 singleton pregnancies conceived by ART and 80 spontaneously conceived (controls) followed from fetal life up to childhood...
April 19, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29626979/placental-exosomes-profile-in-maternal-and-fetal-circulation-in-intrauterine-growth-restriction-liquid-biopsies-to-monitoring-fetal-growth
#7
Jezid Miranda, Cristina Paules, Soumyalekshmi Nair, Andrew Lai, Carlos Palma, Katherin Scholz-Romero, Gregory E Rice, Eduard Gratacos, Fatima Crispi, Carlos Salomon
INTRODUCTION: Placenta-derived exosomes may represent an additional pathway by which the placenta communicates with the maternal system to induce maternal vascular adaptations to pregnancy and it may be affected during Fetal growth restriction (FGR). The objective of this study was to quantify the concentration of total and placenta-derived exosomes in maternal and fetal circulation in small fetuses classified as FGR or small for gestational age (SGA). METHODS: Prospective cohort study in singleton term gestations including 10 normally grown fetuses and 20 small fetuses, sub-classified into SGA and FGR accordingly to birth weight (BW) percentile and fetoplacental Doppler...
April 2018: Placenta
https://www.readbyqxmd.com/read/29572873/characterizing-cardiac-dysfunction-in-fetuses-with-left-congenital-diaphragmatic-hernia
#8
Mónica Cruz-Lemini, Brenda Valenzuela-Alcaraz, Julio Granados-Montiel, Josep M Martínez, Fátima Crispi, Eduard Gratacós, Rogelio Cruz-Martínez
OBJECTIVE: To evaluate cardiac function by conventional echocardiography and tissue Doppler imaging in fetuses with left congenital diaphragmatic hernia (CDH). METHODS: Conventional echocardiography (myocardial performance index, ventricular filling velocities, and E/A ratios) and tissue Doppler imaging (annular myocardial peak velocities, E/E' and E'/A' ratios) in mitral, septal, and tricuspid annulus were evaluated in a cohort of 31 left-sided CDH fetuses and compared with 75 controls matched for gestational age 2:1...
March 23, 2018: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29560285/mid-trimester-cervical-consistency-index-and-cervical-length-to-predict-spontaneous-preterm-birth-in-a-high-risk-population
#9
Núria Baños, Carla Julià, Núria Lorente, Silvia Ferrero, Teresa Cobo, Eduard Gratacos, Montse Palacio
Background  Short cervical length (CL) has not been shown to be adequate as a single predictor of spontaneous preterm birth (sPTB) in high-risk pregnancies. Objective  The objective of this study was to evaluate the performance of the mid-trimester cervical consistency index (CCI) to predict sPTB in a cohort of high-risk pregnancies and to compare the results with those obtained with the CL. Study Design  Prospective cohort study including high-risk singleton pregnancies between 19 +0 and 24 +6 weeks...
January 2018: American Journal of Perinatology Reports
https://www.readbyqxmd.com/read/29496420/current-status-of-multidisciplinary-care-in-psoriatic-arthritis-in-spain-nexus-2-0-project
#10
Rubén Queiro, Pablo Coto, Beatriz Joven, Raquel Rivera, Teresa Navío Marco, Pablo de la Cueva, Jose Luis Alvarez Vega, Basilio Narváez Moreno, Fernando José Rodriguez Martínez, José Pardo Sánchez, Carlos Feced Olmos, Conrad Pujol, Jesús Rodríguez, Jaume Notario, Manel Pujol Busquets, Mercè García Font, Eva Galindez, Silvia Pérez Barrio, Ana Urruticoechea-Arana, Merce Hergueta, M Dolores López Montilla, Antonio Vélez García-Nieto, Francisco Maceiras, Laura Rodríguez Pazos, Esteban Rubio Romero, Lourdes Rodríguez Fernandez Freire, Jesús Luelmo, Jordi Gratacós
OBJECTIVE: 1) To analyze the implementation of multidisciplinary care models in psoriatic arthritis (PsA) patients, 2) To define minimum and excellent standards of care. METHODS: A survey was sent to clinicians who already performed multidisciplinary care or were in the process of undertaking it, asking: 1) Type of multidisciplinary care model implemented; 2) Degree, priority and feasibility of the implementation of quality standards in the structure, process and result for care...
February 26, 2018: Reumatología Clinica
https://www.readbyqxmd.com/read/29486850/remodeling-of-the-cardiovascular-circulation-in-fetuses-of-mothers-with-diabetes-a-fetal-computational-model-analysis
#11
Aparna Kulkarni, Patricia Garcia-Cañadilla, Abdullah Khan, Jose Miguel Lorenzo, Karen Beckerman, Brenda Valenzuela-Alcaraz, Monica Cruz-Lemini, Olga Gomez, Eduard Gratacos, Fatima Crispi, Bart Bijnens
AIMS: Myocardial structural and functional abnormalities are known to occur in fetuses of mothers with diabetes mellitus (FMDM). The main aim of this investigation was to explore the cardiovascular circulatory patterns in FMDM using a validated lumped computational model of the cardiovascular system. METHODS: This was a multi-institutional study involving FMDM compared to fetuses of maternal controls (FC). Fetal echocardiographic Doppler data from left and right ventricular outflow tracts, aortic isthmus, middle cerebral and umbilical arteries were fitted into a validated fetal circulation computational model to estimate patient-specific placental and vascular properties...
March 2018: Placenta
https://www.readbyqxmd.com/read/29466434/nutritional-intra-amniotic-therapy-increases-survival-in-a-rabbit-model-of-fetal-growth-restriction
#12
Hatice Gulcin Gumus, Miriam Illa, Laura Pla, Monica Zamora, Fatima Crispi, Eduard Gratacos
OBJECTIVE: To evaluate the perinatal effects of a prenatal therapy based on intra-amniotic nutritional supplementation in a rabbit model of intrauterine growth restriction (IUGR). METHODS: IUGR was surgically induced in pregnant rabbits at gestational day 25 by ligating 40-50% of uteroplacental vessels of each gestational sac. At the same time, modified-parenteral nutrition solution (containing glucose, amino acids and electrolytes) was injected into the amniotic sac of nearly half of the IUGR fetuses (IUGR-T group n = 106), whereas sham injections were performed in the rest of fetuses (IUGR group n = 118)...
2018: PloS One
https://www.readbyqxmd.com/read/29458235/altered-cortical-development-in-fetuses-with-isolated-nonsevere-ventriculomegaly-assessed-by-neurosonography
#13
Nadine Hahner, Bienvenido Puerto, Miriam Perez-Cruz, Catarina Policiano, Elena Monterde, Fatima Crispi, Eduard Gratacos, Elisenda Eixarch
OBJECTIVES: To perform a comprehensive assessment of cortical development in fetuses with isolated nonsevere ventriculomegaly (INSVM) by neurosonography. METHODS: We prospectively included 40 fetuses with INSVM and 40 controls. INSVM was defined as atrial width between 10.0 and 14.9 mm without associated malformation, infection, or chromosomal abnormality. Cortical development was assessed by neurosonography at 26 and 30 weeks of gestation measuring depth of selected sulci and applying a maturation scale from 0 (no appearance) to 5 (maximally developed) of main sulci and areas...
April 2018: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29452236/cardiac-and-placental-mitochondrial-characterization-in-a-rabbit-model-of-intrauterine-growth-restriction
#14
M Guitart-Mampel, A Gonzalez-Tendero, S Niñerola, C Morén, M Catalán-Garcia, I González-Casacuberta, D L Juárez-Flores, O Ugarteburu, L Matalonga, M V Cascajo, F Tort, A Cortés, E Tobias, J C Milisenda, J M Grau, F Crispi, E Gratacós, G Garrabou, F Cardellach
BACKGROUND: Intrauterine growth restriction (IUGR) is associated with cardiovascular remodeling persisting into adulthood. Mitochondrial bioenergetics, essential for embryonic development and cardiovascular function, are regulated by nuclear effectors as sirtuins. A rabbit model of IUGR and cardiovascular remodeling was generated, in which heart mitochondrial alterations were observed by microscopic and transcriptomic analysis. We aimed to evaluate if such alterations are translated at a functional mitochondrial level to establish the etiopathology and potential therapeutic targets for this obstetric complication...
May 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29447050/added-value-of-cerebro-placental-ratio-and-uterine-artery-doppler-at-routine-third-trimester-screening-as-a-predictor-of-sga-and-fgr-in-non-selected-pregnancies
#15
M Rial-Crestelo, R J Martinez-Portilla, A Cancemi, J Caradeux, L Fernandez, A Peguero, E Gratacos, Francesc Figueras
OBJECTIVES: The objective of this study is to determine the added value of cerebroplacental ratio (CPR) and uterine Doppler velocimetry at third trimester scan in an unselected obstetric population to predict smallness and growth restriction. METHODS: We constructed a prospective cohort study of women with singleton pregnancies attended for routine third trimester screening (32+0 -34+6 weeks). Fetal biometry and fetal-maternal Doppler ultrasound examinations were performed by certified sonographers...
March 4, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29431014/comparison-of-2d-versus-m-mode-echocardiography-for-assessing-fetal-myocardial-wall-thickness
#16
Alvaro Sepúlveda-Martínez, Laura García-Otero, Iris Soveral, Laura Guirado, Brenda Valenzuela-Alcaraz, Ximena Torres, Mérida Rodriguez-Lopez, Eduard Gratacos, Olga Gómez, Fàtima Crispi
OBJECTIVE: M-mode and 2D have been proposed for evaluating fetal myocardial thickness. However, studies comparing the performance of both modalities are lacking. We aimed to compare 2D versus M-mode reproducibility for assessing myocardial wall thicknesses. METHODS: A prospective study including 45 healthy fetuses from low-risk pregnancies evaluated between 18 and 41 weeks of gestation. Left and right ventricular free-wall and septal myocardial thicknesses were measured at end-diastole (ED) and end-systole (ES) in transverse 4-chamber view using 2D and M-mode...
February 11, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29422215/long-term-cardiovascular-consequences-of-fetal-growth-restriction-biology-clinical-implications-and-opportunities-for-prevention-of-adult-disease
#17
REVIEW
Fatima Crispi, Jezid Miranda, Eduard Gratacós
In the modern world, cardiovascular disease is a leading cause of death for both men and women. Epidemiologic studies consistently have suggested an association between low birthweight and/or fetal growth restriction and increased rate of cardiovascular mortality in adulthood. Furthermore, experimental and clinical studies have demonstrated that sustained nutrient and oxygen restriction that are associated with fetal growth restriction activate adaptive cardiovascular changes that might explain this association...
February 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29422212/diagnosis-and-surveillance-of-late-onset-fetal-growth-restriction
#18
REVIEW
Francesc Figueras, Javier Caradeux, Fatima Crispi, Elisenda Eixarch, Anna Peguero, Eduard Gratacos
By consensus, late fetal growth restriction is that diagnosed >32 weeks. This condition is mildly associated with a higher risk of perinatal hypoxic events and suboptimal neurodevelopment. Histologically, it is characterized by the presence of uteroplacental vascular lesions (especially infarcts), although the incidence of such lesions is lower than in preterm fetal growth restriction. Screening procedures for fetal growth restriction need to identify small babies and then differentiate between those who are healthy and those who are pathologically small...
February 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29417210/standards-of-care-and-quality-indicators-for-multidisciplinary-care-models-for-psoriatic-arthritis-in-spain
#19
Jordi Gratacós, Jesús Luelmo, Jesús Rodríguez, Jaume Notario, Teresa Navío Marco, Pablo de la Cueva, Manel Pujol Busquets, Mercè García Font, Beatriz Joven, Raquel Rivera, Jose Luis Alvarez Vega, Antonio Javier Chaves Álvarez, Ricardo Sánchez Parera, Jose Carlos Ruiz Carrascosa, Fernando José Rodríguez Martínez, José Pardo Sánchez, Carlos Feced Olmos, Conrad Pujol, Eva Galindez, Silvia Pérez Barrio, Ana Urruticoechea Arana, Mercedes Hergueta, Pablo Coto, Rubén Queiro
To define and give priority to standards of care and quality indicators of multidisciplinary care for patients with psoriatic arthritis (PsA). A systematic literature review on PsA standards of care and quality indicators was performed. An expert panel of rheumatologists and dermatologists who provide multidisciplinary care was established. In a consensus meeting group, the experts discussed and developed the standards of care and quality indicators and graded their priority, agreement and also the feasibility (only for quality indicators) following qualitative methodology and a Delphi process...
February 7, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29387528/cortical-folding-alterations-in-fetuses-with-isolated-non-severe-ventriculomegaly
#20
Oualid M Benkarim, Nadine Hahner, Gemma Piella, Eduard Gratacos, Miguel Angel González Ballester, Elisenda Eixarch, Gerard Sanroma
Neuroimaging of brain diseases plays a crucial role in understanding brain abnormalities and early diagnosis. Of great importance is the study of brain abnormalities in utero and the assessment of deviations in case of maldevelopment. In this work, brain magnetic resonance images from 23 isolated non-severe ventriculomegaly (INSVM) fetuses and 25 healthy controls between 26 and 29 gestational weeks were used to identify INSVM-related cortical folding deviations from normative development. Since these alterations may reflect abnormal neurodevelopment, our working hypothesis is that markers of cortical folding can provide cues to improve the prediction of later neurodevelopmental problems in INSVM subjects...
2018: NeuroImage: Clinical
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