Jiakun Yu, Ms Glaucia Miranda Varella Pereira, Kristina Allen-Brady, Romana Cuffolo, Aditi Siddharth, Marianne Koch, John W F Chua, Felice Sorrentino, Oskar Dytko, Kaa-Yung Ng, Philippe Violette, Vik Khullar, Zhan Tao Wang, Rufus Cartwright
INTRODUCTION: The lifetime risk of urinary tract infection (UTI) is known from first-degree relative studies to be highly heritable. Associations have also been observed across the life course from paediatric UTI to recurrent UTI in adulthood, suggesting lifelong susceptibility factors. Candidate gene studies and genome-wide association studies have tested for genetic associations of UTI, but no contemporary systematic synthesis of studies is available. OBJECTIVE: We conducted a systematic review to identify all genetic polymorphisms tested for an association with UTI in children and adults, and to assess their strength, consistency, and risk of bias among reported associations...
December 19, 2023: American Journal of Obstetrics and Gynecology