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Community acquired pneumonia

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https://www.readbyqxmd.com/read/28449020/s-pneumoniae-purulent-pericarditis-in-the-setting-of-community-acquired-pneumonia
#1
Andrew Chatfield, Timothy Glenie, Sarah Fitzsimons, Krish Chaudhuri, Khang-Li Looi
No abstract text is available yet for this article.
April 28, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28449003/pneumonia-severity-assessment-tools-for-predicting-mortality-in-patients-with-healthcare-associated-pneumonia-a-systematic-review-and-meta-analysis
#2
Shingo Noguchi, Kazuhiro Yatera, Toshinori Kawanami, Yoshihisa Fujino, Hiroshi Moro, Nobumasa Aoki, Kosaku Komiya, Jun-Ichi Kadota, Nobuaki Shime, Hiroki Tsukada, Shigeru Kohno, Hiroshi Mukae
BACKGROUND: In contrast to community-acquired pneumonia (CAP), no specific severity assessment tools have been developed for healthcare-associated pneumonia (HCAP) in clinical practice. OBJECTIVES: In this review, we assessed the clinical significance of severity assessment tools for HCAP. METHODS: We identified related articles from the PubMed database. The eligibility criteria were original research articles evaluating severity scoring tools and reporting the outcomes of mortality in patients with HCAP...
April 28, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/28446576/diagnostic-value-of-the-galactomannan-antigen-test-in-serum-and-bronchoalveolar-lavage-fluid-samples-from-patients-with-non-neutropenic-invasive-pulmonary-aspergillosis
#3
Wei Zhou, Hongxing Li, Yan Zhang, Mei Huang, Qian He, Pei Li, Fang Zhang, Yi Shi, Xin Su
Objective: To compare the diagnostic value of galactomannan (GM) detection in bronchoalveolar lavage fluid (BALF) and serum samples from non-neutropenic patients with invasive pulmonary aspergillosis (IPA), and determine the optimal BALF GM cut-off value for pulmonary aspergillosis.Methods: GM detection in BALF and serum samples was performed by enzyme-linked immunosorbent assay (ELISA) in 128 patients with clinically suspected non-neutropenic pulmonary aspergillosis between June 2014 and June 2016. On the basis of the clinical and pathological diagnoses, 8 patients were excluded because their diagnosis was uncertain...
April 26, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28438301/typical-presentation-of-legionella-pneumophila-community-acquired-pneumonia
#4
EDITORIAL
C Cilloniz, A Torres
No abstract text is available yet for this article.
May 2017: Revista Portuguesa de Pneumologia
https://www.readbyqxmd.com/read/28432048/solithromycin-a-novel-ketolide-antibiotic
#5
Michael J Buege, Jack E Brown, Samuel L Aitken
PURPOSE: The pharmacology, pharmacokinetics, pharmacodynamics, antimicrobial activity, clinical safety, and current regulatory status of solithromycin are reviewed. SUMMARY: Solithromycin is a novel ketolide antibiotic developed for the treatment of community-acquired bacterial pneumonia (CABP). Its pharmacologic, pharmacokinetic, and pharmacodynamic properties provide activity against a broad range of intracellular organisms, including retained activity against pathogens displaying various mechanisms of macrolide resistance...
April 21, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28431414/intratracheal-instillation-of-neutrophils-rescues-bacterial-overgrowth-initiated-by-trauma-damage-associated-molecular-patterns
#6
Kiyoshi Itagaki, Ingred Riça, Jing Zhang, Dave Gallo, Melissa DePrato, Leo E Otterbein, Carl J Hauser
BACKGROUND: Nosocomial pneumonias are common in trauma patients and so interventions to prevent and treat nosocomial pneumonia may improve outcomes. Our prior work strongly suggests that tissue injury predisposes to infections like nosocomial pneumonia because mitochondrial debris originating from injured cells contains damage-associated molecular patterns that can reduce neutrophil (PMN) migration into the airway and diminish PMN function in response to bacterial inoculation of the airway...
May 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28427381/penicillin-treatment-for-patients-with-community-acquired-pneumonia-in-denmark-a-retrospective-cohort-study
#7
Gertrud Baunbæk Egelund, Andreas Vestergaard Jensen, Stine Bang Andersen, Pelle Trier Petersen, Bjarne Ørskov Lindhardt, Christian von Plessen, Gernot Rohde, Pernille Ravn
BACKGROUND: Community-acquired pneumonia (CAP) is a severe infection, with high mortality. Antibiotic strategies for CAP differ across Europe. The objective of the study was to describe the epidemiology of CAP in Denmark and evaluate the prognosis of patients empirically treated with penicillin-G/V monotherapy. METHODS: Retrospective cohort study including hospitalized patients with x-ray confirmed CAP. We calculated the population-based incidence, reviewed types of empiric antibiotics and duration of antibiotic treatment...
April 20, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28426811/procalcitonin-for-selecting-the-antibiotic-regimen-in-outpatients-with-low-risk-community-acquired-pneumonia-using-a-rapid-point-of-care-testing-a-single-arm-clinical-trial
#8
Mar Masiá, Sergio Padilla, Victoria Ortiz de la Tabla, Matilde González, Cristina Bas, Félix Gutiérrez
OBJECTIVE: We aimed to assess the role of procalcitonin (PCT) to guide the initial selection of the antibiotic regimen for low-risk community-acquired pneumonia (CAP). METHODS: A single-arm clinical trial was conducted including outpatients with CAP and Pneumonia Severity Index risk classes I-II. Antimicrobial selection was based on the results of PCT measured with a rapid point-of-care testing. According to serum PCT levels, patients were assigned to two treatment strategies: oral azithromycin if PCT was <0...
2017: PloS One
https://www.readbyqxmd.com/read/28424077/plasma-metabolomics-for-the-diagnosis-and-prognosis-of-h1n1-influenza-pneumonia
#9
Mohammad M Banoei, Hans J Vogel, Aalim M Weljie, Anand Kumar, Sachin Yende, Derek C Angus, Brent W Winston
BACKGROUND: Metabolomics is a tool that has been used for the diagnosis and prognosis of specific diseases. The purpose of this study was to examine if metabolomics could be used as a potential diagnostic and prognostic tool for H1N1 pneumonia. Our hypothesis was that metabolomics can potentially be used early for the diagnosis and prognosis of H1N1 influenza pneumonia. METHODS: (1)H nuclear magnetic resonance spectroscopy and gas chromatography-mass spectrometry were used to profile the metabolome in 42 patients with H1N1 pneumonia, 31 ventilated control subjects in the intensive care unit (ICU), and 30 culture-positive plasma samples from patients with bacterial community-acquired pneumonia drawn within the first 24 h of hospital admission for diagnosis and prognosis of disease...
April 19, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28421245/research-in-community-acquired-pneumonia-the-next-steps
#10
Antoni Torres, Igancio Martín-Loeches, Rosario Menéndez
No abstract text is available yet for this article.
April 18, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28419820/community-acquired-infections-among-the-refugees-leading-to-intensive-care-unit-admissions-in-turkey
#11
Mediha Turktan, Oznur Ak, Hakan Erdem, Dilek Ozcengiz, Sally Hargreaves, Safak Kaya, Emre Karakoc, Ozlem Ozkan-Kuscu, Gunay Tuncer-Ertem, Recep Tekin, Handan Birbicer, Gul Durmus, Canan Yilmaz, Funda Kocak, Edmond Puca, Jordi Rello
OBJECTIVES: Data on the impact of refugees on Intensive Care Units (ICUs) are lacking in the literature, in particular for community-acquired (CA) infectious diseases, for which they are known to be at higher risk. We did a descriptive, multicenter study to analyze CA infections among refugee patients requiring ICU admission. METHODS: Inclusion criteria were adult refugee patients admitted to an ICU due to CA infections. Anonymized data were collected between January 1, 2010 and December 30, 2015 across 10 referral centers...
April 11, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28417242/combined-use-of-the-multidimensional-prognostic-index-mpi-and-procalcitonin-serum-levels-in-predicting-1-month-mortality-risk-in-older-patients-hospitalized-with-community-acquired-pneumonia-cap-a-prospective-study
#12
Alberto Pilotto, Simone Dini, Julia Daragjati, Manuela Miolo, Monica Maria Mion, Andrea Fontana, Mario Lo Storto, Martina Zaninotto, Alberto Cella, Paolo Carraro, Filomena Addante, Massimiliano Copetti, Mario Plebani
BACKGROUND: Several scores and biomarkers, i.e., procalcitonin (PCT), were proposed to stratify the mortality risk in community-acquired pneumonia (CAP). AIM: Evaluating prognostic accuracy of PCT and Multidimensional Prognostic Index (MPI) for 1-month mortality risk in older patients with CAP. METHODS: At hospital admission and at discharge, patients were evaluated by a Comprehensive Geriatric Assessment to calculate MPI. Serum PCT was measured at admission and 1, 3, and 5 days after hospital admission...
April 17, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28416961/predictive-factors-of-methicillin-resistant-staphylococcus-aureus-infection-in-elderly-patients-with-community-onset-pneumonia
#13
Hyeyoung Jwa, Jong Wook Beom, Jong Hoo Lee
BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) infection is a severe and life-threatening disease in patients with community-onset (CO) pneumonia. However, the current guidelines lack specificity for a screening test for MRSA infection. METHODS: This study was retrospectively conducted in elderly patients aged ≥65 years, who had contracted CO-pneumonia during hospitalization at the Jeju National University Hospital, between January 2012 and December 2014...
April 2017: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28414567/disease-burden-of-community-acquired-pneumonia-among-children-under-5%C3%A2-y-old-in-china-a-population-based-survey
#14
Yan Li, Zhijie An, Dapeng Yin, Yanmin Liu, Zhuoying Huang, Yujie Ma, Hui Li, Qi Li, Huaqing Wang
BACKGROUND: To obtain the baseline data on the incidence and cost of community acquired pneumonia among under-5 children for future studies, and provide evidence for shaping China's strategies regarding pneumococcal conjugate vaccine (PCV). METHODS: Three townships from Heilongjiang, Hebei and Gansu Province and one community in Shanghai were selected as study areas. A questionnaire survey was conducted to collect data on incidence and cost of pneumonia among children under 5 y old in 2012...
April 17, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28410813/post-hoc-analysis-of-a-randomized-controlled-trial-diabetes-mellitus-modifies-the-efficacy-of-the-13-valent-pneumococcal-conjugate-vaccine-in-elderly
#15
Susanne M Huijts, Cornelis H van Werkhoven, Marieke Bolkenbaas, Diederick E Grobbee, Marc J M Bonten
BACKGROUND: The 13-valent pneumococcal conjugate-vaccine (PCV13) was effective in preventing vaccine-type Community-Acquired Pneumonia (VT-CAP) and Invasive Pneumococcal Disease (VT-IPD) in elderly subjects, but vaccine efficacy (VE) in patients with comorbidities at time of vaccination is unknown. METHODS: This is a post hoc analysis of the CAPiTA study, a double blind, randomized controlled trial with 84,496 immunocompetent participants aged ⩾65years, receiving PCV13 or placebo vaccination...
April 12, 2017: Vaccine
https://www.readbyqxmd.com/read/28410311/extracorporeal-membrane-oxygenation-therapy-for-community-acquired-pneumonia-are-we-moving-the-dial
#16
Raquel R Bartz, Elliott Bennett-Guerrero
No abstract text is available yet for this article.
May 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28409125/colibactin-contributes-to-the-hypervirulence-of-pks-k1-cc23-klebsiella-pneumoniae-in-mouse-meningitis-infections
#17
Min-Chi Lu, Ying-Tsong Chen, Ming-Ko Chiang, Yao-Chen Wang, Pei-Yi Hsiao, Yi-Jhen Huang, Ching-Ting Lin, Ching-Chang Cheng, Chih-Lung Liang, Yi-Chyi Lai
Klebsiella pneumoniae is the most common pathogen of community-acquired meningitis in Taiwan. However, the lack of a physiologically relevant meningitis model for K. pneumoniae has impeded research into its pathogenesis mechanism. Based on the core genome MLST analyses, the hypervirulent K1 K. pneumoniae strains, which are etiologically implicated in adult meningitis, mostly belong to a single clonal complex, CC23. Some K1 CC23 K. pneumoniae strains carry a gene cluster responsible for colibactin production...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28408931/drug-induced-pneumonitis-secondary-to-treatment-with-paritaprevir-ritonavir-ombitasvir-and-dasabuvir-viekira-pak%C3%A2-for-chronic-hepatitis-c-case-report-of-an-unexpected-life-threatening-adverse-reaction
#18
Shih Yea Sylvia Wu, Bridget Faire, Edward Gane
VIEKIRA PAK (ritonavir-boosted paritaprevir/ombitasvir and dasabuvir) is an approved treatment for compensated patients with genotype 1 (GT1) chronic hepatitis C virus (HCV) infection. This oral regimen has minimal adverse effects and is well tolerated. Cure rates are 97% in patients infected with HCV GT 1a and 99% in those with HCV GT 1b. We report the first case of life-threatening allergic pneumonitis associated with VIEKIRA PAK. This unexpected serious adverse event occurred in a 68-year-old Chinese female with genotype 1b chronic hepatitis C and Child-Pugh A cirrhosis...
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/28407674/-strategies-for-the-treatment-of-community-acquired-pneumonia-in-hiv-positive-patients
#19
B T Schleenvoigt, J Rupp, G Rohde, J K Rockstroh, G Fätkenheuer, M W Pletz
Study purpose According to the Robert Koch Institute, 84,700 people in Germany suffer from HIV infection. One-third of the affected persons is over 50 years old. In Germany, community-acquired pneumonia (CAP) is a widespread disease with more than 250,000 cases per year. Incidence and mortality increase with the age of the affected individuals. For this reason, diagnostic and therapeutic strategies are needed to guide medical care of HIV-infected patients presenting with CAP. Methodology HIV therapists were interviewed about their diagnostic approach, risk stratification strategy and therapeutic approach to HIV-associated community-acquired pneumonia (HIV( +)/CAP) using a questionnaire...
April 2017: Pneumologie
https://www.readbyqxmd.com/read/28407209/neutrophil-to-lymphocyte-ratio-an-emerging-marker-predicting-prognosis-in-elderly-adults-with-community-acquired-pneumonia
#20
Emanuela Cataudella, Chiara M Giraffa, Salvatore Di Marca, Alfredo Pulvirenti, Salvatore Alaimo, Marcella Pisano, Valentina Terranova, Thea Corriere, Maria L Ronsisvalle, Rosario Di Quattro, Benedetta Stancanelli, Mauro Giordano, Carlo Vancheri, Lorenzo Malatino
OBJECTIVES: To explore the performance of the neutrophil-to-lymphocyte ratio (NLR), an index of systemic inflammation that predicts prognosis of several diseases, in a cohort of elderly adults with community-acquired pneumonia (CAP). DESIGN: Prospective clinical study from January 2014 to July 2016. SETTING: Unit of Internal Medicine, University of Catania, Catania, Italy. PARTICIPANTS: Elderly adults admitted for CAP (N = 195)...
April 13, 2017: Journal of the American Geriatrics Society
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