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gallium contrast media

Yi-Chuan Tseng, Yang-Chun Lee, Sih-Wei Chang, Tzu-Yao Lin, Dai-Liang Ma, Bo-Cheng Lin, Hsuen-Li Chen
In this study, we found that the large area of electromagnetic field hot zone induced through magnetic dipole resonance of metal-free structures can greatly enhance Raman scattering signals. The magnetic resonant nanocavities, based on high-refractive-index silicon nanoparticles (SiNPs), were designed to resonate at the wavelength of the excitation laser of the Raman system. The well-dispersed SiNPs that were not closely packed displayed significant magnetic dipole resonance and gave a Raman enhancement per unit volume of 59 347...
October 20, 2017: Nanotechnology
A Therese Soderlund, Jasper Chaal, Gabriel Tjio, John J Totman, Maurizio Conti, David W Townsend
UNLABELLED: This study aimed to investigate image quality for a comprehensive set of isotopes ((18)F, (11)C, (89)Zr, (124)I, (68)Ga, and (90)Y) on 2 clinical scanners: a PET/CT scanner and a PET/MR scanner. METHODS: Image quality and spatial resolution were tested according to NU 2-2007 of the National Electrical Manufacturers Association. An image-quality phantom was used to measure contrast recovery, residual bias in a cold area, and background variability. Reconstruction methods available on the 2 scanners were compared, including point-spread-function correction for both scanners and time of flight for the PET/CT scanner...
August 2015: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Martina Weineisen, Margret Schottelius, Jakub Simecek, Richard P Baum, Akin Yildiz, Seval Beykan, Harshad R Kulkarni, Michael Lassmann, Ingo Klette, Matthias Eiber, Markus Schwaiger, Hans-Jürgen Wester
UNLABELLED: On the basis of the high and consistent expression of prostate-specific membrane antigen (PSMA) in metastatic prostate cancer (PC), the goal of this study was the development, preclinical evaluation, and first proof-of-concept investigation of a PSMA inhibitor for imaging and therapy (PSMA I&T) for (68)Ga-based PET and (177)Lu-based endoradiotherapeutic treatment in patients with metastatic and castration-resistant disease. METHODS: PSMA I&T was synthesized in a combined solid phase and solution chemistry strategy...
August 2015: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Kuo-Shyan Lin, Guillaume Amouroux, Jinhe Pan, Zhengxing Zhang, Silvia Jenni, Joseph Lau, Zhibo Liu, Navjit Hundal-Jabal, Nadine Colpo, François Bénard
UNLABELLED: Bradykinin B1 receptor (B1R) is a G-protein-coupled receptor that is overexpressed in a variety of cancers. B1R is not expressed in healthy tissues, making it an attractive cancer imaging marker. Previously, we reported selective uptake of (68)Ga-P03034 ((68)Ga-DOTA-dPEG2-Lys-Arg-Pro-Hyp-Gly-Cha-Ser-Pro-Leu) in B1R-positive (B1R+) HEK293T::hB1R tumor xenografts in mice. In this study, we compare (68)Ga-P03034 with (68)Ga-labeled P04158 ((68)Ga-DOTA-dPEG2-Lys-Lys-Arg-Pro-Hyp-Gly-Igl-Ser-D-Igl-Oic) and Z02090 ((68)Ga-DOTA-dPEG2-Lys-Lys-Arg-Pro-Hyp-Gly-Cpg-Ser-D-Tic-Cpg) derived from 2 potent B1R antagonists, B9858 and B9958, respectively, for imaging B1R expression with PET...
April 2015: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Pooja Singh, Swati Aggarwal, Anjani K Tiwari, Vikas Kumar, Ramendra Pratap, Krishna Chuttani, Anil K Mishra
A novel transitional metal ligand derivatized from EDTA-conjugated 2-amino-4-methyl pyridine, an acyclic vehicle (EDTA-Mepy2 ) was designed, synthesized, and characterized for PET imaging with ⁶⁸Ga. The drug likeliness and appropriate lipophilicity were first analyzed by molecular docking studies which shows interactive property of ligand with serum albumin protein (HSA: PDB 1E78), at Lys199, Arg257, and His242 residues, which make it more appropriate in transportation as a specific ligand for PET imaging...
December 2014: Chemical Biology & Drug Design
Oliver Thews, Melanie Zimny, Elisabeth Eppard, Markus Piel, Nicole Bausbacher, Verena Nagel, Frank Rösch
PURPOSE: SPECT (e.g., with (99m)Tc-sestamibi) is routinely used for imaging myocardial damage, even though PET could offer a higher spatial resolution. Using the generator-gained isotope (68)Ga would allow a rapid supply of the tracer in the diagnostic unit. For this reason, the aim of the study was to develop (68)Ga-labeled PET tracers based on different Schiff base amines and to evaluate the cardiomyocyte uptake in vitro as well as the biodistribution of the tracers in vivo. PROCEDURES: Fifteen different Schiff bases (basing on 3 different backbones) were synthesized and labeled with (68)Ga...
December 2014: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
Qian Wang, Yang Yu, Keqin Pan, Jing Liu
Visualization on the anatomical vessel networks plays a vital role in the physiological or pathological investigations. However, so far it still remains a big challenge to identify the fine structures of the smallest capillary vessel networks via conventional imaging ways. Here, the room temperature liquid metal angiography was proposed for the first time to generate mega contrast X-ray images for multiscale vasculature mapping. Particularly, gallium was adopted as the room temperature liquid metal contrast agent and infused into the vessels of in vitro pig hearts and kidneys...
July 2014: IEEE Transactions on Bio-medical Engineering
N Jon Shah, Hans Herzog, Christoph Weirich, Lutz Tellmann, Joachim Kaffanke, Liliana Caldeira, Elena Rota Kops, Syed M Qaim, Heinz H Coenen, Hidehiro Iida
Simultaneous, hybrid MR-PET is expected to improve PET image resolution in the plane perpendicular to the static magnetic field of the scanner. Previous papers have reported this either by simulation or experiment with simple sources and detector arrangements. Here, we extend those studies using a realistic brain phantom in a recently installed MR-PET system comprising a 9.4 T MRI-scanner and an APD-based BrainPET insert in the magnet bore. Point and line sources and a 3D brain phantom were filled with 18F (low-energy positron emitter), 68Ga (medium energy positron emitter) or 120I, a non-standard positron emitter (high positron energies of up to 4...
2014: PloS One
Juan Gallo, Israt S Alam, Jiefu Jin, Yan-Juan Gu, Eric O Aboagye, Wing-Tak Wong, Nicholas J Long
A series of new upconversion nanoparticles have been functionalised with tumour-targeting molecules and metal chelates, prepared following standard peptidic and thiol chemistry. The targeting strategy has been delivered via the αvβ3 integrin, which is a heterodimeric cell surface receptor that is up-regulated in a variety of cancers, such as melanoma and breast cancer. The well-known DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) motif allows coordination to the radionuclide (68)Ga. Radiolabelling experiments were optimised under relatively mild conditions, and are rare amongst nanoparticulate materials...
April 14, 2014: Dalton Transactions: An International Journal of Inorganic Chemistry
André F Martins, M I M Prata, S P J Rodrigues, Carlos F G C Geraldes, P J Riss, A Amor-Coarasa, C Burchardt, C Kroll, F Roesch
Recent reports have claimed a superior performance of HEPES buffer in comparison to alternative buffer systems for (67/68) Ga labeling in aqueous media. In this paper we report spectroscopic ((1) H and (71) Ga NMR), radiochemical, mass spectrometry and theoretical modeling studies on the Ga(3+)/HEPES system (HEPES = N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid) performed with the aim of elucidating a potential contribution of HEPES in the (68/67) Ga radiolabeling process. Our results demonstrate that HEPES acts as a weakly but competitive chelator of Ga(3+) and that this interaction depends on the relative Ga(3+): HEPES concentration...
May 2013: Contrast Media & Molecular Imaging
Kohei Sano, Mayumi Okada, Hayato Hisada, Kenta Shimokawa, Hideo Saji, Minoru Maeda, Takahiro Mukai
On the basis of the findings obtained by X-ray crystallography of Ga-DOTA chelates and the drug design concept of bifunctional radiopharmaceuticals, we previously designed and synthesized a radiogallium-labeled DOTA chelate containing two metronidazole moieties, (67)Ga-DOTA-MN2, for hypoxic tumor imaging. As expected, (67)Ga-DOTA-MN2 exhibited high in vivo stability, although two carboxyl groups in the DOTA skeleton were conjugated with metronidazole moieties. In this study, we evaluated (67/68)Ga-DOTA-MN2 as a nuclear imaging agent for hypoxic tumors...
2013: Biological & Pharmaceutical Bulletin
Karsten J Beiderwellen, Thorsten D Poeppel, Verena Hartung-Knemeyer, Christian Buchbender, Hilmar Kuehl, Andreas Bockisch, Thomas C Lauenstein
OBJECTIVES: The aim of this pilot study was to demonstrate the potential of simultaneously acquired 68-Gallium-DOTA-D-Phe1-Tyr3-octreotide (68Ga-DOTATOC) positron emission tomography/magnetic resonance imaging (PET/MRI) in comparison with 68Ga-DOTATOC PET/computed tomography (PET/CT) in patients with known gastroenteropancreatic neuroendocrine tumors (NETs). MATERIALS AND METHODS: Eight patients (4 women and 4 men; mean [SD] age, 54 [17] years; median, 55 years; range 25-74 years) with histopathologically confirmed NET and scheduled 68Ga-DOTATOC PET/CT were prospectively enrolled for an additional integrated PET/MRI scan...
May 2013: Investigative Radiology
Nikolay Vologdin, Gabriele A Rolla, Mauro Botta, Lorenzo Tei
A heterodimeric polyaminocarboxylate ligand based on a DO3A-sulfonamide linked to AAZTA (6-amino-6-methylperhydro-1,4-diazepinetetracarboxylic acid) was synthesised via an orthogonal pathway in order to differentiate the two chelating cages and allow the formation of a Gd(III)-Ga(III) heteroditopic complex. The goal is to create a smart MRI/PET probe with pH dependent relaxivity and with the bimodal imaging approach that enables direct quantification of the stimulus, in this case pH. A (1)H NMR relaxometric study of the Gd-Ga heteroditopic complex addressed the pH modulation of the relaxivity and thus its possible use as an MRI pH sensitive probe...
February 13, 2013: Organic & Biomolecular Chemistry
Erica Locatelli, Larraitz Gil, Liron Limor Israel, Lorena Passoni, Maria Naddaka, Andrea Pucci, Torsten Reese, Vanessa Gomez-Vallejo, Paolo Milani, Michela Matteoli, Jordi Llop, Jean Paul Lellouche, Mauro Comes Franchini
A novel nanocarrier system was designed and developed with key components uniquely structured at the nanoscale for early cancer diagnosis and treatment. In order to perform magnetic resonance imaging, hydrophilic superparamagnetic maghemite nanoparticles (NPs) were synthesized and coated with a lipophilic organic ligand. Next, they were entrapped into polymeric NPs made of biodegradable poly(lactic-co-glycolic acid) linked to polyethylene glycol. In addition, resulting NPs have been conjugated on their surface with a 2,2'-(7-(4-((2-aminoethyl)amino)-1-carboxy-4-oxobutyl)-1,4,7-triazonane-1,4-diyl)diacetic acid ligand for subsequent (68)Ga incorporation...
2012: International Journal of Nanomedicine
Takeshi Yamada, Yusuke Inoue, Yuji Asano, Yasumasa Nippashi, Reiko Woodhams, Keiji Matsunaga, Masao Tago
OBJECTIVE: Gastric uptake of (67)Ga may be observed in patients with no obvious gastric lesions, as well as those with gastric malignancy. The aim of this study was to investigate whether the use of an effervescent agent aids in evaluating gastric (67)Ga uptake. METHODS: Twenty patients having or suspected of having gastric uptake on whole-body (67)Ga scintigrams were studied. Anterior abdominal images were obtained at baseline and after the oral intake of the effervescent agent (gas contrast image)...
February 2012: Annals of Nuclear Medicine
Eleni Gourni, Oliver Demmer, Margret Schottelius, Calogero D'Alessandria, Stefan Schulz, Ingrid Dijkgraaf, Udo Schumacher, Markus Schwaiger, Horst Kessler, Hans-Jürgen Wester
UNLABELLED: The overexpression of the chemokine receptor CXCR4 plays an important role in oncology, since together with its endogenous ligand, the stromal cell-derived factor (SDF1-α), CXCR4 is involved in tumor development, growth, and organ-specific metastasis. As part of our ongoing efforts to develop highly specific CXCR4-targeted imaging probes and with the aim to assess the suitability of this ligand for first proof-of-concept studies in humans, we further evaluated the new (68)Ga-labeled high-affinity cyclic CXCR4 ligand, (68)Ga-CPCR4-2 (cyclo(D-Tyr(1)-[NMe]-D-Orn(2)-[4-(aminomethyl) benzoic acid,(68)Ga-DOTA]-Arg(3)-2-Nal(4)-Gly(5)))...
November 2011: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Oliver Demmer, Eleni Gourni, Udo Schumacher, Horst Kessler, Hans-Jürgen Wester
No abstract text is available yet for this article.
October 4, 2011: ChemMedChem
Rebecca A Dumont, Friederike Deininger, Roland Haubner, Helmut R Maecke, Wolfgang A Weber, Melpomeni Fani
UNLABELLED: PET with (18)F-labeled arginine-glycine-aspartic acid (RGD) peptides can visualize and quantify α(ν)β(3) integrin expression in patients, but radiolabeling is complex and image contrast is limited in some tumor types. The development of (68)Ga-RGD peptides would be of great utility given the convenience of (68)Ga production and radiolabeling, and (64)Cu-RGD peptides allow for delayed imaging with potentially improved tumor-to-background ratios. METHODS: We used the chelators DOTA,1,4,7-triazacyclononane,1-glutaric acid-4,7-acetic acid (NODAGA), and 4,11-bis(carboxymethyl)-1,4,8,11-tetraazabicyclo[6...
August 2011: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Jae Youn Hwang, Zeev Gross, Harry B Gray, Lali K Medina-Kauwe, Daniel L Farkas
We report a novel in vivo spectral imaging approach to cancer detection and chemotherapy assessment. We describe and characterize a ratiometric spectral imaging and analysis method and evaluate its performance for tumor detection and delineation by quantitatively monitoring the specific accumulation of targeted gallium corrole (HerGa) into HER2-positive (HER2 +) breast tumors. HerGa temporal accumulation in nude mice bearing HER2 + breast tumors was monitored comparatively by a. this new ratiometric imaging and analysis method; b...
June 2011: Journal of Biomedical Optics
Arsénio de Sá, Aurea A Matias, M Isabel M Prata, Carlos F G C Geraldes, P M T Ferreira, João P André
We report a straightforward and efficient synthetic strategy for the synthesis of three model glycine-arginine-glycine-aspartic acid-glycine (GRGDG) conjugates based on derivatives of NOTA and of their Ga(III) complexes targeted to the integrin α(ν)β(3) receptor. (71)Ga NMR spectroscopy showed that the Ga(III)-labeled conjugates are highly stable in aqueous solution. The (67)Ga-labeled conjugates proved to have high kinetic stability and showed a weak but specific binding to the receptors in a U87MG-glioblastoma cell line...
December 15, 2010: Bioorganic & Medicinal Chemistry Letters
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