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https://www.readbyqxmd.com/read/29929212/pharmacological-therapies-for-management-of-opium-withdrawal
#1
REVIEW
Afarin Rahimi-Movaghar, Jaleh Gholami, Laura Amato, Leila Hoseinie, Reza Yousefi-Nooraie, Masoumeh Amin-Esmaeili
BACKGROUND: Pharmacologic therapies for management of heroin withdrawal have been studied and reviewed widely. Opium dependence is generally associated with less severe dependence and milder withdrawal symptoms than heroin. The evidence on withdrawal management of heroin might therefore not be exactly applicable for opium. OBJECTIVES: To assess the effectiveness and safety of various pharmacologic therapies for the management of the acute phase of opium withdrawal...
June 21, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29929182/long-term-evaluation-of-community-health-promotion-using-capacity-building-as-an-intermediate-outcome-measure
#2
S Nickel, W Süß, C Lorentz, A Trojan
OBJECTIVES: Between 2001 and 2012, the health authority of Hamburg-Eimsbüttel carried out a health promotion programme for children and their parents in a disadvantaged neighbourhood called Lenzsiedlung. The programme consisted of different action fields aiming at sustainable establishment of community capacities. STUDY DESIGN: The research goal was the long-term assessment of community capacities with a newly developed instrument 'KEQ' (KEQ = Kapazitätsentwicklung im Quartier/capacity building in small areas/neighbourhoods)...
June 18, 2018: Public Health
https://www.readbyqxmd.com/read/29929173/influence-of-tranexamic-acid-on-cerebral-hemorrhage-a-meta-analysis-of-randomized-controlled-trials
#3
REVIEW
Beilei Huang, Qiusheng Xu, Ru Ye, Jun Xu
Tranexamic acid might be beneficial for cerebral hemorrhage. However, the results remained controversial. We conducted a systematic review and meta-analysis to explore the influence of tranexamic acid on cerebral hemorrhage. PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases were systematically searched. Randomized controlled trials (RCTs) assessing the effect of tranexamic acid on cerebral hemorrhage were included. Two investigators independently searched articles, extracted data, and assessed the quality of included studies...
June 12, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29929086/positive-and-negative-social-support-and-hpa-axis-hyperactivity-evidence-from-glucocorticoids-in-human-hair
#4
Eleonora Iob, Clemens Kirschbaum, Andrew Steptoe
INTRODUCTION: While positive social support is associated with lower prevalence of disease and better treatment outcomes, negative social relationships can instead have unfavourable consequences for several physical and mental health conditions. However, the specific mechanisms by which this nexus might operate remain poorly understood. Hypothalamic-pituitary-adrenal (HPA) axis hyperactivity owing to psychosocial stress has been proposed as a potential pathway underlying the link between social support and health...
June 12, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29929039/combination-of-the-fetal-urinary-metabolome-and-peptidome-for-the-prediction-of-postnatal-renal-outcome-in-fetuses-with-puv
#5
Bénédicte Buffin-Meyer, Julie Klein, Benjamin Breuil, Françoise Muller, Panagiotis Moulos, Marion Groussolles, Ourdia Bouali, Jean-Loup Bascands, Stéphane Decramer, Joost P Schanstra
Most of biomarker panels, extracted from single omics traits, still need improvement since they display a gray zone where prediction is uncertain. Here we verified whether a combination of omics traits, fetal urinary metabolites and peptides analyzed in the same sample, improved prediction of postnatal renal function in fetuses with posterior urethral valves (PUV) compared to individual omics traits. Using CE-MS, we explored the urinary metabolome of 13 PUV fetuses with end stage renal disease (ESRD) and 12 PUV fetuses without postnatal ESRD at 2 years postnatally...
June 18, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29929026/surgical-treatment-of-middle-cerebral-artery-aneurysms-the-aneurysm-location-and-size-ratio-as-risk-factors-for-the-neurological-worsening-and-ischemic-complications
#6
Hidetoshi Matsukawa, Hiroyasu Kamiyama, Takanori Miyazaki, Yu Kinoshita, Nakao Ota, Kosumo Noda, Takaharu Shonai, Osamu Takahashi, Sadahisa Tokuda, Rokuya Tanikawa
OBJECT: Regardless of acceptable surgical results of middle cerebral artery aneurysms (MCAs), MCA territory infarction (MCATI) is still one of major problems needing to be solved to archive the better outcome. Authors aimed to investigate the MCATI in patients with surgically treated MCA aneurysms. METHODS: The data of 286 consecutive patients with 322 MCA aneurysms was retrospectively evaluated. The aneurysm location was classified into the early frontal cortical branch (EFCB), early temporal cortical branch (ETCB), bi- or trifurcation (M1-2), and distal aneurysms on the insular, opercular, or cortical segments of MCA (distal MCA)...
June 18, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29928974/a-bio-guided-approach-for-the-development-of-a-chestnut-based-proanthocyanidin-enriched-nutraceutical-with-potential-anti-gastritis-properties
#7
Enrico Sangiovanni, Stefano Piazza, Urska Vrhovsek, Marco Fumagalli, Saba Khalilpour, Domenico Masuero, Chiara Di Lorenzo, Luca Colombo, Fulvio Mattivi, Emma De Fabiani, Mario Dell'Agli
Gastritis is a widely spread inflammatory disease, mostly caused by Helicobacter pylori infection. Release of IL-8 by the stomach epithelium is a hallmark of gastritis and contributes to the amplification of the inflammatory state. Pharmacological modulation of IL-8 release is a strategy to relieve gastric inflammation and prevent more severe clinical outcomes. In search of nutraceuticals with potential anti-gastritis properties we used a bio-guided approach based on IL-8 secretion by gastric cells to characterize extracts from the fruits of different chestnut varieties...
June 18, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29928936/multiband-fmri-as-a-plausible-time-saving-technique-for-resting-state-data-acquisition-study-on-functional-connectivity-mapping-using-graph-theoretical-measures
#8
K A Smitha, K M Arun, P G Rajesh, Suresh E Joel, Ramesh Venkatesan, Bejoy Thomas, Chandrasekharan Kesavadas
BACKGROUND AND OBJECTIVES: Ensuring patient comfort and compliance by emphasizing reduced time frame for image acquisition, without compromising image quality is the key aspect with functional MRI examination. Multiband resting state fMRI (MB-rsfMRI) is a fairly new technique that potentially shortens MR image acquisition time by providing increased number of time points. The study aims to compare signal characteristics as well as the functional connectivity using conventional resting-state fMRI (rsfMRI) with that of MB-rsfMRI technique...
June 18, 2018: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29928921/paucigranulocytic-asthma-the-uncoupling-of-airway-obstruction-from-inflammation
#9
Omar Tliba, Reynold A Panettieri
Among patients with asthma, heterogeneity exists regarding the pattern of airway inflammation and response to treatment, prompting the necessity of recognizing specific phenotypes. Based on the analysis of inflammatory cell count in induced sputum, patients with asthma can be classified in four unique phenotypes; eosinophilic, neutrophilic, mixed granulocytic, and paucigranulocytic asthma (PGA). PGA is an asthma phenotype with no evidence of elevated numbers of eosinophils or neutrophils in sputum or blood, and in which anti-inflammatory therapies are ineffective in controlling symptoms...
June 18, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29928849/do-antiplatelet-drugs-increase-the-risk-of-bleeding-after-dental-implant-surgery-a-case-and-crossover-study
#10
Reza Tabrizi, Isa Khaheshi, Afshin Hoseinzadeh, Babak Rezvanpour, Shervin Shafee
PURPOSE: Cessation versus continuation of antiplatelet drugs in patients undergoing dental implant surgery is a controversial issue. The present study evaluated postoperative bleeding during and after dental implant surgery in patients taking aspirin (ASA) or clopidogrel. MATERIAL AND METHODS: The present study is a case-and-crossover study. Patients who were using antiplatelet drugs and receiving 2 bilateral dental implants in the posterior region of the mandible were studied...
May 10, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29928834/effectiveness-of-workplace-lactation-interventions-on-breastfeeding-outcomes-in-the-united-states-an-updated-systematic-review
#11
Julia H Kim, Jong C Shin, Sharon M Donovan
Background Returning to work is one of the main barriers to breastfeeding duration among working mothers in the United States. However, the impact of workplace lactation programs is unclear. Research Aim The aim of this study was to evaluate the effectiveness of workplace lactation programs in the United States on breastfeeding practices. Methods A systematic search was conducted of seven databases through September 2017. Articles ( N = 10) meeting the inclusion criteria of describing a workplace lactation intervention and evaluation in the United States and measuring initiation, exclusivity, or duration using an experimental or observational study design were critically evaluated...
June 1, 2018: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/29928832/amalgam-alternatives-cost-effectiveness-and-value-of-information-analysis
#12
F Schwendicke, G Göstemeyer, M Stolpe, J Krois
We aimed to assess the cost-effectiveness of amalgam alternatives-namely, incrementally placed composites (IComp), composites placed in bulk (BComp), and glass ionomer cements (GIC). In a sensitivity analysis, we also included composite inlays (CompI) and incrementally placed bulk-fills (IBComp). Moreover, the value of information (VOI) regarding the effectiveness of all strategies was determined. A mixed public-private-payer perspective in the context of Germany was adopted. Bayesian network meta-analyses were performed to yield effectiveness estimates (relative risk [RR] of failure)...
June 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29928762/effect-of-choline-supplementation-on-neurological-cognitive-and-behavioral-outcomes-in-offspring-arising-from-alcohol-exposure-during-development-a-quantitative-systematic-review-of-clinical-and-preclinical-studies
#13
Lisa K Akison, Jenny Kuo, Natasha Reid, Roslyn N Boyd, Karen M Moritz
Prenatal alcohol exposure results in cognitive, behavioral and neurological deficits in offspring. There is an urgent need for safe and effective treatments to overcome these effects. Maternal choline supplementation has been identified as a potential intervention. Our objective was to review preclinical and clinical studies using choline supplementation in known cases of fetal alcohol exposure to determine its effectiveness in ameliorating deficits in offspring. A systematic search of six electronic databases was conducted and studies selected by reviewing titles/abstracts against specific inclusion/exclusion criteria...
June 21, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29928702/phase-i-and-ii-trial-on-infusional-5-fluorouracil-and-gefitinib-in-combination-with-preoperative-radiotherapy-in-rectal-cancer-10-years-median-follow-up
#14
Maria Antonietta Gambacorta, Antonino De Paoli, Marco Lupattelli, Giuditta Chiloiro, Angela Pia Solazzo, Brunella Barbaro, Sergio Alfieri, Fabio Maria Vecchio, Jacopo Lenkowicz, Francesco Navarria, Elisa Palazzari, Giulio Bertola, Alessandro Frattegiani, Bruce Minsky, Vincenzo Valentini
Purpose: The aim of this study is to evaluate the long term survival of the addition of gefitinib to chemoradiotherapy (CRT) in locally advanced rectal cancer (LARC). Methods and materials: This previously published multicentre, open-label, phase I-II study, enrolled patients (pts) with LARC to receive CRT with concurrent 5-fluorouracil continuous intravenous infusion and a dose escalation of orally administered gefitinib, followed 6-8 weeks later by surgery. An intra-operative radiotherapy boost of 10 Gy was planned...
March 2018: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29928687/nationwide-real-world-database-of-20-462-patients-enrolled-in-the-japanese-acute-myocardial-infarction-registry-jamir-impact-of-emergency-coronary-intervention-in-a-super-aging-population
#15
Sunao Kojima, Kensaku Nishihira, Misa Takegami, Yoko M Nakao, Satoshi Honda, Jun Takahashi, Morimasa Takayama, Hiroaki Shimokawa, Tetsuya Sumiyoshi, Hisao Ogawa, Kazuo Kimura, Satoshi Yasuda
Background: Cardiovascular diseases, including acute myocardial infarction (AMI), are leading causes of death among the Japanese, who have the longest life expectancy in the world. Over the past 50 years in Japan, the percentage of elderly individuals has increased 4-fold, from 5.7% in 1960 to 23.1% in 2010. To explore medical practices and emergency care for AMI in this aging society, the Japan Acute Myocardial Infarction Registry (JAMIR) was established as a nationwide real-world database...
September 2018: IJC Heart & Vasculature
https://www.readbyqxmd.com/read/29928656/long-term-phase-1-2-intraspinal-stem-cell-transplantation-outcomes-in-als
#16
Stephen A Goutman, Morton B Brown, Jonathan D Glass, Nicholas M Boulis, Karl Johe, Tom Hazel, Merit Cudkowicz, Nazem Atassi, Lawrence Borges, Parag G Patil, Stacey A Sakowski, Eva L Feldman
Objective: Intraspinal human spinal cord-derived neural stem cell (HSSC) transplantation is a potential therapy for amyotrophic lateral sclerosis (ALS); however, previous trials lack controls. This post hoc analysis compared ambulatory limb-onset ALS participants in Phase 1 and 2 (Ph1/2) open-label intraspinal HSSC transplantation studies up to 3 years after transplant to matched participants in Pooled Resource Open-Access ALS Clinical Trials (PRO-ACT) and ceftriaxone datasets to provide required analyses to inform future clinical trial designs...
June 2018: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29928650/the-nrf2-pathway-as-potential-biomarker-for-dimethyl-fumarate-treatment-in-multiple-sclerosis
#17
Anna Hammer, Anne Waschbisch, Kristina Kuhbandner, Antonios Bayas, De-Hyung Lee, Alexander Duscha, Aiden Haghikia, Ralf Gold, Ralf A Linker
Objective: Immunological studies have demonstrated a plethora of beneficial effects of dimethyl fumarate (DMF) on various cell types. However, the cellular and molecular targets are incompletely understood and response markers are scarce. Here, we focus on the relation between nuclear factor (erythroid-derived 2)-like 2 (NRF2) pathway induction under DMF therapy and the composition of the blood immune cell compartment and clinical efficacy in relapsing-remitting multiple sclerosis (MS) patients...
June 2018: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29928607/risk-factors-for-poor-outcome-in-posterior-reversible-encephalopathy-syndrome-systematic-review-and-meta-analysis
#18
Zheng Chen, Gang Zhang, Alexander Lerner, An-Hui Wang, Bo Gao, Jie Liu
Background: The roles of clinical etiology and symptoms, imaging findings and biochemical parameters in predicting the prognosis of posterior reversible encephalopathy syndrome (PRES) have not been well-characterized. We perform a meta-analysis of all published studies to assess the value of various risk factors in predicting the prognosis of PRES. Methods: Searches of the PubMed, EMBASE, Cochrane Library, and Web of Science databases were performed to identify the eligible studies...
May 2018: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29928605/hemodynamic-analysis-of-carotid-artery-after-endarterectomy-a-preliminary-and-quantitative-imaging-study-based-on-computational-fluid-dynamics-and-magnetic-resonance-angiography
#19
Yuanyuan Dai, Peng Lv, Ashkan Javadzadegan, Xiao Tang, Yi Qian, Jiang Lin
Background: The carotid blood flow following carotid endarterectomy (CEA) is not fully understood. Computational fluid dynamics (CFD) is a promising method to study blood flow. This study is to investigate local hemodynamic characteristics after CEA via the use of unenhanced magnetic resonance angiography (MRA) and CFD. Methods: Eight carotid arteries with atherosclerosis and sixteen normal carotid arteries were included in this study. Time-of-flight (TOF) and phase contrast (PC) MRA were applied for the measurement of three-dimensional artery geometries and velocity profile under CFD simulation...
May 2018: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29928480/integrated-epigenetic-and-genetic-analysis-identifies-markers-of-prognostic-significance-in-pediatric-acute-myeloid-leukemia
#20
Jatinder K Lamba, Xueyuan Cao, Susana C Raimondi, Roya Rafiee, James R Downing, Shi Lei, Tanja Gruber, Raul C Ribeiro, Jeffrey E Rubnitz, Stanley B Pounds
Acute myeloid leukemia (AML) may be an epigenetically-driven malignancy because it harbors fewer genomic mutations than other cancers. In recent studies of AML in adults, DNA methylation patterns associate with clinical risk groups and prognosis. However, thorough evaluations of methylation in pediatric AML have not been done. Therefore, we performed an integrated analysis (IA) of the methylome and transcriptome with clinical outcome in 151 pediatric patients from the multi-center AML02 clinical trial discovery cohort...
June 1, 2018: Oncotarget
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