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https://www.readbyqxmd.com/read/28918275/the-association-between-ambient-temperature-and-the-risk-of-preterm-birth-in-china
#1
Tongjun Guo, Yuanyuan Wang, Hongguang Zhang, Ya Zhang, Jun Zhao, Yan Wang, Xiaoxu Xie, Long Wang, Qian Zhang, Dujia Liu, Yuan He, Ying Yang, Jihong Xu, Zuoqi Peng, Xu Ma
BACKGROUND: With the gradual increase of global warming, the impact of extreme temperatures on health has become a focus of attention, however, its relationship with preterm birth remains unclear. OBJECTIVES: To investigate the association between exposure to extreme temperatures and preterm birth. METHODS: Temperature exposures and birth outcomes of 1,020,471 pregnant women from 132 cities in China were investigated. The pregnancy process was divided into different pregnancy periods...
September 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28913410/contrast-microsphere-enhancement-of-the-tricuspid-regurgitant-spectral-doppler-signal-is-it-still-necessary-with-contemporary-scanners
#2
David G Platts, Manan Vaishnav, Darryl J Burstow, Christian Hamilton Craig, Jonathan Chan, John L Sedgwick, Gregory M Scalia
BACKGROUND: Accurate evaluation of the tricuspid regurgitant (TR) spectral Doppler signal is important during transthoracic echocardiographic (TTE) evaluation for pulmonary hypertension (PHT). Contrast enhancement improves Doppler backscatter. However, its incremental benefit with contemporary scanners is less well established. The aim of this study was to assess whether the TR spectral Doppler signal using contemporary scanners was improved using a second generation contrast agent, Definity® (CE), compared to unenhanced TTE (UE)...
December 2017: IJC Heart & Vasculature
https://www.readbyqxmd.com/read/28912636/should-emergency-endoscopy-be-performed-in-all-patients-with-suspected-colonic-diverticular-hemorrhage
#3
Takeshi Uehara, Satohiro Matsumoto, Hiroyuki Miyatani, Hirosato Mashima
OBJECTIVE: We attempted to develop a scoring system for facilitating decision making regarding the performance of emergency endoscopy in patients with colonic diverticular hemorrhage. METHODS: This study involved analysis of the data of 178 patients who presented with hematochezia and were diagnosed as having colonic diverticular hemorrhage by colonoscopy. The patients were divided into 2 groups depending on whether the bleeding source was identified or not at the initial endoscopy (source-identified and source-not-identified groups), and on the basis of the results obtained, we established a scoring system for predicting successful identification of the bleeding source...
2017: Clinical Medicine Insights. Gastroenterology
https://www.readbyqxmd.com/read/28912555/new-taxa-of-freshwater-mussels-unionidae-from-a-species-rich-but-overlooked-evolutionary-hotspot-in-southeast-asia
#4
Ivan N Bolotov, Ilya V Vikhrev, Alexander V Kondakov, Ekaterina S Konopleva, Mikhail Yu Gofarov, Olga V Aksenova, Sakboworn Tumpeesuwan
Southeast Asia harbors a unique and diverse freshwater fauna of Mesozoic origin, which is under severe threat of extinction because of rapid economic development and urbanization. The largest freshwater basins of the region are certainly the primary evolutionary hotspots and they attract the most attention as key biodiversity areas for conservation. In contrast, medium-sized rivers are considered low-importance areas with secondary biodiversity, whose faunas originated via founder events from larger basins during the Pleistocene, although such a scenario has never been tested by using a phylogenetic approach...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28912375/organ-culture-of-the-xenopus-tadpole-intestine
#5
Atsuko Ishizuya-Oka
During Xenopus metamorphosis, most tadpole organs remodel from the larval to adult form to prepare for adaptation to terrestrial life. Organ culture serves as an important tool for studying larval-to-adult organ remodeling independent of the effects of other parts of the body. Here, I introduce a protocol for organ culture in vitro using the Xenopus laevis tadpole intestine before metamorphic climax. During culture in the absence of exogenous 3,3',5-triiodo-l-thyronine (T3), the most potent natural thyroid hormone, the intestine remains in its larval state without any metamorphic changes...
September 14, 2017: Cold Spring Harbor Protocols
https://www.readbyqxmd.com/read/28910408/effects-of-tumour-necrosis-factor-%C3%AE-upon-the-metabolism-of-the-endocannabinoid-anandamide-in-prostate-cancer-cells
#6
Jessica Karlsson, Sandra Gouveia-Figueira, Mireille Alhouayek, Christopher J Fowler
Tumour necrosis factor α (TNFα) is involved in the pathogenesis of prostate cancer, a disease where disturbances in the endocannabinoid system are seen. In the present study we have investigated whether treatment of DU145 human prostate cancer cells affects anandamide (AEA) catabolic pathways. Additionally, we have investigated whether cyclooxygenase-2 (COX-2) can regulate the uptake of AEA into cells. Levels of AEA synthetic and catabolic enzymes were determined by qPCR. AEA uptake and hydrolysis in DU145 and RAW264...
2017: PloS One
https://www.readbyqxmd.com/read/28906373/predictive-value-of-insufficient-contrast-medium-filling-in-pulmonary-veins-in-patients-with-acute-pulmonary-embolism
#7
Hong Zhang, Yanhe Ma, Zhenchun Song, Jun Lv, Yapeng Yang
This study is to investigate the predictive value of insufficient contrast medium filling (ICMF) in patients with acute pulmonary embolism (PE).A total of 108 PE patients were enrolled and divided into group A and group B according to the presence of ICMF. PE index and ventricul araxial lengths were measured. Heart cavity volumes were examined and right ventricle (RV) to left ventricle (LV) diameter ratio (RV/LV(d)) and volume ratio (RV/LV(V)) and right atrium (RA) to left atrium (LA) volume ratio (RA/LA(V)) were calculated and compared...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28901491/mir%C3%A2-21-attenuates-contrast%C3%A2-induced-renal-cell-apoptosis-by-targeting-pdcd4
#8
Kun Wang, Wei-Jie Bei, Yuan-Hui Liu, Hua-Long Li, Shi-Qun Chen, Kai-Yang Lin, Zhi-Ling Zhou, Ji-Yan Chen, Yong Liu, Ning Tan
Contrast medium (CM) is widely used in cardiac catheterization; however, it may induce acute kidney injury or renal failure, although the underlying mechanism remains to be elucidated. MicroRNA‑21 (miR‑21) is involved in renal disease and has been indicated to regulate cellular apoptosis and fibrosis, although its role in CM‑induced renal cell injury is unknown. The present study examined the expression and potential targets of miR‑21 in human renal proximal tubular epithelial (HK‑2) cells following CM treatment...
September 5, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28900020/petrobactin-is-exported-from-bacillus-anthracis-by-the-rnd-type-exporter-apex
#9
A K Hagan, A Tripathi, D Berger, D H Sherman, P C Hanna
Bacillus anthracis-a Gram-positive, spore-forming bacterium-causes anthrax, a highly lethal disease with high bacteremia titers. Such rapid growth requires ample access to nutrients, including iron. However, access to this critical metal is heavily restricted in mammals, which requires B. anthracis to employ petrobactin, an iron-scavenging small molecule known as a siderophore. Petrobactin biosynthesis is mediated by asb gene products, and import of the iron-bound (holo)-siderophore into the bacterium has been well studied...
September 12, 2017: MBio
https://www.readbyqxmd.com/read/28899867/epidural-interlaminar-injections-in-severe-degenerative-lumbar-spine-fluoroscopy-should-not-be-a-luxury
#10
Dimitrios K Filippiadis, Thomas Rodt, Maria-Chrysanthi Kitsou, Chrysanthi Batistaki, Nikolaos Kelekis, Georgia Kostopanagiotou, Alexis Kelekis
OBJECTIVE: To assess technical efficacy, accuracy, and safety of epidural (interlaminar) injections performed blindly in patients with a severely degenerated lumbar spine. METHODS: Over 12 consecutive months, 138 patients with a severe degenerative lumbar spine underwent epidural (interlaminar) injection as therapy for low back pain and neuralgia. Patients had already undergone a blind epidural infiltration with minimum or no pain reduction. The session was repeated in the angiography suite...
September 12, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/28899855/a-simple-method-of-measuring-the-wear-of-explanted-acetabular-component-inserts
#11
L Krakow, A Klockow, E Roehner, S Brodt, H Eijer, J Bossert, G Matziolis
AIMS: The determination of the volumetric polyethylene wear on explanted material requires complicated equipment, which is not available in many research institutions. Our aim in this study was to present and validate a method that only requires a set of polyetheretherketone balls and a laboratory balance to determine wear. METHODS: The insert to be measured was placed on a balance, and a ball of the appropriate diameter was inserted. The cavity remaining between the ball and insert caused by wear was filled with contrast medium and the weight of the contrast medium was recorded...
September 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28894439/phenotypic-changes-exhibited-by-e-coli-cultured-in-space
#12
Luis Zea, Michael Larsen, Frederico Estante, Klaus Qvortrup, Ralf Moeller, Sílvia Dias de Oliveira, Louis Stodieck, David Klaus
Bacteria will accompany humans in our exploration of space, making it of importance to study their adaptation to the microgravity environment. To investigate potential phenotypic changes for bacteria grown in space, Escherichia coli was cultured onboard the International Space Station with matched controls on Earth. Samples were challenged with different concentrations of gentamicin sulfate to study the role of drug concentration on the dependent variables in the space environment. Analyses included assessments of final cell count, cell size, cell envelope thickness, cell ultrastructure, and culture morphology...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28893793/chemical-genomic-interaction-profiling-reveals-determinants-of-intrinsic-antibiotic-resistance-in-mycobacterium-tuberculosis
#13
Weizhen Xu, Michael A DeJesus, Nadine Rücker, Curtis A Engelhart, Meredith G Wright, Claire Healy, Kan Lin, Ruojun Wang, Sae Woong Park, Thomas R Ioerger, Dirk Schnappinger, Sabine Ehrt
Chemotherapy for tuberculosis (TB) is lengthy and could benefit from synergistic adjuvant therapeutics that enhance current and novel drug regimens. To identify genetic determinants of intrinsic antibiotic susceptibility in Mycobacterium tuberculosis (Mtb) we applied a chemical genetic interaction (CGI) profiling approach. We screened a saturated transposon mutant library and identified mutants that exhibit altered fitness in the presence of partially-inhibitory concentrations of rifampicin, ethambutol, isoniazid, vancomycin and meropenem, antibiotics of diverse mechanisms-of-action...
September 11, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28890078/choroidal-thinning-associated-with-hydroxychloroquine-retinopathy
#14
Seong Joon Ahn, So Jung Ryu, Joo Young Joung, Byung Ro Lee
PURPOSE: To investigate choroidal thickness in patients using hydroxychloroquine (HCQ) and compare choroidal thickness between eyes with and without HCQ retinopathy. DESIGN: Retrospective case series METHODS: Setting: Institutional Patients: We included 124 patients with systemic lupus erythematosus or rheumatoid arthritis who were treated with HCQ. The patients were divided into an HCQ retinopathy group and a control group, according to the presence or absence of HCQ retinopathy...
September 7, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28880116/photoacoustic-imaging-for-noninvasive-periodontal-probing-depth-measurements
#15
C Y Lin, F Chen, A Hariri, C J Chen, P Wilder-Smith, T Takesh, J V Jokerst
The periodontal probe is the gold standard tool for periodontal examinations, including probing depth measurements, but is limited by systematic and random errors. Here, we used photoacoustic ultrasound for high-spatial resolution imaging of probing depths. Specific contrast from dental pockets was achieved with food-grade cuttlefish ink as a contrast medium. Here, 39 porcine teeth (12 teeth with artificially deeper pockets) were treated with the contrast agent, and the probing depths were measured with novel photoacoustic imaging and a Williams periodontal probe...
September 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28878689/a20-tnfaip3-discriminates-tumor-necrosis-factor-tnf-induced-nf-%C3%AE%C2%BAb-from-jnk-pathway-activation-in-hepatocytes
#16
Federico Pinna, Michaela Bissinger, Katharina Beuke, Nicolas Huber, Thomas Longerich, Ursula Kummer, Peter Schirmacher, Sven Sahle, Kai Breuhahn
In the liver tumor necrosis factor (TNF)-induced signaling critically regulates the immune response of non-parenchymal cells as well as proliferation and apoptosis of hepatocytes via activation of the NF-κB and JNK pathways. Especially, the induction of negative feedback regulators, such as IκBα and A20 is responsible for the dynamic and time-restricted response of these important pathways. However, the precise mechanisms responsible for different TNF-induced phenotypes under physiological stimulation conditions are not completely understood so far...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28876979/general-anaesthesia-for-patients-with-a-history-of-a-contrast-medium-induced-anaphylaxis-a-useful-prophylaxis
#17
Ingrid Boehm, Knud Nairz, John Morelli, Patricia Silva Hasembank Keller, Johannes Thomas Heverhagen
Contrast-enhanced radiological examinations are important diagnostic tools in modern medicine. Currently, all approved and available iodinated and gadolinium-based contrast agents are safe and well tolerated by most patients. However, approximately 2% of patients receiving iodinated contrast media (CM) exhibit hypersensitivity reactions. Patients with a history of such a reaction are at increased risk upon re-exposure. Therefore, they are subjected to a prophylaxis such as injection of anti-allergy drugs or general anesthesia...
September 6, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28876364/silencing-of-augmenter-of-liver-regeneration-inhibited-cell-proliferation-and-triggered-apoptosis-in-u266-human-multiple-myeloma-cells
#18
H Q Zeng, Y Luo, S F Lou, Q Liu, L Zhang, J C Deng
Augmenter of liver regeneration (ALR) is a thermostable cytokine that was originally identified to promote the growth of hepatocytes. This study was conducted to explore the expression and function of ALR in multiple myeloma (MM), a common hematologic malignancy. Real-time PCR and western blot analysis were performed to detect the expression of ALR in U266 human MM cells and healthy peripheral blood mononuclear cells (PBMCs). U266 MM cells were exposed to 20 or 40 μg/mL of recombinant ALR and tested for cell proliferation...
August 31, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28875326/neuroradiologic-characteristics-of-primary-angiitis-of-the-central-nervous-system-according-to-the-affected-vessel-size
#19
Christian Thaler, Ann-Katrin Kaufmann-Bühler, Tserenchunt Gansukh, Amarjargal Gansukh, Simon Schuster, Henrike Bachmann, Götz Thomalla, Tim Magnus, Jakob Matschke, Jens Fiehler, Susanne Siemonsen
INTRODUCTION: Magnetic resonance imaging (MRI) has an important impact in diagnosing primary angiitis of the central nervous system (PACNS). However, neuroradiologic findings may vary immensely, making an easy and definite diagnosis challenging. METHODS: In this retrospective, single center study, we analyzed neuroradiologic findings of patients with PACNS diagnosed at our hospital between 2009 and 2014. Furthermore, we classified patients according to the affected vessel size and compared imaging characteristics between the subgroups...
September 5, 2017: Clinical Neuroradiology
https://www.readbyqxmd.com/read/28875027/viscous-hydrophilic-injection-matrices-for-serial-crystallography
#20
Gabriela Kovácsová, Marie Luise Grünbein, Marco Kloos, Thomas R M Barends, Ramona Schlesinger, Joachim Heberle, Wolfgang Kabsch, Robert L Shoeman, R Bruce Doak, Ilme Schlichting
Serial (femtosecond) crystallography at synchrotron and X-ray free-electron laser (XFEL) sources distributes the absorbed radiation dose over all crystals used for data collection and therefore allows measurement of radiation damage prone systems, including the use of microcrystals for room-temperature measurements. Serial crystallography relies on fast and efficient exchange of crystals upon X-ray exposure, which can be achieved using a variety of methods, including various injection techniques. The latter vary significantly in their flow rates - gas dynamic virtual nozzle based injectors provide very thin fast-flowing jets, whereas high-viscosity extrusion injectors produce much thicker streams with flow rates two to three orders of magnitude lower...
July 1, 2017: IUCrJ
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