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https://www.readbyqxmd.com/read/29777576/glioblastoma-recurrence-correlates-with-nlgn3-levels
#1
Rui Liu, Xing-Ping Qin, Yang Zhuang, Ya Zhang, Hua-Bao Liao, Jun-Chun Tang, Meng-Xian Pan, Fei-Fei Zeng, Yang Lei, Rui-Xue Lei, Shu Wang, An-Chun Liu, Juan Chen, Zhi-Feng Zhang, Dan Zhao, Song-Lin Wu, Ren-Zhong Liu, Ze-Fen Wang, Qi Wan
Glioblastoma (GBM) is the most aggressive glioma in the brain. Recurrence of GBM is almost inevitable within a short term after tumor resection. In a retrospective study of 386 cases of GBM collected between 2013 and 2016, we found that recurrence of GBM mainly occurs in the deep brain regions, including the basal ganglia, thalamus, and corpus callosum. But the mechanism underlying this phenomenon is not clear. Previous studies suggest that neuroligin-3 (NLGN3) is necessary for GBM growth. Our results show that the levels of NLGN3 in the cortex are higher than those in the deep regions in a normal human brain, and similar patterns are also found in a normal mouse brain...
May 18, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29777389/iron-based-metal-organic-frameworks-as-a-theranostic-carrier-for-local-tuberculosis-therapy
#2
Gabriela Wyszogrodzka, Przemysław Dorożyński, Barbara Gil, Wieslaw J Roth, Maciej Strzempek, Bartosz Marszałek, Władysław P Węglarz, Elżbieta Menaszek, Weronika Strzempek, Piotr Kulinowski
PURPOSE: The purpose of the study was initial evaluation of applicability of metal organic framework (MOF) Fe-MIL-101-NH2 as a theranostic carrier of antituberculous drug in terms of its functionality, i.e. drug loading, drug dissolution, magnetic resonance imaging (MRI) contrast and cytotoxic safety. METHODS: Fe-MIL-101-NH2 was characterized using X-ray powder diffraction, FTIR spectrometry and scanning electron microscopy. The particle size analysis was determined using laser diffraction...
May 18, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29776437/coenzyme-q10-combined-with-trimetazidine-in-the-prevention-of-contrast-induced-nephropathy-in-patients-with-coronary-heart-disease-complicated-with-renal-dysfunction-undergoing-elective-cardiac-catheterization-a-randomized-control-study-and-in-vivo-study
#3
Fei Chen, Fan Liu, Jingchao Lu, Xiuchun Yang, Bing Xiao, Yaqiong Jin, Jie Zhang
BACKGROUND: Contrast-induced nephropathy (CIN) is one of the common hospital-acquired acute renal failures. The purpose of this study was to investigate whether Coenzyme Q10 (CoQ10) and trimetazidine (TMZ) can prevent the occurrence of CIN after elective cardiac catheterization in patients with coronary artery disease complicated with renal dysfunction. METHODS: Consecutive coronary artery disease patients with renal insufficiency scheduled for coronary angiography were enrolled in randomized, paralleled, double-blind, controlled trial...
May 18, 2018: European Journal of Medical Research
https://www.readbyqxmd.com/read/29775920/il-33-stimulates-expression-of-the-gpr84-ex33-fatty-acid-receptor-gene-and-of-cytokine-and-chemokine-genes-in-human-adipocytes
#4
Mohamed S Zaibi, Małgorzata A Kępczyńska, Parvathy Harikumar, Suliman Y Alomar, Paul Trayhurn
Expression of GPCR fatty acid sensor/receptor genes in adipocytes is modulated by inflammatory mediators, particularly IL-1β. In this study we examined whether the IL-1 gene superfamily member, IL-33, also regulates expression of the fatty acid receptor genes in adipocytes. Human fat cells, differentiated from preadipocytes, were incubated with IL-33 at three different dose levels for 3 or 24 h and mRNA measured by qPCR. Treatment with IL-33 induced a dose-dependent increase in GPR84 mRNA at 3 h, the level with the highest dose being 13...
May 15, 2018: Cytokine
https://www.readbyqxmd.com/read/29774356/size-dependent-penetrant-diffusion-in-polymer-glasses
#5
Dong Meng, Kai Zhang, Sanat K Kumar
Molecular Dynamics simulations are used to understand the underpinning basis of the transport of gas-like solutes in deeply quenched polymeric glasses. As found in previous work, small solutes, with sizes smaller than 0.15 times the chain monomer size, move as might be expected in a medium with large pores. In contrast, the motion of larger solutes is activated and is strongly facilitated by matrix motion. In particular, solute motion is coupled to the local elastic fluctuations of the matrix as characterized by the Debye-Waller factor...
May 18, 2018: Soft Matter
https://www.readbyqxmd.com/read/29773134/developmental-capacity-of-ascaridia-galli-eggs-is-preserved-after-anaerobic-storage-in-faeces
#6
B Tarbiat, S Rahimian, D S Jansson, P Halvarsson, J Höglund
The reliability of the results of in vitro studies such as detection of anthelmintic resistance often depends on the ability of the parasite eggs to develop under laboratory conditions. The aim of this study was to assess the embryonation capability of the chicken roundworm Ascaridia galli eggs after storage under different conditions. Two storage media for parasite eggs were used; faeces or water. Eggs in petri dishes (90 dishes in total) containing faces or water media were first exposed either to aerobic or anaerobic conditions at different temperatures (4 °C /+O2 , 4 °C /-O2 , 25 °C/-O2 ) for a maximum of 72 days...
May 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29771999/growth-medium-dependent-antimicrobial-activity-of-early-stage-mep-pathway-inhibitors
#7
Sara Sanders, David Bartee, Mackenzie J Harrison, Paul D Phillips, Andrew T Koppisch, Caren L Freel Meyers
The in vivo microenvironment of bacterial pathogens is often characterized by nutrient limitation. Consequently, conventional rich in vitro culture conditions used widely to evaluate antibacterial agents are often poorly predictive of in vivo activity, especially for agents targeting metabolic pathways. In one such pathway, the methylerythritol phosphate (MEP) pathway, which is essential for production of isoprenoids in bacterial pathogens, relatively little is known about the influence of growth environment on antibacterial properties of inhibitors targeting enzymes in this pathway...
2018: PloS One
https://www.readbyqxmd.com/read/29770864/agrobacterium-mediated-transformation-of-yeast-and-fungi
#8
Paul J J Hooykaas, G Paul H van Heusden, Xiaolei Niu, M Reza Roushan, Jalal Soltani, Xiaorong Zhang, Bert J van der Zaal
Two decades ago, it was discovered that the well-known plant vector Agrobacterium tumefaciens can also transform yeasts and fungi when these microorganisms are co-cultivated on a solid substrate in the presence of a phenolic inducer such as acetosyringone. It is important that the medium has a low pH (5-6) and that the temperature is kept at room temperature (20-25 °C) during co-cultivation. Nowadays, Agrobacterium-mediated transformation (AMT) is the method of choice for the transformation of many fungal species; as the method is simple, the transformation efficiencies are much higher than with other methods, and AMT leads to single-copy integration much more frequently than do other methods...
May 17, 2018: Current Topics in Microbiology and Immunology
https://www.readbyqxmd.com/read/29768921/polyoxotungstate-carbon-nanocomposites-as-oxygen-reduction-reaction-orr-electrocatalysts
#9
Diana Mesquita Fernandes, Hugo C Novais, Revathi R Bacsa, Philippe Serp, Belén Bachiller-Baeza, Inmaculada Rodriguez-Ramos, Antonio Guerrero-Ruiz, Cristina Freire
The oxygen reduction reaction (ORR) has a crucial function as the cathode reaction in energy-converting systems, such as fuel cells (FCs), which contributes to a sustainable energy supply. However, the current use of precious Pt-based electrocatalysts (ECs) is a major drawback for the economic viability of fuel cells. Hence, it is urgent to develop cost-effective and efficient electrocatalysts (ECs) without noble metals to substitute the Pt-based ECs. Herein, we report the preparation and application as ORR electrocatalysts of four new nanocomposites based on sandwich-type phosphotungstate [(TBA)7H3[Co4(H2O)2(PW9O34)2] (TBA-Co4(PW9)2) immobilized onto different carbon nanomaterials (single-walled carbon nanotubes (SWCNT), graphene flakes (GF), carbon nanotubes doped with nitrogen (N-CNT) and nitrogen-doped few layer graphene (N-FLG))...
May 16, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29767946/highly-stable-graphene-based-nanocomposite-go-pei-ag-with-broad-spectrum-long-term-antimicrobial-activity-and-antibiofilm-effects
#10
Rongtao Zhao, Wen Kong, Mingxuan Sun, Yi Yang, Wanying Liu, Min Lv, Shiping Song, Lihua Wang, Hongbin Song, Rongzhang Hao
Various silver nanoparticle (AgNP)-decorated graphene oxide (GO) nanocomposites (GO-Ag) have received increasing attention owing to their antimicrobial activity and biocompatibility; however, their aggregation in physiological solutions and the generally complex synthesis methods warrant improvement. This study aimed to synthesize a polyethyleneimine (PEI)-modified and AgNP-decorated GO nanocomposite (GO-PEI-Ag) through a facile approach through microwave irradiation without any extra reductants and surfactants; its antimicrobial activity was investigated on Gram-negative/-positive bacteria (including drug-resistant bacteria) and fungi...
May 16, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29767384/understanding-physical-activity-through-interactions-between-the-built-environment-and-social-cognition-a-systematic-review
#11
REVIEW
Ryan E Rhodes, Brian E Saelens, Claire Sauvage-Mar
BACKGROUND: Few people in most developed nations engage in regular physical activity (PA), despite its well-established health benefits. Socioecological models highlight the potential interaction of multiple factors from policy and the built environment to individual social cognition in explaining PA. OBJECTIVE: The purpose of this review was to appraise this interaction tenet of the socioecological model between the built environment and social cognition to predict PA...
May 16, 2018: Sports Medicine
https://www.readbyqxmd.com/read/29766914/training-residents-and-fellows-in-the-procedure-of-diagnostic-cervicocerebral-angiography-techniques-to-avoid-complications
#12
Xianli Lv, Wei Li, Youxiang Li
We examine the problems arising when training residents/fellows (RFs) initiate the learning of diagnostic cervicocerebral angiography (DCCA) and describe the steps on how to facilitate the learning process while avoiding complications. The risk of permanent neurological deficit as a result of DCCA ranges from 0.3-0.5%. Factors that correlated with complications include the following: the history of cerebral infarction, infusion of a large amount of contrast medium, a prolonged fluoroscopic time (>80 min) and the efficiency of training received...
May 2018: Neurology India
https://www.readbyqxmd.com/read/29765622/are-monkeys-intuitive-aristotelians-associations-between-target-size-and-vertical-target-position-in-long-tailed-macaques
#13
Stefanie Keupp, Natàlia Barbarroja, Sascha Topolinski, Julia Fischer
Different hypotheses have been put forward to explain the interaction between size perception and spatial position. To explore the evolutionary roots of these phenomena, we tested long-tailed macaques' performance in a two-choice discrimination task on a touchscreen and contrasted two hypotheses. First, a hierarchy association in which large objects are associated with top positions, due to a link between power, dominance and importance with top position. Second, a naive Aristotelian association in which large objects are associated with bottom positions, due to the experience that larger objects are heavier and thus more likely to be found at the bottom...
April 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29757718/us-of-right-upper-quadrant-pain-in-the-emergency-department-diagnosing-beyond-gallbladder-and-biliary-disease
#14
Gayatri Joshi, Kevin A Crawford, Tarek N Hanna, Keith D Herr, Nirvikar Dahiya, Christine O Menias
Acute cholecystitis is the most common diagnosable cause for right upper quadrant abdominal (RUQ) pain in patients who present to the emergency department (ED). However, over one-third of patients initially thought to have acute cholecystitis actually have RUQ pain attributable to other causes. Ultrasonography (US) is the primary imaging modality of choice for initial imaging assessment and serves as a fast, cost-effective, and dynamic modality to provide a definitive diagnosis or a considerably narrowed list of differential possibilities...
May 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29756658/loop-length-affects-syn-anti-conformational-rearrangements-in-parallel-g-quadruplexes
#15
Beatrice Karg, Klaus Weisz
A G-quadruplex forming sequence from the MYC promoter region was modified with syn-favoring 8-bromo-2'-deoxyguanosine residues. Depending on the number and position of modifications in the intramolecular parallel G-quadruplex, substitutions with the bromoguanosine analog at the 5'-tetrad induce conformational rearrangements with concerted all-anti to all-syn transitions for all residues of the modified G-quartet. No unfavorable steric interactions of the C8-substituents in the medium grooves are apparent in the high-resolution structure as determined for a tetrasubstituted MYC quadruplex that exclusively forms the all-syn isomer...
May 14, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29755714/identification-of-cerebral-artery-stenosis-using-bilateral-photoplethysmography
#16
Hyun Goo Kang, Seogki Lee, Han Uk Ryu, Youngsuk Shin
Cerebral artery stenosis is currently diagnosed by transcranial Doppler (TCD), computed tomographic angiography (CTA), or magnetic resonance angiography (MRA). CTA exposes a patient to radiation, while CTA and MRA are invasive and side effects were related to contrast medium use. This study aims to provide a technique that can simply discriminate between people with normal blood vessels and those with cerebral artery stenosis using photoplethysmography (PPG), which is noninvasive and inexpensive. Moreover, the measurement takes only 120 seconds and is conducted on the fingers...
2018: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29755685/selected-pet-radiomic-features-remain-the-same
#17
Tetsuya Tsujikawa, Hideaki Tsuyoshi, Masafumi Kanno, Shizuka Yamada, Masato Kobayashi, Norihiko Narita, Hirohiko Kimura, Shigeharu Fujieda, Yoshio Yoshida, Hidehiko Okazawa
Purpose: We investigated whether PET radiomic features are affected by differences in the scanner, scan protocol, and lesion location using 18 F-FDG PET/CT and PET/MR scans. Results: SUV, TMR, skewness, kurtosis, entropy, and homogeneity strongly correlated between PET/CT and PET/MR images. SUVs were significantly higher on PET/MR0-2 min and PET/MR0-10 min than on PET/CT in gynecological cancer ( p = 0.008 and 0.008, respectively), whereas no significant difference was observed between PET/CT, PET/MR0-2 min , and PET/MR0-10 min images in oral cavity/oropharyngeal cancer...
April 17, 2018: Oncotarget
https://www.readbyqxmd.com/read/29753584/a-novel-fluoroscopic-method-for-multidimensional-evaluation-of-swallowing-function
#18
Nobuyuki Arai, Kozo Hanayama, Takaharu Yamazaki, Tetsuya Tomita, Akio Tsubahara, Kazuomi Sugamoto
OBJECTIVE: Dynamic videofluoroscopic swallow study (VFSS) is used to investigate swallowing movements. However, it requires prolonged radiation exposure and mainly provides qualitative information. Herein, we present a multi-dimensional method for analyzing swallowing based on a pulsed, low-dose fluoroscopy technique that uses serial-shot images and evaluates the size, position, and temporal profile of the bolus to obtain a more comprehensive and realistic analysis of swallowing movements...
May 9, 2018: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29752312/slit2-modulates-the-inflammatory-phenotype-of-orbit-infiltrating-fibrocytes-in-graves-disease
#19
Roshini Fernando, Ana Beatriz Diniz Grisolia, Yan Lu, Stephen Atkins, Terry J Smith
Human CD34+ fibrocytes, circulating monocyte lineage progenitor cells, have recently been implicated in thyroid-associated ophthalmopathy (TAO), the ocular manifestation of Graves' disease (GD). Fibrocytes express constitutive MHC class II (MHC-2) and, surprisingly, thyroglobulin (Tg) and functional thyrotropin (TSH) receptor (TSHR). Underlying expression of these thyroid proteins is the autoimmune regulator protein (AIRE). Fibrocytes respond robustly to TSH and thyroid-stimulating Igs by generating extremely high levels of inflammatory cytokines, such as IL-6...
May 11, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29751790/obliterative-cholangiopathy-in-acquired-cystic-biliary-atresia-type-iii-after-cyst-perforation-a-case-report
#20
Tsugumichi Koshinaga, Kensuke Ohashi, Kakou Ono, Hide Kaneda, Takeshi Furuya
BACKGROUND: In biliary atresia, the disease process of obliterative cholangiopathy may begin in the perinatal period; however, no chronological evidence exists on how the cholangiopathy progresses to biliary obliteration. This is the first acquired case with the final diagnosis of type III cystic biliary atresia with an extrahepatic biliary cyst which showed the progression of obliterative cholangiopathy in chronological order after birth. CASE PRESENTATION: An 81-day-old girl presented with acute abdominal distress due to bilious peritonitis caused by biliary cyst perforation, for which she underwent emergency biliary drainage...
May 11, 2018: BMC Pediatrics
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