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https://www.readbyqxmd.com/read/28806208/systemic-hypotension-following-intravenous-administration-of-nonionic-contrast-medium-during-computed-tomography-iopromide-versus-iodixanol
#1
Gerlig Widmann, Reto Bale, Hanno Ulmer, Daniel Putzer, Peter Schullian, Franz-Josef Wiedermann, Wolfgang Lederer
BACKGROUND: In light of the increasing number of radiologic interventions performed under general anesthesia, the effects of contrast media (CM) on circulation and organ perfusion are of paramount importance. The objectives of this study were to systematically quantify effects on blood pressure, heart rate, and kidney function following intravenous administration of nonionic CM with normal and low osmolality. METHODS: In this controlled, double-blinded phase IV clinical trial, 40 consecutive patients were randomly assigned to receive repeated measures of either low-osmolar iopromide or iso-osmolar iodixanol...
August 10, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28805890/effect-of-forage-source-included-in-total-mixed-ration-on-intake-sorting-and-feeding-behavior-of-growing-heifers-fed-high-concentrate-diets
#2
A Madruga, E Mainau, L A González, M Rodríguez-Prado, J L Ruíz de la Torre, X Manteca, A Ferret
The objective of this experiment was to compare the effects of using 2 different forage sources on intake and sorting and feeding behavior in growing heifers fed a high-concentrate diet offered as a total mixed ration (TMR). Eight Simmental heifers (initial BW of 148.1 ± 4.83 kg) were used in a crossover design experiment. Treatment diets were a TMR with either barley straw (BS) or alfalfa hay (AH) as forage source. Diets were offered on an ad libitum basis, with a forage to concentrate ratio of 8 to 92. The experiment was performed in two 28-d periods, with 3 wk of diet adaptation and 1 wk of sampling in each period...
August 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28805314/evolved-%C3%AE-factor-prepro-leaders-for-directed-laccase-evolution-in-saccharomyces-cerevisiae
#3
Ivan Mateljak, Thierry Tron, Miguel Alcalde
Although the functional expression of fungal laccases in Saccharomyces cerevisiae has proven to be complicated, the replacement of signal peptides appears to be a suitable approach to enhance secretion in directed evolution experiments. In this study, twelve constructs were prepared by fusing native and evolved α-factor prepro-leaders from S. cerevisiae to four different laccases with low-, medium- and high-redox potential (PM1L from basidiomycete PM1; PcL from Pycnoporus cinnabarinus; TspC30L from Trametes sp...
August 14, 2017: Microbial Biotechnology
https://www.readbyqxmd.com/read/28802272/transcriptional-analysis-of-an-ammonium-excreting-strain-of-azotobacter-vinelandii-deregulated-for-nitrogen-fixation
#4
Brett M Barney, Mary H Plunkett, Velmurugan Natarajan, Florence Mus, Carolann M Knutson, John W Peters
Biological nitrogen fixation is accomplished by a diverse group of organisms known as diazotrophs, and requires the function of the complex metalloenzyme nitrogenase. Nitrogenase and many of the accessory proteins required for proper cofactor biosynthesis and incorporation into the enzyme have been characterized, but a complete picture of the reaction mechanism and key cellular changes that accompany biological nitrogen fixation remain to be fully elucidated. Studies have revealed that specific disruptions to the anti-activator encoding gene nifL result in the deregulation of the nif transcriptional activator NifA in the nitrogen-fixing bacterium Azotobacter vinelandii, triggering the production of extracellular ammonium levels approaching 30 mM during the stationary phase of growth...
August 11, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28800951/evaluation-of-a-high-concentrated-contrast-media-injection-protocol-in-combination-with-low-tube-current-for-dose-reduction-in-coronary-computed-tomography-angiography-a-randomized-two-center-prospective-study
#5
Yibo Sun, Yanqing Hua, Mingpeng Wang, Dingbiao Mao, Xiu Jin, Cheng Li, Kailei Shi, Jianrong Xu
RATIONALE AND OBJECTIVES: The study aimed to prospectively evaluate the radiation dose reduction potential and image quality (IQ) of a high-concentration contrast media (HCCM) injection protocol in combination with a low tube current (mAs) in coronary computed tomography angiography. MATERIALS AND METHODS: Eighty-one consecutive patients (mean age: 62 years; 34 females; body mass index: 18-31) were included and randomized-assigned into two groups. All computed tomography (CT) examinations were performed in two groups with the same tube voltage (100 kV), flow rate of contrast medium (5...
August 8, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28799253/production-of-bioethanol-in-sugarcane-bagasse-hemicellulosic-hydrolysate-by-scheffersomyces-parashehatae-scheffersomyces-illinoinensis-and-spathaspora-arborariae-isolated-from-brazilian-ecosystems
#6
R M Cadete, M A Melo-Cheab, K J Dussán, R C L B Rodrigues, S S da Silva, F C O Gomes, C A Rosa
AIMS: This study aimed to evaluate new d-xylose-fermenting yeasts from Brazilian ecosystems for the production of second-generation ethanol. METHODS AND RESULTS: d-xylose-fermenting yeasts isolated from rotting wood and wood-boring insects were identified as the species Scheffersomyces parashehatae, Sc. illinoinensis, Spathaspora arborariae, and Wickerhamomyces rabaulensis. Among the yeasts tested, those of Scheffersomyces parashehatae exhibited the highest ethanol production when cultivated on complex medium (Yp/s(et) = 0...
August 11, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28798678/striatal-neuropeptides-enhance-selection-and-rejection-of-sequential-actions
#7
David Buxton, Enrico Bracci, Paul G Overton, Kevin Gurney
The striatum is the primary input nucleus for the basal ganglia, and receives glutamatergic afferents from the cortex. Under the hypothesis that basal ganglia perform action selection, these cortical afferents encode potential "action requests." Previous studies have suggested the striatum may utilize a mutually inhibitory network of medium spiny neurons (MSNs) to filter these requests so that only those of high salience are selected. However, the mechanisms enabling the striatum to perform clean, rapid switching between distinct actions that form part of a learned action sequence are still poorly understood...
2017: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/28797225/environmentally-triggered-genomic-plasticity-and-capsular-polysaccharide-formation-are-involved-in-increased-ethanol-and-acetic-acid-tolerance-in-kozakia-baliensis-nbrc-16680
#8
Julia U Brandt, Friederike-Leonie Born, Frank Jakob, Rudi F Vogel
BACKGROUND: Kozakia baliensis NBRC 16680 secretes a gum-cluster derived heteropolysaccharide and forms a surface pellicle composed of polysaccharides during static cultivation. Furthermore, this strain exhibits two colony types on agar plates; smooth wild-type (S) and rough mutant colonies (R). This switch is caused by a spontaneous transposon insertion into the gumD gene of the gum-cluster, resulting in a heteropolysaccharide secretion deficient, rough phenotype. To elucidate, whether this is a directed switch triggered by environmental factors, we checked the number of R and S colonies under different growth conditions including ethanol and acetic acid supplementation...
August 10, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28797070/methyl-pyruvate-protects-a-normal-lung-fibroblast-cell-line-from-irinotecan-induced-cell-death-potential-use-as-adjunctive-to-chemotherapy
#9
Bernice Monchusi, Monde Ntwasa
The Warburg Effect, characterized by increased rate of glycolysis even under normoxic conditions, is one of the hallmarks of cancer. Relatively lower oxidative phosphorylation (OXPHOS) is also a characteristic feature in cancer cells. We hypothesized that interference with this phenomenon, by introducing exogenous pyruvate, would upset this cancer phenotype and boost the energy requirements of normal cells. We find that methyl pyruvate protects irinotecan-treated normal lung fibroblast cell line (MRC-5) probably by turning off the p53/p21 axis of the apoptotic pathways...
2017: PloS One
https://www.readbyqxmd.com/read/28795216/the-impact-of-pre-existing-conditions-on-functional-outcome-and-mortality-in-geriatric-hip-fracture-patients
#10
Christopher Bliemel, Benjamin Buecking, Ludwig Oberkircher, Matthias Knobe, Steffen Ruchholtz, Daphne Eschbach
PURPOSE: Due to pre-existing illnesses, elderly hip fracture patients represent a vulnerable patient population. The present study was conducted to investigate the effects of various pre-existing conditions on the outcomes of hip fracture patients. METHODS: A total of 402 surgically treated geriatric hip fracture patients were included in this prospective, single-centre study. Upon admission, patient age, gender and fracture type were documented, among other information...
August 9, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28794261/neuroprotective-astrocyte-derived-insulin-igf-1-stimulate-endocytic-processing-and-extracellular-release-of-neuron-bound-a%C3%AE-oligomers
#11
Jason Pitt, Kyle C Wilcox, Vanessa Tortelli, Luan Pereira Diniz, Maira S Oliveira, Cassandra Dobbins, Xiao-Wen Yu, Sathwik Nandamuri, Flávia C A Gomes, Nadia DiNunno, Kirsten L Viola, Fernanda G De Felice, Sergio T Ferreira, William L Klein
Synaptopathy underlying memory deficits in Alzheimer's disease (AD) is increasingly thought to be instigated by toxic oligomers of the amyloid beta peptide (AβOs). Given the long latency and incomplete penetrance of AD dementia with respect to Aβ pathology, we hypothesized that factors present in the CNS may physiologically protect neurons from the deleterious impact of AβOs. Here we employed physically-separated neuron-astrocyte co-cultures to investigate potential non cell-autonomous neuroprotective factors influencing AβO toxicity...
August 9, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28792156/successful-treatment-of-unprotected-left-main-coronary-bifurcation-lesion-using-minimum-contrast-volume-with-intravascular-ultrasound-guidance
#12
Oh Hyun Lee, Chul Min Ahn, Jung Sun Kim, Byeong Keuk Kim, Young Guk Ko, Donghoon Choi, Yangsoo Jang, Myeong Ki Hong
Contrast-induced nephropathy (CIN) is a serious complication in patients undergoing percutaneous coronary intervention (PCI), and is associated with higher morbidity and mortality. The limiting volume of contrast medium is safest and most reliable strategy for CIN prevention. Intravascular ultrasound (IVUS) serves as an attractive alternative imaging tool to angiography in many steps during PCI, thereby reducing the use of contrast agents. Here, we reported a case of successfully treated unprotected left main bifurcation lesion with heavily calcified and diffuse lesion under the IVUS-guided PCI using low volumes of contrast dye of total 12 cc in an elderly patient...
September 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28791518/hardly-water-soluble-drug-loaded-gelatin-nanoparticles-sustaining-a-slow-release-preparation-by-novel-single-step-o-w-o-emulsion-accompanying-solvent-diffusion
#13
E J Lee, K-H Lim
Paclitaxel (PTX)-loaded gelatin nanoparticles (NPs) were prepared, for the first time, by novel O/W/O emulsion with a single-step emulsion process accompanying solvent diffusion, in contrast to the conventional double-step emulsion processes. Linoleic acid was chosen among the natural fatty acids as the exterior medium for the single-step emulsion process accompanying solvent diffusion. The size mean and zeta potential of the PTX-loaded gelatin NPs in their suspension were 164.95 nm (±6.43 nm) distributed with a polydispersity of 0...
August 8, 2017: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/28791434/progressive-occlusion-of-small-saccular-aneurysms-incompletely-occluded-after-stent-assisted-coil-embolization-analysis-of-related-factors-and-long-term-outcomes
#14
Jeong Wook Lim, Jeongjun Lee, Young Dae Cho
PURPOSE: Incompletely occluded aneurysms after coil embolization are subject to recanalization but occasionally progress to a totally occluded state. Deployed stents may actually promote thrombosis of coiled aneurysms. We evaluated outcomes of small aneurysms (<10 mm) wherein saccular filling with contrast medium was evident after stent-assisted coiling, assessing factors implicated in subsequent progressive occlusion. METHODS: Between September 2012 and June 2016, a total of 463 intracranial aneurysms were treated by stent-assisted coil embolization...
August 8, 2017: Clinical Neuroradiology
https://www.readbyqxmd.com/read/28790995/trehalose-polyphleates-external-cell-wall-lipids-in-mycobacterium-abscessus-are-associated-with-the-formation-of-clumps-with-cording-morphology-which-have-been-associated-with-virulence
#15
Marta Llorens-Fons, Míriam Pérez-Trujillo, Esther Julián, Cecilia Brambilla, Fernando Alcaide, Thomas F Byrd, Marina Luquin
Mycobacterium abscessus is a reemerging pathogen that causes pulmonary diseases similar to tuberculosis, which is caused by Mycobacterium tuberculosis. When grown in agar medium, M. abscessus strains generate rough (R) or smooth colonies (S). R morphotypes are more virulent than S morphotypes. In searching for the virulence factors responsible for this difference, R morphotypes have been found to form large aggregates (clumps) that, after being phagocytozed, result in macrophage death. Furthermore, the aggregates released to the extracellular space by damaged macrophages grow, forming unphagocytosable structures that resemble cords...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28790007/targeted-epidural-blood-patch-under-o-arm-guided-stereotactic-navigation-in-patients-with-intracranial-hypotension-associated-with-a-spinal-csf-leak-and-ventral-dural-defect
#16
Keisuke Takai, Makoto Taniguchi
OBJECTIVE: Targeted epidural blood patch (EBP) at the site of a presumed cerebrospinal fluid leak reportedly has better outcomes than non-targeted EBP; however, it is associated with a higher risk of wrong-site injection such as iatrogenic subarachnoid or intramuscular injections, which lead to reintervention due to the insufficient coverage of injected blood. METHODS: Eight patients with intracranial hypotension due to a CSF leak diagnosed by myelographic CT and thin-cut MRI received an epidural blood patch under O-arm-guided stereotactic navigation...
August 5, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28783118/optimization-of-baker-s-yeast-production-on-date-extract-using-response-surface-methodology-rsm
#17
Mounira Kara Ali, Nawel Outili, Asma Ait Kaki, Radia Cherfia, Sara Benhassine, Akila Benaissa, Noreddine Kacem Chaouche
This work aims to study the production of the biomass of S. cerevisiae on an optimized medium using date extract as the only carbon source in order to obtain a good yield of the biomass. The biomass production was carried out according to the central composite experimental design (CCD) as a response surface methodology using Minitab 16 software. Indeed, under optimal biomass production conditions, temperature (32.9 °C), pH (5.35) and the total reducing sugar extracted from dates (70.93 g/L), S. cerevisiae produced 40 g/L of their biomass in an Erlenmeyer after only 16 h of fermentation...
August 7, 2017: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28777459/iodixanol-vs-iopromide-in-cancer-patients-evidence-from-a-randomized-clinical-trial
#18
Irene Terrenato, Francesca Sperati, Felice Mussicco, Anna Fausta Pozzi, Annunziata di Turi, Mauro Caterino, Elisabetta de Lutio di Castelguidone, Sergio Venanzio Setola, Massimo Bellomi, Carlo Emanuele Neumaier, Laura Conti, Giovanni Cigliana, Roberta Merola, Anna Antenucci, Giulia Orlandi, Antonio Giordano, Maddalena Barba, Stefano Canitano
PURPOSE: To assess the safety profile of iso-osmolar contrast medium (CM) vs low osmolar CM in cancer patients with an estimated glomerular filtration rate (eGFR) > 60 ml/min. MATERIALS AND METHODS: In this multicentre, blind trial of patients seeking a chest-abdomen-pelvis CT with iodated CM, participants were centrally randomized to iodixanol or iopromide. Contrast induced nephropathy (CIN) at 24 and/or 72 hours were our primary outcomes. We further considered irreversible CIN, average eGFR percentage variation (%Δ), and adverse events (AEs)...
August 4, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28770484/high-resolution-mr-lymphangiography-for-planning-lymphaticovenous-anastomosis-treatment-a-single-centre-experience
#19
Maria Antonietta Mazzei, Francesco Gentili, Francesco Giuseppe Mazzei, Paolo Gennaro, Duccio Guerrieri, Andrea Nigri, Guido Gabriele, Elisabetta Weber, Alfonso Fausto, Giuseppe Botta, Luca Volterrani
PURPOSE: This article illustrates the feasibility of MR lymphangiography (MRL) for imaging lymphatic vessels in patients with lymphedema, its accuracy in distinguishing lymphatic vessels from veins, and its utility for planning Lymphaticovenous anastomosis (LVA) treatment. MATERIALS AND METHODS: We prospectively enrolled 30 patients (24 women, range 18-70, 17 cases of lower limb lymphedema, 6 cases of primary lymphedema). All the patients underwent MRL, using a 1...
August 2, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28769896/fertilization-shapes-bacterial-community-structure-by-alteration-of-soil-ph
#20
Yuting Zhang, Hong Shen, Xinhua He, Ben W Thomas, Newton Z Lupwayi, Xiying Hao, Matthew C Thomas, Xiaojun Shi
Application of chemical fertilizer or manure can affect soil microorganisms directly by supplying nutrients and indirectly by altering soil pH. However, it remains uncertain which effect mostly shapes microbial community structure. We determined soil bacterial diversity and community structure by 454 pyrosequencing the V1-V3 regions of 16S rRNA genes after 7-years (2007-2014) of applying chemical nitrogen, phosphorus and potassium (NPK) fertilizers, composted manure or their combination to acidic (pH 5.8), near-neutral (pH 6...
2017: Frontiers in Microbiology
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