Tangjinhai Liu, Yuxiang Wang, Jingyi Liu, Xiaowen Han, Yaping Zou, Peilei Wang, Ruiling Xu, Lei Tong, Junli Liu, Jie Liang, Yong Sun, Yujiang Fan, Xingdong Zhang
Skin has a protein microenvironment dominated by functional collagen fibers, while oxidative stress caused by injury can greatly slow down the progress of wound healing. Here, methacrylated dopamine was incorporated into methacrylated silk fibroin molecule chains to develop an injectable hydrogel with photocuring properties for constructing an antioxidant skin protein microenvironment. This silk fibroin-based hydrogel (SF- g -SDA) showed good tensile and adhesion properties for adapting to the wound shape and skin movement, exhibited stable mechanical properties, good biodegradability and cytocompatibility, and promoted cell adhesion and vascularization in vitro ...
February 7, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine