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https://www.readbyqxmd.com/read/28610887/a-hormonal-cue-promotes-timely-follicle-cell-migration-by-modulating-transcription-profiles
#1
Lathiena Manning, Jinal Sheth, Stacey Bridges, Afsoon Saadin, Kamsi Odinammadu, Deborah Andrew, Susan Spencer, Denise Montell, Michelle Starz-Gaiano
Cell migration is essential during animal development. In the Drosophila ovary, the steroid hormone ecdysone coordinates nutrient sensing, growth, and the timing of morphogenesis events including border cell migration. To identify downstream effectors of ecdysone signaling, we profiled gene expression in wild-type follicle cells compared to cells expressing a dominant negative Ecdysone receptor or its coactivator Taiman. Of approximately 400 genes that showed differences in expression, we validated 16 candidate genes for expression in border and centripetal cells, and demonstrated that seven responded to ectopic ecdysone activation by changing their transcriptional levels...
June 10, 2017: Mechanisms of Development
https://www.readbyqxmd.com/read/28609124/the-impact-of-laparoscopic-surgery-of-peritoneal-endometriosis-and-endometrioma-on-the-outcome-of-icsi-cycles
#2
Ismail Guler, Ahmet Erdem, Yuksel Oguz, Funda Cevher, Mehmet Firat Mutlu, Nuray Bozkurt, Mesut Oktem, Mehmet Erdem
Our objective was to assess the role of laparoscopic removal of ovarian endometriomas and ablation of peritoneal endometriosis on the outcome of intracytoplasmic sperm injection (ICSI) - Embryo Transfer cycles by comparing with the results of patients with untreated endometriomas and tubal factor without underlying endometriosis confirmed by laparoscopy. For this purpose, between 2002 and 2015, outcomes of 257 ICSI cycles of 150 patients, including 91 cycles of 48 patients in minimal endometriosis, 57 cycles of 25 patients in endometrioma removal, 65 cycles of 53 patients in non-operated endometrioma, and 44 cycles of 24 patients in tubal factor groups were retrospectively analyzed...
June 13, 2017: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/28607955/wound-healing-protects-against-chemotherapy-induced-alopecia-in-young-rats-via-up-regulating-interleukin-1%C3%AE-mediated-signaling
#3
Olivera Stojadinovic, Tongyu C Wikramanayake, Alexandra C Villasante Fricke, Natalie C Yin, Liang Liang, Eleanor Hinde, Julia Escandon, Marjana Tomic-Canic, David M Ansell, Ralf Paus, Joaquin J Jimenez
Wound healing is a complex process regulated by various cell types and a plethora of mediators. While interactions between wounded skin and the hair follicles (HFs) could induce HF neogenesis or promote wound healing, it remains unknown whether the wound healing-associated signaling milieu can be manipulated to protect against alopecia, such as chemotherapy-induced alopecia (CIA). Utilizing a well-established neonatal rat model of CIA, we show here that skin wounding protects from alopecia caused by several clinically relevant chemotherapeutic regimens, and that protection is dependent on the time of wounding and hair cycle stage...
May 2017: Heliyon
https://www.readbyqxmd.com/read/28598116/-optimal-ovulation-induction-in-polycystic-ovary-syndrome-resistant-to-clomiphene-citrate-or-letrozole
#4
Ying Chen, Dan Zhang
OBJECTIVES: To investigate the optimal ovulation induction with the combination of combining letrozole(LE),clomiphene citrate (CC),and human menopausal gonadotropin (HMG) in polycystic ovary syndrome(PCOS) patients resistant to CC or LE. METHODS: Two hundreds nine PCOS patients (209 cycles) resistant to CC or LE were randomly divided into three groups: CC+HMG group (59 cycles),LE+HMG group (72 cycles) and LE+CC group (78 cycles).The patients in LE+CC group unable to form the dominant follicle after 54 cycles were enrolled into LE+CC+HMG group...
November 2016: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28583593/altered-expression-of-cytokines-il-1%C3%AE-il-6-il-8-and-tnf-%C3%AE-in-bovine-follicular-persistence
#5
A F Stassi, M E Baravalle, E M Belotti, F Rey, N C Gareis, P U Díaz, F M Rodríguez, C J Leiva, H H Ortega, N R Salvetti
In dairy cattle, cystic ovarian disease (COD) is an important cause of subfertility, and two of the main signs are ovulation failure and follicular persistence. The aim of this study was to examine the expression of the cytokines IL-1α, IL-6, IL-8 and TNF-α in ovarian follicular structures at different times of persistence in a model of follicular persistence induced by prolonged treatment with progesterone in dairy cows. Protein expression of IL-1α, IL-6, IL-8 and TNF-α was evaluated by immunohistochemistry...
July 15, 2017: Theriogenology
https://www.readbyqxmd.com/read/28574993/weigh-the-pros-and-cons-to-ovarian-reserve-before-stripping-ovarian-endometriomas-prior-to-ivf-icsi-a-meta-analysis
#6
Xin Tao, Lei Chen, Shuqi Ge, Lisi Cai
PURPOSE: To explore the effects of conservative surgery for endometriomas on ovarian responsiveness during assisted reproductive technology (ART) and provide reproductive and gynecological doctors with a more reliable reference program for the treatment of endometriomas. METHODS: A literature search was performed by searching the PubMed, Embase, Cochrane Library, Web of Science and Science Direct databases. Studies with inter- and intra-patient comparisons of ovarian responses and oocyte quality between operated and unoperated ovaries and that met the inclusion criteria were retrieved, and the data from the outcome measures were extracted and pooled for this meta-analysis...
2017: PloS One
https://www.readbyqxmd.com/read/28542500/uterine-and-systemic-inflammation-influences-ovarian-follicular-function-in-postpartum-dairy-cows
#7
Soon Hon Cheong, Ocilon G Sá Filho, Victor A Absalon-Medina, Augusto Schneider, W R Butler, Robert O Gilbert
The objective of this study was to determine the effects of uterine and systemic inflammatory responses to uterine bacterial contamination at calving in dairy cows on the growth and ovulatory outcomes of the first dominant follicle postpartum. Ovulatory capability of the first dominant follicle postpartum was predicted in 53 multiparous cows by using a combination of follicle growth characteristics and circulating estradiol concentrations. Endotoxin levels were assayed in follicular fluid samples that were aspirated the day after ovulatory outcome prediction...
2017: PloS One
https://www.readbyqxmd.com/read/28532836/follicular-dynamics-ovarian-vascularity-and-luteal-development-in-mares-with-early-or-late-postpartum-ovulation
#8
Kleber Menegon Lemes, Luciano Andrade Silva, Maria Augusta Alonso, Eneiva Carla Carvalho Celeghini, Guilherme Pugliesi, Henrique Fulaneti Carvalho, Fernanda Jordão Affonso, Daniela Franco Silva, Ticiano Guimarães Leite, Rubens Paes de Arruda
Follicular development and deviation processes during the postpartum period are not completely known in horses. Thus, we aimed to study the characteristics of follicular dynamics and ovarian vascular perfusion during the postpartum period in mares that demonstrated estrous behavior and had early (<10 days) or late (≥10 days) postpartum ovulation. Ten mares were scanned daily by transrectal ultrasonography from the first day postpartum (d1) to the sixteenth day after the first postpartum ovulation (D0 = ovulation)...
July 1, 2017: Theriogenology
https://www.readbyqxmd.com/read/28532823/effects-of-rumen-protected-methionine-and-choline-supplementation-on-steroidogenic-potential-of-the-first-postpartum-dominant-follicle-and-expression-of-immune-mediators-in-holstein-cows
#9
D A V Acosta, M I Rivelli, C Skenandore, Z Zhou, D H Keisler, D Luchini, M N Corrêa, F C Cardoso
Multiparous Holstein cows were assigned in a randomized complete block design into four treatments from 21 d before calving to 30 d in milk (DIM). Treatments were: MET [n = 19, fed the basal diet + rumen-protected methionine at a rate of 0.08% (w/w) of the dry matter, Smartamine(®) M], CHO (n = 17, fed the basal diet + choline 60 g/d, Reashure(®)), MIX (n = 21, fed the basal diet + Smartamine(®) M at a rate of 0.08% (w/w) of the dry matter and 60 g/d Reashure(®)), and CON (n = 20, no supplementation, fed the close-up and fresh cow diets)...
July 1, 2017: Theriogenology
https://www.readbyqxmd.com/read/28512199/dominant-negative-sox18-function-inhibits-dermal-papilla-maturation-and-differentiation-in-all-murine-hair-types
#10
Rehan Villani, Samantha Hodgson, Julien Legrand, Jessica Greaney, Ho Yi Wong, Cathy Pichol-Thievend, Christelle Adolphe, Brandon Wainwight, Mathias Francois, Kiarash Khosrotehrani
SOX family proteins SOX2 and SOX18 have been reported as being essential in determining hair follicle type; however, the role they play during development remains unclear. Here, we demonstrate that Sox18 regulates the normal differentiation of the dermal papilla of all hair types. In guard (primary) hair dermal condensate (DC) cells, we identified transient Sox18 in addition to SOX2 expression at E14.5, which allowed fate tracing of primary DC cells until birth. Similarly, expression of Sox18 was detected in the DC cells of secondary hairs at E16...
May 15, 2017: Development
https://www.readbyqxmd.com/read/28486374/premature-thelarche-and-the-pura-syndrome
#11
Joshua Rezkalla, Tiffany Von Wald, Keith A Hansen
BACKGROUND: Premature thelarche is a self-limited condition characterized by Tanner stage II-III breast development in girls younger than 8 years of age with no evidence of advancing puberty. Evaluation concentrates on excluding central or peripheral causes of precocious puberty. CASE: A girl aged 2 years 4 months with profound hypotonia and delayed developmental milestones presented with Tanner II breast development, elevated follicle-stimulating hormone levels, suppressed luteinizing hormone level, normal growth and skeletal development, and prepubertal uterine length and ovarian volume...
June 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28472405/the-ovarian-response-in-fragile-x-patients-and-premutation-carriers-undergoing-ivf-pgd-reappraisal
#12
Sarit Avraham, Benny Almog, Adi Reches, Liat Zakar, Mira Malcov, Amit Sokolov, Sharon Alpern, Foad Azem
STUDY QUESTION: What is the association between the ovarian response and the number of CGG repeats among full mutation and premutation carriers of fragile X (FMR1), undergoing controlled ovarian hyperstimulation (COH) for PGD? SUMMARY ANSWER: Ovarian response was normal in full mutation patients but decreased in premutation carriers, although the number of repeats was not statistically significantly associated with the number of oocytes retrieved. WHAT IS KNOWN ALREADY: There is inconsistent data in the literature regarding ovarian response in FMR1 carriers...
May 3, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28450315/mirna-mrna-network-involved-in-folliculogenesis-interactome-systems-biology-approach
#13
Abolfazl Bahrami, Seyed Reza Miraie-Ashtiani, Mostafa Sadeghi, Ali Najafi
At later phases of folliculogenesis, the mammalian ovarian follicle contains layers of granulosa cells surrounding an antral cavity. To better understand the molecular basis of follicular growth and granulosa cell maturation, we study transcriptome profiling of granulosa cells from small (< 5 mm) and large (> 10 mm) bovine follicles using simultaneous method of Affymetrix microarrays (24,128 probe sets) and RNA-Seq data sets. In this study proposes a computational method to discover the functional miRNA-mRNA regulatory modules, that is, groups of miRNAs and their target mRNAs that are believed to take part cooperatively in post-transcriptional gene regulation under specific conditions...
April 27, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28447195/salivary-mir-16-mir-191-and-mir-223-intuitive-indicators-of-dominant-ovarian-follicles-in-buffaloes
#14
Prashant Singh, Naresh Golla, Pankaj Singh, Vijay Simha Baddela, Subhash Chand, Rubina Kumari Baithalu, Dheer Singh, Suneel Kumar Onteru
Estrus or sexual receptivity determination is utmost important for efficient breeding programs for female buffaloes. Prominent estrus behavioral symptoms are the result of several molecular and neuroendocrine events involving the ovary and the brain. Expression of estrus behavior is poor in buffaloes during the summer season. Hence, the discovery of biomarkers specific to the estrus stage or its related ovarian events, like the presence of dominant ovarian follicle, is helpful for developing an easy estrus determination method...
April 26, 2017: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/28434779/a-comparative-study-of-cutibacterium-propionibacterium-acnes-clones-from-acne-patients-and-healthy-controls
#15
H B Lomholt, C F P Scholz, H Brüggemann, H Tettelin, M Kilian
BACKGROUND: Cutibacterium (Propionibacterium) acnes is assumed to play an important role in the pathogenesis of acne. OBJECTIVES: To examine if clones with distinct virulence properties are associated with acne. METHODS: Multiple C. acnes isolates from follicles and surface skin of patients with moderate to severe acne and healthy controls were characterized by multilocus sequence typing. To determine if CC18 isolates from acne patients differ from those of controls in the possession of virulence genes or lack of genes conducive to a harmonious coexistence the full genomes of dominating CC18 follicular clones from six patients and five controls were sequenced...
April 19, 2017: Anaerobe
https://www.readbyqxmd.com/read/28434724/the-effect-of-presynchronization-with-prostaglandin-f2%C3%AE-and-gonadotropin-releasing-hormone-simultaneously-7-d-before-ovsynch-compared-with-presynch-10-ovsynch-on-luteal-function-and-first-service-pregnancies-per-artificial-insemination
#16
J P N Martins, M J T Acevedo, T O Cunha, C Piterini, J R Pursley
Pregnancy per artificial insemination (P/AI) following Ovsynch is optimized when cows ovulate to the first GnRH of Ovsynch. Fertility programs are designed to presynchronize cows to d 6 or 7 of the estrous cycle to increase the chances of ovulation of a first-wave dominant follicle to the first GnRH of Ovsynch. The hypothesis of this experiment was that simplification of a presynchronization program through the combination of PGF2α and GnRH on the same day, 7 d before Ovsynch, would allow for similar P/AI compared with Presynch-10...
April 20, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28428942/follicular-fluid-cerebellin-and-betatrophin-regulate-the-metabolic-functions-of-growing-follicles-in-polycystic-ovary-syndrome
#17
Aynur Adeviye Ersahin, Mustafa Acet, Suat Suphan Ersahin, Tuba Acet, Meltem Yardim, Omer Kenanoglu, Suleyman Aydin
OBJECTIVE: The aim of this study was to assess the changes of follicular fluid (FF) and serum levels of cerebellin precursor protein 1 (cbln1) and betatrophin in patients with polycystic ovary syndrome (PCOS) undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) with a gonadotropin-releasing hormone (GnRH) antagonist protocol. METHODS: Twenty infertile women with PCOS and 20 control women diagnosed as poor responders undergoing ovarian stimulation with a GnRH antagonist were included...
March 2017: Clinical and Experimental Reproductive Medicine
https://www.readbyqxmd.com/read/28396984/iodinated-tg-in-thyroid-follicles-regulate-tsh-tshr-signaling-for-nis-expression
#18
Huibin Huang, Yaxiong Shi, Bo Liang, Huiyao Cai, Qingyan Cai
Our previous research has suggested that high degree of iodinated thyroglobulin (TG) may inhibit the expression and function of sodium iodide symporter (NIS), but the underlying mechanism remains unclear. In present study, we discuss a newly constructed follicle model in vitro, which was used to simulate the follicular structure of the thyroid and explore the regulatory roles of iodinated TG in the follicular lumen on NIS expression. The results showed that both NIS expression and PKA activity were increased in lowly iodinated TG group, while decreased NIS expression with increased PKC activity was found in highly iodinated TG group...
April 10, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28380577/the-effect-of-follicular-wave-on-fertility-characteristics-in-beef-cattle
#19
A M Muth-Spurlock, J A Dix, M P T Coleson, C G Hart, C O Lemley, T M Schulmeister, G C Lamb, J E Larson
The objectives of this experiment were to determine the effects of follicular wave (first or second) on diameter of the dominant follicle, concentrations of progesterone and estradiol and the hepatic enzymes that inactivate them, thickness of the endometrium, and pregnancy rates to AI. Beef heifers ( = 101) and cows ( = 106) were randomly assigned to 1 of 2 treatments: insemination to the first follicular wave (FFW) or insemination to the second follicular wave (SFW). Estrous cycles of females were synchronized to ensure appropriate timing for the treatments...
February 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28378464/luteal-activity-and-effect-of-dietary-energy-restriction-on-follicular-development-in-lactating-cows
#20
A Comin, T Peric, M Montillo, A Cappa, V Marchi, M C Veronesi, A Prandi
The aim of this research has been to evaluate the presence of anomalies in the ovarian cycle activity during postpartum and to verify whether 72-hr dietary fasting during the dominance phase, the phase before ovulation, might modify the ovarian follicle population. The presence of anomalies in ovarian cycle activity has been evaluated in 30 Italian Friesian cows starting from 20 days postpartum until 211 days of lactation. Long oestrus and brief dioestrus or scarce luteal activity have been the main anomalies found through measuring progesterone concentrations in the whey...
April 4, 2017: Reproduction in Domestic Animals, Zuchthygiene
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