keyword
https://read.qxmd.com/read/38370159/invasive-coronary-imaging-of-inflammation-to-further-characterize-high-risk-lesions-what-options-do-we-have
#21
REVIEW
Jonathan Los, Frans B Mensink, Niekbachsh Mohammadnia, Tjerk S J Opstal, Peter Damman, Rick H J A Volleberg, Denise A M Peeters, Niels van Royen, Hector M Garcia-Garcia, Jan H Cornel, Saloua El Messaoudi, Robert-Jan M van Geuns
Coronary atherosclerosis remains a leading cause of morbidity and mortality worldwide. The underlying pathophysiology includes a complex interplay of endothelial dysfunction, lipid accumulation and inflammatory pathways. Multiple structural and inflammatory features of the atherosclerotic lesions have become targets to identify high-risk lesions. Various intracoronary imaging devices have been developed to assess the morphological, biocompositional and molecular profile of the intracoronary atheromata. These techniques guide interventional and therapeutical management and allow the identification and stratification of atherosclerotic lesions...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38353228/plasma-markers-of-alzheimer-s-disease-pathology-neuronal-injury-and-astrocytic-activation-and-mri-load-of-vascular-pathology-and-neurodegeneration-the%C3%A2-smart-mr-study
#22
JOURNAL ARTICLE
Emma L Twait, Lotte Gerritsen, Justine E F Moonen, Inge M W Verberk, Charlotte E Teunissen, Pieter Jelle Visser, Wiesje M van der Flier, Mirjam I Geerlings
BACKGROUND: Two of the main causes for dementia are Alzheimer's disease (AD) and vascular pathology, with most patients showing mixed pathology. Plasma biomarkers for Alzheimer's disease-related pathology have recently emerged, including Aβ (amyloid-beta), p-tau (phosphorylated tau), NfL (neurofilament light), and GFAP (glial fibrillary acidic protein). There is a current gap in the literature regarding whether there is an association between these plasma biomarkers with vascular pathology and neurodegeneration...
February 14, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38340655/hyaluronic-acid-modified-mesoporous-silica-nanoprobes-for-target-identification-of-atherosclerosis
#23
JOURNAL ARTICLE
Ruifan Ma, Liguo Hao, Jianing Cheng, Jun He, Qiangqiang Yin, Zhongtao Li, Guiqiang Qi, Xiaoyang Zheng, Dongxu Wang, Tianyu Zhang, Houyi Cong, Zheng Li, Haifeng Hu, Yuguang Wang
Rupture of vulnerable plaque and secondary thrombosis caused by atherosclerosis are one of the main causes of acute cardiovascular and cerebrovascular events, and it is urgent to develop an in-situ, noninvasive, sensitive and targeted detection method at molecular level. We chose CD44, a specific receptor highly expressed on the surface of macrophages, as the target of the molecular probe, and modified the CD44 ligand HA onto the surface of Gd2 O3 @MSN, constructing the MRI imaging nanoprobe HA-Gd2 O3 @MSN for targeted recognition of atherosclerosis...
February 5, 2024: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/38338993/intrastent-restenosis-a-comprehensive-review
#24
REVIEW
Ioan-Teodor Bajeu, Adelina-Gabriela Niculescu, Alexandru Scafa-Udriște, Ecaterina Andronescu
The primary objective of this paper is to delineate and elucidate the contemporary advancements, developments, and prevailing trajectories concerning intrastent restenosis (ISR). We aim to provide a thorough overview of the most recent developments in this area, covering various aspects such as pathophysiological insights, therapeutic approaches, and new strategies for tackling the complex challenges of ISR in modern clinical settings. The authors have undertaken a study to address a relatively new medical challenge, recognizing its significant impact on the morbidity and mortality of individuals with cardiovascular diseases...
January 30, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38334677/shear-stress-and-sub-femtomolar-levels-of-ligand-synergize-to-activate-alk1-signaling-in-endothelial-cells
#25
JOURNAL ARTICLE
Ya-Wen Cheng, Anthony R Anzell, Stefanie A Morosky, Tristin A Schwartze, Cynthia S Hinck, Andrew P Hinck, Beth L Roman, Lance A Davidson
Endothelial cells (ECs) respond to concurrent stimulation by biochemical factors and wall shear stress (SS) exerted by blood flow. Disruptions in flow-induced responses can result in remodeling issues and cardiovascular diseases, but the detailed mechanisms linking flow-mechanical cues and biochemical signaling remain unclear. Activin receptor-like kinase 1 (ALK1) integrates SS and ALK1-ligand cues in ECs; ALK1 mutations cause hereditary hemorrhagic telangiectasia (HHT), marked by arteriovenous malformation (AVM) development...
February 5, 2024: Cells
https://read.qxmd.com/read/38326208/multi-lumen-coronary-artery-the-role-of-intracoronary-imaging
#26
Fernando Mané, Rodrigo Silva, Inês Conde, Carlos Braga, João Costa
No abstract text is available yet for this article.
February 1, 2024: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://read.qxmd.com/read/38324224/the-rotterdam-study-design-update-and-major-findings-between-2020-and-2024
#27
JOURNAL ARTICLE
M Arfan Ikram, Brenda C T Kieboom, Willem Pieter Brouwer, Guy Brusselle, Layal Chaker, Mohsen Ghanbari, André Goedegebure, M Kamran Ikram, Maryam Kavousi, Rob J de Knegt, Annemarie I Luik, Joyce van Meurs, Luba M Pardo, Fernando Rivadeneira, Frank J A van Rooij, Meike W Vernooij, Trudy Voortman, Natalie Terzikhan
The Rotterdam Study is a population-based cohort study, started in 1990 in the district of Ommoord in the city of Rotterdam, the Netherlands, with the aim to describe the prevalence and incidence, unravel the etiology, and identify targets for prediction, prevention or intervention of multifactorial diseases in mid-life and elderly. The study currently includes 17,931 participants (overall response rate 65%), aged 40 years and over, who are examined in-person every 3 to 5 years in a dedicated research facility, and who are followed-up continuously through automated linkage with health care providers, both regionally and nationally...
February 7, 2024: European Journal of Epidemiology
https://read.qxmd.com/read/38323314/gut-ribotoxic-stress-responses-facilitate-dyslipidemia-via-metabolic-reprogramming-an-environmental-health-prediction
#28
JOURNAL ARTICLE
Juil Kim, Hoyoung Jeong, Navin Ray, Ki-Hyung Kim, Yuseok Moon
Rationale: The gut and its accessory organ, the liver, are crucial determinants of metabolic homeostasis via the regulation of circulating lipids for cardiovascular health. In response to environmental insults, cells undergo diverse adaptation or pathophysiological processes via stress-responsive eukaryotic initiation factor 2 alpha (eIF2α) kinase signaling and subsequent cellular reprogramming. We noted that patients with inflammatory gut distress display enhanced levels of ribosomal stress-responsive eIF2α kinase, which is notably associated with lipid metabolic process genes...
2024: Theranostics
https://read.qxmd.com/read/38319570/a-luciferase-reporter-assay-to-detect-cellular-hypoxia-in-vitro
#29
JOURNAL ARTICLE
Masayuki Inubushi, Yasuto Takeuchi, Chika Murai, Yoshimasa Kitagawa
Hypoxia is a hallmark of ischemic cardiovascular diseases and solid malignant tumors. Cellular hypoxia induces numerous physiological and pathological processes, including hematopoiesis, angiogenesis, metabolic changes, cell growth, and apoptosis. Hypoxia-inducible factor-1 (HIF-1) binds to hypoxia response elements (HREs) to selectively induce the expression of various genes in response to hypoxia. Therefore, HREs have been used to develop hypoxia-targeted gene therapy.More than 70 pairs of HREs and hypoxia-inducible genes have been identified...
2024: Methods in Molecular Biology
https://read.qxmd.com/read/38313450/delayed-68-ga-fapi-46-pet-mr-imaging-confirms-ongoing-fibroblast-activation-in-patients-after-acute-myocardial-infarction
#30
JOURNAL ARTICLE
Jana Kupusovic, Lukas Kessler, Sandra Kazek, Michal Kamil Chodyla, Lale Umutlu, Fadi Zarrad, Michael Nader, Wolfgang P Fendler, Zohreh Varasteh, Ken Hermann, Dobromir Dobrev, Reza Wakili, Tienush Rassaf, Johannes Siebermair, Christoph Rischpler
PURPOSE OF THE REPORT: Combined cardiac 68 Ga-Fibroblast-Activation Protein-alpha inhibitor (FAPI) positron-emission tomography (PET) and cardiac magnetic resonance imaging (MRI) constitute a novel diagnostic tool in patients for the assessment of myocardial damage after an acute myocardial infarction (AMI). Purpose of this pilot study was to evaluate simultaneous Ga-68-FAPI-46-PET/MR imaging in the delayed phase after AMI. MATERIAL AND METHODS: Eleven patients underwent hybrid 68 Ga-FAPI-46 PET/MRI post AMI...
February 2024: IJC Heart & Vasculature
https://read.qxmd.com/read/38292957/lipid-disorders-and-cardiovascular-risk-a-comprehensive-analysis-of-current-perspectives
#31
REVIEW
Maha Wazir, Olusegun A Olanrewaju, Muhammad Yahya, Jaya Kumari, Narendar Kumar, Jagjeet Singh, Abbas Yasir Abbas Al-Itbi, Komal Kumari, Aqsa Ahmed, Tamur Islam, Giustino Varrassi, Mahima Khatri, Satesh Kumar, Hina Wazir, Syed S Raza
The increasing worldwide prevalence of cardiovascular diseases (CVDs) highlights the need to understand the complex relationships between lipid abnormalities and elevated cardiovascular risk. This review thoroughly investigates the complex terrain of lipid abnormalities, highlighting their crucial significance in developing CVDs. Dyslipidemia, which is closely connected to atherosclerosis, is a significant risk factor for CVDs, including coronary artery disease, myocardial infarction, and stroke. This review thoroughly examines the intricate relationship between lipoproteins, cholesterol metabolism, and the inflammatory cascade, providing a detailed comprehension of the mechanisms that contribute to atherogenic processes...
December 2023: Curēus
https://read.qxmd.com/read/38281956/venovenous-extracorporeal-membrane-oxygenation-after-cardiac-arrest-for-acute-respiratory-distress-syndrome-caused-by-legionella-a-case-report
#32
JOURNAL ARTICLE
John C Grotberg, Linda Schulte, Erin Schumer, Mary Sullivan, Kunal Kotkar, Mohammad F Masood, Amit Pawale
BACKGROUND: Legionella remains underdiagnosed in the intensive care unit and can progress to acute respiratory distress syndrome (ARDS), multiorgan failure and death. In severe cases, venovenous extracorporeal membrane oxygenation (VV-ECMO) allows time for resolution of disease with Legionella-targeted therapy. VV-ECMO outcomes for Legionella are favorable with reported survival greater than 70%. Rapid molecular polymerase chain reaction (PCR) testing of the lower respiratory tract aids in diagnosing Legionella with high sensitivity and specificity...
January 28, 2024: Journal of Cardiothoracic Surgery
https://read.qxmd.com/read/38279589/exploring-the-comorbidity-mechanisms-between-psoriasis-and-obesity-based-on-bioinformatics
#33
JOURNAL ARTICLE
Changyong Gao, Jianhong Li
BACKGROUND: Psoriasis is a chronic, recurrent, immune-mediated inflammatory skin disease characterized by erythematous scaly lesions. Obesity is currently a major global health concern, increasing the risk of diseases such as cardiovascular diseases and diabetes. Since the correlation between psoriasis and obesity, as well as hypertension, diabetes, and cardiovascular diseases, has been clinically evidenced, it is of certain clinical significance to explore the mechanisms underlying the comorbidity of psoriasis with these conditions...
February 2024: Skin Research and Technology
https://read.qxmd.com/read/38279275/morphological-and-genetic-aspects-for-post-mortem-diagnosis-of-hypertrophic-cardiomyopathy-a-systematic-review
#34
REVIEW
Vincenzo Cianci, Elena Forzese, Daniela Sapienza, Luigi Cardia, Alessio Cianci, Antonino Germanà, Lorenzo Tornese, Antonio Ieni, Patrizia Gualniera, Alessio Asmundo, Cristina Mondello
Hypertrophic cardiomyopathy (HCM) is one of the most common genetic cardiovascular diseases, and it shows an autosomal dominant pattern of inheritance. HCM can be clinically silent, and sudden unexpected death due to malignant arrhythmias may be the first manifestation. Thus, the HCM diagnosis could be performed at a clinical and judicial autopsy and offer useful findings on morphological features; moreover, it could integrate the knowledge on the genetic aspect of the disease. This review aims to systematically analyze the literature on the main post-mortem investigations and the related findings of HCM to reach a well-characterized and stringent diagnosis; the review was performed using PubMed and Scopus databases...
January 20, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38275185/noninvasive-imaging-modalities-in-coronary-artery-disease-a-meta-analysis-comparing-coronary-computed-tomography-angiography-and-standard-of-care
#35
REVIEW
Avichal Dani, Pari Shah, Dev Desai
Introduction: Coronary artery disease has become a global pandemic and a major cause of death. The risk-factor calculation for coronary artery damage is an invasive procedure. Aim: To compare coronary computed tomography angiography (CCTA) with standard of care (SOC) to calculate need for revascularization, invasive coronary angiography as well as for myocardial infarction (MI) incidence and all-cause mortality. Methodology, results & conclusion: CCTA is significantly correlated with a reduction in MI episodes (RR = 0...
January 26, 2024: Future Cardiology
https://read.qxmd.com/read/38269231/cardio-oncology-managing-cardiovascular-complications-of-cancer-therapies
#36
REVIEW
Roshan Sharma, Jyoti Kashyap, Olusegun A Olanrewaju, Abdul Jabbar, Fnu Someshwar, Hira Saeed, Giustino Varrassi, Hafiza Amna Qadeer, Satish Kumar, Asfand Yar Cheema, Mahima Khatri, Maha Wazir, Farhan Ullah
This narrative review explores the complex relationship between cancer medicines and cardiovascular health in the junction of oncology and cardiology, known as cardio-oncology. The study examines the historical development of cancer treatments and highlights the growing importance of cardiovascular problems in patient care. This text delves into the topic of cardiotoxicity, examining both conventional chemotherapeutic drugs like anthracyclines and more recent tyrosine kinase and immune checkpoint inhibitors...
December 2023: Curēus
https://read.qxmd.com/read/38266693/recent-advancement-in-nanotechnology-based-drug-delivery-for-the-management-of-cardiovascular-disease
#37
REVIEW
Aziz Ullah, Muneeb Ullah, Sung In Lim
Cardiovascular diseases (CVDs) constitute a predominant cause of both global mortality and morbidity. To address the challenges in the early diagnosis and management of CVDs, there is growing interest in the field of nanotechnology and nanomaterials to develop innovative diagnostic and therapeutic approaches. This review focuses on the recent advancements in nanotechnology-based diagnostic techniques, including cardiac immunoassays (CIA), cardiac circulating biomarkers, cardiac exosomal biomarkers, and molecular Imaging (MOI)...
January 22, 2024: Current Problems in Cardiology
https://read.qxmd.com/read/38256075/metal-based-nanoparticles-for-cardiovascular-diseases
#38
REVIEW
Alexandru Scafa Udriște, Alexandra Cristina Burdușel, Adelina-Gabriela Niculescu, Marius Rădulescu, Alexandru Mihai Grumezescu
Globally, cardiovascular diseases (CVDs) are the leading cause of death and disability. While there are many therapeutic alternatives available for the management of CVDs, the majority of classic therapeutic strategies were found to be ineffective at stopping or significantly/additionally slowing the progression of these diseases, or they had unfavorable side effects. Numerous metal-based nanoparticles (NPs) have been created to overcome these limitations, demonstrating encouraging possibilities in the treatment of CVDs due to advancements in nanotechnology...
January 13, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38255973/what-we-know-about-and-what-is-new-in-primary-aldosteronism
#39
REVIEW
Natalia Ekman, Ashley B Grossman, Dorota Dworakowska
Primary aldosteronism (PA), a significant and curable cause of secondary hypertension, is seen in 5-10% of hypertensive patients, with its prevalence contingent upon the severity of the hypertension. The principal aetiologies of PA include bilateral idiopathic hypertrophy (BIH) and aldosterone-producing adenomas (APAs), while the less frequent causes include unilateral hyperplasia, familial hyperaldosteronism (FH) types I-IV, aldosterone-producing carcinoma, and ectopic aldosterone synthesis. This condition, characterised by excessive aldosterone secretion, leads to augmented sodium and water reabsorption alongside potassium loss, culminating in distinct clinical hallmarks: elevated aldosterone levels, suppressed renin levels, and hypertension...
January 11, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38245289/cardiac-amyloidosis-in-latin-america-gaps-and-opportunities-to-increase-awareness-of-the-disease-findings-from-the-amilo-latam-research-group
#40
JOURNAL ARTICLE
Fernando Mut, Isabel Carvajal, Jorge Camilletti, Juan Erriest, Erick Alexanderson, Gabriel Blacher Grossman
BACKGROUND: Cardiac amyloidosis (CA) is an under-diagnosed disease presenting as a restrictive cardiomyopathy with high morbidity and mortality. Wild-type transthyretin amyloid cardiomyopathy (ATTR-CM) is mostly seen in elderly patients, with increasing prevalence as life expectancy is growing. New diagnostic imaging techniques and treatments allow for a better prognosis, but lack of clinical awareness delays timely diagnosis and appropriate management. Our purpose was to investigate the knowledge of clinicians regarding ATTR-CM and to assess the availability of imaging resources in the Latin-American region...
August 2023: Journal of Nuclear Cardiology
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