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Auricular cartilage

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https://www.readbyqxmd.com/read/29766656/microencapsulated-rabbit-adipose-stem-cells-initiate-tissue-regeneration-in-a-rabbit-ear-defect-model
#1
Shirae K Leslie, David J Cohen, Sharon L Hyzy, Christopher R Dosier, Anthony Nicolini, Janina Sedlaczek, Zvi Schwartz, Barbara D Boyan
Cell-based tissue engineering can promote cartilage tissue regeneration, but cell retention in the implant site post-delivery is problematic. Alginate microbeads containing adipose stem cells (ASCs) pretreated with chondrogenic media (CM) have been used successfully to regenerate hyaline cartilage in critical size defects in rat xiphoid suggesting that they may be used to treat defects in elastic cartilages like the ear. To test this, we used microbeads made with low viscosity, high mannuronate medical grade alginate using a high electrostatic potential and a calcium cross linking solution containing glucose...
May 15, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29743810/auricular-cartilage-regeneration-with-adipose-derived-stem-cells-in-rabbits
#2
Se-Joon Oh, Hee-Young Park, Kyung-Un Choi, Sung-Won Choi, Sung-Dong Kim, Soo-Keun Kong, Kyu-Sup Cho
Tissue engineering cell-based therapy using induced pluripotent stem cells and adipose-derived stem cells (ASCs) may be promising tools for therapeutic applications in tissue engineering because of their abundance, relatively easy harvesting, and high proliferation potential. The purpose of this study was to investigate whether ASCs can promote the auricular cartilage regeneration in the rabbit. In order to assess their differentiation ability, ASCs were injected into the midportion of a surgically created auricular cartilage defect in the rabbit...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29679738/the-auricular-cartilage-graft-used-as-interpositional-material-for-disc-replacement-after-failed-tmj-operative-arthroscopy
#3
Mario Fernando Muñoz-Guerra, Francisco José Rodríguez-Campo, Manuel Fernández-Domínguez
OBJECTIVES: The aim of this study was to evaluate the preoperative and 2-years postoperative clinical and radiological findings in a group of patients after temporomandibular joint discectomy and interpositional autogenous auricular cartilage graft. MATERIALS AND METHODS: The technique involved a disc removal, condylar remodeling and fixation of the graft to the fossa-eminence region. Preoperative and 2-years postoperative clinical findings and magnetic resonance features were evaluated in a group of 13 patients (fourteen joints)...
April 18, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29664828/modified-2-stage-method-for-auricular-reconstruction
#4
Tengxiao Ma, Feng Xie, Zhengwen Zhang
BACKGROUND: Auricular reconstruction is one of the most challenging procedures in the field of plastic surgery. The aims of this study were to apply the modified 2-stage method to perform auricular reconstruction and to summarize the clinical experience in the past 10 years. METHODS: Auricular reconstruction was performed in 243 patients (total 254 ears) of congenital microtia using autologous costal cartilage. The whole procedure is divided into 2 stages. Stage I: the individualized framework fabricated with autologous costal cartilage is inserted into subcutaneous pocket in the mastoid region, and then the earlobe was transposed backward to connect with the lower part of the framework...
June 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29652536/computed-tomography-assisted-auricular-cartilage-graft-for-depression-of-the-alar-base-in-secondary-unilateral-cleft-lip-repair-a-preliminary-report
#5
Hong Chen, Chun-Ye Chen, Qing-Qing Fang, Min-Xia Zhang, Wan-Yi Zhao, Xiao-Feng Wang, Wei-Qiang Tan, Li-Yun Zhang
OBJECTIVES: To evaluate the feasibility, effectiveness, and safety of computed tomography-assisted auricular cartilage grafting for treating alar base depression secondary to unilateral cleft lip. DESIGN AND SETTING: For patients with obvious depression of the alar base, the difference in heights of the alar base and the piriform margin between the cleft side and the noncleft side were measured with computed tomography. If both were >3.0 mm, the cartilage was harvested postauricularly and subdivided into 2 to 4 pieces...
January 1, 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29607095/auricular-reconstruction-from-rib-to-3d-printing
#6
REVIEW
Chelsea L Reighard, Scott J Hollister, David A Zopf
The human ear imparts critical form and function and remains one of the most challenging facial features to reconstruct. Over the past century, surgeons have developed numerous techniques and materials for total auricular reconstruction. Refined costal cartilage techniques have remained the gold standard for the past half-century. Recent advancements with novel materials, tissue engineering and 3D printing provide immense potential; however, prohibitive costs and regulatory steps remain as barriers to clinical translation...
January 2018: Journal of 3D printing in medicine
https://www.readbyqxmd.com/read/29595733/predictors-for-unfavorable-projection-of-the-constructed-auricle-following-ear-elevation-surgery-in-microtia-reconstruction
#7
Kyeong-Tae Lee, Kap Sung Oh
BACKGROUND: Nagata's two-stage technique for microtia reconstruction using autologous costal cartilage consists of the implantation of a fabricated cartilage framework and the elevation of the constructed auricle. Achieving long-lasting, sufficient projection of the auricle is a goal of second-stage surgery; however, unfavorable outcomes have been seen in some patients, with suboptimal long-term elevation. The present study aimed to investigate prognostic factors that might contribute to adverse outcomes following the ear elevation operation...
April 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29566447/posterior-auricular-artery-as-a-novel-anatomic-landmark-for-identification-of-the-facial-nerve-a-cadaveric-study
#8
Muyuan Liu, Steven J Wang, Arnau Benet, Ali Tayebi Meybodi, Halima Tabani, Ivan H Ei-Sayed
BACKGROUND: Despite preservation techniques, performing a parotidectomy carries a transient facial nerve dysfunction rate in up to 65% of cases and a permanent facial nerve weakness rate of 4%-7%. METHODS: The lateral aspect of the face and neck was exposed in 5 cadaveric heads (10 sides). The relationship of the posterior auricular artery (PAA) and the facial nerve was studied and recorded and descriptive measurements were taken. RESULTS: In all specimens, the facial nerve trunk crossed the PAA inferior to the stylomastoid foramen and could be identified precisely by tracing the PAA proximally...
March 22, 2018: Head & Neck
https://www.readbyqxmd.com/read/29554454/ear-scaffold-reconstruction-using-ultrasonic-aspirator-for-cauliflower-ear
#9
Scarlett Hao, Kristen Angster, Fleesie Hubbard, Jewel Greywoode, Kalpesh T Vakharia
Untreated auricular hematomas from ear trauma can result in an ear deformation known as cauliflower ear, secondary to fibrosis and new cartilage overgrowth. Cauliflower ear reconstruction has traditionally utilized tools such as a drill or a scalpel in order to improve auricular cosmesis. We present a case report utilizing an ultrasonic aspirator to recontour the fibrosed cartilage of a cauliflower ear. The ultrasonic aspirator has advantages over traditional tools in its ability to provide finely controlled bone removal without damage to surrounding soft tissue...
April 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29545031/a-new-technique-for-transcutaneous-fixation-of-the-costal-cartilage-block-utilized-in-reconstructed-ear-elevation-for-microtia
#10
So Young Kim, Sun-June Park, Kap Sung Oh
PURPOSE: With the aim of implementing good projection of the three-dimensional frame (auriculo-cephalic angle) and maintaining projection, a significant issue during the stage of auricular elevation for avoiding the potential for dislodging the cartilage blocks remains. Herein we present an innovative and technically simple method of transcutaneous fixation of the costal cartilage block during the stage of auricular elevation. MATERIALS AND METHODS: After elevation of ear frame from the basement, two suspension stitches on the surface of the elevated ear were used to fix the embedding cartilage block into the auriculo-cephalic sulcus at the upper (bifurcation point of the anti-helix where the inferior and superior crus meet to form the triangular fossa) and lower (projection point of the concha wall, parallel to the level of the tragus) ones...
April 2018: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29537998/tissue-engineering-auricular-cartilage-using-late-passage-human-auricular-chondrocytes
#11
Jaime L Bernstein, Benjamin P Cohen, Alexandra Lin, Alice Harper, Lawrence J Bonassar, Jason A Spector
PURPOSE: The significant shortcomings associated with current autologous reconstructive options for auricular deformities have inspired great interest in a tissue engineering solution. A major obstacle in the engineering of human auricular cartilage is the availability of sufficient autologous human chondrocytes. A clinically obtainable amount of auricular cartilage tissue (ie, 1 g) only yields approximately 10 million cells, where 25 times this amount is needed for the fabrication of a full-scale pediatric ear...
April 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29485180/progenitor-cells-in-auricular-cartilage-demonstrate-cartilage-forming-capacity-in-3d-hydrogel-culture
#12
I A Otto, R Levato, W R Webb, I M Khan, C C Breugem, J Malda
Paramount for the generation of auricular structures of clinically-relevant size is the acquisition of a large number of cells maintaining an elastic cartilage phenotype, which is the key in producing a tissue capable of withstanding forces subjected to the auricle. Current regenerative medicine strategies utilize chondrocytes from various locations or mesenchymal stromal cells (MSCs). However, the quality of neo-tissues resulting from these cell types is inadequate due to inefficient chondrogenic differentiation and endochondral ossification, respectively...
February 27, 2018: European Cells & Materials
https://www.readbyqxmd.com/read/29481517/iatrogenic-conchal-defect-secondary-to-auricular-cartilage-graft
#13
Leela S Mundra, Husain T AlQattan, Meghan G Janette, Carissa Patete, Seth R Thaller
BACKGROUND: Cleft lip and palate are the most common craniofacial congenital malformations. Timing of the nasal repair remains somewhat controversial. Some authors perform a combined nasal and lip repair in infancy while others advocate for a staged repair with the nasal component occurring later in childhood. Frequently, secondary repair is needed to address residual nasal deformities in early adulthood. Conchal cartilage has become increasingly popular as a source of cartilage for secondary reconstruction...
February 23, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29449572/optimising-the-decellularization-of-human-elastic-cartilage-with-trypsin-for-future-use-in-ear-reconstruction
#14
Shafiq Rahman, Michelle Griffin, Anish Naik, Matthew Szarko, Peter E M Butler
Decellularized scaffolds can induce chondrogenic differentiation of stem cells. This study compares different methods to optimise the decellularization of auricular cartilage. The process consisted of an initial 12 hour dry freeze thaw which froze the cartilage specimens in an empty tube at -20 °C. Samples were allowed to thaw at room temperature followed by submersion in phosphate buffer solution in which they were frozen at -20 °C for a 12 hour period. They were then allowed to thaw at room temperature as before...
February 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29447327/-unknown-title
#15
(no author information available yet)
BACKGROUND: The lack of nasal tip support resulting in poor protection and projection of the nose is a common cause of nasal obstruction and cosmetic impairment. Although septal cartilage is preferred for restoration of nasal tip support, there is often not enough septal cartilage available. We describe an intercrural columellar strut graft in a circumferential soft tissue pocket: the I-Beam technique. METHODOLOGY: In this cohort study over an 8-year period the clinical and biometrical long-term results after restoration of nasal tip support with an autologous auricular cartilage graft, the I-Beam technique, is evaluated...
February 15, 2018: Rhinology
https://www.readbyqxmd.com/read/29447325/long-term-results-after-restoring-nasal-tip-support-using-auricular-cartilage-as-an-intercrural-columellar-strut-graft-the-i-beam-technique
#16
E Novoa, D Simmen, H R Briner, C Schlegel
BACKGROUND: The lack of nasal tip support resulting in poor protection and projection of the nose is a common cause of nasal obstruction and cosmetic impairment. Although septal cartilage is preferred for restoration of nasal tip support, there is often not enough septal cartilage available. We describe an intercrural columellar strut graft in a circumferential soft tissue pocket: the I-Beam technique. METHODOLOGY: In this cohort study over an 8-year period the clinical and biometrical long-term results after restoration of nasal tip support with an autologous auricular cartilage graft, the I-Beam technique, is evaluated...
February 15, 2018: Rhinology
https://www.readbyqxmd.com/read/29433146/reconstruction-of-tragus-and-external-auditory-meatus-using-remnant-auricle-during-microtia-reconstruction
#17
Gao-Feng Li, Yi-Gao Hu, Wei Ding, Jun Tan, Xin Chen, Tao Luo, Bo Zhang, Xiao-Jia Liu
This article investigates an effective method with which to reconstruct the tragus and external auditory meatus for microtia reconstruction. The external ear was reconstructed using a delayed postauricular skin flap in patients with congenital microtia. After the first stage of delaying the postauricular skin flap and the second stage of otoplasty with ear framework fabricated from autogenous rib cartilage draping with the delayed skin flap, the third stage involved tragus and external auditory meatus canaloplasty...
April 2018: Facial Plastic Surgery: FPS
https://www.readbyqxmd.com/read/29427545/evaluation-of-decellularized-xenogenic-porcine-auricular-cartilage-as-a-novel-biocompatible-filler
#18
Sung-Chan Shin, Hee Young Park, Nari Shin, Da-Woon Jung, Hyun-Keun Kwon, Ji Min Kim, Soo-Geun Wang, Jin-Choon Lee, Eui-Suk Sung, Gi Cheol Park, Byung-Joo Lee
Fillers are products that fill the space in soft tissues of the human body and actively used in the various medical fields. Unfortunately, most of the cost-effective commercially available fillers are synthetic and have limitations in terms of their biocompatibility. Here, we evaluated the possible application of decellularized xenogenic cartilage as a long-lasting material for soft tissue augmentation and compared it with two commercially available fillers Artesense (polymethylmethacrylate microspheres) and Radiesse (calcium hydroxyapatite [CaHa])...
February 10, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29419592/refinements-in-elevation-of-the-reconstructed-auricle-the-zigzag-incision
#19
So-Eun Han, Yeseul Eom, Kap Sung Oh
OBJECTIVE: Auricular elevation with superficial temporal fascia and skin graft is widely used in microtia reconstruction using costal cartilage. However, in some patients, there has been occurrence of contraction of skin graft, which led to insufficient projection of the elevated auricle and diminished auriculocephalic angle with unfavorable long-term results. In this article, the authors introduce their multiple triangular flaps with zigzag incision to maintain stable projection and natural retroauricular sulcus appearance in auricular reconstruction patients...
February 6, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29396297/in-vitro-regeneration-of-patient-specific-ear-shaped-cartilage-and-its-first-clinical-application-for-auricular-reconstruction
#20
Guangdong Zhou, Haiyue Jiang, Zongqi Yin, Yu Liu, Qingguo Zhang, Chen Zhang, Bo Pan, Jiayu Zhou, Xu Zhou, Hengyun Sun, Dan Li, Aijuan He, Zhiyong Zhang, Wenjie Zhang, Wei Liu, Yilin Cao
Microtia is a congenital external ear malformation that can seriously influence the psychological and physiological well-being of affected children. The successful regeneration of human ear-shaped cartilage using a tissue engineering approach in a nude mouse represents a promising approach for auricular reconstruction. However, owing to technical issues in cell source, shape control, mechanical strength, biosafety, and long-term stability of the regenerated cartilage, human tissue engineered ear-shaped cartilage is yet to be applied clinically...
February 2018: EBioMedicine
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