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Auricular cartilage

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https://www.readbyqxmd.com/read/29139602/cell-yield-chondrogenic-potential-and-regenerated-cartilage-type-of-chondrocytes-derived-from-ear-nasoseptal-and-costal-cartilage
#1
Aijuan He, Huitang Xia, Kaiyan Xiao, Tingting Wang, Yu Liu, Jixin Xue, Dan Li, Shengjian Tang, Fangjun Liu, Xiaoyun Wang, Wenjie Zhang, Wei Liu, Yilin Cao, Guangdong Zhou
Functional reconstruction of large cartilage defects in subcutaneous sites remains clinically challenging because of limited donor cartilage. Tissue engineering is a promising and widely accepted strategy for cartilage regeneration. To date however, this strategy has not achieved a significant breakthrough in clinical translation owing to a lack of detailed pre-clinical data on cell yield and functionality of clinically applicable chondrocytes. To address this issue, the current study investigated the initial cell yield, proliferative potential, chondrogenic capacity, and regenerated cartilage-type of human chondrocytes derived from auricular (AU), nasoseptal (NS), and costal (CO) cartilage using a scaffold-free cartilage regeneration model (cartilage sheet)...
November 15, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29135862/management-of-sigmoid-sinus-associated-pulsatile-tinnitus-a-systematic-review-of-the-literature
#2
Alan C Wang, Avery N Nelson, Cassandra Pino, Peter F Svider, Robert S Hong, Eleanor Chan
OBJECTIVES: Although studies demonstrate 4 to 20% of patients with pulsatile tinnitus (PT) have associated sigmoid sinus anomalies, no consensus exists regarding optimal management. Our objective was to perform a systematic review exploring surgical and endovascular intervention of PT caused by sigmoid sinus anomalies. DATA SOURCES/EXTRACTION: A systematic review was performed using the Preferred Reporting Systems for Systematic Reviews and Meta-Analysis guidelines for reporting of results, with a target population encompassing patients with PT and either sigmoid sinus diverticulum or sigmoid wall dehiscence...
December 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/29126262/relapsing-polychondritis-a-clinical-review-for-rheumatologists
#3
Jack Kingdon, Joseph Roscamp, Shirish Sangle, David D'Cruz
Relapsing polychondritis (RPC) is a rare autoimmune rheumatic disorder that is traditionally classified as a systemic vasculitis. It is characterized by inflammation of cartilage, and typical presenting features include chondritis of the nasal bridge, auricular chondritis, ocular inflammation and involvement of the bronchial tree. Its rarity often leads to considerable delay in establishing a diagnosis and poses a significant management challenge to clinicians, as no conventional guidelines exist. This review summarizes the clinical features of RPC and provides guidance for rheumatologists on making the diagnosis and assessing organ involvement...
November 6, 2017: Rheumatology
https://www.readbyqxmd.com/read/29090195/histological-physical-studies-after-xenograft-of-porcine-ear-cartilage
#4
Yong Ah Ryu, Meiying Jin, Nakheon Kang
BACKGROUND: Because of the relatively similar size of organs to human and the physiological and structural similarities, the use of porcine as xenograft donors is progressing very actively. In this study, we analyzed the characteristics of porcine ear cartilage and evaluated its suitability as graft material in reconstructive and cosmetic surgery. METHODS: The auricular cartilage was harvested from two pigs, and subjected to histological examination by immunohistochemical staining...
September 2017: Arch Craniofac Surg
https://www.readbyqxmd.com/read/29078705/comparisons-of-auricular-cartilage-tissues-from-different-species
#5
COMPARATIVE STUDY
Loraine L Y Chiu, Renata Giardini-Rosa, Joanna F Weber, Sharon L Cushing, Stephen D Waldman
OBJECTIVES: Tissue engineering of auricular cartilage has great potential in providing readily available materials for reconstructive surgeries. As the field of tissue engineering moves forward to developing human tissues, there needs to be an interspecies comparison of the native auricular cartilage in order to determine a suitable animal model to assess the performance of engineered auricular cartilage in vivo. METHODS: Here, we performed interspecies comparisons of auricular cartilage by comparing tissue microstructure, protein localization, biochemical composition, and mechanical properties of auricular cartilage tissues from rat, rabbit, pig, cow, and human...
December 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/29045420/inhibition-of-apoptosis-signal-regulating-kinase-1-alters-the-wound-epidermis-and-enhances-auricular-cartilage-regeneration
#6
Qian-Shi Zhang, Deepa S Kurpad, My G Mahoney, Marla J Steinbeck, Theresa A Freeman
Why regeneration does not occur in mammals remains elusive. In lower vertebrates, epimorphic regeneration of the limb is directed by the wound epidermis, which controls blastema formation to promote regrowth of the appendage. Herein, we report that knockout (KO) or inhibition of Apoptosis Signal-regulated Kinase-1 (ASK1), also known as mitogen-activated protein kinase kinase kinase 5 (MAP3K5), after full thickness ear punch in mice prolongs keratinocyte activation within the wound epidermis and promotes regeneration of auricular cartilage...
2017: PloS One
https://www.readbyqxmd.com/read/29040358/tissue-expansion-using-hyaluronic-acid-filler-for-single-stage-ear-reconstruction-a-novel-concept-for-difficult-areas
#7
Amir Inbal, Benjamin T Lemelman, Eran Millet, Andrew Greensmith
Background: Auricular reconstruction is one of the most challenging procedures in plastic surgery. An adequate skin envelope is essential for cartilage framework coverage, yet few good options exist without additional surgery. We propose a novel method for minimally invasive tissue expansion, using hyaluronic acid (HA) filler to allow for single-stage ear reconstruction. Objectives: To introduce the novel concept of HA filler for tissue expansion in ear reconstruction, and as an alternative to traditional expansion techniques...
October 16, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29019876/unique-circumferential-peripheral-keratitis-in-relapsing-polychondritis-a-case-report
#8
Naohiro Motozawa, Takahiro Nakamura, Seiji Takagi, Masashi Fujihara, Yasuhiko Hirami, Kazuhiro Ishida, Chie Sotozono, Yasuo Kurimoto
RATIONALE: Relapsing polychondritis (RP) is a rare collagen disease characterized by inflammation and destruction of cartilage throughout the body. The paper details the clinical course of a case of RP with unique circumferential peripheral keratitis. PATIENT CONCERNS: A 54-year-old Japanese woman was referred to the hospital presenting with auricular and ocular pain. DIAGNOSES: Based on the auricle biopsy results and the three presenting symptoms (bilateral auricular chondritis, inflammatory arthritis and ocular inflammation), her condition was diagnosed as RP...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28953580/relapsing-polychondritis-with-increased-bone-marrow-signal-on-magnetic-resonance-imaging-in-a-13-year-old-girl
#9
Kanako Nakayama, Masafumi Yamada, Yusuke Tozawa, Yuji Nakamaru, Masahiro Ueki, Shunichiro Takezaki, Hiroki Nishimura, Tomoko Mitsuhashi, Noriko Oyama-Manabe, Keita Sakamoto, Ryuta Arai, Sayaka Yamamoto, Kimiaki Uetake, Tadashi Ariga
Relapsing polychondritis (RPC) is an inflammatory disorder predominantly affecting cartilaginous structures including ears, nose, joints, and respiratory tracts. Although RPC is rare in children, previous reports indicated childhood RPC is atypical or severe. A 13-year-old girl presented with redness and swelling of the bilateral auricles and subsequently developed arthralgia of multiple joints. Histopathologic findings of the auricular cartilages were compatible with RPC. Magnetic resonance imaging (MRI) for the evaluation of arthralgia unexpectedly demonstrated increased bone marrow signal of metacarpals and the distal epiphysis of radii and ulnae...
September 26, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28938361/columellar-reconstruction-following-nasal-cpap-injury
#10
Catherine S Chang, Jordan W Swanson, Anthony Wilson, David W Low, Scott P Bartlett
Nasal continuous positive airway pressure (nCPAP) is utilized increasingly to treat pulmonary immaturity in premature neonates. Nasal injury is common with nCPAP use, with full thickness tissue loss at the columella among the most devastating complications.Columellar necrosis often imparts a full thickness injury to the overlying columellar skin, the medial crura of the lower lateral nasal cartilages, as well as the anteromedial inner nasal mucosal lining, and potentially the anterior septal cartilage. Consequently, the columella can become scarred and shortened...
September 15, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28938313/a-novel-three-step-method-for-correction-of-type-1-stahl-ear
#11
Mimi R Borrelli, Edward H Davidson, Anand R Kumar
BACKGROUND: Stahl ear, a rare congenital auricular anomaly, occurs when a third crus crosses the scaphoid fossa. Optimal elimination of the third crus and reconstruction the superior crus in type 1 Stahl ear remain undercharacterized. We present a novel 3-step technique to reliably correct a type 1 Stahl ear as a case report. METHODS: A 10-year-old male with bilateral prominent type 1 Stahl ears is presented. An anterior curvilinear helical fold incision and posterior V wedge excision was used for exposure...
November 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28872513/reconstruction-of-orbital-floor-with-auricular-concha
#12
Ergin Seven, Ali Teoman Tellioglu, Emre Inozu, Hulda Rifat Ozakpinar, Ugur Horoz, Avni Tolga Eryilmaz, Sebat Karamursel
Orbital floor fractures of varying sizes commonly occur after orbital injuries and remain a serious challenge. Serious complications of such fractures include enopthalmos, restriction of extraocular movement, and diplopia. There is a dearth of literature that can be applied widely, easily, and successfully in all such situations, and therefore there is no consensus on the treatment protocol of this pathology yet. Autogenous grafts and alloplastic and allogenic materials with a wide variety of advantages and disadvantages have been discussed...
October 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28846132/age-related-histologic-and-biochemical-changes-in-auricular-and-septal-cartilage
#13
Kiersten L Riedler, Alireza Shokrani, Alexander Markarian, Laurel M Fisher, Jon-Paul Pepper
OBJECTIVES/HYPOTHESIS: To characterize the histologic and biochemical properties of auricular and septal cartilage and analyze age-related changes in middle-aged to older adults. STUDY DESIGN: Cross-sectional study of auricular and septal cartilage from 33 fresh cadavers. METHODS: Auricular and septal cartilage specimens were stained using Safranin O for glycosaminoglycans, Verhoeff's stain for elastin, and Masson's trichrome for collagen...
November 2017: Laryngoscope
https://www.readbyqxmd.com/read/28844147/costal-and-auricular-cartilage-grafts-for-nasal-reconstruction-an-anatomic-analysis
#14
Thuy-Van Tina Ho, Thomas Cochran, Kevin J Sykes, Clinton D Humphrey, J David Kriet
OBJECTIVES: The aim of this study was to measure the length, width, and surface area of costal and auricular cartilage harvested for grafting in rhinoplasty and nasal reconstruction. We also compared the sizes of ear cartilage grafts harvested from the anterior and posterior approaches. METHODS: Fifty-eight nasal reconstructive surgeries requiring rib or ear cartilage were performed by 2 facial plastic surgeons from February 2015 through January 2016. Among the 57 cases that met inclusion criteria, they comprised of 33 costal cartilage grafts and 24 auricular cartilage grafts (17 via anterior approach and 7 via posterior approach)...
October 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/28834348/clinical-images-relapsing-polychondritis-diagnosed-by-fusion-images-of-gallium-67-uptake-on-computed-tomography-and-single-photon-emission-computed-tomography
#15
Kazuhisa Nakano, Takafumi Aritomi, Naoaki Ohkubo, Yoshiya Tanaka
No abstract text is available yet for this article.
August 22, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28798549/autologous-ear-reconstruction
#16
REVIEW
Asaf Olshinka, Matthew Louis, Tuan A Truong
Since the pioneering use of autologous rib cartilage for the reconstruction of microtia, there have been significant advances in surgical technique that have helped to ameliorate the psychological burden of microtia. To date, the use of rib cartilage for auricular reconstruction is one of the most enduring and ubiquitous techniques for microtia reconstruction as it provides excellent aesthetic results with lasting durability. In this review, the authors outline the most common methods of microtia reconstruction with a comparison of each technique and illustrative case examples...
August 2017: Seminars in Plastic Surgery
https://www.readbyqxmd.com/read/28796097/comparison-of-two-different-grafts-in-nasal-framework-reconstruction-of-binder-syndrome-cartilage-and-silicone
#17
Le Tian, Jianjun You, Huan Wang, Bo Zhang, Yihao Xu, Xiaona Lu, Fei Fan
BACKGROUND: Binder syndrome is a rare congenital malformation with a flat facial profile especially a depressed nose. Rhinoplasty plays an important part in the multidisciplinary surgical protocol. Different materials have been proposed to reconstruct nasal framework. But fewer evidence concerns which graft can achieve more stable and appreciated nasal contour. In this article, the authors reported surgical details and experience of nasal framework reconstruction of Binder syndrome, compare the esthetic outcomes of 2 grafts: autologous costal cartilage and L-shaped silicone covered with auricular cartilage...
September 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28777314/artificial-auricular-cartilage-using-silk-fibroin-and-polyvinyl-alcohol-hydrogel
#18
Jung Min Lee, Md Tipu Sultan, Soon Hee Kim, Vijay Kumar, Yeung Kyu Yeon, Ok Joo Lee, Chan Hum Park
Several methods for auricular cartilage engineering use tissue engineering techniques. However, an ideal method for engineering auricular cartilage has not been reported. To address this issue, we developed a strategy to engineer auricular cartilage using silk fibroin (SF) and polyvinyl alcohol (PVA) hydrogel. We constructed different hydrogels with various ratios of SF and PVA by using salt leaching, silicone mold casting, and freeze-thawing methods. We characterized each of the hydrogels in terms of the swelling ratio, tensile strength, pore size, thermal properties, morphologies, and chemical properties...
August 4, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28746277/auricular-tissue-engineering-using-osteogenic-differentiation-of-adipose-stem-cells-with-small-intestine-submucosa
#19
Chih-Hsun Lin, I-Chen Yang, Chi-Han Tsai, Hsu-Wei Fang, Hsu Ma
BACKGROUND: Ear reconstruction remains a challenge for plastic surgeons. A tissue-engineering approach could provide another route for obtaining shape maintenance in neoauricular tissue. METHODS: The authors designed a novel tissue-engineering auricular construct by culturing human adipose stem cells, which differentiated into osteocytes but not chondrocytes, in small intestine submucosa scaffolds. The authors evaluated cell growth potential and mechanical properties...
August 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28692518/costal-cartilage-assessment-in-surgical-timing-of-microtia-reconstruction
#20
Zhongyang Sun, Xiaobo Yu, Weiwei Chen, Qinghua Yang, Yupeng Song, Jiayu Zhou, Haiyue Jiang
BACKGROUND: Rib cartilage growth is closely related to age and determines the feasibility and outcomes of auricular reconstruction. Ear reconstruction is performed as early as age 6 in efforts to treat children before school matriculation while allowing for sufficient rib growth. But there is controversy over the optimal timing of microtia reconstruction. This study employs CT imaging and surface scanning to guide the timing of auricular reconstruction in children. METHODS: A retrospective analysis was performed on 6-year-old microtia patients between January 2016 and June 2016...
September 2017: Journal of Craniofacial Surgery
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