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Auricular cartilage

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https://www.readbyqxmd.com/read/28640533/high-risk-squamous-cell-carcinoma-of-the-ear-a-potential-role-for-sentinel-node-biopsy
#1
Suzanne Beecher, Paula F Wrafter, Cormac W Joyce, Padraic J Regan, Jack L Kelly
BACKGROUND: Squamous cell carcinomas (SCCs) of the external ear have a significant rate of metastasis. The purpose of this study was to present analyzed factors associated with auricular SCC metastasis in order to identify a group that may benefit from sentinel lymph node biopsy (SLNB). METHODS: We performed a retrospective review of all operable SCCs between 2009 and 2014. The association between high-risk features and metastasis were analyzed. RESULTS: One hundred eighty-nine auricular SCCs were excised...
June 22, 2017: Head & Neck
https://www.readbyqxmd.com/read/28583280/clinical-value-of-fdg-pet-ct-for-the-evaluation-of-rheumatic-diseases-rheumatoid-arthritis-polymyalgia-rheumatica-and-relapsing-polychondritis
#2
REVIEW
Kazuo Kubota, Hiroyuki Yamashita, Akio Mimori
FDG is a tracer for visualizing glucose metabolism. PET/CT using FDG is widely used for the diagnosis of cancer, because glycolysis is elevated in cancer cells. Similarly, active inflammatory tissue also exhibits elevated glucose metabolism because of glycolysis in activated macrophages and proliferating fibroblasts. Elevated FDG uptake by active inflammatory tissues, such as those affected by arthritis, vasculitis, lymphadenitis, and chondritis, has enabled the diagnosis of inflammatory diseases using FDG-PET/CT...
July 2017: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/28574571/roles-of-macrophage-migration-inhibitory-factor-in-cartilage-tissue-engineering
#3
Yuko Fujihara, Atsuhiko Hikita, Tsuyoshi Takato, Kazuto Hoshi
To obtain stable outcomes in regenerative medicine, understanding and controlling immunological responses in transplanted tissues are of great importance. In our previous study, auricular chondrocytes in tissue-engineered cartilage transplanted in mice were shown to express immunological factors, including macrophage migration inhibitory factor (MIF). Since MIF exerts pleiotropic functions, in this study, we examined the roles of MIF in cartilage regenerative medicine. We made tissue-engineered cartilage consisting of auricular chondrocytes of C57BL/6J mouse, atellocollagen gel and a PLLA scaffold, and transplanted the construct subcutaneously in a syngeneic manner...
June 2, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28552866/meningeal-plasma-cell-granuloma-in-the-early-stage-of-relapsing-polychondritis
#4
Shintaro Hayashi, Norihiko Akao, Koichi Okamoto
A 77-year-old man showed an asymptomatic meningeal lesion beneath the dura matter in the left fronto-parietal region on MRI during an examination for recurrent hoarsness. The lesion showed no gadolinium enhancement, and extended to neither the sulci nor skull. Neurological examinations revealed hoarseness, cochlear and vestibular dysfunction of the right ear, and mildly decreased Achilles tendon reflexes bilaterally. Laboratory findings showed marked inflammatory responses, but no abnormalities for LDH, IgG4, angiotensin-converting enzyme, or soluble IL-2 receptor...
May 26, 2017: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/28539839/ppard-is-an-inhibitor-of-cartilage-growth-in-external-ears
#5
Zhen Zhang, Yanyu Duan, Zhongping Wu, Hui Zhang, Jun Ren, Lusheng Huang
Peroxisome proliferator-activated receptor beta/delta (PPARD) is an important determinant of multiple biological processes. Our previous studies identified a missense mutation in the PPARD gene that significantly reduces its transcription activity, and consequently causes enlarged external ears in pigs. However, the mechanisms underlying the causality has remained largely unknown. Here, we show that PPARD retards the development of auricular cartilage by accelerating the apoptosis of cartilage stem/progenitor cells (CSPCs), the terminal differentiation of cartilage cells and the degradation of cartilage extracellular matrix in the auricle...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28524733/cartilage-engineering-in-reconstructive-surgery-auricular-nasal-and-tracheal-engineering-from-a-surgical-perspective
#6
Paul Severin Wiggenhauser, Jan Thorsten Schantz, Nicole Rotter
This review provides an update on cartilage tissue engineering with particular focus on the head and neck. It is aimed at scientists and clinicians who are interested in tissue engineering and its clinical applicability. Principal tissue engineering strategies are summarized in the first part of this review. In the second part, current clinical approaches to auricular, nasal and tracheal reconstruction are discussed from a surgical perspective. By this approach, the requirements for clinical applicability are outlined and new insight into relevant aims of research is given to accelerate the transfer from bench to bedside...
May 19, 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/28493212/composite-bioscaffolds-incorporating-decellularized-ecm-as-a-cell-instructive-component-within-hydrogels-as-in-vitro-models-and-cell-delivery-systems
#7
Arthi Shridhar, Elizabeth Gillies, Brian G Amsden, Lauren E Flynn
Decellularized tissues represent promising biomaterials, which harness the innate capacity of the tissue-specific extracellular matrix (ECM) to direct cell functions including stem cell proliferation and lineage-specific differentiation. However, bioscaffolds derived exclusively from decellularized ECM offer limited versatility in terms of tuning biomechanical properties, as well as cell-cell and cell-ECM interactions that are important mediators of the cellular response. As an alternative approach, in the current chapter we describe methods for incorporating cryo-milled decellularized tissues as a cell-instructive component within a hydrogel carrier designed to crosslink under mild conditions...
May 11, 2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28462782/regeneration-of-subcutaneous-tissue-engineered-mandibular-condyle-in-nude-mice
#8
Feiyu Wang, Yihui Hu, Dongmei He, Guangdong Zhou, Xiujuan Yang, Edward Ellis
PURPOSE: To explore the feasibility of regenerating mandibular condyles based on cartilage cell sheet with cell bone-phase scaffold compared with cell-biphasic scaffolds. MATERIALS AND METHODS: Tissue-engineered mandibular condyles were regenerated by the following: 1) cartilage cell sheet + bone-phase scaffold (PCL/HA) seeded with bone marrow stem cells (BMSCs) from minipigs (cell sheet group), and 2) cartilage phase scaffold (PGA/PLA) seeded with auricular chondrocytes + bone-phase scaffold seeded with BMSCs from minipigs (biphasic scaffold group)...
June 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28445373/auricular-reconstruction-in-hemifacial-microsomia-with-an-expanded-two-flap-method
#9
Jin Qian, Zhibin Li, Tun Liu, Xu Zhou, Qingguo Zhang
BACKGROUND: Reconstruction of external ear is important for the child/adult with craniofacial deformities to achieve balance and harmony of the face and head. The aim of this study was to investigate the clinical application of an expanded two-flap method for auricular reconstruction in hemifacial microsomia. METHODS: Between January of 2014 and November of 2015, 111 hemifacial microsomia patients with microtia underwent auricular reconstruction with an expanded two-flap method...
May 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28445368/correcting-concavity-of-rabbit-auricular-cartilage-comparison-of-single-scoring-incisions-with-butyl-cyanoacrylate-aided-techniques
#10
Yalcin Yontar, İrfan Özyazgan
BACKGROUND: The authors present the results of an experimental study in which four different techniques were used for the correction of concave rabbit auricular cartilage. METHODS: Sixteen New Zealand adult male rabbits were used in the study. Butyl cyanoacrylate-aided cartilage graft fixation and butyl cyanoacrylate-aided bone graft fixation and scoring technique, alone or combined with butyl cyanoacrylate application, were performed to correct the concavity of rabbit auricular cartilage...
May 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28430334/chondro-keratoprosthesis-an-alternative-to-ookp
#11
Louis Hoffart, Laurent Guyot
PURPOSE: To evaluate the use of cartilage as a potential graft material toward osteo-odontal tissue replacement in keratoprosthesis surgery. METHODS: We describe a modification of the osteo-odonto-keratoprosthesis surgery that involves the use of autologous auricular conchal cartilage graft (ACCG). In stage 1a, a full-thickness cheek mucosa graft was performed over the ocular surface. In stage 1b, ACCG was harvested via a retroauricular approach. An optical polymethyl-methacrylate cylinder was embedded into a double-layered fragment of cartilage and secured by cyanoacrylate glue...
April 4, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28396871/innervation-of-the-human-cavum-conchae-and-auditory-canal-anatomical-basis-for-transcutaneous-auricular-nerve-stimulation
#12
P Bermejo, M López, I Larraya, J Chamorro, J L Cobo, S Ordóñez, J A Vega
The innocuous transcutaneous stimulation of nerves supplying the outer ear has been demonstrated to be as effective as the invasive direct stimulation of the vagus nerve for the treatment of some neurological and nonneurological disturbances. Thus, the precise knowledge of external ear innervation is of maximal interest for the design of transcutaneous auricular nerve stimulation devices. We analyzed eleven outer ears, and the innervation was assessed by Masson's trichrome staining, immunohistochemistry, or immunofluorescence (neurofilaments, S100 protein, and myelin-basic protein)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28352607/a-new-technique-for-conchal-cartilage-harvest
#13
Joon Young Kim, Ho Jik Yang, Ji Won Jeong
The goal of auricular cartilage harvest is to obtain a sufficient amount for reconstruction and to minimize the change in ear shape. The cartilage can be harvested by a posterior or anterior approach, and each method has advantages and disadvantages. The posterior approach presents the advantage of scar concealment, but there are limits to the amount of cymba cartilage that may be harvested. In contrast, the anterior approach may cause a noticeable scar. However, as cartilage is collected, the anterior approach provides a view that facilitates the preservation ear structure...
March 2017: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/28350674/a-new-microtia-reconstruction-method-using-delayed-postauricular-skin-flap
#14
Gaofeng Li, Fan Zhang, Wei Ding, Zihan Wu, Yigao Hu, Tao Luo, Bo Zhang, Xia Jiang
BACKGROUND: This article presents a new microtia reconstruction method using a delayed postauricular skin flap. METHODS: The surgery is scheduled in three stages, the first of which delays the postauricular skin flap and deals with the remnant auricle. Three weeks later, the second stage is carried out. An erect, three-dimensional ear framework fabricated from autogenous rib cartilage is inserted between two flaps. The anterior auricular surface of the framework is draped with the delayed skin flap, and the postauricular surface is draped with postauricular fascia and overlying grafted skin...
April 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28350666/long-term-comparison-between-human-normal-conchal-and-microtia-chondrocytes-regenerated-by-tissue-engineering-on-nanofiber-polyglycolic-acid-scaffolds
#15
COMPARATIVE STUDY
Hitomi Nakao, Robin D Jacquet, Mark Shasti, Noritaka Isogai, Ananth S Murthy, William J Landis
BACKGROUND: Previous regeneration studies of auricle-shaped cartilage by tissue engineering leave unresolved whether the chondrocyte phenotype from human auricular chondrocytes seeded onto polymeric scaffolds is retained over the long term and whether microtia remnants may be a viable cell source for auricular reconstruction. METHODS: Chondrocytes were isolated from human ears, either normal conchal ear or microtia cartilage remnants, expanded in vitro, and seeded onto nanoscale-diameter polyglycolic acid sheets...
April 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28341947/the-versatile-posterior-auricular-fascia-in-secondary-rhinoplasty-procedures
#16
Darryl James Hodgkinson, Pedro Miguel Valente
BACKGROUND: Secondary rhinoplasty often involves the addition of autogenous graft material to add volume, structure, support and to camouflage cartilage and bone grafts. A variety of fascias have been used to camouflage, wrap and give "fill" in secondary rhinoplasty. The posterior auricular fascia is a source of material ideal for such purposes, and its quantity, anatomical structure and ease of harvest with minimal donor site morbidity make it a versatile and attractive autogenous graft...
March 24, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28293505/accurate-measurements-of-the-skin-surface-area-of-the-healthy-auricle-and-skin-deficiency-in-microtia-patients
#17
Iris A Otto, Rob F M van Doremalen, Ferry P W Melchels, Michail N Kolodzynski, Behdad Pouran, Jos Malda, Moshe Kon, Corstiaan C Breugem
BACKGROUND: The limited cranial skin covering auricular implants is an important yet underrated factor in auricular reconstruction for both reconstruction surgery and tissue engineering strategies. We report exact measurements on skin deficiency in microtia patients and propose an accessible preoperative method for these measurements. METHODS: Plaster ear models (n = 11; male:female = 2:1) of lobular-type microtia patients admitted to the University Medical Center Utrecht in The Netherlands were scanned using a micro-computed tomographic scanner or a cone-beam computed tomographic scanner...
December 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28280656/noninvasive-measurement-of-ear-cartilage-elasticity-on-the-cellular-level-a-new-method-to-provide-biomechanical-information-for-tissue-engineering
#18
Ernst Jan Bos, Koen van der Laan, Marco N Helder, Margriet G Mullender, Davide Iannuzzi, Paul P van Zuijlen
BACKGROUND: An important feature of auricular cartilage is its stiffness. To tissue engineer new cartilage, we need objective tools to provide us with the essential biomechanical information to mimic optimal conditions for chondrogenesis and extracellular matrix (ECM) development. In this study, we used an optomechanical sensor to investigate the elasticity of auricular cartilage ECM and tested whether sensitivity and measurement reproducibility of the sensor would be sufficient to accurately detect (subtle) differences in matrix compositions in healthy, diseased, or regenerated cartilage...
February 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28272149/plasticity-of-auricular-cartilage-in-response-to-hormone-therapy
#19
Patrick S Cottler, Matthew D McLeod, Jesse I Payton, Angela Pineros-Fernandez, Jonathan S Black
INTRODUCTION: Correction of auricular deformities can be accomplished through splinting within the first few weeks of life. This is hypothesized to be due to retained circulating maternal estrogens decreasing the structural density of collagen; however, this has not been fully tested. Cartilage elasticity is dependent on the concentration of the proteoglycan aggregate, and hyaluronic acid, a constituent of proteoglycan aggregate, is increased by estrogens. Nonsurgical correction of these deformities in more developed patients has the potential to change clinical practice and eliminate surgical risks...
June 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28266051/relapsing-polychondritis-associated-with-psoriasis-vulgaris-successfully-treated-with-adalimumab-a-case-report-with-published-work-review
#20
Haruka Matsuo, Akihiko Asahina, Takeshi Fukuda, Yoshinori Umezawa, Hidemi Nakagawa
Relapsing polychondritis (RP) is a rare autoimmune-mediated disease characterized by inflammation involving cartilaginous tissues. We report here a case of RP in a 38-year-old Japanese man with 13-year duration of psoriasis vulgaris treated with topical steroids and vitamin D3 . The patient presented with tender swelling and erythema of both auricles, and the antibody to type II collagen was detected. The biopsy specimen revealed a dense mixed cell infiltration over the auricular cartilage. We reviewed eight cases with the association of RP and psoriasis, and in all cases the clinical course of psoriasis did not correlate with that of RP...
March 7, 2017: Journal of Dermatology
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