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Bilateral breast cancer

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https://www.readbyqxmd.com/read/29786129/surgeon-variability-and-factors-predicting-for-reoperation-following-breast-conserving-surgery
#1
Monica G Valero, Melissa Anne Mallory, Katya Losk, Mustafa Tukenmez, Jaeho Hwang, Kristen Camuso, Craig Bunnell, Tari King, Mehra Golshan
BACKGROUND: Reoperation after breast-conserving surgery (BCS) is common and has been partially associated with the lack of consensus on margin definition. We sought to investigate factors associated with reoperations and variation in reoperation rates across breast surgeons at our cancer center. METHODS: Retrospective analyses of patients with clinical stage I-II breast cancer who underwent BCS between January and December 2014 were conducted prior to the recommendation of 'no ink on tumor' margin...
May 21, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29778821/evaluating-mastectomy-skin-flap-necrosis-in-the-extended-breast-reconstruction-risk-assessment-score-for-one-year-prediction-of-prosthetic-reconstruction-outcomes
#2
Nora Hansen, Sasa Espino, Jordan T Blough, Michael M Vu, Neil A Fine, John Ys Kim
BACKGROUND: Rates of mastectomy for breast cancer treatment and immediate reconstruction continue to rise. With increasing scrutiny on outcomes and patient satisfaction, there is an impetus for providers to be more deliberate in deciding appropriate patient selection for breast reconstruction. The Breast Reconstruction Risk Assessment (BRA) Score was developed for prediction of complications after primary prosthetic breast reconstruction, focusing on calculating risk estimations for a variety of complications based on individual patient demographics and perioperative characteristics...
May 17, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29777149/stretching-reduces-tumor-growth-in-a-mouse-breast-cancer-model
#3
L Berrueta, J Bergholz, D Munoz, I Muskaj, G J Badger, A Shukla, H J Kim, J J Zhao, H M Langevin
There is growing interest in developing non-pharmacological treatments that could boost natural defenses against cancer and contribute to primary and secondary cancer prevention. Recent studies have shown that gentle daily stretching for 10 minutes can reduce local connective tissue inflammation and fibrosis. Because mechanical factors within the stroma can influence the tumor microenvironment, we hypothesized that stretching would reduce the growth of tumors implanted within locally stretched tissues and tested this hypothesis in a mouse orthotopic breast cancer model...
May 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29774317/frequency-of-rearrangements-versus-small-indels-mutations-in-brca1-and-brca2-genes-in-turkish-patients-with-high-risk-breast-and-ovarian-cancer
#4
Hülya Yazıcı, Seda Kılıç, Demet Akdeniz, Özge Şükrüoğlu, Şeref Buğra Tuncer, Mukaddes Avşar, Gözde Kuru, Betül Çelik, Seden Küçücük, Pınar Saip
Objective: The current rearrangement ratio of BRCA1 and BRCA2 genes is not known in the Turkish population. Rearrangements are not routinely investigated in many Turkish laboratories. This creates problems and contradictions between clinics. Therefore, the aim of this study was to evaluate the distribution and frequency of rearrangements in BRCA1 and BRCA2 genes in high-risk families and to clarify the limits of BRCA1 and BRCA2 testing in Turkey. Materials and Methods: The study included 1809 patients at high risk of breast cancer or ovarian cancer...
April 2018: European Journal of Breast Health
https://www.readbyqxmd.com/read/29774312/breast-cancer-prevention-current-approaches-and-future-directions
#5
REVIEW
Edward R Sauter
The topic of breast cancer prevention is very broad. All aspects of the topic, therefore, cannot be adequately covered in a single review. The objective of this review is to discuss strategies in current use to prevent breast cancer, as well as potential approaches that could be used in the future. This review does not discuss early detection strategies for breast cancer, including breast cancer screening. The breast is the most common site among women worldwide of noncutaneous cancer. Many clinical and genetic factors have been found to increase a woman's risk of developing the disease...
April 2018: European journal of breast health
https://www.readbyqxmd.com/read/29772993/shoulder-lesion-in-a-69-year-old-woman
#6
Andrew J Hayden, Srinivas Kolla, Adele L Boskey, Steven Burekhovich, Chuanyong Lu, Michael Stracher, Aditya V Maheshwari
Milwaukee Shoulder Syndrome (MSS) is a painful progressive arthropathy in which hydroxyapatite crystal deposition in synovial tissue induces lysosomal release of collagenase and neutral proteases. These enzymes are destructive to periarticular tissue, including the synovium, articular cartilage, rotator cuff muscles, and the intrasynovial cortical bone. MSS predominantly occurring in women (90%) over the age of 70 years of age with a clinical history marked by recurrent joint effusions and pain, which classically worsens at night...
2018: Journal of Long-term Effects of Medical Implants
https://www.readbyqxmd.com/read/29763969/hormone-replacement-therapy-for-women-previously-treated-for-endometrial-cancer
#7
REVIEW
Katharine A Edey, Stuart Rundle, Martha Hickey
BACKGROUND: Endometrial cancer is the sixth most common cancer in women worldwide and most commonly occurs after the menopause (75%) (globocan.iarc.fr). About 319,000 new cases were diagnosed worldwide in 2012. Endometrial cancer is commonly considered as a potentially 'curable cancer,' as approximately 75% of cases are diagnosed before disease has spread outside the uterus (FIGO (International Federation of Gynecology and Obstetrics) stage I). The overall five-year survival for all stages is about 86%, and, if the cancer is confined to the uterus, the five-year survival rate may increase to 97%...
May 15, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29762441/a-risk-stratified-comparison-of-high-risk-findings-in-reduction-mammoplasty
#8
Stephanie E Dreifuss, Angela S Landfair, Carolyn De La Cruz
BACKGROUND: Reduction mammoplasty is indicated for symptomatic macromastia or breast asymmetry after contralateral cancer surgery. Previous studies compared the incidence of high-risk lesions in resection specimens between these 2 groups. However, no studies have compared incidental findings in breast reduction specimens based on relative risk of cancer. Our study stratifies lesions by relative risk of malignant progression and compares the frequency of these findings in bilateral versus unilateral reduction mammoplasties...
May 14, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29761322/concurrent-risk-reduction-surgery-in-patients-with-increased-lifetime-risk-for-breast-and-ovarian-cancer-an-analysis-of-the-national-surgical-quality-improvement-program-nsqip-database
#9
Maryam Elmi, Arash Azin, Ahmad Elnahas, David R McCready, Tulin D Cil
BACKGROUND: Patients with genetic susceptibility to breast and ovarian cancer are eligible for risk-reduction surgery. Surgical morbidity of risk-reduction mastectomy (RRM) with concurrent bilateral salpingo-oophorectomy (BSO) is unknown. Outcomes in these patients were compared to patients undergoing RRM without BSO using a large multi-institutional database. METHODS: A retrospective cohort analysis was conducted using the American College of Surgeon's National Surgical Quality Improvement Program (NSQIP) 2007-2016 datasets, comparing postoperative morbidity between patients undergoing RRM with patients undergoing RRM with concurrent BSO...
May 14, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29758504/patients-perspectives-and-experiences-concerning-barriers-to-accessing-information-about-bilateral-prophylactic-mastectomy
#10
Rachael Glassey, Moira O'Connor, Angela Ives, Christobel Saunders, kConFab Investigators, Sarah O'Sullivan, Sarah J Hardcastle
PURPOSE: To explore the barriers and experiences of accessing information for women who have received genetic risk assessment/testing results for breast cancer (BC) and are considering a bilateral prophylactic mastectomy (BPM) and, exploring participants' preferences concerning information and support needs. METHODS: A qualitative retrospective study guided by interpretative phenomenological analysis was utilised. Semi-structured interviews were conducted with forty-six women who were either considering BPM or had already undergone the surgery...
May 11, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29752327/adherence-to-guidelines-for-breast-surveillance-in-breast-cancer-survivors
#11
Kathryn J Ruddy, Lindsey Sangaralingham, Rachel A Freedman, Sarah Mougalian, Heather Neuman, Caprice Greenberg, Ahmedin Jemal, Narjust Duma, Tufia C Haddad, Valerie Lemaine, Karthik Ghosh, Tina J Hieken, Katie Hunt, Celine Vachon, Cary Gross, Nilay D Shah
Background: Guidelines recommend annual mammography after curative-intent treatment for breast cancer. The goal of this study was to assess contemporary patterns of breast imaging after breast cancer treatment. Methods: Administrative claims data were used to identify privately insured and Medicare Advantage beneficiaries with nonmetastatic breast cancer who had residual breast tissue (not bilateral mastectomy) after breast surgery between January 2005 and May 2015. We calculated the proportion of patients who had a mammogram, MRI, both, or neither during each of 5 subsequent 13-month periods...
May 2018: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29744328/bilateral-metachronous-breast-carcinoma-a-rare-case-report
#12
Anand Singla, Navneet Kaur, Darshanjeet Singh Walia, Deeksha Singla
The occurrence of bilateral breast cancer is rare. A second primary in the contralateral breast can either be synchronous or metachronous. Lobular carcinoma of the breast is known for its multicentricity and bilateral spread. The synchronous mixed pattern of carcinoma of the breast has also been reported in the same breast. The family history of breast carcinoma, estrogen receptor negativity, and human epidermal growth factor receptor-2 positivity are risk factors for the development of contralateral breast malignancy...
April 2018: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/29721054/international-consensus-on-the-clinical-management-of-inflammatory-breast-cancer-from-the-morgan-welch-inflammatory-breast-cancer-research-program-10th-anniversary-conference
#13
Naoto T Ueno, Jose Rodrigo Espinosa Fernandez, Massimo Cristofanilli, Beth Overmoyer, Dan Rea, Fedor Berdichevski, Mohamad El-Shinawi, Jennifer Bellon, Huong T Le-Petross, Anthony Lucci, Gildy Babiera, Sarah M DeSnyder, Mediget Teshome, Edward Chang, Bora Lim, Savitri Krishnamurthy, Michael C Stauder, Simrit Parmar, Mona M Mohamed, Angela Alexander, Vicente Valero, Wendy A Woodward
National and international experts in inflammatory breast cancer (IBC) from high-volume centers treating IBC recently convened at the 10th Anniversary Conference of the Morgan Welch Inflammatory Breast Cancer Research Program at The University of Texas MD Anderson Cancer Center in Houston Texas. A consensus on the clinical management of patients with IBC was discussed, summarized, and subsequently reviewed. All participants at the conference (patients, advocates, researchers, trainees, and clinicians) were queried using the MDRing electronic survey on key management issues...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29713993/influences-on-satisfaction-with-reconstructed-breasts-and-intimacy-in-younger-women-following-bilateral-prophylactic-mastectomy-a-qualitative-analysis
#14
Rachael Glassey, Moira O'Connor, Angela Ives, Christobel Saunders, Sarah J Hardcastle
PURPOSE: The aim of this study was to explore the influences on satisfaction with reconstructed breasts and intimacy following bilateral prophylactic mastectomy (BPM) in younger women (< 35) with a strong family history of breast cancer. METHODS: Twenty-six women who had undergone BPM between 1 and6 years ago were recruited from New Zealand and Australia through a genetics clinic, registry, research cohort, and online (Mage  = 31). Twenty-three were BRCA mutation carriers...
April 30, 2018: International Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/29710224/hormone-replacement-therapy-after-oophorectomy-and-breast-cancer-risk-among-brca1-mutation-carriers
#15
Joanne Kotsopoulos, Jacek Gronwald, Beth Y Karlan, Tomasz Huzarski, Nadine Tung, Pal Moller, Susan Armel, Henry T Lynch, Leigha Senter, Andrea Eisen, Christian F Singer, William D Foulkes, Michelle R Jacobson, Ping Sun, Jan Lubinski, Steven A Narod
Importance: Prophylactic bilateral salpingo-oophorectomy is recommended for BRCA1 mutation carriers to prevent ovarian cancer. Whether or not hormone replacement therapy (HRT) initiated after oophorectomy is associated with an increased risk of breast cancer has not been evaluated in a prospective study. Objective: To determine the association between HRT use and BRCA1-associated breast cancer. Design, Setting, and Participants: A prospective, longitudinal cohort study of BRCA1 and BRCA2 mutation carriers from 80 participating centers in 17 countries was conducted between 1995 and 2017 with a mean follow-up of 7...
April 19, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29704746/examining-upper-limb-kinematics-and-dysfunction-of-breast-cancer-survivors-in-functional-dynamic-tasks
#16
Rebecca L Brookham, Alan C Cudlip, Clark R Dickerson
BACKGROUND: Comorbidities within the breast cancer population can reduce quality of life. Current breast cancer survivor upper limb kinematic strategies unfortunately lack robust connection with performing important activities of daily living. METHODS: Accordingly, fifty breast cancer survivors performed 88 dynamic tasks (divided into range of motion-reach, range of motion-rotate, activity of daily living, and work tasks). Humerothoracic and scapulothoracic angles were extracted from motion capture data...
April 13, 2018: Clinical Biomechanics
https://www.readbyqxmd.com/read/29699894/durable-response-of-early-stage-breast-cancer-to-bilateral-definitive-sbrt-in-a-medically-inoperable-patient
#17
Robert W Gao, Sean S Park, James W Jakub, Tina J Hieken, Amy L Conners, Lonzetta Neal, Sandhya Pruthi, Kimberly S Corbin, Elizabeth S Yan, Robert W Mutter, Bradley J Stish
No abstract text is available yet for this article.
March 18, 2018: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29690864/radiogenic-angiosarcoma-of-the-breast-case-report-and-systematic-review-of-the-literature
#18
Askin Dogan, Peter Kern, Beate Schultheis, Günther Häusler, Günther A Rezniczek, Clemens B Tempfer
BACKGROUND: Radiogenic angiosarcoma of the breast (RASB) is a rare late sequela of local irradiation of the breast or chest wall after breast cancer. The prognosis of women with RASB is poor and there is no standardized therapy for this type of malignancy. CASE PRESENTATION: We present the case of a 54 year old woman with RASB (poorly differentiated angiosarcoma of the left breast; pT1, pNX, M0, L0, V0) and a history of invasive-ductal cancer of the left breast (pT1b, G2, pN0, ER positive, PR positive, HER-2/neu negative) treated in July 2012 with breast-conserving surgery, adjuvant chemotherapy with 6 cycles of epirubicin and cyclophosphamide, adjuvant irradiation of the left breast with 50 Gray, and adjuvant endocrine therapy with an aromatase inhibitor...
April 24, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29687179/bilateral-mastectomies-can-a-co-surgeon-technique-offer-improvements-over-the-single-surgeon-method
#19
Melissa Anne Mallory, Constantine Tarabanis, Eric Schneider, Suniti Nimbkar, Mehra Golshan
PURPOSE: Bilateral mastectomy (BM) is traditionally performed using a single-surgeon (SS) technique (SST); a co-surgeon (CS) technique (CST), where each attending surgeon concurrently performs a unilateral mastectomy, offers an alternative approach. We sought to compare the CST and SST for BM with respect to operative times and complications. METHODS: Patients undergoing BM without reconstruction at our institution between 2005 and 2015 were identified using operative caselogs and stratified into CS- and SS-cohorts...
April 23, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29681837/unusual-case-of-vogt-koyanagi-harada-disease-associated-with-sapho-syndrome-a-case-report
#20
Miyuki Hasegawa, Akira Fukutomi, Akiko Jinno, Kyoko Fujita, Motohiro Kamei
A 66-year-old Japanese woman who was diagnosed with synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome presented with bilateral blurred vision 4 months prior to visiting our hospital. She had visited a local ophthalmology clinic first. She was diagnosed with conjunctivitis and was prescribed antibacterial eye drops. The symptoms persisted in spite of treatment. She was then referred to our hospital. At her initial visit, the visual acuities were 0.6 in both eyes. A slit-lamp examination revealed bilateral shallow anterior chamber, and intraocular pressures of 18 mm Hg in the right eye and 16 mm Hg in the left eye...
January 2018: Case Reports in Ophthalmology
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