Nusrat Perween, Komal Pekhale, Gauri Haval, Gargi Sirkar, Ganesh S Bose, Smriti P K Mittal, Surendra Ghaskadbi, Saroj S Ghaskadbi
Intracellular antioxidant glutaredoxin controls cell proliferation and survival. Based on the active site, structure, and conserved domain motifs, it is classified into two classes. Class I contains dithiol Grxs with two cysteines in the consensus active site sequence CXXC, while class II has monothiol Grxs with one cysteine residue in the active site. Monothiol Grxs can also have an additional N-terminal thioredoxin (Trx)-like domain. Previously, we reported the characterization of Grx1 from Hydra vulgaris (HvGrx1), which is a dithiol isoform...
May 2, 2024: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology