Nathalia Araujo, James Sledziona, Sunil K Noothi, Ravshan Burikhanov, Nikhil Hebbar, Saptadwipa Ganguly, Tripti Shrestha-Bhattarai, Beibei Zhu, Wendy S Katz, Yi Zhang, Barry S Taylor, Jinze Liu, Li Chen, Heidi L Weiss, Daheng He, Chi Wang, Andrew J Morris, Lisa A Cassis, Mariana Nikolova-Karakashian, Prabhakar R Nagareddy, Olle Melander, B Mark Evers, Philip A Kern, Vivek M Rangnekar
Prostate apoptosis response-4 (Par-4) is a tumor suppressor that induces apoptosis in cancer cells. However, the physiological function of Par-4 remains unknown. Here we show that conventional Par-4 knockout (Par-4-/- ) mice and adipocyte-specific Par-4 knockout (AKO) mice, but not hepatocyte-specific Par-4 knockout mice, are obese with standard chow diet. Par-4-/- and AKO mice exhibit increased absorption and storage of fat in adipocytes. Mechanistically, Par-4 loss is associated with mdm2 downregulation and activation of p53...
2022: Frontiers in Oncology