Frederik Denorme, Nicole D Armstrong, Michelle L Stoller, Irina Portier, Emilia A Tugolukova, Rikki M Tanner, Emilie Montenont, Seema Bhatlekar, Mark Cody, John L Rustad, Abigail Ajanel, Neal D Tolley, Darian C Murray, Julie L Boyle, Marvin T Nieman, Steven E McKenzie, Christian Con Yost, Leslie A Lange, Mary Cushman, Marguerite R Irvin, Paul F Bray, Robert A Campbell
Protease activated receptor (PAR) 4 (gene: F2RL3) harbors a functional dimorphism, rs773902 A/G (encoding Thr120/Ala120, respectively) and is associated with greater platelet aggregation. The A allele frequency is more common in Black individuals, and Black individuals have a higher incidence of ischemic stroke than White individuals. However, it is not recognized whether the A allele is responsible for worse stroke outcomes. To directly test the in vivo effect of this variant on stroke, we generated mice where F2rl3 was replaced by F2RL3, thereby expressing human PAR4 (hPAR4) with either Thr120 or Ala120...
July 20, 2023: Journal of Clinical Investigation