keyword
Keywords drug-induced liver injury guid...

drug-induced liver injury guidelines

https://read.qxmd.com/read/36824034/-diagnosis-of-autoimmune-hepatitis
#21
REVIEW
Jeong Han Kim
Autoimmune hepatitis (AIH) is an immune-mediated inflammatory liver disease with an uncertain cause. The diagnosis of AIH is based on the characteristic clinical and laboratory findings (elevated liver enzyme and hypergammaglobulinemia), the presence of characteristic autoantibodies, and compatible histological abnormalities. AIH lacks a signature diagnostic marker, and the diagnosis requires the exclusion of other diseases (viral hepatitis, alcoholic liver disease, non-alcoholic steatohepatitis, drug-induced liver injury, Wilson's disease, and hereditary hemochromatosis)...
February 25, 2023: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://read.qxmd.com/read/36608050/mathematical-models-for-biomarker-calculation-of-drug-induced-liver-injury-in-humans-and-experimental-models-based-on-gadoxetate-enhanced-magnetic-resonance-imaging
#22
JOURNAL ARTICLE
Markus Karlsson, Christian Simonsson, Nils Dahlström, Gunnar Cedersund, Peter Lundberg
BACKGROUND: Drug induced liver injury (DILI) is a major concern when developing new drugs. A promising biomarker for DILI is the hepatic uptake rate of the contrast agent gadoxetate. This rate can be estimated using a novel approach combining magnetic resonance imaging and mathematical modeling. However, previous work has used different mathematical models to describe liver function in humans or rats, and no comparative study has assessed which model is most optimal to use, or focused on possible translatability between the two species...
2023: PloS One
https://read.qxmd.com/read/36597859/liver-tests-abnormalities-with-licensed-antiviral-drugs-for-covid-19-a-narrative-review
#23
JOURNAL ARTICLE
Giacomo Casalini, Andrea Giacomelli, Spinello Antinori
INTRODUCTION: Liver involvement in COVID-19 is multifactorial, and the three potential mechanisms are direct hepatocyte viral damage, vascular or cellular damage during the cytokine storm of severe COVID-19 and drug-induced liver injury. To date, three antivirals are licensed for the treatment of COVID-19 by most guidelines: remdesivir, molnupiravir, and ritonavir-boosted nirmatrelvir. AREAS COVERED: We performed a narrative review about the hepatic safety profile of the three antivirals licensed for COVID-19 treatment...
December 2022: Expert Opinion on Drug Safety
https://read.qxmd.com/read/36561659/deepcausality-a-general-ai-powered-causal-inference-framework-for-free-text-a-case-study-of-livertox
#24
JOURNAL ARTICLE
Xingqiao Wang, Xiaowei Xu, Weida Tong, Qi Liu, Zhichao Liu
Causality plays an essential role in multiple scientific disciplines, including the social, behavioral, and biological sciences and portions of statistics and artificial intelligence. Manual-based causality assessment from a large number of free text-based documents is very time-consuming, labor-intensive, and sometimes even impractical. Herein, we proposed a general causal inference framework named DeepCausality to empirically estimate the causal factors for suspected endpoints embedded in the free text. The proposed DeepCausality seamlessly incorporates AI-powered language models, named entity recognition and Judea Pearl's Do-calculus, into a general framework for causal inference to fulfill different domain-specific applications...
2022: Frontiers in artificial intelligence
https://read.qxmd.com/read/36473994/performance-assessment-and-economic-analysis-of-a-human-liver-chip-for-predictive-toxicology
#25
JOURNAL ARTICLE
Lorna Ewart, Athanasia Apostolou, Skyler A Briggs, Christopher V Carman, Jake T Chaff, Anthony R Heng, Sushma Jadalannagari, Jeshina Janardhanan, Kyung-Jin Jang, Sannidhi R Joshipura, Mahika M Kadam, Marianne Kanellias, Ville J Kujala, Gauri Kulkarni, Christopher Y Le, Carolina Lucchesi, Dimitris V Manatakis, Kairav K Maniar, Meaghan E Quinn, Joseph S Ravan, Ann Catherine Rizos, John F K Sauld, Josiah D Sliz, William Tien-Street, Dennis Ramos Trinidad, James Velez, Max Wendell, Onyi Irrechukwu, Prathap Kumar Mahalingaiah, Donald E Ingber, Jack W Scannell, Daniel Levner
BACKGROUND: Conventional preclinical models often miss drug toxicities, meaning the harm these drugs pose to humans is only realized in clinical trials or when they make it to market. This has caused the pharmaceutical industry to waste considerable time and resources developing drugs destined to fail. Organ-on-a-Chip technology has the potential improve success in drug development pipelines, as it can recapitulate organ-level pathophysiology and clinical responses; however, systematic and quantitative evaluations of Organ-Chips' predictive value have not yet been reported...
December 6, 2022: Commun Med (Lond)
https://read.qxmd.com/read/36401515/new-insights-into-herb-induced-liver-injury
#26
JOURNAL ARTICLE
Zhi-Tao Ma, Zhuo Shi, Xiao-He Xiao, Jiabo Wang
SIGNIFICANCE: Herbs are widely used worldwide. However, inappropriate use of some of the herbs can lead to herb-induced liver injury (HILI). Intriguingly, HILI incidents are on the rise and our understanding of the underlying etiologies is in progress, and hence an update on the current status of incidents as well as our understanding on the etiologies of HILI is appropriate. RECENT ADVANCES: HILI reports due to the use of some herbs that are traditionally considered to be safe are also on the rise...
November 18, 2022: Antioxidants & Redox Signaling
https://read.qxmd.com/read/36353223/case-report-development-of-vanishing-bile-duct-syndrome-in-stevens-johnson-syndrome-complicated-by-hemophagocytic-lymphohistiocytosis
#27
Wan-Chen Lin, Tyng-Shiuan Hsieh, Chia-Yu Chu
Background: Vanishing bile duct syndrome is a rare drug-induced disease characterized by cholestasis and ensuing ductopenia. Dermatological manifestations of drug hypersensitivity such as Stevens-Johnson syndrome and toxic epidermal necrolysis may also present in such cases. Hemophagocytic lymphohistiocytosis is a hyperimmune response caused by unchecked stimulation of macrophages, natural killer cells, and cytotoxic T lymphocytes. Case presentation: We report a severe case who presented with concurrent Stevens-Johnson syndrome and vanishing bile duct syndrome complicated by hemophagocytic lymphohistiocytosis after the ingestion of non-steroidal anti-inflammatory drugs...
2022: Frontiers in Medicine
https://read.qxmd.com/read/36296321/evaluation-of-drug-induced-liver-injury-in-hospitalized-patients-with-sars-cov-2-infection
#28
JOURNAL ARTICLE
Nicoleta Mihai, Catalin Tiliscan, Constanta Angelica Visan, Laurentiu Stratan, Oana Ganea, Stefan Sorin Arama, Mihai Lazar, Victoria Arama
Elevated liver enzymes are frequently reported in SARS-CoV-2-infected patients. Several mechanisms of liver injury have been proposed, but no clear conclusions were drawn. We aimed to evaluate hepatocellular and cholestatic injury in relation to the administration of potentially hepatotoxic drugs included in the current COVID-19 therapeutic guidelines in a retrospective cohort of 396 hospitalized COVID-19 patients. The main findings of our study are: (1) Significant increase in aminotransferases level was observed during hospitalization, suggesting drug-related hepatotoxicity...
October 17, 2022: Microorganisms
https://read.qxmd.com/read/35863836/low-dose-trimethoprim-sulfamethoxazole-for-the-treatment-of-pneumocystis-jirovecii-pneumonia-low-tmp-protocol-for-a-phase-iii-randomised-placebo-controlled-dose-comparison-trial
#29
JOURNAL ARTICLE
Zahra N Sohani, Guillaume Butler-Laporte, Andrew Aw, Sara Belga, Andrea Benedetti, Alex Carignan, Matthew P Cheng, Bryan Coburn, Cecilia T Costiniuk, Nicole Ezer, Dan Gregson, Andrew Johnson, Kosar Khwaja, Alexander Lawandi, Victor Leung, Sylvain Lother, Derek MacFadden, Michaeline McGuinty, Leighanne Parkes, Salman Qureshi, Valerie Roy, Barret Rush, Ilan Schwartz, Miranda So, Ranjani Somayaji, Darrell Tan, Emilie Trinh, Todd C Lee, Emily G McDonald
INTRODUCTION: Pneumocystis jirovecii pneumonia (PJP) is an opportunistic infection of immunocompromised hosts with significant morbidity and mortality. The current standard of care, trimethoprim-sulfamethoxazole (TMP-SMX) at a dose of 15-20 mg/kg/day, is associated with serious adverse drug events (ADE) in 20%-60% of patients. ADEs include hypersensitivity reactions, drug-induced liver injury, cytopenias and renal failure, all of which can be treatment limiting. In a recent meta-analysis of observational studies, reduced dose TMP-SMX for the treatment of PJP was associated with fewer ADEs, without increased mortality...
July 21, 2022: BMJ Open
https://read.qxmd.com/read/35848749/clinical-significance-of-transient-asymptomatic-elevations-in-aminotransferase-taeat-in-oncology
#30
REVIEW
James H Lewis, Sophia K Khaldoyanidi, Carolyn D Britten, Andrew H Wei, Marion Subklewe
Monitoring for liver injury remains an important aspect of drug safety assessment, including for oncotherapeutics. When present, drug-induced liver injury may limit the use or result in the discontinuation of these agents. Drug-induced liver injury can exhibit with a wide spectrum of clinical and biochemical manifestations, ranging from transient asymptomatic elevations in aminotransferases (TAEAT) to acute liver failure. Numerous oncotherapeutics have been associated with TAEAT, with published reports indicating a phenomenon in which patients may be asymptomatic without overt liver injury despite the presence of grade ≥3 aminotransferase elevations...
August 1, 2022: American Journal of Clinical Oncology
https://read.qxmd.com/read/35836762/hepatotoxicity-induced-by-biological-agents-clinical-features-and-current-controversies
#31
REVIEW
Nelia Hernandez, Fernando Bessone
Novel biological agents including cytokines and recombinant fusion proteins are increasingly prescribed for cancer, rheumatologic, autoimmune, and inflammatory diseases, and are currently being evaluated in hepatocellular carcinoma (HCC). They are classified by their mechanism of action and include tumor necrosis factor-alpha (TNF-α) antagonists, T cell mediated antitumor inhibitors, interleukin receptor antagonists, and immune checkpoint inhibitors (ICIs). Some ICIs cause frequent hepatotoxicity with a variable clinical, biochemical, and serological presentation, especially in patients receiving another immunomodulatory agent...
June 28, 2022: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/35831683/kidney-damage-and-stress-biomarkers-for-early-identification-of-drug-induced-kidney-injury-a-systematic-review
#32
Ravi J Desai, Christina L Kazarov, Adrian Wong, Sandra L Kane-Gill
INTRODUCTION: Acute kidney injury (AKI) resulting from nephrotoxic medication use is prominent in hospitalized patients and is attributable to overall increases in mortality and costs of care. Serum creatinine (SCr), the current standard for identifying drug-induced AKI (DIAKI) is often delayed in its response to kidney insult by 26-36 h. OBJECTIVE: This systematic review seeks to evaluate the clinical utility of several novel kidney damage and stress biomarkers for the prediction/timely detection of DIAKI, in comparison with traditional methods...
August 2022: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://read.qxmd.com/read/35722609/guideline-review-easl-clinical-practice-guidelines-drug-induced-liver-injury-dili
#33
JOURNAL ARTICLE
Paul N Brennan, Peter Cartlidge, Thomas Manship, John F Dillon
The European Association for the Study of the Liver has produced extensive guidelines for the investigation and management of drug-induced liver injury. Here, we provide a commentary and overview of some of the principle disease investigations and management that arise from these guideline recommendations.
2022: Frontline Gastroenterology
https://read.qxmd.com/read/35665891/protective-effects-of-fowl-origin-cadmium-tolerant-lactobacillus-against-sub-chronic-cadmium-induced-toxicity-in-chickens
#34
JOURNAL ARTICLE
Da-Wei Chen, Hui-Jia Li, YinYin Liu, Li-Na Ma, Jun-Hua Pu, JunXian Lu, Xiu-Jun Tang, Yu-Shi Gao
Cadmium (Cd) directly endangers poultry health and indirectly causes harm to human health by food chain. Numerous studies have focused on removing Cd using lactic acid bacteria (LAB). However, there is still a lack of in vivo studies to validate whether Cd can be absorbed successfully by LAB to alleviate Cd toxicity. Here, we aimed to isolated and screened poultry-derived Cd-tolerant LAB with the strongest adsorption capacity in vitro and investigate the protective effect of which on sub-chronic Cd toxicity in chickens...
October 2022: Environmental Science and Pollution Research International
https://read.qxmd.com/read/35635048/role-of-silymarin-as-antioxidant-in-clinical-management-of-chronic-liver-diseases-a-narrative-review
#35
REVIEW
Alessio Aghemo, Olga P Alekseeva, Francesco Angelico, Igor G Bakulin, Natalia V Bakulina, Dmitry Bordin, Alexey O Bueverov, Oxana M Drapkina, Anton Gillessen, Elvira M Kagarmanova, Natalia V Korochanskaya, U A Kucheryavii, Leonid B Lazebnik, Maria A Livzan, Igor V Maev, Anatolii I Martynov, Marina F Osipenko, Evgenii I Sas, Antonina Starodubova, Yurii P Uspensky, Elena V Vinnitskaya, Emilia P Yakovenko, Alexey A Yakovlev
Chronic liver disease (CLD), manifested as hepatic injury, is a major cause of global morbidity and mortality. CLD progresses to fibrosis, cirrhosis, and-ultimately-hepatocellular carcinoma (HCC) if left untreated. The different phenotypes of CLD based on their respective clinical features and causative agents include alcoholic liver disease (ALD), non-alcoholic fatty liver disease (NAFLD), metabolic-associated fatty liver disease (MAFLD), and drug-induced liver injury (DILI). The preferred treatment modality for CLD includes lifestyle modification and diet, along with limited pharmacological agents for symptomatic treatment...
December 2022: Annals of Medicine
https://read.qxmd.com/read/35434055/escitalopram-induced-hepatitis-a-case-report
#36
Guillaume Wabont, Laurie Ferret, Nicolas Houdre, Antoine Lepied, Johana Bene, Etienne Cousein
BACKGROUND: The antidepressant escitalopram is widely prescribed for the treatment of depression. It is generally well-tolerated, and cholestasis is not mentioned in its summary of product characteristics (SmPC). We present a case of cholestatic and cytolysis liver injury due to escitalopram and a VigiBase® study. CASE SUMMARY: A 68-year-old man was admitted to our emergency unit due to clinical jaundice associated with hepatitis, pruritus and dark urine. We tested the patient for the most common etiologies of jaundice, including hemolysis, viral hepatitis, cirrhosis, carcinoma, cholangitis, cholelithiasis and intrahepatic or extrahepatic obstruction...
March 16, 2022: World Journal of Clinical Cases
https://read.qxmd.com/read/35093672/comparative-effectiveness-of-glycyrrhizic-acid-preparations-aimed-at-preventing-and-treating-anti-tuberculosis-drug-induced-liver-injury-a-network-meta-analysis-of-97-randomized-controlled-trials
#37
JOURNAL ARTICLE
Jin-Yu Gong, Huan Ren, Si-Yin Peng, Kai Xing, Li Fan, Mou-Ze Liu, Zhi-Ying Luo, Jian-Quan Luo
BACKGROUND AND OBJECTIVES: Clinical guidelines and expert consensus do not yet recommend glycyrrhizic acid (GA) preparations, such as compound glycyrrhizin, diammonium glycyrrhizin, magnesium isoglycyrrhizinate (MGIG), et al., for the prevention of anti-tuberculosis(anti-TB) drug-induced liver injury (DILI) due to insufficient evidence. Although these GA preparations are recommended for the treatment of anti-TB DILI, which one performs best is unclear. Previous conventional meta-analyses did not summarize the results of simultaneous comparisons of different glycyrrhizinate preparations...
January 15, 2022: Phytomedicine
https://read.qxmd.com/read/34868896/current-status-of-glucocorticoid-usage-in-solid-organ-transplantation
#38
REVIEW
Simin Dashti-Khavidaki, Reza Saidi, Hong Lu
Glucocorticoids (GCs) have been the mainstay of immunosuppressive therapy in solid organ transplantation (SOT) for decades, due to their potent effects on innate immunity and tissue protective effects. However, some SOT centers are reluctant to administer GCs long-term because of the various related side effects. This review summarizes the advantages and disadvantages of GCs in SOT. PubMed and Scopus databases were searched from 2011 to April 2021 using search syntaxes covering "transplantation" and "glucocorticoids"...
November 18, 2021: World Journal of Transplantation
https://read.qxmd.com/read/34790517/bile-acid-nephropathy-induced-by-anabolic-steroids-a-case-report-and-review-of-the-literature
#39
JOURNAL ARTICLE
Hamdan Al Awadhi, Sarah Al Qassimi, Aya Akhras, Leal Herlitz, Muriel Ghosn
Bile acid nephropathy also known as cholemic nephropathy is a rare and overlooked form of acute kidney injury that occurs in the setting of severe hyperbilirubinemia. The exact etiology remains unknown, and there is a lack of treatment guidelines for this clinical condition. Anabolic steroids are known to cause hepatoxicity occasionally leading to acute kidney injury. We report the case of a 27-year-old male patient who developed bile acid nephropathy as a result of severe hyperbilirubinemia secondary to anabolic steroids-induced liver injury...
2021: Clinical Nephrology. Case Studies
https://read.qxmd.com/read/34776963/role-of-ursodeoxycholic-acid-in-treating-and-preventing-idiosyncratic-drug-induced-liver-injury-a-systematic-review
#40
REVIEW
Mercedes Robles-Díaz, Lana Nezic, Vesna Vujic-Aleksic, Einar S Björnsson
Introduction: Treatment is generally not available for drug-induced liver injury (DILI) patients except in some specific circumstances. The management of DILI is based on the withdrawal of the responsible drug and monitoring the patients and only a few patients need to be referred to a transplant center. Some studies on the role of ursodeoxycholic acid (UDCA) in DILI have been published. The aim of this study was to perform a systematic review of the role of UDCA in the treatment and prevention of DILI. Methods: A search was undertaken in PubMed, with the key words ursodeoxycholic acid, drug-induced liver injury and hepatotoxicity following the PRISMA guidelines...
2021: Frontiers in Pharmacology
keyword
keyword
86052
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.