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drug-induced liver injury guidelines

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https://www.readbyqxmd.com/read/28615012/moxifloxacin-monotherapy-versus-combination-therapy-in-patients-with-severe-community-acquired-pneumonia-evoked-ards
#1
Tim Rahmel, Sven Asmussen, Jan Karlik, Jörg Steinmann, Michael Adamzik, Jürgen Peters
BACKGROUND: We tested the hypothesis that moxifloxacin monotherapy is equally effective and safe as a betalactam antibiotic based combination therapy in patients with acute respiratory distress syndrome (ARDS) evoked by severe community acquired pneumonia (CAP). METHODS: In a retrospective chart review study of 229 patients with adult respiratory distress syndrome (ARDS) admitted to our intensive care unit between 2001 and 2011, 169 well-characterized patients were identified to suffer from severe CAP...
June 14, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/28539989/hepatic-complications-induced-by-immunosuppressants-and-biologics-in-inflammatory-bowel-disease
#2
REVIEW
My-Linh Tran-Minh, Paula Sousa, Marianne Maillet, Matthieu Allez, Jean-Marc Gornet
The incidence of inflammatory bowel diseases (IBD) is rising worldwide. The therapeutic options for IBD are expanding, and the number of drugs with new targets will rapidly increase in coming years. A rapid step-up approach with close monitoring of intestinal inflammation is extensively used. The fear of side effects represents one the most limiting factor of their use. Despite a widespread use for years, drug induced liver injury (DILI) management remains a challenging situation with Azathioprine and Methotrexate...
May 8, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28471945/metabolic-concerns-in-aging-hiv-infected-persons-from-serum-lipid-phenotype-to-fatty-liver
#3
Giovanni Guaraldi, Amedeo Lonardo, Liliana Maia, Frank J Palella
: Among HIV-infected persons, the assessment of nonalcoholic fatty liver disease (NAFLD) provides a window through which overall metabolic health can be evaluated. In this review, we summarize clinical data that support the roles of aging and metabolic dysregulation as factors contributing to fatty liver/NAFLD among HIV-infected persons.Age-related metabolic alterations include hepatic anatomic and functional changes, altered homeostasis of gastrointestinal microbiota and anthropometric changes (such as a shift of body fat depots from the subcutaneous to the visceral compartment) that are often associated with the development of insulin resistance and increased cardiovascular risk...
June 1, 2017: AIDS
https://www.readbyqxmd.com/read/28443154/drug-induced-liver-injury-do-we-know-everything
#4
REVIEW
Tamara Alempijevic, Simon Zec, Tomica Milosavljevic
Interest in drug-induced liver injury (DILI) has dramatically increased over the past decade, and it has become a hot topic for clinicians, academics, pharmaceutical companies and regulatory bodies. By investigating the current state of the art, the latest scientific findings, controversies, and guidelines, this review will attempt to answer the question: Do we know everything? Since the first descriptions of hepatotoxicity over 70 years ago, more than 1000 drugs have been identified to date, however, much of our knowledge of diagnostic and pathophysiologic principles remains unchanged...
April 8, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28405790/csh-guidelines-for-the-diagnosis-and-treatment-of-drug-induced-liver-injury
#5
EDITORIAL
Yue-Cheng Yu, Yi-Min Mao, Cheng-Wei Chen, Jin-Jun Chen, Jun Chen, Wen-Ming Cong, Yang Ding, Zhong-Ping Duan, Qing-Chun Fu, Xiao-Yan Guo, Peng Hu, Xi-Qi Hu, Ji-Dong Jia, Rong-Tao Lai, Dong-Liang Li, Ying-Xia Liu, Lun-Gen Lu, Shi-Wu Ma, Xiong Ma, Yue-Min Nan, Hong Ren, Tao Shen, Hao Wang, Ji-Yao Wang, Tai-Ling Wang, Xiao-Jin Wang, Lai Wei, Qing Xie, Wen Xie, Chang-Qing Yang, Dong-Liang Yang, Yan-Yan Yu, Min-de Zeng, Li Zhang, Xin-Yan Zhao, Hui Zhuang
Drug-induced liver injury (DILI) is an important clinical problem, which has received more attention in recent decades. It can be induced by small chemical molecules, biological agents, traditional Chinese medicines (TCM), natural medicines (NM), health products (HP), and dietary supplements (DS). Idiosyncratic DILI is far more common than intrinsic DILI clinically and can be classified into hepatocellular injury, cholestatic injury, hepatocellular-cholestatic mixed injury, and vascular injury based on the types of injured target cells...
May 2017: Hepatology International
https://www.readbyqxmd.com/read/28166913/novel-risk-factors-and-early-detection-of-anti-tubercular-treatment-induced-liver-injury-looking-beyond-american-thoracic-society-guidelines
#6
Muzamil Latief, Waseem Raja Dar, Najeebullah Sofi, Imtiyaz Ahmad Dar, Basharat Kasana, Moomin Hussain, Faheem Arshad, Bashir Ahmad Shah, Parvaiz Ahmad Koul
INTRODUCTION: ATT remains the standard treatment for tuberculosis. Drug-induced liver injury (DILI) has been a long-standing concern in the treatment of tuberculosis (TB) infection. AIMS AND OBJECTIVES: To study the occurrence and risk factors of DILI in patients on ATT by regular clinical and biochemical monitoring. MATERIALS AND METHODS: 200 patients, in whom ATT was started, were enrolled in the study. None of the patients with established risk factor for DILI as recognized by ATS guidelines was included in our study population...
January 2017: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/27832041/investigation-of-liver-dysfunction-who-should-we-test-for-hepatitis-e
#7
Sebastian J Wallace, Glynn W Webb, Richie G Madden, Hugh C Dalton, Joanne Palmer, Richard T Dalton, Adam Pollard, Rhys Martin, Vasilis Panayi, Gwyn Bennett, Richard P Bendall, Harry R Dalton
AIM: Hepatitis E virus (HEV) is endemic in developed countries, but unrecognized infection is common. Many national guidelines now recommend HEV testing in patients with acute hepatitis irrespective of travel history. The biochemical definition of 'hepatitis' that best predicts HEV infection has not been established. This study aimed to determine parameters of liver biochemistry that should prompt testing for acute HEV. METHODS: This was a retrospective study of serial liver function tests (LFTs) in cases of acute HEV (n=74) and three comparator groups: common bile duct stones (CBD, n=87), drug-induced liver injury (DILI, n=69) and patients testing negative for HEV (n=530)...
February 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27721739/the-diagnosis-and-manifestations-of-liver-injury-secondary-to-off-label-androgenic-anabolic-steroid-use
#8
Elena Cabb, Shanna Baltar, David Wes Powers, Karthik Mohan, Antonio Martinez, Eric Pitts
Drug-induced liver injury (DILI) presents as a broad spectrum of adverse drug reactions which can range from a mild elevation in liver enzymes to fulminant liver failure. The primary goal is to identify DILI early when the patient's liver enzymes are elevated and to discontinue the offending agent as soon as possible to prevent further injury. Herbal, dietary supplements and anabolic steroids represent a significant component of the drugs thought to cause DILI in the United States. Unlike all other drugs known to cause DILI, these drugs fall into a category of injury that is neither intrinsic nor idiosyncratic due to overlapping characteristics between the two...
May 2016: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/27550489/the-prescription-pattern-of-acetaminophen-and-non-steroidal-anti-inflammatory-drugs-in-patients-with-liver-cirrhosis
#9
Young Mi Hong, Ki Tae Yoon, Jeong Heo, Hyun Young Woo, Won Lim, Dae Seong An, Jun Hee Han, Mong Cho
Analgesics, known to be hepatotoxic drugs, are frequently prescribed to patients with liver cirrhosis who are prone to drug-induced liver injury. No guidelines are available regarding the prescription of analgesics in these patients. Therefore, we aimed to evaluate the prescription pattern of most frequently used analgesics in patients with cirrhosis. We assessed the prescription pattern of acetaminophen and non-steroidal anti-inflammatory drugs (NSAIDs) in patients with liver cirrhosis registered in Health Insurance Review Assessment Service database between January 1, 2012 and December 31, 2012...
October 2016: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27468221/bile-cast-nephropathy-a-case-report-and-review-of-the-literature
#10
REVIEW
Jaymon Patel, Saqib Walayat, Nikhil Kalva, Sidney Palmer-Hill, Sonu Dhillon
Bile cast nephropathy is a condition of renal dysfunction in the setting of hyperbilirubinemia. There are very few cases of this condition reported in the last decade and a lack of established treatment guidelines. While the exact etiology remains unknown, bile cast nephropathy is presumed to be secondary to multiple concurrent insults to the kidney including direct toxicity from bile acids, obstructive physiology from bile casts, and systemic hypoperfusion from vasodilation. Therapy directed at bilirubin reduction may improve renal function, but will likely need dialysis or plasmapheresis as well...
July 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27311472/adverse-outcome-pathways-as-tools-to-assess-drug-induced-toxicity
#11
Mathieu Vinken
Adverse outcome pathways (AOPs) are novel tools in toxicology and human risk assessment with broad potential. AOPs are designed to provide a clear-cut mechanistic representation of toxicological effects that span over different layers of biological organization. AOPs share a common structure consisting of a molecular initiating event, a series of key events connected by key event relationships, and an adverse outcome. Development and evaluation of AOPs ideally complies with guidelines issued by the Organization for Economic Cooperation and Development...
2016: Methods in Molecular Biology
https://www.readbyqxmd.com/read/26370854/currently-used-low-dose-pyrazinamide-does-not-increase-liver-injury-in-the-first-two-months-of-tuberculosis-treatment
#12
Nobuyuki Horita, Naoki Miyazawa, Takashi Yoshiyama, Ryota Kojima, Yoshiaki Ishigatsubo, Takeshi Kaneko
OBJECTIVE: In the 1950s, a high-dose (40-70 mg/kg/day) of pyrazinamide (PZA), was reported to cause drug-induced liver injury (DILI) at an unacceptable frequency. It remains unclear whether adding PZA (Z) at the currently accepted low-dose (20-25 mg/kg/day) for two months to a regimen of isoniazid (H) + rifampicin (R) + ethambutol (E) actually increases the risk of DILI. METHOD: Smear-positive tuberculosis patients were treated with daily HRE or HRZE regimen under direct observation...
2015: Internal Medicine
https://www.readbyqxmd.com/read/26288292/-clinical-guidelines-rational-use-of-nonsteroidal-anti-inflammatory-drugs-nsaids-in-clinical-practice-part-i
#13
(no author information available yet)
No abstract text is available yet for this article.
2015: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/26243373/preventive-use-of-a-hepatoprotectant-against-anti-tuberculosis-drug-induced-liver-injury-a-randomized-controlled-trial
#14
RANDOMIZED CONTROLLED TRIAL
Simin Zhang, Hongqiu Pan, Xianzhen Peng, Hui Lu, Hong Fan, Xianzhi Zheng, Guisheng Xu, Min Wang, Jianming Wang
BACKGROUND AND AIM: Hepatoprotectants are routinely prescribed in China to prevent anti-tuberculosis drug-induced liver injury (ATLI). However, their biological mechanisms have not yet been clearly demonstrated. This study aims to evaluate the preventive effects of Silybum marianum against drug-induced liver injury among tuberculosis patients and to provide clinical guidelines for tuberculosis management in China. METHODS: A randomized controlled trial was performed in Jiangsu, China...
February 2016: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/26116527/the-art-and-science-of-diagnosing-and-managing-drug-induced-liver-injury-in-2015-and-beyond
#15
REVIEW
James H Lewis
Drug-induced liver injury (DILI) remains a leading reason why new compounds are dropped from further study or are the subject of product warnings and regulatory actions. Hy's Law of drug-induced hepatocellular jaundice causing a case-fatality rate or need for transplant of 10% or higher has been validated in several large national registries, including the ongoing, prospective U.S. Drug-Induced Liver Injury Network. It serves as the basis for stopping rules in clinical trials and in clinical practice. Because DILI can mimic all known causes of acute and chronic liver disease, establishing causality can be difficult...
November 2015: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/25899987/characterisation-of-liver-chemistry-abnormalities-associated-with-pazopanib-monotherapy-a-systematic-review-and-meta-analysis-of-clinical-trials-in-advanced-cancer-patients
#16
REVIEW
Thomas Powles, Sergio Bracarda, Mei Chen, Elliot Norry, Natalie Compton, Mark Heise, Thomas Hutson, Philipp Harter, Christopher Carpenter, Lini Pandite, Neil Kaplowitz
Drug-induced liver chemistry abnormalities, primarily transaminase elevations, are commonly observed in pazopanib-treated patients. This meta-analysis characterises liver chemistry abnormalities associated with pazopanib. Data of pazopanib-treated patients from nine prospective trials were integrated (N=2080). Laboratory datasets were used to characterise the incidence, timing, recovery and patterns of liver events, and subsequent rechallenge with pazopanib. Severe cases of liver chemistry abnormalities were clinically reviewed...
July 2015: European Journal of Cancer
https://www.readbyqxmd.com/read/25831728/-reduction-and-withdrawal-of-chemotherapy
#17
Shigeo Yamaguchi, Shunsuke Kato
No abstract text is available yet for this article.
February 2015: Nihon Rinsho. Japanese Journal of Clinical Medicine
https://www.readbyqxmd.com/read/25733005/pevonedistat-mln4924-a-first-in-class-nedd8-activating-enzyme-inhibitor-in-patients-with-acute-myeloid-leukaemia-and-myelodysplastic-syndromes-a-phase-1-study
#18
MULTICENTER STUDY
Ronan T Swords, Harry P Erba, Daniel J DeAngelo, Dale L Bixby, Jessica K Altman, Michael Maris, Zhaowei Hua, Stephen J Blakemore, Hélène Faessel, Farhad Sedarati, Bruce J Dezube, Francis J Giles, Bruno C Medeiros
This trial was conducted to determine the dose-limiting toxicities (DLTs) and maximum tolerated dose (MTD) of the first in class NEDD8-activating enzyme (NAE) inhibitor, pevonedistat, and to investigate pevonedistat pharmacokinetics and pharmacodynamics in patients with acute myeloid leukaemia (AML) and myelodysplastic syndromes (MDS). Pevonedistat was administered via a 60-min intravenous infusion on days 1, 3 and 5 (schedule A, n = 27), or days 1, 4, 8 and 11 (schedule B, n = 26) every 21-days. Dose escalation proceeded using a standard '3 + 3' design...
May 2015: British Journal of Haematology
https://www.readbyqxmd.com/read/25724701/under-reporting-and-poor-adherence-to-monitoring-guidelines-for-severe-cases-of-isoniazid-hepatotoxicity
#19
Paul H Hayashi, Robert J Fontana, Naga P Chalasani, Andrew A Stolz, Jay A Talwalkar, Victor J Navarro, William M Lee, Timothy J Davern, David E Kleiner, Jiezhun Gu, Jay H Hoofnagle
BACKGROUND & AIMS: Isoniazid is a leading cause of liver injury but it is not clear how many cases are reported or how many clinicians and patients adhere to American Thoracic Society (ATS) guidelines. We collected data on cases of isoniazid hepatotoxicity and assessed adherence to ATS guidelines and reports to the Centers for Disease Control's (CDC) isoniazid severe adverse events program. METHODS: We analyzed Drug-Induced Liver Injury Network (DILIN) cases considered definite, highly likely, or probable for isoniazid injury from 2004 through 2013...
September 2015: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/25671485/paracetamol-overdose
#20
Natasha Palipane, Estabrak Jiad, Jacob F de Wolff
No abstract text is available yet for this article.
February 2015: British Journal of Hospital Medicine
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