keyword
MENU ▼
Read by QxMD icon Read
search

Regional interdependence

keyword
https://www.readbyqxmd.com/read/29326069/positive-correlation-between-rat-brain-glutamate-concentrations-and-mitochondrial-2-oxoglutarate-dehydrogenase-activity
#1
Garik V Mkrtchyan, Anastasia Graf, Lidia Trofimova, Alexander Ksenofontov, Ludmila Baratova, Victoria Bunik
Glutamate is a key metabolite and major excitatory neurotransmitter, degraded through transformation to 2-oxoglutarate which is further catabolized by 2-oxoglutarate dehydrogenase complex (OGDHC). Both the glutamate excitotoxicity and impaired OGDHC activity are hallmarks of neurodegeneration. This work quantifies a relationship between the brain OGDHC activity and glutamate levels, assessing its diagnostic value to characterize (patho)physiology. A moderate to strong positive correlation of the two parameters determined under varied physiological settings (brain regions, seasons, gender, pregnancy, rat line), is revealed...
January 8, 2018: Analytical Biochemistry
https://www.readbyqxmd.com/read/29298898/a-triad-of-residues-is-functionally-transferrable-between-5-ht3-serotonin-receptors-and-nicotinic-acetylcholine-receptors
#2
Richard Mosesso, Dennis A Dougherty
Cys-loop receptors are pentameric ligand-gated ion channels that facilitate communication within the nervous system. Upon neurotransmitter binding, these receptors undergo an allosteric activation mechanism connecting the binding event to the membrane-spanning channel pore, which expands to conduct ions. Some of the earliest steps in this activation mechanism are carried out by residues proximal to the binding site, the relative positioning of which may reflect functional differences among members of the Cys-loop family of receptors...
January 3, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29295926/preservation-of-the-genetic-diversity-of-a-local-common-carp-in-the-agricultural-heritage-rice-fish-system
#3
Weizheng Ren, Liangliang Hu, Liang Guo, Jian Zhang, Lu Tang, Entao Zhang, Jiaen Zhang, Shiming Luo, Jianjun Tang, Xin Chen
We examined how traditional farmers preserve the genetic diversity of a local common carp (Cyprinus carpio), which is locally referred to as "paddy field carp" (PF-carp), in a "globally important agricultural heritage system" (GIAHS), i.e., the 1,200-y-old rice-fish coculture system in Zhejiang Province, China. Our molecular and morphological analysis showed that the PF-carp has changed into a distinct local population with higher genetic diversity and diverse color types. Within this GIAHS region, PF-carps exist as a continuous metapopulation, although three genetic groups could be identified by microsatellite markers...
January 2, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29282048/exploring-factors-associated-with-the-uneven-utilization-of-telemedicine-in-norway-a-mixed-methods-study
#4
H Alami, M P Gagnon, R Wootton, J P Fortin, P Zanaboni
BACKGROUND: Norway has a long history of using telemedicine, especially for geographical reasons. Despite the availability of promising telemedicine applications and the implementation of national initiatives and policies, the sustainability and scaling-up of telemedicine in the health system is still far from accomplished. The main objective of this study was to explore and identify the multi-level (micro, meso and macro) factors affecting telemedicine utilization in Norway. METHODS: We used a mixed methods approach...
December 28, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/29213176/adapting-agricultural-water-use-to-climate-change-in-a-post-soviet-context-challenges-and-opportunities-in-southeast-kazakhstan
#5
Tristam Barrett, Giuseppe Feola, Marina Khusnitdinova, Viktoria Krylova
The convergence of climate change and post-Soviet socio-economic and institutional transformations has been underexplored so far, as have the consequences of such convergence on crop agriculture in Central Asia. This paper provides a place-based analysis of constraints and opportunities for adaptation to climate change, with a specific focus on water use, in two districts in southeast Kazakhstan. Data were collected by 2 multi-stakeholder participatory workshops, 21 semi-structured in-depth interviews, and secondary statistical data...
2017: Human Ecology: An Interdisciplinary Journal
https://www.readbyqxmd.com/read/29201492/agropastoral-mobility-and-rangelands-multiple-uses-in-the-miombo-frontier-ecozone-of-tabora-region-western-tanzania
#6
George Felix Masanja
This study aimed to examine the argument of environmental resource-use conflict as the primary cause of crop farmers and agropastoralists conflicts in Tabora Region, Tanzania. It explored the multiple interdependent phenomena that affect livelihoods relationships between crop farmers and agropastoralists and the nature of their continuing conflicts over the ecozonal resources. A primary dataset of the two groups' conflicts was used. An ex post facto and multistage sampling design was adopted. A total of 252 respondents were interviewed in three separate villages drawn from agroecological zones fringing the miombo woodland where such tensions are high...
2017: Scientifica
https://www.readbyqxmd.com/read/29171128/soil-ph-as-the-chief-modifier-for-regional-nitrous-oxide-emissions-new-evidence-and-implications-for-global-estimates-and-mitigation
#7
Yajing Wang, Jingheng Guo, Rolf David Vogt, Jan Mulder, Jingguo Wang, Xiaoshan Zhang
Nitrous oxide (N2 O) is a greenhouse gas that also plays the primary role in stratospheric ozone depletion. The use of nitrogen fertilizers is known as the major reason for atmospheric N2 O increase. Empirical bottom-up models therefore estimate agricultural N2 O inventories using N loading as the sole predictor, disregarding the regional heterogeneities in soil inherent response to external N loading. Several environmental factors have been found to influence the response in soil N2 O emission to N fertilization, but their interdependence and relative importance have not been addressed properly...
November 24, 2017: Global Change Biology
https://www.readbyqxmd.com/read/29169033/mapping-complex-mind-states-eeg-neural-substrates-of-meditative-unified-compassionate-awareness
#8
Poppy L A Schoenberg, Andrea Ruf, John Churchill, Daniel P Brown, Judson A Brewer
Specific mental training cultivates diminished self-reference, encompassing non-duality, emptiness, awakened-awareness, and compassionate experiences. We aimed to elucidate the neural substrates of four distinct, interdependent Essence-of-Mind states: (1) timelessness, (2) non-preference, non-duality, non-conceptualization, (3) the view of luminosity and limitlessness, (4) unified compassionate experience of oneness (stable awakened-awareness). EEG data were collected from 30 advanced meditators concomitant to eyes-open/eyes-closed resting baseline, followed by 60-min of instructed practice...
November 20, 2017: Consciousness and Cognition
https://www.readbyqxmd.com/read/29148575/effects-of-spot-parameters-in-pencil-beam-scanning-treatment-planning
#9
Aafke Christine Kraan, Nicolas Depauw, Ben Clasie, Marina Giunta, Tom Madden, Hanne M Kooy
BACKGROUND: Spot size σ (in-air at isocenter), inter-spot spacing d, and spot charge q influence dose delivery efficiency and plan quality in Intensity Modulated Proton Therapy (IMPT) treatment planning. The choice and range of parameters varies among different manufacturers. The goal of this work is to demonstrate the influence of the spot parameters on dose quality and delivery in IMPT treatment plans, to show their interdependence, and to make practitioners aware of the spot parameter values for a certain facility...
November 17, 2017: Medical Physics
https://www.readbyqxmd.com/read/29138620/cutaneous-microflora-from-geographically-isolated-groups-of-bradysia-agrestis-an-insect-vector-of-diverse-plant-pathogens
#10
Jong Myong Park, Young-Hyun You, Jong-Han Park, Hyeong-Hwan Kim, Sa-Youl Ghim, Chang-Gi Back
Larvae of Bradysia agrestis, an insect vector that transports plant pathogens, were sampled from geographically isolated regions in Korea to identify their cutaneous fungal and bacterial flora. Sampled areas were chosen within the distribution range of B. agrestis; each site was more than 91 km apart to ensure geographical segregation. We isolated 76 microbial (fungi and bacteria) strains (site 1, 29; site 2, 29; site 3, 18 strains) that were identified on the basis of morphological differences. Species identification was molecularly confirmed by determination of universal fungal internal transcribed spacer and bacterial 16S rRNA gene sequences in comparison to sequences in the EzTaxon database and the NCBI GenBank database, and their phylogenetic relationships were determined...
September 2017: Mycobiology
https://www.readbyqxmd.com/read/29134248/the-ancient-claudin-dni2-facilitates-yeast-cell-fusion-by-compartmentalizing-dni1-into-a-membrane-subdomain
#11
M-Ángeles Curto, Sandra Moro, Francisco Yanguas, Carmen Gutiérrez-González, M-Henar Valdivieso
Dni1 and Dni2 facilitate cell fusion during mating. Here, we show that these proteins are interdependent for their localization in a plasma membrane subdomain, which we have termed the mating fusion domain. Dni1 compartmentation in the domain is required for cell fusion. The contribution of actin, sterol-dependent membrane organization, and Dni2 to this compartmentation was analysed, and the results showed that Dni2 plays the most relevant role in the process. In turn, the Dni2 exit from the endoplasmic reticulum depends on Dni1...
November 13, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/29125409/interdependence-in-decision-making-by-medical-consultants-implications-for-improving-the-efficiency-of-inpatient-physician-services
#12
Adam S Wilk, Lena M Chen
OBJECTIVES: Hospital administrators are seeking to improve efficiency in medical consultation services, yet whether consultants make decisions to provide more or less care is unknown. We examined how medical consultants account for prior consultants' care when determining whether to provide intensive consulting care or sign off in the treatment of complex surgical inpatients. We applied three distinct theoretical frameworks in the interpretation of our results. METHODS: We performed a retrospective cohort study of consultants' care intensity, measured alternately using a dummy variable for providing two or more days consulting (versus one) and a continuous measure of total days consulting, with 100% Medicare claims data from 2007-2010...
November 10, 2017: Hospital Practice (Minneapolis)
https://www.readbyqxmd.com/read/29121600/use-of-surrogate-indicators-for-the-evaluation-of-potential-health-risks-due-to-poor-urban-water-quality-a-bayesian-network-approach
#13
Buddhi Wijesiri, Kaveh Deilami, James McGree, Ashantha Goonetilleke
Urban water pollution poses risks of waterborne infectious diseases. Therefore, in order to improve urban liveability, effective pollution mitigation strategies are required underpinned by predictions generated using water quality models. However, the lack of reliability in current modelling practices detrimentally impacts planning and management decision making. This research study adopted a novel approach in the form of Bayesian Networks to model urban water quality to better investigate the factors that influence risks to human health...
November 6, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29118111/differential-cell-matrix-mechanoadaptations-and-inflammation-drive-regional-propensities-to-aortic-fibrosis-aneurysm-or-dissection-in-hypertension
#14
M R Bersi, R Khosravi, A J Wujciak, D G Harrison, J D Humphrey
The embryonic lineage of intramural cells, microstructural organization of the extracellular matrix, local luminal and wall geometry, and haemodynamic loads vary along the length of the aorta. Yet, it remains unclear why certain diseases manifest differentially along the aorta. Toward this end, myriad animal models provide insight into diverse disease conditions-including fibrosis, aneurysm and dissection-but inherent differences across models impede general interpretations. We examined region-specific cellular, matrix, and biomechanical changes in a single experimental model of hypertension and atherosclerosis, which commonly coexist...
November 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/29106999/functional-connectivity-in-the-dorsal-stream-and-between-bilateral-auditory-related-cortical-areas-differentially-contribute-to-speech-decoding-depending-on-spectro-temporal-signal-integrity-and-performance
#15
Stefan Elmer, Jürg Kühnis, Piyush Rauch, Seyed Abolfazl Valizadeh, Lutz Jäncke
Speech processing relies on the interdependence between auditory perception, sensorimotor integration, and verbal memory functions. Functional and structural connectivity between bilateral auditory-related cortical areas (ARCAs) facilitates spectro-temporal analyses, whereas the dynamic interplay between ARCAs and Broca's area (i.e., dorsal pathway) contributes to verbal memory functions, articulation, and sound-to-motor mapping. However, it remains unclear whether these two neural circuits are preferentially driven by spectral or temporal acoustic information, and whether their recruitment is predictive of speech perception performance and learning...
October 30, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/29061907/deubiquitllating-enzyme-otu5-contributes-to-dna-methylation-patterns-and-is-critical-for-phosphate-nutrition-signals
#16
Ming-Ren Yen, Der-Fen Suen, Fei-Man Hsu, Yi-Hsiu Tsai, Hongyong Fu, Wolfgang Schmidt, Pao-Yang Chen
Phosphate (Pi) starvation induces a suite of adaptive responses aimed at recalibrating cellular Pi homeostasis. Plants harboring a mutation in OVARIAN TUMOR DOMAIN-CONTAINING DEUBIQUITILATING ENZYME5 (OTU5) showed altered DNA methylation of root hair-related genes and altered Pi-responsive root traits. Unlike the wild type, homozygous otu5 mutants did not respond to Pi starvation by increased lateral root formation and increased root hair length, but formed very short root hairs when grown on low Pi media. Under Pi-replete conditions, otu5 plants developed more root hairs than the wild type due to attenuated primary root growth, a phenotype which resembled that of Pi-deficient plants...
October 23, 2017: Plant Physiology
https://www.readbyqxmd.com/read/29061170/translating-recent-results-from-the-cardiovascular-outcomes-trials-into-clinical-practice-recommendations-from-the-central-and-eastern-european-diabetes-expert-group-ceedeg
#17
REVIEW
Guntram Schernthaner, Roger Lehmann, Martin Prázný, Leszek Czupryniak, Kristine Ducena, Peter Fasching, Andrej Janež, Avraham Karasik, Peter Kempler, Emil Martinka, Marina V Shestakova, Lea Smirčić Duvnjak, Tsvetalina Tankova
AIMS: These recommendations aim to improve care for patients with type 2 diabetes (T2D) at high cardiovascular (CV) risk in Central and Eastern Europe. Cardiovascular disease (CVD) and/or chronic kidney disease (CKD) are major interdependent comorbidities in patients with T2D, accounting for 50% of mortality. Following recent CV outcomes trial (CVOT) results, including those from EMPA-REG OUTCOME®, LEADER®, SUSTAIN™-6 and, most recently, the CANVAS study, it is essential to develop regional expert consensus recommendations to aid physicians in interpreting these newest data to clinical practice...
October 23, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29041878/-influence-of-sympathetic-denervation-of-the-renal-artery-on-the-level-of-arterial-blood-pressure-cerebral-blood-flow-and-cognitive-function-in-patients-with-resistant-arterial-hypertension
#18
Y N Efimova, A V Lichikaki, B Y Lishmanov
PURPOSE: To study the effect of radiofrequency ablation of renal arteries on regional cerebral blood flow and cognitive function in patients with resistant arterial hypertension (AH). MATERIAL AND METHODS: Transcatheter renal denervation (TRD) was performed in 17 patients with resistant AH. Examination before and after TRD included SPECT with mTc-HMPAO, 24-hours blood pressure (BP) monitoring, and comprehensive neuropsychological testing. Fifteen patients without angiographic signs of carotid atherosclerosis, coronary artery disease and AH, neurological and psychiatric disorders were investigated as control group...
July 2017: Kardiologiia
https://www.readbyqxmd.com/read/29030103/combining-region-and-network-level-brain-behavior-relationships-in-a-structural-equation-model
#19
Taylor Bolt, Emily B Prince, Jason S Nomi, Daniel Messinger, Maria M Llabre, Lucina Q Uddin
Brain-behavior associations in fMRI studies are typically restricted to a single level of analysis: either a circumscribed brain region-of-interest (ROI) or a larger network of brain regions. However, this common practice may not always account for the interdependencies among ROIs of the same network or potentially unique information at the ROI-level, respectively. To account for both sources of information, we combined measurement and structural components of structural equation modeling (SEM) approaches to empirically derive networks from ROI activity, and to assess the association of both individual ROIs and their respective whole-brain activation networks with task performance using three large task-fMRI datasets and two separate brain parcellation schemes...
October 10, 2017: NeuroImage
https://www.readbyqxmd.com/read/28973923/motor-origin-of-temporal-predictions-in-auditory-attention
#20
Benjamin Morillon, Sylvain Baillet
In behavior, action and perception are inherently interdependent. However, the actual mechanistic contributions of the motor system to sensory processing are unknown. We present neurophysiological evidence that the motor system is involved in predictive timing, a brain function that aligns temporal fluctuations of attention with the timing of events in a task-relevant stream, thus facilitating sensory selection and optimizing behavior. In a magnetoencephalography experiment involving auditory temporal attention, participants had to disentangle two streams of sound on the unique basis of endogenous temporal cues...
October 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
keyword
keyword
86050
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"