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Regional interdependence

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https://www.readbyqxmd.com/read/28532881/preliminary-evidence-of-regional-interdependent-inhibition-using-a-diaphragm-release-to-specifically-induce-an-immediate-hypoalgesic-effect-in-the-cervical-spine
#1
Calum A McCoss, Ross Johnston, Darren J Edwards, Charles Millward
In clinical practice, Osteopaths and Manual Therapists commonly direct treatment towards the diaphragm by the use of a 'Diaphragm Release'. Currently, there is paucity within the literature to support the use of this technique, specifically in pain outcomes. This research aims to support a neurophysiological mechanism based upon the osteopathic principle "The body is a unit". Demonstrating that directing treatment to distal tissue which is neurologically related can reduce pain in the originating spinal segments...
April 2017: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/28515010/aberrant-network-activity-in-schizophrenia
#2
REVIEW
Mark J Hunt, Nancy J Kopell, Roger D Traub, Miles A Whittington
Brain dynamic changes associated with schizophrenia are largely equivocal, with interpretation complicated by many factors, such as the presence of therapeutic agents and the complex nature of the syndrome itself. Evidence for a brain-wide change in individual network oscillations, shared by all patients, is largely equivocal, but stronger for lower (delta) than for higher (gamma) bands. However, region-specific changes in rhythms across multiple, interdependent, nested frequencies may correlate better with pathology...
May 14, 2017: Trends in Neurosciences
https://www.readbyqxmd.com/read/28494271/motion-robust-parameter-estimation-in-abdominal-diffusion-weighted-mri-by-simultaneous-image-registration-and-model-estimation
#3
Sila Kurugol, Moti Freiman, Onur Afacan, Liran Domachevsky, Jeannette M Perez-Rossello, Michael J Callahan, Simon K Warfield
Quantitative body DW-MRI can detect abdominal abnormalities as well as monitor response-to-therapy for applications including cancer and inflammatory bowel disease with increased accuracy. Parameter estimates are obtained by fitting a forward model of DW-MRI signal decay to the observed data acquired with several b-values. The DW-MRI signal decay models typically used do not account for respiratory, cardiac and peristaltic motion, however, which may deteriorate the accuracy and robustness of parameter estimates...
May 3, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28486965/site-specific-gene-expression-patterns-in-oral-cancer
#4
Gesche Frohwitter, Horst Buerger, Eberhard Korsching, Paul J van Diest, Johannes Kleinheinz, Thomas Fillies
BACKGROUND: Squamous cell carcinomas (SCCs) are the most prevalent malignant tumours within the head and neck. Evidence exists that distinct genes are differentially regulated in SCCs of the oral cavity compared to other head and neck regions. Given this background, the aim of this study was to investigate whether such tumour site-specific gene expression can also be observed in different localizations within the oral cavity. METHODS: Using tissue microarrays (TMAs), we investigated 76 SCCs of the floor of the mouth, 49 SCCs of the tongue and 68 SCCs of other anatomic regions within the oral cavity...
May 10, 2017: Head & Face Medicine
https://www.readbyqxmd.com/read/28483815/drosophila-dalmatian-combines-sororin-and-shugoshin-roles-in-establishment-and-protection-of-cohesion
#5
Takashi Yamada, Eri Tahara, Mai Kanke, Keiko Kuwata, Tomoko Nishiyama
Sister chromatid cohesion is crucial to ensure chromosome bi-orientation and equal chromosome segregation. Cohesin removal via mitotic kinases and Wapl has to be prevented in pericentromeric regions in order to protect cohesion until metaphase, but the mechanisms of mitotic cohesion protection remain elusive in Drosophila Here, we show that dalmatian (Dmt), an ortholog of the vertebrate cohesin-associated protein sororin, is required for protection of mitotic cohesion in flies. Dmt is essential for cohesion establishment during interphase and is enriched on pericentromeric heterochromatin...
May 8, 2017: EMBO Journal
https://www.readbyqxmd.com/read/28469148/functional-organization-of-protein-determinants-of-meiotic-dna-break-hotspots
#6
Lijuan Ma, Kyle R Fowler, Cristina Martín-Castellanos, Gerald R Smith
During Schizosaccharomyces pombe meiotic prophase, homologous chromosomes are co-aligned by linear elements (LinEs) analogous to the axial elements of the synaptonemal complex (SC) in other organisms. LinE proteins also promote the formation of meiotic DNA double-strand breaks (DSBs), the precursors of cross-overs. Rec10 is required for essentially all DSBs and recombination, and three others (Rec25, Rec27, and Mug20) are protein determinants of DSB hotspots - they bind DSB hotspots with high specificity and are required for DSB formation there...
May 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28449127/effects-of-emotional-valence-and-arousal-on-the-voice-perception-network
#7
Patricia E G Bestelmeyer, Sonja A Kotz, Pascal Belin
Several theories conceptualise emotions along two main dimensions: valence (a continuum from negative to positive) and arousal (a continuum that varies from low to high). These dimensions are typically treated as independent in many neuroimaging experiments, yet recent behavioural findings suggest that they are actually interdependent. This result has impact on neuroimaging design, analysis and theoretical development. We were interested in determining the extent of this interdependence both behaviourally and neuroanatomically, as well as teasing apart any activation that is specific to each dimension...
April 25, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/28445765/in-line-monitoring-and-optimization-of-powder-flow-in-a-simulated-continuous-process-using-transmission-near-infrared-spectroscopy
#8
Md Anik Alam, Zhenqi Shi, James K Drennen, Carl A Anderson
In-line monitoring of continuous powder flow is an integral part of the continuous manufacturing process of solid oral dosage forms in the pharmaceutical industry. Specifically, monitoring downstream from loss-in-weight (LIW) feeders and/or continuous mixers provides important data about the state of the process. Such measurements support control of the process and thereby enhance product quality. Near Infrared Spectroscopy (NIRS) is a potential PAT tool to monitor the homogeneity of a continuous powder flow stream in pharmaceutical manufacturing...
April 23, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28416574/a-glutamate-substituted-mutant-mimics-the-phosphorylated-and-active-form-of-guanylyl-cyclase-a
#9
Neil M Otto, William G McDowell, Deborah M Dickey, Lincoln R Potter
Multisite phosphorylation is required for activation of guanylyl cyclase (GC)-A, also known as NPR-A or NPR1, by cardiac natriuretic peptides (NPs). Seven chemically identified sites (Ser-487, Ser-497, Thr-500, Ser-502, Ser-506, Ser-510, Thr-513) and one functionally identified putative site (Ser-473) were reported. Single alanine substitutions for Ser-497, Thr-500, Ser-502, Ser-506 and Ser-510 reduced maximal velocity (Vmax), while glutamate substitutions had no effect or increased Vmax. Ala but not Glu substitution for Ser-497 increased the Michaelis constant (Km) ~400%...
April 17, 2017: Molecular Pharmacology
https://www.readbyqxmd.com/read/28406379/the-neural-basis-of-independence-versus-interdependence-orientations-a-voxel-based-morphometric-analysis-of-brain-volume
#10
Fei Wang, Kaiping Peng, Magdalena Chechlacz, Glyn W Humphreys, Jie Sui
Sociocultural research has established independence and interdependence as two fundamental ways of thinking about oneself and the social world. Recent neuroscience studies further demonstrate that these orientations modulate brain activity in various self- and socially related tasks. In the current study, we explored whether the traits of independence and interdependence are reflected in anatomical variations in brain structure. We carried out structural brain imaging on a large sample of healthy participants ( n = 265) who also completed self-report questionnaires of cultural orientations...
April 2017: Psychological Science
https://www.readbyqxmd.com/read/28382758/coaching-is-teamwork-the-role-of-need-supportive-coaching-and-the-motivational-climate-in-stimulating-proactivity-in-volleyball-teams
#11
S Van Puyenbroeck, J Stouten, G Vande Broek
Team sports settings are challenging, dynamic environments in which coaches often benefit from proactive players who take initiative in providing valuable suggestions and feedback. Based on self-determination theory and achievement goal theory, this study examined the mediating role of a mastery and performance motivational climate in the positive relation between coaches' psychological need-supportive behavior and team athletes' proactivity. The study sample consisted of 75 male and 105 female volleyball players (Mage =21...
April 6, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28377786/unveiling-the-impact-of-the-genomic-architecture-on-the-evolution-of-vertebrate-micrornas
#12
REVIEW
Gustavo S França, Ludwig C Hinske, Pedro A F Galante, Maria D Vibranovski
Eukaryotic genomes frequently exhibit interdependency between transcriptional units, as evidenced by regions of high gene density. It is well recognized that vertebrate microRNAs (miRNAs) are usually embedded in those regions. Recent work has shown that the genomic context is of utmost importance to determine miRNA expression in time and space, thus affecting their evolutionary fates over long and short terms. Consequently, understanding the inter- and intraspecific changes on miRNA genomic architecture may bring novel insights on the basic cellular processes regulated by miRNAs, as well as phenotypic evolution and disease-related mechanisms...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/28373363/re-engineering-the-pancreas-tumor-microenvironment-a-regenerative-program-hacked
#13
EDITORIAL
Gerard I Evan, Nasun Hah, Trevor D Littlewood, Nicole M Sodir, Tania Campos, Michael Downes, Ronald M Evans
The "hallmarks" of pancreatic ductal adenocarcinoma (PDAC) include proliferative, invasive, and metastatic tumor cells and an associated dense desmoplasia comprised of fibroblasts, pancreatic stellate cells, extracellular matrix, and immune cells. The oncogenically activated pancreatic epithelium and its associated stroma are obligatorily interdependent, with the resulting inflammatory and immunosuppressive microenvironment contributing greatly to the evolution and maintenance of PDAC. The peculiar pancreas-specific tumor phenotype is a consequence of oncogenes hacking the resident pancreas regenerative program, a tissue-specific repair mechanism regulated by discrete super enhancer networks...
April 1, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28346850/risk-factors-related-to-lower-limb-edema-compression-and-physical-activity-during-pregnancy-a-retrospective-study
#14
Katarzyna Ochalek, Katarzyna Pacyga, Marta Curyło, Aleksandra Frydrych-Szymonik, Zbigniew Szygula
OBJECTIVE: The aim of the article was to assess risk factors and to analyze methods applied in the prevention and treatment of lower limb edema in pregnant women with a particular focus on compression therapy and exercise. MATERIALS AND METHODS: Fifty-four women during the early 24-hour period following delivery were assigned to two groups-either to a group with swellings of lower limbs during pregnancy, located mostly in the region of feet and lower legs (Group A, n = 42), or to a group without edema (Group B, n = 12)...
March 27, 2017: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/28344551/construction-and-analysis-of-weighted-brain-networks-from-sice-for-the-study-of-alzheimer-s-disease
#15
Jorge Munilla, Andrés Ortiz, Juan M Górriz, Javier Ramírez
Alzheimer's Disease (AD) is the most common neurodegenerative disease in elderly people, and current drugs, unfortunately, do not represent yet a cure but only slow down its progression. This is explained, at least in part, because the understanding of the neurodegenerative process is still incomplete, being sometimes mistaken, particularly at the first steps of the illness, with the natural aging process. A better identification of how the functional activity deteriorates is thus crucial to develop new and more effective treatments...
2017: Frontiers in Neuroinformatics
https://www.readbyqxmd.com/read/28337662/a83-01-inhibits-tgf-%C3%AE-induced-upregulation-of-wnt3-and-epithelial-to-mesenchymal-transition-in-her2-overexpressing-breast-cancer-cells
#16
Yanyuan Wu, Trinh Tran, Sami Dwabe, Marianna Sarkissyan, Juri Kim, Miguel Nava, Sheilah Clayton, Richard Pietras, Robin Farias-Eisner, Jaydutt V Vadgama
PURPOSE: The aim of this study is to investigate the mechanisms of interactions between TGF-β and Wnt/β-catenin pathways that induce and regulate EMT and promote breast cancer cells to become resistant to treatment. METHODS: The effect of TGF-β on Wnt/β-catenin signaling pathway was examined by using a human Wnt/β-catenin-regulated cDNA plate array and western blot analysis. The interaction of Twist at promoter of Wnt3 was examined by chromatin immunoprecipitation (ChIP) assay...
March 23, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28334680/assessing-driving-forces-of-land-use-and-land-cover-change-by-a-mixed-method-approach-in-north-eastern-ghana-west-africa
#17
Janina Kleemann, Gülendam Baysal, Henry N N Bulley, Christine Fürst
Land use and land cover change (LULCC) is the result of complex human-environmental interactions. The high interdependencies in social-ecological systems make it difficult to identify the main drivers. However, knowledge of key drivers of LULCC, including indirect (underlying) drivers which cannot be easily determined by spatial or economic analyses, is essential for land use planning and especially important in developing countries. We used a mixed-method approach in order to detect drivers of LULCC in the Upper East Region of northern Ghana by different qualitative and quantitative methods which were compared in a confidence level analysis...
March 20, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28334351/effects-of-antenatal-maternal-depressive-symptoms-and-socio-economic-status-on-neonatal-brain-development-are-modulated-by-genetic-risk
#18
Anqi Qiu, Mojun Shen, Claudia Buss, Yap-Seng Chong, Kenneth Kwek, Seang-Mei Saw, Peter D Gluckman, Pathik D Wadhwa, Sonja Entringer, Martin Styner, Neerja Karnani, Christine M Heim, Kieran J O'Donnell, Joanna D Holbrook, Marielle V Fortier, Michael J Meaney
This study included 168 and 85 mother-infant dyads from Asian and United States of America cohorts to examine whether a genomic profile risk score for major depressive disorder (GPRSMDD) moderates the association between antenatal maternal depressive symptoms (or socio-economic status, SES) and fetal neurodevelopment, and to identify candidate biological processes underlying such association. Both cohorts showed a significant interaction between antenatal maternal depressive symptoms and infant GPRSMDD on the right amygdala volume...
May 1, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28273267/-the-complexity-of-articulating-rights-nutrition-and-care
#19
Laura Cecilia Pautassi
This article analyzes the existing tensions between the recognition of human rights - especially the right to adequate food as it is defined in international agreements and treaties - and the insufficient connection made with care, understood as the set of activities necessary to satisfy the basic needs of existence and human and social reproduction. Applying a methodological approach based in rights and gender, the article analyzes, on one hand, the scope of the right to food and its impact at the level of public institutionality, and on the other, the recent recognition of care as a right at a regional level and its persistent invisibilization in public policies...
October 2016: Salud Colectiva
https://www.readbyqxmd.com/read/28267154/natural-hazard-management-from-a-coevolutionary-perspective-exposure-and-policy-response-in-the-european-alps
#20
Sven Fuchs, Veronika Röthlisberger, Thomas Thaler, Andreas Zischg, Margreth Keiler
A coevolutionary perspective is adopted to understand the dynamics of exposure to mountain hazards in the European Alps. A spatially explicit, object-based temporal assessment of elements at risk to mountain hazards (river floods, torrential floods, and debris flows) in Austria and Switzerland is presented for the period from 1919 to 2012. The assessment is based on two different data sets: (1) hazard information adhering to legally binding land use planning restrictions and (2) information on building types combined from different national-level spatial data...
March 4, 2017: Annals of the American Association of Geographers
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