keyword
MENU ▼
Read by QxMD icon Read
search

Regional interdependence

keyword
https://www.readbyqxmd.com/read/29148575/effects-of-spot-parameters-in-pencil-beam-scanning-treatment-planning
#1
Aafke Christine Kraan, Nicolas Depauw, Ben Clasie, Marina Giunta, Tom Madden, Hanne M Kooy
BACKGROUND: Spot size σ (in-air at isocenter), inter-spot spacing d, and spot charge q influence dose delivery efficiency and plan quality in Intensity Modulated Proton Therapy (IMPT) treatment planning. The choice and range of parameters varies among different manufacturers. The goal of this work is to demonstrate the influence of the spot parameters on dose quality and delivery in IMPT treatment plans, to show their interdependence, and to make practitioners aware of the spot parameter values for a certain facility...
November 17, 2017: Medical Physics
https://www.readbyqxmd.com/read/29138620/cutaneous-microflora-from-geographically-isolated-groups-of-bradysia-agrestis-an-insect-vector-of-diverse-plant-pathogens
#2
Jong Myong Park, Young-Hyun You, Jong-Han Park, Hyeong-Hwan Kim, Sa-Youl Ghim, Chang-Gi Back
Larvae of Bradysia agrestis, an insect vector that transports plant pathogens, were sampled from geographically isolated regions in Korea to identify their cutaneous fungal and bacterial flora. Sampled areas were chosen within the distribution range of B. agrestis; each site was more than 91 km apart to ensure geographical segregation. We isolated 76 microbial (fungi and bacteria) strains (site 1, 29; site 2, 29; site 3, 18 strains) that were identified on the basis of morphological differences. Species identification was molecularly confirmed by determination of universal fungal internal transcribed spacer and bacterial 16S rRNA gene sequences in comparison to sequences in the EzTaxon database and the NCBI GenBank database, and their phylogenetic relationships were determined...
September 2017: Mycobiology
https://www.readbyqxmd.com/read/29134248/the-ancient-claudin-dni2-facilitates-yeast-cell-fusion-by-compartmentalizing-dni1-into-a-membrane-subdomain
#3
M-Ángeles Curto, Sandra Moro, Francisco Yanguas, Carmen Gutiérrez-González, M-Henar Valdivieso
Dni1 and Dni2 facilitate cell fusion during mating. Here, we show that these proteins are interdependent for their localization in a plasma membrane subdomain, which we have termed the mating fusion domain. Dni1 compartmentation in the domain is required for cell fusion. The contribution of actin, sterol-dependent membrane organization, and Dni2 to this compartmentation was analysed, and the results showed that Dni2 plays the most relevant role in the process. In turn, the Dni2 exit from the endoplasmic reticulum depends on Dni1...
November 13, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/29125409/interdependence-in-decision-making-by-medical-consultants-implications-for-improving-the-efficiency-of-inpatient-physician-services
#4
Adam S Wilk, Lena M Chen
OBJECTIVES: Hospital administrators are seeking to improve efficiency in medical consultation services, yet whether consultants make decisions to provide more or less care is unknown. We examined how medical consultants account for prior consultants' care when determining whether to provide intensive consulting care or sign off in the treatment of complex surgical inpatients. We applied three distinct theoretical frameworks in the interpretation of our results. METHODS: We performed a retrospective cohort study of consultants' care intensity, measured alternately using a dummy variable for providing two or more days consulting (versus one) and a continuous measure of total days consulting, with 100% Medicare claims data from 2007-2010...
November 10, 2017: Hospital Practice (Minneapolis)
https://www.readbyqxmd.com/read/29121600/use-of-surrogate-indicators-for-the-evaluation-of-potential-health-risks-due-to-poor-urban-water-quality-a-bayesian-network-approach
#5
Buddhi Wijesiri, Kaveh Deilami, James McGree, Ashantha Goonetilleke
Urban water pollution poses risks of waterborne infectious diseases. Therefore, in order to improve urban liveability, effective pollution mitigation strategies are required underpinned by predictions generated using water quality models. However, the lack of reliability in current modelling practices detrimentally impacts planning and management decision making. This research study adopted a novel approach in the form of Bayesian Networks to model urban water quality to better investigate the factors that influence risks to human health...
November 6, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29118111/differential-cell-matrix-mechanoadaptations-and-inflammation-drive-regional-propensities-to-aortic-fibrosis-aneurysm-or-dissection-in-hypertension
#6
M R Bersi, R Khosravi, A J Wujciak, D G Harrison, J D Humphrey
The embryonic lineage of intramural cells, microstructural organization of the extracellular matrix, local luminal and wall geometry, and haemodynamic loads vary along the length of the aorta. Yet, it remains unclear why certain diseases manifest differentially along the aorta. Toward this end, myriad animal models provide insight into diverse disease conditions-including fibrosis, aneurysm and dissection-but inherent differences across models impede general interpretations. We examined region-specific cellular, matrix, and biomechanical changes in a single experimental model of hypertension and atherosclerosis, which commonly coexist...
November 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/29106999/functional-connectivity-in-the-dorsal-stream-and-between-bilateral-auditory-related-cortical-areas-differentially-contribute-to-speech-decoding-depending-on-spectro-temporal-signal-integrity-and-performance
#7
Stefan Elmer, Jürg Kühnis, Piyush Rauch, Seyed Abolfazl Valizadeh, Lutz Jäncke
Speech processing relies on the interdependence between auditory perception, sensorimotor integration, and verbal memory functions. Functional and structural connectivity between bilateral auditory-related cortical areas (ARCAs) facilitates spectro-temporal analyses, whereas the dynamic interplay between ARCAs and Broca's area (i.e., dorsal pathway) contributes to verbal memory functions, articulation, and sound-to-motor mapping. However, it remains unclear whether these two neural circuits are preferentially driven by spectral or temporal acoustic information, and whether their recruitment is predictive of speech perception performance and learning...
October 30, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/29061907/deubiquitllating-enzyme-otu5-contributes-to-dna-methylation-patterns-and-is-critical-for-phosphate-nutrition-signals
#8
Ming-Ren Yen, Der-Fen Suen, Fei-Man Hsu, Yi-Hsiu Tsai, Hongyong Fu, Wolfgang Schmidt, Pao-Yang Chen
Phosphate (Pi) starvation induces a suite of adaptive responses aimed at recalibrating cellular Pi homeostasis. Plants harboring a mutation in OVARIAN TUMOR DOMAIN-CONTAINING DEUBIQUITILATING ENZYME5 (OTU5) showed altered DNA methylation of root hair-related genes and altered Pi-responsive root traits. Unlike the wild type, homozygous otu5 mutants did not respond to Pi starvation by increased lateral root formation and increased root hair length, but formed very short root hairs when grown on low Pi media. Under Pi-replete conditions, otu5 plants developed more root hairs than the wild type due to attenuated primary root growth, a phenotype which resembled that of Pi-deficient plants...
October 23, 2017: Plant Physiology
https://www.readbyqxmd.com/read/29061170/translating-recent-results-from-the-cardiovascular-outcomes-trials-into-clinical-practice-recommendations-from-the-central-and-eastern-european-diabetes-expert-group-ceedeg
#9
REVIEW
Guntram Schernthaner, Roger Lehmann, Martin Prázný, Leszek Czupryniak, Kristine Ducena, Peter Fasching, Andrej Janež, Avraham Karasik, Peter Kempler, Emil Martinka, Marina V Shestakova, Lea Smirčić Duvnjak, Tsvetalina Tankova
AIMS: These recommendations aim to improve care for patients with type 2 diabetes (T2D) at high cardiovascular (CV) risk in Central and Eastern Europe. Cardiovascular disease (CVD) and/or chronic kidney disease (CKD) are major interdependent comorbidities in patients with T2D, accounting for 50% of mortality. Following recent CV outcomes trial (CVOT) results, including those from EMPA-REG OUTCOME(®), LEADER(®), SUSTAIN™-6 and, most recently, the CANVAS study, it is essential to develop regional expert consensus recommendations to aid physicians in interpreting these newest data to clinical practice...
October 23, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29041878/-influence-of-sympathetic-denervation-of-the-renal-artery-on-the-level-of-arterial-blood-pressure-cerebral-blood-flow-and-cognitive-function-in-patients-with-resistant-arterial-hypertension
#10
Y N Efimova, A V Lichikaki, B Y Lishmanov
PURPOSE: To study the effect of radiofrequency ablation of renal arteries on regional cerebral blood flow and cognitive function in patients with resistant arterial hypertension (AH). MATERIAL AND METHODS: Transcatheter renal denervation (TRD) was performed in 17 patients with resistant AH. Examination before and after TRD included SPECT with mTc-HMPAO, 24-hours blood pressure (BP) monitoring, and comprehensive neuropsychological testing. Fifteen patients without angiographic signs of carotid atherosclerosis, coronary artery disease and AH, neurological and psychiatric disorders were investigated as control group...
July 2017: Kardiologiia
https://www.readbyqxmd.com/read/29030103/combining-region-and-network-level-brain-behavior-relationships-in-a-structural-equation-model
#11
Taylor Bolt, Emily B Prince, Jason S Nomi, Daniel Messinger, Maria M Llabre, Lucina Q Uddin
Brain-behavior associations in fMRI studies are typically restricted to a single level of analysis: either a circumscribed brain region-of-interest (ROI) or a larger network of brain regions. However, this common practice may not always account for the interdependencies among ROIs of the same network or potentially unique information at the ROI-level, respectively. To account for both sources of information, we combined measurement and structural components of structural equation modeling (SEM) approaches to empirically derive networks from ROI activity, and to assess the association of both individual ROIs and their respective whole-brain activation networks with task performance using three large task-fMRI datasets and two separate brain parcellation schemes...
October 10, 2017: NeuroImage
https://www.readbyqxmd.com/read/28973923/motor-origin-of-temporal-predictions-in-auditory-attention
#12
Benjamin Morillon, Sylvain Baillet
In behavior, action and perception are inherently interdependent. However, the actual mechanistic contributions of the motor system to sensory processing are unknown. We present neurophysiological evidence that the motor system is involved in predictive timing, a brain function that aligns temporal fluctuations of attention with the timing of events in a task-relevant stream, thus facilitating sensory selection and optimizing behavior. In a magnetoencephalography experiment involving auditory temporal attention, participants had to disentangle two streams of sound on the unique basis of endogenous temporal cues...
October 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28968449/modelling-innovation-performance-of-european-regions-using-multi-output-neural-networks
#13
Petr Hajek, Roberto Henriques
Regional innovation performance is an important indicator for decision-making regarding the implementation of policies intended to support innovation. However, patterns in regional innovation structures are becoming increasingly diverse, complex and nonlinear. To address these issues, this study aims to develop a model based on a multi-output neural network. Both intra- and inter-regional determinants of innovation performance are empirically investigated using data from the 4th and 5th Community Innovation Surveys of NUTS 2 (Nomenclature of Territorial Units for Statistics) regions...
2017: PloS One
https://www.readbyqxmd.com/read/28957537/the-overloaded-right-heart-and-ventricular-interdependence
#14
Robert Naeije, Roberto Badagliacca
The right and the left ventricle are interdependent as both structures are nested within the pericardium, have the septum in common and are encircled with common myocardial fibres. Therefore, right ventricular volume or pressure overloading affects left ventricular function, and this in turn may affect the right ventricle. In normal subjects at rest, right ventricular function has negligible interaction with left ventricular function. However, the right ventricle contributes significantly to the normal cardiac output response to exercise...
October 1, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28921740/5-httlpr-moderates-the-association-between-interdependence-and-brain-responses-to-mortality-threats
#15
Siyang Luo, Dian Yu, Shihui Han
While behavioral research suggests an association between cultural worldview and decreased anxiety of death, the underlying neurobiological mechanisms remain unclear. Using functional MRI, we investigated whether and how the serotonin transporter promoter polymorphism (5-HTTLPR), which has been associated with mental disorders such as anxiety and depression, moderates the associations between a cultural trait (i.e., interdependence) and self-report of death anxiety/depression and between interdependence and brain responses to mortality threats...
September 17, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28900022/binding-of-nad-glycohydrolase-to-streptolysin-o-stabilizes-both-toxins-and-promotes-virulence-of-group-a-streptococcus
#16
Jorge J Velarde, Maghnus O'Seaghdha, Buket Baddal, Benedicte Bastiat-Sempe, Michael R Wessels
The globally dominant, invasive M1T1 strain of group A Streptococcus (GAS) harbors polymorphisms in the promoter region of an operon that contains the genes encoding streptolysin O (SLO) and NAD(+)-glycohydrolase (NADase), resulting in high-level expression of these toxins. While both toxins have been shown experimentally to contribute to pathogenesis, many GAS isolates lack detectable NADase activity. DNA sequencing of such strains has revealed that reduced or absent enzymatic activity can be associated with a variety of point mutations in nga, the gene encoding NADase; a commonly observed polymorphism associated with near-complete abrogation of activity is a substitution of aspartic acid for glycine at position 330 (G330D)...
September 12, 2017: MBio
https://www.readbyqxmd.com/read/28890691/predicting-intentions-of-a-familiar-significant-other-beyond-the-mirror-neuron-system
#17
Stephanie Cacioppo, Elsa Juan, George Monteleone
Inferring intentions of others is one of the most intriguing issues in interpersonal interaction. Theories of embodied cognition and simulation suggest that this mechanism takes place through a direct and automatic matching process that occurs between an observed action and past actions. This process occurs via the reactivation of past self-related sensorimotor experiences within the inferior frontoparietal network (including the mirror neuron system, MNS). The working model is that the anticipatory representations of others' behaviors require internal predictive models of actions formed from pre-established, shared representations between the observer and the actor...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28866441/cardiac-magnetic-resonance-evaluation-of-left-ventricular-myocardial-strain-in-pulmonary-hypertension
#18
Kimberly Kallianos, Gabriel C Brooks, Kanae Mukai, Florent Seguro de Carvalho, Jing Liu, David M Naeger, Teresa De Marco, Karen G Ordovas
RATIONALE AND OBJECTIVES: We investigated the feasibility of detecting left ventricular (LV) cardiac magnetic resonance (CMR) strain abnormalities using feature-tracking in patients with pulmonary hypertension (PH). MATERIALS AND METHODS: CMR was performed in 16 patients with all groups of PH and in 13 controls. Global and regional peak circumferential strains (%) (which have been shown to be robust by CMR), peak diastolic strain rate (%/s), and dyssynchrony index (ms) were quantified with feature-tracking software...
August 30, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28854962/optimized-reduced-representation-bisulfite-sequencing-reveals-tissue-specific-mchh-islands-in-maize
#19
Fei-Man Hsu, Ming-Ren Yen, Chi-Ting Wang, Chien-Yu Lin, Chung-Ju Rachel Wang, Pao-Yang Chen
BACKGROUND: DNA methylation plays important roles in many regulatory processes in plants. It is economically infeasible to profile genome-wide DNA methylation at a single-base resolution in maize, given its genome size of ~2.5 Gb. As an alternative, we adapted region of interest (ROI)-directed reduced representation bisulfite sequencing (RRBS) to survey genome-wide methylation in maize. RESULTS: We developed a pipeline for selecting restriction enzymes in silico and experimentally showed that, in the maize genome, MseI- and CviQI-digested fragments are precisely enriched in promoters and gene bodies, respectively...
August 30, 2017: Epigenetics & Chromatin
https://www.readbyqxmd.com/read/28854358/smc-progressively-aligns-chromosomal-arms-in-caulobacter-crescentus-but-is-antagonized-by-convergent-transcription
#20
Ngat T Tran, Michael T Laub, Tung B K Le
The structural maintenance of chromosomes (SMC) complex plays an important role in chromosome organization and segregation in most living organisms. In Caulobacter crescentus, SMC is required to align the left and the right arms of the chromosome that run in parallel down the long axis of the cell. However, the mechanism of SMC-mediated alignment of chromosomal arms remains elusive. Here, using genome-wide methods and microscopy of single cells, we show that Caulobacter SMC is recruited to the centromeric parS site and that SMC-mediated arm alignment depends on the chromosome-partitioning protein ParB...
August 29, 2017: Cell Reports
keyword
keyword
86050
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"