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Regional interdependence

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https://www.readbyqxmd.com/read/27881774/interactions-between-snap-25-and-synaptotagmin-1-are-involved-in-vesicle-priming-clamping-spontaneous-and-stimulating-evoked-neurotransmission
#1
Melanie Schupp, Jörg Malsam, Marvin Ruiter, Andrea Scheutzow, Keimpe D B Wierda, Thomas H Söllner, Jakob B Sørensen
: Whether interactions between synaptotagmin-1 (syt-1) and the soluble NSF attachment protein receptors (SNAREs) are required during neurotransmission is debated. We examined five SNAP-25 mutations designed to interfere with syt-1 interactions. One mutation, D51/E52/E55A, targeted negative charges within region II of the primary interface (Zhou et al., 2015); two mutations targeted region I (D166A and D166/E170A) and one mutation targeted both (D51/E52/E55/D166A). The final mutation (D186/D193A) targeted C-terminal residues not expected to interact with syt-1...
November 23, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27880018/drought-related-secondary-metabolites-of-barley-hordeum-vulgare-l-leaves-and-their-mqtls
#2
Anna Piasecka, Aneta Sawikowska, Anetta Kuczyńska, Piotr Ogrodowicz, Krzysztof Mikołajczak, Karolina Krystkowiak, Kornelia Gudyś, Justyna Guzy-Wróbelska, Paweł Krajewski, Piotr Kachlicki
Determination of the role of plant secondary metabolites in stress conditions is problematic due to diversity of their structures and complexity of interdependence with different biological pathways. Correlation of the metabolomic data with the genetic background provides essential information on the features of metabolites. LC-MS analysis of leaf metabolites from 100 barley recombinant inbred lines (RILs) revealed that 98 traits among 135 detected phenolic and terpenoid compounds significantly changed the level as a result of drought stress...
November 23, 2016: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/27807831/quantitative-clinical-imaging-methods-for-monitoring-intratumoral-evolution
#3
Joo Yeun Kim, Robert A Gatenby
Solid tumors are multiscale, open, complex, dynamic systems: complex because they have many interacting components, dynamic because both the components and their interactions can change with time, and open because the tumor freely communicates with surrounding and even distant host tissue. Thus, it is not surprising that striking intratumoral variations are commonly observed in clinical imaging such as MRI and CT and that several recent studies found striking regional variations in the molecular properties of cancer cells from the same tumor...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27807131/asymmetrically-localized-proteins-stabilize-basal-bodies-against-ciliary-beating-forces
#4
Brian A Bayless, Domenico F Galati, Anthony D Junker, Chelsea B Backer, Jacek Gaertig, Chad G Pearson
Basal bodies are radially symmetric, microtubule-rich structures that nucleate and anchor motile cilia. Ciliary beating produces asymmetric mechanical forces that are resisted by basal bodies. To resist these forces, distinct regions within the basal body ultrastructure and the microtubules themselves must be stable. However, the molecular components that stabilize basal bodies remain poorly defined. Here, we determine that Fop1 functionally interacts with the established basal body stability components Bld10 and Poc1...
November 21, 2016: Journal of Cell Biology
https://www.readbyqxmd.com/read/27790792/als-associated-endoplasmic-reticulum-proteins-in-denervated-skeletal-muscle-implications-for-motor-neuron-disease-pathology
#5
C M Jesse, E Bushuven, P Tripathi, A Chandrasekar, C M Simon, C Drepper, A Yamoah, A Dreser, I Katona, S Johann, C Beyer, S Wagner, M Grond, S Nikolin, J Anink, D Troost, M Sendtner, A Goswami, J Weis
Alpha-motoneurons and muscle fibers are structurally and functionally interdependent. Both cell types particularly rely on endoplasmic reticulum (ER/SR) functions. Mutations of the ER proteins VAPB, SigR1 and HSP27 lead to hereditary motor neuron diseases (MNDs). Here, we determined the expression profile and localization of these ER proteins/chaperons by immunohistochemistry and immunoblotting in biopsy and autopsy muscle tissue of patients with amyotrophic lateral sclerosis (ALS) and other neurogenic muscular atrophies (NMAs) and compared these patterns to mouse models of neurogenic muscular atrophy...
October 28, 2016: Brain Pathology
https://www.readbyqxmd.com/read/27783854/neurocardiology-structure-based-function
#6
Jeffrey L Ardell, John Andrew Armour
Cardiac control is mediated via a series of reflex control networks involving somata in the (i) intrinsic cardiac ganglia (heart), (ii) intrathoracic extracardiac ganglia (stellate, middle cervical), (iii) superior cervical ganglia, (iv) spinal cord, (v) brainstem, and (vi) higher centers. Each of these processing centers contains afferent, efferent, and local circuit neurons, which interact locally and in an interdependent fashion with the other levels to coordinate regional cardiac electrical and mechanical indices on a beat-to-beat basis...
September 15, 2016: Comprehensive Physiology
https://www.readbyqxmd.com/read/27781010/the-paradox-of-happiness-health-and-human-rights-in-the-kingdom-of-bhutan
#7
Benjamin Mason Meier, Averi Chakrabarti
The Kingdom of Bhutan is seeking to progressively realize the human right to health without addressing the cross-cutting human rights principles essential to a rights-based approach to health. Through a landscape analysis of the Bhutanese health system, documentary review of Bhutanese reporting to the United Nations human rights system, and semi-structured interviews with health policymakers in Bhutan, this study examines the normative foundations of Bhutan's focus on "a more meaningful purpose for development than just mere material satisfaction...
June 2016: Health and Human Rights
https://www.readbyqxmd.com/read/27777722/nuclear-mitochondrial-epistasis-a-gene-s-eye-view-of-genomic-conflict
#8
Michael J Wade, Devin M Drown
We use population genetic models to investigate the cooperative and conflicting synergistic fitness effects between genes from the nucleus and the mitochondrion. By varying fitness parameters, we examine the scope for conflict relative to cooperation among genomes and the utility of the "gene's eye view" analytical approach, which is based on the marginal average fitness of specific alleles. Because sexual conflict can maintain polymorphism of mitochondrial haplotypes, we can explore two types of evolutionary conflict (genomic and sexual) with one epistatic model...
September 2016: Ecology and Evolution
https://www.readbyqxmd.com/read/27725003/consanguinity-by-random-isonymy-and-socioeconomic-development-in-argentina-a-population-study
#9
José Edgardo Dipierri, Alvaro Rodríguez-Larralde, Italo Barrai, Esperanza Gutiérrez Redomero, Concepción Alonso-Rodríguez, Emma Laura Alfaro
In human populations various flexible, labile and interdependent structures (genetic, demographic, socioeconomic) co-exist, each of which can be organized in an hierarchical order corresponding to administrative entities. The relationship between consanguinity, as estimated by random isonymy (F ST), and socioeconomic conditions was analysed at different levels of political and administrative organization in Argentina. From the surnames of 22,666,139 voters from the 2001 electoral roll, F ST was estimated for 510 Argentinian departments...
October 11, 2016: Journal of Biosocial Science
https://www.readbyqxmd.com/read/27714786/transfer-frequency-as-a-measure-of-hospital-capability-and-regionalization
#10
Urbano L França, Michael L McManus
OBJECTIVE: To provide metrics for quantifying the capability of hospitals and the degree of care regionalization. DATA SOURCE: Administrative database covering more than 10 million hospital encounters during a 3-year period (2012-2014) in Massachusetts. PRINCIPAL FINDINGS: We calculated the condition-specific probabilities of transfer for all acute care hospitals in Massachusetts and devised two new metrics, the Hospital Capability Index (HCI) and the Regionalization Index (RI), for analyzing hospital systems...
October 7, 2016: Health Services Research
https://www.readbyqxmd.com/read/27695385/the-functional-overlap-of-executive-control-and-language-processing-in-bilinguals
#11
Emily L Coderre, Jason F Smith, Walter J B van Heuven, Barry Horwitz
The need to control multiple languages is thought to require domain-general executive control (EC) in bilinguals such that the EC and language systems become interdependent. However, there has been no systematic investigation into how and where EC and language processes overlap in the bilingual brain. If the concurrent recruitment of EC during bilingual language processing is domain-general and extends to non-linguistic EC, we hypothesize that regions commonly involvement in language processing, linguistic EC, and non-linguistic EC may be selectively altered in bilinguals compared to monolinguals...
May 2016: Bilingualism: Language and Cognition
https://www.readbyqxmd.com/read/27678351/pathophysiology-of-colorectal-peritoneal-carcinomatosis-role-of-the-peritoneum
#12
REVIEW
Lieselotte Lemoine, Paul Sugarbaker, Kurt Van der Speeten
Colorectal cancer (CRC) is the third most common cancer and the fourth most common cause of cancer-related death worldwide. Besides the lymphatic and haematogenous routes of dissemination, CRC frequently gives rise to transcoelomic spread of tumor cells in the peritoneal cavity, which ultimately leads to peritoneal carcinomatosis (PC). PC is associated with a poor prognosis and bad quality of life for these patients in their terminal stages of disease. A loco-regional treatment modality for PC combining cytoreductive surgery and hyperthermic intraperitoneal peroperative chemotherapy has resulted in promising clinical results...
September 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27669647/the-tail-that-wags-the-dog-how-the-disordered-c-terminal-domain-controls-the-transcriptional-activities-of-the-p53-tumor-suppressor-protein
#13
Oleg Laptenko, David R Tong, James Manfredi, Carol Prives
The p53 tumor suppressor is a transcription factor (TF) that exerts antitumor functions through its ability to regulate the expression of multiple genes. Within the p53 protein resides a relatively short unstructured C-terminal domain (CTD) that remarkably participates in virtually every aspect of p53 performance as a TF. Because these aspects are often interdependent and it is not always possible to dissect them experimentally, there has been a great deal of controversy about the CTD. In this review we evaluate the significance and key features of this interesting region of p53 and its impact on the many aspects of p53 function in light of previous and more recent findings...
September 23, 2016: Trends in Biochemical Sciences
https://www.readbyqxmd.com/read/27604738/assessment-of-cognitive-function-in-the-water-maze-task-maximizing-data-collection-and-analysis-in-animal-models-of-brain-injury
#14
Mark D Whiting, Olga N Kokiko-Cochran
Animal models play a critical role in understanding the biomechanical, pathophysiological, and behavioral consequences of traumatic brain injury (TBI). In preclinical studies, cognitive impairment induced by TBI is often assessed using the Morris water maze (MWM). Frequently described as a hippocampally dependent spatial navigation task, the MWM is a highly integrative behavioral task that requires intact functioning in numerous brain regions and involves an interdependent set of mnemonic and non-mnemonic processes...
2016: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27575298/the-poor-lonesome-a-subgenome-of-brassica-napus-var-darmor-aacc-may-not-survive-without-its-mate
#15
Alexandre Pelé, Gwenn Trotoux, Frédérique Eber, Maryse Lodé, Marie Gilet, Gwenaelle Deniot, Cyril Falentin, Sylvie Nègre, Jérôme Morice, Mathieu Rousseau-Gueutin, Anne-Marie Chèvre
Constitutive genomes of allopolyploid species evolve throughout their life span. However, the consequences of long-term alterations on the interdependency between each original genome have not been established. Here, we attempted an approach corresponding to subgenome extraction from a previously sequenced natural allotetraploid, offering a unique opportunity to evaluate plant viability and structural evolution of one of its diploid components. We employed two different strategies to extract the diploid AA component of the Brassica napus variety 'Darmor' (AACC, 2n = 4x = 38) and we assessed the genomic structure of the latest AA plants obtained (after four to five rounds of selection), using a 60K single nucleotide polymorphism Illumina array...
August 30, 2016: New Phytologist
https://www.readbyqxmd.com/read/27525182/using-the-selective-functional-movement-assessment-and-regional-interdependence-theory-to-guide-treatment-of-an-athlete-with-back-pain-a-case-report
#16
Gabriella R Goshtigian, Brian T Swanson
BACKGROUND: Despite the multidirectional quality of human movement, common measurement procedures used in physical therapy examination are often uni-planar and lack the ability to assess functional complexities involved in daily activities. Currently, there is no widely accepted, validated standard to assess movement quality. The Selective Functional Movement Assessment (SFMA) is one possible system to objectively assess complex functional movements. The purpose of this case report is to illustrate the application of the SFMA as a guide to the examination, evaluation, and management of a patient with non-specific low back pain (LBP)...
August 2016: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/27497814/how-does-vagal-nerve-stimulation-vns-change-eeg-brain-functional-connectivity
#17
Fabrice Bartolomei, Francesca Bonini, Elsa Vidal, Agnes Trébuchon, Stanislas Lagarde, Isabelle Lambert, Aileen McGonigal, Didier Scavarda, Romain Carron, Christian G Benar
An effect of vagal nerve stimulation (VNS) on cortical synchronization has been postulated but remains to be verified. In this study we investigated the impact of VNS on functional connectivity (Fc) using direct intracerebral recordings (stereotactic EEG, SEEG). Five patients with epilepsy who underwent SEEG recordings during ongoing VNS therapy were investigated. Interdependencies between twenty-six selected bipolar SEEG channels were estimated by nonlinear regression analysis during ON and OF periods of stimulation...
October 2016: Epilepsy Research
https://www.readbyqxmd.com/read/27486184/patient-perspectives-on-a-personally-controlled-electronic-health-record-used-in-regional-australia-i-can-be-like-my-own-doctor
#18
Lisa Hanna, Stephen D Gill, Laura Newstead, Melanie Hawkins, Richard H Osborne
BACKGROUND: Personally controlled electronic health records (PCEHRs) are being implemented throughout Australia; yet few studies have investigated patients' experiences of using a PCEHR. AIM: To explore patients' experiences and perspectives of using a locally developed PCEHR implemented in an Australian health service. METHOD: Twelve patients completed individual semi-structured telephone interviews, which underwent inductive analysis. RESULTS: Participants described two main interdependent advantages of PCEHRs: improved quality of healthcare through better information sharing and enhanced patient capacity for self-management...
August 2, 2016: HIM Journal
https://www.readbyqxmd.com/read/27412812/modulation-of-chromatin-function-through-linker-histone-h1-variants
#19
REVIEW
Andrzej Kowalski, Jan Pałyga
In this review, the structural aspects of linker H1 histones are presented as a background for characterization of the factors influencing their function in animal and human chromatin. The action of H1 histone variants is largely determined by dynamic alterations of their intrinsically disordered tail domains, posttranslational modifications and allelic diversification. The interdependent effects of these factors can establish dynamic histone H1 states that may affect the organization and function of chromatin regions...
December 2016: Biology of the Cell
https://www.readbyqxmd.com/read/27397568/spatiotemporal-organization-and-cross-frequency-coupling-of-sleep-spindles-in-primate-cerebral-cortex
#20
Saori Takeuchi, Rie Murai, Hideki Shimazu, Yoshikazu Isomura, Tatsuya Mima, Toru Tsujimoto
STUDY OBJECTIVES: The sleep spindle has been implicated in thalamic sensory gating, cortical development, and memory consolidation. These multiple functions may depend on specific spatiotemporal emergence and interactions with other spindles and other forms of brain activity. Therefore, we measured sleep spindle cortical distribution, regional heterogeneity, synchronization, and phase relationships with other electroencephalographic components in freely moving primates. METHODS: Transcortical field potentials were recorded from Japanese monkeys via telemetry and were analyzed using the Hilbert-Huang transform...
2016: Sleep
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