keyword
https://read.qxmd.com/read/38533337/microbial-diversity-in-camel-milk-from-xinjiang-china-as-revealed-by-metataxonomic-analysis
#1
JOURNAL ARTICLE
Miao Sun, Wei Shao, Zhengyu Liu, Xianlan Ma, He Chen, Nan Zheng, Yankun Zhao
The quality of raw camel milk is affected by its bacterial composition and diversity. However, few studies have investigated the bacterial composition and diversity of raw camel milk. In this study, we obtained 20 samples of camel milk during spring and summer in Urumqi and Hami, Xinjiang, China. Single-molecule real-time sequencing technology was used to analyze the bacterial community composition. The results revealed that there were significant seasonal differences in the bacterial composition and diversity of camel milk...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38509572/modifications-of-the-5-region-of-the-caspon-tm-tag-s-mrna-further-enhance-soluble-recombinant-protein-production-in-escherichia-coli
#2
JOURNAL ARTICLE
Christoph Köppl, Wolfgang Buchinger, Gerald Striedner, Monika Cserjan-Puschmann
BACKGROUND: Escherichia coli is one of the most commonly used host organisms for the production of biopharmaceuticals, as it allows for cost-efficient and fast recombinant protein expression. However, challenging proteins are often produced with low titres or as inclusion bodies, and the manufacturing process needs to be developed individually for each protein. Recently, we developed the CASPONTM technology, a generic fusion tag-based platform process for high-titer soluble expression including a standardized downstream processing and highly specific enzymatic cleavage of the fusion tag...
March 20, 2024: Microbial Cell Factories
https://read.qxmd.com/read/38494098/adora2a-downregulation-promotes-caffeine-neuroprotective-effect-against-lps-induced-neuroinflammation-in-the-hippocampus
#3
JOURNAL ARTICLE
Paula Lemes Dos Santos Sanna, Liebert Bernardes Carvalho, Camila Cristina Dos Santos Afonso, Kassia de Carvalho, Rogério Aires, Jennyffer Souza, Marcel Rodrigues Ferreira, Alexander Birbrair, Maria Martha Bernardi, Alexandra Latini, Rodrigo A Foganholi da Silva
Caffeine has been extensively studied in the context of CNS pathologies as many researchers have shown that consuming it reduces pro-inflammatory biomarkers, potentially delaying the progression of neurodegenerative pathologies. Several lines of evidence suggest that adenosine receptors, especially A1 and A2 A receptors, are the main targets of its neuroprotective action. We found that caffeine pretreatment 15 min before LPS administration reduced the expression of Il1b in the hippocampus and striatum...
March 15, 2024: Brain Research
https://read.qxmd.com/read/38462677/land-surface-conductance-linked-to-precipitation-co-evolution-of-vegetation-and-climate-in-earth-system-models
#4
JOURNAL ARTICLE
Peter J Franks, Nicholas Herold, Gordon B Bonan, Keith W Oleson, Jeffrey S Dukes, Matthew Huber, Julian I Schroeder, Peter M Cox, Simon Jones
Vegetation and precipitation are known to fundamentally influence each other. However, this interdependence is not fully represented in climate models because the characteristics of land surface (canopy) conductance to water vapor and CO2 are determined independently of precipitation. Working within a coupled atmosphere and land modelling framework (CAM6/CLM5; coupled Community Atmosphere Model v6/Community Land Model v5), we have developed a new theoretical approach to characterizing land surface conductance by explicitly linking its dynamic properties to local precipitation, a robust proxy for moisture available to vegetation...
March 2024: Global Change Biology
https://read.qxmd.com/read/38456967/multivalent-coiled-coil-interactions-enable-full-scale-centrosome-assembly-and-strength
#5
JOURNAL ARTICLE
Manolo U Rios, Małgorzata A Bagnucka, Bryan D Ryder, Beatriz Ferreira Gomes, Nicole E Familiari, Kan Yaguchi, Matthew Amato, Weronika E Stachera, Łukasz A Joachimiak, Jeffrey B Woodruff
The outermost layer of centrosomes, called pericentriolar material (PCM), organizes microtubules for mitotic spindle assembly. The molecular interactions that enable PCM to assemble and resist external forces are poorly understood. Here, we use crosslinking mass spectrometry (XL-MS) to analyze PLK-1-potentiated multimerization of SPD-5, the main PCM scaffold protein in C. elegans. In the unassembled state, SPD-5 exhibits numerous intramolecular crosslinks that are eliminated after phosphorylation by PLK-1. Thus, phosphorylation induces a structural opening of SPD-5 that primes it for assembly...
April 1, 2024: Journal of Cell Biology
https://read.qxmd.com/read/38455142/testing-effects-of-bottom-up-factors-grazing-and-competition-on-new-zealand-rocky-intertidal-algal-communities
#6
JOURNAL ARTICLE
Barbara J Spiecker, Bruce A Menge
Top-down and bottom-up factors and their interaction highlight the interdependence of resources and consumer impacts on food webs and ecosystems. Variation in the strength of upwelling-mediated ecological controls (i.e., light availability and herbivory) between early and late succession stages is less well understood from the standpoint of influencing algal functional group composition. We experimentally tested the effect of light, grazing, and disturbance on rocky intertidal turf-forming algal communities...
March 2024: Ecology and Evolution
https://read.qxmd.com/read/38452619/synergistic-evolution-of-water-energy-food-system-resilience-and-efficiency-in-urban-agglomerations
#7
JOURNAL ARTICLE
Hui An, Xiangyang Li, Jin Huang, Hailin Wu
With increasing internal and external risks to the WEF system, a single emphasis on efficiency or a lopsided pursuit of resilience can lead to difficulties in adapting to complex changes and resource redundancy. Revealing the synergistic evolutionary characteristics between efficiency and resilience of the WEF system is an effective method to deal with systemic internal and external risks. However, the current study of the WEF system lacks a synergistic perspective on resilience and efficiency. Thus, taking Chengdu-Chongqing Economic Circle (CCEC) as the research object and its geospatial boundary as the system boundary, this paper adopted the entropy-topsis model to evaluate the WEF resilience, and applied the super-efficient SBM model to measure the WEF efficiency accurately, which fully considered the non-expected outputs in the process of resource utilization...
March 6, 2024: Journal of Environmental Management
https://read.qxmd.com/read/38441978/unveiling-the-co-phylogeny-signal-between-plunderfish-harpagifer-spp-and-their-gut-microbiomes-across-the-southern-ocean
#8
JOURNAL ARTICLE
Guillaume Schwob, Léa Cabrol, Thomas Saucède, Karin Gérard, Elie Poulin, Julieta Orlando
UNLABELLED: Understanding the factors that sculpt fish gut microbiome is challenging, especially in natural populations characterized by high environmental and host genomic complexity. However, closely related hosts are valuable models for deciphering the contribution of host evolutionary history to microbiome assembly, through the underscoring of phylosymbiosis and co-phylogeny patterns. Here, we propose that the recent diversification of several Harpagifer species across the Southern Ocean would allow the detection of robust phylogenetic congruence between the host and its microbiome...
March 5, 2024: Microbiology Spectrum
https://read.qxmd.com/read/38432818/a-novel-manual-therapy-approach-for-managing-acute-interscapular-pain-following-median-sternotomy-for-open-cardiac-surgery-a-clinical-comparative-analysis
#9
Francesco Lena, Simone Cesarano, Annalisa D'Onghia, Monica Torre, Marco Santilli, Nicola Modugno, Mohammad Al-Wardat
INTRODUCTION: Acute interscapular pain is a frequent postoperative complication observed in patients who have undergone median sternotomy. This study aimed to assess a novel approach to manual therapy utilizing the Regional Interdependence (RI) concept for managing interscapular pain in post-sternotomy patients. MATERIALS AND METHODS: In an observational study, a cohort of 60 consecutively admitted patients undergoing median sternotomy was enrolled. Data collection involved standardized clinical evaluations conducted at specific time points: prior to manual treatment (T0), following five manual treatments (T5), and at post-treatment days 10 (T10) and 30 (T30)...
January 2024: Journal of Bodywork and Movement Therapies
https://read.qxmd.com/read/38399310/repurposed-drugs-that-activate-autophagy-in-filarial-worms-act-as-effective-macrofilaricides
#10
JOURNAL ARTICLE
Denis Voronin, Nancy Tricoche, Ricardo Peguero, Anna Maria Kaminska, Elodie Ghedin, Judy A Sakanari, Sara Lustigman
Onchocerciasis and lymphatic filariasis are two neglected tropical diseases caused by filarial nematodes that utilize insect vectors for transmission to their human hosts. Current control strategies are based on annual or biannual mass drug administration (MDA) of the drugs Ivermectin or Ivermectin plus Albendazole, respectively. These drug regimens kill the first-stage larvae of filarial worms (i.e., microfilariae) and interrupt the transmission of infections. MDA programs for these microfilaricidal drugs must be given over the lifetime of the filarial adult worms, which can reach 15 years in the case of Onchocerca volvulus ...
February 9, 2024: Pharmaceutics
https://read.qxmd.com/read/38396721/synergy-of-mutation-induced-effects-in-human-vitamin-k-epoxide-reductase-perspectives-and-challenges-for-allo-network-modulator-design
#11
JOURNAL ARTICLE
Marina Botnari, Luba Tchertanov
The human Vitamin K Epoxide Reductase Complex (hVKORC1), a key enzyme transforming vitamin K into the form necessary for blood clotting, requires for its activation the reducing equivalents delivered by its redox partner through thiol-disulfide exchange reactions. The luminal loop (L-loop) is the principal mediator of hVKORC1 activation, and it is a region frequently harbouring numerous missense mutations. Four L-loop hVKORC1 mutants, suggested in vitro as either resistant (A41S, H68Y) or completely inactive (S52W, W59R), were studied in the oxidised state by numerical approaches (in silico)...
February 7, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38387581/understanding-drought-propagation-through-coupling-spatiotemporal-features-using-vine-copulas-a-compound-drought-perspective
#12
JOURNAL ARTICLE
Guibin Yang, Jianxia Chang, Yimin Wang, Aijun Guo, Lu Zhang, Kai Zhou, Zhenwei Wang
Accurately evaluating drought impact on agriculture poses a challenge to regional food security, particularly in compound drought (i.e., meteorological and agricultural drought co-occurring) scenarios. This study presents a novel approach utilizing Vine copula for coupling spatiotemporal features to evaluate drought propagation. Three-dimensional clustering method was employed to identify meteorological and agricultural drought events, which excelled in capturing dynamic evolution characteristics (duration, area, severity, etc...
February 20, 2024: Science of the Total Environment
https://read.qxmd.com/read/38377110/spatial-and-temporal-distribution-characteristics-and-influencing-factors-of-tourism-eco-efficiency-in-the-yellow-river-basin-based-on-the-geographical-and-temporal-weighted-regression-model
#13
JOURNAL ARTICLE
Donghui Peng, Zongzheng Liang, Yapeng Ding, Liuke Liang, Aohui Zhai, Yan Zhang, Xu Gong
With economic progression in China, Yellow River Basin serves as a critical economic belt, which has also been recognized as a cradle of Chinese culture. A watershed is a complex structure of social, economic, and natural factors, and the diversity of its components determines its complexity. Studies on the spatiotemporal distribution characteristics and factors influencing the tourism eco-efficiency at the watershed scale are crucial for the sustainable regional socio-economic development, maintaining a virtuous cycle of various ecosystems, and comprehensively considering the utilization and coordinated development of various elements...
2024: PloS One
https://read.qxmd.com/read/38371710/one-independent-or-many-independent-the-relationship-among-self-construal-number-of-brand-endorsers-and-brand-attitudes
#14
JOURNAL ARTICLE
Shichang Liang, Kunhan Cai, Yiwei Zhang, Xueying Yuan, Siyu Pan, Lili Teng
INTRODUCTION: It was common for brands to use different numbers of endorsers in marketing practice. Nevertheless, research on brand endorsers' quantity has not yielded a uniform consensus. The previous research about brand endorsers mainly focuses on the appeal of endorsement, brand category, and endorser characteristics, paying less attention to the impact of cultural factors, particularly self-construal. This study delves into selecting brand endorsers across diverse cultural regions for the same brand...
2024: Frontiers in Psychology
https://read.qxmd.com/read/38359656/regional-differences-in-field-dependent-independent-cognitive-styles-in-saudi-arabia
#15
JOURNAL ARTICLE
Albandri Sultan Alotaibi
BACKGROUNDS: The primary aim of this study was two-fold: to assess the reliability of the Leuven Embedded Figure Test (L-EFT) in Saudi Arabia (Study 1), and to explore regional differences in independent-interdependent cognitive styles among adults in various regions of Saudi Arabia (Study 2). METHOD: Both Study-1 and Study-2 were structured cross-sectionally. Study 1 involved 360 participants (97 % female) with a median age of 22.51 ± 3.45. Participants completed a demographic questionnaire and the L-EFT task...
February 14, 2024: Acta Psychologica
https://read.qxmd.com/read/38356513/assessment-of-technology-based-options-for-climate-neutrality-in-austrian-manufacturing-industry
#16
JOURNAL ARTICLE
P Nagovnak, C Schützenhofer, M Rahnama Mobarakeh, R Cvetkovska, S Stortecky, A Hainoun, V Alton, T Kienberger
The goals set forth by the European Green Deal require extensive preparation and coordination of all stakeholders. As a valuable tool, energy scenarios can generate the necessary information for stakeholders to envision the right steps in preparing this transition. The manufacturing industries represent an especially important sector to investigate. They are responsible for both high energy consumption and GHG emission figures on the one hand side and provide great economic value for member countries on the other...
February 15, 2024: Heliyon
https://read.qxmd.com/read/38318075/mining-significant-local-spatial-association-rules-for-multi-category-point-data
#17
JOURNAL ARTICLE
Fei Cai, Jie Chen, Telin Chen, Banghua Zhang, Wenping Fan
Spatial association rule mining can reveal the inherent laws of spatial object interdependence and is an important part of spatial data mining. Most of the existing algorithms for mining local spatial association rules are oriented towards the spatial association between two categories of points and cannot fully reflect the spatial heterogeneity of complex spatial relations among multiple categories of points. In addition, the interactions between points in different categories are often asymmetrical. However, the existing algorithms ignore this asymmetry...
February 15, 2024: Heliyon
https://read.qxmd.com/read/38290401/hub-and-spoke-next-level-in-regional-networks-for-infection-prevention
#18
JOURNAL ARTICLE
Daniele Pantano, Alexander W Friedrich
The threat of multidrug-resistant organisms (MDROs) and antimicrobial resistance (AMR) are real and increasing every day. They affect not only healthcare systems but also communities, causing economic and public health concerns. Governments must take action to tackle AMR and prevent the spread of MDROs and regional hubs have a critical role to play in achieving this outcome. Furthermore, bacteria have no borders, consequently, cooperation networks should be extended between countries as a crucial strategy for achieving the success of infection control...
January 26, 2024: International Journal of Medical Microbiology: IJMM
https://read.qxmd.com/read/38288753/highlighting-the-interdependence-between-volumetric-contribution-of-fragility-and-cooperativity-for-polymeric-segmental-relaxation
#19
JOURNAL ARTICLE
Jules Trubert, Liubov Matkovska, Allisson Saiter-Fourcin, Laurent Delbreilh
The blurring around the link between the isobaric fragility and the characteristic size of cooperative rearranging region for glass-forming liquids has been cleared up by considering volumetric and thermal contributions of the structural relaxation. The measurement of these contributions is carried out for three amorphous thermoplastic polymers using broadband dielectric spectroscopy under pressure, providing an understanding of the link between isobaric fragilities, glass transition temperatures, and microstructures...
January 28, 2024: Journal of Chemical Physics
https://read.qxmd.com/read/38280691/neurophysiological-processes-reflecting-the-effects-of-the-immediate-past-during-the-dynamic-management-of-actions
#20
JOURNAL ARTICLE
Tina Rawish, Paul Wendiggensen, Julia Friedrich, Christian Frings, Alexander Münchau, Christian Beste
In recent years, there has been many efforts to establish a comprehensive theoretical framework explaining the working mechanisms involved in perception-action integration. This framework stresses the importance of the immediate past on mechanisms supporting perception-action integration. The present study investigates the neurophysiological principles of dynamic perception-action bindings, particularly considering the influence of the immediate history on action control mechanisms. For this purpose, we conducted an established stimulus-response binding paradigm during EEG recording...
March 2024: NeuroImage
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