Nadir Yehya, Thomas J Booth, Gnana D Ardhanari, Jill M Thompson, L K Metthew Lam, Jacob E Till, Mark V Mai, Garrett Keim, Daniel J McKeone, E Scott Halstead, Patrick Lahni, Brian M Varisco, Wanding Zhou, Erica L Carpenter, Jason D Christie, Nilam S Mangalmurti
BACKGROUND: The molecular signature of pediatric acute respiratory distress syndrome (ARDS) is poorly described, and the degree to which hyperinflammation or specific tissue injury contributes to outcomes is unknown. Therefore, we profiled inflammation and tissue injury dynamics over the first 7 days of ARDS, and associated specific biomarkers with mortality, persistent ARDS, and persistent multiple organ dysfunction syndrome (MODS). METHODS: In a single-center prospective cohort of intubated pediatric ARDS, we collected plasma on days 0, 3, and 7...
April 4, 2024: Journal of Clinical Investigation