keyword
MENU ▼
Read by QxMD icon Read
search

ARDS model

keyword
https://www.readbyqxmd.com/read/28708421/relationship-between-race-and-the-effect-of-fluids-on-long-term-mortality-after-acute-respiratory-distress-syndrome-secondary-analysis-of-the-nhlbi-fluid-and-catheter-treatment-trial
#1
Sarah E Jolley, Catherine L Hough, Gilles Clermont, Douglas Hayden, Suqin Hou, David Schoenfeld, Nicholas L Smith, Boyd Taylor Thompson, Gordon R Bernard, Derek C Angus
RATIONALE: Short-term follow up in the Fluid and Catheter Treatment Trial (FACTT) suggested differential mortality by race with conservative fluid management, but no significant interaction. OBJECTIVE: In a post-hoc analysis of FACTT including one-year follow up, we sought to estimate long-term mortality by race and test for an interaction between fluids and race. METHODS: Post-hoc analysis of FACTT and the Economic Analysis of Pulmonary Artery Catheters (EAPAC) study (included 655 of the 1000 FACTT patients with near complete one-year follow up)...
July 14, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28701843/incidence-proportion-of-acute-cor-pulmonale-in-patients-with-acute-respiratory-distress-syndrome-subjected-to-lung-protective-ventilation-a-systematic-review-and-meta-analysis
#2
Saurabh Kumar Das, Nang Sujali Choupoo, Priyam Saikia, Amitabh Lahkar
INTRODUCTION: Reported incidence of acute cor pulmonale (ACP) in patients with acute respiratory distress syndrome (ARDS) varies from 10% to 84%, despite being subjected to lung protective ventilation according to the current guidelines. The objective of this review is to find pooled cumulative incidence of ACP in patients with ARDS undergoing lung protective ventilation. MATERIALS AND METHODS: We searched MEDLINE, EMBASE, Cochrane Library, KoreaMed, LILACS, and WHO Clinical Trial Registry...
June 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28684908/%C3%AE-bisabolol-loaded-lipid-core-nanocapsules-reduce-lipopolysaccharide-induced-pulmonary-inflammation-in-mice
#3
Ana Paula L D'Almeida, Maria T Pacheco de Oliveira, Éverton T de Souza, Diego de Sá Coutinho, Bianca T Ciambarella, Cristiano R Gomes, Thatiana Terroso, Sílvia S Guterres, Adriana R Pohlmann, Patrícia Mr Silva, Marco A Martins, Andressa Bernardi
Acute respiratory distress syndrome (ARDS) is a severe clinical condition of respiratory failure due to an intense inflammatory response with different etiologies. Despite all efforts, therapy remains limited, and ARDS is still associated with high mortality and morbidity. Plants can provide a vast source of active natural products for the discovery of new drugs. α-bisabolol (α-bis), a constituent of the essential oil from chamomile, has elicited pharmacological interest. However, the molecule has some limitations to its biological application...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28678521/restoration-of-megalin-mediated-clearance-of-alveolar-protein-as-a-novel-therapeutic-approach-for-acute-lung-injury
#4
Christine U Vohwinkel, Yasmin Buchäckert, Hamza M Al-Tamari, Luciana C Mazzocchi, Holger K Eltzschig, Konstantin Mayer, Rory E Morty, Susanne Herold, Werner Seeger, Soni S Pullamsetti, István Vadász
Acute respiratory distress syndrome (ARDS) constitutes a significant disease burden with regard to both morbidity and mortality. Current therapies are mostly supportive and do not address the underlying pathophysiologic mechanisms. Removal of protein-rich alveolar edema - a clinical hallmark of ARDS - is critical for survival. Here, we describe a TGFβ-triggered mechanism, in which megalin, the primary mediator of alveolar protein transport, is negatively regulated by GSK3β, with protein phosphatase 1 (PP1) and nuclear inhibitor of PP1 being involved in the signaling cascade...
July 5, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/28676373/middle-age-exacerbates-acute-respiratory-distress-syndrome-in-a-double-hit-murine-model
#5
Guillaume Voiriot, Damien Contou, Jeanne Tran Van Nhieu, Valerie Amsellem, Elisabeth Marcos, Mehdi Latiri, Serge Adnot, Bernard Maitre, Armand Mekontso Dessap
RATIONALE: In a recent systematic review, aging has been identified as the only factor independently associated with mortality during human acute respiratory distress syndrome (ARDS). We explored this age-dependent severity in a clinically relevant double hit murine ARDS model. METHODS: Young adult (Y, 10-12weeks) and middle-old (O, 12-13months) male C57BL6 mice underwent an aspiration of Escherichia coli lipopolysaccharide (LPS) or control saline vehicle. Twenty hours later, four groups of mice were sacrificed [Y(control), O(control), Y(LPS) and O(LPS)]...
July 1, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28664496/efficient-model-calibration-method-based-on-phase-experiments-for-anaerobic-anoxic-nitrifying-a2n-two-sludge-process
#6
Hongliang Dai, Wenliang Chen, Zheqin Dai, Xiang Li, Xiwu Lu
A systematic calibration and validation procedure for the complex mechanistic modeling of anaerobic-anoxic/nitrifying (A2N) two-sludge system is needed. An efficient method based on phase experiments, sensitivity analysis, and genetic algorithm is proposed here for model calibration. Phase experiments (anaerobic phosphorus release, aerobic nitrification, and anoxic denitrifying phosphate accumulation) in an A2N sequencing batch reactor (SBR) were performed to reflect the process conditions accurately and improve the model calibration efficiency...
June 30, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28662370/early-exposure-to-recommended-calorie-delivery-in-the-intensive-care-unit-is-associated-with-increased-mortality-in-patients-with-acute-respiratory-distress-syndrome
#7
Sarah J Peterson, Omar B Lateef, Sally Freels, Liam McKeever, Giamila Fantuzzi, Carol A Braunschweig
BACKGROUND: The Intensive Nutrition in Acute Lung Injury: Clinical Trial (INTACT), designed to evaluate outcomes of calorie delivery from acute respiratory distress syndrome (ARDS) diagnosis through hospital discharge, was stopped due to higher mortality in the intervention group. Post hoc analysis found timing and dose of calorie delivery influenced mortality. The objective of this retrospective cohort study was to determine if early vs late calorie exposure changed the hazard of death among a larger sample of patients with ARDS...
June 1, 2017: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28655914/igf1r-deficiency-attenuates-acute-inflammatory-response-in-a-bleomycin-induced-lung-injury-mouse-model
#8
Sergio Piñeiro-Hermida, Icíar P López, Elvira Alfaro-Arnedo, Raquel Torrens, María Iñiguez, Lydia Alvarez-Erviti, Carlos Ruíz-Martínez, José G Pichel
IGF1R (Insulin-like Growth Factor 1 Receptor) is a tyrosine kinase with pleiotropic cellular functions. IGF activity maintains human lung homeostasis and is implicated in pulmonary diseases such as cancer, ARDS, COPD, asthma and fibrosis. Here we report that lung transcriptome analysis in mice with a postnatally-induced Igf1r gene deletion showed differentially expressed genes with potentially protective roles related to epigenetics, redox and oxidative stress. After bleomycin-induced lung injury, IGF1R-deficient mice demonstrated improved survival within a week...
June 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28638955/lipopolysaccharide-induced-ccn1-production-enhances-interleukin-6-secretion-in-bronchial-epithelial-cells
#9
Lin Shi, Nian Dong, Dongxiang Ji, Xiaomin Huang, Zhaojian Ying, Xiangdong Wang, Chengshui Chen
Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a clinical complication caused by primary or secondary lung injury, as well as by systemic inflammation. Researches regarding molecular pathophysiology of ALI/ARDS are immerging with an ultimate aim towards developing prognostic molecular biomarkers and molecule-based therapy. However, the molecular mechanisms concerning ALI/ARDS are still not completely understood. The purpose of the present study was to identify a crucial role of CCN1 in inflammatory microenvironment during ALI/ARDS and focus on a potential communication between CCN1 and interleukin-6 (IL-6) in the airway epithelial cells...
June 21, 2017: Cell Biology and Toxicology
https://www.readbyqxmd.com/read/28634422/lipopolysaccharide-binding-protein-downregulates-fractalkine-through-activation-of-p38-mapk-and-nf-%C3%AE%C2%BAb
#10
Xia Huang, Yi Zeng, Yujie Jiang, Yueqiu Qin, Weigui Luo, Shulin Xiang, Suren R Sooranna, Liao Pinhu
BACKGROUND: LBP and fractalkine are known to be involved in the pathogenesis of ARDS. This study investigated the relationship between LBP and fractalkine in LPS-induced A549 cells and rat lung tissue in an ARDS rat model. METHODS: A549 cells were transfected with LBP or LBP shRNA plasmid DNA or pretreated with SB203580 or SC-514 following LPS treatment. An ARDS rat model was established using LPS with or without LBPK95A, SB203580, or SC-514 treatment. RT-PCR, western blotting, ELISA, immunofluorescence, coimmunoprecipitation, and immunohistochemical staining were used to study the expression of fractalkine and LBP and p38 MAPK and p65 NF-κB activities...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28634220/tidal-changes-on-ct-and-progression-of-ards
#11
Maurizio Cereda, Yi Xin, Hooman Hamedani, Giacomo Bellani, Stephen Kadlecek, Justin Clapp, Luca Guerra, Natalie Meeder, Jennia Rajaei, Nicholas J Tustison, James C Gee, Brian P Kavanagh, Rahim R Rizi
BACKGROUND: Uncertain prediction of outcome in acute respiratory distress syndrome (ARDS) impedes individual patient management and clinical trial design. OBJECTIVES: To develop a radiological metric of injurious inflation derived from matched inspiratory and expiratory CT scans, calibrate it in a model of experimental lung injury, and test it in patients with ARDS. METHODS: 73 anaesthetised rats (acid aspiration model) were ventilated (protective or non-protective) for up to 4 hours to generate a spectrum of lung injury...
June 20, 2017: Thorax
https://www.readbyqxmd.com/read/28631361/optimal-right-heart-filling-pressure-in-acute-respiratory-distress-syndrome-determined-by-strain-echocardiography
#12
Romel Garcia-Montilla, Faryal Imam, Mi Miao, Kathryn Stinson, Akram Khan, Stephen Heitner
INTRODUCTION: Right ventricular (RV) systolic dysfunction is common in acute respiratory distress syndrome (ARDS). While preload optimization is crucial in its management, dynamic fluid responsiveness indices lack reliability, and there is no consensus on target central venous pressure (CVP). We analyzed the utility of RV free wall longitudinal strain (RVFWS) in the estimation of optimal RV filling pressure in ARDS. METHODS: A retrospective cross-sectional analysis of clinical data and echocardiograms of patients with ARDS was performed...
June 2017: Echocardiography
https://www.readbyqxmd.com/read/28611227/lung-injury-etiology-and-other-factors-influencing-the-relationship-between-dead-space-fraction-and-mortality-in-ards
#13
Richard H Kallet, Hanjing Zhuo, Kelly Ho, Michael S Lipnick, Antonio Gomez, Michael A Matthay
BACKGROUND: In ARDS, elevated pulmonary dead-space fraction (VD/VT) is a particularly strong indicator of mortality risk. Whether the magnitude of VD/VT is modified by the underlying etiology of ARDS and whether this influences the strength of its association with mortality remains unknown. We sought to elucidate the impact of ARDS etiology on VD/VT and also to determine whether ARDS severity, as classified by the Berlin definition, has correspondence with changes in VD/VT. METHODS: This single-center, retrospective, observational study (2010-2016) measured VD/VT in 685 subjects with ARDS as part of clinical management with lung-protective ventilation...
June 13, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28604782/viral-genetic-variation-accounts-for-a-third-of-variability-in-hiv-1-set-point-viral-load-in-europe
#14
François Blanquart, Chris Wymant, Marion Cornelissen, Astrid Gall, Margreet Bakker, Daniela Bezemer, Matthew Hall, Mariska Hillebregt, Swee Hoe Ong, Jan Albert, Norbert Bannert, Jacques Fellay, Katrien Fransen, Annabelle J Gourlay, M Kate Grabowski, Barbara Gunsenheimer-Bartmeyer, Huldrych F Günthard, Pia Kivelä, Roger Kouyos, Oliver Laeyendecker, Kirsi Liitsola, Laurence Meyer, Kholoud Porter, Matti Ristola, Ard van Sighem, Guido Vanham, Ben Berkhout, Paul Kellam, Peter Reiss, Christophe Fraser
HIV-1 set-point viral load-the approximately stable value of viraemia in the first years of chronic infection-is a strong predictor of clinical outcome and is highly variable across infected individuals. To better understand HIV-1 pathogenesis and the evolution of the viral population, we must quantify the heritability of set-point viral load, which is the fraction of variation in this phenotype attributable to viral genetic variation. However, current estimates of heritability vary widely, from 6% to 59%. Here we used a dataset of 2,028 seroconverters infected between 1985 and 2013 from 5 European countries (Belgium, Switzerland, France, the Netherlands and the United Kingdom) and estimated the heritability of set-point viral load at 31% (CI 15%-43%)...
June 2017: PLoS Biology
https://www.readbyqxmd.com/read/28598224/mesenchymal-stromal-cells-modulate-macrophages-in-clinically-relevant-lung-injury-models-by-extracellular-vesicle-mitochondrial-transfer
#15
Thomas J Morrison, Megan V Jackson, Erin K Cunningham, Adrien Kissenpfennig, Daniel F McAuley, Cecilia M O'Kane, Anna D Krasnodembskaya
RATIONALE: Acute Respiratory Distress Syndrome (ARDS) remains a major cause of respiratory failure in critically ill patients. Mesenchymal Stromal Cells (MSCs) are a promising candidate for a cell based therapy. However, the mechanisms of MSCs effects in ARDS are not well understood. Here we focused on the paracrine effect of MSCs on macrophage polarization and the role of extracellular vesicle (EV)-mediated mitochondrial transfer. OBJECTIVES: To determine the effects of human MSCs on macrophage function in the ARDS environment and to elucidate the mechanisms of these effects...
June 9, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28593401/external-validation-of-a-biomarker-and-clinical-prediction-model-for-hospital-mortality-in-acute-respiratory-distress-syndrome
#16
Zhiguo Zhao, Nancy Wickersham, Kirsten N Kangelaris, Addison K May, Gordon R Bernard, Michael A Matthay, Carolyn S Calfee, Tatsuki Koyama, Lorraine B Ware
PURPOSE: Mortality prediction in ARDS is important for prognostication and risk stratification. However, no prediction models have been independently validated. A combination of two biomarkers with age and APACHE III was superior in predicting mortality in the NHLBI ARDSNet ALVEOLI trial. We validated this prediction tool in two clinical trials and an observational cohort. METHODS: The validation cohorts included 849 patients from the NHLBI ARDSNet Fluid and Catheter Treatment Trial (FACTT), 144 patients from a clinical trial of sivelestat for ARDS (STRIVE), and 545 ARDS patients from the VALID observational cohort study...
August 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28586887/association-of-gestational-weight-gain-with-maternal-and-infant-outcomes-a-systematic-review-and-meta-analysis
#17
REVIEW
Rebecca F Goldstein, Sally K Abell, Sanjeeva Ranasinha, Marie Misso, Jacqueline A Boyle, Mary Helen Black, Nan Li, Gang Hu, Francesco Corrado, Line Rode, Young Ju Kim, Margaretha Haugen, Won O Song, Min Hyoung Kim, Annick Bogaerts, Roland Devlieger, Judith H Chung, Helena J Teede
Importance: Body mass index (BMI) and gestational weight gain are increasing globally. In 2009, the Institute of Medicine (IOM) provided specific recommendations regarding the ideal gestational weight gain. However, the association between gestational weight gain consistent with theIOM guidelines and pregnancy outcomes is unclear. Objective: To perform a systematic review, meta-analysis, and metaregression to evaluate associations between gestational weight gain above or below the IOM guidelines (gain of 12...
June 6, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28570160/acute-respiratory-distress-syndrome-and-diffuse-alveolar-damage-new-insights-on-a-complex-relationship
#18
Pablo Cardinal-Fernández, José A Lorente, Aída Ballén-Barragán, Gustavo Matute-Bello
Acute respiratory distress syndrome (ARDS) is a major clinical problem with high morbidity and mortality. Diffuse alveolar damage (DAD) is considered the histological hallmark for the acute phase of ARDS. DAD is characterized by an acute phase with edema, hyaline membranes, and inflammation, followed by an organizing phase with alveolar septal fibrosis and type II pneumocyte hyperplasia. Given the difficulties in obtaining a biopsy in patients with ARDS, the presence of DAD is not required to make the diagnosis...
June 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28562480/indinavir-plus-methylprednisolone-ameliorates-experimental-acute-lung-injury-in-vitro-and-in-vivo
#19
Yunxia Ji, Guanghua Zhang, Haibo Zhu, Defang Li, Wanglin Jiang
BACKGROUND: An abnormal HMGB1 activation plays a key role in the pathogenesis of ALI. METHODS: In this study, the effects of Indinavir plus Methylprednisolone on the LPS-mediated activation in HPMECs, on the injury of AT I in vitro, and on rats with LPS-induced two-hit model with or without Methylprednisolone were investigated. RESULTS: Indinavir treatment resulted in a reduction of HMGB1, its receptor TLR-4, and HMGB1's downstream p-NF-κB, attenuating a decrease of VE-cadherin in LPS stimulated HPMECs...
May 29, 2017: Shock
https://www.readbyqxmd.com/read/28561802/nanofluid-types-their-synthesis-properties-and-incorporation-in-direct-solar-thermal-collectors-a-review
#20
REVIEW
Wisut Chamsa-Ard, Sridevi Brundavanam, Chun Che Fung, Derek Fawcett, Gerrard Poinern
The global demand for energy is increasing and the detrimental consequences of rising greenhouse gas emissions, global warming and environmental degradation present major challenges. Solar energy offers a clean and viable renewable energy source with the potential to alleviate the detrimental consequences normally associated with fossil fuel-based energy generation. However, there are two inherent problems associated with conventional solar thermal energy conversion systems. The first involves low thermal conductivity values of heat transfer fluids, and the second involves the poor optical properties of many absorbers and their coating...
May 31, 2017: Nanomaterials
keyword
keyword
86044
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"