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https://www.readbyqxmd.com/read/29627883/platelet-transfusion-increases-risk-for-acute-respiratory-distress-syndrome-in-non-massively-transfused-blunt-trauma-patients
#1
George Kasotakis, Nichole Starr, Erek Nelson, Bedabrata Sarkar, Peter Ashley Burke, Daniel George Remick, Ronald Gary Tompkins
PURPOSE: While damage control resuscitation is known to confer a survival advantage in severely injured patients, high-ratio blood component therapy should be initiated only in carefully selected trauma patients, due to the morbidity associated with blood product use. With this project, we aim to identify the effect of platelet transfusion in non-massively transfused bluntly injured patients. METHODS: The Glue Grant database was retrospectively queried and severely injured blunt trauma patients who underwent non-massive transfusion were identified...
April 7, 2018: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/29626893/multi-scale-coarse-graining-for-the-study-of-assembly-pathways-in-dna-brick-self-assembly
#2
Pedro Fonseca, Flavio Romano, John S Schreck, Thomas E Ouldridge, Jonathan P K Doye, Ard A Louis
Inspired by recent successes using single-stranded DNA tiles to produce complex structures, we develop a two-step coarse-graining approach that uses detailed thermodynamic calculations with oxDNA, a nucleotide-based model of DNA, to parametrize a coarser kinetic model that can reach the time and length scales needed to study the assembly mechanisms of these structures. We test the model by performing a detailed study of the assembly pathways for a two-dimensional target structure made up of 334 unique strands each of which are 42 nucleotides long...
April 7, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29622695/administration-of-mesenchymal-stem-cells-during-ecmo-results-in-a-rapid-decline-in-oxygenator-performance
#3
Jonathan Edward Millar, Viktor von Bahr, Maximillian V Malfertheiner, Katrina K Ki, Meredith A Redd, Nicole Bartnikowski, Jacky Y Suen, Danny Francis McAuley, John F Fraser
Mesenchymal stem cells (MSCs) have attracted attention as a potential therapy for Acute Respiratory Distress Syndrome (ARDS). At the same time, the use of extracorporeal membrane oxygenation (ECMO) has increased among patients with severe ARDS. To date, early clinical trials of MSCs in ARDS have excluded patients supported by ECMO. Here we provide evidence from an ex-vivo model of ECMO to suggest that the intravascular administration of MSCs during ECMO may adversely impact the function of a membrane oxygenator...
April 5, 2018: Thorax
https://www.readbyqxmd.com/read/29609458/kinetics-of-first-row-transition-metal-cations-v-fe-co-with-ocs-at-thermal-energies
#4
Brendan C Sweeny, Shaun G Ard, Nicholas S Shuman, Albert A Viggiano
The temperature-dependent kinetics for reactions of V+ , Fe+ , and Co+ with OCS are measured using a selected ion flow tube apparatus heated to 300 - 600 K. All three reactions proceed solely by C-S activation at thermal energies, resulting in metal sulfide cation formation. Previously calculated reaction pathways were employed to inform statistical modelling of these reactions for comparison to the data. As surmised previously, all three reactions at thermal energies require spin crossing, with the Fe+ reaction crossing once circumventing a prohibitive transition state, before crossing again to form ground state products...
April 2, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29608956/detection-and-validation-of-est-ssr-markers-associated-with-sugar-related-traits-in-sugarcane-using-linkage-and-association-mapping
#5
Kittipat Ukoskit, Ganlayarat Posudsavang, Nattapat Pongsiripat, Prasert Chatwachirawong, Peeraya Klomsa-Ard, Patthinun Poomipant, Somvong Tragoonrung
Sugar-related traits are of great importance in sugarcane breeding. In the present study, quantitative trait loci (QTL) mapping validated with association mapping was used to identify expressed sequence tag-simple sequence repeats (EST-SSRs) associated with sugar-related traits. For linkage mapping, 524 EST-SSRs, 241 Amplified Fragment Length Polymorphisms, and 10 genomic SSR markers were mapped using 283 F1 progenies derived from an interspecific cross. Six regions were identified using Multiple QTL Mapping, and 14 unlinked markers using single marker analysis...
March 31, 2018: Genomics
https://www.readbyqxmd.com/read/29606872/porous-se-sio-2-nanocomposites-protect-the-femoral-head-from-methylprednisolone-induced-osteonecrosis
#6
Guoying Deng, Chenyun Dai, Jinyuan Chen, Anqi Ji, Jingpeng Zhao, Yue Zhai, Yingjie Kang, Xijian Liu, Yin Wang, Qiugen Wang
Background: Methylprednisolone (MPS) is an important drug used in therapy of many diseases. However, osteonecrosis of the femoral head is a serious damage in the MPS treatment. Thus, it is imperative to develop new drugs to prevent the serious side effect of MPS. Methods: The potential interferences Se@SiO2 nanocomposites may have to the therapeutic effect of methylprednisolone (MPS) were evaluated by classical therapeutic effect index of acute respiratory distress syndrome (ARDS), such as wet-to-dry weight ratio, inflammatory factors IL-1β and TNF-α...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29600057/neutrophil-to-lymphocyte-ratio-as-a-prognostic-marker-in-acute-respiratory-distress-syndrome-patients-a-retrospective-study
#7
Ying Wang, Mohan Ju, Cuicui Chen, Dong Yang, Dongni Hou, Xinjun Tang, Xiaodan Zhu, Donghui Zhang, Lilin Wang, Shimeng Ji, Jinjun Jiang, Yuanlin Song
Background: Acute respiratory distress syndrome (ARDS) is the leading cause of high mortality in intensive care units (ICUs) worldwide. An effective marker for prognosis in ARDS is particularly important given the absence of effective treatment strategies aside from small tidal volume ventilation. Previous studies identified an association between the neutrophil-to-lymphocyte ratio (NLR) and prognosis in critical patients. In this study, we explored the prognostic and predictive value of the NLR in ARDS patients...
January 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29595879/capturing-the-multifactorial-nature-of-ards-two-hit-approach-to-model-murine-acute-lung-injury
#8
Sandra Hoegl, Nana Burns, Martín Angulo, Daniel Francis, Christopher M Osborne, Tingting W Mills, Michael R Blackburn, Holger K Eltzschig, Christine U Vohwinkel
Severe acute respiratory distress syndrome (ARDS) presents typically with an initializing event, followed by the need for mechanical ventilation. Most animal models of ALI are limited by the fact that they focus on a singular cause of acute lung injury (ALI) and therefore fail to mimic the complex, multifactorial pathobiology of ARDS. To better capture this scenario, we provide a comprehensive characterization of models of ALI combining two injuries: intra tracheal (i.t.) instillation of LPS or hypochloric acid (HCl) followed by ventilator-induced lung injury (VILI)...
March 2018: Physiological Reports
https://www.readbyqxmd.com/read/29590136/alveolar-leak-develops-by-a-rich-get-richer-process-in-ventilator-induced-lung-injury
#9
Katharine L Hamlington, Jason H T Bates, Gregory S Roy, Adele J Julianelle, Chantel Charlebois, Bela Suki, Bradford J Smith
Acute respiratory distress syndrome (ARDS) is a life-threatening condition for which there are currently no medical therapies other than supportive care involving the application of mechanical ventilation. However, mechanical ventilation itself can worsen ARDS by damaging the alveolocapillary barrier in the lungs. This allows plasma-derived fluid and proteins to leak into the airspaces of the lung where they interfere with the functioning of pulmonary surfactant, which increases the stresses of mechanical ventilation and worsens lung injury...
2018: PloS One
https://www.readbyqxmd.com/read/29565500/expression-of-nrf2-keap1-are-signal-pathway-in-traumatic-lung-injury-and-functional-study
#10
L-Y Hu, J-B Cui, X-M Xu, Z-H Huang, H-T Jiao
OBJECTIVE: Traumatic lung injury (TLI) can cause inflammation and oxidative stress, or even leads to acute respiratory distress syndrome (ARDS) and death. Nuclear factor erythroid-2 related factor 2 (Nrf2)-Kelch-like ECH-associated protein 1 (Keap1)-antioxidant response element (ARE) signal pathway participates in disease occurrence and progression via regulating inflammatory and oxidative stress response, but with its expression and functional roles in TLI largely unknown. MATERIALS AND METHODS: Wistar rats were randomly divided into control group, TLI group by crushing method, and Nrf2 activation group which received Nrf2 specific agonist sulforaphane 30 min before TLI treatment...
March 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29555594/ultrastructural-alteration-of-pulmonary-capillary-endothelial-glycocalyx-during-endotoxemia
#11
Risa Inagawa, Hideshi Okada, Genzou Takemura, Kodai Suzuki, Chihiro Takada, Hirohisa Yano, Yoshiaki Ando, Takahiro Usui, Yasuaki Hotta, Nagisa Miyazaki, Akiko Tsujimoto, Ryogen Zaikokuji, Atsumu Matsumoto, Tomonori Kawaguchi, Tomoaki Doi, Takahiro Yoshida, Shozo Yoshida, Keisuke Kumada, Hiroaki Ushikoshi, Izumi Toyoda, Shinji Ogura
BACKGROUND: The most recent diagnostic criteria for sepsis includes organ failure. Microvascular endothelial injury is thought to lead to the multiple organ failure seen in sepsis, although the precise mechanism is still controversial. Acute respiratory distress syndrome (ARDS) is the primary complication during the sequential development of multiple organ dysfunction in sepsis, and endothelial injury is deeply involved. Sugar-protein glycocalyx coats all healthy vascular endothelium, and its disruption is one factor thought to contribute to microvascular endothelial dysfunction during sepsis...
March 16, 2018: Chest
https://www.readbyqxmd.com/read/29554114/synthesis-of-phosphatidylcholine-in-rats-with-oleic-acid-induced-pulmonary-edema-and-effect-of-exogenous-pulmonary-surfactant-on-its-de-novo-synthesis
#12
Xiwen Gao, Peiyu Qian, Dong Cen, Weijun Hong, Qing Peng, Min Xue
In mammals, oleic acid (OA) induces pulmonary edema (PE), which can initiate acute lung injury (ALI) and lead to acute respiratory distress syndrome (ARDS). Pulmonary surfactant (PS) plays a key role in a broad range of treatments for ARDS. The aim of the present investigation was to assess changes in the synthesis of phosphatidylcholine (PC) from choline and determine the effect of exogenous PS on its de novo synthesis in rats with OA-induced PE. Experimental rats were randomized into three groups, including a control group, OA-induced PE group, and OA-induced group treated with exogenous PS (OA-PS)...
2018: PloS One
https://www.readbyqxmd.com/read/29553813/amicus-or-adversary-revisited-platelets-in-acute-lung-injury-acute-respiratory-distress-syndrome
#13
Elizabeth A Middleton, Matthew T Rondina, Hansjorg Schwertz, Guy A Zimmerman
Platelets are essential cellular effectors of hemostasis and contribute to disease as circulating effectors of pathologic thrombosis. These are their most widely known biologic activities. Nevertheless, recent observations demonstrate that platelets have a much more intricate repertoire beyond these traditional functions, and are specialized for contributions to vascular barrier integrity, organ repair, antimicrobial host defense, inflammation, and activities across the immune continuum. Paradoxically, some of these newly-discovered activities of platelets appear to contribute to tissue injury based on clinical investigations and animal models of disease...
March 19, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29549747/the-impact-of-organ-dysfunctions-on-mortality-in-patients-with-severe-sepsis-a-multicenter-prospective-observational-study
#14
Daisuke Kudo, Shigeki Kushimoto, Noriko Miyagawa, Tetsuya Sato, Masatsugu Hasegawa, Fumihito Ito, Sathoshi Yamanouchi, Hiroyuki Honda, Kohkichi Andoh, Hajime Furukawa, Yasuo Yamada, Yuta Tsujimoto, Manabu Okuyama
PURPOSE: Disseminated intravascular coagulations (DIC), acute respiratory distress syndrome (ARDS), and acute kidney injury (AKI) are major organ dysfunctions that occur in patients with sepsis. This study aimed to elucidate the impact of these organ dysfunctions on mortality in patients with severe sepsis. MATERIAL AND METHODS: A prospective observational study was performed in 10 ICUs to obtain data from patients with severe sepsis. Multivariate analyses to examine in-hospital mortality were performed...
March 7, 2018: Journal of Critical Care
https://www.readbyqxmd.com/read/29545858/effect-of-tlr4-myd88-signaling-pathway-on-sepsis-associated-acute-respiratory-distress-syndrome-in-rats-via-regulation-of-macrophage-activation-and-inflammatory-response
#15
Shujun Zhou, Gui Wang, Wenbin Zhang
The present study aimed to investigate the effects of the Toll-like receptor (TLR)4/myeloid differentiation primary response (MyD)88 signaling pathway on sepsis-associated acute respiratory distress syndrome (ARDS) in rats, and the involvement of macrophage activation and the inflammatory response. A total of 36 specific pathogen-free male Sprague-Dawley rats were selected to establish the rat model of sepsis-associated ARDS using cecal ligation and puncture (CLP). Rats were assigned into the Ab (anti-TLR4 monoclonal antibody)-CLP, CLP and Sham groups...
April 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29529495/in-silico-investigation-of-the-molecular-effects-caused-by-r123h-variant-in-secretory-phospholipase-a2-iia-associated-with-ards
#16
Benedetta Righino, Angelo Minucci, Davide Pirolli, Ettore Capoluongo, Giorgio Conti, Daniele De Luca, Maria Cristina De Rosa
Phospholipase A2-IIA catalyzes the hydrolysis of the sn-2 ester of glycerophospholipids. A rare c.428G > A (p.Arg143His) variant in PLA2G2A gene was found in two infants affected by acute respiratory distress syndrome (ARDS) by whole coding region and exon/intron boundaries sequencing. To obtain insights into the possible molecular effects of the rare R123H mutation in secretory PLA2-IIA (sPLA2-IIA), molecular modelling, molecular dynamics (MD) using principal component analysis (PCA) and continuum electrostatic calculations were conducted on the crystal structure of the wild type protein and on a generated model structure of the R123H mutant...
March 6, 2018: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29522858/glucocorticoid-receptor-gene-expression-in-a-clp-induced-ards-like-rat-model-treated-with-dexamethasone-and-metyrapone
#17
Roseli Soncini, Joseana Vieira, Ana Carolina Ramos Lopes, Silvia Graciela Ruginsk, Erika K Incerpi, Angel Roberto Barchuk
Glucocorticoids (GCs) are used for acute respiratory distress syndrome (ARDS) to improve or prevent lung injury. The mechanisms underlying the effects of GCs involve inadequate GC-receptor (GR)-mediated downregulation of pro-inflammatory factors despite elevated levels of cortisol. Within this context, knowledge of the transcriptional pattern of the GR gene in response to variations in physiological parameters may shed light on this issue. We addressed this problem by measuring plasmatic corticosterone (CCT) levels and assessing GR expression at transcript and protein levels in rats with caecal ligation and puncture (CLP)-induced ARDS-like syndrome treated with dexamethasone and metyrapone...
March 6, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29521174/express-difficulties-in-modelling-ards-2017-grover-conference-series
#18
Stefan Uhlig, Wolfgang Michael Kuebler
No abstract text is available yet for this article.
January 1, 2018: Pulmonary Circulation
https://www.readbyqxmd.com/read/29519276/-effects-of-acute-respiratory-distress-syndrome-induced-by-endotoxin-on-the-right-ventricular-function-in-rats
#19
Shaolei Ma, Yujie Wang, Xiangrong Zuo, Jing Yao, Quan Cao
OBJECTIVE: To explore the effect of acute respiratory distress syndrome (ARDS) induced by endotoxin on the right ventricular function in rats. METHODS: Sixty male Sprague-Dawley (SD) rats were randomly divided into normal saline (NS) control group and lipopolysaccharide (LPS) model group with 30 rats in each group. The rat model of ARDS was reproduced by intratracheal instillation of LPS 10 mg/kg after tracheotomy, and the rats in NS control group was intratracheally given the same volume of NS instead of LPS...
March 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29519254/the-preventive-effect-of-antiplatelet-therapy-in-acute-respiratory-distress-syndrome-a-meta-analysis
#20
Yingqin Wang, Ming Zhong, Zhichao Wang, Jieqiong Song, Wei Wu, Duming Zhu
BACKGROUND: Acute respiratory distress syndrome (ARDS) is a life-threatening condition with high mortality that imposes a serious medical burden. Antiplatelet therapy is a potential strategy for preventing ARDS in patients with a high risk of developing this condition. A meta-analysis was performed to investigate whether antiplatelet therapy could reduce the incidence of newly developed ARDS and its associated mortality in high-risk patients. METHODS: The Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, Embase, Medline, and the Web of Science were searched for published studies from inception to 26 October 2017...
March 8, 2018: Critical Care: the Official Journal of the Critical Care Forum
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