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https://www.readbyqxmd.com/read/29212183/role-of-il-17-in-lps-induced-acute-lung-injury-an-in-vivo-study
#1
Qi Ding, Gao-Qin Liu, Yuan-Yuan Zeng, Jian-Jie Zhu, Ze-Yi Liu, Xueguang Zhang, Jian-An Huang
To assess the clinical significance of IL-17 in patients with sepsis-induced acute respiratory distress syndrome (ARDS) and to investigate the effects of IL-17 blocking in a mouse model of acute lung injury (ALI). Significantly increased IL-17 level was found in patients with sepsis-related ARDS compared to healthy controls, whereas significantly increased plasma IL-17 level was also observed in non-survivors compared to that in survivors. According to the data from the mouse ALI model, we found significantly increased IL-17 level in lung tissue lysates, mouse bronchoalveolar lavage fluid (mBALF) and plasma at 6, 12 and 24 h after ALI...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29206762/soluble-epoxide-hydrolase-plays-a-vital-role-in-angiotensin-ii-induced-lung-injury-in-mice
#2
Wei Tao, Ping-Song Li, Gang Xu, Yi Luo, Yu-Sheng Shu, Yong-Zhong Tao, Liu-Qing Yang
BACKGROUND: Angiotensin II plays a vital role in the pathogenesis of acute respiratory distress syndrome (ARDS). However, its mechanism is not well defined. Angiotensin II up-regulates the expression of soluble epoxide hydrolase (sEH; Ephx2). sEH is suggested as a potential pharmacologic target for ARDS. The present study investigates whether the sEH is involved in the angiotensin II triggered pulmonary inflammation and edema using an angiotensin II-induced lung injury animal model. METHODS: Lung injury was induced by angiotensin II intratracheally instillation in wild-type or Ephx2 deficient mice...
December 4, 2017: Shock
https://www.readbyqxmd.com/read/29202212/nebulized-heparin-attenuates-pulmonary-coagulopathy-and-inflammation-through-alveolar-macrophages-in-a-rat-model-of-acute-lung-injury
#3
Laura Chimenti, Marta Camprubí-Rimblas, Raquel Guillamat-Prats, Maria Nieves Gomez, Jessica Tijero, Lluis Blanch, Antonio Artigas
Objective Alveolar macrophages play a key role in the development and resolution of acute respiratory distress syndrome (ARDS), modulating the inflammatory response and the coagulation cascade in lungs. Anti-coagulants may be helpful in the treatment of ARDS. This study investigated the effects of nebulized heparin on the role of alveolar macrophages in limiting lung coagulation and inflammatory response in an animal model of acute lung injury (ALI). Methods Rats were randomized to four experimental groups...
November 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29200203/mir-200b-c-attenuates-lipopolysaccharide-induced-early-pulmonary-fibrosis-by-targeting-zeb1-2-via-p38-mapk-and-tgf-%C3%AE-smad3-signaling-pathways
#4
Yongmei Cao, Yujing Liu, Feng Ping, Lyu Yi, Zhen Zeng, Yingchuan Li
Pulmonary fibrosis triggered during the early stage of acute respiratory distress syndrome (ARDS) contributes to poor prognosis in patients. However, whether microRNAs (miRNAs) can serve as therapeutic targets for early pulmonary fibrosis during ARDS is still largely unknown. In this study, we evaluated the effects and mechanisms of miR-200s and its targets ZEB1/2 in lung tissue. An early pulmonary fibrosis mouse model caused by ARDS was established via a lipopolysaccharide (LPS) three-hit regimen. Lentiviral packaged miR-200b/c cDNA or ZEB1/2 shRNA was intratracheally administered into the lungs of C57BL/6 mice 1 day before an LPS injection was administered...
December 4, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/29193386/on-structure-and-reaction-mechanism-of-human-acireductone-dioxygenase
#5
Anna Maria Miłaczewska, Ewa Kot, José A Amaya, Thomas M Makris, Marcin Zając, Józef Korecki, Aleksandr Chumakov, Bartosz Trzewik, Sylwia Kędracka-Krok, Władek Minor, Maksymilian Chruszcz, Tomasz Maciej Borowski
Acireductone dioxygenase (ARD) is an intriguing enzyme from the methionine salvage pathway capable of catalyzing two different oxidation reactions with the same substrate, depending on the type of the metal ion in the active site. To date, the structural information regarding ARD-acireductone complex is limited and the reaction mechanisms are still under debate. In this contribution we report results of joint experimental and computational studies undertaken to advance our knowledge about ARD. We have determined a structure of ARD from Homo sapiens with selenomethionine...
November 28, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29179596/celastrol-attenuates-impairments-associated-with-lipopolysaccharide-induced-acute-respiratory-distress-syndrome-ards-in-rats
#6
Yongjun Wei, Yu Wang
Celastrol, a constituent from a traditional Chinese medicinal herb belonging to the family Celastraceae, has been shown to impart anti-inflammatory properties, in part, by inhibiting NF-κB activity and related induction of pro-inflammatory cytokine formation/release. The present study investigated the effects of celastrol in an animal model of acute respiratory distress syndrome (ARDS) induced by intratracheal administration of lipopolysaccharides (LPSs). Celastrol pre-treatment groups received celastrol by intraperitoneal injection on seven consecutive days before LPS treatment...
December 2017: Journal of Immunotoxicology
https://www.readbyqxmd.com/read/29179210/enacs-as-both-effectors-and-regulators-of-mirnas-in-lung-epithelial-development-and-regeneration
#7
Yan Ding, Runzhen Zhao, Xiaoli Zhao, Michael A Matthay, Hong-Guang Nie, Hong-Long Ji
Epithelial sodium channels (ENaC) play an important role in re-absorbing excessive luminal fluid by building up an osmotic Na+ gradient across the tight epithelium in the airway, the lung, the kidney, and the colon. The ENaC is a major pathway for retention of salt in kidney too. MicroRNAs (miRs), a group of non-coding RNAs that regulate gene expression at the post-transcriptional level, have emerged as a novel class of regulators for ENaC. Given the ENaC pathway is crucial for maintaining fluid homeostasis in the lung and the kidney and other cavities, we summarized the cross-talk between ENaC and miRs and recapitulated the underlying regulatory factors, including aldosterone, transforming growth factor-β1, and vascular endothelial growth factor-A in the lung and other epithelial tissues/organs...
November 27, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29176329/inflammatory-processes-during-acute-respiratory-distress-syndrome-a-complex-system
#8
Lucy K Reiss, Andreas Schuppert, Stefan Uhlig
PURPOSE OF REVIEW: ARDS is a severe pulmonary disease characterized by inflammation. However, inflammation-directed therapies have yet failed to improve the outcome in ARDS patients. One of the reasons may be the underestimated complexity of inflammation. Here, we summarize recent insights into the complex interrelations between inflammatory circuits. RECENT FINDINGS: Gene expression analysis from animal models or from patients with ARDS, sepsis or trauma show an enormous number of differentially expressed genes with highly significant overlaps between the various conditions...
November 15, 2017: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/29175086/re-examining-permissive-hypercapnia-in-ards-a-narrative-review
#9
REVIEW
Tavish Barnes, Vasileios Zochios, Ken Parhar
Lung protective ventilation has become the cornerstone of management in patients with ARDS. A subset of patients are unable to tolerate lung protective ventilation without significant carbon dioxide elevation. In these patients permissive hypercapnia is used. Although thought to be benign, it is becoming increasingly evident that elevated carbon dioxide levels have significant physiological effects. In this narrative review, we highlight clinically relevant end organ effects in both animal models and clinical studies...
November 21, 2017: Chest
https://www.readbyqxmd.com/read/29174041/quasi-static-pulmonary-p-v-curves-of-patients-with-ards-part-i-characterization
#10
Mohsen Nabian, Uichiro Narusawa
Quasi-static, pulmonary pressure-volume (P-V) curves are combined with a respiratory system model to analyze characteristics of patients with acute respiratory distress syndrome (ARDS). It is shown that there exist distinct differences between healthy- and injured- respiratory system in the order of magnitudes of parameters of their P-V model equation. Four stages of ARDS (Early ARDS, Deep knee, Advanced ARDS and Baby lung) are defined quantitatively in terms of these parameters.
November 21, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29162066/effect-of-sivelestat-sodium-in-patients-with-acute-lung-injury-or-acute-respiratory-distress-syndrome-a-meta-analysis-of-randomized-controlled-trials
#11
Shenglan Pu, Daoxin Wang, Daishun Liu, Yan Zhao, Di Qi, Jing He, Guoqi Zhou
BACKGROUND: Sivelestat is widely used in treating acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), although the clinical efficacy of sivelestat remains controversial. This study aimed to evaluate the impact of sivelestat in patients with ALI/ARDS. METHODS: Electronic databases, PubMed, Embase, and the Cochrane Library, were searched to identify trials through April 2017. Randomized controlled trials (RCTs) were included irrespective of blinding or language that compared patients with and without sivelestat therapy in ALI/ARDS...
November 21, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29138874/using-il-6-concentrations-in-the-first-24%C3%A2-h-following-trauma-to-predict-immunological-complications-and-mortality-in-trauma-patients-a-meta-analysis
#12
REVIEW
Zhi Qiao, Weikang Wang, Luxu Yin, Peng Luo, Johannes Greven, Klemens Horst, Frank Hildebrand
PURPOSE: In previous studies, interleukin-6 (IL-6) has been shown to have a high predictive value for the development of complications and mortality after trauma; however, there is some uncertainty around these results. The aim of this meta-analysis was to assess the value of early IL-6 levels (within the first 24 h after trauma) for predicting post-traumatic complications [acute respiratory distress syndrome (ARDS), systemic inflammatory response syndrome (SIRS), sepsis, multiple organ failure (MOF), and multiple organ dysfunction syndrome (MODS)] and mortality...
November 14, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/29136027/expression-of-toll-like-receptors-tlrs-in-the-lungs-of-an-experimental-sepsis-mouse-model
#13
Anargyros Bakopoulos, Alkistis Kapelouzou, Diamantis I Tsilimigras, Michalis Katsimpoulas, Dimitrios Schizas, Chrysostomos Aravanis, Evaggelos Balafas, Manolis Mavroidis, Kitty Pavlakis, Anastasios Machairas, Theodore Liakakos
BACKGROUND: Sepsis is a condition characterized by high mortality rates and often accompanied by multiple-organ dysfunction. During sepsis, respiratory system may be affected and possibly result in acute respiratory distress syndrome (ARDS). Toll-like receptors (TLRs), as a first line defense against invading pathogens, seem to be highly expressed in septic states. Therefore, expression of TLRs in the lungs of a sepsis animal model could indicate the involvement of the respiratory system and appear as a severity index of the clinical course...
2017: PloS One
https://www.readbyqxmd.com/read/29124111/potential-implications-of-practice-effects-in-alzheimer-s-disease-prevention-trials
#14
Diane M Jacobs, M Colin Ard, David P Salmon, Douglas R Galasko, Mark W Bondi, Steven D Edland
Introduction: Practice effects (PEs) present a potential confound in clinical trials with cognitive outcomes. A single-blind placebo run-in design, with repeated cognitive outcome assessments before randomization to treatment, can minimize effects of practice on trial outcome. Methods: We investigated the potential implications of PEs in Alzheimer's disease prevention trials using placebo arm data from the Alzheimer's Disease Cooperative Study donepezil/vitamin E trial in mild cognitive impairment...
November 2017: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://www.readbyqxmd.com/read/29102631/edaravone-attenuates-lipopolysaccharide-induced-acute-respiratory-distress-syndrome-associated-early-pulmonary-fibrosis-via-inhibition-of-oxidative-stress-and-transforming-growth-factor-%C3%AE-1-smad3-signaling
#15
Xida Wang, Rongde Lai, Xiangfen Su, Guibin Chen, Zijing Liang
Pulmonary fibrosis is responsible for the both short-term and long-term outcomes in patients with acute respiratory distress syndrome (ARDS). There is still no effective cure to improve prognosis. The purpose of this study was to investigate whether edaravone, a free radical scavenger, have anti-fibrosis effects in the rat model of ARDS associated early pulmonary fibrosis by lipopolysaccharide (LPS) administration. Rats were subjected to intravenous injection of LPS, and edaravone was given intraperitoneally after LPS administration daily for 7 consecutive days...
November 1, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29101102/prevalence-of-knee-pain-radiographic-osteoarthritis-and-arthroplasty-in-retired-professional-footballers-compared-with-men-in-the-general-population-a-cross-sectional-study
#16
Gwen Sascha Fernandes, Sanjay Mukund Parekh, Jonathan Moses, Colin Fuller, Brigitte Scammell, Mark Edward Batt, Weiya Zhang, Michael Doherty
OBJECTIVES: To determine the prevalence of knee pain, radiographic knee osteoarthritis (RKOA), total knee replacement (TKR) and associated risk factors in male ex-professional footballers compared with men in the general population (comparison group). METHODS: 1207 male ex-footballers and 4085 men in the general population in the UK were assessed by postal questionnaire. Current knee pain was defined as pain in or around the knees on most days of the previous month...
November 3, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29100396/combination-therapy-of-human-umbilical-cord-mesenchymal-stem-cells-and-fty720-attenuates-acute-lung-injury-induced-by-lipopolysaccharide-in-a-murine-model
#17
Zili Zhang, Wenfei Li, Zhizhi Heng, Jing Zheng, Puyuan Li, Xin Yuan, Wenkai Niu, Changqing Bai, Huiying Liu
ALI/ARDS remain the main reason of morbidity and mortality in the critically ill. Studies have indicated that human umbilical cord mesenchymal stem cells (hUC-MSCs) can be useful in the treatment of ALI/ARDS. Sphingosine-1-phosphate (S1P) and its analog FTY720 significantly reduce lipopolysaccharide (LPS)-induced lung edema and inflammatory lung injury. This study aimed to assess the therapeutic effects of hUC-MSCs combined with FTY720 in an LPS-induced murine model of ALI. Eight-week-old female C57BL/6 mice were divided into a normal control group, an LPS group, an hUC-MSC group, an FTY720 group, and an hUC-MSCs+FTY720 group randomly...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29098546/silymarin-mitigates-lung-impairments-in-a-rat-model-of-acute-respiratory-distress-syndrome
#18
Zhongming Zhu, Gengyun Sun
Acute respiratory distress syndrome (ARDS) is a deadly disease and lacks effective treatments. Inflammation and oxidative stress play key roles in ARDS development. We aimed to evaluate the efficacy of pretreatment of silymarin, which has capacities of anti-inflammatory and anti-oxidative stress, in ARDS. We used lipopolysaccharide (LPS) to generate an ARDS rat model, which was pretreated with silymarin. Lung wet/dry ratio and broncho-alveolar lavage fluid (BALF) analyses were performed. Histological changes of the lungs were evaluated using hematoxylin and eosin staining...
November 2, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/29096634/prediction-of-high-airway-pressure-using-a-non-linear-autoregressive-model-of-pulmonary-mechanics
#19
Ruby Langdon, Paul D Docherty, Christoph Schranz, J Geoffrey Chase
BACKGROUND: For mechanically ventilated patients with acute respiratory distress syndrome (ARDS), suboptimal PEEP levels can cause ventilator induced lung injury (VILI). In particular, high PEEP and high peak inspiratory pressures (PIP) can cause over distension of alveoli that is associated with VILI. However, PEEP must also be sufficient to maintain recruitment in ARDS lungs. A lung model that accurately and precisely predicts the outcome of an increase in PEEP may allow dangerous high PIP to be avoided, and reduce the incidence of VILI...
November 2, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/29095932/metabolomics-based-predictive-biomarker-model-of-ards-a-systemic-measure-of-clinical-hypoxemia
#20
Neeraj Sinha, Akhila Viswan, Chandan Singh, Ratan Kumar Rai, Afzal Azim, Arvind Kumar Baronia
Despite advancements in ventilator technologies, lung supportive and rescue therapies, the outcome and prognostication in acute respiratory distress syndrome (ARDS) remains incremental and ambiguous. Metabolomics is a potential insightful measure to the diagnostic approaches practiced in critical disease settings. In our study patients diagnosed with mild and moderate/severe ARDS clinically governed by hypoxemic P/F ratio between 100-300 but with indistinct molecular phenotype were discriminated employing nuclear magnetic resonance (NMR) based metabolomics of mini bronchoalveolar lavage fluid (mBALF)...
2017: PloS One
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