Meghan S Vermillion, Nathan Saari, Mathieu Bray, Andrew M Nelson, Robert L Bullard, Karin Rudolph, Andrew P Gigliotti, Jeffrey Brendler, Jacob Jantzi, Philip J Kuehl, Jacob D McDonald, Mark E Burgert, Waylon Weber, Scott Sucoloski, David J Behm
As a regulator of alveolo-capillary barrier integrity, Transient Receptor Potential Vanilloid 4 (TRPV4) antagonism represents a promising strategy for reducing pulmonary edema secondary to chemical inhalation. In an experimental model of acute lung injury induced by exposure of anesthetized swine to chlorine gas by mechanical ventilation, the dose-dependent effects of TRPV4 inhibitor GSK2798745 were evaluated. Pulmonary function and oxygenation were measured hourly; airway responsiveness, wet-to-dry lung weight ratios, airway inflammation, and histopathology were assessed 24 h post-exposure...
April 2, 2024: International Journal of Molecular Sciences