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https://www.readbyqxmd.com/read/29040945/quercetin-protects-mouse-liver-against-triptolide-induced-hepatic-injury-by-restoring-th17-treg-balance-through-tim-3-and-tlr4-myd88-nf-%C3%AE%C2%BAb-pathway
#1
Cai-Bing Wei, Kun Tao, Rong Jiang, Lian-Di Zhou, Qi-Hui Zhang, Chun-Su Yuan
Triptolide (TP) is a diterpene triepoxide with various biological activities, but its clinical applications have been limited by potential hepatotoxicity, which can be attributed to T helper 17 (Th17)/T regulatory (Treg) cell imbalance. Quercetin (QE), a natural flavonoid, has been reported to have many benefits and medicinal properties, including hepatoprotective activity against TP-induced liver injury. However, the hepatoprotection mechanisms have not been clarified. The present study was designed to explore the protective effect and the mechanism of QE against TP-induced liver injury...
October 14, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29040852/blackwater-treatment-using-vertical-greening-efficiency-and-microbial-community-structure
#2
Zhan Jin, Xinyu Xie, Jin Zhou, Ke Bei, Yejian Zhang, Xianfeng Huang, Min Zhao, Hainan Kong, Xiangyong Zheng
This study assesses the use of vertical greening for blackwater treatment. The effects of hydraulic retention time (HRT) and drip frequency on treatment performance were systematically studied. Additionally, microbial communities in the vertical greening system were characterized. The results show that the removal efficiencies of NH4(+)-N and total phosphate (TP) increased with an increase in HRT, and the drip frequency had a significant effect on TP. High-throughput sequencing revealed that the diversity of the microbial community did not change significantly along vertical and horizontal directions, but the dominant species shifted...
September 28, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29040796/an-anterior-posterior-axis-within-the-ventromedial-prefrontal-cortex-separates-self-and-reward
#3
Alla Yankouskaya, Glyn Humphreys, Moritz Stolte, Mark Stokes, Zargol Moradi, Jie Sui
Although theoretical discourse and experimental studies on the self and reward biases have a long tradition, currently we have only a limited understanding of how the biases are represented in the brain and, more importantly, how they relate to each other. We used multi-voxel pattern analysis to test for common representations of self and reward in perceptual matching in healthy human subjects. Voxels across an anterior-posterior axis in ventromedial prefrontal cortex (vmPFC) distinguished (i) self-others and (ii) high-low reward, but cross generalization between these dimensions decreased from anterior to posterior vmPFC...
October 10, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/29040755/the-omics-dashboard-for-interactive-exploration-of-gene-expression-data
#4
Suzanne Paley, Karen Parker, Aaron Spaulding, Jean-Francois Tomb, Paul O'Maille, Peter D Karp
The Omics Dashboard is a software tool for interactive exploration and analysis of gene-expression datasets. The Omics Dashboard is organized as a hierarchy of cellular systems. At the highest level of the hierarchy the Dashboard contains graphical panels depicting systems such as biosynthesis, energy metabolism, regulation and central dogma. Each of those panels contains a series of X-Y plots depicting expression levels of subsystems of that panel, e.g. subsystems within the central dogma panel include transcription, translation and protein maturation and folding...
October 13, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29040749/cdc42-regulates-the-cellular-localization-of-cdc42ep1-in-controlling-neural-crest-cell-migration
#5
Cohen Shlomi, Daniel T Kovari, Wenbin Wei, Rebecca Keate, Jennifer E Curtis, Shuyi Nie
The member of Rho family of small GTPases Cdc42 plays important and conserved roles in cell polarity and motility. The Cdc42ep family proteins have been identified to bind to Cdc42, yet how they interact with Cdc42 to regulate cell migration remains to be elucidated. In this study, we focus on Cdc42ep1, which is expressed predominantly in the highly migratory neural crest cells in frog embryos. Through morpholino-mediated knockdown, we show that Cdc42ep1 is required for the migration of cranial neural crest cells...
October 6, 2017: Journal of Molecular Cell Biology
https://www.readbyqxmd.com/read/29040745/the-impact-of-shift-work-on-sleep-quality-among-nurses
#6
K McDowall, E Murphy, K Anderson
Background: Shift work is common among nurses, and it is known to be a workplace hazard as it may cause poor sleep quality, which can impact adversely on the health and safety of nurses and their patients. Aims: To explore factors that contribute to poor sleep quality in shift working nurses (SWNs) compared with non-shift working nurses (NSWNs) and to assess the awareness of support from occupational health. Methods: Cross-sectional study of nurses at a National Health Service (NHS) foundation trust, February to March 2016...
October 10, 2017: Occupational Medicine
https://www.readbyqxmd.com/read/29040739/papaya-cpein3a-and-cpnac2-cooperatively-regulate-carotenoid-biosynthesis-related-genes-cppds2-4-cplcy-e-and-cpchy-b-during-fruit-ripening
#7
Chang-Chun Fu, Yan-Chao Han, Jian-Fei Kuang, Jian-Ye Chen, Wang-Jin Lu
Papaya is an important tropical fruit with a rich source of carotenoids. The ripening of papaya is a physiological and metabolic process with remarkable changes including carotenoids accumulation, which depends primarily on the action of ethylene. Ethylene response is mediated by a transcriptional cascade involving the transcription factor families of EIN3/EILs and ERFs. Although ERF members have been reported to control carotenoids production in Arabidopsis and tomato, whether EIN3/EILs are also involved in carotenoid biosynthesis during fruit ripening remains unclear...
October 12, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/29040596/high-fidelity-phenotyping-richness-and-freedom-from-bias
#8
George Hripcsak, David J Albers
Electronic health record phenotyping is the use of raw electronic health record data to assert characterizations about patients. Researchers have been doing it since the beginning of biomedical informatics, under different names. Phenotyping will benefit from an increasing focus on fidelity, both in the sense of increasing richness, such as measured levels, degree or severity, timing, probability, or conceptual relationships, and in the sense of reducing bias. Research agendas should shift from merely improving binary assignment to studying and improving richer representations...
October 12, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29040577/metabolomics-of-postprandial-plasma-alterations-a-comprehensive-japanese-study
#9
Takeo Moriya, Yoshinori Satomi, Hiroyuki Kobayashi
While endogenous metabolites in plasma can be used as clinical biomarkers, intra-day variations should be carefully considered. The postprandial effect is a large contributing factor and is dependent on regional features (e.g., meals, ethnicity). Thus, for clinical application, regional-specific postprandial baseline data are required. In this study, 10 healthy Japanese volunteers of different ages and genders ate the same meal, and blood samples were taken 30 min before and one hour after the meal challenge...
October 4, 2017: Journal of Biochemistry
https://www.readbyqxmd.com/read/29040510/genomic-fragmentation-and-extrachromosomal-telomeric-repeats-impact-assessment-of-telomere-length-in-human-spermatozoa-quantitative-experiments-and-systematic-review
#10
P Kurjanowicz, S Moskovtsev, C Librach
STUDY QUESTION: Can differences in DNA isolation alter assessment of sperm telomere length (spTL) and do they account for conflicting results in the literature on spTL and male fertility? SUMMARY ANSWER: DNA isolation methods preferentially include or exclude short, extrachromosomal (EC) telomere-specific sequences that alter spTL measurements, and are responsible for a proportion of the disparity observed between investigations. WHAT IS KNOWN ALREADY: The relationship between spTL and male fertility has become an active area of research...
September 29, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29040476/national-responses-to-global-health-targets-exploring-policy-transfer-in-the-context-of-the-unaids-90-90-90-treatment-targets-in-ghana-and-uganda
#11
Ellen McRobie, Fred Matovu, Aisha Nanyiti, Justice Nonvignon, Daniel Nana Yaw Abankwah, Kelsey K Case, Timothy B Hallett, Johanna Hanefeld, Lesong Conteh
Global health organizations frequently set disease-specific targets with the goal of eliciting adoption at the national-level; consideration of the influence of target setting on national policies, programme and health budgets is of benefit to those setting targets and those intended to respond. In 2014, the Joint United Nations Programme on HIV/AIDS set 'ambitious' treatment targets for country adoption: 90% of HIV-positive persons should know their status; 90% of those on treatment; 90% of those achieving viral suppression...
October 11, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/29040451/an-omnibus-test-for-differential-distribution-analysis-of-microbiome-sequencing-data
#12
Jun Chen, Emily King, Rebecca Deek, Zhi Wei, Yue Yu, Diane Grill, Karla Ballman
Motivation: One objective of human microbiome studies is to identify differentially abundant microbes across biological conditions. Previous statistical methods focus on detecting the shift in the abundance and/or prevalence of the microbes and treat the dispersion (spread of the data) as a nuisance. These methods also assume that the dispersion is the same across conditions, an assumption which may not hold in presence of sample heterogeneity. Moreover, the widespread outliers in the microbiome sequencing data make existing parametric models not overly robust...
October 12, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29040398/correlation-of-blood-pressure-variability-as-measured-by-clinic-self-measurement-at-home-and-ambulatory-blood-pressure-monitoring
#13
J Abellán-Huerta, L Prieto-Valiente, S Montoro-García, J Abellán-Alemán, F Soria-Arcos
Background: Blood pressure variability (BPV) has been postulated as a potential predictor of cardiovascular outcomes. No agreement exists as to which measurement method is best for BPV estimation. We attempt to assess the correlation between BPV obtained at the doctor's office, self-measurement at home (SMBP) and ambulatory BP monitoring (ABPM). Methods: Eight weekly clinic BP measurements, two SMBP series and one 24-hour ABPM recording were carried out in a sample of treated hypertensive patients...
October 10, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/29040389/the-anti-epileptic-ketogenic-diet-alters-hippocampal-transporter-levels-and-reduces-adiposity-in-aged-rats
#14
Abbi R Hernandez, Caesar M Hernandez, Keila T Campos, Leah M Truckenbrod, Yasemin Sakarya, Joseph A McQuail Ph D, Christy S Carter, Jennifer L Bizon, Andrew P Maurer, Sara N Burke
Nutritional ketosis is induced by high fat/low carbohydrate dietary regimens, which produce high levels of circulating ketone bodies, shifting metabolism away from glucose utilization. While ketogenic diets (KD) were initially introduced to suppress seizures, they are garnering attention for their potential to treat a myriad of neurodegenerative and metabolic disorders that are associated with advanced age. The feasibility and physiological impact of implementing a long-term KD in old animals, however, has not been systematically examined...
October 12, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29040382/generalized-correlation-measure-using-count-statistics-for-gene-expression-data-with-ordered-samples
#15
Y X Rachel Wang, Ke Liu, Elizabeth Theusch, Jerome I Rotter, Marisa W Medina, Michael S Waterman, Haiyan Huang
Motivation: Capturing association patterns in gene expression levels under different conditions or time points is important for inferring gene regulatory interactions. In practice, temporal changes in gene expression may result in complex association patterns that require more sophisticated detection methods than simple correlation measures. For instance, the effect of regulation may lead to time-lagged associations and interactions local to a subset of samples. Furthermore, expression profiles of interest may not be aligned or directly comparable (e...
October 12, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29040376/aegs-identifying-aberrantly-expressed-gene-sets-for-differential-variability-analysis
#16
Jinting Guan, Moliang Chen, Congting Ye, James J Cai, Guoli Ji
Motivation: In gene expression studies, differential expression (DE) analysis has been widely used to identify genes with shifted expression mean between groups. Recently, differential variability (DV) analysis has been increasingly applied as analyzing changed expression variability (e.g., the changes in expression variance) between groups may reveal underlying genetic heterogeneity and undetected interactions, which has great implications in many fields of biology. An easy-to-use tool for DV analysis is needed...
October 11, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29040340/measuring-local-depletion-of-terrestrial-game-vertebrates-by-central-place-hunters-in-rural-amazonia
#17
Mark I Abrahams, Carlos A Peres, Hugo C M Costa
The degree to which terrestrial vertebrate populations are depleted in tropical forests occupied by human communities has been the subject of an intense polarising debate that has important conservation implications. Conservation ecologists and practitioners are divided over the extent to which community-based subsistence offtake is compatible with ecologically functional populations of tropical forest game species. To quantify depletion envelopes of forest vertebrates around human communities, we deployed a total of 383 camera trap stations and 78 quantitative interviews to survey the peri-community areas controlled by 60 semi-subsistence communities over a combined area of over 3...
2017: PloS One
https://www.readbyqxmd.com/read/29040273/schistosoma-japonicum-transmission-risk-maps-at-present-and-under-climate-change-in-mainland-china
#18
Gengping Zhu, Jingyu Fan, A Townsend Peterson
BACKGROUND: The South-to-North Water Diversion (SNWD) project is designed to channel fresh water from the Yangtze River north to more industrialized parts of China. An important question is whether future climate change and dispersal via the SNWD may synergistically favor a northward expansion of species involved in hosting and transmitting schistosomiasis in China, specifically the intermediate host, Oncomelania hupensis. METHODOLOGY/ PRINCIPAL FINDINGS: In this study, climate spaces occupied by the four subspecies of O...
October 17, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29040188/phagocytosis-of-extracellular-vesicles-extruded-from-the-placenta-by-ovarian-cancer-cells-inhibits-growth-of-the-cancer-cells
#19
Qi Chen, Victoria Rutten, Wei-Tzu Cheng, Mancy Tong, Jia Wei, Peter Stone, Lai-Ming Ching, Lawrence W Chamley
OBJECTIVE: Ovarian cancer is a common gynecological cancer, and parity is negatively associated with the incidence of this disease. This negative association is hypothesized to be due in part to shifting the balance of estrogen and progesterone toward more progesterone and reduced ovulation during pregnancy. However, studies suggested that parity is also associated with estrogen-independent gynecological cancers suggesting balance of hormones may not be the only protective factor. Extracellular vesicles (EVs) play an important role in cell-to-cell communication in physiological and pathological conditions...
October 17, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29040014/spatially-selective-alpha-oscillations-reveal-moment-by-moment-trade-offs-between-working-memory-and-attention
#20
Dirk van Moorselaar, Joshua J Foster, David W Sutterer, Jan Theeuwes, Christian N L Olivers, Edward Awh
Current theories assume a functional role for covert attention in the maintenance of spatial information in working memory. Consistent with this view, both the locus of attention and positions stored in working memory can be decoded based on the topography of oscillatory alpha-band (8-12 Hz) activity on the scalp. Thus far however, alpha modulation has been studied in isolation for covert attention and working memory tasks. Here, we applied an inverted spatial encoding model in combination with EEG to study the temporal dynamics of spatially specific alpha activity during a task that required observers to visually select a target location while maintaining another independently varying location in working memory...
October 17, 2017: Journal of Cognitive Neuroscience
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