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https://www.readbyqxmd.com/read/29220874/evolution-of-larval-competitiveness-and-associated-life-history-traits-in-response-to-host-shifts-in-a-seed-beetle
#1
Charles W Fox, Frank J Messina
Resource competition is frequently strong among parasites that feed within small discrete resource patches, such as seeds or fruits. The properties of a host can influence the behavioral, morphological, and life history traits of associated parasites, including traits that mediate competition within the host. For seed parasites, host size may be an especially important determinant of competitive ability. Using the seed beetle, Callosobruchus maculatus, we performed replicated, reciprocal host shifts to examine the role of seed size in determining larval competitiveness and associated traits...
December 8, 2017: Journal of Evolutionary Biology
https://www.readbyqxmd.com/read/29220820/application-of-an-in-situ-soil-sampler-for-assessing-subsurface-biogeochemical-dynamics-in-a-diesel-contaminated-coastal-site-during-soil-flushing-operations
#2
Man Jae Kwon, Edward J O'Loughlin, Baknoon Ham, Yunho Hwang, Moojoon Shim, Soonjae Lee
Subsurface biogeochemistry and contaminant dynamics during the remediation of diesel-contamination by in-situ soil flushing were investigated at a site located in a coastal region. An in-situ sampler containing diesel-contaminated soils separated into two size fractions (<0.063- and <2-mm) was utilized in two monitoring wells: DH1 (located close to the injection and extraction wells for in-situ soil flushing) and DH2 (located beyond sheet piles placed to block the transport of leaked diesel). Total petroleum hydrocarbon (TPH) concentrations and biogeochemical properties were monitored both in soil and groundwater for six months...
December 5, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/29220706/swing-voting-in-the-2016-presidential-election-in-counties-where-midlife-mortality-has-been-rising-in-white-non-hispanic-americans
#3
Usama Bilal, Emily A Knapp, Richard S Cooper
Understanding the effects of widespread disruption of the social fabric on public health outcomes can provide insight into the forces that drive major political realignment. Our objective was to estimate the association between increases in mortality in middle-aged non-Hispanic white adults from 1999 to 2005 to 2009-2015, health inequalities in life expectancy by income, and the surge in support for the Republican Party in pivotal US counties in the 2016 presidential election. We conducted a longitudinal ecological study in 2764 US counties from 1999 to 2016...
December 2, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/29220671/structural-comparison-among-the-2013-2017-avian-influenza-a-h5n6-hemagglutinin-proteins-a-computational-study-with-epidemiological-implications
#4
Marni E Cueno, Izuho Suzuki, Shiori Shimotomai, Takuma Yokoyama, Kai Nagahisa, Kenichi Imai
Avian influenza viruses easily spread allowing viral re-assortment to simply occur which in-turn increases the potential for a pandemic. A novel 2013 H5N6 influenza strain was detected among the avian population and was reported to continuously evolve, however, this was never structurally demonstrated. Here, we elucidated the putative structural evolution of the novel H5N6 influenza strain. Throughout this study, we analyzed 2013-2017 H5N6 HA protein models. Model quality was first verified before further analyses and structural comparison was made using superimposition...
November 28, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29220666/chromatin-accessibility-dynamics-during-ipsc-reprogramming
#5
Dongwei Li, Jing Liu, Xuejie Yang, Chunhua Zhou, Jing Guo, Chuman Wu, Yue Qin, Lin Guo, Jiangping He, Shenyong Yu, He Liu, Xiaoshan Wang, Fang Wu, Junqi Kuang, Andrew P Hutchins, Jiekai Chen, Duanqing Pei
Cell-fate decisions remain poorly understood at the chromatin level. Here, we map chromatin remodeling dynamics during induction of pluripotent stem cells. ATAC-seq profiling of MEFs expressing Oct4-Sox2-Klf4 (OSK) reveals dynamic changes in chromatin states shifting from open to closed (OC) and closed to open (CO), with an initial burst of OC and an ending surge of CO. The OC loci are largely composed of genes associated with a somatic fate, while the CO loci are associated with pluripotency. Factors/conditions known to impede reprogramming prevent OSK-driven OC and skew OC-CO dynamics...
December 7, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/29220582/accounting-for-men-s-refusal-of-heterosex-a-story-completion-study-with-young-adults
#6
Melanie Ann Beres, Gareth Terry, Charlene Y Senn, Lily Kay Ross
In the present study we bring together theory regarding the construction of heterosexuality and masculinities to understand the shifting and changing terrain of heterosexual sex (heterosex). We use inductive qualitative content analysis of story completion data to discover the different ways that heterosex is constructed by the male and female respondents in scenarios where women initiate sex and men, at first, refuse. The stories represented a spectrum of responses that reify and subvert dominant understandings of heterosex...
December 8, 2017: Journal of Sex Research
https://www.readbyqxmd.com/read/29220483/prenatal-exposure-to-bisphenol-a-disrupts-naturally-occurring-bimodal-dna-methylation-at-proximal-promoter-of-fggy-an-obesity-relevant-gene-encoding-a-carbohydrate-kinase-in-gonadal-white-adipose-tissues-of-cd-1-mice
#7
Julia A Taylor, Keiko Shioda, Shino Mitsunaga, Shiomi Yawata, Brittany M Angle, Susan C Nagel, Frederick S Vom Saal, Toshi Shioda
Exposure of mammalian fetuses to endocrine disruptors can increase the risk of adult-onset diseases. For example, we previously showed that exposure of mouse fetuses to bisphenol A (BPA) caused adult-onset obesity. To obtain insights into roles of epigenetic changes in the delayed toxic effects of endocrine disruption, we determined effects of fetal mouse exposure to BPA on genome-wide DNA methylation and mRNA expression in gonadal white adipose tissues by deep sequencing (MBD-seq and RNA-seq), bisulfite pyrosequencing, and real-time qPCR...
December 6, 2017: Endocrinology
https://www.readbyqxmd.com/read/29220416/the-effectiveness-and-limitation-of-the-national-childhood-hepatitis-a-vaccination-program-in-the-republic-of-korea-findings-from-the-korean-national-health-and-nutrition-examination-survey-knhanes-2015
#8
Juwon Lim, Kyuwoong Kim, Seulggie Choi, Sang Min Park
BACKGROUND: Vaccination for hepatitis A virus (HAV) has been implemented as one of the national vaccination programs despite the epidemiological transition of HAV in the Republic of Korea. While the national HAV vaccination program is largely associated with the shift of socioeconomic trend in the country, concerns have been raised on the effectiveness of the HAV immunization. The objective of this study was to examine the epidemiological trend of HAV and assess the effectiveness of the nationwide HAV vaccination policy based on a nationally representative sample of the Korean population collected in 2015...
2017: PloS One
https://www.readbyqxmd.com/read/29220397/desethylamiodarone-a-metabolite-of-amiodarone-induces-apoptosis-on-t24-human-bladder-cancer-cells-via-multiple-pathways
#9
Zita Bognar, Katalin Fekete, Csenge Antus, Eniko Hocsak, Rita Bognar, Antal Tapodi, Arpad Boronkai, Nelli Farkas, Ferenc Gallyas, Balazs Sumegi, Arpad Szanto
Bladder cancer (BC) is a common malignancy of the urinary tract that has a higher frequency in men than in women. Cytostatic resistance and metastasis formation are significant risk factors in BC therapy; therefore, there is great interest in overcoming drug resistance and in initiating research for novel chemotherapeutic approaches. Here, we suggest that desethylamiodarone (DEA)-a metabolite of amiodarone-may have cytostatic potential. DEA activates the collapse of mitochondrial membrane potential (detected by JC-1 fluorescence), and induces cell death in T24 human transitional-cell bladder carcinoma cell line at physiologically achievable concentrations...
2017: PloS One
https://www.readbyqxmd.com/read/29220372/the-monomeric-form-of-neisseria-dna-mimic-protein-dmp19-prevents-dna-from-binding-to-the-histone-like-hu-protein
#10
Ming-Fen Huang, Shin-Jen Lin, Tzu-Ping Ko, Yi-Ting Liao, Kai-Cheng Hsu, Hao-Ching Wang
DNA mimicry is a direct and effective strategy by which the mimic competes with DNA for the DNA binding sites on other proteins. Until now, only about a dozen proteins have been shown to function via this strategy, including the DNA mimic protein DMP19 from Neisseria meningitides. We have shown previously that DMP19 dimer prevents the operator DNA from binding to the transcription factor NHTF. Here, we provide new evidence that DMP19 monomer can also interact with the Neisseria nucleoid-associated protein HU...
2017: PloS One
https://www.readbyqxmd.com/read/29220359/synthesis-of-novel-purpurealidin-analogs-and-evaluation-of-their-effect-on-the-cancer-relevant-potassium-channel-kv10-1
#11
Lien Moreels, Chinmay Bhat, Manuela Voráčová, Steve Peigneur, Hannah Goovaerts, Eero Mäki-Lohiluoma, Farrah Zahed, Luis A Pardo, Jari Yli-Kauhaluoma, Paula Kiuru, Jan Tytgat
In the search for novel anticancer drugs, the potassium channel KV10.1 has emerged as an interesting cancer target. Here, we report a new group of KV10.1 inhibitors, namely the purpurealidin analogs. These alkaloids are produced by the Verongida sponges and are known for their wide variety of bioactivities. In this study, we describe the synthesis and characterization of 27 purpurealidin analogs. Structurally, bromine substituents at the central phenyl ring and a methoxy group at the distal phenyl ring seem to enhance the activity on KV10...
2017: PloS One
https://www.readbyqxmd.com/read/29220208/changing-utilization-of-noninvasive-diagnostic-imaging-over-2-decades-an-examination-family-focused-analysis-of-medicare-claims-using-the-neiman-imaging-types-of-service-categorization-system
#12
David A Rosman, Richard Duszak, Wenyi Wang, Danny R Hughes, Andrew B Rosenkrantz
OBJECTIVE: The objective of our study was to use a new modality and body region categorization system to assess changing utilization of noninvasive diagnostic imaging in the Medicare fee-for-service population over a recent 20-year period (1994-2013). MATERIALS AND METHODS: All Medicare Part B Physician Fee Schedule services billed between 1994 and 2013 were identified using Physician/Supplier Procedure Summary master files. Billed codes for diagnostic imaging were classified using the Neiman Imaging Types of Service (NITOS) coding system by both modality and body region...
December 8, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29218637/specific-phosphorothioate-substitution-within-domain-6-of-a-group-ii-intron-ribozyme-leads-to-changes-in-local-structure-and-metal-ion-binding
#13
Michèle C Erat, Emina Besic, Michael Oberhuber, Silke Johannsen, Roland K O Sigel
Group II introns are large self-splicing ribozymes that require high amounts of monovalent and divalent metal ions for folding and catalysis under in vitro conditions. Domain 6 of these ribozymes contains a highly conserved adenosine whose 2'-OH acts as a nucleophile during self-cleavage via the branching pathway. We have previously suggested a divalent metal ion that binds to the major groove at the GU wobble pair above the branch-A in a minimal, but active branch domain construct (D6-27) from the yeast mitochondrial intron Sc...
December 7, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/29218633/characterization-of-the-one-electron-oxidized-cu-ii-salen-complexes-with-a-side-chain-aromatic-ring-the-effect-of-the-indole-ring-on-the-cu-ii-phenoxyl-radical-species
#14
Hiromi Oshita, Takayoshi Yoshimura, Seiji Mori, Fumito Tani, Yuichi Shimazaki, Osamu Yamauchi
To gain insights into the role of the proximal indole ring in the redox-active metal center as seen in galactose oxidase, we prepared the Cu(II)-salen-type complexes having a pendent indol-3-ylmethyl (1), methyl (2) or benzyl (3) group substituted on the ethylenediamine moiety and investigated the structures and redox properties by various physicochemical methods and theoretical calculations. Neutral complexes 1, 2, and 3 showed no significant difference in the UV-Vis-NIR and EPR spectra. One-electron oxidation of 1, 2, and 3 by addition of 1 equiv...
December 7, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/29218585/analyzing-the-kinematics-of-hand-movements-in-catching-tasks-an-online-correction-analysis-of-movement-toward-the-target-s-trajectory
#15
Lena Slupinski, Marc H E de Lussanet, Heiko Wagner
Free, 3-D interceptive movements are difficult to visualize and quantify. For ball catching, the endpoint of a movement can be anywhere along the target's trajectory. Furthermore, the hand may already have begun to move before the subject has estimated the target's trajectory, and the subject may alter the targeted position during the initial part of the movement. We introduce a method to deal with these difficulties and to quantify three movement phases involved in catching: the initial, non-goal-directed phase; the goal-directed phase, which is smoothly directed toward the target's trajectory; and the final, interception phase...
December 7, 2017: Behavior Research Methods
https://www.readbyqxmd.com/read/29218582/application-of-fluorescence-emission-for-characterization-of-albendazole-and-ricobendazole-micellar-systems-elucidation-of-the-molecular-mechanism-of-drug-solubilization-process
#16
Josefina Priotti, Darío Leonardi, Guillermo Pico, María C Lamas
Albendazole (ABZ) and ricobendazole (RBZ) are referred to as class II compounds in the Biopharmaceutical Classification System. These drugs exhibit poor solubility, which profoundly affects their oral bioavailability. Micellar systems are excellent pharmaceutical tools to enhance solubilization and absorption of poorly soluble compounds. Polysorbate 80 (P80), poloxamer 407 (P407), sodium cholate (Na-C), and sodium deoxycholate (Na-DC) have been selected as surfactants to study the solubilization process of these drugs...
December 7, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29218452/inhibition-of-the-k-conductance-and-cole-moore-shift-of-the-oncogenic-kv10-1-channel-by-amiodarone
#17
C Barriga-Montoya, A Huanosta-Gutiérrez, A Reyes-Vaca, A Hernández-Cruz, A Picones, F Gómez-Lagunas
The ectopic overexpression of the voltage-dependent Eag1 (Kv10.1) K+ channel is associated with the cancerous phenotype in about 70% of human cancers and tumor cell lines. Recent reports showed that, compared with the canonical Shaker-related Kv family, Kv10.1 presents unique structural and functional properties. Herein, we report the interaction of the class III anti-arrhythmic compound amiodarone with Kv10.1. Using whole-cell patch clamp, we found that amiodarone inhibits Kv10.1 channel conductance with nanomolar affinity...
December 7, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/29218351/synthesis-and-characterization-of-pyrrolyldipyrrin-f-bodipys
#18
Sarah M Greening, Katherine N Robertson, Alison Thompson
A series of synthetic analogs of the tripyrrolic natural product prodigiosin were complexed with boron trifluoride to generate the corresponding F-BODIPYs. The maximum wavelengths of absorption and emission of the pyrrolyldipyrrin F-BODIPYs were tuned through variation of the substituents about the pyrrolyldipyrrinato core. The limited variation of substituents on the C-ring did not significantly affect absorption and emission. However, variation of substituents on the B-ring and A-ring resulted in a corresponding red-shift in absorption and emission reaching maximum wavelengths of 600 nm...
December 8, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/29218340/coexisting-properties-of-thermostability-and-ultraviolet-radiation-resistance-in-the-main-s-layer-complex-of-deinococcus-radiodurans
#19
Domenica Farci, Chavdar Slavov, Dario Piano
Deinococcus radiodurans is well known for its unusual resistance to different environmental stresses. Recently, we have described a novel complex composed of the surface (S)-layer protein DR_2577 and the carotenoid deinoxanthin. We also showed a role of this complex in the UV resistance under desiccation. Both these properties, UV and desiccation resistance, suggest a selective pressure generated by Sun irradiation. In order to confirm this hypothesis we checked whether this S-layer Deinoxanthin Binding Complex (SDBC) has features of thermo-resistance, a property also expected in proteins evolved under solar irradiative pressure...
December 8, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/29218262/neurologic-outcomes-following-care-in-the-pediatric-intensive-care-unit
#20
Sherrill D Caprarola, Sapna R Kudchadkar, Melania M Bembea
Purpose of review: With increasing survival of children requiring admission to pediatric intensive care units (PICU), neurodevelopmental outcomes of these patients are an area of increased attention. Our goal was to systematically review recently published literature on neurologic outcomes of PICU patients. Recent Findings: Decline in neurofunctional status occurs in 3%-20% of children requiring PICU care. This proportion varies based on primary diagnosis and severity of illness, with children admitted for primary neurologic diagnosis, children who suffer cardiac arrest or who require invasive interventions during the PICU admission, having worse outcomes...
September 2017: Current Treatment Options in Pediatrics
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