keyword
MENU ▼
Read by QxMD icon Read
search

Cortactin

keyword
https://www.readbyqxmd.com/read/29774130/targeting-invadopodia-mediated-breast-cancer-metastasis-by-using-abl-kinase-inhibitors
#1
Tomer Meirson, Alessandro Genna, Nikola Lukic, Tetiana Makhnii, Joel Alter, Ved P Sharma, Yarong Wang, Abraham O Samson, John S Condeelis, Hava Gil-Henn
Metastatic dissemination of cancer cells from the primary tumor and their spread to distant sites in the body is the leading cause of mortality in breast cancer patients. While researchers have identified treatments that shrink or slow metastatic tumors, no treatment that permanently eradicates metastasis exists at present. Here, we show that the ABL kinase inhibitors imatinib, nilotinib, and GNF-5 impede invadopodium precursor formation and cortactin-phosphorylation dependent invadopodium maturation, leading to decreased actin polymerization in invadopodia, reduced extracellular matrix degradation, and impaired matrix proteolysis-dependent invasion...
April 24, 2018: Oncotarget
https://www.readbyqxmd.com/read/29765546/proteomic-screening-identifies-the-zonula-occludens-protein-zo-1-as-a-new-partner-for-adam12-in-invadopodia-like-structures
#2
Bassil Dekky, Michael Ruff, Dominique Bonnier, Vincent Legagneux, Nathalie Théret
The epithelial mesenchymal transition (EMT) is a key process for cancer cell invasion and migration. This complex program whereby epithelial tumor cells loose polarity and acquire mesenchymal phenotype is driven by the regulation of cell-cell adhesion and cell-substrate interactions. We recently described the association of ADAM12 with EMT and we now use immunoprecipitation and proteomic approaches to identify interacting partners for ADAM12 during EMT. We identify twenty proteins that are involved in molecular mechanisms associated with adhesion/invasion processes...
April 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29758926/plasma-ccl5-promotes-emt-medicated-epirubicin-resistance-in-locally-advanced-breast-cancer
#3
Ge Ma, Huaxing Huang, Minghui Li, Li Li, Peng Kong, Yichao Zhu, Tiansong Xia, Shui Wang
Neoadjuvant chemotherapy (NCT) is the standard treatment for locally advanced breast cancer (LABC). Pathological complete response (pCR) is commonly used as a valid predictor of NCT long-term outcomes. Blood-based tumor biomarkers have the potential to predict response to NCT at early stage non-invasively. We believed plasma CCL5 could be a potential marker to predict NCT of LABC. Its efficiency and possible mechanism was studied in this work. Human Cytokine Antibody Microarray was applied to screen different cytokine concentration in plasma between low histological regression (Low-R) and high histological regression (High-R) patients...
May 4, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29658350/vascular-endothelial-growth-factor-c-promotes-cervical-cancer-cell-invasiveness-via-regulation-of-microrna-326-cortactin-expression
#4
Yang Cheng, Shuyi Jiang, Jin Yuan, Junxiu Liu, Tommaso Simoncini
Vascular endothelial growth factor C (VEGF-C) accelerates cervical cancer metastasis, while the detailed mechanism remains largely unknown. Recent evidence indicates that microRNA play a crucial role in controlling cancer cell invasiveness. In the present study, we investigated the role of miR-326 in VEGF-C-induced cervical cancer cell invasion. VEGF-C expression was higher and miR-326 was much lower in primary cervical cancer specimens than that in non-cancerous specimens, and a negative correlation between VEGF-C and miR-326 was found...
April 16, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29651632/high-expression-of-fbp17-in-invasive-breast-cancer-cells-promotes-invadopodia-formation
#5
Prabhat Suman, Sarthak Mishra, Harish Chander
Metastatic spread of the cancer is usually the consequence of the activation of signaling pathways that generate cell motility and tissue invasion. Metastasis involves the reorganization of cytoskeleton and cell shape for the swift movement of the cells through extracellular matrix. Previously, we have described the invasive and metastatic role played by one of the members (Toca-1) of CIP4 subfamily of F-BAR proteins. In the present study, we address the role of another member (FBP17) of same family in the invasion breast cancer cells...
April 12, 2018: Medical Oncology
https://www.readbyqxmd.com/read/29644904/survivin-and-cortactin-expression-in-sinonasal-schneiderian-inverted-papilloma-and-associated-carcinoma
#6
Gino Marioni, Giuseppe Brescia, Lorenzo Nicolè, Rosario Marchese-Ragona, Umberto Barion, Luciano Giacomelli, Filippo Marino, Alessandro Martini, Giancarlo Ottaviano
BACKGROUND: Sinonasal inverted (schneiderian) papilloma (IP) is histologically benign but shows a propensity for malignant transformation. Survivin, a member of the inhibitor of the apoptosis family of proteins that controls cell division, apoptosis, metastasis, and, probably, also neoangiogenesis, is overexpressed in essentially all human cancers. Overexpression of the multidomain protein cortactin has also been associated with increased cell migration, invasion, and metastatic potential in several malignancies...
March 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29643476/inhibition-of-ovarian-tumor-cell-invasiveness-by-targeting-syk-in-the-tyrosine-kinase-signaling-pathway
#7
Yu Yu, Yohan Suryo Rahmanto, Meng-Horng Lee, Pei-Hsun Wu, Jude M Phillip, Chuan-Hsiang Huang, Michele I Vitolo, Stephanie Gaillard, Stuart S Martin, Denis Wirtz, Ie-Ming Shih, Tian-Li Wang
Cell motility and invasiveness are prerequisites for dissemination, and largely account for cancer mortality. We have identified an actionable kinase, spleen tyrosine kinase (SYK), which is keenly tightly associated with tumor progression in ovarian cancer. Here, we report that active recombinant SYK directly phosphorylates cortactin and cofilin, which are critically involved in assembly and dynamics of actin filament through phosphorylation signaling. Enhancing SYK activity by inducing expression of a constitutively active SYK mutant, SYK130E , increased growth factor-stimulated migration and invasion of ovarian cancer cells, which was abrogated by cortactin knockdown...
April 11, 2018: Oncogene
https://www.readbyqxmd.com/read/29590602/ecm-cross-linking-regulates-invadopodia-dynamics
#8
Kamyar Esmaeili Pourfarhangi, Aviv Bergman, Bojana Gligorijevic
Invadopodia are membrane protrusions dynamically assembled by invasive cancer cells in contact with the extracellular matrix (ECM). Invadopodia are enriched by the structural proteins actin and cortactin as well as metalloproteases such as MT1-MMP, whose function is to degrade the surrounding ECM. During metastasis, invadopodia are necessary for cancer cell intravasation and extravasation. Although signaling pathways involved in the assembly and function of invadopodia are well studied, few studies address invadopodia dynamics and how the cell-ECM interactions contribute to cell invasion...
March 27, 2018: Biophysical Journal
https://www.readbyqxmd.com/read/29567535/nanobodies-targeting-cortactin-proline-rich-helical-and-actin-binding-regions-downregulate-invadopodium-formation-and-matrix-degradation-in-scc-61-cancer-cells
#9
Laurence Bertier, Tim Hebbrecht, Elien Mettepenningen, Natasja De Wit, Olivier Zwaenepoel, Adriaan Verhelle, Jan Gettemans
Cortactin is a multidomain actin binding protein that activates Arp2/3 mediated branched actin polymerization. This is essential for the formation of protrusive structures during cancer cell invasion. Invadopodia are cancer cell-specific membrane protrusions, specialized at extracellular matrix degradation and essential for invasion and tumor metastasis. Given the unequivocal role of cortactin at every stage of invadopodium formation, it is considered an invadopodium marker and potential drug target. We used cortactin nanobodies to examine the role of cortactin domain-specific function at endogenous protein level...
March 19, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29540831/fes-related-tyrosine-kinase-activates-the-insulin-like-growth-factor-1-receptor-at-sites-of-cell-adhesion
#10
Joanna Stanicka, Leonie Rieger, Sandra O'Shea, Orla Cox, Michael Coleman, Ciara O'Flanagan, Barbara Addario, Nuala McCabe, Richard Kennedy, Rosemary O'Connor
IGF-1 receptor (IGF-1R) and integrin cooperative signaling promotes cancer cell survival, proliferation, and motility, but whether this influences cancer progression and therapy responses is largely unknown. Here we investigated the non-receptor tyrosine adhesion kinase FES-related (FER), following its identification as a potential mediator of sensitivity to IGF-1R kinase inhibition in a functional siRNA screen. We found that FER and the IGF-1R co-locate in cells and can be co-immunoprecipitated. Ectopic FER expression strongly enhanced IGF-1R expression and phosphorylation on tyrosines 950 and 1131...
March 15, 2018: Oncogene
https://www.readbyqxmd.com/read/29535305/desmosomal-cadherin-association-with-tctex-1-and-cortactin-arp2-3-drives-perijunctional-actin-polymerization-to-promote-keratinocyte-delamination
#11
Oxana Nekrasova, Robert M Harmon, Joshua A Broussard, Jennifer L Koetsier, Lisa M Godsel, Gillian N Fitz, Margaret L Gardel, Kathleen J Green
The epidermis is a multi-layered epithelium that serves as a barrier against water loss and environmental insults. Its morphogenesis occurs through a tightly regulated program of biochemical and architectural changes during which basal cells commit to differentiate and move towards the skin's surface. Here, we reveal an unexpected role for the vertebrate cadherin desmoglein 1 (Dsg1) in remodeling the actin cytoskeleton to promote the transit of basal cells into the suprabasal layer through a process of delamination, one mechanism of epidermal stratification...
March 13, 2018: Nature Communications
https://www.readbyqxmd.com/read/29534838/cortactin-expression-in-nasal-polyps-of-aspirin-exacerbated-respiratory-disease-aerd-patients
#12
Giuseppe Brescia, Daniela Parrino, Lorenzo Nicolè, Claudia Zanotti, Cristiano Lanza, Umberto Barion, Filippo Marino, Gino Marioni
PURPOSE: The term aspirin-exacerbated respiratory disease (AERD) refers to a combination of asthma, chronic rhinosinusitis with nasal polyposis (CRSwNP), and acute respiratory tract reactions to nonsteroidal anti-inflammatory drugs. AERD has now been included among the CRSwNP endotypes, and is considered one of the most aggressive in terms of disease recurrence. Cortactin is a multi-domain protein with a part in several cellular mechanisms involving actin assembly and cytoskeleton arrangement...
May 2018: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29518361/open-up-to-make-new-contacts-caldendrin-senses-postsynaptic-calcium-influx-to-dynamically-organize-dendritic-spines
#13
Andrew Coleman, Thomas Biederer
In this issue of Neuron, Mikhaylova et al. (2018) report how the Ca2+ sensor caldendrin interacts in dendritic spines with cortactin to control actin remodeling. Combining molecular and functional approaches, this work gains insights into postsynaptic dynamics relevant for synaptic plasticity.
March 7, 2018: Neuron
https://www.readbyqxmd.com/read/29515177/cortactin-regulates-endo-lysosomal-sorting-of-ampars-via-direct-interaction-with-glua2-subunit
#14
Gabrielle T Parkinson, Sophie E L Chamberlain, Nadia Jaafari, Matthew Turvey, Jack R Mellor, Jonathan G Hanley
AMPA receptor (AMPAR) trafficking is a key determinant of synaptic strength and synaptic plasticity. Under basal conditions, constitutive trafficking maintains surface AMPARs by internalization into the endosomal system, where the majority are sorted and targeted for recycling back to the plasma membrane. NMDA receptor (NMDAR)-dependent Long-Term Depression (LTD) is characterised by a reduction in synaptic strength, and involves endosomal sorting of AMPARs away from recycling pathways to lysosomes. The mechanisms that determine whether AMPARs are trafficked to lysosomes or to recycling endosomes, especially in response to NMDAR stimulation, are unclear...
March 7, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29514104/large-scale-phosphoproteomics-reveals-shp-2-phosphatase-dependent-regulators-of-pdgf-receptor-signaling
#15
Tanveer S Batth, Moreno Papetti, Anamarija Pfeiffer, Maxim A X Tollenaere, Chiara Francavilla, Jesper V Olsen
Despite its low cellular abundance, phosphotyrosine (pTyr) regulates numerous cell signaling pathways in health and disease. We applied comprehensive phosphoproteomics to unravel differential regulators of receptor tyrosine kinase (RTK)-initiated signaling networks upon activation by Pdgf-ββ, Fgf-2, or Igf-1 and identified more than 40,000 phosphorylation sites, including many phosphotyrosine sites without additional enrichment. The analysis revealed RTK-specific regulation of hundreds of pTyr sites on key signaling molecules...
March 6, 2018: Cell Reports
https://www.readbyqxmd.com/read/29478916/caldendrin-directly-couples-postsynaptic-calcium-signals-to-actin-remodeling-in-dendritic-spines
#16
Marina Mikhaylova, Julia Bär, Bas van Bommel, Philipp Schätzle, PingAn YuanXiang, Rajeev Raman, Johannes Hradsky, Anja Konietzny, Egor Y Loktionov, Pasham Parameshwar Reddy, Jeffrey Lopez-Rojas, Christina Spilker, Oliver Kobler, Syed Ahsan Raza, Oliver Stork, Casper C Hoogenraad, Michael R Kreutz
Compartmentalization of calcium-dependent plasticity allows for rapid actin remodeling in dendritic spines. However, molecular mechanisms for the spatio-temporal regulation of filamentous actin (F-actin) dynamics by spinous Ca2+ -transients are still poorly defined. We show that the postsynaptic Ca2+ sensor caldendrin orchestrates nano-domain actin dynamics that are essential for actin remodeling in the early phase of long-term potentiation (LTP). Steep elevation in spinous [Ca2+ ]i disrupts an intramolecular interaction of caldendrin and allows cortactin binding...
March 7, 2018: Neuron
https://www.readbyqxmd.com/read/29377162/serological-and-experimental-studies-in-different-forms-of-myasthenia-gravis
#17
REVIEW
Angela Vincent, Saif Huda, Michelangelo Cao, Hakan Cetin, Inga Koneczny, Pedro Rodriguez-Cruz, Leslie Jacobson, Stuart Viegas, Saiju Jacob, Mark Woodhall, Akiko Nagaishi, Angelina Maniaol, Valentina Damato, M Isabel Leite, Judith Cossins, Richard Webster, Jacqueline Palace, David Beeson
Antibodies to the acetylcholine receptor (AChR) have been recognized for over 40 years and have been important in the diagnosis of myasthenia gravis (MG), and its recognition in patients of different ages and thymic pathologies. The 10-20% of patients who do not have AChR antibodies are now known to comprise different subgroups, the most commonly reported of which is patients with antibodies to muscle-specific kinase (MuSK). The use of cell-based assays has extended the repertoire of antibody tests to clustered AChRs, low-density lipoprotein receptor-related protein 4, and agrin...
February 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29374558/cortactin-recruits-fmnl2-to-promote-actin-polymerization-and-endosome-motility-in-invadopodia-formation
#18
X L Ren, Y D Qiao, J Y Li, X M Li, D Zhang, X J Zhang, X H Zhu, W J Zhou, J Shi, W Wang, W T Liao, Y Q Ding, L Liang
Recently, invadopodia have been increasingly recognized as important drivers of local invasion and metastasis. Cortactin, as an actin-binding protein, is closely associated with invadopodia through interacting with proteins. Formin-like 2 (FMNL2), a member of diaphanous-related formins which act as nucleation factors, plays an important role in tumor progression. But whether cortactin can interact with FMNL2 to promote invadopodia formation and the role of FMNL2 in invadopodia formation are still unknown. Here we found that cortactin directly bound to FMNL2 and elevated the activities of actin polymerization and recycling endosome motility...
April 10, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29343759/incorporation-of-iloprost-in-phospholipase-resistant-phospholipid-scaffold-enhances-its-barrier-protective-effects-on-pulmonary-endothelium
#19
Olga Oskolkova, Nicolene Sarich, Yufeng Tian, Grzegorz Gawlak, Fanyong Meng, Valery N Bochkov, Evgeny Berdyshev, Anna A Birukova, Konstantin G Birukov
Correction of barrier dysfunction and inflammation in acute lung injury (ALI) represents an important problem. Previous studies demonstrate barrier-protective and anti-inflammatory effects of bioactive lipid prostacyclin and its stable analog iloprost (ILO). We generated a phospholipase resistant synthetic phospholipid with iloprost attached at the sn-2 position (ILO-PC) and investigated its biological effects. In comparison to free ILO, ILO-PC caused sustained endothelial cell (EC) barrier enhancement, linked to more prolonged activation of Rap1 and Rac1 GTPases and their cytoskeletal and cell junction effectors: cortactin, PAK1, p120-catenin and VE-cadherin...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29338716/donor-age-affects-proteome-composition-of-tenocyte-derived-engineered-tendon
#20
Agnieszka J Turlo, Yalda Ashraf Kharaz, Peter D Clegg, James Anderson, Mandy J Peffers
BACKGROUND: The concept of tissue engineering is to deliver to the injury site biological scaffolds carrying functional cells that will enhance healing response. The preferred cell source is autologous in order to reduce immune response in the treated individual. However, in elderly patients age-related changes in synthetic activity of the implanted cells and subsequent alterations in tissue protein content may affect therapeutic outcomes. In this study we investigated the effect of donor age on proteome composition of tenocyte-derived tendon tissue-engineered constructs...
January 16, 2018: BMC Biotechnology
keyword
keyword
86035
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"