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Cortactin

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https://www.readbyqxmd.com/read/28166391/lactosamine-based-derivatives-as-tools-to-delineate-the-biological-functions-of-galectins-application-to-skin-tissue-repair
#1
Cyrille Grandjean, Johann Dion, Frédérique Deshayes, Nataliya Storozhylova, Tamara Advedissian, Annie Lambert, Mireille Viguier, Charles Tellier, Christophe Dussouy, Françoise Poirier
Galectins have been recognized as potential novel therapeutic targets in connection with the numerous fundamental biological processes which they are involved in. Galectins are key players of homeostasis and as such, their expression and function are finely tuned in vivo. As a consequence, their modes of action are complex and remain largely unexplored partly due the lack of dedicated tools. We thus thought to design galectin inhibitors from lactosamine core, functionalized at key C2 and C3' positions by aromatic subsituents to ensure both high affinity and selectivity, and equipped with a spacer which can be modified on demand to further modulate their intrinsic physico-chemical properties...
February 6, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28131549/cortactin-and-phosphorylated-cortactin-tyr-466-expression-in-temporal-bone-carcinoma
#2
Gino Marioni, Elisabetta Zanoletti, Antonio Mazzoni, Andrea Gianatti, Elisa Valentini, Laura Girasoli, Martina Guariento, Luciano Giacomelli, Alessandro Martini, Stella Blandamura
PURPOSE: Cortactin is a multidomain protein engaged in several cellular mechanisms involving actin assembly and cytoskeletal arrangement. Cortactin overexpression in several malignancies has been associated with increased cell migration, invasion, and metastatic potential. Cortactin needs to be activated by tyrosine or serine/threonine phosphorylation. The role of cortactin and phosphorylated cortactin (residue tyr(466)) was investigated in temporal bone squamous cell carcinoma (TBSCC)...
January 19, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28126411/perfluorooctanoic-acid-affects-endocytosis-involving-clathrin-light-chain-a-and-microrna-133b-3p-in-mouse-testes
#3
Yin Lu, Jianshe Wang, Xuejiang Guo, Shengmin Yan, Jiayin Dai
Perfluorooctanoic acid (PFOA) is an abundant perfluoroalkyl substance widely applied in industrial and consumer products. Among its potential health hazards, testicular toxicity is of major concern. To explore the potential effect of miRNA on post-translational regulation after PFOA exposure, changes in miRNAs were detected via miRNA array. Seventeen miRNAs were differentially expressed (eight upregulated, nine downregulated) in male mouse testes after exposure to 5mg/kg/d of PFOA for 28d (>1.5-fold and P<0...
March 1, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28123080/cortactin-is-a-regulator-of-activity-dependent-synaptic-plasticity-controlled-by-wingless
#4
Daniel Alicea, Marizabeth Perez, Carolina Maldonado, Carihann Dominicci-Cotto, Bruno Marie
: Major signaling molecules initially characterized as key early developmental regulators are also essential for the plasticity of the nervous system. Recently the Wingless (Wg)/Wnt pathway has been shown to underlie the structural and electrophysiological changes during activity-dependent synaptic plasticity at the Drosophila neuromuscular junction. A challenge remains to understand how this signal mediates the cellular changes underlying this plasticity. Here, we focus on the actin regulator Cortactin, a major organizer of protrusion, membrane mobility and invasiveness, and define its new role in synaptic plasticity...
January 25, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28122813/hs1-deficiency-impairs-neutrophil-recruitment-in-vivo-and-activation-of-the-small-gtpases-rac1-and-rap1
#5
Joanna Latasiewicz, Annette Artz, Ding Jing, Mariana Pacheco Blanco, Silke M Currie, Martha Velázquez Avila, Michael Schnoor, Dietmar Vestweber
Neutrophil extravasation is a critical step of the innate immune system's response to inflammation. This multistep process is tightly regulated by adhesion and signaling molecules in the endothelium and neutrophils. Activation of the β2 integrin LFA-1 is critical for adhesion of leukocytes to postcapillary venules. This step requires coordinated activation of signaling pathways in chemokine-stimulated neutrophils, including GTPase activation and cytoskeletal remodeling, leading to conformational changes in LFA-1...
January 25, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28120846/cortactin-deficiency-causes-increased-rhoa-rock1-dependent-actomyosin-contractility-intestinal-epithelial-barrier-dysfunction-and-disproportionately-severe-dss-induced-colitis
#6
A F Citalán-Madrid, H Vargas-Robles, A García-Ponce, M Shibayama, A Betanzos, P Nava, C Salinas-Lara, K Rottner, R Mennigen, M Schnoor
The intestinal epithelium constitutes a first line of defense of the innate immune system. Epithelial dysfunction is a hallmark of intestinal disorders such as inflammatory bowel diseases (IBDs). The actin cytoskeleton controls epithelial barrier integrity but the function of actin regulators such as cortactin is poorly understood. Given that cortactin controls endothelial permeability, we hypothesized that cortactin is also important for epithelial barrier regulation. We found increased permeability in the colon of cortactin-KO mice that was accompanied by reduced levels of ZO-1, claudin-1, and E-cadherin...
January 25, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/28115390/inhibition-of-klf5-myo9b-rhoa-pathway-mediated-podosome-formation-in-macrophages-ameliorates-abdominal-aortic-aneurysm
#7
Dong Ma, Bin Zheng, Toru Suzuki, Ruonan Zhang, Chunyang Jiang, Disi Bai, Weina Yin, Zhan Yang, Xinhua Zhang, Lianguo Hou, Hong Zhan, Jin-Kun Wen
RATIONALE: Abdominal aortic aneurysms (AAAs) are characterized by pathological remodeling of the aortic wall. Although both increased Krüppel-like factor 5 (KLF5) expression and macrophage infiltration have been implicated in vascular remodeling, the role of KLF5 in macrophage infiltration and AAA formation remains unclear. OBJECTIVE: To determine the role of KLF5 in AAA formation and macrophage infiltration into AAAs. METHODS AND RESULTS: KLF5 expression was significantly increased in human AAA tissues and in two mouse models of experimental AAA...
January 23, 2017: Circulation Research
https://www.readbyqxmd.com/read/28068324/role-of-akt2-in-regulation-of-metastasis-suppressor-1-expression-and-colorectal-cancer-metastasis
#8
E Agarwal, C M Robb, L M Smith, M G Brattain, J Wang, J D Black, S Chowdhury
Survival signaling is critical for the metastatic program of cancer cells. The current study investigated the role of Akt survival proteins in colorectal cancer (CRC) metastasis and explored potential mechanisms of Akt-mediated metastasis regulation. Using an orthotopic implantation model in mice, which uniquely recapitulates the entire multistep process of CRC metastasis, combined with an inducible system of short hairpin RNA-mediated Akt isoform knockdown in human CRC cells, our studies confirm a role of Akt2 in CRC cell dissemination to distant organs in vivo...
January 9, 2017: Oncogene
https://www.readbyqxmd.com/read/28052035/brca1-iris-overexpression-promotes-and-maintains-the-tumor-initiating-phenotype-implications-for-triple-negative-breast-cancer-early-lesions
#9
Abhilasha Sinha, Bibbin T Paul, Lisa M Sullivan, Hillary Sims, Ahmed El Bastawisy, Hend F Yousef, Abdel-Rahman N Zekri, Abeer A Bahnassy, Wael M ElShamy
Tumor-initiating cells (TICs) are cancer cells endowed with self-renewal, multi-lineage differentiation, increased chemo-resistance, and in breast cancers the CD44+/CD24-/ALDH1+ phenotype. Triple negative breast cancers show lack of BRCA1 expression in addition to enhanced basal, epithelial-to-mesenchymal transition (EMT), and TIC phenotypes. BRCA1-IRIS (hereafter IRIS) is an oncogene produced by the alternative usage of the BRCA1 locus. IRIS is involved in induction of replication, transcription of selected oncogenes, and promoting breast cancer cells aggressiveness...
December 29, 2016: Oncotarget
https://www.readbyqxmd.com/read/28006832/the-dual-edema-preventing-molecular-mechanism-of-the-crataegus-extract-ws-1442-can-be-assigned-to-distinct-phytochemical-fractions
#10
Simone Fuchs, Iris Bischoff, Elisabeth A Willer, Jacqueline Bräutigam, Martin F Bubik, Clemens A J Erdelmeier, Egon Koch, Maria T Faleschini, Maria De Mieri, Milena Bauhart, Stefan Zahler, Andreas Hensel, Matthias Hamburger, Olivier Potterat, Robert Fürst
The hawthorn (Crataegus spp.) extract WS 1442 is used against mild forms of chronic heart failure. This disease is associated with endothelial barrier dysfunction and edema formation. We have recently shown that WS 1442 protects against this dysfunction by a dual mechanism: it both promotes endothelial barrier integrity by activation of a barrier-enhancing pathway (cortactin activation) and inhibits endothelial hyperpermeability by blocking a barrier disruptive pathway (calcium signaling). In this study, we aimed to identify the bioactive compounds responsible for these actions by using a bioactivity-guided fractionation approach...
December 22, 2016: Planta Medica
https://www.readbyqxmd.com/read/27974247/annexin-a2-is-critical-for-blood-testis-barrier-integrity-and-spermatid-disengagement-in-the-mammalian-testis
#11
Katarzyna Chojnacka, Barbara Bilinska, Dolores D Mruk
Throughout spermatogenesis, two important processes occur at late stage VIII of the seminiferous epithelial cycle in the rat testis: preleptotene spermatocytes commence entry into the adluminal compartment and step 19 spermatids release from the seminiferous epithelium. Presently, it is not clear how these processes, which involve extensive restructuring of unique Sertoli-Sertoli and Sertoli-germ cell junctions, are mediated. We aimed to determine whether annexin A2 (ANXA2), a Ca(2+)-dependent and phospholipid-binding protein, participates in cell junction dynamics...
December 11, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27959772/cellular-defense-or-viral-assist-the-dilemma-of-hdac6
#12
Kai Zheng, Yingchun Jiang, Zhendan He, Kaio Kitazato, Yifei Wang
AbstractHistone deacetylase 6 (HDAC6) is an unique cytoplasmic deacetylase that regulates various important biological processes via preventing protein aggregation and deacetylating different non-histone substrates including tubulin, heat shock protein 90 (Hsp90), cortactin, retinoic acid inducible gene I (RIG-1) and β-catenin. Growing evidences have indicated a dual role for HDAC6 in viral infection and pathogenesis: HDAC6 may represent a host defense mechanism against viral infection through modulating microtubule, triggering antiviral immune response and stimulating protective autophagy, or it may be hijacked by the virus to enhance proinflammatory response...
December 12, 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27911942/persistent-morbillivirus-infection-leads-to-altered-cortactin-distribution-in-histiocytic-sarcoma-cells-with-decreased-cellular-migration-capacity
#13
Vanessa Maria Pfankuche, Mohamed Sayed-Ahmed, Vanessa Bono Contioso, Ingo Spitzbarth, Karl Rohn, Reiner Ulrich, Ulrich Deschl, Arno Kalkuhl, Wolfgang Baumgärtner, Christina Puff
Histiocytic sarcomas represent rare but fatal neoplasms in humans. Based on the absence of a commercially available human histiocytic sarcoma cell line the frequently affected dog displays a suitable translational model. Canine distemper virus, closely related to measles virus, is a highly promising candidate for oncolytic virotherapy. Therapeutic failures in patients are mostly associated with tumour invasion and metastasis often induced by misdirected cytoskeletal protein activities. Thus, the impact of persistent canine distemper virus infection on the cytoskeletal protein cortactin, which is frequently overexpressed in human cancers with poor prognosis, was investigated in vitro in a canine histiocytic sarcoma cell line (DH82)...
2016: PloS One
https://www.readbyqxmd.com/read/27903975/cortactin-promotes-colorectal-cancer-cell-proliferation-by-activating-the-egfr-mapk-pathway
#14
Xiaojian Zhang, Kun Liu, Tao Zhang, Zhenlei Wang, Xuan Qin, Xiaoqian Jing, Haoxuan Wu, Xiaopin Ji, Yonggang He, Ren Zhao
Cortactin (CTTN) is overexpressed in various tumors, including head and neck squamous cell carcinoma and colorectal cancer (CRC), and can serve as a biomarker of cancer metastasis. We observed that CTTN promotes cancer cell proliferation in vitro and increases CRC tumor xenograft growth in vivo. CTTN expression increases EGFR protein levels and enhances the activation of the MAPK signaling pathway. CTTN expression also inhibits the ubiquitin-mediated degradation of EGFR by suppressing the coupling of c-Cbl with EGFR...
January 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/27893827/astrocyte-structural-and-molecular-response-to-elevated-intraocular-pressure-occurs-rapidly-and-precedes-axonal-tubulin-rearrangement-within-the-optic-nerve-head-in-a-rat-model
#15
Shandiz Tehrani, Lauren Davis, William O Cepurna, Tiffany E Choe, Diana C Lozano, Ashley Monfared, Lauren Cooper, Joshua Cheng, Elaine C Johnson, John C Morrison
Glaucomatous axon injury occurs at the level of the optic nerve head (ONH) in response to uncontrolled intraocular pressure (IOP). The temporal response of ONH astrocytes (glial cells responsible for axonal support) to elevated IOP remains unknown. Here, we evaluate the response of actin-based astrocyte extensions and integrin-based signaling within the ONH to 8 hours of IOP elevation in a rat model. IOP elevation of 60 mm Hg was achieved under isoflurane anesthesia using anterior chamber cannulation connected to a saline reservoir...
2016: PloS One
https://www.readbyqxmd.com/read/27879274/cortactin-in-atherosclerosis-just-say-no
#16
EDITORIAL
Patrick Belvitch, Alicia N Rizzo, Steven M Dudek
No abstract text is available yet for this article.
December 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/27864464/inhibition-of-stress-fiber-formation-preserves-blood-brain-barrier-after-intracerebral-hemorrhage-in-mice
#17
Anatol Manaenko, Peng Yang, Derek Nowrangi, Enkhjargal Budbazar, Richard E Hartman, Andre Obenaus, William J Pearce, John H Zhang, Jiping Tang
*Anatol Manaenko and Peng Yang contributed equally to this work.Intracerebral hemorrhage (ICH) represents the deadliest subtype of all strokes. The development of brain edema, a consequence of blood-brain barrier (BBB) disruption, is the most life-threatening event after ICH. Pathophysiological conditions activate the endothelium, one of the components of BBB, inducing rearrangement of the actin cytoskeleton. Upon activation, globular actin assembles into a filamentous actin resulting in the formation of contractile actin bundles, stress fibers...
November 18, 2016: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/27864331/role-of-sphingosine-kinase-1-and-s1p-transporter-spns2-in-hgf-mediated-lamellipodia-formation-in-lung-endothelium
#18
Panfeng Fu, David L Ebenezer, Evgeny V Berdyshev, Irina A Bronova, Mark Shaaya, Anantha Harijith, Viswanathan Natarajan
Hepatocyte growth factor (HGF) signaling via c-Met is known to promote endothelial cell motility and angiogenesis. We have previously reported that HGF stimulates lamellipodia formation and motility of human lung microvascular endothelial cells (HLMVECs) via PI3K/Akt signal transduction and reactive oxygen species generation. Here, we report a role for HGF-induced intracellular sphingosine-1-phosphate (S1P) generation catalyzed by sphingosine kinase 1 (SphK1), S1P transporter, spinster homolog 2 (Spns2), and S1P receptor, S1P1, in lamellipodia formation and perhaps motility of HLMVECs...
December 30, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27825967/a-novel-splice-variant-of-supervillin-sv5-promotes-carcinoma-cell-proliferation-and-cell-migration
#19
Xueran Chen, Haoran Yang, Shangrong Zhang, Zhen Wang, Fang Ye, Chaozhao Liang, Hongzhi Wang, Zhiyou Fang
Supervillin is an actin-associated protein that regulates actin dynamics by interacting with Myosin II, F-actin, and Cortactin to promote cell contractility and cell motility. Two splicing variants of human Supervillin (SV1 and SV4) have been reported in non-muscle cells; SV1 lacks 3 exons present in the larger isoform SV4. SV2, also called archvillin, is present in striated muscle; SV3, also called smooth muscle archvillin or SmAV, was cloned from smooth muscle. In the present study, we identify a novel splicing variant of Supervillin (SV5)...
January 1, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27824079/mena-inv-dysregulates-cortactin-phosphorylation-to-promote-invadopodium-maturation
#20
Maxwell D Weidmann, Chinmay R Surve, Robert J Eddy, Xiaoming Chen, Frank B Gertler, Ved P Sharma, John S Condeelis
Invadopodia, actin-based protrusions of invasive carcinoma cells that focally activate extracellular matrix-degrading proteases, are essential for the migration and intravasation of tumor cells during dissemination from the primary tumor. We have previously shown that cortactin phosphorylation at tyrosine residues, in particular tyrosine 421, promotes actin polymerization at newly-forming invadopodia, promoting their maturation to matrix-degrading structures. However, the mechanism by which cells regulate the cortactin tyrosine phosphorylation-dephosphorylation cycle at invadopodia is unknown...
November 8, 2016: Scientific Reports
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