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Perioperative probiotics

Minoru Mizuta, Izuru Endo, Sumiharu Yamamoto, Hidetoshi Inokawa, Masatoshi Kubo, Tetsunobu Udaka, Osanori Sogabe, Hiroya Maeda, Kazutoyo Shirakawa, Eriko Okazaki, Toshitaka Odamaki, Fumiaki Abe, Jin-Zhong Xiao
The use of probiotics has been widely documented to benefit human health, but their clinical value in surgical patients remains unclear. The present study investigated the effect of perioperative oral administration of probiotic bifidobacteria to patients undergoing colorectal surgery. Sixty patients undergoing colorectal resection were randomized to two groups prior to resection. One group (n=31) received a probiotic supplement, Bifidobacterium longum BB536, preoperatively for 7-14 days and postoperatively for 14 days, while the other group (n=29) received no intervention as a control...
2016: Bioscience of Microbiota, Food and Health
Zhiping Yang, Qiong Wu, Yunfang Liu, Daiming Fan
BACKGROUND: Bacterial infection following gastrointestinal surgery remains a common morbidity. The aim of this study was to estimate the effect of the perioperative use of probiotics and synbiotics on postoperative infections. MATERIALS AND METHODS: We searched PubMed, Embase, and the Cochrane Library to identify pertinent randomized controlled trials (RCTs). The primary outcome was postoperative infection rate. The secondary outcomes were length of hospital and intensive care unit (ICU) stay, length of antibiotic therapy, and mortality...
February 10, 2016: JPEN. Journal of Parenteral and Enteral Nutrition
Tadaharu Okazaki, Takashi Asahara, Atsuyuki Yamataka, Yuki Ogasawara, Geoffrey J Lane, Koji Nomoto, Satoru Nagata, Yuichiro Yamashiro
The efficacy of perioperative probiotic administration has been reported in adults. We examined the effects of orally administered Bifidobacterium breve strain Yakult (BBG-01) on outcomes in pediatric surgical cases by assessing intestinal and blood microbiota. BBG-01 was well tolerated without adverse effects, and postoperative infectious complications were significantly decreased. Fecal analysis showed increased Bifidobacterium and decreased Enterobacteriaceae, Clostridium difficile, and Pseudomonas. Concentrations of fecal acetic acid were significantly increased, maintaining fecal pH at <7...
July 2016: Journal of Pediatric Gastroenterology and Nutrition
Yongzhi Yang, Yang Xia, Hongqi Chen, Leiming Hong, Junlan Feng, Jun Yang, Zhe Yang, Chenzhang Shi, Wen Wu, Renyuan Gao, Qing Wei, Huanlong Qin, Yanlei Ma
This study was designed to mainly evaluate the anti-infective effects of perioperative probiotic treatment in patients receiving confined colorectal cancer (CRC) respective surgery. From November 2011 to September 2012, a total of 60 patients diagnosed with CRC were randomly assigned to receive probiotic (n = 30) or placebo (n = 30) treatment. The operative and post-operative clinical results including intestinal cleanliness, days to first - flatus, defecation, fluid diet, solid diet, duration of pyrexia, average heart rate, length of intraperitoneal drainage, length of antibiotic therapy, blood index changes, rate of infectious and non-infectious complications, postoperative hospital stay, and mortality were investigated...
February 16, 2016: Oncotarget
Naoya Aisu, Shu Tanimura, Yuichi Yamashita, Kanefumi Yamashita, Kenji Maki, Yoichiro Yoshida, Takamitsu Sasaki, Shinsuke Takeno, Seiichiro Hoshino
The aim of the present study was to estimate the effect of the perioperative administration of probiotics in patients undergoing colorectal cancer (CRC) surgery. The study focused on a total of 156 consecutive surgeries carried out from among all the elective CRC surgeries performed between April 2009 and March 2013. The patients involved in surgeries undertaken between April 2009 and October 2011 were placed in the non-probiotic group (group A, 81 patients) and those involved in surgeries between November 2011 and March 2013 were placed in the probiotic group (group B, 75 patients)...
September 2015: Experimental and Therapeutic Medicine
Teresa Hoos, Malissa Warren, Robert G Martindale
As we look forward in 2015, attention to perioperative surgical nutrition continues to play a key role in optimizing outcomes and enhancing surgical recovery. Nutrition therapies for preoperative preparation include high protein intake combined with exercise, immune- and metabolic-modulating nutrients, carbohydrate loading, probiotic therapy and, occasionally, the need for specialized enteral or parenteral nutrition. Early enteral nutrition and probiotic therapy optimize gastrointestinal integrity and function in the postoperative setting...
2015: Nestlé Nutrition Institute Workshop Series
Takako Umenai, Nobuaki Shime, Takashi Asahara, Koji Nomoto, Toshiyuki Itoi
BACKGROUND: Probiotics have currently been widely used in patients undergoing various types of surgeries and improved their clinical outcomes, while data in pediatric cardiac surgery have been lacking. We investigated the safety and effects on the intestinal microbiota of the probiotic Bifidobacterium breve in neonates undergoing surgery for congenital heart disease. METHODS: This pilot, randomized study was performed in a single-center, university hospital-based pediatric intensive care unit (PICU)...
2014: Journal of Intensive Care
Marcella Lobato D Consoli, Raphael Steinberg da Silva, Jacques Robert Nicoli, Oscar Bruña-Romero, Rodrigo Gomes da Silva, Simone de Vasconcelos Generoso, Maria Isabel T D Correia
BACKGROUND: When intestinal microbiota is imbalanced, a patient becomes more vulnerable to infectious complications; intervention with beneficial probiotics may help lower risk for infection. The aim of this study was to measure levels of inflammatory cytokine messenger RNA (mRNA) in surgical samples of intestinal mucosal tissues from patients who were given the probiotic Saccharomyces boulardii before undergoing colon surgery. METHODS: Thirty-three patients undergoing colon resection were randomly assigned to receive at least 7-day preoperative probiotic treatment (n = 15) or conventional (n = 18) treatment...
April 27, 2015: JPEN. Journal of Parenteral and Enteral Nutrition
Zhihua Liu, Chao Li, Meijin Huang, Chao Tong, Xingwei Zhang, Lei Wang, Hui Peng, Ping Lan, Peng Zhang, Nanqi Huang, Junsheng Peng, Xiaojian Wu, Yanxing Luo, Huanlong Qin, Liang Kang, Jianping Wang
BACKGROUND: Colorectal liver metastases (CLM) occur frequently and postoperative intestinal infection is a common complication. Our previous study showed that probiotics could decrease the rate of infectious complications after colectomy for colorectal cancer. To determine the effects of the perioperative administration of probiotics on serum zonulin levels which is a marker of intestinal permeability and the subsequent impact on postoperative infectious complications in patients with CLM...
2015: BMC Gastroenterology
Heloisa Martins Sommacal, Vivian Pierri Bersch, Santo Pascoal Vitola, Alessandro Bersch Osvaldt
Periampullary neoplasms are rapidly progressive tumors with a poor prognosis and high morbidity and mortality rates, which have a negative influence on patient outcomes. Some probiotics and prebiotics have the ability to protect the intestinal barrier and prevent bacterial translocation, infection, and postoperative complications. We evaluated the use of synbiotics in a prospective, double-blind study of patients undergoing surgery for periampullary neoplasms (PNs) and assessed the effect of these agents on nutritional status, postoperative complications, antibiotic use, length of hospital stay, and mortality...
2015: Nutrition and Cancer
Zhi-Hua Liu, Liang Kang, Jian-Ping Wang
Probiotics got protective effects on the intestinal barrier. Our present study is to review the basic and clinical progress on the regulation of the intestinal barrier by Lactobacillus and its active protein components, combing the study of our center. Our study have isolated the active component of micro integral membrane protein (MIMP) within the media place of the integral membrane protein of Lactobacillus plantarum, which was verified about the protective effects against the intestinal epithelial dysfunction...
December 2014: Molecular Biology Reports
Lindsay M Urben, Jennifer Wiedmar, Erica Boettcher, Rodrigo Cavallazzi, Robert G Martindale, Stephen A McClave
Probiotics are living microorganisms which have demonstrated many benefits in prevention, mitigation, and treatment of various disease states in critically ill populations. These diseases include antibiotic-associated diarrhea, Clostridium difficile diarrhea, ventilator-associated pneumonia, clearance of vancomycin-resistant enterococci from the GI tract, pancreatitis, liver transplant, major abdominal surgery, and trauma. However, their use has been severely limited due to a variety of factors including a general naïveté within the physician community, lack of regulation, and safety concerns...
2014: Current Gastroenterology Reports
Sotaro Sadahiro, Toshiyuki Suzuki, Akira Tanaka, Kazutake Okada, Hiroko Kamata, Toru Ozaki, Yasuhiro Koga
BACKGROUND: We have already reported that, for patients undergoing elective colon cancer operations, perioperative infection can be prevented by a single intravenous dose of an antibiotic given immediately beforehand if mechanical bowel preparation and the administration of oral antibiotics are implemented. Synbiotics has been reported to reduce the rate of infection in patients after pancreatic cancer operations. The effectiveness of oral antibiotics and probiotics in preventing postoperative infection in elective colon cancer procedures was examined in a randomized controlled trial...
March 2014: Surgery
Gianluca Pellino, Guido Sciaudone, Giuseppe Candilio, Antonio Camerlingo, Rosa Marcellinaro, Serena De Fatico, Federica Rocco, Silvestro Canonico, Gabriele Riegler, Francesco Selvaggi
BACKGROUND: Perioperative prophylactic antibiotic treatment significantly influences intestinal microflora, resulting in impaired bowel functioning in some patients, sometimes requiring further investigations. This may lead to a worse health-related quality of life (HRQoL). Probiotics administrated in the early post-operative period may help avoiding such nuisances in older people. METHODS: We prospectively enrolled patients undergoing laparoscopic colorectal surgery aged over 70 years between 2005 and 2012...
2013: BMC Surgery
T Miko Enomoto, Dawn Larson, Robert G Martindale
One of the most important factors affecting outcome and recovery from surgical trauma is preoperative nutritional status. Research in perioperative nutritional support has suffered from a lack of consensus as to the definition of malnutrition, no recognition of which nutrients are important to surgical healing, and a paucity of well-designed studies. In the past decade, there has been some activity to address this situation, recognizing the importance of nutrition as a therapy before surgery, after surgery, and possibly even during surgery...
November 2013: Medical Clinics of North America
Kiriaki Peitsidou, Theodoros Karantanos, George E Theodoropoulos
BACKGROUND/AIMS: Pro-/pre-/synbiotics supplementation seems to provide beneficial effects in various aspects of abdominal pathology. Skepticism exists with respect to their effects on colorectal cancer (CRC) patients. This review presents the potential clinical applications of pro-/pre-/synbiotics in CRC surgery. METHODS: A literature search of electronic databases was conducted and all studies published on 'probiotics', 'prebiotics' and 'synbiotics' were collected...
2012: Digestive Surgery
Zhi-Hua Liu, Mei-Jin Huang, Xing-Wei Zhang, Lei Wang, Nan-Qi Huang, Hui Peng, Pin Lan, Jun-Sheng Peng, Zhen Yang, Yang Xia, Wei-Jie Liu, Jun Yang, Huan-Long Qin, Jian-Ping Wang
BACKGROUND: Zonulin is a newly discovered protein that has an important role in the regulation of intestinal permeability. Our previous study showed that probiotics can decrease the rate of infectious complications in patients undergoing colectomy for colorectal cancer. OBJECTIVE: The objective was to determine the effects of the perioperative administration of probiotics on serum zonulin concentrations and the subsequent effect on postoperative infectious complications in patients undergoing colorectal surgery...
January 2013: American Journal of Clinical Nutrition
Dan He, Hai-Yang Wang, Jing-Yan Feng, Ming-Ming Zhang, Yong Zhou, Xiao-Ting Wu
AIMS: To estimate the efficacy of pro-/synbiotics treatment in patients undergoing colorectal resection, a meta-analysis of randomized controlled trials was conducted. METHODS: An electronic search of PubMed, MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, Academic Search Premier, and China National Knowledge Infrastructure was performed, and RevMan 5.0 was used for statistical analysis. RESULTS: Six studies including 361 patients undergoing elective colorectal surgery were retrieved...
September 2013: Clinics and Research in Hepatology and Gastroenterology
Jonathan Cohen, w Dat N Chin
The effect of nutritional support in critically ill patients with sepsis has received much attention in recent years. However, many of the studies have produced conflicting results. As for all critically ill patients, nutritional support, preferably via the enteral route, should be commenced once initial resuscitation and adequate perfusion pressure is achieved. Where enteral feeding is impossible or not tolerated, parenteral nutrition (either as total or complimentary therapy) may safely be administered. Most positive studies relating to nutritional support and sepsis have been in the setting of sepsis prevention...
2013: World Review of Nutrition and Dietetics
Dajian Zhu, Xiaowu Chen, Jinhao Wu, Yongle Ju, Jing Feng, Guangsheng Lu, Manzhao Ouyang, Baojun Ren, Yong Li
OBJECTIVE: To investigate the effect of perioperative application of intestinal probiotics to substitute oral intestinal antimicrobial agents on intestinal flora and immune function in surgical patients with colorectal cancer. METHODS: Sixty patients with colorectal cancer undergoing elective laparoscopic radical surgery were randomized to receive preoperative bowel preparation using oral intestinal antimicrobial agents (n=20) or using oral intestinal probiotics (Jinshuangqi Tablets, 2...
August 2012: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
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