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Perioperative antibiotics

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https://www.readbyqxmd.com/read/29221299/surgical-site-infections-after-lung-resection-a-prospective-study-of-risk-factors-in-1-091-consecutive-patients
#1
Andrea Imperatori, Elisa Nardecchia, Lorenzo Dominioni, Daniele Sambucci, Sebastiano Spampatti, Giancarlo Feliciotti, Nicola Rotolo
Background: To assess incidence and risk factors of surgical site infections (SSI) (wound infection, pneumonia, empyema) in a monocentric series of patients undergoing lung resection over a decade. Methods: All patients undergoing lung resection at our institution in 2006-2015 [wedge resection, n=579; lobectomy, n=472 (12% after chemo/radiotherapy); pneumonectomy, n=40 (47% after chemo/radiotherapy)], were prospectively enrolled. Perioperative SSI risk factors were recorded: age, gender, blood haemoglobin, lymphocyte count, serum albumin, forced expiratory volume in 1 second percentage (FEV1%) of predicted, antibiotic prophylaxis, length of stay, diabetes, malignancy, steroid therapy, induction chemo/radiotherapy, resection in 2006-2010/2011-2015, urgent/elective procedure, videothoracoscopic/open approach, resection type, operative time...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29210159/safety-of-mtor-inhibitor-continuation-in-pediatric-heart-transplant-recipients-undergoing-surgical-procedures
#2
Ann Heble, Melanie D Everitt, Jane Gralla, Shelley D Miyamoto, Michael Lahart, Jennifer Eshelman
mTOR inhibitors have been associated with SWC when used in the perioperative period. Limited literature is available to guide providers in managing chronic mTOR inhibitor use in the perioperative period, especially in the pediatric setting. The primary aim of this study was to describe the prevalence of SWC with mTOR inhibitor continuation during the perioperative period for major surgeries. Heart transplant recipients ≤25 years old at the time of primary heart transplant receiving sirolimus maintenance therapy during a surgical procedure and within the study period were included...
December 6, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/29204822/the-experience-of-the-ripo-a-shoulder-prosthesis-registry-with-6-year-follow-up
#3
G Porcellini, A Combi, G Merolla, B Bordini, S Stea, G Zanoli, P Paladini
BACKGROUND: Implant registries have proved valuable in assessing the outcomes of arthroplasty procedures. Moreover, by identifying lesser quality implants they have indirectly improved the quality of care. The registry of prosthetic shoulder implants was established in 2008. METHODS: It records information on all types of primary and revision arthroplasty procedures involving the glenohumeral joint, including reverse and total arthroplasty, hemiarthroplasty, resurfacing, removal, and any other surgical procedures that are required to manage these patients...
December 4, 2017: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/29203481/concentrations-of-cefuroxime-in-brain-tissue-of-neurointensive-care-patients
#4
A Hosmann, L C Ritscher, H Burgmann, Z Oesterreicher, W Jäger, S Poschner, E Knosp, A Reinprecht, A Gruber, M Zeitlinger
Introduction Effective concentrations of antibiotics in brain tissue are essential for antimicrobial therapy of brain infections. However, data concerning cerebral penetration properties of antibiotics for treatment or prophylaxis of central nervous system infections are rare.Methods Six patients suffering subarachnoid hemorrhage and requiring cerebral microdialysis for neurochemical monitoring were included in this study. Free interstitial concentrations of cefuroxime after intravenous application of 1500 mg were measured by microdialysis in brain tissue as well as in plasma at steady-state (n=6) or after single-dose administration (n=1)...
December 4, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29193942/-perioperative-management-protocol-of-patients-undergoing-microsurgical-flaps-in-main-healthcare-centers
#5
Alejandro Cruz-Segura, Pedro Grajeda-López
Microsurgery is one of the most fertile and innovative area in reconstructive surgery. Today it is considered an indispensable technique in plastic surgery with flaps survival rates over 95% in main healthcare centers. The factors involved in achieving these results are: the improvement of the surgical technique, adequate patient selection and careful perioperative care. Perioperative care starts at the initial assessment of the patient where it's very important to consider the indications and contraindications of these procedures...
September 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29193009/do-perioperative-antibiotics-reduce-the-risk-of-surgical-site-infections-following-excision-of-ulcerated-skin-cancers-a-critically-appraised-topic
#6
S A Chan, A G H Wernham, N Stembridge, N Harper, S Verykiou, G A Fremlin, R A Abbott, R N Matin
AIM: To review the efficacy of perioperative antibiotics in reducing the risk of surgical site infections (SSI) following excision of ulcerated skin cancers. SETTING AND DESIGN: Study selection, data extraction and analysis were carried out independently by four authors. Only randomised controlled trials (RCTs) reported in the English Language were included. INCLUDED STUDIES: Randomised controlled trials (RCTs) in the English language in which patients received perioperative topical, intralesional, or oral antibiotics for dermatological surgery including Mohs micrographic surgery in General Practice, Dermatology or Plastic Surgery Departments were included...
November 28, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29178982/microbiology-and-associated-risk-factors-in-alloplastic-total-joint-infections-a-20-year-retrospective-study
#7
Rhae Riegel, Kevin Sweeney, Gino Inverso, Peter Quinn, Eric J Granquist
PURPOSE: Prosthetic joint infection (PJI) is a rare complication of temporomandibular joint replacement (TJR). This study evaluated TJR PJIs at the authors' institution over a 20-year period, including micro-organisms cultured, antibiotic resistance patterns, and intraoperative protocols of TJR. PATIENTS AND METHODS: Patients were identified using Current Procedural Terminology and International Classification of Diseases, Ninth Revision codes and surgical logs from January 1995 through 2015...
November 8, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29174784/colonization-with-multiresistant-bacteria-impact-on-ventricular-assist-device-patients
#8
Maria Papathanasiou, Julia Pohl, Alexander Rolf Jánosi, Nikolaus Pizanis, Markus Kamler, Tienush Rassaf, Peter Luedike
BACKGROUND: Although the effect of infections with multidrug-resistant bacteria (MDRB) in left ventricular assist device (LVAD) recipients is well characterized, the influence of perioperative colonization on the development of infections in this patient cohort remains unknown. The study evaluated the effect of MDRB colonization on patient outcomes after LVAD implantation. METHODS: We retrospectively analyzed the microbiological screening studies of nasal, throat, wound, and rectal swabs in 82 consecutive patients who received an LVAD at our center between 2010 and 2015...
November 23, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29167293/perioperative-antibiotic-prophylaxis-has-no-effect-on-time-to-positivity-and-proportion-of-positive-samples-a-cohort-study-of-64-cutibacterium-acnes-bone-and-joint-infections
#9
Alexia Anagnostopoulos, Daniel A Bossard, Bruno Ledergerber, Patrick O Zingg, Annelies S Zinkernagel, Christian Gerber, Yvonne Achermann
If a bone or joint infection is suspected, perioperative antibiotic prophylaxis is frequently withheld until the intraoperative microbiological sampling has been performed. This practice builds upon the hypothesis that perioperative antibiotics could render culture results negative and thus impede tailored antibiotic treatment of infections. We aimed to assess the influence of antibiotic prophylaxis within 30 to 60 minutes before surgery on time to positivity of microbiological samples and proportion of positive samples in Cutibacterium acnes bone and joint infections...
November 22, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29159751/septal-and-turbinate-surgery-is-overnight-essential
#10
Ana Sousa Menezes, Joana R Guimarães, Miguel Breda, Vicente Vieira, Luís Dias
INTRODUCTION: The performance of septoplasty and turbinate surgery in an outpatient basis is an increasingly established practice, although is still a controversial topic. METHODS: Retrospective analysis of 227 patients who underwent septoplasty ± inferior and/or middle turbinoplasty. Demographic, clinical, surgical, and anesthetic data were collected. Our primary outcomes were rates of perioperative complications, prolongation of hospital stay (PHS), unexpected hospital revisits (UHR), or readmissions within 30 days of surgery...
November 20, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29120716/cost-comparison-of-commonly-used%C3%A2-postoperative-topical-ophthalmic%C3%A2-antibiotics
#11
Eric L Crowell, Vivek A Koduri, R Scott Groat, David A Lee
PURPOSE: To provide information on the actual fill level and cost of currently available antibiotic drops used perioperatively. DESIGN: Prospective laboratory investigation. SETTING: Robert Cizik Eye Clinic, Houston, Texas USA. METHODS: The following 9 medications were tested: moxifloxacin, gatifloxacin (branded and generic), besifloxacin, levofloxacin, ciprofloxacin, ofloxacin, trimethoprim/polymyxin B, tobramycin, and gentamicin...
October 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29119289/local-antibiotic-decontamination-to-prevent-anastomotic-leakage-short-term-outcome-in-rectal-cancer-surgery
#12
Ulrich Wirth, Susanne Rogers, Kristina Haubensak, Stefan Schopf, Thomas von Ahnen, Hans Martin Schardey
PURPOSE: Anastomotic leakage still presents an issue in rectal cancer surgery with rates of about 11%. As bacteria play a critical role, there is the concept of perioperative local decontamination to prevent anastomotic leakage. METHODS: To ascertain the effectiveness of this treatment, we performed a retrospective analysis on 206 rectal resections with primary anastomosis and routine use of a selective decontamination of the digestive tract (SDD) regimen for local decontamination...
November 8, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29106917/variation-in-prophylactic-antibiotic-use-for-laparoscopic-cholecystectomy-need-for-better-stewardship-in-pediatric-surgery
#13
Kibileri Williams, Lauren Baumann, Fizan Abdullah, Shawn D St Peter, Tolulope A Oyetunji
PURPOSE: The role of prophylactic antibiotics for elective laparoscopic cholecystectomy has been questioned over the last decade. Although gradually being discontinued in the adult population, the practice among pediatric surgeons remains unknown. Our aim was to investigate the use of perioperative antibiotics in children undergoing elective laparoscopic cholecystectomy (LC) for symptomatic cholelithiasis and biliary dyskinesia. METHODS: We retrospectively reviewed the Pediatric Health Information System (PHIS) database for 2015 and selected all patients 18years old or younger who underwent LC for cholelithiasis (without cholecystitis) or biliary dyskinesia...
October 9, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29104154/the-impact-of-operating-room-environment-on-post-operative-central-nervous-system-infection-in-a-resource-limited-neurosurgical-center-in-south-asia
#14
Swathi Chidambaram, Madabushi Chakravarthy Vasudevan, Mani Nathan Nair, Cara Joyce, Anand V Germanwala
OBJECTIVE: Post-operative central nervous system infections (PCNSIs) are serious complications following neurosurgical intervention. This group previously investigated the incidence and causative pathogens of PCNSIs at a resource-limited, neurosurgical center in South Asia. This follow-up study was conducted to analyze differences in PCNSIs at the same institution following only one apparent change: the operating room air filtration system. METHODS: A retrospective study of all neurosurgical cases from December 1, 2013 to March 31, 2016 was performed...
November 2, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29104029/nasolabial-flap-improves-healing-in-medication-related-osteonecrosis-of%C3%A2-the-jaw
#15
Juliana Lemound, Thomas Muecke, Alexander-Nicolai Zeller, Jürgen Lichtenstein, André Eckardt, Nils-Claudius Gellrich
PURPOSE: Medication-related osteonecrosis of the jaw (MRONJ) is an adverse side effect of antiresorptive and antiangiogenic therapeutic agents that is difficult to treat owing to its high relapse rate. The aim of the present study was to determine whether patients with MRONJ treated using decortication and a nasolabial flap compared with those who underwent decortication with mucoperiosteal flaps have better outcomes regarding stable wound closure. MATERIALS AND METHODS: Two groups of patients with MRONJ and intraoral exposed bone were evaluated in a cohort clinical study retrospectively...
October 13, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29102076/prevention-of-surgical-site-infection-analysis-and-narrative-review-of-clinical-practice-guidelines
#16
Francisco Javier Gómez-Romero, Maria Fernández-Prada, Juan Francisco Navarro-Gracia
Surgical site infection is one of the most prevalent healthcare-associated infections and presents a considerable morbidity. The aim of this comprehensive narrative review is to describe the evidence and grade of recommendation of the preventive measures developed in the three phases of the surgical process (preoperative, perioperative and postoperative phases), as well as coincidences and divergences between selected Clinical Practice Guidelines (CPG). Four preventive measures were recommended with similar high grade evidence in all CPG: Hair removal, antibiotic prophylaxis, surgical site preparation and normothermia...
November 2017: Cirugía Española
https://www.readbyqxmd.com/read/29094328/incidence-of-endophthalmitis-and-the-perioperative-practices-of-cataract-surgery-in-japan-japanese-prospective-multicenter-study-for-postoperative-endophthalmitis-after-cataract-surgery
#17
Tomoyuki Inoue, Toshihiko Uno, Norio Usui, Shinichiro Kobayakawa, Kiyoshi Ichihara, Yuichi Ohashi
PURPOSE: To prospectively survey the incidence of endophthalmitis following cataract surgery and investigate the current perioperative practices in Japan. METHODS: Patients who underwent cataract surgery from January 2012 to December 2013 were included. Information on perioperative practices were recorded prospectively. Clinical characteristics were examined in cases with endophthalmitis. RESULTS: A total of 63,244 patients who underwent cataract surgery in 205 facilities were enrolled...
November 1, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29089731/to-compare-the-effectiveness-of-short-term-three-dose-perioperative-antibiotic-coverage-during-decisive-period-with-conventional-prolonged-postoperative-antibiotic-usage-in-clean-elective-surgical-cases-an-indian-perspective
#18
Sudhir Khichy, Baldev Singh, Manpreet Singh, Sukha Singh
BACKGROUND: Surgical site infections are the most common postoperative complications and frequently cause morbidity and mortality. Different antibiotic regimens were evaluated as prophylaxis in wound infection following elective surgical procedures. Prophylactic antibiotics should be given to cover the "decisive period" which is a period after incision to mobilization of host defenses thus preventing an infection from developing. OBJECTIVES: The aim is to study the effectiveness of short-term antibiotic coverage during decisive period in the prevention of postoperative wound sepsis in clean surgical cases...
July 2017: Nigerian Journal of Surgery: Official Publication of the Nigerian Surgical Research Society
https://www.readbyqxmd.com/read/29066231/antibiotic-prophylaxis-and-infection-prevention-for-endoscopic-endonasal-skull-base-surgery-our-protocol-results-and-review-of-the-literature
#19
Stephen J Johans, Daniel J Burkett, Kevin N Swong, Chirag R Patel, Anand V Germanwala
Endoscopic endonasal approaches to the skull base provide minimally invasive corridors to intracranial lesions; however, enthusiasm for this new approach is always tempered by the recognition that this route requires passage through a nonsterile sinonasal corridor. Despite an increasing number of patients undergoing these surgeries, there remains no consensus on the use of perioperative antibiotics. A retrospective review of consecutive patients undergoing endoscopic endonasal skull base surgery (EESBS) at Loyola University Medical Center by the same neurosurgeon and otolaryngologist team between February 2015 and October 2016 was performed...
October 21, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29051981/preoperative-optimization-of-patients-with-inflammatory-bowel-disease-undergoing-gastrointestinal-surgery-a-systematic-review
#20
REVIEW
Marie Strøm Zangenberg, Nir Horesh, Uri Kopylov, Alaa El-Hussuna
PURPOSE: Surgical management of inflammatory bowel disease (IBD) is a challenging task. The aim of preoperative optimization (PO) is to decrease the risk of complications and reduce the length of postoperative stay. The aim of this study was to review and grade the available evidence, attain clear recommendations, and point out potential future research. METHODS: Studies were identified from electronic databases (PubMed, Embase, and Cochrane Library) and scanning reference lists in relevant papers...
December 2017: International Journal of Colorectal Disease
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