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https://www.readbyqxmd.com/read/28339297/long-term-effect-of-panretinal-photocoagulation-on-spectral-domain-optical-coherence-tomography-measurements-in-diabetic-retinopathy
#1
Haeng-Jin Lee, Tae-Seen Kang, Baek-Soo Kwak, Young-Joon Jo, Jung-Yeul Kim
PURPOSE: To evaluate the effects of panretinal photocoagulation on spectral domain optical coherence tomography measurements in diabetic retinopathy by comparing the thicknesses of the central macula, retinal nerve fiber layer, and ganglion cell layer, we used a Cirrus HD OCT® (Carl Zeiss Meditec, Dublin, CA, USA) in normal and diabetic retinopathy cohorts. METHODS: We analyzed patients who visited our retinal clinic between May 2013 and July 2014. The patients were classified into four groups: normal (Group A), diabetes without diabetic retinopathy (Group B), severe nonproliferative or proliferative diabetic retinopathy (Group C), and at least 3 years after panretinal photocoagulation treatment (Group D)...
March 24, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28339057/gpr143-mutations-in-chinese-patients-with-ocular-albinism-type-1
#2
Xiuhua Jia, Jin Yuan, Xiaoyun Jia, Shiqi Ling, Shiqiang Li, Xiangming Guo
The aim of the present study was to evaluate mutations of the G protein-coupled receptor 143 (GPR143) gene for ocular albinism type 1 (OA1) in Chinese patients. For the current study, 8 patients with OA1 were selected from the database of ocular genetic diseases. Genomic DNA of OA1 was prepared from venous leukocytes collected from the patients. Cycle sequencing was used to analyze the exons and adjacent introns of GPR143. The variation detected was analyzed by bidirectional DNA sequencing and further evaluated in 96 controls using heteroduplex‑single strand conformational polymorphism analysis...
March 23, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28338556/adult-onset-foveomacular-vitelliform-dystrophy-evaluated-by-means-of-optical-coherence-tomography-angiography-a-comparison-with-dry-age-related-macular-degeneration-and-healthy-eyes
#3
Lisa Toto, Enrico Borrelli, Rodolfo Mastropasqua, Luca Di Antonio, Peter A Mattei, Paolo Carpineto, Leonardo Mastropasqua
PURPOSE: To investigate alterations of superficial and deep retinal vascular densities, as well as of choroidal thickness, in patients affected by adult-onset foveomacular vitelliform dystrophy (AOFVD). METHODS: A total of 22 eyes (15 patients) affected by AOFVD were recruited in the study. Furthermore, 20 eyes of 20 healthy subjects and 20 eyes of 18 patients affected by intermediate dry age-related macular degeneration (AMD) were enrolled. All patients underwent a complete ophthalmologic examination, including optical coherence tomography angiography...
March 23, 2017: Retina
https://www.readbyqxmd.com/read/28337060/nutraceuticals-in-prevention-of-cataract-an-evidence-based-approach
#4
REVIEW
Amandeep Kaur, Vikas Gupta, Ajay Francis Christopher, Manzoor Ahmad Malik, Parveen Bansal
Cataract is a principal cause of blindness in the world and is characterized by clouding of eye's natural lens. Surgery is the major therapeutic step taken to cure cataract; however, it is having its own limitations and complications such as iris prolapse, raised IOP, infection, cystoid macular edema and posterior capsular opacification (PCO). So world is looking toward more robust and natural ways to prevent cataract. One of the important factors that can play a role in prevention of any and many diseases is diet of the people...
January 2017: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/28336272/apigenin-7-diglucuronide-protects-retinas-against-bright-light-induced-photoreceptor-degeneration-through-the-inhibition-of-retinal-oxidative-stress-and-inflammation
#5
Minjuan Bian, Yong Zhang, Xiaoye Du, Jing Xu, Jingang Cui, Jiangping Gu, Weiliang Zhu, Teng Zhang, Yu Chen
Vision impairment in retinal degenerative diseases such as age-related macular degeneration is primarily associated with photoreceptor degeneration, in which oxidative stress and inflammatory responses are mechanistically involved as central players. Therapies with photoreceptor protective properties remain to be developed. Apigenin-7-diglucuronide (A7DG), a flavonoid glycoside, is present in an assortment of medicinal plants with anti-inflammatory or ant-oxidant activities. However, the pharmacological significance of A7DG remains unknown in vivo...
March 20, 2017: Brain Research
https://www.readbyqxmd.com/read/28336262/increased-susceptibility-to-fundus-camera-delivered-light-induced-retinal-degeneration-in-mice-deficient-in-oxidative-stress-response-proteins
#6
Yi Ding, Bogale Aredo, Xin Zhong, Cynthia X Zhao, Rafael L Ufret-Vincenty
Oxidative stress is an important contributor to the pathogenesis of many retinal diseases including age-related macular degeneration and retinal dystrophies. Light-induced retinal degeneration (LIRD) can serve as a model in which to study the response of the retina to stress. Of note, many genetic mutant mice are in a C57BL/6 J background and are thus resistant to the usual LIRD models. We recently developed a new model of fundus camera-delivered light-induced retinal degeneration (FCD-LIRD) which is effective in strains of mice expressing the light-resistant variant of RPE65 (450Met), including C57BL/6 J...
March 20, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28336128/retinal-pigment-epithelium-tears-classification-pathogenesis-predictors-and-management
#7
REVIEW
Mehmet Giray Ersoz, Murat Karacorlu, Serra Arf, Isil Sayman Muslubas, Mumin Hocaoglu
Various eye conditions cause tears in the retinal pigment epithelium (RPE). The most common cause of an RPE tear is vascularized retinal pigment epithelial detachment (PED) in patients with exudative age-related macular degeneration. Although RPE tears can develop spontaneously in vascularized PEDs, most recent cases have been associated with anti-vascular endothelial growth factor (VEGF) injections. The subretinal fluid within the PED applies hydrostatic pressure to the RPE and stretches it. The PED enlarges as the hydrostatic pressure increases...
March 20, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28334846/dapl1-a-susceptibility-locus-for-age-related-macular-degeneration-acts-as-a-novel-suppressor-of-cell-proliferation-in-the-retinal-pigment-epithelium
#8
Xiaoyin Ma, Huirong Li, Yipin Wang, Jing Wang, Qinxiang Zheng, Jiajia Hua, Juan Yang, Li Pan, Fan Lu, Jia Qu, Ling Hou
The retinal pigment epithelium (RPE) forms a monolayer at the back of the vertebrate eye and is fundamental to retinal function and homoeostasis. During early development, RPE cells undergo rapid proliferation, but in the adult, they remain normally nonproliferative throughout life. Nevertheless, under pathological conditions such as in proliferative vitreoretinopathy or after retinal ablation, mature RPE cells can re-enter the cell cycle and form nodules or multiple cell layers. Here we show that Dapl1, whose human homolog represents a susceptibility locus for age-related macular degeneration (AMD), is highly up-regulated in quiescent but not proliferating RPE cells and that experimental overexpression of DAPL1 in proliferating RPE cells inhibits their proliferation...
February 22, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28333647/automatic-choroidal-layer-segmentation-using-markov-random-field-and-level-set-method
#9
Chuang Wang, Yongmin Li, Ya Xing Wang
The choroid is an important vascular layer that supplies oxygen and nourishment to the retina. The changes in thickness of the choroid have been hypothesised to relate to a number of retinal diseases in the pathophysiology. In this work, an automatic method is proposed for segmenting the choroidal layer from macular images by using the level set framework. The 3D nonlinear anisotropic diffusion filter is used to remove all the OCT imaging artifacts including the speckle noise and to enhance the contrast. The distance regularisation and edge constraint terms are embedded into the level set method to avoid the irregular and small regions and keep information about the boundary between the choroid and sclera...
March 20, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28333572/new-insights-on-complement-inhibitor-cd59-in-mouse-laser-induced-choroidal-neovascularization-mislocalization-after-injury-and-targeted-delivery-for-protein-replacement
#10
Gloriane Schnabolk, Mee Keong Beon, Stephen Tomlinson, Bärbel Rohrer
PURPOSE: The membrane attack complex (MAC) in choriocapillaris (CC) and retinal pigment epithelium (RPE) increase with age and disease (age-related macular degeneration). MAC assembly can be inhibited by CD59, a membrane-bound regulator. Here we further investigated the role of CD59 in murine choroidal neovascularization (CNV), a model involving both CC and RPE, and tested whether CR2-CD59, a soluble targeted form of CD59, provides protection. METHODS: Laser-induced CNV was generated in wild type and CD59a-deficient mice (CD59(-/-))...
March 23, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28330678/acute-macular-edema-and-peripapillary-soft-exudate-after-pancreas-transplantation-with-accelerated-progression-of-diabetic-retinopathy
#11
Fang-Yi Tsai, Ling-Ing Lau, An-Fei Li, Shih-Jen Chen, Shin-E Wang, Fenq-Lih Lee, Catherine Jiu-Lin Liu, Yi-Ming Shyr
BACKGROUND: The effect of pancreas transplantation on diabetic retinopathy remains inconclusive. Herein, we report six patients with type 1 diabetes mellitus (DM) who underwent pancreas transplantation and developed acute macular edema and peripapillary soft exudate with rapid progression to proliferative diabetic retinopathy. METHODS: In this retrospective observational study, diabetic patients who underwent pancreas transplantation in a single medical center and developed symptomatic acute macular edema and peripapillary soft exudate within 3 months after the operation were enrolled...
March 18, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/28325166/color-perception-differentiates-alzheimer-s-disease-ad-from-vascular-dementia-vad-patients
#12
N A Arnaoutoglou, M Arnaoutoglou, P Nemtsas, V Costa, S J Baloyannis, K P Ebmeier
BACKGROUND: Alzheimer's Disease (AD) and Vascular Dementia (VaD) are the most common causes of dementia in older people. Both diseases appear to have similar clinical symptoms, such as deficits in attention and executive function, but specific cognitive domains are affected. Current cohort studies have shown a close relationship between αβ deposits and age-related macular degeneration (Johnson et al., 2002; Ratnayaka et al., 2015). Additionally, a close link between the thinning of the retinal nerve fiber (RNFL) and AD patients has been described, while it has been proposed that AD patients suffer from a non-specific type of color blindness (Pache et al...
March 22, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28323678/long-time-outcome-in-patients-treated-with-ranibizumab-for-diabetic-macular-edema-a-4-year-study
#13
David Epstein, Urban Amrén
PURPOSE: To investigate the long-time visual outcome in patients with diabetic macular edema treated with ranibizumab in an ordinary clinical setting. METHODS: One hundred two eyes of 80 patients were followed for 4 years. All patients received a loading dose of 3 monthly ranibizumab 0.5-mg injections. From Month 3 to Month 48, patients received ranibizumab reinjections pro re nata based on disease activity. RESULTS: Excluding deaths, the 4-year visit was completed by 82% of the study eyes...
January 23, 2017: Retina
https://www.readbyqxmd.com/read/28323511/photoreceptor-cell-injury-starts-in-the-initial-stage-of-vogt-koyanagi-harada-disease
#14
Ruilin Zhu, Jing Zhang, Lijun Qiao, Yadi Zhang, Xiaopeng Gu, Liu Yang
PURPOSE: To demonstrate photoreceptor cell injury in Vogt-Koyanagi-Harada (VKH) disease. METHODS: The SD-OCT and FAF tests of 16 patients diagnosed with VKH disease that was followed up from the initial stage to the convalescent stage were reviewed. RESULTS: In the initial stage of VKH disease, there was hyperautofluerescence around the macular edema. In the convalescent stage of VKH disease, loss of photoreceptor and injury of RPE have been detected by OCT scan at the same area, which was corresponded with the abnormalities in FAF...
March 21, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28322199/adrenomedullin-suppresses-vascular-endothelial-growth-factor-induced-vascular-hyperpermeability-and-inflammation-in-retinopathy
#15
Akira Imai, Yuichi Toriyama, Yasuhiro Iesato, Kazutaka Hirabayashi, Takayuki Sakurai, Akiko Kamiyoshi, Yuka Ichikawa-Shindo, Hisaka Kawate, Megumu Tanaka, Tian Liu, Xian Xian, Liuyu Zhai, Kun Dai, Keiya Tanimura, Teng Liu, Nanqi Cui, Akihiro Yamauchi, Toshinori Murata, Takayuki Shindo
Diabetic macular edema (DME) is caused by blood-retinal barrier breakdown associated with retinal vascular hyperpermeability and inflammation, and it is the major cause of visual dysfunction in diabetic retinopathy. Adrenomedullin (ADM) is an endogenous peptide first identified as a strong vasodilator. ADM is expressed in the eyes and is up-regulated in various eye diseases, although the pathophysiological significance is largely unknown. We investigated the effect of ADM on DME. In Kimba mice, which overexpress human vascular endothelial growth factor in their retinas, the capillary dropout, vascular leakage, and vascular fragility characteristic of diabetic retinopathy were observed, and these changes were accompanied by retinal inflammation...
March 16, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28318640/the-prevalence-of-diabetic-retinopathy-in-australian-adults-with-self-reported-diabetes-the-national-eye-health-survey
#16
Stuart Keel, Jing Xie, Joshua Foreman, Peter van Wijngaarden, Hugh R Taylor, Mohamed Dirani
PURPOSE: To determine the prevalence of and factors associated with diabetic retinopathy (DR) among non-Indigenous and Indigenous Australian adults with self-reported diabetes. DESIGN: Population-based cross-sectional study. PARTICIPANTS: Non-Indigenous Australians (50-98 years of age) and Indigenous Australians (40-92 years of age) with known diabetes. METHODS: Diabetes was determined based on self-report of previous diagnosis of the disease...
March 15, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28318349/visual-morbidity-and-ocular-complications-in-presumed-intraocular-tuberculosis-an-analysis-of-354-cases-from-a-non-endemic-population
#17
Dinesh Visva Gunasekeran, Bhaskar Gupta, Joao Cardoso, Carlos E Pavesio, Rupesh Agrawal
PURPOSE: To describe the visual morbidity associated with intraocular tuberculosis (TB) and to report ocular complications of intraocular TB. METHODS: Retrospective cohort study of patients diagnosed with intraocular TB at a tertiary referral eye care hospital in central London. Data on baseline and final best-corrected visual acuity (BCVA) along with ocular complications were collected and analyzed. RESULTS: In total, 354 patients with intraocular TB were included in this study...
March 20, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28316876/automated-brightness-and-contrast-adjustment-of-color-fundus-photographs-for-the-grading-of-age-related-macular-degeneration
#18
Edem Tsikata, Inês Laíns, João Gil, Marco Marques, Kelsey Brown, Tânia Mesquita, Pedro Melo, Maria da Luz Cachulo, Ivana K Kim, Demetrios Vavvas, Joaquim N Murta, John B Miller, Rufino Silva, Joan W Miller, Teresa C Chen, Deeba Husain
PURPOSE: The purpose of this study was to develop an algorithm to automatically standardize the brightness, contrast, and color balance of digital color fundus photographs used to grade AMD and to validate this algorithm by determining the effects of the standardization on image quality and disease grading. METHODS: Seven-field color photographs of patients (>50 years) with any stage of AMD and a control group were acquired at two study sites, with either the Topcon TRC-50DX or Zeiss FF-450 Plus cameras...
March 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/28315291/perspectives-of-stem-cell-based-therapy-for-age-related-retinal-degenerative-diseases
#19
Vladimir Holan, Barbora Hermankova, Jan Kossl
Retinal degenerative diseases, which include age-related macular degeneration, retinitis pigmentosa, diabetic retinopathy and glaucoma, mostly affect the elderly population, and are the most common cause of decreased quality of vision or even blindness. So far, there is no satisfactory treatment protocol to prevent, stop or cure these disorders. A great hope and promise for patients suffering from retinal diseases is represented by stem cell-based therapy which could replace diseased or missing retinal cells, and support regeneration...
March 17, 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28315278/peeking-into-sigma-1-receptor-functions-through-the-retina
#20
Timur A Mavlyutov, Lian-Wang Guo
This review discusses recent advances towards understanding the sigma-1 receptor (S1R) as an endogenous neuro-protective mechanism in the retina , a favorable experimental model system. The exquisite architecture of the mammalian retina features layered and intricately wired neurons supported by non-neuronal cells. Ganglion neurons, photoreceptors , as well as the retinal pigment epithelium, are susceptible to degeneration that leads to major retinal diseases such as glaucoma , diabetic retinopathy , and age-related macular degeneration (AMD), and ultimately, blindness...
2017: Advances in Experimental Medicine and Biology
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