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https://www.readbyqxmd.com/read/28196206/regression-of-iris-metastasis-after-systemic-treatment-with-melanoma-targeted-therapy
#1
Cristina Fonseca, Júlia Fernandes, Rui Proença
No abstract text is available yet for this article.
February 9, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28180043/preoperative-protective-endovascular-covered-stent-placement-followed-by-surgery-for-management-of-the-cervical-common-and-internal-carotid-arteries-with-tumor-encasement
#2
Michael R Markiewicz, Phillip Pirgousis, Curtis Bryant, James C Cunningham, Roi Dagan, Sukhwinder J Sandhu, Daniel A Siragusa, Arun Gopinath, Rui Fernandes
Objective The objective of this study was to report the outcomes on a preliminary cohort of patients with tumor encasement of either, or both, the cervical internal carotid artery (ICA) and common carotid artery (CCA) following preoperative covered stent placement and surgical resection. Setting This study was set at the University of Florida College of Medicine, Jacksonville, FL. Participants Subjects who received preoperative stenting of the cervical ICA/CCA before surgical resection of head and neck tumors between April 1, 2015, and July 31, 2015 were participated...
February 2017: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/28128745/endothelial-dysfunction-microvascular-damage-and-ischemic-peripheral-vasculopathy-in-systemic-sclerosis
#3
Ivone Fernandes Santos da Silva, Andreia Teixeira, José Oliveira, Rui Almeida, Carlos Vasconcelos
OBJECTIVE: To evaluate endothelial dysfunction and microvascular damage in secondary Raynaud Phenomenon (SRP) and Systemic sclerosis (SSc)-associated patients as possible predictors of ischemic fingertip digital ulcers (DU) in a 3-year clinical follow-up. METHODS: Flow-mediated dilatation (FMD), nailfold videocapillaroscopy (NVC), endothelin-1 (ET-1) and asymmetric dimethylarginine (ADMA) were analysed in a 3-year observational cohort study of 77 SRP patients with systemic sclerosis...
January 27, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28099639/failure-to-activate-the-in-hospital-emergency-team-causes-and-outcomes
#4
Vera Barbosa, Ernestina Gomes, Senio Vaz, Gustavo Azevedo, Gonçalo Fernandes, Amélia Ferreira, Rui Araujo
Objective: To determine the incidence of afferent limb failure of the in-hospital Medical Emergency Team, characterizing it and comparing the mortality between the population experiencing afferent limb failure and the population not experiencing afferent limb failure. Methods: A total of 478 activations of the Medical Emergency Team of Hospital Pedro Hispano occurred from January 2013 to July 2015. A sample of 285 activations was obtained after excluding incomplete records and activations for patients with less than 6 hours of hospitalization...
October 2016: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/28094806/plant-toxin-%C3%AE-odap-activates-integrin-%C3%AE-1-and-focal-adhesion-a-critical-pathway-to-cause-neurolathyrism
#5
Rui-Yue Tan, Geng-Yan Xing, Guang-Ming Zhou, Feng-Min Li, Wen-Tao Hu, Fernand Lambein, Jun-Lan Xiong, Sheng-Xiang Zhang, Hai-Yan Kong, Hao Zhu, Zhi-Xiao Li, You-Cai Xiong
Neurolathyrism is a unique neurodegeneration disease caused by β-N-oxalyl-L-α, β- diaminopropionic (β-ODAP) present in grass pea seed (Lathyrus stativus L.) and its pathogenetic mechanism is unclear. This issue has become a critical restriction to take full advantage of drought-tolerant grass pea as an elite germplasm resource under climate change. We found that, in a human glioma cell line, β-ODAP treatment decreased mitochondrial membrane potential, leading to outside release and overfall of Ca(2+) from mitochondria to cellular matrix...
January 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/27987706/wetspun-poly-l-lactic-acid-borosilicate-bioactive-glass-scaffolds-for-guided-bone-regeneration
#6
João S Fernandes, Rui L Reis, Ricardo A Pires
We developed a porous poly-L-lactic acid (PLLA) scaffold compounded with borosilicate bioactive glasses (BBGs) endowing it with bioactive properties. Porous PLLA-BBG fibre mesh scaffolds were successfully prepared by the combination of wet spinning and fibre bonding techniques. Micro-computed tomography (μCT) confirmed that the PLLA-BBG scaffolds containing ≈25% of BBGs (w/w) exhibited randomly interconnected porous (58 to 62% of interconnectivity and 53 to 67% of porosity) with mean pore diameters higher that 100μm...
February 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27933037/blad-containing-oligomer-fungicidal-activity-on-human-pathogenic-yeasts-from-the-outside-to-the-inside-of-the-target-cell
#7
Ana M Pinheiro, Alexandra Carreira, Filipe Rollo, Rui Fernandes, Ricardo B Ferreira, Sara A Monteiro
Blad polypeptide comprises residues 109-281 of Lupinus albus β-conglutin precursor. It occurs naturally as a major subunit of an edible, 210 kDa oligomer which accumulates to high levels, exclusively in the cotyledons of Lupinus seedlings between the 4th and 14th day after the onset of germination. Blad-containing oligomer (BCO) exhibits a potent and broad spectrum fungicide activity toward plant pathogens and is now on sale in the US under the tradename Fracture(TM). In this work we demonstrate its antifungal activity toward human pathogens and provide some insights on its mode of action...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27905606/a-qm-mm-study-of-the-reaction-mechanism-of-human-%C3%AE-ketoacyl-reductase
#8
Fabiola E Medina, Rui P P Neves, Maria J Ramos, Pedro A Fernandes
Human fatty acid synthase (hFAS) is a multifunctional enzyme involved in a wide diversity of biological functions. For instance, it is a precursor of phospholipids and other complex processes such as the de novo synthesis of long chain fatty acid. Human FAS is also a component of biological membranes and it is implicated in the overexpression of several types of cancers. In this work, we describe the catalytic mechanism of β-ketoreductase (KR), which is a catalytic domain of the hFAS enzyme that catalyzes the reduction of β-ketoacyl to β-hydroxyacyl with the concomitant oxidation of the NADPH cofactor...
December 21, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27888671/sclerosing-polycystic-adenosis-of-the-parotid-gland-a-systematic-review-and-report-of-2-new-cases
#9
Carlos A Espinosa, Laura Rua, Héctor E Torres, Álvaro Fernández Del Valle, Rui P Fernandes, Juan C Devicente
PURPOSE: We sought to evaluate clinical-epidemiologic aspects, pathologic characteristics, and treatment of sclerosing polycystic adenosis (SPA) of the parotid gland and to report 2 new cases. MATERIALS AND METHODS: We conducted a systematic review following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines for studies published in or before June 2016. The inclusion criteria were as follows: final diagnosis of SPA affecting the parotid gland and articles published in Spanish or English...
November 2, 2016: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27861675/evaluation-of-the-completeness-and-timeliness-of-malaria-reporting-in-the-brazilian-amazon-2003-2012
#10
Rui Moreira Braz, Pedro Luiz Tauil, Ana Carolina Faria E Silva Santelli, Cor Jesus Fernandes Fontes
OBJECTIVE: to evaluate the completeness and timeliness of malaria case reporting, diagnosis and treatment in the Brazilian Amazon. METHODS: this is a descriptive study using data from 23 fields of notification forms recorded on the Malaria Epidemiological Surveillance Information System (Sivep-Malaria) between 2003 and 2012. RESULTS: data completeness was good in 86.0% of fields (≥90.0% filled in); there was timely recording of 40.6% of notifications at the Municipal Health Departments (0-7 days following notification) and 75...
January 2016: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/27835023/correlated-event-by-event-fluctuations-of-flow-harmonics-in-pb-pb-collisions-at-sqrt-s_-nn-2-76%C3%A2-%C3%A2-tev
#11
J Adam, D Adamová, M M Aggarwal, G Aglieri Rinella, M Agnello, N Agrawal, Z Ahammed, S Ahmad, S U Ahn, S Aiola, A Akindinov, S N Alam, D S D Albuquerque, D Aleksandrov, B Alessandro, D Alexandre, R Alfaro Molina, A Alici, A Alkin, J R M Almaraz, J Alme, T Alt, S Altinpinar, I Altsybeev, C Alves Garcia Prado, C Andrei, A Andronic, V Anguelov, T Antičić, F Antinori, P Antonioli, L Aphecetche, H Appelshäuser, S Arcelli, R Arnaldi, O W Arnold, I C Arsene, M Arslandok, B Audurier, A Augustinus, R Averbeck, M D Azmi, A Badalà, Y W Baek, S Bagnasco, R Bailhache, R Bala, S Balasubramanian, A Baldisseri, R C Baral, A M Barbano, R Barbera, F Barile, G G Barnaföldi, L S Barnby, V Barret, P Bartalini, K Barth, J Bartke, E Bartsch, M Basile, N Bastid, S Basu, B Bathen, G Batigne, A Batista Camejo, B Batyunya, P C Batzing, I G Bearden, H Beck, C Bedda, N K Behera, I Belikov, F Bellini, H Bello Martinez, R Bellwied, R Belmont, E Belmont-Moreno, L G E Beltran, V Belyaev, G Bencedi, S Beole, I Berceanu, A Bercuci, Y Berdnikov, D Berenyi, R A Bertens, D Berzano, L Betev, A Bhasin, I R Bhat, A K Bhati, B Bhattacharjee, J Bhom, L Bianchi, N Bianchi, C Bianchin, J Bielčík, J Bielčíková, A Bilandzic, G Biro, R Biswas, S Biswas, S Bjelogrlic, J T Blair, D Blau, C Blume, F Bock, A Bogdanov, H Bøggild, L Boldizsár, M Bombara, J Book, H Borel, A Borissov, M Borri, F Bossú, E Botta, C Bourjau, P Braun-Munzinger, M Bregant, T Breitner, T A Broker, T A Browning, M Broz, E J Brucken, E Bruna, G E Bruno, D Budnikov, H Buesching, S Bufalino, P Buncic, O Busch, Z Buthelezi, J B Butt, J T Buxton, J Cabala, D Caffarri, X Cai, H Caines, L Calero Diaz, A Caliva, E Calvo Villar, P Camerini, F Carena, W Carena, F Carnesecchi, J Castillo Castellanos, A J Castro, E A R Casula, C Ceballos Sanchez, J Cepila, P Cerello, J Cerkala, B Chang, S Chapeland, M Chartier, J L Charvet, S Chattopadhyay, S Chattopadhyay, A Chauvin, V Chelnokov, M Cherney, C Cheshkov, B Cheynis, V Chibante Barroso, D D Chinellato, S Cho, P Chochula, K Choi, M Chojnacki, S Choudhury, P Christakoglou, C H Christensen, P Christiansen, T Chujo, S U Chung, C Cicalo, L Cifarelli, F Cindolo, J Cleymans, F Colamaria, D Colella, A Collu, M Colocci, G Conesa Balbastre, Z Conesa Del Valle, M E Connors, J G Contreras, T M Cormier, Y Corrales Morales, I Cortés Maldonado, P Cortese, M R Cosentino, F Costa, P Crochet, R Cruz Albino, E Cuautle, L Cunqueiro, T Dahms, A Dainese, M C Danisch, A Danu, D Das, I Das, S Das, A Dash, S Dash, S De, A De Caro, G de Cataldo, C de Conti, J de Cuveland, A De Falco, D De Gruttola, N De Marco, S De Pasquale, R D De Souza, A Deisting, A Deloff, E Dénes, C Deplano, P Dhankher, D Di Bari, A Di Mauro, P Di Nezza, B Di Ruzza, M A Diaz Corchero, T Dietel, P Dillenseger, R Divià, Ø Djuvsland, A Dobrin, D Domenicis Gimenez, B Dönigus, O Dordic, T Drozhzhova, A K Dubey, A Dubla, L Ducroux, P Dupieux, R J Ehlers, D Elia, E Endress, H Engel, E Epple, B Erazmus, I Erdemir, F Erhardt, B Espagnon, M Estienne, S Esumi, J Eum, D Evans, S Evdokimov, G Eyyubova, L Fabbietti, D Fabris, J Faivre, A Fantoni, M Fasel, L Feldkamp, A Feliciello, G Feofilov, J Ferencei, A Fernández Téllez, E G Ferreiro, A Ferretti, A Festanti, V J G Feuillard, J Figiel, M A S Figueredo, S Filchagin, D Finogeev, F M Fionda, E M Fiore, M G Fleck, M Floris, S Foertsch, P Foka, S Fokin, E Fragiacomo, A Francescon, A Francisco, U Frankenfeld, G G Fronze, U Fuchs, C Furget, A Furs, M Fusco Girard, J J Gaardhøje, M Gagliardi, A M Gago, K Gajdosova, M Gallio, C D Galvan, D R Gangadharan, P Ganoti, C Gao, C Garabatos, E Garcia-Solis, C Gargiulo, P Gasik, E F Gauger, M Germain, M Gheata, P Ghosh, S K Ghosh, P Gianotti, P Giubellino, P Giubilato, E Gladysz-Dziadus, P Glässel, D M Goméz Coral, A Gomez Ramirez, A S Gonzalez, V Gonzalez, P González-Zamora, S Gorbunov, L Görlich, S Gotovac, V Grabski, O A Grachov, L K Graczykowski, K L Graham, A Grelli, A Grigoras, C Grigoras, V Grigoriev, A Grigoryan, S Grigoryan, B Grinyov, N Grion, J M Gronefeld, J F Grosse-Oetringhaus, R Grosso, L Gruber, F Guber, R Guernane, B Guerzoni, K Gulbrandsen, T Gunji, A Gupta, R Gupta, R Haake, Ø Haaland, C Hadjidakis, M Haiduc, H Hamagaki, G Hamar, J C Hamon, J W Harris, A Harton, D Hatzifotiadou, S Hayashi, S T Heckel, E Hellbär, H Helstrup, A Herghelegiu, G Herrera Corral, B A Hess, K F Hetland, H Hillemanns, B Hippolyte, D Horak, R Hosokawa, P Hristov, C Hughes, T J Humanic, N Hussain, T Hussain, D Hutter, D S Hwang, R Ilkaev, M Inaba, E Incani, M Ippolitov, M Irfan, M Ivanov, V Ivanov, V Izucheev, B Jacak, N Jacazio, P M Jacobs, M B Jadhav, S Jadlovska, J Jadlovsky, C Jahnke, M J Jakubowska, H J Jang, M A Janik, P H S Y Jayarathna, C Jena, S Jena, R T Jimenez Bustamante, P G Jones, A Jusko, P Kalinak, A Kalweit, J Kamin, J H Kang, V Kaplin, S Kar, A Karasu Uysal, O Karavichev, T Karavicheva, L Karayan, E Karpechev, U Kebschull, R Keidel, D L D Keijdener, M Keil, M Mohisin Khan, P Khan, S A Khan, A Khanzadeev, Y Kharlov, B Kileng, D W Kim, D J Kim, D Kim, H Kim, J S Kim, J Kim, M Kim, S Kim, T Kim, S Kirsch, I Kisel, S Kiselev, A Kisiel, G Kiss, J L Klay, C Klein, J Klein, C Klein-Bösing, S Klewin, A Kluge, M L Knichel, A G Knospe, C Kobdaj, M Kofarago, T Kollegger, A Kolojvari, V Kondratiev, N Kondratyeva, E Kondratyuk, A Konevskikh, M Kopcik, M Kour, C Kouzinopoulos, O Kovalenko, V Kovalenko, M Kowalski, G Koyithatta Meethaleveedu, I Králik, A Kravčáková, M Krivda, F Krizek, E Kryshen, M Krzewicki, A M Kubera, V Kučera, C Kuhn, P G Kuijer, A Kumar, J Kumar, L Kumar, S Kumar, P Kurashvili, A Kurepin, A B Kurepin, A Kuryakin, M J Kweon, Y Kwon, S L La Pointe, P La Rocca, P Ladron de Guevara, C Lagana Fernandes, I Lakomov, R Langoy, K Lapidus, C Lara, A Lardeux, A Lattuca, E Laudi, R Lea, L Leardini, G R Lee, S Lee, F Lehas, S Lehner, R C Lemmon, V Lenti, E Leogrande, I León Monzón, H León Vargas, M Leoncino, P Lévai, S Li, X Li, J Lien, R Lietava, S Lindal, V Lindenstruth, C Lippmann, M A Lisa, H M Ljunggren, D F Lodato, P I Loenne, V Loginov, C Loizides, X Lopez, E López Torres, A Lowe, P Luettig, M Lunardon, G Luparello, T H Lutz, A Maevskaya, M Mager, S Mahajan, S M Mahmood, A Maire, R D Majka, M Malaev, I Maldonado Cervantes, L Malinina, D Mal'Kevich, P Malzacher, A Mamonov, V Manko, F Manso, V Manzari, M Marchisone, J Mareš, G V Margagliotti, A Margotti, J Margutti, A Marín, C Markert, M Marquard, N A Martin, J Martin Blanco, P Martinengo, M I Martínez, G Martínez García, M Martinez Pedreira, A Mas, S Masciocchi, M Masera, A Masoni, A Mastroserio, A Matyja, C Mayer, J Mazer, M A Mazzoni, D Mcdonald, F Meddi, Y Melikyan, A Menchaca-Rocha, E Meninno, J Mercado Pérez, M Meres, Y Miake, M M Mieskolainen, K Mikhaylov, L Milano, J Milosevic, A Mischke, A N Mishra, D Miśkowiec, J Mitra, C M Mitu, N Mohammadi, B Mohanty, L Molnar, L Montaño Zetina, E Montes, D A Moreira De Godoy, L A P Moreno, S Moretto, A Morreale, A Morsch, V Muccifora, E Mudnic, D Mühlheim, S Muhuri, M Mukherjee, J D Mulligan, M G Munhoz, K Münning, R H Munzer, H Murakami, S Murray, L Musa, J Musinsky, B Naik, R Nair, B K Nandi, R Nania, E Nappi, M U Naru, H Natal da Luz, C Nattrass, S R Navarro, K Nayak, R Nayak, T K Nayak, S Nazarenko, A Nedosekin, L Nellen, F Ng, M Nicassio, M Niculescu, J Niedziela, B S Nielsen, S Nikolaev, S Nikulin, V Nikulin, F Noferini, P Nomokonov, G Nooren, J C C Noris, J Norman, A Nyanin, J Nystrand, H Oeschler, S Oh, S K Oh, A Ohlson, A Okatan, T Okubo, J Oleniacz, A C Oliveira Da Silva, M H Oliver, J Onderwaater, C Oppedisano, R Orava, M Oravec, A Ortiz Velasquez, A Oskarsson, J Otwinowski, K Oyama, M Ozdemir, Y Pachmayer, D Pagano, P Pagano, G Paić, S K Pal, J Pan, A K Pandey, V Papikyan, G S Pappalardo, P Pareek, W J Park, S Parmar, A Passfeld, V Paticchio, R N Patra, B Paul, H Pei, T Peitzmann, X Peng, H Pereira Da Costa, D Peresunko, E Perez Lezama, V Peskov, Y Pestov, V Petráček, V Petrov, M Petrovici, C Petta, S Piano, M Pikna, P Pillot, L O D L Pimentel, O Pinazza, L Pinsky, D B Piyarathna, M Płoskoń, M Planinic, J Pluta, S Pochybova, P L M Podesta-Lerma, M G Poghosyan, B Polichtchouk, N Poljak, W Poonsawat, A Pop, H Poppenborg, S Porteboeuf-Houssais, J Porter, J Pospisil, S K Prasad, R Preghenella, F Prino, C A Pruneau, I Pshenichnov, M Puccio, G Puddu, P Pujahari, V Punin, J Putschke, H Qvigstad, A Rachevski, S Raha, S Rajput, J Rak, A Rakotozafindrabe, L Ramello, F Rami, R Raniwala, S Raniwala, S S Räsänen, B T Rascanu, D Rathee, K F Read, K Redlich, R J Reed, A Rehman, P Reichelt, F Reidt, X Ren, R Renfordt, A R Reolon, A Reshetin, K Reygers, V Riabov, R A Ricci, T Richert, M Richter, P Riedler, W Riegler, F Riggi, C Ristea, E Rocco, M Rodríguez Cahuantzi, A Rodriguez Manso, K Røed, E Rogochaya, D Rohr, D Röhrich, F Ronchetti, L Ronflette, P Rosnet, A Rossi, F Roukoutakis, A Roy, C Roy, P Roy, A J Rubio Montero, R Rui, R Russo, E Ryabinkin, Y Ryabov, A Rybicki, S Saarinen, S Sadhu, S Sadovsky, K Šafařík, B Sahlmuller, P Sahoo, R Sahoo, S Sahoo, P K Sahu, J Saini, S Sakai, M A Saleh, J Salzwedel, S Sambyal, V Samsonov, L Šándor, A Sandoval, M Sano, D Sarkar, N Sarkar, P Sarma, E Scapparone, F Scarlassara, C Schiaua, R Schicker, C Schmidt, H R Schmidt, M Schmidt, S Schuchmann, J Schukraft, M Schulc, Y Schutz, K Schwarz, K Schweda, G Scioli, E Scomparin, R Scott, M Šefčík, J E Seger, Y Sekiguchi, D Sekihata, I Selyuzhenkov, K Senosi, S Senyukov, E Serradilla, A Sevcenco, A Shabanov, A Shabetai, O Shadura, R Shahoyan, M I Shahzad, A Shangaraev, A Sharma, M Sharma, M Sharma, N Sharma, A I Sheikh, K Shigaki, Q Shou, K Shtejer, Y Sibiriak, S Siddhanta, K M Sielewicz, T Siemiarczuk, D Silvermyr, C Silvestre, G Simatovic, G Simonetti, R Singaraju, R Singh, V Singhal, T Sinha, B Sitar, M Sitta, T B Skaali, M Slupecki, N Smirnov, R J M Snellings, T W Snellman, J Song, M Song, Z Song, F Soramel, S Sorensen, F Sozzi, M Spacek, E Spiriti, I Sputowska, M Spyropoulou-Stassinaki, J Stachel, I Stan, P Stankus, E Stenlund, G Steyn, J H Stiller, D Stocco, P Strmen, A A P Suaide, T Sugitate, C Suire, M Suleymanov, M Suljic, R Sultanov, M Šumbera, S Sumowidagdo, A Szabo, I Szarka, A Szczepankiewicz, M Szymanski, U Tabassam, J Takahashi, G J Tambave, N Tanaka, M Tarhini, M Tariq, M G Tarzila, A Tauro, G Tejeda Muñoz, A Telesca, K Terasaki, C Terrevoli, B Teyssier, J Thäder, D Thakur, D Thomas, R Tieulent, A Tikhonov, A R Timmins, A Toia, S Trogolo, G Trombetta, V Trubnikov, W H Trzaska, T Tsuji, A Tumkin, R Turrisi, T S Tveter, K Ullaland, A Uras, G L Usai, A Utrobicic, M Vala, L Valencia Palomo, S Vallero, J Van Der Maarel, J W Van Hoorne, M van Leeuwen, T Vanat, P Vande Vyvre, D Varga, A Vargas, M Vargyas, R Varma, M Vasileiou, A Vasiliev, A Vauthier, O Vázquez Doce, V Vechernin, A M Veen, M Veldhoen, A Velure, E Vercellin, S Vergara Limón, R Vernet, M Verweij, L Vickovic, J Viinikainen, Z Vilakazi, O Villalobos Baillie, A Villatoro Tello, A Vinogradov, L Vinogradov, Y Vinogradov, T Virgili, V Vislavicius, Y P Viyogi, A Vodopyanov, M A Völkl, K Voloshin, S A Voloshin, G Volpe, B von Haller, I Vorobyev, D Vranic, J Vrláková, B Vulpescu, B Wagner, J Wagner, H Wang, M Wang, D Watanabe, Y Watanabe, M Weber, S G Weber, D F Weiser, J P Wessels, U Westerhoff, A M Whitehead, J Wiechula, J Wikne, G Wilk, J Wilkinson, M C S Williams, B Windelband, M Winn, P Yang, S Yano, Z Yasin, Z Yin, H Yokoyama, I-K Yoo, J H Yoon, V Yurchenko, A Zaborowska, V Zaccolo, A Zaman, C Zampolli, H J C Zanoli, S Zaporozhets, N Zardoshti, A Zarochentsev, P Závada, N Zaviyalov, H Zbroszczyk, I S Zgura, M Zhalov, H Zhang, X Zhang, Y Zhang, C Zhang, Z Zhang, C Zhao, N Zhigareva, D Zhou, Y Zhou, Z Zhou, H Zhu, J Zhu, A Zichichi, A Zimmermann, M B Zimmermann, G Zinovjev, M Zyzak
We report the measurements of correlations between event-by-event fluctuations of amplitudes of anisotropic flow harmonics in nucleus-nucleus collisions, obtained for the first time using a new analysis method based on multiparticle cumulants in mixed harmonics. This novel method is robust against systematic biases originating from nonflow effects and by construction any dependence on symmetry planes is eliminated. We demonstrate that correlations of flow harmonics exhibit a better sensitivity to medium properties than the individual flow harmonics...
October 28, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27829983/melatoninergic-system-in-parkinson-s-disease-from-neuroprotection-to-the-management-of-motor-and-nonmotor-symptoms
#12
REVIEW
Josiel Mileno Mack, Marissa Giovanna Schamne, Tuane Bazanella Sampaio, Renata Aparecida Nedel Pértile, Pedro Augusto Carlos Magno Fernandes, Regina P Markus, Rui Daniel Prediger
Melatonin is synthesized by several tissues besides the pineal gland, and beyond its regulatory effects in light-dark cycle, melatonin is a hormone with neuroprotective, anti-inflammatory, and antioxidant properties. Melatonin acts as a free-radical scavenger, reducing reactive species and improving mitochondrial homeostasis. Melatonin also regulates the expression of neurotrophins that are involved in the survival of dopaminergic neurons and reduces α-synuclein aggregation, thus protecting the dopaminergic system against damage...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27759781/brazilian-consensus-for-multimodal-treatment-of-colorectal-liver-metastases-module-3-controversies-and-unresectable-metastases
#13
Orlando Jorge Martins Torres, Márcio Carmona Marques, Fabio Nasser Santos, Igor Correia de Farias, Anelisa Kruschewsky Coutinho, Cássio Virgílio Cavalcante de Oliveira, Antonio Nocchi Kalil, Celso Abdon Lopes de Mello, Jaime Arthur Pirola Kruger, Gustavo Dos Santos Fernandes, Claudemiro Quireze, André M Murad, Milton José de Barros E Silva, Charles Edouard Zurstrassen, Helano Carioca Freitas, Marcelo Rocha Cruz, Rui Weschenfelder, Marcelo Moura Linhares, Leonaldson Dos Santos Castro, Charles Vollmer, Elijah Dixon, Héber Salvador de Castro Ribeiro, Felipe José Fernandez Coimbra
In the last module of this consensus, controversial topics were discussed. Management of the disease after progression during first line chemotherapy was the first discussion. Next, the benefits of liver resection in the presence of extra-hepatic disease were debated, as soon as, the best sequence of treatment. Conversion chemotherapy in the presence of unresectable liver disease was also discussed in this module. Lastly, the approach to the unresectable disease was also discussed, focusing in the best chemotherapy regimens and hole of chemo-embolization...
July 2016: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/27751655/fully-automatic-segmentation-of-femurs-with-medullary-canal-definition-in-high-and-in-low-resolution-ct-scans
#14
Diogo F Almeida, Rui B Ruben, João Folgado, Paulo R Fernandes, Emmanuel Audenaert, Benedict Verhegghe, Matthieu De Beule
Femur segmentation can be an important tool in orthopedic surgical planning. However, in order to overcome the need of an experienced user with extensive knowledge on the techniques, segmentation should be fully automatic. In this paper a new fully automatic femur segmentation method for CT images is presented. This method is also able to define automatically the medullary canal and performs well even in low resolution CT scans. Fully automatic femoral segmentation was performed adapting a template mesh of the femoral volume to medical images...
October 14, 2016: Medical Engineering & Physics
https://www.readbyqxmd.com/read/27741520/prevalence-of-brca1-brca2-mutations-in-a-brazilian-population-sample-at-risk-for-hereditary-breast-cancer-and-characterization-of-its-genetic-ancestry
#15
Gabriela C Fernandes, Rodrigo Ad Michelli, Henrique Cr Galvão, André E Paula, Rui Pereira, Carlos E Andrade, Paula S Felicio, Cristiano P Souza, Deise Rp Mendes, Sahlua Volc, Gustavo N Berardinelli, Rebeca S Grasel, Cristina S Sabato, Danilo V Viana, Edmundo C Mauad, Cristovam Scapulatempo-Neto, Banu Arun, Rui M Reis, Edenir I Palmero
BACKGROUND: There are very few data about the mutational profile of families at-risk for hereditary breast and ovarian cancer (HBOC) from Latin America (LA) and especially from Brazil, the largest and most populated country in LA. RESULTS: Of the 349 probands analyzed, 21.5% were BRCA1/BRCA2 mutated, 65.3% at BRCA1 and 34.7% at BRCA2 gene. The mutation c.5266dupC (former 5382insC) was the most frequent alteration, representing 36.7% of the BRCA1 mutations and 24...
October 12, 2016: Oncotarget
https://www.readbyqxmd.com/read/27689436/quantification-of-small-extracellular-vesicles-by-size-exclusion-chromatography-with-fluorescence-detection
#16
Rui Xu, Austin Fitts, Xiangtang Li, Joseph Fernandes, Radhika Pochampally, Jinghe Mao, Yi-Ming Liu
Chemical analysis of small extracellular vesicles (sEVs) circulating in body fluids holds potentials in noninvasive diagnosis of diseases and evaluation of therapeutic treatments. However, quantification of sEVs remains a challenge due to lacking of cost-effective analytical protocols. Herein we report a facile method based on size exclusion chromatography with fluorescence detection (SEC-FD) for sEVs quantification. After removal of cells and cell debris, a 0.50 mL sample (e.g., cell culture medium) is incubated with CM-Dil dye to fluorescently label sEVs...
November 1, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27566985/oral-head-and-neck-oncologic-and-reconstructive-surgery-fellowship-training-programs-transformation-of-the-specialty-from-2005-to-2015-report-from-the-aaoms-committee-on-maxillofacial-oncology-and-reconstructive-surgery
#17
Deepak Kademani, Brian Woo, Brent Ward, Rui Fernandes, Eric Carlson, Joseph Helman, Ghali E Ghali, Paul Lambert
Oral and Maxillofacial Surgeons have increasing opportunities to train in head and neck oncologic and reconstructive surgery. The development of a fellowship training programs within our speciality has had a transformative effect on the speciality. This survey by the commitee on Maxillofacial Oncology and Reconstructive is aimed to evaluate the impact of fellowship training on the careers of the fellows and speciality from 2005-2015.
November 2016: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27556311/endovascular-treatment-of-internal-iliac-artery-aneurysms-single-center-experience
#18
Rui Manuel Machado, Duarte Nuno Cunha Rego, Pedro Nuno Ferreira Pinto de Oliveira, Rui Manuel Gonçalves Fernandes de Almeida
OBJECTIVE: Internal iliac artery aneurysms (IIAA) are rare, representing only 0.3% of aortoiliac aneurysms. Its treatment with open surgery is complex and associated with high morbidity and mortality, which led to increasing application of endovascular solutions. In this study, we aimed to evaluate outcomes of endovascular aneurysm repair (EVAR) of IIAA in one institution. METHODS: We retrospectively reviewed all cases of IIAA treated with endovascular techniques between 2003 and 2014...
April 2016: Brazilian Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/27554018/reinforcement-of-poly-l-lactic-acid-electrospun-membranes-with-strontium-borosilicate-bioactive-glasses-for-bone-tissue-engineering
#19
João S Fernandes, Piergiorgio Gentile, Margarida Martins, Nuno M Neves, Cheryl Miller, Aileen Crawford, Ricardo A Pires, Paul Hatton, Rui L Reis
UNLABELLED: Herein, for the first time, we combined poly-l-lactic acid (PLLA) with a strontium borosilicate bioactive glass (BBG-Sr) using electrospinning to fabricate a composite bioactive PLLA membrane loaded with 10% (w/w) of BBG-Sr glass particles (PLLA-BBG-Sr). The composites were characterised by scanning electron microscopy (SEM) and microcomputer tomography (μ-CT), and the results showed that we successfully fabricated smooth and uniform fibres (1-3μm in width) with a homogeneous distribution of BBG-Sr microparticles (<45μm)...
October 15, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27528106/clinical-pathway-implementation-improves-efficiency-of-care-in-a-maxillofacial-head-and-neck-surgery-unit
#20
Jacob G Yetzer, Phillip Pirgousis, Zhuo Li, Rui Fernandes
PURPOSE: Clinical pathways have become an important and simple method of improving patient outcomes and decreasing health care resource usage. The purpose of this study was to evaluate early outcomes associated with the implementation of a clinical pathway in a maxillofacial head and neck surgery unit. MATERIALS AND METHODS: This investigation is a retrospective cohort study of patients who underwent microvascular reconstruction of the head and neck from January 1, 2014 through December 31, 2014...
January 2017: Journal of Oral and Maxillofacial Surgery
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